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Conserved domains on  [gi|170763515|ref|NP_071443|]
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doublesex- and mab-3-related transcription factor A1 [Homo sapiens]

Protein Classification

DMRTA1 family protein( domain architecture ID 10465233)

doublesex- and mab-3-related transcription factor A1 (DMRTA1) family protein may function as regulator of sex differentiation in vertebrate

Gene Ontology:  GO:0003677|GO:0007548
PubMed:  22310892|22425532

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DMRT5_DMB pfam20624
DMRT5, DMB domain; This is the DMB domain found at the C-terminal of DMRT5 proteins (doublesex ...
 405-491 2.87e-52

DMRT5, DMB domain; This is the DMB domain found at the C-terminal of DMRT5 proteins (doublesex and mab-3 related transcription factor, also known as Doublesex- and mab-3-related transcription factor A2). These proteins are involved in sexual development although not restricted to the developing gonads in vertebrates. DMRT5, together with DMRT4, has been identified as an important regulator of neurogenesis. This domain is adjacent the DMA domain (pfam03474), both of which are required for neuronal differentiation.


:

Pssm-ID: 466773  Cd Length: 88  Bit Score: 171.67  E-value: 2.87e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170763515  405 NKSAFSPLQTTSASYGGDSSLYGVNPRVGISPLRLAYSSAGRGLSGFMSPYLTPGLVPTLPFRPALDYAFSGMIRDSSYL 484
Cdd:pfam20624   1 SKSAFSPLQTSSASFGGESNLYGLNPRLGISPLRLAYSSPGRGLPGFMSPYLTSGLVPALPFRPPLDYSFPGMIRDLSYL 80


                  ....*..
gi 170763515  485 SSKDSIT 491
Cdd:pfam20624  81 QSKDSLC 87
DM pfam00751
DM DNA binding domain; The DM domain is named after dsx and mab-3. dsx contains a single ...
 93-139 9.69e-30

DM DNA binding domain; The DM domain is named after dsx and mab-3. dsx contains a single amino-terminal DM domain, whereas mab-3 contains two amino-terminal domains. The DM domain has a pattern of conserved zinc chelating residues C2H2C4. The dsx DM domain has been shown to dimerize and bind palindromic DNA.


:

Pssm-ID: 459924  Cd Length: 47  Bit Score: 110.45  E-value: 9.69e-30
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 170763515   93 RTPKCARCRNHGVVSALKGHKRFCRWRDCACAKCTLIAERQRVMAAQ 139
Cdd:pfam00751   1 RSPKCARCRNHGVRVPLKGHKRYCPYRDCSCPKCLLVAERQRVMAAQ 47
CUE_DMA_DMRTA1 cd14417
CUE-like DMA domain found in doublesex- and mab-3-related transcription factor A1 (DMRTA1) and ...
 325-364 7.38e-19

CUE-like DMA domain found in doublesex- and mab-3-related transcription factor A1 (DMRTA1) and similar proteins; DMRTA1 is encoded by gene DMRT1, a vertebrate equivalent of the Drosophila melanogaster master sex regulator gene, doublesex. In D. melanogaster, doublesex controls the terminal switch of the pathway leading to sex fate choice. DMRT1 may function as regulator of sex differentiation in vertebrate. Especially, it is required for testis differentiation, but is not involved in the gonadal sex fate choice.


:

Pssm-ID: 270600  Cd Length: 40  Bit Score: 79.63  E-value: 7.38e-19
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 170763515 325 RPRDPLDILTKIFPNYRRSRLEGILRFCKGDVVQAIEQVL 364
Cdd:cd14417    1 RHRDPLDILTRVFPNHKRNALESILRRCRGDVVQAIEQLL 40
 
Name Accession Description Interval E-value
DMRT5_DMB pfam20624
DMRT5, DMB domain; This is the DMB domain found at the C-terminal of DMRT5 proteins (doublesex ...
 405-491 2.87e-52

DMRT5, DMB domain; This is the DMB domain found at the C-terminal of DMRT5 proteins (doublesex and mab-3 related transcription factor, also known as Doublesex- and mab-3-related transcription factor A2). These proteins are involved in sexual development although not restricted to the developing gonads in vertebrates. DMRT5, together with DMRT4, has been identified as an important regulator of neurogenesis. This domain is adjacent the DMA domain (pfam03474), both of which are required for neuronal differentiation.


Pssm-ID: 466773  Cd Length: 88  Bit Score: 171.67  E-value: 2.87e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170763515  405 NKSAFSPLQTTSASYGGDSSLYGVNPRVGISPLRLAYSSAGRGLSGFMSPYLTPGLVPTLPFRPALDYAFSGMIRDSSYL 484
Cdd:pfam20624   1 SKSAFSPLQTSSASFGGESNLYGLNPRLGISPLRLAYSSPGRGLPGFMSPYLTSGLVPALPFRPPLDYSFPGMIRDLSYL 80


                  ....*..
gi 170763515  485 SSKDSIT 491
Cdd:pfam20624  81 QSKDSLC 87
DM pfam00751
DM DNA binding domain; The DM domain is named after dsx and mab-3. dsx contains a single ...
 93-139 9.69e-30

DM DNA binding domain; The DM domain is named after dsx and mab-3. dsx contains a single amino-terminal DM domain, whereas mab-3 contains two amino-terminal domains. The DM domain has a pattern of conserved zinc chelating residues C2H2C4. The dsx DM domain has been shown to dimerize and bind palindromic DNA.


Pssm-ID: 459924  Cd Length: 47  Bit Score: 110.45  E-value: 9.69e-30
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 170763515   93 RTPKCARCRNHGVVSALKGHKRFCRWRDCACAKCTLIAERQRVMAAQ 139
Cdd:pfam00751   1 RSPKCARCRNHGVRVPLKGHKRYCPYRDCSCPKCLLVAERQRVMAAQ 47
DM smart00301
Doublesex DNA-binding motif;
93-146 4.87e-24

Doublesex DNA-binding motif;


Pssm-ID: 214606  Cd Length: 54  Bit Score: 94.74  E-value: 4.87e-24
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 170763515    93 RTPKCARCRNHGVVSALKGHKRFCRWRDCACAKCTLIAERQRVMAAQVALRRQQ 146
Cdd:smart00301   1 RIPYCQKCENHGVKVPLKGHKPECPFRDCECEKCTLVEKRRALMALQIKLKREQ 54
CUE_DMA_DMRTA1 cd14417
CUE-like DMA domain found in doublesex- and mab-3-related transcription factor A1 (DMRTA1) and ...
 325-364 7.38e-19

CUE-like DMA domain found in doublesex- and mab-3-related transcription factor A1 (DMRTA1) and similar proteins; DMRTA1 is encoded by gene DMRT1, a vertebrate equivalent of the Drosophila melanogaster master sex regulator gene, doublesex. In D. melanogaster, doublesex controls the terminal switch of the pathway leading to sex fate choice. DMRT1 may function as regulator of sex differentiation in vertebrate. Especially, it is required for testis differentiation, but is not involved in the gonadal sex fate choice.


Pssm-ID: 270600  Cd Length: 40  Bit Score: 79.63  E-value: 7.38e-19
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 170763515 325 RPRDPLDILTKIFPNYRRSRLEGILRFCKGDVVQAIEQVL 364
Cdd:cd14417    1 RHRDPLDILTRVFPNHKRNALESILRRCRGDVVQAIEQLL 40
DMA pfam03474
DMRTA motif; This region is found to the C-terminus of the pfam00751. DM-domain proteins with ...
 327-362 1.06e-17

DMRTA motif; This region is found to the C-terminus of the pfam00751. DM-domain proteins with this motif are known as DMRTA proteins. The function of this region is unknown.


Pssm-ID: 460937  Cd Length: 36  Bit Score: 76.45  E-value: 1.06e-17
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 170763515  327 RDPLDILTKIFPNYRRSRLEGILRFCKGDVVQAIEQ 362
Cdd:pfam03474   1 RSPLDILMRVFPNHKRSVLELVLQRCNGDVVQAIEQ 36
 
Name Accession Description Interval E-value
DMRT5_DMB pfam20624
DMRT5, DMB domain; This is the DMB domain found at the C-terminal of DMRT5 proteins (doublesex ...
 405-491 2.87e-52

DMRT5, DMB domain; This is the DMB domain found at the C-terminal of DMRT5 proteins (doublesex and mab-3 related transcription factor, also known as Doublesex- and mab-3-related transcription factor A2). These proteins are involved in sexual development although not restricted to the developing gonads in vertebrates. DMRT5, together with DMRT4, has been identified as an important regulator of neurogenesis. This domain is adjacent the DMA domain (pfam03474), both of which are required for neuronal differentiation.


Pssm-ID: 466773  Cd Length: 88  Bit Score: 171.67  E-value: 2.87e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170763515  405 NKSAFSPLQTTSASYGGDSSLYGVNPRVGISPLRLAYSSAGRGLSGFMSPYLTPGLVPTLPFRPALDYAFSGMIRDSSYL 484
Cdd:pfam20624   1 SKSAFSPLQTSSASFGGESNLYGLNPRLGISPLRLAYSSPGRGLPGFMSPYLTSGLVPALPFRPPLDYSFPGMIRDLSYL 80


                  ....*..
gi 170763515  485 SSKDSIT 491
Cdd:pfam20624  81 QSKDSLC 87
DM pfam00751
DM DNA binding domain; The DM domain is named after dsx and mab-3. dsx contains a single ...
 93-139 9.69e-30

DM DNA binding domain; The DM domain is named after dsx and mab-3. dsx contains a single amino-terminal DM domain, whereas mab-3 contains two amino-terminal domains. The DM domain has a pattern of conserved zinc chelating residues C2H2C4. The dsx DM domain has been shown to dimerize and bind palindromic DNA.


Pssm-ID: 459924  Cd Length: 47  Bit Score: 110.45  E-value: 9.69e-30
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 170763515   93 RTPKCARCRNHGVVSALKGHKRFCRWRDCACAKCTLIAERQRVMAAQ 139
Cdd:pfam00751   1 RSPKCARCRNHGVRVPLKGHKRYCPYRDCSCPKCLLVAERQRVMAAQ 47
DM smart00301
Doublesex DNA-binding motif;
93-146 4.87e-24

Doublesex DNA-binding motif;


Pssm-ID: 214606  Cd Length: 54  Bit Score: 94.74  E-value: 4.87e-24
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 170763515    93 RTPKCARCRNHGVVSALKGHKRFCRWRDCACAKCTLIAERQRVMAAQVALRRQQ 146
Cdd:smart00301   1 RIPYCQKCENHGVKVPLKGHKPECPFRDCECEKCTLVEKRRALMALQIKLKREQ 54
CUE_DMA_DMRTA1 cd14417
CUE-like DMA domain found in doublesex- and mab-3-related transcription factor A1 (DMRTA1) and ...
 325-364 7.38e-19

CUE-like DMA domain found in doublesex- and mab-3-related transcription factor A1 (DMRTA1) and similar proteins; DMRTA1 is encoded by gene DMRT1, a vertebrate equivalent of the Drosophila melanogaster master sex regulator gene, doublesex. In D. melanogaster, doublesex controls the terminal switch of the pathway leading to sex fate choice. DMRT1 may function as regulator of sex differentiation in vertebrate. Especially, it is required for testis differentiation, but is not involved in the gonadal sex fate choice.


Pssm-ID: 270600  Cd Length: 40  Bit Score: 79.63  E-value: 7.38e-19
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 170763515 325 RPRDPLDILTKIFPNYRRSRLEGILRFCKGDVVQAIEQVL 364
Cdd:cd14417    1 RHRDPLDILTRVFPNHKRNALESILRRCRGDVVQAIEQLL 40
DMA pfam03474
DMRTA motif; This region is found to the C-terminus of the pfam00751. DM-domain proteins with ...
 327-362 1.06e-17

DMRTA motif; This region is found to the C-terminus of the pfam00751. DM-domain proteins with this motif are known as DMRTA proteins. The function of this region is unknown.


Pssm-ID: 460937  Cd Length: 36  Bit Score: 76.45  E-value: 1.06e-17
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 170763515  327 RDPLDILTKIFPNYRRSRLEGILRFCKGDVVQAIEQ 362
Cdd:pfam03474   1 RSPLDILMRVFPNHKRSVLELVLQRCNGDVVQAIEQ 36
CUE_DMA cd14370
CUE-like DMA domain found in the DM domain gene family encodes putative transcription factors ...
 325-364 3.93e-15

CUE-like DMA domain found in the DM domain gene family encodes putative transcription factors DMRTA1, DMRTA2 and DMRTA3; The DM domain proteins are related to the sexual regulators doublesex from Drosophila melanogaster and MAB-3 from Caenorhabditis elegans. Thus, they have been named as doublesex- and mab-3-related transcription factors and may be involved in sexual development or in somite development. All DM domain proteins contain a DM domain which is an unusual zinc finger motif. In addition to an N-terminal DM domain, members in this family, including DMRTA1, DMRTA2 and DMRTA3, also harbor additional CUE-like DMA domain. DMRTA1 is encoded by gene DMRT1, a vertebrate equivalent of the D. melanogaster master sex regulator gene, doublesex. In D. melanogaster, doublesex controls the terminal switch of the pathway leading to sex fate choice. DMRT1 may function as regulator of sex differentiation in vertebrate. Especially, it is required for testis differentiation, but is not involved in the gonadal sex fate choice. DMRTA2, also called Doublesex- and mab-3-related transcription factor 5 (DMRT5), is encoded by gene DMRT2. In the zebrafish, DMRT2 is involved in somite development. DMRTA2 may act as an activator of cyclin-dependent kinase inhibitor 2C (cdkn2c) during spermatogenesis. It may also play significant roles in embryonic neurogenesis. DMRTA3 is encoded by tumor suppressor gene DMRT3 which serves as a novel potential target for homozygous deletion in squamous cell carcinoma of the lung.


Pssm-ID: 270553  Cd Length: 40  Bit Score: 69.13  E-value: 3.93e-15
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 170763515 325 RPRDPLDILTKIFPNYRRSRLEGILRFCKGDVVQAIEQVL 364
Cdd:cd14370    1 SRRSPIELLTRLFPHQKRSVLELILQGCGGDLVQAIEQVL 40
CUE_DMA_DMRTA2 cd14418
CUE-like DMA domain found in doublesex- and mab-3-related transcription factor A2 (DMRTA2); ...
 325-365 5.29e-14

CUE-like DMA domain found in doublesex- and mab-3-related transcription factor A2 (DMRTA2); DMRTA2, also called Doublesex- and mab-3-related transcription factor 5 (DMRT5), is encoded by gene DMRT2. In the zebrafish, DMRT2 is involved in somite development. DMRTA2 may act as an activator of cyclin-dependent kinase inhibitor 2C (cdkn2c) during spermatogenesis. It may also play significant roles in embryonic neurogenesis.


Pssm-ID: 270601  Cd Length: 42  Bit Score: 66.10  E-value: 5.29e-14
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 170763515 325 RPRDPLDILTKIFPNYRRSRLEGILRFCKGDVVQAIEQVLN 365
Cdd:cd14418    1 RQRTPIDILTRVFPGHKRSVLELVLQGCGGDVVQAIEQILN 41
CUE_DMA_DMRTA3 cd14419
CUE-like DMA domain found in doublesex- and mab-3-related transcription factor 3 (DMRTA3); ...
 323-367 1.17e-06

CUE-like DMA domain found in doublesex- and mab-3-related transcription factor 3 (DMRTA3); DMRTA3 is encoded by tumor suppressor gene DMRT3 which serves as a novel potential target for homozygous deletion in squamous cell carcinoma of the lung.


Pssm-ID: 270602  Cd Length: 43  Bit Score: 45.19  E-value: 1.17e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 170763515 323 SSRPrdPLDILTKIFPNYRRSRLEGILRFCKGDVVQAIEQVLNGK 367
Cdd:cd14419    1 ANRP--PLEVLKKIFPSHKPTVLELILKGCGGDLVSAIEVLLSSR 43
CUE cd14279
CUE domain found in ubiquitin-binding CUE proteins; This family includes many coupling of ...
 328-364 6.91e-04

CUE domain found in ubiquitin-binding CUE proteins; This family includes many coupling of ubiquitin conjugation to endoplasmic reticulum degradation (CUE) domain containing proteins that are characterized by an FP and a di-leucine-like sequence and bind to monoubiquitin with varying affinities. Some higher eukaryotic CUE domain proteins do not bind monoubiquitin efficiently, since they carry LP, rather than FP among CUE domains. CUE domains form three-helix bundle structures and are distantly related to the ubiquitin-associated (UBA) domains which are widely occurring ubiquitin-binding motifs found in a broad range of cellular proteins in species ranging from yeast to human. The majority of family members contain one CUE domain, but some family members from fungi harbor two CUE domains.


Pssm-ID: 270465  Cd Length: 38  Bit Score: 37.06  E-value: 6.91e-04
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 170763515 328 DPLDILTKIFPNYRRSRLEGILRFCKGDVVQAIEQVL 364
Cdd:cd14279    2 EKLEQLQEMFPDLDEEVLEDVLEANNGDVEAAIDALL 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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