NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|50054384|ref|NP_076471|]
View 

macrophage colony-stimulating factor 1 precursor [Rattus norvegicus]

Protein Classification

CSF-1 and PRK14959 domain-containing protein( domain architecture ID 10526391)

protein containing domains CSF-1, PRK14959, and PHA03247

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
CSF-1 pfam05337
Macrophage colony stimulating factor-1 (CSF-1); Colony stimulating factor 1 (CSF-1) is a ...
 40-179 1.17e-87

Macrophage colony stimulating factor-1 (CSF-1); Colony stimulating factor 1 (CSF-1) is a homodimeric polypeptide growth factor whose primary function is to regulate the survival, proliferation, differentiation, and function of cells of the mononuclear phagocytic lineage. This lineage includes mononuclear phagocytic precursors, blood monocytes, tissue macrophages, osteoclasts, and microglia of the brain, all of which possess cell surface receptors for CSF-1. The protein has also been linked with male fertility and mutations in the Csf-1 gene have been found to cause osteopetrosis and failure of tooth eruption. Structurally these are short-chain 4-helical cytokines.


:

Pssm-ID: 398810  Cd Length: 140  Bit Score: 267.31  E-value: 1.17e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50054384    40 HMIGNGHLQILQQLIDSQMETACLIEYKFVDQEQLDDPVCYLKKAFVLVQVIIEETMRFKDNTPNANATERLQELSMKLN 119
Cdd:pfam05337   1 HMIGNGHLKVLQQLIDSQMETSCQIAFEFVDQEQLDDPVCYLKKAFLLVQDIMEDTMRFKDNTPNANAIVQLQELSLRLK 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 50054384   120 SCFIKDYKEQNEACVQTYKESPLRLLEKIKNFFNETKNFLEKDWNIFSKNCNDSLAKCSS 179
Cdd:pfam05337  81 SCFTKDYEEQDKACVRTFHETPLQLLEKIKNVFNETKNLLEKDWNIFSKNCNNSFAKCSS 140
PRK14959 super family cl33044
DNA polymerase III subunits gamma and tau; Provisional
 193-311 3.38e-03

DNA polymerase III subunits gamma and tau; Provisional


The actual alignment was detected with superfamily member PRK14959:

Pssm-ID: 184923 [Multi-domain]  Cd Length: 624  Bit Score: 40.43  E-value: 3.38e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50054384  193 PKATPSSDLASASPHQP--PAPSMAPLADLAWDDSQRTEGSSLLPSDLPLRIEDPGSAKQRPPRSTCQTLESTEQPNHED 270
Cdd:PRK14959 405 PQGTAPAAGMTPSSAAPatPAPSAAPSPRVPWDDAPPAPPRSGIPPRPAPRMPEASPVPGAPDSVASASDAPPTLGDPSD 484

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 50054384  271 PQPHPSAGAPIpgVEDIIESSMGTNW-------VLEEASGEASEGFLT 311
Cdd:PRK14959 485 TAEHTPSGPRT--WDGFLEFCQGRNGqggrlatVLRQATPEHADGRLR 530
 
Name Accession Description Interval E-value
CSF-1 pfam05337
Macrophage colony stimulating factor-1 (CSF-1); Colony stimulating factor 1 (CSF-1) is a ...
 40-179 1.17e-87

Macrophage colony stimulating factor-1 (CSF-1); Colony stimulating factor 1 (CSF-1) is a homodimeric polypeptide growth factor whose primary function is to regulate the survival, proliferation, differentiation, and function of cells of the mononuclear phagocytic lineage. This lineage includes mononuclear phagocytic precursors, blood monocytes, tissue macrophages, osteoclasts, and microglia of the brain, all of which possess cell surface receptors for CSF-1. The protein has also been linked with male fertility and mutations in the Csf-1 gene have been found to cause osteopetrosis and failure of tooth eruption. Structurally these are short-chain 4-helical cytokines.


Pssm-ID: 398810  Cd Length: 140  Bit Score: 267.31  E-value: 1.17e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50054384    40 HMIGNGHLQILQQLIDSQMETACLIEYKFVDQEQLDDPVCYLKKAFVLVQVIIEETMRFKDNTPNANATERLQELSMKLN 119
Cdd:pfam05337   1 HMIGNGHLKVLQQLIDSQMETSCQIAFEFVDQEQLDDPVCYLKKAFLLVQDIMEDTMRFKDNTPNANAIVQLQELSLRLK 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 50054384   120 SCFIKDYKEQNEACVQTYKESPLRLLEKIKNFFNETKNFLEKDWNIFSKNCNDSLAKCSS 179
Cdd:pfam05337  81 SCFTKDYEEQDKACVRTFHETPLQLLEKIKNVFNETKNLLEKDWNIFSKNCNNSFAKCSS 140
PRK14959 PRK14959
DNA polymerase III subunits gamma and tau; Provisional
 193-311 3.38e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184923 [Multi-domain]  Cd Length: 624  Bit Score: 40.43  E-value: 3.38e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50054384  193 PKATPSSDLASASPHQP--PAPSMAPLADLAWDDSQRTEGSSLLPSDLPLRIEDPGSAKQRPPRSTCQTLESTEQPNHED 270
Cdd:PRK14959 405 PQGTAPAAGMTPSSAAPatPAPSAAPSPRVPWDDAPPAPPRSGIPPRPAPRMPEASPVPGAPDSVASASDAPPTLGDPSD 484

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 50054384  271 PQPHPSAGAPIpgVEDIIESSMGTNW-------VLEEASGEASEGFLT 311
Cdd:PRK14959 485 TAEHTPSGPRT--WDGFLEFCQGRNGqggrlatVLRQATPEHADGRLR 530
 
Name Accession Description Interval E-value
CSF-1 pfam05337
Macrophage colony stimulating factor-1 (CSF-1); Colony stimulating factor 1 (CSF-1) is a ...
 40-179 1.17e-87

Macrophage colony stimulating factor-1 (CSF-1); Colony stimulating factor 1 (CSF-1) is a homodimeric polypeptide growth factor whose primary function is to regulate the survival, proliferation, differentiation, and function of cells of the mononuclear phagocytic lineage. This lineage includes mononuclear phagocytic precursors, blood monocytes, tissue macrophages, osteoclasts, and microglia of the brain, all of which possess cell surface receptors for CSF-1. The protein has also been linked with male fertility and mutations in the Csf-1 gene have been found to cause osteopetrosis and failure of tooth eruption. Structurally these are short-chain 4-helical cytokines.


Pssm-ID: 398810  Cd Length: 140  Bit Score: 267.31  E-value: 1.17e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50054384    40 HMIGNGHLQILQQLIDSQMETACLIEYKFVDQEQLDDPVCYLKKAFVLVQVIIEETMRFKDNTPNANATERLQELSMKLN 119
Cdd:pfam05337   1 HMIGNGHLKVLQQLIDSQMETSCQIAFEFVDQEQLDDPVCYLKKAFLLVQDIMEDTMRFKDNTPNANAIVQLQELSLRLK 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 50054384   120 SCFIKDYKEQNEACVQTYKESPLRLLEKIKNFFNETKNFLEKDWNIFSKNCNDSLAKCSS 179
Cdd:pfam05337  81 SCFTKDYEEQDKACVRTFHETPLQLLEKIKNVFNETKNLLEKDWNIFSKNCNNSFAKCSS 140
PRK14959 PRK14959
DNA polymerase III subunits gamma and tau; Provisional
 193-311 3.38e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184923 [Multi-domain]  Cd Length: 624  Bit Score: 40.43  E-value: 3.38e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50054384  193 PKATPSSDLASASPHQP--PAPSMAPLADLAWDDSQRTEGSSLLPSDLPLRIEDPGSAKQRPPRSTCQTLESTEQPNHED 270
Cdd:PRK14959 405 PQGTAPAAGMTPSSAAPatPAPSAAPSPRVPWDDAPPAPPRSGIPPRPAPRMPEASPVPGAPDSVASASDAPPTLGDPSD 484

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 50054384  271 PQPHPSAGAPIpgVEDIIESSMGTNW-------VLEEASGEASEGFLT 311
Cdd:PRK14959 485 TAEHTPSGPRT--WDGFLEFCQGRNGqggrlatVLRQATPEHADGRLR 530
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH