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Conserved domains on  [gi|13435364|ref|NP_077740|]
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desmocollin-2 isoform Dsc2a preproprotein [Homo sapiens]

Protein Classification

cadherin repeat domain-containing protein( domain architecture ID 11279595)

cadherin repeat domain-containing protein similar to cadherins, which are calcium-dependent cell adhesion proteins that preferentially interact with themselves in connecting cells

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_pro smart01055
Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent ...
 31-111 1.01e-29

Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions.


:

Pssm-ID: 214999  Cd Length: 87  Bit Score: 112.76  E-value: 1.01e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13435364     31 ACKNVTLHVPSKLDAEKLVGRVNLKECFTAANL-IHSSDPDFQILEDGSVYTTNTILLSSEKRSFTILLSNTENQEKKKI 109
Cdd:smart01055   6 SEEKYTFHVPSHLEAGQPLGRVNFEECLGSARLqFESSDPDFRVLEDGTVYATRPVSLSSEKKSFTVLAWDSQGQEKKEI 85


                   ..
gi 13435364    110 FV 111
Cdd:smart01055  86 KV 87
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 247-351 1.36e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 104.32  E-value: 1.36e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13435364 247 TYTFTIFENCRVGTTVGQVCATDKDEPdtMHTRLKYSIIGQVPPSptLFSMHPTTGVITTTSSqLDRELIDKYQLKIKVQ 326
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSG--ENGEVTYSIVSGNEDG--LFSIDPSTGEITTAKP-LDREEQSSYTLTVTAT 75

                        90       100
                ....*....|....*....|....*
gi 13435364 327 DMDGQyfGLQTTSTCIINIDDVNDH 351
Cdd:cd11304  76 DGGGP--PLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
360-463 5.56e-18

Cadherin domain;


:

Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 79.65  E-value: 5.56e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13435364   360 YVTSVEENT-VDVEILRVTVEDKDLvnTANWRANYTILKGNENGNFKIVTDAktneGVLCVVKPLNYEEKQQMILQIGVV 438
Cdd:pfam00028   1 YSASVPENApVGTEVLTVTATDPDL--GPNGRIFYSILGGGPGGNFRIDPDT----GDISTTKPLDRESIGEYELTVEAT 74

                          90       100
                  ....*....|....*....|....*
gi 13435364   439 NEAPFSREasprsamSTATVTVNVE 463
Cdd:pfam00028  75 DSGGPPLS-------STATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 477-573 1.41e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 75.81  E-value: 1.41e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13435364 477 TVRMKENAEVGTTSNGYKAYDPETRSSSGIRYKKLT-DPTGWVTIDENTGSIKVFRSLDREaetiKNGIYNITVLASDQG 555
Cdd:cd11304   3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSgNEDGLFSIDPSTGEITTAKPLDRE----EQSSYTLTVTATDGG 78

                        90       100
                ....*....|....*....|
gi 13435364 556 G--RTCTGTLGIILQDVNDN 573
Cdd:cd11304  79 GppLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
140-234 5.92e-15

Cadherin domain;


:

Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 71.18  E-value: 5.92e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13435364   140 IPCSMLENSL-GPFPLFLQQVQSDTAQNYTIYYSIRGPGVDqeprNLFYVERDTGNLYCTRPVDREQYESFEIIAFATTP 218
Cdd:pfam00028   1 YSASVPENAPvGTEVLTVTATDPDLGPNGRIFYSILGGGPG----GNFRIDPDTGDISTTKPLDRESIGEYELTVEATDS 76

                          90
                  ....*....|....*.
gi 13435364   219 DGYTPELPLPLIIKIE 234
Cdd:pfam00028  77 GGPPLSSTATVTITVL 92
CADH_Y-type_LIR super family cl03079
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 852-896 3.60e-08

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


The actual alignment was detected with superfamily member pfam01049:

Pssm-ID: 460041  Cd Length: 60  Bit Score: 50.61  E-value: 3.60e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 13435364   852 DYVLTYNYEGRGSVAG---SVGCCSERQEEDgLEFLDNLEPKFRTLAE 896
Cdd:pfam01049  11 DSLQTYAYEGDGSSAGslsSLESSTSDSDQD-YDYLSDWGPRFKKLAE 57
 
Name Accession Description Interval E-value
Cadherin_pro smart01055
Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent ...
 31-111 1.01e-29

Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions.


Pssm-ID: 214999  Cd Length: 87  Bit Score: 112.76  E-value: 1.01e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13435364     31 ACKNVTLHVPSKLDAEKLVGRVNLKECFTAANL-IHSSDPDFQILEDGSVYTTNTILLSSEKRSFTILLSNTENQEKKKI 109
Cdd:smart01055   6 SEEKYTFHVPSHLEAGQPLGRVNFEECLGSARLqFESSDPDFRVLEDGTVYATRPVSLSSEKKSFTVLAWDSQGQEKKEI 85


                   ..
gi 13435364    110 FV 111
Cdd:smart01055  86 KV 87
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 247-351 1.36e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 104.32  E-value: 1.36e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13435364 247 TYTFTIFENCRVGTTVGQVCATDKDEPdtMHTRLKYSIIGQVPPSptLFSMHPTTGVITTTSSqLDRELIDKYQLKIKVQ 326
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSG--ENGEVTYSIVSGNEDG--LFSIDPSTGEITTAKP-LDREEQSSYTLTVTAT 75

                        90       100
                ....*....|....*....|....*
gi 13435364 327 DMDGQyfGLQTTSTCIINIDDVNDH 351
Cdd:cd11304  76 DGGGP--PLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
248-345 8.20e-21

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 87.74  E-value: 8.20e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13435364   248 YTFTIFENCRVGTTVGQVCATDKDEPDtmHTRLKYSIIGQvpPSPTLFSMHPTTGVITTTsSQLDRELIDKYQLKIKVQD 327
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGP--NGRIFYSILGG--GPGGNFRIDPDTGDISTT-KPLDRESIGEYELTVEATD 75

                          90
                  ....*....|....*...
gi 13435364   328 MDGQyfGLQTTSTCIINI 345
Cdd:pfam00028  76 SGGP--PLSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
360-463 5.56e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 79.65  E-value: 5.56e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13435364   360 YVTSVEENT-VDVEILRVTVEDKDLvnTANWRANYTILKGNENGNFKIVTDAktneGVLCVVKPLNYEEKQQMILQIGVV 438
Cdd:pfam00028   1 YSASVPENApVGTEVLTVTATDPDL--GPNGRIFYSILGGGPGGNFRIDPDT----GDISTTKPLDRESIGEYELTVEAT 74

                          90       100
                  ....*....|....*....|....*
gi 13435364   439 NEAPFSREasprsamSTATVTVNVE 463
Cdd:pfam00028  75 DSGGPPLS-------STATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 267-353 6.59e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 78.93  E-value: 6.59e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13435364    267 ATDKDEPDtmHTRLKYSIIGQVPPSPtlFSMHPTTGVITTTSsQLDRELIDKYQLKIKVQDMDGQyfGLQTTSTCIINID 346
Cdd:smart00112   2 ATDADSGE--NGKVTYSILSGNDDGL--FSIDPETGEITTTK-PLDREEQPEYTLTVEATDGGGP--PLSSTATVTITVL 74


                   ....*..
gi 13435364    347 DVNDHLP 353
Cdd:smart00112  75 DVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 359-467 1.37e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 78.89  E-value: 1.37e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13435364 359 SYVTSVEENT-VDVEILRVTVEDKDLvnTANWRANYTILKGNENGNFKIvtDAKTneGVLCVVKPLNYEEKQQMILQIGV 437
Cdd:cd11304   1 SYEVSVPENApPGTVVLTVSATDPDS--GENGEVTYSIVSGNEDGLFSI--DPST--GEITTAKPLDREEQSSYTLTVTA 74

                        90       100       110
                ....*....|....*....|....*....|
gi 13435364 438 VNEAPFSREasprsamSTATVTVNVEDQDE 467
Cdd:cd11304  75 TDGGGPPLS-------STATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 477-573 1.41e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 75.81  E-value: 1.41e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13435364 477 TVRMKENAEVGTTSNGYKAYDPETRSSSGIRYKKLT-DPTGWVTIDENTGSIKVFRSLDREaetiKNGIYNITVLASDQG 555
Cdd:cd11304   3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSgNEDGLFSIDPSTGEITTAKPLDRE----EQSSYTLTVTATDGG 78

                        90       100
                ....*....|....*....|
gi 13435364 556 G--RTCTGTLGIILQDVNDN 573
Cdd:cd11304  79 GppLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
476-568 3.99e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 74.26  E-value: 3.99e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13435364   476 QTVRMKENAEVGTTSNGYKAYDPETRSSSGIRYKKL-TDPTGWVTIDENTGSIKVFRSLDREAetikNGIYNITVLASDQ 554
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILgGGPGGNFRIDPDTGDISTTKPLDRES----IGEYELTVEATDS 76

                          90
                  ....*....|....*.
gi 13435364   555 G--GRTCTGTLGIILQ 568
Cdd:pfam00028  77 GgpPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 494-575 2.05e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 72.00  E-value: 2.05e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13435364    494 KAYDPETRSSSGIRYKKLT-DPTGWVTIDENTGSIKVFRSLDREaetiKNGIYNITVLASDQGG--RTCTGTLGIILQDV 570
Cdd:smart00112   1 SATDADSGENGKVTYSILSgNDDGLFSIDPETGEITTTKPLDRE----EQPEYTLTVEATDGGGppLSSTATVTITVLDV 76


                   ....*
gi 13435364    571 NDNSP 575
Cdd:smart00112  77 NDNAP 81
Cadherin pfam00028
Cadherin domain;
140-234 5.92e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 71.18  E-value: 5.92e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13435364   140 IPCSMLENSL-GPFPLFLQQVQSDTAQNYTIYYSIRGPGVDqeprNLFYVERDTGNLYCTRPVDREQYESFEIIAFATTP 218
Cdd:pfam00028   1 YSASVPENAPvGTEVLTVTATDPDLGPNGRIFYSILGGGPG----GNFRIDPDTGDISTTKPLDRESIGEYELTVEATDS 76

                          90
                  ....*....|....*.
gi 13435364   219 DGYTPELPLPLIIKIE 234
Cdd:pfam00028  77 GGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 161-241 7.69e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 64.68  E-value: 7.69e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13435364    161 SDTAQNYTIYYSIrgpgVDQEPRNLFYVERDTGNLYCTRPVDREQYESFEIIAFATTPDGYTPELPLPLIIKIEDENDNY 240
Cdd:smart00112   5 ADSGENGKVTYSI----LSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                   .
gi 13435364    241 P 241
Cdd:smart00112  81 P 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 162-239 2.02e-12

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 63.87  E-value: 2.02e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13435364 162 DTAQNYTIYYSIrgpgVDQEPRNLFYVERDTGNLYCTRPVDREQYESFEIIAFATtpDGYTPEL--PLPLIIKIEDENDN 239
Cdd:cd11304  25 DSGENGEVTYSI----VSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTAT--DGGGPPLssTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 377-474 9.62e-12

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 61.60  E-value: 9.62e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13435364    377 TVEDKDLvnTANWRANYTILKGNENGNFKIvtDAKTneGVLCVVKPLNYEEKQQMILQIGVVNEAPFSREasprsamSTA 456
Cdd:smart00112   1 SATDADS--GENGKVTYSILSGNDDGLFSI--DPET--GEITTTKPLDREEQPEYTLTVEATDGGGPPLS-------STA 67

                           90
                   ....*....|....*...
gi 13435364    457 TVTVNVEDQDEgpecNPP 474
Cdd:smart00112  68 TVTITVLDVND----NAP 81
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 852-896 3.60e-08

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


Pssm-ID: 460041  Cd Length: 60  Bit Score: 50.61  E-value: 3.60e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 13435364   852 DYVLTYNYEGRGSVAG---SVGCCSERQEEDgLEFLDNLEPKFRTLAE 896
Cdd:pfam01049  11 DSLQTYAYEGDGSSAGslsSLESSTSDSDQD-YDYLSDWGPRFKKLAE 57
Cadherin_pro pfam08758
Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent ...
 36-96 9.86e-05

Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions.


Pssm-ID: 462590  Cd Length: 90  Bit Score: 41.93  E-value: 9.86e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 13435364    36 TLHVPSKLDAEKLVGRVNLKECFTAANLIH-SSDPDFQILEDGSVYTTNTILLSSEKRSFTI 96
Cdd:pfam08758  12 TFSVPRRLEEGQPLLNVKFNDCTGRKKTLYeSSDPRFKVNTDGTVTAKRPVTLHGRQTSFLV 73
 
Name Accession Description Interval E-value
Cadherin_pro smart01055
Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent ...
 31-111 1.01e-29

Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions.


Pssm-ID: 214999  Cd Length: 87  Bit Score: 112.76  E-value: 1.01e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13435364     31 ACKNVTLHVPSKLDAEKLVGRVNLKECFTAANL-IHSSDPDFQILEDGSVYTTNTILLSSEKRSFTILLSNTENQEKKKI 109
Cdd:smart01055   6 SEEKYTFHVPSHLEAGQPLGRVNFEECLGSARLqFESSDPDFRVLEDGTVYATRPVSLSSEKKSFTVLAWDSQGQEKKEI 85


                   ..
gi 13435364    110 FV 111
Cdd:smart01055  86 KV 87
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 247-351 1.36e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 104.32  E-value: 1.36e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13435364 247 TYTFTIFENCRVGTTVGQVCATDKDEPdtMHTRLKYSIIGQVPPSptLFSMHPTTGVITTTSSqLDRELIDKYQLKIKVQ 326
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSG--ENGEVTYSIVSGNEDG--LFSIDPSTGEITTAKP-LDREEQSSYTLTVTAT 75

                        90       100
                ....*....|....*....|....*
gi 13435364 327 DMDGQyfGLQTTSTCIINIDDVNDH 351
Cdd:cd11304  76 DGGGP--PLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
248-345 8.20e-21

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 87.74  E-value: 8.20e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13435364   248 YTFTIFENCRVGTTVGQVCATDKDEPDtmHTRLKYSIIGQvpPSPTLFSMHPTTGVITTTsSQLDRELIDKYQLKIKVQD 327
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGP--NGRIFYSILGG--GPGGNFRIDPDTGDISTT-KPLDRESIGEYELTVEATD 75

                          90
                  ....*....|....*...
gi 13435364   328 MDGQyfGLQTTSTCIINI 345
Cdd:pfam00028  76 SGGP--PLSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
360-463 5.56e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 79.65  E-value: 5.56e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13435364   360 YVTSVEENT-VDVEILRVTVEDKDLvnTANWRANYTILKGNENGNFKIVTDAktneGVLCVVKPLNYEEKQQMILQIGVV 438
Cdd:pfam00028   1 YSASVPENApVGTEVLTVTATDPDL--GPNGRIFYSILGGGPGGNFRIDPDT----GDISTTKPLDRESIGEYELTVEAT 74

                          90       100
                  ....*....|....*....|....*
gi 13435364   439 NEAPFSREasprsamSTATVTVNVE 463
Cdd:pfam00028  75 DSGGPPLS-------STATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 267-353 6.59e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 78.93  E-value: 6.59e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13435364    267 ATDKDEPDtmHTRLKYSIIGQVPPSPtlFSMHPTTGVITTTSsQLDRELIDKYQLKIKVQDMDGQyfGLQTTSTCIINID 346
Cdd:smart00112   2 ATDADSGE--NGKVTYSILSGNDDGL--FSIDPETGEITTTK-PLDREEQPEYTLTVEATDGGGP--PLSSTATVTITVL 74


                   ....*..
gi 13435364    347 DVNDHLP 353
Cdd:smart00112  75 DVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 359-467 1.37e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 78.89  E-value: 1.37e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13435364 359 SYVTSVEENT-VDVEILRVTVEDKDLvnTANWRANYTILKGNENGNFKIvtDAKTneGVLCVVKPLNYEEKQQMILQIGV 437
Cdd:cd11304   1 SYEVSVPENApPGTVVLTVSATDPDS--GENGEVTYSIVSGNEDGLFSI--DPST--GEITTAKPLDREEQSSYTLTVTA 74

                        90       100       110
                ....*....|....*....|....*....|
gi 13435364 438 VNEAPFSREasprsamSTATVTVNVEDQDE 467
Cdd:cd11304  75 TDGGGPPLS-------STATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 477-573 1.41e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 75.81  E-value: 1.41e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13435364 477 TVRMKENAEVGTTSNGYKAYDPETRSSSGIRYKKLT-DPTGWVTIDENTGSIKVFRSLDREaetiKNGIYNITVLASDQG 555
Cdd:cd11304   3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSgNEDGLFSIDPSTGEITTAKPLDRE----EQSSYTLTVTATDGG 78

                        90       100
                ....*....|....*....|
gi 13435364 556 G--RTCTGTLGIILQDVNDN 573
Cdd:cd11304  79 GppLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
476-568 3.99e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 74.26  E-value: 3.99e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13435364   476 QTVRMKENAEVGTTSNGYKAYDPETRSSSGIRYKKL-TDPTGWVTIDENTGSIKVFRSLDREAetikNGIYNITVLASDQ 554
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILgGGPGGNFRIDPDTGDISTTKPLDRES----IGEYELTVEATDS 76

                          90
                  ....*....|....*.
gi 13435364   555 G--GRTCTGTLGIILQ 568
Cdd:pfam00028  77 GgpPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 494-575 2.05e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 72.00  E-value: 2.05e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13435364    494 KAYDPETRSSSGIRYKKLT-DPTGWVTIDENTGSIKVFRSLDREaetiKNGIYNITVLASDQGG--RTCTGTLGIILQDV 570
Cdd:smart00112   1 SATDADSGENGKVTYSILSgNDDGLFSIDPETGEITTTKPLDRE----EQPEYTLTVEATDGGGppLSSTATVTITVLDV 76


                   ....*
gi 13435364    571 NDNSP 575
Cdd:smart00112  77 NDNAP 81
Cadherin pfam00028
Cadherin domain;
140-234 5.92e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 71.18  E-value: 5.92e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13435364   140 IPCSMLENSL-GPFPLFLQQVQSDTAQNYTIYYSIRGPGVDqeprNLFYVERDTGNLYCTRPVDREQYESFEIIAFATTP 218
Cdd:pfam00028   1 YSASVPENAPvGTEVLTVTATDPDLGPNGRIFYSILGGGPG----GNFRIDPDTGDISTTKPLDRESIGEYELTVEATDS 76

                          90
                  ....*....|....*.
gi 13435364   219 DGYTPELPLPLIIKIE 234
Cdd:pfam00028  77 GGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 161-241 7.69e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 64.68  E-value: 7.69e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13435364    161 SDTAQNYTIYYSIrgpgVDQEPRNLFYVERDTGNLYCTRPVDREQYESFEIIAFATTPDGYTPELPLPLIIKIEDENDNY 240
Cdd:smart00112   5 ADSGENGKVTYSI----LSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                   .
gi 13435364    241 P 241
Cdd:smart00112  81 P 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 162-239 2.02e-12

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 63.87  E-value: 2.02e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13435364 162 DTAQNYTIYYSIrgpgVDQEPRNLFYVERDTGNLYCTRPVDREQYESFEIIAFATtpDGYTPEL--PLPLIIKIEDENDN 239
Cdd:cd11304  25 DSGENGEVTYSI----VSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTAT--DGGGPPLssTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 377-474 9.62e-12

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 61.60  E-value: 9.62e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13435364    377 TVEDKDLvnTANWRANYTILKGNENGNFKIvtDAKTneGVLCVVKPLNYEEKQQMILQIGVVNEAPFSREasprsamSTA 456
Cdd:smart00112   1 SATDADS--GENGKVTYSILSGNDDGLFSI--DPET--GEITTTKPLDREEQPEYTLTVEATDGGGPPLS-------STA 67

                           90
                   ....*....|....*...
gi 13435364    457 TVTVNVEDQDEgpecNPP 474
Cdd:smart00112  68 TVTITVLDVND----NAP 81
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 140-239 9.12e-10

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 56.58  E-value: 9.12e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13435364 140 IPCSMLENSLGPfpLFLQQVQSDTAQNYTIYYSIRGPGVDQEPrNLFYVERDTGNLYCTRPVDREQYESFEIIAFATTPD 219
Cdd:cd00031   2 PDGSAVEGRSRG--SFRVSIPTDLIASSGEIIKISAAGKEALP-SWLHWEPHSGILEGLEKLDREDKGVHYISVSAASLG 78

                        90       100
                ....*....|....*....|
gi 13435364 220 GYTPELPLPLIIKIEDENDN 239
Cdd:cd00031  79 ANVPQTSSVFSIEVYDENDN 98
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 852-896 3.60e-08

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


Pssm-ID: 460041  Cd Length: 60  Bit Score: 50.61  E-value: 3.60e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 13435364   852 DYVLTYNYEGRGSVAG---SVGCCSERQEEDgLEFLDNLEPKFRTLAE 896
Cdd:pfam01049  11 DSLQTYAYEGDGSSAGslsSLESSTSDSDQD-YDYLSDWGPRFKKLAE 57
Cadherin_pro pfam08758
Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent ...
 36-96 9.86e-05

Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions.


Pssm-ID: 462590  Cd Length: 90  Bit Score: 41.93  E-value: 9.86e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 13435364    36 TLHVPSKLDAEKLVGRVNLKECFTAANLIH-SSDPDFQILEDGSVYTTNTILLSSEKRSFTI 96
Cdd:pfam08758  12 TFSVPRRLEEGQPLLNVKFNDCTGRKKTLYeSSDPRFKVNTDGTVTAKRPVTLHGRQTSFLV 73
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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