Regulator of G protein signaling (RGS) domain found in the Axin protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the Axin protein. Axin is a member of the RA/RGS subfamily of the RGS protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, and skeletal and muscle development. The RGS domain of Axin is specifically interacts with the heterotrimeric G-alpha12 protein, but not with closely related G-alpha13, and provides a unique tool to regulate G-alpha12-mediated signaling processes. The RGS domain of Axin also interacts with the tumor suppressor protein APC (Adenomatous Polyposis Coli) in order to control the cytoplasmic level of the proto-oncogene, beta-catenin.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13242326  94 LHSLLDDQDGISLFRTFLKQEGCADLLDFWFACSGFRKLEPCDsneEKRLKLARAIYRKYILDsNGIVSRQTKPATKSFI 173
Cdd:cd08707   1 LHSLLDDQDGIELFRTYLEQEGCADLLDFWFACNGFRKMSDSE---EKRSKLAKAIYRRYIKD-NGIVSRQLKPATKSFI 76

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 13242326 174 KDCVMKQQIDPAMFDQAQTEIQSTMEENTYPSFLKSDIYLE 214
Cdd:cd08707  77 KECIKKQQLDPAMFDQAQTEIQTTMEENTYPSFLKSDIYLE 117

Tankyrase binding N-terminal segment of axin; This N-terminal region of axin mediates interactions with the ankyrin-repeat clusters 2 and 3 of tankyrase, which controls the turnover of axin via poly-ADP-ribosylation. Axin functions as a negative regulator of the WNT signaling pathway.

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13242326  16 DLGASFTEDAPRPPVPGEEGELVSTDSRPVNHSFcSGKGTSIKSETSTATPRRSDLDLGYEPEGSASPTP 85
Cdd:cd11582   1 DPGSSFREDAPRPPVPGEEGELTPSDPRSSSHSY-SNKSDSLKPEPSAATPRRIEAPLGFEPEGSASPTP 69

Regulator of G protein signaling (RGS) domain found in the Axin protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the Axin protein. Axin is a member of the RA/RGS subfamily of the RGS protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, and skeletal and muscle development. The RGS domain of Axin is specifically interacts with the heterotrimeric G-alpha12 protein, but not with closely related G-alpha13, and provides a unique tool to regulate G-alpha12-mediated signaling processes. The RGS domain of Axin also interacts with the tumor suppressor protein APC (Adenomatous Polyposis Coli) in order to control the cytoplasmic level of the proto-oncogene, beta-catenin.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13242326  94 LHSLLDDQDGISLFRTFLKQEGCADLLDFWFACSGFRKLEPCDsneEKRLKLARAIYRKYILDsNGIVSRQTKPATKSFI 173
Cdd:cd08707   1 LHSLLDDQDGIELFRTYLEQEGCADLLDFWFACNGFRKMSDSE---EKRSKLAKAIYRRYIKD-NGIVSRQLKPATKSFI 76

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 13242326 174 KDCVMKQQIDPAMFDQAQTEIQSTMEENTYPSFLKSDIYLE 214
Cdd:cd08707  77 KECIKKQQLDPAMFDQAQTEIQTTMEENTYPSFLKSDIYLE 117

Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13242326     93 SLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACSGFRKLEpcdsNEEKRLKLARAIYRKYIlDSNGIVSRQTKPATKSF 172
Cdd:smart00315   1 SLESLLSDPIGRLLFREFLESEFSEENLEFWLAVEEFKKAE----DDEERIAKAREIYDKFL-SPNAPKEVNLDSDLREK 75

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 13242326    173 IKDCVMKQQIDPAMFDQAQTEIQSTMEENTYPSFLKSDIYLEY 215
Cdd:smart00315  76 IEENLESEEPPPDLFDEAQREVYELLEKDSFPRFLESDYYLRF 118

Domain present in Dishevelled and axin; Domain of unknown function.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13242326    750 CDSIVVAYYFCGEPIPYRTLVRGRA--VTLGQFKELLTKKGsYRYYFKKVSDEFDcGVVFEEVREDEAILPVFEEKIIGK 827
Cdd:smart00021   1 CSETKVIYHLDDEETPYLVKVPVPAerVTLGDFKEVLTKKN-YKYYFKSMDDDFG-GVVKEEIRDDSARLPCFNGRVVSW 78

                   ....*
gi 13242326    828 VEKVD 832
Cdd:smart00021  79 LVSVE 83

Axin-1 tankyrase binding domain; This is the N-terminal domain tankyrase binding domain of Axin-1.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 13242326    16 DLGASFTEDAPRPPVPGEEGELVSTDSRPVNHSFCSGKGTSIKSETSTATPRRSDLDLGYEPEGSASPTPPY 87
Cdd:pfam16646   4 DGGGSFREDAPRPPVPGEEGEVPGCGPQHGSFGPSSKKEALKKEASVASTPRRNEDGLGEEPEGSASPDPPL 75

Regulator of G protein signaling (RGS) domain found in the Axin protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the Axin protein. Axin is a member of the RA/RGS subfamily of the RGS protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, and skeletal and muscle development. The RGS domain of Axin is specifically interacts with the heterotrimeric G-alpha12 protein, but not with closely related G-alpha13, and provides a unique tool to regulate G-alpha12-mediated signaling processes. The RGS domain of Axin also interacts with the tumor suppressor protein APC (Adenomatous Polyposis Coli) in order to control the cytoplasmic level of the proto-oncogene, beta-catenin.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13242326  94 LHSLLDDQDGISLFRTFLKQEGCADLLDFWFACSGFRKLEPCDsneEKRLKLARAIYRKYILDsNGIVSRQTKPATKSFI 173
Cdd:cd08707   1 LHSLLDDQDGIELFRTYLEQEGCADLLDFWFACNGFRKMSDSE---EKRSKLAKAIYRRYIKD-NGIVSRQLKPATKSFI 76

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 13242326 174 KDCVMKQQIDPAMFDQAQTEIQSTMEENTYPSFLKSDIYLE 214
Cdd:cd08707  77 KECIKKQQLDPAMFDQAQTEIQTTMEENTYPSFLKSDIYLE 117

Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13242326     93 SLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACSGFRKLEpcdsNEEKRLKLARAIYRKYIlDSNGIVSRQTKPATKSF 172
Cdd:smart00315   1 SLESLLSDPIGRLLFREFLESEFSEENLEFWLAVEEFKKAE----DDEERIAKAREIYDKFL-SPNAPKEVNLDSDLREK 75

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 13242326    173 IKDCVMKQQIDPAMFDQAQTEIQSTMEENTYPSFLKSDIYLEY 215
Cdd:smart00315  76 IEENLESEEPPPDLFDEAQREVYELLEKDSFPRFLESDYYLRF 118

Domain present in Dishevelled and axin; Domain of unknown function.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13242326    750 CDSIVVAYYFCGEPIPYRTLVRGRA--VTLGQFKELLTKKGsYRYYFKKVSDEFDcGVVFEEVREDEAILPVFEEKIIGK 827
Cdd:smart00021   1 CSETKVIYHLDDEETPYLVKVPVPAerVTLGDFKEVLTKKN-YKYYFKSMDDDFG-GVVKEEIRDDSARLPCFNGRVVSW 78

                   ....*
gi 13242326    828 VEKVD 832
Cdd:smart00021  79 LVSVE 83

Tankyrase binding N-terminal segment of axin; This N-terminal region of axin mediates interactions with the ankyrin-repeat clusters 2 and 3 of tankyrase, which controls the turnover of axin via poly-ADP-ribosylation. Axin functions as a negative regulator of the WNT signaling pathway.

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13242326  16 DLGASFTEDAPRPPVPGEEGELVSTDSRPVNHSFcSGKGTSIKSETSTATPRRSDLDLGYEPEGSASPTP 85
Cdd:cd11582   1 DPGSSFREDAPRPPVPGEEGELTPSDPRSSSHSY-SNKSDSLKPEPSAATPRRIEAPLGFEPEGSASPTP 69

Regulator of G protein signaling (RGS) domain found in the RGS3 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS3 protein. RGS3 is a member of the R4/RGS subfamily of the RGS family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G-alpha subunit which leads to G protein deactivation and promotes desensitization. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes. RGS3 induces apoptosis when overexpressed and is involved in cell migration through interaction with the Ephrin receptor. RGS3 exits as several splice isoforms and interacts with neuroligin, estrogen receptor-alpha, and 14-3-3 outside of the GPCR pathways.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13242326  94 LHSLLDDQDGISLFRTFLKQEGCADLLDFWFACSGFRKLEPcdsnEEKRLKLARAIYRKYI---------LDSngivsrq 164
Cdd:cd08713   1 LEKLLLHKYGLAVFRAFLQTEFSEENLEFWLACEEYKKIKS----QSKMASRAKKIFAEYIaiqsckevnLDS------- 69

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 13242326 165 tkpATKSFIKDCVmkQQIDPAMFDQAQTEIQSTMEENTYPSFLKSDIYLE 214
Cdd:cd08713  70 ---YTREHTKENL--QNPTRGCFDLAQKRIYGLMEKDSYPRFLRSDLYQD 114

Regulator of G protein signaling (RGS) domain found in the RGS1 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS1 protein. RGS1 is a member of the R4/RGS subfamily of the RGS family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G-alpha subunit which leads to G protein deactivation and promotes desensitization. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS 1 is expressed predominantly in hematopoietic compartments, including T and B lymphocytes, and may play a major role in chemokine-mediated homing of lymphocytes to secondary lymphoid organs. In addition, RGS1 interacts with calmodulin and 14-3-3 protein outside of the GPCR pathway.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13242326  94 LHSLLDDQDGISLFRTFLKQEGCADLLDFWFACSGFRKLEpcdsNEEKRLKlARAIYRKYIlDSNGI----VSRQTKPAT 169
Cdd:cd08715   1 LEKLLASQTGQNVFRSFLKSEFSEENIEFWLACEDYKKTE----SDLLPCK-AEEIYKEFV-QSDAAkqinIDFRTREST 74

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 13242326 170 KSFIKDCVmkqqidPAMFDQAQTEIQSTMEENTYPSFLKSDIYL 213
Cdd:cd08715  75 AKKIKAPT------PTCFDEAQKVIYILMERDSYPRFLKSDIYL 112

Regulator of G protein signaling (RGS) domain found in the RGS10 protein; RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS10 protein. RGS10 is a member of the RA/RGS subfamily of RGS proteins family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS10 belong to the R12 RGS subfamily, which includes RGS12 and RGS14, all of which are highly selective for G-alpha-i1 over G-alpha-q. RGS10 exists in 2 splice isoforms. RGS10A is specifically expressed in osteoclasts and is a key component in the RANKL signaling mechanism for osteoclast differentiation, whereas RGS10B expressed in brain and in immune tissues and has been implicated in diverse processes including: promoting of dopaminergic neuron survival via regulation of the microglial inflammatory response, modulation of presynaptic and postsynaptic G-protein signalling, as well as a possible role in regulation of gene expression.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13242326  94 LHSLLDDQDGISLFRTFLKQEGCADLLDFWFACSGFRKLEpcdsNEEKRLKLARAIYRKYILDSngiVSRQTKPATKSFI 173
Cdd:cd08741   1 LENLLEDPEGVKRFREFLKKEFSEENVLFWLACEDFKKMQ----DKTQMQEKAKEIYMTFLSSK---ASSQVNVEGQSRL 73

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 13242326 174 KDCVMKQQiDPAMFDQAQTEIQSTMEENTYPSFLKSDIYLE 214
Cdd:cd08741  74 NEKILEEP-HPLMFQKLQDQIFNLMKYDSYSRFLKSDLFLK 113

Regulator of G protein signaling (RGS) domain found in the RGS19 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS19 protein (also known as GAIP), a member of the RZ subfamily of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. Deactivation of G-protein signaling is controlled by RGS domains, which accelerate GTPase activity of the alpha subunit by hydrolysis of GTP to GDP, resulting in a reassociation of the alpha-subunit with the beta-gamma-dimer and an inhibition of downstream activity. As a major G-protein regulator, the RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. The RZ subfamily of RGS proteins includes RGS17, RGS20, and its splice variant Ret-RGS. RGS19 participates in regulation of dopamine receptor D2R and D3R, as well as beta-adrenergic receptors .

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13242326  90 WAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACSGFRKLEPCDSNEEKrlklARAIYRKYIldsnGIVSRQtKPAT 169
Cdd:cd08745   1 WAQSFDKLMKSPAGRNVFREFLRTEYSEENMLFWLACEELKAEANKHVIDEK----ARLIYEDYI----SILSPK-EVSL 71

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 13242326 170 KSFIKDCVMKQQIDPA--MFDQAQTEIQSTMEENTYPSFLKSDIY 212
Cdd:cd08745  72 DSRVREGINRKMQEPSshTFDDAQLQIYTLMHRDSYPRFLNSPIY 116

Regulator of G protein signaling (RGS) domain found in the RGS20 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS20 protein (also known as RGSZ1), a member of the RZ subfamily of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. Deactivation of G-protein signaling is controlled by the RGS domain, which accelerates GTPase activity of the alpha subunit by hydrolysis of GTP to GDP resulting in reassociation of the alpha-subunit with the beta-gamma-dimer and inhibition of downstream activity. As a major G-protein regulator, the RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. The RZ subfamily of RGS proteins include RGS17, RGS19 (former GAIP), and the splice variant of RGS20, Ret-RGS. RGS20 is expressed exclusively in brain, with the highest concentrations in the temporal lobe and the caudate nucleus and may play a role in signaling regulation in these brain regions. RGS20 acts as a GAP of both G-alpha-z and G-alpha-I and controls signaling in the mu opioid receptor pathway.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13242326  67 RRSDLDLGYE--PEGSASPTPPYLR---WAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACSGFRKLEPCDSNEEK 141
Cdd:cd08746  22 RRTSYEFRAEgiPNCEESPKPTLEEvcaWGQSFDKLMLTPAGRNAFREFLRTEFSEENMLFWMACEELKKEANKSVIEEK 101

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 13242326 142 rlklARAIYRKYIldsnGIVSRQtKPATKSFIKDCVMKQQIDPA--MFDQAQTEIQSTMEENTYPSFLKSDIY 212
Cdd:cd08746 102 ----ARIIYEDYI----SILSPK-EVSLDSRVREVINRNMLEPSqhTFDDAQLQIYTLMHRDSYPRFMNSAIY 165

Regulator of G protein signaling (RGS) domain found in the RGS8 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS8 protein. RGS8 is a member of R4/RGS subfamily of RGS family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G-alpha subunit which leads to G protein deactivation and promotes desensitization. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS8 is involved in G-protein-gated potassium channels regulation and predominantly expressed in the brain. RGS8 also is selectively expressed in the hematopoietic system (NK cells).

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13242326  89 RWAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACSGFRKLEpcdsNEEKRLKLARAIYRKYI---LDSNGIVSRQT 165
Cdd:cd08711   7 RWADSFDVLLSHKYGVAAFRAFLKTEFSEENLEFWLACEEFKKTR----STAKLVSKAHRIFEEFVdvqAPREVNIDFQT 82

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 13242326 166 KPATKSFIkdcvmkQQIDPAMFDQAQTEIQSTMEENTYPSFLKSDIYLE 214
Cdd:cd08711  83 REATRKNL------QEPSLTCFDQAQGKVHSLMEKDSYPRFLRSKMYLD 125

Regulator of G protein signaling (RGS) domain found in the RGS4 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS4 protein. RGS4 is a member of the R4/RGS subfamily of the RGS family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G-alpha subunit which leads to G protein deactivation and promotes desensitization. RGS4 is expressed widely in brain including prefrontal cortex, striatum, locus coeruleus (LC), and hippocampus and has been implicated in regulation of opioid, cholinergic, and serotonergic signaling. Dysfunctions in RGS4 proteins are involved in etiology of Parkinson's disease, addiction, and schizophrenia. RGS4 also is up-regulated in the failing human heart. RGS4 interacts with many binding partners outside of GPCR pathways, including calmodulin, COP, Kir3, PIP, calcium/CaM, PA, ErbB3, and 14-3-3.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13242326  94 LHSLLDDQDGISLFRTFLKQEGCADLLDFWFACSGFRKLEPCDSNEEKrlklARAIYRKYIldsngivsrqTKPATKSFI 173
Cdd:cd08714   1 LENLINHECGLAAFKAFLKSEYSEENIDFWVSCEDYKKTKSPSKLSPK----ARKIYEEFI----------SVQATKEVN 66

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 13242326 174 KDCVMKQQIDPAM-------FDQAQTEIQSTMEENTYPSFLKSDIYLE 214
Cdd:cd08714  67 LDSCTREETSRNMleptiscFDEAQKKIFTLMEKDSYRRFLKSRFYLD 114

Regulator of G protein signaling (RGS) domain found in the RGS16 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS16 protein. RGS16 is a member of the RGS protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G-alpha subunit which leads to G protein deactivation and promotes desensitization. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS16 is a member of the R4/RGS subfamily and interacts with neuronal G-alpha0. RGS16 expression is upregulated by IL-17 of the NF-kappaB signaling pathway in autoimmune B cells.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13242326  97 LLDDQDGISLFRTFLKQEGCADLLDFWFACSGFRKLEpcdsNEEKRLKLARAIYRKYIL-----DSNgiVSRQTKPATKS 171
Cdd:cd08710   4 LLNSKNGVAAFHAFLKTEFSEENLEFWLACEEFKKIR----SATKLASRAHHIFEEFIRseapkEVN--IDHETRELTRT 77

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 13242326 172 FIkdcvmkQQIDPAMFDQAQTEIQSTMEENTYPSFLKSDIY 212
Cdd:cd08710  78 NL------QAATTSCFDVAQGKTRTLMEKDSYPRFLKSPAY 112

Regulator of G protein signaling (RGS) domain found in the RGS17 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS17 protein, a member of the RZ subfamily of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, the RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. Deactivation of the G-protein signaling controlled by the RGS domain, which accelerates GTPase activity of the alpha subunit by hydrolysis of GTP to GDP, results in reassociation of the alpha-subunit with the beta-gamma-dimer and inhibition of downstream activity. The RZ subfamily of RGS proteins includes RGS19 (former GAIP), RGS20, and its splice variant Ret-RGS. RGS17 is a relatively non-selective GAP for G-alpha-z and other G-alpha-i/o proteins. RGS17 blocks dopamine receptor-mediated inhibition of cAMP accumulation; it also blocks thyrotropin releasing hormone-stimulated Ca++ mobilization. RGS17, like other members of RZ subfamily, can act either as a GAP or as G-protein effector antogonist.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13242326  90 WAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACSGFRKLEPCDSNEEKrlklARAIYRKYIldsnGIVSRQtKPAT 169
Cdd:cd08744   1 WSQNFDKMMKTPAGRNLFREFLRTEYSEENLLFWLACEDLKKEQNKKVIEEK----ARLIYEDYI----SILSPK-EVSL 71

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 13242326 170 KSFIKDCVMKQQIDPA--MFDQAQTEIQSTMEENTYPSFLKSDIY 212
Cdd:cd08744  72 DSRVREVINRNLLDPNphMYEDAQLQIYTLMHRDSFPRFLNSQIY 116

Regulator of G protein signaling (RGS) domain found in the R7 subfamily of proteins; The RGS (Regulator of G-protein Signaling) domain is an essential part of the R7 (Neuronal RGS) protein subfamily of the RGS protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. The R7 subfamily includes RGS6, RGS7, RGS9, and RGS11, all of which, in humans, are expressed predominantly in the nervous system, form an obligatory complex with G-beta-5, and play important roles in the regulation of crucial neuronal processes. In addition, R7 proteins were found to bind many other proteins outside of the G protein signaling pathways including: m-opioid receptor, beta-arrestin, alpha-actinin-2, NMDAR, polycystin, spinophilin, guanylyl cyclase, among others.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13242326  89 RWAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACSGFRKlepCDSNEEKRlkLARAIYRKYI---------LDSNg 159
Cdd:cd08705   4 RWGFSFSELLKDPVGREQFLKFLEKEFSGENLRFWEACQDLKY---GPQSQVPE--KVQEIYQEFLapgapswinIDSK- 77

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 13242326 160 ivsrqtkpatksfIKDCVMKQQIDPA--MFDQAQTEIQSTMEENTYPSFLKSDIY 212
Cdd:cd08705  78 -------------TMEITLKNLKDPHryTFDAAQEHIYMLMKKDSYPRFLRSDIY 119

Regulator of G protein signaling (RGS) domain found in the RGS9 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS9 protein, a member of R7 subfamily of the RGS protein family. RGS is a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. Other members of the R7 subfamily (Neuronal RGS) include: RGS6, RGS7, and RGS11, all of which are expressed predominantly in the nervous system, form an obligatory complex with G-beta-5, and play important roles in the regulation of crucial neuronal processes such as vision and motor control. Additionally they have been implicated in many neurological conditions such as anxiety, schizophrenia, and drug dependence. RGS9 forms constitutive complexes with G-beta-5 subunit and controls such fundamental functions as vision and behavior. RGS9 exists in two splice isoforms: RGS9-1 which regulates phototransduction in rods and cones and RGS9-2 which regulates dopamine and opioid signaling in the basal ganglia. In addition, RGS9 was found to bind many other proteins outside of G protein signaling pathways including: mu-opioid receptor, beta-arrestin, alpha-actinin-2, NMDAR, polycystin, spinophilin, and guanylyl cyclase, among others.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13242326  89 RWAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACSGFRKlepcdSNEEKRLKLARAIYRKYIldsngivsrqtKPA 168
Cdd:cd08739   4 RWAFNFSELIRDPKGRQSFQLFLKKEFSGENLGFWEACEDLKY-----GDQSKVKEKAEEIYKLFL-----------APG 67

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 13242326 169 TKSFIK------DCVMKQQIDPAMF--DQAQTEIQSTMEENTYPSFLKSDIYLE 214
Cdd:cd08739  68 ARRWINidgktmDITVKGLKHPHRYvlDAAQTHIYMLMKKDSYARYLKSPIYKE 121

Regulator of G protein signaling (RGS) domain found in the Sorting Nexin14 (SNX14) protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the SNX14 (Sorting Nexin14) protein, a member of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. SNX14 is believed to regulates membrane trafficking in motor neurons.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13242326  98 LDDQDGISLFRTFLKQEGCADLLDFWFACSGF--RKLEPcDSNEEKRLKL---ARAIYRKYILD------------SNGI 160
Cdd:cd08722   2 LDDQRLLFPFMQFLKEEGAVHLLQFCLTVEDFnrRILNP-DLTDEEKQSLhkeAQEIYKTYFLPeapdrihfppdiVEEI 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 13242326 161 VSRQTKPATKsfikdcVMKQQIDPAMFdQAQTEIQSTMEENTYPSFLKSDIYLE 214
Cdd:cd08722  81 KQILEGGPEK------IVKLRTSRPLF-EAYEHVYSLLESVFCPLFCHSDEYFI 127

Regulator of G protein signaling domain (RGS) found in G protein-coupled receptor kinase 2 (GRK2) and G protein-coupled receptor kinase 3 (GRK3); The RGS domain is an essential part of the GRK2 (G protein-coupled receptor kinases 2) and the GRK3 proteins, which are members of the beta-adrenergic receptor kinases subfamily. GRK2 and GRK3 are ubiquitously expressed and can phosphorylate many different GPCR. The C-terminus of GRK2 and 3 contains a plekstrin homology domain (PH) with binding sites for the membrane phospholipid PIP2 and free G#? subunits. These specific interactions could help to maintain a membrane-bound population of GRK2 prior to the agonist-dependent overt GRK2 translocation. GRK2 and GRK3 are members of the GRK kinase family which includes three major subfamilies: the GRK4 subfamily (GRK4, GRK5 and GRK6), the rhodopsin kinase or visual GRK subfamily (GRK1 and GRK7), and the beta-adrenergic receptor kinases subfamily (GRK2/GRK3). The RGS domain of the GRKs has very little sequence similarity with the canonical RGS domain of the RGS proteins and therefore is often refered to as the RH (RGS Homology) domain. RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13242326 103 GISLFRTFLKQ--EGCADLLDFWFACSGFRKLEpcdsNEEKRLKLARAIYRKYILDSngIVSrQTKPATKS---FIKDCV 177
Cdd:cd08747  35 GYLLFKDFCENvsEEPVPQLKFYEEIKKYEKLD----TEEERIKKAREIYDNYIMKE--LLS-CSHPFSKSaveHVQKHL 107

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 13242326 178 MKQQIDPAMFDQAQTEIQSTMEENTYPSFLKSDiylEYTR 217
Cdd:cd08747 108 SKKEVPVDLFEPYIEEICDSLRGDVFQKFLESD---KFTR 144

Uncharacterized Regulator of G protein Signaling (RGS) domain subfamily, child 3; These uncharacterized RGS-like domains consists largely of hypothetical proteins. The RGS domain is an essential part of the Regulator of G-protein Signaling (RGS) protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory role as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. As a major G-protein regulator, the RGS domain containing proteins that are involved in many crucial cellular processes. RGS proteins play critical regulatory role as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. Several RGS proteins can fine-tune immune responses, while others play an important role in neuronal signal modulation. Some RGS proteins are the principal elements needed for proper vision.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13242326 103 GISLFRTFLKQEGCADLLDFWFACSGFRKlEPCdSNEEKRLKLARAIYRKYILdsngivsrqtkpaTKSFIKDCVMKQQI 182
Cdd:cd08730   7 GMRRFRQFLAGTLGEDYLKFWLDVEMYRR-DYK-FGEIKRLDFFRSVVTKYLL-------------KNSPYCLPVFKRIE 71

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13242326 183 DPAMFDQ-AQTEIQSTMeentypSFLKSDIYLEYTRTGSESPKVCSDQSSGSGTGKGMSGYLPtlnEDEEWKCDQDADED 261
Cdd:cd08730  72 SNIGLDEsAIMEVMSPM------TEMPWQLLVYQMEVLSSTDTETTDGSTLEDLKRSYCEYIQ---QEALFILDDANHEV 142

                       170       180       190
                ....*....|....*....|....*....|.
gi 13242326 262 dgrdsvppsrLTQKLLLETA-APRAPSSRRY 291
Cdd:cd08730 143 ----------SRQTVLIPTQmSARLSNGLTS 163

Regulator of G protein signaling domain; These uncharacterized RGS-like domains are found in proteins that also contain one or more PX domains. The RGS domain is an essential part of the Regulator of G-protein Signaling (RGS) protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory role as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. As a major G-protein regulator, the RGS domain containing proteins that are involves in many crucial cellular processes. RGS proteins regulate intracellular trafficking and provide vital support for signal transduction. RGS proteins play critical regulatory role as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. Several RGS proteins can fine-tune immune responses, others RGS proteins play important role in neuronal signals modulation. Some RGS proteins are the principal elements needed for proper vision.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13242326  98 LDDQDGISLFRTFLKQEGCADLLDFWFACSGFRKLEPCDSNEEKRLKLA------------RAIYRKYILDSNGI--VSR 163
Cdd:cd08729   1 LRDPSSLSYFMEFMDRRNRSQLVQFWLVVEGFKNPLEDTENDYSLDSSQsrswidsdkediAMIYETYFSDPSPSlnVPK 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 13242326 164 QTKPATKSFIKdcvMKQQIDP---------AMFdQAQTEIQSTMEENTYPSFLKSDIYL 213
Cdd:cd08729  81 ASRDPIRLFLN---AGVNASPneqyrkarrAVL-MAQRAVYEEMEEEDFPEFKKSELFY 135

Regulator of G protein signaling (RGS) domain 1 found in the A-kinase anchoring protein, D-AKAP2; The RGS (Regulator of G-protein Signaling) domain is an essential part of the D-AKAP2 (A-kinase anchoring protein), a member of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. D-AKAP2 contains two RGS domains which play an important role in spatiotemporal localization of cAMP-dependent PKA (cyclic AMP-dependent protein kinase) that regulates many different signaling pathways by phosphorylation of target proteins. This cd contains the first RGS domain.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13242326  93 SLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACSGFR-------------------------------KLEPC------ 135
Cdd:cd08735   4 TLEQILHDNSALPYFIQFMETRRAEHLIKFWLEAESFKsaawsrirahslntvkhssleepvspsldrkVLESKstdsls 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13242326 136 ----DSNEEKRLKL----ARAIYRKYIldsngiVSRQTKP-----ATKSFI--KDCVMKQQIDPAMFDQAQTEIQSTMEE 200
Cdd:cd08735  84 qrltDDDDEKSMKSierdAVSIYTKYI------SPDAAKPipiteEIRNDIvaKICGEDGQVDPNCFVEAQSFVFSAMEQ 157

                       170
                ....*....|..
gi 13242326 201 NTYPSFLKSDIY 212
Cdd:cd08735 158 DHFTEFLRSHFF 169