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Conserved domains on  [gi|1409931462|ref|NP_079827|]
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NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 isoform 1 [Mus musculus]

Protein Classification

complex I NDUFA12 subunit family protein( domain architecture ID 10523838)

complex I NDUFA12 subunit family protein similar to NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 (NDUFA12), an accessory subunit that is not involved in catalysis of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NDUFA12 pfam05071
NADH ubiquinone oxidoreductase subunit NDUFA12; This family contains the 17.2 kD subunit of ...
 37-137 3.23e-41

NADH ubiquinone oxidoreductase subunit NDUFA12; This family contains the 17.2 kD subunit of complex I (NDUFA12) and its homologs. The family also contains a second related eukaryotic protein of unknown function,.


:

Pssm-ID: 461542  Cd Length: 96  Bit Score: 132.72  E-value: 3.23e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931462  37 TLVGEDKYGNKYYEDNK-QFFGRHRWVIYTTemngkntfWDVDGSMVPPEWHRWLHCMTDDPPTTNPPTARKFIWTNHKF 115
Cdd:pfam05071   1 TLVGEDEFGNKYYENKDeELPGRRRWVIYND--------GDYDASQVPPEWHGWLHYITDDPPTEDPILQPRPWEKPHQP 72

                          90       100
                  ....*....|....*....|....
gi 1409931462 116 NVSATPEQY--VPYSTTRKKIHEW 137
Cdd:pfam05071  73 NLTGTPRAYrgKPYSTTKPKYEAW 96
 
Name Accession Description Interval E-value
NDUFA12 pfam05071
NADH ubiquinone oxidoreductase subunit NDUFA12; This family contains the 17.2 kD subunit of ...
 37-137 3.23e-41

NADH ubiquinone oxidoreductase subunit NDUFA12; This family contains the 17.2 kD subunit of complex I (NDUFA12) and its homologs. The family also contains a second related eukaryotic protein of unknown function,.


Pssm-ID: 461542  Cd Length: 96  Bit Score: 132.72  E-value: 3.23e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931462  37 TLVGEDKYGNKYYEDNK-QFFGRHRWVIYTTemngkntfWDVDGSMVPPEWHRWLHCMTDDPPTTNPPTARKFIWTNHKF 115
Cdd:pfam05071   1 TLVGEDEFGNKYYENKDeELPGRRRWVIYND--------GDYDASQVPPEWHGWLHYITDDPPTEDPILQPRPWEKPHQP 72

                          90       100
                  ....*....|....*....|....
gi 1409931462 116 NVSATPEQY--VPYSTTRKKIHEW 137
Cdd:pfam05071  73 NLTGTPRAYrgKPYSTTKPKYEAW 96
NDUFA12 COG3761
NADH:ubiquinone oxidoreductase NDUFA12 subunit (Leigh syndrome) [Energy production and ...
 34-126 1.17e-22

NADH:ubiquinone oxidoreductase NDUFA12 subunit (Leigh syndrome) [Energy production and conversion]; NADH:ubiquinone oxidoreductase NDUFA12 subunit (Leigh syndrome) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 442975 [Multi-domain]  Cd Length: 132  Bit Score: 86.45  E-value: 1.17e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931462  34 RIGTLVGEDKYGNKYYE--DNKQFFGRHRWVIYttemNGKNtfwdvDGSMVPPEWHRWLHCMTDDPPTTNPPTARkfIW- 110
Cdd:COG3761    24 RKGEKVGEDEFGNRYYRtkDGKALGRERRWVIY----NGYA-----EASRVPPEWHGWLHHTTDEPPTEEPYPPR--PWe 92

                          90
                  ....*....|....*.
gi 1409931462 111 TNHKFNVSATPEQYVP 126
Cdd:COG3761    93 KPHQPNLTGTPLAYRP 108
PRK08183 PRK08183
NADH:ubiquinone oxidoreductase subunit NDUFA12;
34-126 8.15e-22

NADH:ubiquinone oxidoreductase subunit NDUFA12;


Pssm-ID: 236176 [Multi-domain]  Cd Length: 133  Bit Score: 84.27  E-value: 8.15e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931462  34 RIGTLVGEDKYGNKYY--EDNKQFFGR-HRWVIYttemNGKNtfwdvDGSMVPPEWHRWLHCMTDDPPTTNPPTARkfIW 110
Cdd:PRK08183   24 RKGERVGEDEFGNVYYrtKGGKPSDGReRRWVIY----NGYA-----EASRIPPEWHGWLHHTVDVPPTKEPYPPR--EW 92

                          90
                  ....*....|....*..
gi 1409931462 111 -TNHKFNVSATPEQYVP 126
Cdd:PRK08183   93 eKPHQPNLTGTPLAYRP 109
 
Name Accession Description Interval E-value
NDUFA12 pfam05071
NADH ubiquinone oxidoreductase subunit NDUFA12; This family contains the 17.2 kD subunit of ...
 37-137 3.23e-41

NADH ubiquinone oxidoreductase subunit NDUFA12; This family contains the 17.2 kD subunit of complex I (NDUFA12) and its homologs. The family also contains a second related eukaryotic protein of unknown function,.


Pssm-ID: 461542  Cd Length: 96  Bit Score: 132.72  E-value: 3.23e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931462  37 TLVGEDKYGNKYYEDNK-QFFGRHRWVIYTTemngkntfWDVDGSMVPPEWHRWLHCMTDDPPTTNPPTARKFIWTNHKF 115
Cdd:pfam05071   1 TLVGEDEFGNKYYENKDeELPGRRRWVIYND--------GDYDASQVPPEWHGWLHYITDDPPTEDPILQPRPWEKPHQP 72

                          90       100
                  ....*....|....*....|....
gi 1409931462 116 NVSATPEQY--VPYSTTRKKIHEW 137
Cdd:pfam05071  73 NLTGTPRAYrgKPYSTTKPKYEAW 96
NDUFA12 COG3761
NADH:ubiquinone oxidoreductase NDUFA12 subunit (Leigh syndrome) [Energy production and ...
 34-126 1.17e-22

NADH:ubiquinone oxidoreductase NDUFA12 subunit (Leigh syndrome) [Energy production and conversion]; NADH:ubiquinone oxidoreductase NDUFA12 subunit (Leigh syndrome) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 442975 [Multi-domain]  Cd Length: 132  Bit Score: 86.45  E-value: 1.17e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931462  34 RIGTLVGEDKYGNKYYE--DNKQFFGRHRWVIYttemNGKNtfwdvDGSMVPPEWHRWLHCMTDDPPTTNPPTARkfIW- 110
Cdd:COG3761    24 RKGEKVGEDEFGNRYYRtkDGKALGRERRWVIY----NGYA-----EASRVPPEWHGWLHHTTDEPPTEEPYPPR--PWe 92

                          90
                  ....*....|....*.
gi 1409931462 111 TNHKFNVSATPEQYVP 126
Cdd:COG3761    93 KPHQPNLTGTPLAYRP 108
PRK08183 PRK08183
NADH:ubiquinone oxidoreductase subunit NDUFA12;
34-126 8.15e-22

NADH:ubiquinone oxidoreductase subunit NDUFA12;


Pssm-ID: 236176 [Multi-domain]  Cd Length: 133  Bit Score: 84.27  E-value: 8.15e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931462  34 RIGTLVGEDKYGNKYY--EDNKQFFGR-HRWVIYttemNGKNtfwdvDGSMVPPEWHRWLHCMTDDPPTTNPPTARkfIW 110
Cdd:PRK08183   24 RKGERVGEDEFGNVYYrtKGGKPSDGReRRWVIY----NGYA-----EASRIPPEWHGWLHHTVDVPPTKEPYPPR--EW 92

                          90
                  ....*....|....*..
gi 1409931462 111 -TNHKFNVSATPEQYVP 126
Cdd:PRK08183   93 eKPHQPNLTGTPLAYRP 109
PLN03095 PLN03095
NADH:ubiquinone oxidoreductase 18 kDa subunit; Provisional
 34-108 3.75e-17

NADH:ubiquinone oxidoreductase 18 kDa subunit; Provisional


Pssm-ID: 215571  Cd Length: 115  Bit Score: 71.84  E-value: 3.75e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1409931462  34 RIGTLVGEDKYGNKYYEDNKQFFGRHRWVIYttemngKNTFwDVDGSMVPPEWHRWLHCMTDDPPTTNPPTARKF 108
Cdd:PLN03095    8 RAGRLVGEDEFGNKYYENPSYQSGRHRWVEY------ADKD-DYNASNIPPEWHGWLHYVNDEPGELEDRTAPRY 75
PLN02732 PLN02732
Probable NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit
 37-128 4.95e-15

Probable NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit


Pssm-ID: 215389  Cd Length: 159  Bit Score: 67.65  E-value: 4.95e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931462  37 TLVGEDKYGNKYYED-NKQFFGRHRWVIYTTemngKNTFwdvDGSMVPPEWHRWLHCMTDDPPTTNPPTARKFIWTNHKF 115
Cdd:PLN02732   50 TLVGVDKFGNKYYQKlGDTQYGRHRWVEYAE----KSRY---NASQVPAEWHGWLHFITDHTGDELLMLKPKRYGLEHKE 122

                          90
                  ....*....|...
gi 1409931462 116 NVSATPEQYVPYS 128
Cdd:PLN02732  123 NFSGEGEEYIYHS 135
PRK06630 PRK06630
hypothetical protein; Provisional
 39-98 8.27e-06

hypothetical protein; Provisional


Pssm-ID: 168631  Cd Length: 99  Bit Score: 41.88  E-value: 8.27e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1409931462  39 VGEDKYGNKYYED-NKQFFGR-HRWVIYttemngKNTfwdVDGSMVPPEWHRWLHCMTDDPP 98
Cdd:PRK06630   16 VGEDEFLNQYYESrNIDYLGRpRRFVIY------KNV---NEPTKIPPSWHAWLHHLVNEIP 68
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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