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Conserved domains on  [gi|1424027886|ref|NP_075566|]
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pyrroline-5-carboxylate reductase 3 isoform 1 [Homo sapiens]

Protein Classification

pyrroline-5-carboxylate reductase family protein( domain architecture ID 11417420)

pyrroline-5-carboxylate reductase family protein similar to pyrroline-5-carboxylate reductase that catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline

CATH:  1.10.3730.10|3.40.50.720
EC:  1.-.-.-
Gene Ontology:  GO:0004735|GO:0055129

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ProC COG0345
Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; ...
 7-273 3.11e-103

Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Pyrroline-5-carboxylate reductase is part of the Pathway/BioSystem: Proline biosynthesis


:

Pssm-ID: 440114 [Multi-domain]  Cd Length: 267  Bit Score: 301.21  E-value: 3.11e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1424027886   7 SPRRVGFVGAGRMAGAIAQGLIRAGkVEAQHILASAPTDRNLCHFQA-LGCRTTHSNQEVLQSCLLVIFATKPHVLPAVL 85
Cdd:COG0345     1 MSMKIGFIGAGNMGSAIIKGLLKSG-VPPEDIIVSDRSPERLEALAErYGVRVTTDNAEAAAQADVVVLAVKPQDLAEVL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1424027886  86 AEVAPVVTTEHILVSVAAGVSLSTLEELLPPNTRVLRVLPNLPCVVQEGAIVMARGRHVGSSETKLLQHLLEACGRCEEV 165
Cdd:COG0345    80 EELAPLLDPDKLVISIAAGVTLATLEEALGGGAPVVRAMPNTPALVGEGVTALAAGEAVSEEDRELVEALFSAVGKVVWV 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1424027886 166 PEAYVDIHTGLSGSGVAFVCAFSEALAEGAVKMGMPSSLAHRIAAQTLLGTAKMLLHEGQHPAQLRSDVCTPGGTTIYGL 245
Cdd:COG0345   160 DEELMDAVTALSGSGPAYVFLFIEAMADAGVALGLPRETARELAAQTVLGAAKLLLESGEHPAELRDRVTSPGGTTIAGL 239

                         250       260
                  ....*....|....*....|....*...
gi 1424027886 246 HALEQGGLRAATMSAVEAATCRAKELSR 273
Cdd:COG0345   240 KVLEEGGLRAAVIEAVEAAAERSKELGK 267
 
Name Accession Description Interval E-value
ProC COG0345
Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; ...
 7-273 3.11e-103

Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Pyrroline-5-carboxylate reductase is part of the Pathway/BioSystem: Proline biosynthesis


Pssm-ID: 440114 [Multi-domain]  Cd Length: 267  Bit Score: 301.21  E-value: 3.11e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1424027886   7 SPRRVGFVGAGRMAGAIAQGLIRAGkVEAQHILASAPTDRNLCHFQA-LGCRTTHSNQEVLQSCLLVIFATKPHVLPAVL 85
Cdd:COG0345     1 MSMKIGFIGAGNMGSAIIKGLLKSG-VPPEDIIVSDRSPERLEALAErYGVRVTTDNAEAAAQADVVVLAVKPQDLAEVL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1424027886  86 AEVAPVVTTEHILVSVAAGVSLSTLEELLPPNTRVLRVLPNLPCVVQEGAIVMARGRHVGSSETKLLQHLLEACGRCEEV 165
Cdd:COG0345    80 EELAPLLDPDKLVISIAAGVTLATLEEALGGGAPVVRAMPNTPALVGEGVTALAAGEAVSEEDRELVEALFSAVGKVVWV 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1424027886 166 PEAYVDIHTGLSGSGVAFVCAFSEALAEGAVKMGMPSSLAHRIAAQTLLGTAKMLLHEGQHPAQLRSDVCTPGGTTIYGL 245
Cdd:COG0345   160 DEELMDAVTALSGSGPAYVFLFIEAMADAGVALGLPRETARELAAQTVLGAAKLLLESGEHPAELRDRVTSPGGTTIAGL 239

                         250       260
                  ....*....|....*....|....*...
gi 1424027886 246 HALEQGGLRAATMSAVEAATCRAKELSR 273
Cdd:COG0345   240 KVLEEGGLRAAVIEAVEAAAERSKELGK 267
PLN02688 PLN02688
pyrroline-5-carboxylate reductase
 10-273 2.37e-92

pyrroline-5-carboxylate reductase


Pssm-ID: 178291 [Multi-domain]  Cd Length: 266  Bit Score: 273.76  E-value: 2.37e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1424027886  10 RVGFVGAGRMAGAIAQGLIRAGKVEAQHILASAPTDRNLC-HFQALGCRTTHSNQEVLQSCLLVIFATKPHVLPAVLAEV 88
Cdd:PLN02688    2 RVGFIGAGKMAEAIARGLVASGVVPPSRISTADDSNPARRdVFQSLGVKTAASNTEVVKSSDVIILAVKPQVVKDVLTEL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1424027886  89 APVVTTEHILVSVAAGVSLSTLEELLPPNtRVLRVLPNLPCVVQEGAIVMARGRHVGSSETKLLQHLLEACGRCEEVPEA 168
Cdd:PLN02688   82 RPLLSKDKLLVSVAAGITLADLQEWAGGR-RVVRVMPNTPCLVGEAASVMSLGPAATADDRDLVATLFGAVGKIWVVDEK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1424027886 169 YVDIHTGLSGSGVAFVCAFSEALAEGAVKMGMPSSLAHRIAAQTLLGTAKMLLHEGQHPAQLRSDVCTPGGTTIYGLHAL 248
Cdd:PLN02688  161 LLDAVTGLSGSGPAYIFLAIEALADGGVAAGLPRDVALSLAAQTVLGAAKMVLETGKHPGQLKDMVTSPGGTTIAGVHEL 240

                         250       260
                  ....*....|....*....|....*
gi 1424027886 249 EQGGLRAATMSAVEAATCRAKELSR 273
Cdd:PLN02688  241 EKGGFRAALMNAVVAAAKRSRELSK 265
proC TIGR00112
pyrroline-5-carboxylate reductase; This enzyme catalyzes the final step in proline ...
 27-270 1.02e-78

pyrroline-5-carboxylate reductase; This enzyme catalyzes the final step in proline biosynthesis. Among the four paralogs in Bacillus subtilis (proG, proH, proI, and comER), ComER is the most divergent and does not prevent proline auxotrophy from mutation of the other three. It is excluded from the seed and scores between the trusted and noise cutoffs. [Amino acid biosynthesis, Glutamate family]


Pssm-ID: 272911 [Multi-domain]  Cd Length: 245  Bit Score: 238.31  E-value: 1.02e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1424027886  27 LIRAGKVEAQHILASAP-TDRNLCHFQALGCRTTHSNQEVLQSCLLVIFATKPHVLPAVLAEVAPVVTTEHILVSVAAGV 105
Cdd:TIGR00112   1 LLKAGALAPYDIYVINRsPEKLAALAKELGIVASSDAQEAVKEADVVFLAVKPQDLEEVLSELKSEKGKDKLLISIAAGV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1424027886 106 SLSTLEELLPPNTRVLRVLPNLPCVVQEGAIVMARGRHVGSSETKLLQHLLEACGRCEEVPEAYVDIHTGLSGSGVAFVC 185
Cdd:TIGR00112  81 TLEKLSQLLGGTRRVVRVMPNTPAKVGAGVTAIAANANVSEEDRALALALFKAVGSVVELPEALMDAVTALSGSGPAYVF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1424027886 186 AFSEALAEGAVKMGMPSSLAHRIAAQTLLGTAKMLLHEGQHPAQLRSDVCTPGGTTIYGLHALEQGGLRAATMSAVEAAT 265
Cdd:TIGR00112 161 LFIEALADAGVKQGLPRELALELAAQTVKGAAKLLEESGEHPALLKDQVTSPGGTTIAGLAVLEEKGVRGAVIEAIEAAV 240


                  ....*
gi 1424027886 266 CRAKE 270
Cdd:TIGR00112 241 RRSRE 245
P5CR_dimer pfam14748
Pyrroline-5-carboxylate reductase dimerization; Pyrroline-5-carboxylate reductase consists of ...
 167-270 1.95e-44

Pyrroline-5-carboxylate reductase dimerization; Pyrroline-5-carboxylate reductase consists of two domains, an N-terminal catalytic domain (pfam03807) and a C-terminal dimerization domain. This is the dimerization domain.


Pssm-ID: 464294 [Multi-domain]  Cd Length: 104  Bit Score: 145.62  E-value: 1.95e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1424027886 167 EAYVDIHTGLSGSGVAFVCAFSEALAEGAVKMGMPSSLAHRIAAQTLLGTAKMLLHEGQHPAQLRSDVCTPGGTTIYGLH 246
Cdd:pfam14748   1 ESLMDAVTALSGSGPAYVFLFIEALADAGVAMGLPREEARELAAQTVLGAAKLLLTSGEHPAELRDKVTSPGGTTIAGLA 80

                          90       100
                  ....*....|....*....|....
gi 1424027886 247 ALEQGGLRAATMSAVEAATCRAKE 270
Cdd:pfam14748  81 VLEEGGFRGAVIEAVEAATKRAKE 104
 
Name Accession Description Interval E-value
ProC COG0345
Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; ...
 7-273 3.11e-103

Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Pyrroline-5-carboxylate reductase is part of the Pathway/BioSystem: Proline biosynthesis


Pssm-ID: 440114 [Multi-domain]  Cd Length: 267  Bit Score: 301.21  E-value: 3.11e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1424027886   7 SPRRVGFVGAGRMAGAIAQGLIRAGkVEAQHILASAPTDRNLCHFQA-LGCRTTHSNQEVLQSCLLVIFATKPHVLPAVL 85
Cdd:COG0345     1 MSMKIGFIGAGNMGSAIIKGLLKSG-VPPEDIIVSDRSPERLEALAErYGVRVTTDNAEAAAQADVVVLAVKPQDLAEVL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1424027886  86 AEVAPVVTTEHILVSVAAGVSLSTLEELLPPNTRVLRVLPNLPCVVQEGAIVMARGRHVGSSETKLLQHLLEACGRCEEV 165
Cdd:COG0345    80 EELAPLLDPDKLVISIAAGVTLATLEEALGGGAPVVRAMPNTPALVGEGVTALAAGEAVSEEDRELVEALFSAVGKVVWV 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1424027886 166 PEAYVDIHTGLSGSGVAFVCAFSEALAEGAVKMGMPSSLAHRIAAQTLLGTAKMLLHEGQHPAQLRSDVCTPGGTTIYGL 245
Cdd:COG0345   160 DEELMDAVTALSGSGPAYVFLFIEAMADAGVALGLPRETARELAAQTVLGAAKLLLESGEHPAELRDRVTSPGGTTIAGL 239

                         250       260
                  ....*....|....*....|....*...
gi 1424027886 246 HALEQGGLRAATMSAVEAATCRAKELSR 273
Cdd:COG0345   240 KVLEEGGLRAAVIEAVEAAAERSKELGK 267
PLN02688 PLN02688
pyrroline-5-carboxylate reductase
 10-273 2.37e-92

pyrroline-5-carboxylate reductase


Pssm-ID: 178291 [Multi-domain]  Cd Length: 266  Bit Score: 273.76  E-value: 2.37e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1424027886  10 RVGFVGAGRMAGAIAQGLIRAGKVEAQHILASAPTDRNLC-HFQALGCRTTHSNQEVLQSCLLVIFATKPHVLPAVLAEV 88
Cdd:PLN02688    2 RVGFIGAGKMAEAIARGLVASGVVPPSRISTADDSNPARRdVFQSLGVKTAASNTEVVKSSDVIILAVKPQVVKDVLTEL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1424027886  89 APVVTTEHILVSVAAGVSLSTLEELLPPNtRVLRVLPNLPCVVQEGAIVMARGRHVGSSETKLLQHLLEACGRCEEVPEA 168
Cdd:PLN02688   82 RPLLSKDKLLVSVAAGITLADLQEWAGGR-RVVRVMPNTPCLVGEAASVMSLGPAATADDRDLVATLFGAVGKIWVVDEK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1424027886 169 YVDIHTGLSGSGVAFVCAFSEALAEGAVKMGMPSSLAHRIAAQTLLGTAKMLLHEGQHPAQLRSDVCTPGGTTIYGLHAL 248
Cdd:PLN02688  161 LLDAVTGLSGSGPAYIFLAIEALADGGVAAGLPRDVALSLAAQTVLGAAKMVLETGKHPGQLKDMVTSPGGTTIAGVHEL 240

                         250       260
                  ....*....|....*....|....*
gi 1424027886 249 EQGGLRAATMSAVEAATCRAKELSR 273
Cdd:PLN02688  241 EKGGFRAALMNAVVAAAKRSRELSK 265
PRK11880 PRK11880
pyrroline-5-carboxylate reductase; Reviewed
 9-274 2.64e-85

pyrroline-5-carboxylate reductase; Reviewed


Pssm-ID: 237008 [Multi-domain]  Cd Length: 267  Bit Score: 255.84  E-value: 2.64e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1424027886   9 RRVGFVGAGRMAGAIAQGLIRAGkVEAQHILASAPTDRNLCHF-QALGCRTTHSNQEVLQSCLLVIFATKPHVLPAVLAE 87
Cdd:PRK11880    3 KKIGFIGGGNMASAIIGGLLASG-VPAKDIIVSDPSPEKRAALaEEYGVRAATDNQEAAQEADVVVLAVKPQVMEEVLSE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1424027886  88 VAPVVTTehILVSVAAGVSLSTLEELLPPNTRVLRVLPNLPCVVQEGAIVMARGRHVGSSETKLLQHLLEACGRCEEVP- 166
Cdd:PRK11880   82 LKGQLDK--LVVSIAAGVTLARLERLLGADLPVVRAMPNTPALVGAGMTALTANALVSAEDRELVENLLSAFGKVVWVDd 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1424027886 167 EAYVDIHTGLSGSGVAFVCAFSEALAEGAVKMGMPSSLAHRIAAQTLLGTAKMLLHEGQHPAQLRSDVCTPGGTTIYGLH 246
Cdd:PRK11880  160 EKQMDAVTAVSGSGPAYVFLFIEALADAGVKLGLPREQARKLAAQTVLGAAKLLLESGEHPAELRDNVTSPGGTTIAALR 239

                         250       260
                  ....*....|....*....|....*...
gi 1424027886 247 ALEQGGLRAATMSAVEAATCRAKELSRK 274
Cdd:PRK11880  240 VLEEKGLRAAVIEAVQAAAKRSKELGKE 267
proC TIGR00112
pyrroline-5-carboxylate reductase; This enzyme catalyzes the final step in proline ...
 27-270 1.02e-78

pyrroline-5-carboxylate reductase; This enzyme catalyzes the final step in proline biosynthesis. Among the four paralogs in Bacillus subtilis (proG, proH, proI, and comER), ComER is the most divergent and does not prevent proline auxotrophy from mutation of the other three. It is excluded from the seed and scores between the trusted and noise cutoffs. [Amino acid biosynthesis, Glutamate family]


Pssm-ID: 272911 [Multi-domain]  Cd Length: 245  Bit Score: 238.31  E-value: 1.02e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1424027886  27 LIRAGKVEAQHILASAP-TDRNLCHFQALGCRTTHSNQEVLQSCLLVIFATKPHVLPAVLAEVAPVVTTEHILVSVAAGV 105
Cdd:TIGR00112   1 LLKAGALAPYDIYVINRsPEKLAALAKELGIVASSDAQEAVKEADVVFLAVKPQDLEEVLSELKSEKGKDKLLISIAAGV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1424027886 106 SLSTLEELLPPNTRVLRVLPNLPCVVQEGAIVMARGRHVGSSETKLLQHLLEACGRCEEVPEAYVDIHTGLSGSGVAFVC 185
Cdd:TIGR00112  81 TLEKLSQLLGGTRRVVRVMPNTPAKVGAGVTAIAANANVSEEDRALALALFKAVGSVVELPEALMDAVTALSGSGPAYVF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1424027886 186 AFSEALAEGAVKMGMPSSLAHRIAAQTLLGTAKMLLHEGQHPAQLRSDVCTPGGTTIYGLHALEQGGLRAATMSAVEAAT 265
Cdd:TIGR00112 161 LFIEALADAGVKQGLPRELALELAAQTVKGAAKLLEESGEHPALLKDQVTSPGGTTIAGLAVLEEKGVRGAVIEAIEAAV 240


                  ....*
gi 1424027886 266 CRAKE 270
Cdd:TIGR00112 241 RRSRE 245
PTZ00431 PTZ00431
pyrroline carboxylate reductase; Provisional
 10-271 9.76e-59

pyrroline carboxylate reductase; Provisional


Pssm-ID: 173621 [Multi-domain]  Cd Length: 260  Bit Score: 187.85  E-value: 9.76e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1424027886  10 RVGFVGAGRMAGAIAQGLIRAGKVEAQHILASAPTDRN--LCHFQalgcrtthSNQEVLQSCLLVIFATKPHVLPAVLAE 87
Cdd:PTZ00431    5 RVGFIGLGKMGSALAYGIENSNIIGKENIYYHTPSKKNtpFVYLQ--------SNEELAKTCDIIVLAVKPDLAGKVLLE 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1424027886  88 VAPVVTTEhILVSVAAGVSLSTLEELLPPNTRVLRVLPNLPCVVQEGAIVMARGRHVGSSETKLLQHLLEACGRCEEVPE 167
Cdd:PTZ00431   77 IKPYLGSK-LLISICGGLNLKTLEEMVGVEAKIVRVMPNTPSLVGQGSLVFCANNNVDSTDKKKVIDIFSACGIIQEIKE 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1424027886 168 AYVDIHTGLSGSGVAFVCAFSEALAEGAVKMGMPSSLAHRIAAQTLLGTAKMLLHEGQHPAQLRSDVCTPGGTTIYGLHA 247
Cdd:PTZ00431  156 KDMDIATAISGCGPAYVFLFIESLIDAGVKNGLNRDVSKNLVLQTILGSVHMVKASDQPVQQLKDDVCSPGGITIVGLYT 235

                         250       260
                  ....*....|....*....|....
gi 1424027886 248 LEQGGLRAATMSAVEAATCRAKEL 271
Cdd:PTZ00431  236 LEKHAFKYTVMDAVESACQKSKSM 259
PRK07679 PRK07679
pyrroline-5-carboxylate reductase; Reviewed
 7-271 3.86e-45

pyrroline-5-carboxylate reductase; Reviewed


Pssm-ID: 181079 [Multi-domain]  Cd Length: 279  Bit Score: 153.39  E-value: 3.86e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1424027886   7 SPRRVGFVGAGRMAGAIAQGLIRAGKVEAQHILASAPTDRNLCHF--QALGCRTTHSNQEVLQSCLLVIFATKPHVLPAV 84
Cdd:PRK07679    2 SIQNISFLGAGSIAEAIIGGLLHANVVKGEQITVSNRSNETRLQElhQKYGVKGTHNKKELLTDANILFLAMKPKDVAEA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1424027886  85 LAEVAPVVTTEHILVSVAAGVSLSTLEELLPPNTRVLRVLPNLPCVVQEGAIVMARGRHVGSSETKLLQHLLEACGRCEE 164
Cdd:PRK07679   82 LIPFKEYIHNNQLIISLLAGVSTHSIRNLLQKDVPIIRAMPNTSAAILKSATAISPSKHATAEHIQTAKALFETIGLVSV 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1424027886 165 VPEAYVDIHTGLSGSGVAFVCAFSEALAEGAVKMGMPSSLAHRIAAQTLLGTAKMLLHEGQHPAQLRSDVCTPGGTTIYG 244
Cdd:PRK07679  162 VEEEDMHAVTALSGSGPAYIYYVVEAMEKAAKKIGLKEDVAKSLILQTMIGAAEMLKASEKHPSILRKEITSPGGTTEAG 241

                         250       260
                  ....*....|....*....|....*..
gi 1424027886 245 LHALEQGGLRAATMSAVEAATCRAKEL 271
Cdd:PRK07679  242 IEVLQEHRFQQALISCITQATQRSHNL 268
P5CR_dimer pfam14748
Pyrroline-5-carboxylate reductase dimerization; Pyrroline-5-carboxylate reductase consists of ...
 167-270 1.95e-44

Pyrroline-5-carboxylate reductase dimerization; Pyrroline-5-carboxylate reductase consists of two domains, an N-terminal catalytic domain (pfam03807) and a C-terminal dimerization domain. This is the dimerization domain.


Pssm-ID: 464294 [Multi-domain]  Cd Length: 104  Bit Score: 145.62  E-value: 1.95e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1424027886 167 EAYVDIHTGLSGSGVAFVCAFSEALAEGAVKMGMPSSLAHRIAAQTLLGTAKMLLHEGQHPAQLRSDVCTPGGTTIYGLH 246
Cdd:pfam14748   1 ESLMDAVTALSGSGPAYVFLFIEALADAGVAMGLPREEARELAAQTVLGAAKLLLTSGEHPAELRDKVTSPGGTTIAGLA 80

                          90       100
                  ....*....|....*....|....
gi 1424027886 247 ALEQGGLRAATMSAVEAATCRAKE 270
Cdd:pfam14748  81 VLEEGGFRGAVIEAVEAATKRAKE 104
PRK06928 PRK06928
pyrroline-5-carboxylate reductase; Reviewed
 10-244 5.03e-28

pyrroline-5-carboxylate reductase; Reviewed


Pssm-ID: 235888 [Multi-domain]  Cd Length: 277  Bit Score: 108.70  E-value: 5.03e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1424027886  10 RVGFVGAGRMAGAIAQGLIRAGKVEAQHILASapTDRNLCHFQALGCRTTH-----SNQEVLQSCLLvIFATKP--HVLP 82
Cdd:PRK06928    3 KIGFIGYGSMADMIATKLLETEVATPEEIILY--SSSKNEHFNQLYDKYPTveladNEAEIFTKCDH-SFICVPplAVLP 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1424027886  83 aVLAEVAPVVTTEHILVSVAAGVSLSTLEELlPPNTRVLRVLPNLPCVVQEGAIVMARGRHVGSSETKLLQHLLEACGRC 162
Cdd:PRK06928   80 -LLKDCAPVLTPDRHVVSIAAGVSLDDLLEI-TPGLQVSRLIPSLTSAVGVGTSLVAHAETVNEANKSRLEETLSHFSHV 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1424027886 163 EEVPEAYVDIHTGLSGSGVAFVCAFSEALAEGAVKMgmpSSLAHRIAAQ----TLLGTAKMLLHEGQHPAQLRSDVCTPG 238
Cdd:PRK06928  158 MTIREENMDIASNLTSSSPGFIAAIFEEFAEAAVRN---SSLSDEEAFQflnfALAGTGKLLVEEDYTFSGTIERVATKG 234


                  ....*.
gi 1424027886 239 GTTIYG 244
Cdd:PRK06928  235 GITAEG 240
PRK07680 PRK07680
late competence protein ComER; Validated
 10-251 3.17e-24

late competence protein ComER; Validated


Pssm-ID: 181080 [Multi-domain]  Cd Length: 273  Bit Score: 98.12  E-value: 3.17e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1424027886  10 RVGFVGAGRMAGAIAQGLIRAGKVEAQHILAsapTDRNLCHFQAL-----GCRTTHSNQEVLQSCLLVIFATKPHVLPAV 84
Cdd:PRK07680    2 NIGFIGTGNMGTILIEAFLESGAVKPSQLTI---TNRTPAKAYHIkerypGIHVAKTIEEVISQSDLIFICVKPLDIYPL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1424027886  85 LAEVAPVVTTEHILVSVAAGVSLSTLEELLPpnTRVLRVLPNLPCVVQEGAIVMARGRHVGSSETKLLQHLLEACGRCEE 164
Cdd:PRK07680   79 LQKLAPHLTDEHCLVSITSPISVEQLETLVP--CQVARIIPSITNRALSGASLFTFGSRCSEEDQQKLERLFSNISTPLV 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1424027886 165 VPEAYVDIHTGLSGSGVAFVCAFSEALAEGAVKM-GMPSSLAHRIAAQTLLGTAKMLLHEGQHPAQLRSDVCTPGGTTIY 243
Cdd:PRK07680  157 IEEDITRVSSDIVSCGPAFFSYLLQRFIDAAVEEtNISKEEATTLASEMLIGMGKLLEKGLYTLPTLQEKVCVKGGITGE 236


                  ....*...
gi 1424027886 244 GLHALEQG 251
Cdd:PRK07680  237 GIKVLEEE 244
F420_oxidored pfam03807
NADP oxidoreductase coenzyme F420-dependent;
12-104 3.51e-11

NADP oxidoreductase coenzyme F420-dependent;


Pssm-ID: 397743 [Multi-domain]  Cd Length: 92  Bit Score: 58.40  E-value: 3.51e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1424027886  12 GFVGAGRMAGAIAQGLIRAGKVEAqhILASAPTDRNLCHF-QALGCRTTH-SNQEVLQSCLLVIFATKPHVLPAVLAEVA 89
Cdd:pfam03807   1 GFIGAGNMGEALARGLVAAGPHEV--VVANSRNPEKAEELaEEYGVGATAvDNEEAAEEADVVFLAVKPEDAPDVLSELS 78

                          90
                  ....*....|....*
gi 1424027886  90 PVVtTEHILVSVAAG 104
Cdd:pfam03807  79 DLL-KGKIVISIAAG 92
PRK06476 PRK06476
pyrroline-5-carboxylate reductase; Reviewed
 10-263 2.41e-08

pyrroline-5-carboxylate reductase; Reviewed


Pssm-ID: 235812 [Multi-domain]  Cd Length: 258  Bit Score: 53.48  E-value: 2.41e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1424027886  10 RVGFVGAGRMAGAIAQGLIRAGkVEAQHILAS---APTDRNLCH-FQALgcRTTHSNQEVLQSCLLVIFAtkphVLPAVL 85
Cdd:PRK06476    2 KIGFIGTGAITEAMVTGLLTSP-ADVSEIIVSprnAQIAARLAErFPKV--RIAKDNQAVVDRSDVVFLA----VRPQIA 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1424027886  86 AEVAPVVT--TEHILVSVAAGVSLSTLEELLPPNTRVLRVLPnLPCVVQ-EG--AIVMArgrhvgsseTKLLQHLLEACG 160
Cdd:PRK06476   75 EEVLRALRfrPGQTVISVIAATDRAALLEWIGHDVKLVRAIP-LPFVAErKGvtAIYPP---------DPFVAALFDALG 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1424027886 161 RCEEV--PEAYVDIHTGLSGSGVAFvcAFSEALAEGAVKMGMPSSLAHRIAAQTLLGTAKMLLHEGQHP-AQLRSDVCTP 237
Cdd:PRK06476  145 TAVECdsEEEYDLLAAASALMATYF--GILETATGWLEEQGLKRQKARAYLAPLFASLAQDAVRSTKTDfSALSREFSTK 222

                         250       260
                  ....*....|....*....|....*.
gi 1424027886 238 GGTTIYGLHALEQGGLRAATMSAVEA 263
Cdd:PRK06476  223 GGLNEQVLNDFSRQGGYAALTDALDR 248
GpsA COG0240
Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Glycerol-3-phosphate ...
 10-120 4.81e-04

Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Glycerol-3-phosphate dehydrogenase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 440010 [Multi-domain]  Cd Length: 327  Bit Score: 40.79  E-value: 4.81e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1424027886  10 RVGFVGAGRMAGAIAQGLIRAG---------KVEAQHI---------LASAPTDRNLchfqalgcRTTHSNQEVLQSCLL 71
Cdd:COG0240     2 KIAVLGAGSWGTALAKVLARNGhevtlwgrdPEVAEEInetrenpryLPGVKLPENL--------RATSDLEEALAGADL 73

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1424027886  72 VIFATKPHVLPAVLAEVAPVVTTEHILVSVAAGVSLST-------LEELLPPNTRV 120
Cdd:COG0240    74 VLLAVPSQALREVLEQLAPLLPPGAPVVSATKGIEPGTgllmsevIAEELPGALRI 129
COG5495 COG5495
Predicted oxidoreductase, contains short-chain dehydrogenase (SDR) and DUF2520 domains ...
 10-111 1.17e-03

Predicted oxidoreductase, contains short-chain dehydrogenase (SDR) and DUF2520 domains [General function prediction only];


Pssm-ID: 444246 [Multi-domain]  Cd Length: 286  Bit Score: 39.80  E-value: 1.17e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1424027886  10 RVGFVGAGRMAGAIAQGLIRAGKVEAQhilASAPTDRNLCHFQA-LGCRTTHSNQEVLQSCLLVIFATKPHVLPAVLAEV 88
Cdd:COG5495     5 KIGIIGAGRVGTALAAALRAAGHEVVG---VYSRSPASAERAAAlLGAVPALDLEELAAEADLVLLAVPDDAIAEVAAGL 81

                          90       100
                  ....*....|....*....|....*
gi 1424027886  89 A--PVVTTEHILVSVAAGVSLSTLE 111
Cdd:COG5495    82 AaaGALRPGQLVVHTSGALGSDVLA 106
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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