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Conserved domains on  [gi|11967935|ref|NP_071856|]
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solute carrier family 13 member 2 [Mus musculus]

Protein Classification

transporter permease( domain architecture ID 229430)

transporter permease similar to ArsB/NhaD family permeases, which typically contain 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ArsB_NhaD_permease super family cl21473
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, ...
 6-560 4.22e-113

Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump.


The actual alignment was detected with superfamily member pfam00939:

Pssm-ID: 473875 [Multi-domain]  Cd Length: 472  Bit Score: 345.51  E-value: 4.22e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11967935     6 QALWAYRSYLIVLCLPIFLLPLPLIVQTKEAYCAYSIILMALLWCTEALPLAVTALFPIILFPLMGIMEASK----VCLE 81
Cdd:pfam00939   1 LTLWWKLLALLAVLLIILLLPAPDGLPSKAWHLFAIFIATIVGWILEPLPMAVIALFAISLSAILIGTLLAKalswALSG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11967935    82 YFKDTNILFVGGLMVAIAVEHWNLHKRIALGVLLIIGVRPalLLLGFMLVTAFLSMWISNTATTAMMLPIGYAVLEQLQG 161
Cdd:pfam00939  81 FSSTTTWLVFGAFFISAAFEKTGLGRRIALVLVKKMGKRT--LGLGYGLVFSDLLLAPATPSNTARAGGIVFPIIMSLPP 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11967935   162 SqkdveegnSNPSFELQEAspqkeetkldngqavsvssepraqktkehHRFSQGLSLCICYSASIGGIATLTGTTPNLVL 241
Cdd:pfam00939 159 A--------FGSDPEKGSE-----------------------------RRIGAYLMWTVYQSTSITSAMFLTAMAPNLLL 201

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11967935   242 QGQVNSIfpeNSNVVNFASWFGFAFPTMVILLLLAWLWLQVLFLGVNFRKNfgfgegeeerkqAAFQVIKTQHRLLGPMS 321
Cdd:pfam00939 202 LGLMNSI---LGVTITWASWFLAAIPPGVILLLLAPLLLYVLYPPEIKSVP------------DAKAIAKTELKELGPMT 266

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11967935   322 FAEKAVTFLFVLLVVLWFTREpgfFPGwgdtafankkgqsmVSDGTVAIFISLIMFIIPskipgltedpkkpgklkappa 401
Cdd:pfam00939 267 FREKALLGLFVLLLLLWIFGG---SLN--------------IDATTVAIIGLALMLLLR--------------------- 308

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11967935   402 ILTWK-TVNDKMPWNILILLGGGFALAKGSEESGLSKWLGDKLTPLQ--HVPPSATVLILSLLVAIFTECTSNVATTTLF 478
Cdd:pfam00939 309 ILDWKdIVKNKGAWNTLIWLGGLIMLANGLERSGFIEWLGNTLSTSLsgFSPAMAFIIILSLFYLSHYLFASATAHTAAM 388

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11967935   479 LPILASMAQAICLHP-LYVMLPCTLAASLA-FMLPVATPPNAIVFSFGGLKVSDMARAGFLLNIIGVLTITLSINSWSIP 556
Cdd:pfam00939 389 LPIFAAVAQAIPGAPpLLAALLLGFAISLGgFLTPYGTGPGPIYFGSGYLKVKDWWRIGAILTIIGLLILLLLGNWWWKP 468


                  ....
gi 11967935   557 IFKL 560
Cdd:pfam00939 469 LGSL 472
 
Name Accession Description Interval E-value
Na_sulph_symp pfam00939
Sodium:sulfate symporter transmembrane region; There are also some members in this family that ...
 6-560 4.22e-113

Sodium:sulfate symporter transmembrane region; There are also some members in this family that do not match the Prosite motif, and belong to the subfamily SODIT1.


Pssm-ID: 279307 [Multi-domain]  Cd Length: 472  Bit Score: 345.51  E-value: 4.22e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11967935     6 QALWAYRSYLIVLCLPIFLLPLPLIVQTKEAYCAYSIILMALLWCTEALPLAVTALFPIILFPLMGIMEASK----VCLE 81
Cdd:pfam00939   1 LTLWWKLLALLAVLLIILLLPAPDGLPSKAWHLFAIFIATIVGWILEPLPMAVIALFAISLSAILIGTLLAKalswALSG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11967935    82 YFKDTNILFVGGLMVAIAVEHWNLHKRIALGVLLIIGVRPalLLLGFMLVTAFLSMWISNTATTAMMLPIGYAVLEQLQG 161
Cdd:pfam00939  81 FSSTTTWLVFGAFFISAAFEKTGLGRRIALVLVKKMGKRT--LGLGYGLVFSDLLLAPATPSNTARAGGIVFPIIMSLPP 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11967935   162 SqkdveegnSNPSFELQEAspqkeetkldngqavsvssepraqktkehHRFSQGLSLCICYSASIGGIATLTGTTPNLVL 241
Cdd:pfam00939 159 A--------FGSDPEKGSE-----------------------------RRIGAYLMWTVYQSTSITSAMFLTAMAPNLLL 201

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11967935   242 QGQVNSIfpeNSNVVNFASWFGFAFPTMVILLLLAWLWLQVLFLGVNFRKNfgfgegeeerkqAAFQVIKTQHRLLGPMS 321
Cdd:pfam00939 202 LGLMNSI---LGVTITWASWFLAAIPPGVILLLLAPLLLYVLYPPEIKSVP------------DAKAIAKTELKELGPMT 266

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11967935   322 FAEKAVTFLFVLLVVLWFTREpgfFPGwgdtafankkgqsmVSDGTVAIFISLIMFIIPskipgltedpkkpgklkappa 401
Cdd:pfam00939 267 FREKALLGLFVLLLLLWIFGG---SLN--------------IDATTVAIIGLALMLLLR--------------------- 308

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11967935   402 ILTWK-TVNDKMPWNILILLGGGFALAKGSEESGLSKWLGDKLTPLQ--HVPPSATVLILSLLVAIFTECTSNVATTTLF 478
Cdd:pfam00939 309 ILDWKdIVKNKGAWNTLIWLGGLIMLANGLERSGFIEWLGNTLSTSLsgFSPAMAFIIILSLFYLSHYLFASATAHTAAM 388

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11967935   479 LPILASMAQAICLHP-LYVMLPCTLAASLA-FMLPVATPPNAIVFSFGGLKVSDMARAGFLLNIIGVLTITLSINSWSIP 556
Cdd:pfam00939 389 LPIFAAVAQAIPGAPpLLAALLLGFAISLGgFLTPYGTGPGPIYFGSGYLKVKDWWRIGAILTIIGLLILLLLGNWWWKP 468


                  ....
gi 11967935   557 IFKL 560
Cdd:pfam00939 469 LGSL 472
CitT COG0471
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
91-553 5.86e-89

Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];


Pssm-ID: 440239 [Multi-domain]  Cd Length: 369  Bit Score: 279.35  E-value: 5.86e-89
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11967935  91 VGGLMVAIAVEHWNLHKRIALGVLLIIGVRPALLLLGFMLVTAFLSMWISNTATTAMMLPIGYAVLEQLqgsqkdveegn 170
Cdd:COG0471   1 LGGFVLAAALEKTGLGRRIALLLLKRFGGSPLRLLLGLMLATALLSAFISNTARAAMMLPIALSIAAAL----------- 69

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11967935 171 snpsfelqeaspqkeetkldngqavsvssepraqKTKEHHRFSQGLSLCICYSASIGGIATLTGTTPNLVLQGQVNSIFP 250
Cdd:COG0471  70 ----------------------------------GSEKRSKFGSALLLPIAFAASIGGMGTLIGTPPNLIAAGLLEEATG 115

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11967935 251 ENsnvVNFASWFGFAFPTMVILLLLAwlwlqVLFLGVNFRKnfgfgegEEERKQAAFQVIKTQHRLLGPMSFAEKAVTFL 330
Cdd:COG0471 116 IP---ISFFEWMLVGLPVALVGLLLL-----WLVLYRLLPP-------EIKEVPGSKEVIREELAELGPLSRREKIALAI 180

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11967935 331 FVLLVVLWFTRepgffpgwgdtafankkGQSMVSDGTVAIFISLIMFIipskipgltedpkkpgklkapPAILTWKTVND 410
Cdd:COG0471 181 FALTVLLWITG-----------------SLHGIPIAVVALLGAVLLLL---------------------TGVLTWKDAYK 222

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11967935 411 KMPWNILILLGGGFALAKGSEESGLSKWLGDKLTP-LQHVPPSATVLILSLLVAIFTECTSNVATTTLFLPILASMAQAI 489
Cdd:COG0471 223 SIPWGVLLLFGGGLALGAALEKTGLAAWLADALLPlLGGLSPLLLLLLLALLTLLLTEFASNTATAALLLPIAISLAQAL 302

                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 11967935 490 CLHPLYVMLPCTLAASLAFMLPVATPPNAIVFSFGGLKVSDMARAGFLLNIIGVLTITLSINSW 553
Cdd:COG0471 303 GVNPLPLALAVAFAASCAFLLPVGTPPNAIVYGSGYYKFKDFLKVGLPLNLIGLVVLLLLGPLW 366
SLC13_permease cd01115
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ...
 42-553 4.90e-87

Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.


Pssm-ID: 238535 [Multi-domain]  Cd Length: 382  Bit Score: 274.85  E-value: 4.90e-87
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11967935  42 IILMALLWCTEALPLAVTALFPIILFPLMGIMEASKVCLEYFKDTNILFVGGLMVAIAVEHWNLHKRIALGVLLIIGVRP 121
Cdd:cd01115   4 LVFAAVLFVTEALPLDVTALLVPVLLVLLGVVPPKEAFSGFSDPAVILFLAGFILGAALTRTGLAKRIATKLLKRAGKGE 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11967935 122 ALLLLGFMLVTAFLSMWISNTATTAMMLPIGYAVLEQLQGSqkdveegnsnpsfelqeaspqkeetkldngqavsvssep 201
Cdd:cd01115  84 RRLLLLLMLVTAFLSAFMSNTATVAIMLPVALGLAAKLDIS--------------------------------------- 124

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11967935 202 raqktkehhrfSQGLSLCICYSASIGGIATLTGTTPNLVLQGQVNSIFPENsnvVNFASWFGFAFPTMVIllllawlwlq 281
Cdd:cd01115 125 -----------PSRLLMPLAFAASIGGMLTLIGTPPNLVASGYLESLGGQG---FSFFEFTPIGLPLLII---------- 180

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11967935 282 vlflgvnfrknfgfgegeeerkqaafqviktqhrllgpmsfaekavtflfVLLVVLWFTREPGFFPGWGDTAFAN-KKGQ 360
Cdd:cd01115 181 --------------------------------------------------GLLYLWFIFRLAVLIITIVLLAALAaITGL 210

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11967935 361 SMVSDGTVAIFISLIMFiipskipgltedpkkpgklkappAILTWKTVNDKMPWNILILLGGGFALAKGSEESGLSKWLG 440
Cdd:cd01115 211 LPVSVAIAIGAIVLVFG-----------------------GVLLTKEDYKSIDWGIIFLFAGGIPLGKALESSGAAALIA 267

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11967935 441 DKLTP-LQHVPPSATVLILSLLVAIFTECTSNVATTTLFLPILASMAQAICLHPLYVMLPCTLAASLAFMLPVATPPNAI 519
Cdd:cd01115 268 EALISlLGGLPPFAILLLLCLLTLVLTNFISNTATAVLLAPIALSIALSLGLPPEALLLAVAIGASCAFMLPVGTPPNAI 347

                       490       500       510
                ....*....|....*....|....*....|....
gi 11967935 520 VFSFGGLKVSDMARAGFLLNIIGVLTITLSINSW 553
Cdd:cd01115 348 VLGPGGYKFSDFAKVGLPLSILSLVVSVTMIPLI 381
dass TIGR00785
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally ...
 43-553 3.67e-57

anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273267 [Multi-domain]  Cd Length: 444  Bit Score: 198.34  E-value: 3.67e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11967935    43 ILMALLWCTEALPLAVTALFPI-ILFPLMGIMEASKV--CLEYFKDTNI-LFVGGLMVAIAVEHWNLHKRIALGVLLIIG 118
Cdd:TIGR00785  18 VAAIVGWILEPLPLPVTALLAIpIIAVLLGVLSAFKFknALSGFADPTIwLFFGAFILATALVKTGLGKRIAYKLVGKMG 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11967935   119 VRPALL-LLGFMLVTAFLSMWISNTA-TTAMMLPIGYAVLEQLqGSQKDveegnsnpsfelqeaspqkeetkldngqavs 196
Cdd:TIGR00785  98 GTTLGLgYFLVFLETLLAPMWPSNTArAGGILLPIIKSLLPLL-GSKPE------------------------------- 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11967935   197 vssepraqktKEHHRFSQGLSLCICYSASIGGIATLTGTTPNLVLQGQVNSIFpenSNVVNFASWFGFAFPTMVILLLLA 276
Cdd:TIGR00785 146 ----------KSPRKIGKYLMLGIAYSASIGSSGFLTGSAPNALAAGILSKIL---GIQISWGDWFLAGLPLGIILLLLV 212

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11967935   277 WLWLQVLFlgvnfrknfgfgEGEEERKQAAFQVIKTQHRLLGPMSFAEKAVTFLFVLLVVLWFtrepgffpgwgdtaFAN 356
Cdd:TIGR00785 213 PLLLYVLF------------PPELKLKDEVDLWAKEELEEMGPMSFREKALLGIFLLALLLWI--------------FGG 266

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11967935   357 KKGqsmVSDGTVAIFISLIMFIIpskipgltedpkkpgklkappAILTWKTVN-DKMPWNILILLGGGFALAKGSEESGL 435
Cdd:TIGR00785 267 SLG---INASVVALLAVVLMLFL---------------------GIVTWKDIQkNKVAWNTLILFGGLIGLAGGLKKSGF 322

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11967935   436 SKWLGDKL-TPLQHVPPSATVLILSLLVAIF-TECTSNVATTTLFLPILASMAQAICLHPLYVMLPCTLAASLA-FMLPV 512
Cdd:TIGR00785 323 IKWFSEKLvGILDGLSPTIAVLVLVVLFYIIlYFFASNTAHTAALVPIFFSVASAQGIPLELLALALALSASLMgFLTPY 402

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|.
gi 11967935   513 ATPPNAIVFSFGGLKVSDMARAGFLLNIIGVLTITLSINSW 553
Cdd:TIGR00785 403 ATPPNAIAYGSGYVKIKDMWRVGAIIGIVGLIVLLLVGTLW 443
 
Name Accession Description Interval E-value
Na_sulph_symp pfam00939
Sodium:sulfate symporter transmembrane region; There are also some members in this family that ...
 6-560 4.22e-113

Sodium:sulfate symporter transmembrane region; There are also some members in this family that do not match the Prosite motif, and belong to the subfamily SODIT1.


Pssm-ID: 279307 [Multi-domain]  Cd Length: 472  Bit Score: 345.51  E-value: 4.22e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11967935     6 QALWAYRSYLIVLCLPIFLLPLPLIVQTKEAYCAYSIILMALLWCTEALPLAVTALFPIILFPLMGIMEASK----VCLE 81
Cdd:pfam00939   1 LTLWWKLLALLAVLLIILLLPAPDGLPSKAWHLFAIFIATIVGWILEPLPMAVIALFAISLSAILIGTLLAKalswALSG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11967935    82 YFKDTNILFVGGLMVAIAVEHWNLHKRIALGVLLIIGVRPalLLLGFMLVTAFLSMWISNTATTAMMLPIGYAVLEQLQG 161
Cdd:pfam00939  81 FSSTTTWLVFGAFFISAAFEKTGLGRRIALVLVKKMGKRT--LGLGYGLVFSDLLLAPATPSNTARAGGIVFPIIMSLPP 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11967935   162 SqkdveegnSNPSFELQEAspqkeetkldngqavsvssepraqktkehHRFSQGLSLCICYSASIGGIATLTGTTPNLVL 241
Cdd:pfam00939 159 A--------FGSDPEKGSE-----------------------------RRIGAYLMWTVYQSTSITSAMFLTAMAPNLLL 201

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11967935   242 QGQVNSIfpeNSNVVNFASWFGFAFPTMVILLLLAWLWLQVLFLGVNFRKNfgfgegeeerkqAAFQVIKTQHRLLGPMS 321
Cdd:pfam00939 202 LGLMNSI---LGVTITWASWFLAAIPPGVILLLLAPLLLYVLYPPEIKSVP------------DAKAIAKTELKELGPMT 266

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11967935   322 FAEKAVTFLFVLLVVLWFTREpgfFPGwgdtafankkgqsmVSDGTVAIFISLIMFIIPskipgltedpkkpgklkappa 401
Cdd:pfam00939 267 FREKALLGLFVLLLLLWIFGG---SLN--------------IDATTVAIIGLALMLLLR--------------------- 308

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11967935   402 ILTWK-TVNDKMPWNILILLGGGFALAKGSEESGLSKWLGDKLTPLQ--HVPPSATVLILSLLVAIFTECTSNVATTTLF 478
Cdd:pfam00939 309 ILDWKdIVKNKGAWNTLIWLGGLIMLANGLERSGFIEWLGNTLSTSLsgFSPAMAFIIILSLFYLSHYLFASATAHTAAM 388

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11967935   479 LPILASMAQAICLHP-LYVMLPCTLAASLA-FMLPVATPPNAIVFSFGGLKVSDMARAGFLLNIIGVLTITLSINSWSIP 556
Cdd:pfam00939 389 LPIFAAVAQAIPGAPpLLAALLLGFAISLGgFLTPYGTGPGPIYFGSGYLKVKDWWRIGAILTIIGLLILLLLGNWWWKP 468


                  ....
gi 11967935   557 IFKL 560
Cdd:pfam00939 469 LGSL 472
CitT COG0471
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
91-553 5.86e-89

Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];


Pssm-ID: 440239 [Multi-domain]  Cd Length: 369  Bit Score: 279.35  E-value: 5.86e-89
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11967935  91 VGGLMVAIAVEHWNLHKRIALGVLLIIGVRPALLLLGFMLVTAFLSMWISNTATTAMMLPIGYAVLEQLqgsqkdveegn 170
Cdd:COG0471   1 LGGFVLAAALEKTGLGRRIALLLLKRFGGSPLRLLLGLMLATALLSAFISNTARAAMMLPIALSIAAAL----------- 69

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11967935 171 snpsfelqeaspqkeetkldngqavsvssepraqKTKEHHRFSQGLSLCICYSASIGGIATLTGTTPNLVLQGQVNSIFP 250
Cdd:COG0471  70 ----------------------------------GSEKRSKFGSALLLPIAFAASIGGMGTLIGTPPNLIAAGLLEEATG 115

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11967935 251 ENsnvVNFASWFGFAFPTMVILLLLAwlwlqVLFLGVNFRKnfgfgegEEERKQAAFQVIKTQHRLLGPMSFAEKAVTFL 330
Cdd:COG0471 116 IP---ISFFEWMLVGLPVALVGLLLL-----WLVLYRLLPP-------EIKEVPGSKEVIREELAELGPLSRREKIALAI 180

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11967935 331 FVLLVVLWFTRepgffpgwgdtafankkGQSMVSDGTVAIFISLIMFIipskipgltedpkkpgklkapPAILTWKTVND 410
Cdd:COG0471 181 FALTVLLWITG-----------------SLHGIPIAVVALLGAVLLLL---------------------TGVLTWKDAYK 222

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11967935 411 KMPWNILILLGGGFALAKGSEESGLSKWLGDKLTP-LQHVPPSATVLILSLLVAIFTECTSNVATTTLFLPILASMAQAI 489
Cdd:COG0471 223 SIPWGVLLLFGGGLALGAALEKTGLAAWLADALLPlLGGLSPLLLLLLLALLTLLLTEFASNTATAALLLPIAISLAQAL 302

                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 11967935 490 CLHPLYVMLPCTLAASLAFMLPVATPPNAIVFSFGGLKVSDMARAGFLLNIIGVLTITLSINSW 553
Cdd:COG0471 303 GVNPLPLALAVAFAASCAFLLPVGTPPNAIVYGSGYYKFKDFLKVGLPLNLIGLVVLLLLGPLW 366
SLC13_permease cd01115
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ...
 42-553 4.90e-87

Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.


Pssm-ID: 238535 [Multi-domain]  Cd Length: 382  Bit Score: 274.85  E-value: 4.90e-87
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11967935  42 IILMALLWCTEALPLAVTALFPIILFPLMGIMEASKVCLEYFKDTNILFVGGLMVAIAVEHWNLHKRIALGVLLIIGVRP 121
Cdd:cd01115   4 LVFAAVLFVTEALPLDVTALLVPVLLVLLGVVPPKEAFSGFSDPAVILFLAGFILGAALTRTGLAKRIATKLLKRAGKGE 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11967935 122 ALLLLGFMLVTAFLSMWISNTATTAMMLPIGYAVLEQLQGSqkdveegnsnpsfelqeaspqkeetkldngqavsvssep 201
Cdd:cd01115  84 RRLLLLLMLVTAFLSAFMSNTATVAIMLPVALGLAAKLDIS--------------------------------------- 124

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11967935 202 raqktkehhrfSQGLSLCICYSASIGGIATLTGTTPNLVLQGQVNSIFPENsnvVNFASWFGFAFPTMVIllllawlwlq 281
Cdd:cd01115 125 -----------PSRLLMPLAFAASIGGMLTLIGTPPNLVASGYLESLGGQG---FSFFEFTPIGLPLLII---------- 180

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11967935 282 vlflgvnfrknfgfgegeeerkqaafqviktqhrllgpmsfaekavtflfVLLVVLWFTREPGFFPGWGDTAFAN-KKGQ 360
Cdd:cd01115 181 --------------------------------------------------GLLYLWFIFRLAVLIITIVLLAALAaITGL 210

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11967935 361 SMVSDGTVAIFISLIMFiipskipgltedpkkpgklkappAILTWKTVNDKMPWNILILLGGGFALAKGSEESGLSKWLG 440
Cdd:cd01115 211 LPVSVAIAIGAIVLVFG-----------------------GVLLTKEDYKSIDWGIIFLFAGGIPLGKALESSGAAALIA 267

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11967935 441 DKLTP-LQHVPPSATVLILSLLVAIFTECTSNVATTTLFLPILASMAQAICLHPLYVMLPCTLAASLAFMLPVATPPNAI 519
Cdd:cd01115 268 EALISlLGGLPPFAILLLLCLLTLVLTNFISNTATAVLLAPIALSIALSLGLPPEALLLAVAIGASCAFMLPVGTPPNAI 347

                       490       500       510
                ....*....|....*....|....*....|....
gi 11967935 520 VFSFGGLKVSDMARAGFLLNIIGVLTITLSINSW 553
Cdd:cd01115 348 VLGPGGYKFSDFAKVGLPLSILSLVVSVTMIPLI 381
dass TIGR00785
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally ...
 43-553 3.67e-57

anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273267 [Multi-domain]  Cd Length: 444  Bit Score: 198.34  E-value: 3.67e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11967935    43 ILMALLWCTEALPLAVTALFPI-ILFPLMGIMEASKV--CLEYFKDTNI-LFVGGLMVAIAVEHWNLHKRIALGVLLIIG 118
Cdd:TIGR00785  18 VAAIVGWILEPLPLPVTALLAIpIIAVLLGVLSAFKFknALSGFADPTIwLFFGAFILATALVKTGLGKRIAYKLVGKMG 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11967935   119 VRPALL-LLGFMLVTAFLSMWISNTA-TTAMMLPIGYAVLEQLqGSQKDveegnsnpsfelqeaspqkeetkldngqavs 196
Cdd:TIGR00785  98 GTTLGLgYFLVFLETLLAPMWPSNTArAGGILLPIIKSLLPLL-GSKPE------------------------------- 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11967935   197 vssepraqktKEHHRFSQGLSLCICYSASIGGIATLTGTTPNLVLQGQVNSIFpenSNVVNFASWFGFAFPTMVILLLLA 276
Cdd:TIGR00785 146 ----------KSPRKIGKYLMLGIAYSASIGSSGFLTGSAPNALAAGILSKIL---GIQISWGDWFLAGLPLGIILLLLV 212

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11967935   277 WLWLQVLFlgvnfrknfgfgEGEEERKQAAFQVIKTQHRLLGPMSFAEKAVTFLFVLLVVLWFtrepgffpgwgdtaFAN 356
Cdd:TIGR00785 213 PLLLYVLF------------PPELKLKDEVDLWAKEELEEMGPMSFREKALLGIFLLALLLWI--------------FGG 266

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11967935   357 KKGqsmVSDGTVAIFISLIMFIIpskipgltedpkkpgklkappAILTWKTVN-DKMPWNILILLGGGFALAKGSEESGL 435
Cdd:TIGR00785 267 SLG---INASVVALLAVVLMLFL---------------------GIVTWKDIQkNKVAWNTLILFGGLIGLAGGLKKSGF 322

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11967935   436 SKWLGDKL-TPLQHVPPSATVLILSLLVAIF-TECTSNVATTTLFLPILASMAQAICLHPLYVMLPCTLAASLA-FMLPV 512
Cdd:TIGR00785 323 IKWFSEKLvGILDGLSPTIAVLVLVVLFYIIlYFFASNTAHTAALVPIFFSVASAQGIPLELLALALALSASLMgFLTPY 402

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|.
gi 11967935   513 ATPPNAIVFSFGGLKVSDMARAGFLLNIIGVLTITLSINSW 553
Cdd:TIGR00785 403 ATPPNAIAYGSGYVKIKDMWRVGAIIGIVGLIVLLLVGTLW 443
ArsB_NhaD_permease cd00625
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, ...
 46-550 2.67e-45

Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump.


Pssm-ID: 238344 [Multi-domain]  Cd Length: 396  Bit Score: 164.73  E-value: 2.67e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11967935  46 ALLWCTEALPLAVTALFPIILFPLMGIMEASKVCLEYFKDTNILFVGGLMVAIAVEHWNLHKRIALgVLLIIGVRPALLL 125
Cdd:cd00625   1 YVLIRPEKLPRAVVALLGAVLLVLLGVVSPKEALSAIDWETILLLFGMMILSAALEETGLFDRLAA-KLARASKGSRRLL 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11967935 126 LGFMLVTAFLSMWISNTATTAMMLPIGYAVLEQLQGSqkdveegnsnpsfelqeaspqkeetkldngqavsvssepraqk 205
Cdd:cd00625  80 LLLMLLTAALSAFFSNDATAVLLTPIVLALLRKLGLS------------------------------------------- 116

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11967935 206 tkehhrFSQGLSLCICYSASIGGIATLTGTTPNLVLQGQVNsifpensnvVNFASWFGFAFPTMVILLLLAWLWLQVLFL 285
Cdd:cd00625 117 ------PPVPLLLALAFAANIGGAATPIGNPPNLIIASLSG---------LGFLDFLAFMAPPALGLLLLLLGLLYLLFR 181

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11967935 286 GVNFRKNFGFGEGEEERKQAAFQVIKtqhrllgpmsfaeKAVTFLFVLLVVLWFtrepgffpgwgdtAFANKKGQSMVSD 365
Cdd:cd00625 182 KKLLLPDEDKLTVLAEPLPARPLLKK-------------FLLLALLLLLLFVLL-------------FFFLIPLGLIALL 235

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11967935 366 GTVAIFISLIMFiipskipgltedpkkpgklkappaiLTWKTVNDKMPWNILILLGGGFALAKGSEESGLSKWLGDKLTP 445
Cdd:cd00625 236 GALLLLLLLVRG-------------------------LDPEEVLKSVDWGTLLFFAGLFVLVGALESTGLLEWLAELLVA 290

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11967935 446 LQHVPPSATVLILSLLVAIFTECTSNVATTTLFLPILASM-----AQAICLHPLYVMLPCTLAASLAFMLPVATPPNAIV 520
Cdd:cd00625 291 LVGLPPLAALLLIGLLSALLSNFISNVPTVALLLPIAASLappepAWLALALGSTLGGNLTLIGSLANLIPLGAAENAGV 370

                       490       500       510
                ....*....|....*....|....*....|
gi 11967935 521 fsfgGLKVSDMARAGFLLNIIGVLTITLSI 550
Cdd:cd00625 371 ----GISFGEFLKVGLPLTLLSLVVSLLYL 396
CitMHS pfam03600
Citrate transporter;
46-498 1.07e-29

Citrate transporter;


Pssm-ID: 460985 [Multi-domain]  Cd Length: 342  Bit Score: 120.11  E-value: 1.07e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11967935    46 ALLWCTEALPLAVTALFPIILFPLMGIMEASKVCLEYFKDTNILFVGGLMVAIAVEHWNLHKRIALGVLLIIGVRPALLL 125
Cdd:pfam03600   1 YVLIITEKLPRDVVALLGAVLLVLLGVLTPEEALSGIDSPTILLLLGMMIIGAILERTGLFDRLALKLLRLAGGKPRRLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11967935   126 LGFMLVTAFLSMWISNTATTAMMLPIGYAVLEQLqgsqkdveegNSNPSFelqeaspqkeetkldngqavsvssepraqk 205
Cdd:pfam03600  81 VALMLATALLSAFLSNDGTVLIMIPIVLALARRL----------GLPPSP------------------------------ 120

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11967935   206 tkehhrfsqgLSLCICYSASIGGIATLTGTTPNLVLQGQVNSIFPENSnvvnFASWFGFAFPTMVILlllawlwlqVLFL 285
Cdd:pfam03600 121 ----------LLIALAFAANIGGTATPIGDPPNIIIASALGLSFGDFG----FFMFPPVGVALLLVG---------LLPL 177

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11967935   286 GVNFRKNFGFGEGEEERKQAAFQVIKTQHRLLGPMSFAEKAVTFLFVLLVVLWFTrepgffpgwgdtafankkgqsmvsd 365
Cdd:pfam03600 178 LLIFRKLLPVRKEEEAELEELRKRAIKDKLLLAISALVLALVILGFLLLSVLALA------------------------- 232

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11967935   366 gtvaifISLIMFIIPskipgltedpkkpgklkappaILTWKTVNDKMPWNILILLGGGFALAKGSEESGLSKWLGDKLTP 445
Cdd:pfam03600 233 ------GALLLLLTG---------------------VLDPEEALKAVDWSTLLFFAGLFILVGALEKTGLADALADALGG 285

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|...
gi 11967935   446 LqhVPPSATVLILSLLVAIFTECTSNVATTTLFLPILASMAQAICLHPLYVML 498
Cdd:pfam03600 286 L--SGLLVALALILWLSALLSAFISNVPTAALMAPIIVGMAPAAGLGDPDPLA 336
CitMHS pfam03600
Citrate transporter;
399-548 3.07e-12

Citrate transporter;


Pssm-ID: 460985 [Multi-domain]  Cd Length: 342  Bit Score: 68.11  E-value: 3.07e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11967935   399 PPAILTWKTVNDKMPWNILILLGGGFALAKGSEESGLSKWLGDKLTPLQHVPPSATVLILSLLVAIFTECTSNVATTTLF 478
Cdd:pfam03600  24 LLGVLTPEEALSGIDSPTILLLLGMMIIGAILERTGLFDRLALKLLRLAGGKPRRLLVALMLATALLSAFLSNDGTVLIM 103

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 11967935   479 LPILASMAQAICLHPLYVMLPCTLAASLAFML-PVATPPNAIVFSFGGLKVSDMARAGFLLNIIGVLTITL 548
Cdd:pfam03600 104 IPIVLALARRLGLPPSPLLIALAFAANIGGTAtPIGDPPNIIIASALGLSFGDFGFFMFPPVGVALLLVGL 174
CitT COG0471
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
42-159 7.71e-11

Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];


Pssm-ID: 440239 [Multi-domain]  Cd Length: 369  Bit Score: 64.02  E-value: 7.71e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11967935  42 IILMALLWCTEA---LPLAVTALFPIILFPLMGIMEASkvclEYFKDTN----ILFVGGLMVAIAVEHWNLHKRIALGVL 114
Cdd:COG0471 181 FALTVLLWITGSlhgIPIAVVALLGAVLLLLTGVLTWK----DAYKSIPwgvlLLFGGGLALGAALEKTGLAAWLADALL 256

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 11967935 115 -LIIGVRPALLLLGFMLVTAFLSMWISNTATTAMMLPIGYAVLEQL 159
Cdd:COG0471 257 pLLGGLSPLLLLLLLALLTLLLTEFASNTATAALLLPIAISLAQAL 302
ArsB COG1055
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
54-507 8.19e-09

Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];


Pssm-ID: 440675 [Multi-domain]  Cd Length: 415  Bit Score: 57.83  E-value: 8.19e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11967935  54 LPLAVTALFPIILFPLMGIMEASKVcLEYFkDTN-ILFVGGLMVAIAV-EHWNLHKRIALGVLLIIGVRPALLLLGFMLV 131
Cdd:COG1055  23 LNRAVAALLGAALLLLLGVVSLEDA-LEAI-DWNtILFLLGMMIIVAIlDESGFFEWLAIKLARRAKGSPRRLLWLLGLL 100

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11967935 132 TAFLSMWISNTATTAMMLPIGYAVLEQLQGSqkdveegnsnpsfelqeaspqkeetkldngqavsvssePRAqktkehhr 211
Cdd:COG1055 101 TALLSAFLDNDTTALLLTPVVLAIARRLGLN--------------------------------------PVP-------- 134

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11967935 212 fsqgLSLCICYSASIGGIATLTGTTPNLVLQGQVNsifpensnvVNFASWFGFAFPTMVILLLLAwlwlqVLFLGVNFRK 291
Cdd:COG1055 135 ----FLIAIVFAANIGGAATPIGNPTNIMIASAGG---------LSFLDFLANLFPPSLVSLLVT-----LLVLYLLFRK 196

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11967935 292 NFgfgegeeerkQAAFQVIKTQHRLLGPMSFAEKAVTFLFVLLVVLWFTREPGFFPGWgdtafankkgqsmvsdgtVAIF 371
Cdd:COG1055 197 EL----------PAAPDLEDDPKEAIKDRRLLRISLLVLALLLVGFVLHSFLGLPPAL------------------IALL 248

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11967935 372 ISLIMFIIpSKIPgltedpkkpgklkaPPAILTwktvndKMPWNILILLGGGFALAKGSEESGLSKWLGDKLTPLQHVPP 451
Cdd:COG1055 249 GAAVLLLL-ARVD--------------VREVLK------KVDWSTLLFFIGLFVVVGGLENTGLLDLLAELLASLTGGNL 307

                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 11967935 452 SATVLILSLLVAIFTECTSNVATTTLFLPILASMAQAICLHPLYVMLpcTLAASLA 507
Cdd:COG1055 308 LLAALLILWLSAILSAVVDNVPLVAALLPLIPDLGATGNPEPLWLAL--ALGATLG 361
ArsB COG1055
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
402-548 1.44e-08

Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];


Pssm-ID: 440675 [Multi-domain]  Cd Length: 415  Bit Score: 57.06  E-value: 1.44e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11967935 402 ILTWKTVNDKMPWNILILLGGGFALAKGSEESGLSKWLGDKLTPLQHVPPSATVLILSLLVAIFTECTSNVATTTLFLPI 481
Cdd:COG1055  41 VVSLEDALEAIDWNTILFLLGMMIIVAILDESGFFEWLAIKLARRAKGSPRRLLWLLGLLTALLSAFLDNDTTALLLTPV 120

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 11967935 482 LASMAQAICLHPLYVMLPCTLAASLA-FMLPVATPPNAIVFSFGGLKVSDMARAGFLLNIIGVLTITL 548
Cdd:COG1055 121 VLAIARRLGLNPVPFLIAIVFAANIGgAATPIGNPTNIMIASAGGLSFLDFLANLFPPSLVSLLVTLL 188
CitMHS pfam03600
Citrate transporter;
8-165 3.12e-08

Citrate transporter;


Pssm-ID: 460985 [Multi-domain]  Cd Length: 342  Bit Score: 55.78  E-value: 3.12e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11967935     8 LWAYRSYLIVLCLPIFLLPLPLIVQTKEAYCAYSIILMALLWCTEALPLAVTALFPIILFPLMGIMEASKVCLEYFKDTN 87
Cdd:pfam03600 178 LLIFRKLLPVRKEEEAELEELRKRAIKDKLLLAISALVLALVILGFLLLSVLALAGALLLLLTGVLDPEEALKAVDWSTL 257

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 11967935    88 ILFVGGLMVAIAVEHWNLHKriALGVLLIIGVRPALLLLGFMLVTAFLSMWISNTATTAMMLPIGYAVLEQLQGSQKD 165
Cdd:pfam03600 258 LFFAGLFILVGALEKTGLAD--ALADALGGLSGLLVALALILWLSALLSAFISNVPTAALMAPIIVGMAPAAGLGDPD 333
ArsB_NhaD_permease cd00625
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, ...
 42-151 4.69e-06

Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump.


Pssm-ID: 238344 [Multi-domain]  Cd Length: 396  Bit Score: 49.17  E-value: 4.69e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11967935  42 IILMALLWCTEALPLAVTALFPIILFPLMGIMEASKVCLEYFK-DTNILFVGGLMVAIAVEHWNLHKRIALGVLLIIGVR 120
Cdd:cd00625 216 LLLFVLLFFFLIPLGLIALLGALLLLLLLVRGLDPEEVLKSVDwGTLLFFAGLFVLVGALESTGLLEWLAELLVALVGLP 295

                        90       100       110
                ....*....|....*....|....*....|.
gi 11967935 121 PALLLLGFMLVTAFLSMWISNTATTAMMLPI 151
Cdd:cd00625 296 PLAALLLIGLLSALLSNFISNVPTVALLLPI 326
P_permease cd01116
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible ...
 400-531 1.79e-03

Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the intraorganelle pH, together with the ATP-driven proton pump. It shows significant sequence similarity to the Na+/H+ antiporter NhaD from Vibrio parahaemolyticus. Both proteins belong to ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease contains 8-13 transmembrane domains.


Pssm-ID: 238536 [Multi-domain]  Cd Length: 413  Bit Score: 41.08  E-value: 1.79e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11967935 400 PAILTWKTVNDKMPWNILILLGGGFALAKGSEESGLSKWLGDKLTPLQHVPPSATVLILSLLVAIFTECTSNVATTTLFL 479
Cdd:cd01116  33 TLSPDLETIVSWVDWETLALLLGMMIIVSILSETGVFEYLAIWAVKISKGRPWRLLLLLGLLTAFLSAFLDNVTTVLLMV 112

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 11967935 480 PILASMAQAICLHPLYVMLPCTLAASLAFML-PVATPPNAIVFSFGGLKVSDM 531
Cdd:cd01116 113 PVTIRLCEVLGLNPVPVLISEVIAANIGGAAtLIGDPPNIMIGSAAGLTFNDF 165
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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