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Conserved domains on  [gi|29150272|ref|NP_077168|]
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protein SEC13 homolog [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
25-289 1.36e-35

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 132.73  E-value: 1.36e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29150272  25 GTRLATCSSDRSVKIFDVRNGGqiLIADLRGHEGPVWQVAWAHPmyGNILASCSYDRKVIIWKEENGtwEKTHEHSGHDS 104
Cdd:COG2319 132 GKTLASGSADGTVRLWDLATGK--LLRTLTGHSGAVTSVAFSPD--GKLLASGSDDGTVRLWDLATG--KLLRTLTGHTG 205

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29150272 105 SVNSVCWAPHdyGLILACGSSDGAISLltYTGEGQWEVKKInNAHTIGCNAVSWAPAvvpGSLIdqpsgqkpnyikkfAS 184
Cdd:COG2319 206 AVRSVAFSPD--GKLLASGSADGTVRL--WDLATGKLLRTL-TGHSGSVRSVAFSPD---GRLL--------------AS 263

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29150272 185 GGCDNLIKLWREEEdgqWKEEQKLEAHSDWVRDVAWAPSiGlptSTIASCSQDGRVFIWtcddasgNMWSPKLLHKFN-- 262
Cdd:COG2319 264 GSADGTVRLWDLAT---GELLRTLTGHSGGVNSVAFSPD-G---KLLASGSDDGTVRLW-------DLATGKLLRTLTgh 329

                       250       260
                ....*....|....*....|....*...
gi 29150272 263 -DVVWHVSWSITANILAVSGGDNKVTLW 289
Cdd:COG2319 330 tGAVRSVAFSPDGKTLASGSDDGTVRLW 357
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
25-289 1.36e-35

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 132.73  E-value: 1.36e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29150272  25 GTRLATCSSDRSVKIFDVRNGGqiLIADLRGHEGPVWQVAWAHPmyGNILASCSYDRKVIIWKEENGtwEKTHEHSGHDS 104
Cdd:COG2319 132 GKTLASGSADGTVRLWDLATGK--LLRTLTGHSGAVTSVAFSPD--GKLLASGSDDGTVRLWDLATG--KLLRTLTGHTG 205

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29150272 105 SVNSVCWAPHdyGLILACGSSDGAISLltYTGEGQWEVKKInNAHTIGCNAVSWAPAvvpGSLIdqpsgqkpnyikkfAS 184
Cdd:COG2319 206 AVRSVAFSPD--GKLLASGSADGTVRL--WDLATGKLLRTL-TGHSGSVRSVAFSPD---GRLL--------------AS 263

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29150272 185 GGCDNLIKLWREEEdgqWKEEQKLEAHSDWVRDVAWAPSiGlptSTIASCSQDGRVFIWtcddasgNMWSPKLLHKFN-- 262
Cdd:COG2319 264 GSADGTVRLWDLAT---GELLRTLTGHSGGVNSVAFSPD-G---KLLASGSDDGTVRLW-------DLATGKLLRTLTgh 329

                       250       260
                ....*....|....*....|....*...
gi 29150272 263 -DVVWHVSWSITANILAVSGGDNKVTLW 289
Cdd:COG2319 330 tGAVRSVAFSPDGKTLASGSDDGTVRLW 357
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 10-289 3.30e-31

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 118.59  E-value: 3.30e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29150272  10 TSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGgqILIADLRGHEGPVWQVAWAHpmYGNILASCSYDRKVIIWKEE 89
Cdd:cd00200   6 KGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETG--ELLRTLKGHTGPVRDVAASA--DGTYLASGSSDKTIRLWDLE 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29150272  90 NGtwEKTHEHSGHDSSVNSVCWAPHDYglILACGSSDGAISLltytgegqWEVKKIN-----NAHTIGCNAVSWAPAvvp 164
Cdd:cd00200  82 TG--ECVRTLTGHTSYVSSVAFSPDGR--ILSSSSRDKTIKV--------WDVETGKclttlRGHTDWVNSVAFSPD--- 146

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29150272 165 gslidqpsgqkpnyiKKFASGGC-DNLIKLWREEEdgqWKEEQKLEAHSDWVRDVAWAPSiglpTSTIASCSQDGRVFIW 243
Cdd:cd00200 147 ---------------GTFVASSSqDGTIKLWDLRT---GKCVATLTGHTGEVNSVAFSPD----GEKLLSSSSDGTIKLW 204

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 29150272 244 tcdDASGNMWSpKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLW 289
Cdd:cd00200 205 ---DLSTGKCL-GTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVW 246
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 49-87 2.79e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.76  E-value: 2.79e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 29150272     49 LIADLRGHEGPVWQVAWAHpmYGNILASCSYDRKVIIWK 87
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSP--DGKYLASGSDDGTIKLWD 40
PTZ00420 PTZ00420
coronin; Provisional
 11-90 1.31e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 43.40  E-value: 1.31e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29150272   11 SHEDMIHDAQMD-YYGTRLATCSSDRSVKIFDVRNGGQIL--IAD----LRGHEGPVWQVAWaHPMYGNILASCSYDRKV 83
Cdd:PTZ00420  72 GHTSSILDLQFNpCFSEILASGSEDLTIRVWEIPHNDESVkeIKDpqciLKGHKKKISIIDW-NPMNYYIMCSSGFDSFV 150


                 ....*..
gi 29150272   84 IIWKEEN 90
Cdd:PTZ00420 151 NIWDIEN 157
WD40 pfam00400
WD domain, G-beta repeat;
202-243 5.21e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.94  E-value: 5.21e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 29150272   202 WKEEQKLEAHSDWVRDVAWAPSiglpTSTIASCSQDGRVFIW 243
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPD----GKLLASGSDDGTVKVW 38
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
25-289 1.36e-35

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 132.73  E-value: 1.36e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29150272  25 GTRLATCSSDRSVKIFDVRNGGqiLIADLRGHEGPVWQVAWAHPmyGNILASCSYDRKVIIWKEENGtwEKTHEHSGHDS 104
Cdd:COG2319 132 GKTLASGSADGTVRLWDLATGK--LLRTLTGHSGAVTSVAFSPD--GKLLASGSDDGTVRLWDLATG--KLLRTLTGHTG 205

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29150272 105 SVNSVCWAPHdyGLILACGSSDGAISLltYTGEGQWEVKKInNAHTIGCNAVSWAPAvvpGSLIdqpsgqkpnyikkfAS 184
Cdd:COG2319 206 AVRSVAFSPD--GKLLASGSADGTVRL--WDLATGKLLRTL-TGHSGSVRSVAFSPD---GRLL--------------AS 263

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29150272 185 GGCDNLIKLWREEEdgqWKEEQKLEAHSDWVRDVAWAPSiGlptSTIASCSQDGRVFIWtcddasgNMWSPKLLHKFN-- 262
Cdd:COG2319 264 GSADGTVRLWDLAT---GELLRTLTGHSGGVNSVAFSPD-G---KLLASGSDDGTVRLW-------DLATGKLLRTLTgh 329

                       250       260
                ....*....|....*....|....*...
gi 29150272 263 -DVVWHVSWSITANILAVSGGDNKVTLW 289
Cdd:COG2319 330 tGAVRSVAFSPDGKTLASGSDDGTVRLW 357
WD40 COG2319
WD40 repeat [General function prediction only];
25-289 2.42e-34

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 129.65  E-value: 2.42e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29150272  25 GTRLATCSSDRSVKIFDVRNGGqiLIADLRGHEGPVWQVAWAHPmyGNILASCSYDRKVIIWKEENGTWEKTHEhsGHDS 104
Cdd:COG2319 174 GKLLASGSDDGTVRLWDLATGK--LLRTLTGHTGAVRSVAFSPD--GKLLASGSADGTVRLWDLATGKLLRTLT--GHSG 247

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29150272 105 SVNSVCWAPHdyGLILACGSSDGAISLLTYTGegqWEVKKINNAHTIGCNAVSWApavvpgslidqPSGqkpnyiKKFAS 184
Cdd:COG2319 248 SVRSVAFSPD--GRLLASGSADGTVRLWDLAT---GELLRTLTGHSGGVNSVAFS-----------PDG------KLLAS 305

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29150272 185 GGCDNLIKLWREEEdgqWKEEQKLEAHSDWVRDVAWAPSiglpTSTIASCSQDGRVFIWtcdDASGNmWSPKLLHKFNDV 264
Cdd:COG2319 306 GSDDGTVRLWDLAT---GKLLRTLTGHTGAVRSVAFSPD----GKTLASGSDDGTVRLW---DLATG-ELLRTLTGHTGA 374

                       250       260
                ....*....|....*....|....*
gi 29150272 265 VWHVSWSITANILAVSGGDNKVTLW 289
Cdd:COG2319 375 VTSVAFSPDGRTLASGSADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
10-289 2.17e-33

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 126.95  E-value: 2.17e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29150272  10 TSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGqiLIADLRGHEGPVWQVAWAHPmyGNILASCSYDRKVIIWKEE 89
Cdd:COG2319  75 LGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGL--LLRTLTGHTGAVRSVAFSPD--GKTLASGSADGTVRLWDLA 150

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29150272  90 NGTWEKTheHSGHDSSVNSVCWAPhDyGLILACGSSDGAISLL-TYTGEGQWEVKkinnAHTIGCNAVSWAPAvvpGSLI 168
Cdd:COG2319 151 TGKLLRT--LTGHSGAVTSVAFSP-D-GKLLASGSDDGTVRLWdLATGKLLRTLT----GHTGAVRSVAFSPD---GKLL 219

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29150272 169 dqpsgqkpnyikkfASGGCDNLIKLWREEedgQWKEEQKLEAHSDWVRDVAWAPSiGlptSTIASCSQDGRVFIWtcdDA 248
Cdd:COG2319 220 --------------ASGSADGTVRLWDLA---TGKLLRTLTGHSGSVRSVAFSPD-G---RLLASGSADGTVRLW---DL 275

                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 29150272 249 SGNMWsPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLW 289
Cdd:COG2319 276 ATGEL-LRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLW 315
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 10-289 3.30e-31

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 118.59  E-value: 3.30e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29150272  10 TSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGgqILIADLRGHEGPVWQVAWAHpmYGNILASCSYDRKVIIWKEE 89
Cdd:cd00200   6 KGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETG--ELLRTLKGHTGPVRDVAASA--DGTYLASGSSDKTIRLWDLE 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29150272  90 NGtwEKTHEHSGHDSSVNSVCWAPHDYglILACGSSDGAISLltytgegqWEVKKIN-----NAHTIGCNAVSWAPAvvp 164
Cdd:cd00200  82 TG--ECVRTLTGHTSYVSSVAFSPDGR--ILSSSSRDKTIKV--------WDVETGKclttlRGHTDWVNSVAFSPD--- 146

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29150272 165 gslidqpsgqkpnyiKKFASGGC-DNLIKLWREEEdgqWKEEQKLEAHSDWVRDVAWAPSiglpTSTIASCSQDGRVFIW 243
Cdd:cd00200 147 ---------------GTFVASSSqDGTIKLWDLRT---GKCVATLTGHTGEVNSVAFSPD----GEKLLSSSSDGTIKLW 204

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 29150272 244 tcdDASGNMWSpKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLW 289
Cdd:cd00200 205 ---DLSTGKCL-GTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVW 246
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 7-290 6.57e-29

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 112.43  E-value: 6.57e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29150272   7 TVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGqiLIADLRGHEGPVWQVAWaHPMyGNILASCSYDRKVIIW 86
Cdd:cd00200  45 RTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGE--CVRTLTGHTSYVSSVAF-SPD-GRILSSSSRDKTIKVW 120

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29150272  87 KEENGtwEKTHEHSGHDSSVNSVCWAPHdyGLILACGSSDGAISLltytgegqWEVKKIN-----NAHTIGCNAVSWApa 161
Cdd:cd00200 121 DVETG--KCLTTLRGHTDWVNSVAFSPD--GTFVASSSQDGTIKL--------WDLRTGKcvatlTGHTGEVNSVAFS-- 186

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29150272 162 vvpgslidqPSGqkpnyiKKFASGGCDNLIKLWrEEEDGQWKEEqkLEAHSDWVRDVAWAPSIGLptstIASCSQDGRVF 241
Cdd:cd00200 187 ---------PDG------EKLLSSSSDGTIKLW-DLSTGKCLGT--LRGHENGVNSVAFSPDGYL----LASGSEDGTIR 244

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 29150272 242 IWtcddasgNMWSPKLLHKF---NDVVWHVSWSITANILAVSGGDNKVTLWK 290
Cdd:cd00200 245 VW-------DLRTGECVQTLsghTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
10-195 4.06e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 92.67  E-value: 4.06e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29150272  10 TSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGqiLIADLRGHEGPVWQVAWAHPmyGNILASCSYDRKVIIWkeE 89
Cdd:COG2319 243 TGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGE--LLRTLTGHSGGVNSVAFSPD--GKLLASGSDDGTVRLW--D 316

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29150272  90 NGTWEKTHEHSGHDSSVNSVCWAPHdyGLILACGSSDGAISLltYTGEGQWEVKKINnAHTIGCNAVSWAPAvvpGSLId 169
Cdd:COG2319 317 LATGKLLRTLTGHTGAVRSVAFSPD--GKTLASGSDDGTVRL--WDLATGELLRTLT-GHTGAVTSVAFSPD---GRTL- 387

                       170       180
                ....*....|....*....|....*.
gi 29150272 170 qpsgqkpnyikkfASGGCDNLIKLWR 195
Cdd:COG2319 388 -------------ASGSADGTVRLWD 400
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 49-87 2.79e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.76  E-value: 2.79e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 29150272     49 LIADLRGHEGPVWQVAWAHpmYGNILASCSYDRKVIIWK 87
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSP--DGKYLASGSDDGTIKLWD 40
WD40 COG2319
WD40 repeat [General function prediction only];
183-289 9.00e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 43.75  E-value: 9.00e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29150272 183 ASGGCDNLIKLWReeeDGQWKEEQKLEAHSDWVRDVAWAPsiglPTSTIASCSQDGRVFIWTCDDASgnmwSPKLLHKFN 262
Cdd:COG2319  52 AAGAGDLTLLLLD---AAAGALLATLLGHTAAVLSVAFSP----DGRLLASASADGTVRLWDLATGL----LLRTLTGHT 120

                        90       100
                ....*....|....*....|....*..
gi 29150272 263 DVVWHVSWSITANILAVSGGDNKVTLW 289
Cdd:COG2319 121 GAVRSVAFSPDGKTLASGSADGTVRLW 147
PTZ00420 PTZ00420
coronin; Provisional
 11-90 1.31e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 43.40  E-value: 1.31e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29150272   11 SHEDMIHDAQMD-YYGTRLATCSSDRSVKIFDVRNGGQIL--IAD----LRGHEGPVWQVAWaHPMYGNILASCSYDRKV 83
Cdd:PTZ00420  72 GHTSSILDLQFNpCFSEILASGSEDLTIRVWEIPHNDESVkeIKDpqciLKGHKKKISIIDW-NPMNYYIMCSSGFDSFV 150


                 ....*..
gi 29150272   84 IIWKEEN 90
Cdd:PTZ00420 151 NIWDIEN 157
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 201-243 1.41e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.83  E-value: 1.41e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 29150272    201 QWKEEQKLEAHSDWVRDVAWAPSiglpTSTIASCSQDGRVFIW 243
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPD----GKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
202-243 5.21e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.94  E-value: 5.21e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 29150272   202 WKEEQKLEAHSDWVRDVAWAPSiglpTSTIASCSQDGRVFIW 243
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPD----GKLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
49-86 5.52e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.94  E-value: 5.52e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 29150272    49 LIADLRGHEGPVWQVAWAHpmYGNILASCSYDRKVIIW 86
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSP--DGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 92-131 1.35e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.75  E-value: 1.35e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 29150272     92 TWEKTHEHSGHDSSVNSVCWAPHdyGLILACGSSDGAISL 131
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPD--GKYLASGSDDGTIKL 38
PTZ00420 PTZ00420
coronin; Provisional
 53-131 5.27e-03

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 38.39  E-value: 5.27e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29150272   53 LRGHEGPVWQVAWaHPMYGNILASCSYDRKVIIWK----EENGTWEKTHE--HSGHDSSVNSVCWAPHDYgLILACGSSD 126
Cdd:PTZ00420  70 LKGHTSSILDLQF-NPCFSEILASGSEDLTIRVWEiphnDESVKEIKDPQciLKGHKKKISIIDWNPMNY-YIMCSSGFD 147


                 ....*
gi 29150272  127 GAISL 131
Cdd:PTZ00420 148 SFVNI 152
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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