NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|209364544|ref|NP_071414|]
View 

calsyntenin-2 precursor [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
CLSTN_C super family cl45102
Calsyntenin C-terminal; This is the cytoplasmic C-terminal domain of clasyntenin (CLSTN) ...
 546-892 3.22e-156

Calsyntenin C-terminal; This is the cytoplasmic C-terminal domain of clasyntenin (CLSTN) proteins 1, 2 and 3 (also known as Alcadein-alpha, gamma and beta). These are postsynaptic Ca2-binding proteins, evolutionarily conserved type I membrane proteins. CLSTN forms a complex with APP and X11-like that stabilizes both APP and CLSTN proteins metabolically. CLSTN strongly associates with kinesin-1 light chains (KLC1) that induce kinesin-1 association with vesicles and functions as a novel cargo in axonal anterograde transport. This domain includes the WD motifs required for KLC1 interaction (although one WD motif is sufficient), and the NP motif.


The actual alignment was detected with superfamily member pfam19699:

Pssm-ID: 466150  Cd Length: 354  Bit Score: 463.86  E-value: 3.22e-156
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209364544  546 DINSLESLGQGIKYHFNPSQSILVMEGDDIGNINRALQKVSYINSRQFPTAGVRRLKVSSKVQCFGEDVCISIPEVDAYV 625
Cdd:pfam19699   1 DLQDPENSGSGVKVHFNPSQSVLTLEGDDIESLNKAMQHVSYVNSRQFPTPGVRRLKLTTSVKCFNEESCISIPDVEGYV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209364544  626 MVLQAIEPRITLRGTDHFWRPAAQFESARGVTLFPDIKIVSTFAK---TEAPGDVKTTDPKSEVLEEMLHNLDFCDILVI 702
Cdd:pfam19699  81 MVLQPEEPKISLSGIDHFARPASEFESPEGVPLFPELRIVSTITReveSEGDGEDDPTVQESLVSEEIVHNLDGCEVTVL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209364544  703 GGDLDPRQECLELNHSELHQRHLDATNSTAGYSIYGVGSMSRYEQVLHHIRYRNWRPASLEARRFRIKCSELNGRYTSNE 782
Cdd:pfam19699 161 GEELNPEQESLEVDMALLQQRGLEISSSTLGITITGVESMASYEEVLHLIRYRNWNTESLFERKFKLSCSELNGRYASNE 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209364544  783 FNLEVSILHedQVSDKEHVNHLIVQPPFLQSVHH--PE----SRSSIQHSSVVPSIATVVIIISVCMLVFVVAMGVYRVR 856
Cdd:pfam19699 241 FKVEVNVLH--TANPVEHPNHMAAQPQFVHPVHHafPDlsghNLANPHPSSVVPSAATVVIVVCVSFLVFMIILGVFRIR 318

                         330       340       350
                  ....*....|....*....|....*....|....*.
gi 209364544  857 IAHQHFIQETEAAKESEMDWDDSALTITVNPMEKHE 892
Cdd:pfam19699 319 SAHQRGMRDQEGGKENEMDWDDSALTITVNPMETYE 354
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 165-256 5.04e-13

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 65.80  E-value: 5.04e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209364544 165 YKAVVTEG-KIYDSILQVEAIDEDcSPQYSQIcNYEIVTTDV--PFAIDRN-GNIRNTEKLSYDKQHQYEILVTAYDCGQ 240
Cdd:cd11304    2 YEVSVPENaPPGTVVLTVSATDPD-SGENGEV-TYSIVSGNEdgLFSIDPStGEITTAKPLDREEQSSYTLTVTATDGGG 79

                         90
                 ....*....|....*.
gi 209364544 241 KPAAQDTLVQVDVKPV 256
Cdd:cd11304   80 PPLSSTATVTITVLDV 95
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 47-155 4.64e-12

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 63.10  E-value: 4.64e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209364544  47 SYHGVITENN--DTVILDppLVALDKDAPVPfaGEIcAFKIHGQElPFEAVVLNKTSGEgrLRAKSPIDCELQKEYTFII 124
Cdd:cd11304    1 SYEVSVPENAppGTVVLT--VSATDPDSGEN--GEV-TYSIVSGN-EDGLFSIDPSTGE--ITTAKPLDREEQSSYTLTV 72

                         90       100       110
                 ....*....|....*....|....*....|.
gi 209364544 125 QAYDCGAGPHETawkkshKAVVHIQVKDVNE 155
Cdd:cd11304   73 TATDGGGPPLSS------TATVTITVLDVND 97
 
Name Accession Description Interval E-value
CLSTN_C pfam19699
Calsyntenin C-terminal; This is the cytoplasmic C-terminal domain of clasyntenin (CLSTN) ...
 546-892 3.22e-156

Calsyntenin C-terminal; This is the cytoplasmic C-terminal domain of clasyntenin (CLSTN) proteins 1, 2 and 3 (also known as Alcadein-alpha, gamma and beta). These are postsynaptic Ca2-binding proteins, evolutionarily conserved type I membrane proteins. CLSTN forms a complex with APP and X11-like that stabilizes both APP and CLSTN proteins metabolically. CLSTN strongly associates with kinesin-1 light chains (KLC1) that induce kinesin-1 association with vesicles and functions as a novel cargo in axonal anterograde transport. This domain includes the WD motifs required for KLC1 interaction (although one WD motif is sufficient), and the NP motif.


Pssm-ID: 466150  Cd Length: 354  Bit Score: 463.86  E-value: 3.22e-156
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209364544  546 DINSLESLGQGIKYHFNPSQSILVMEGDDIGNINRALQKVSYINSRQFPTAGVRRLKVSSKVQCFGEDVCISIPEVDAYV 625
Cdd:pfam19699   1 DLQDPENSGSGVKVHFNPSQSVLTLEGDDIESLNKAMQHVSYVNSRQFPTPGVRRLKLTTSVKCFNEESCISIPDVEGYV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209364544  626 MVLQAIEPRITLRGTDHFWRPAAQFESARGVTLFPDIKIVSTFAK---TEAPGDVKTTDPKSEVLEEMLHNLDFCDILVI 702
Cdd:pfam19699  81 MVLQPEEPKISLSGIDHFARPASEFESPEGVPLFPELRIVSTITReveSEGDGEDDPTVQESLVSEEIVHNLDGCEVTVL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209364544  703 GGDLDPRQECLELNHSELHQRHLDATNSTAGYSIYGVGSMSRYEQVLHHIRYRNWRPASLEARRFRIKCSELNGRYTSNE 782
Cdd:pfam19699 161 GEELNPEQESLEVDMALLQQRGLEISSSTLGITITGVESMASYEEVLHLIRYRNWNTESLFERKFKLSCSELNGRYASNE 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209364544  783 FNLEVSILHedQVSDKEHVNHLIVQPPFLQSVHH--PE----SRSSIQHSSVVPSIATVVIIISVCMLVFVVAMGVYRVR 856
Cdd:pfam19699 241 FKVEVNVLH--TANPVEHPNHMAAQPQFVHPVHHafPDlsghNLANPHPSSVVPSAATVVIVVCVSFLVFMIILGVFRIR 318

                         330       340       350
                  ....*....|....*....|....*....|....*.
gi 209364544  857 IAHQHFIQETEAAKESEMDWDDSALTITVNPMEKHE 892
Cdd:pfam19699 319 SAHQRGMRDQEGGKENEMDWDDSALTITVNPMETYE 354
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 165-256 5.04e-13

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 65.80  E-value: 5.04e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209364544 165 YKAVVTEG-KIYDSILQVEAIDEDcSPQYSQIcNYEIVTTDV--PFAIDRN-GNIRNTEKLSYDKQHQYEILVTAYDCGQ 240
Cdd:cd11304    2 YEVSVPENaPPGTVVLTVSATDPD-SGENGEV-TYSIVSGNEdgLFSIDPStGEITTAKPLDREEQSSYTLTVTATDGGG 79

                         90
                 ....*....|....*.
gi 209364544 241 KPAAQDTLVQVDVKPV 256
Cdd:cd11304   80 PPLSSTATVTITVLDV 95
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 47-155 4.64e-12

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 63.10  E-value: 4.64e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209364544  47 SYHGVITENN--DTVILDppLVALDKDAPVPfaGEIcAFKIHGQElPFEAVVLNKTSGEgrLRAKSPIDCELQKEYTFII 124
Cdd:cd11304    1 SYEVSVPENAppGTVVLT--VSATDPDSGEN--GEV-TYSIVSGN-EDGLFSIDPSTGE--ITTAKPLDREEQSSYTLTV 72

                         90       100       110
                 ....*....|....*....|....*....|.
gi 209364544 125 QAYDCGAGPHETawkkshKAVVHIQVKDVNE 155
Cdd:cd11304   73 TATDGGGPPLSS------TATVTITVLDVND 97
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 66-158 6.80e-10

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 56.20  E-value: 6.80e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209364544    66 VALDKDAPVPfaGEIcAFKIHGQElPFEAVVLNKTSGEgrLRAKSPIDCELQKEYTFIIQAYDCGAGPHETawkkshKAV 145
Cdd:smart00112   1 SATDADSGEN--GKV-TYSILSGN-DDGLFSIDPETGE--ITTTKPLDREEQPEYTLTVEATDGGGPPLSS------TAT 68

                           90
                   ....*....|...
gi 209364544   146 VHIQVKDVNEFAP 158
Cdd:smart00112  69 VTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 183-254 5.74e-08

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 50.81  E-value: 5.74e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 209364544   183 AIDEDcSPQYSQIcNYEIV--TTDVPFAIDRN-GNIRNTEKLSYDKQHQYEILVTAYDCGQKPAAQDTLVQVDVK 254
Cdd:smart00112   2 ATDAD-SGENGKV-TYSILsgNDDGLFSIDPEtGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVL 74
Cadherin pfam00028
Cadherin domain;
177-253 5.20e-07

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 48.45  E-value: 5.20e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209364544  177 SILQVEAIDEDCSPQySQIcNYEIVTTDVP--FAIDR-NGNIRNTEKLSYDKQHQYEILVTAYDCGQKPAAQDTLVQVDV 253
Cdd:pfam00028  14 EVLTVTATDPDLGPN-GRI-FYSILGGGPGgnFRIDPdTGDISTTKPLDRESIGEYELTVEATDSGGPPLSSTATVTITV 91
 
Name Accession Description Interval E-value
CLSTN_C pfam19699
Calsyntenin C-terminal; This is the cytoplasmic C-terminal domain of clasyntenin (CLSTN) ...
 546-892 3.22e-156

Calsyntenin C-terminal; This is the cytoplasmic C-terminal domain of clasyntenin (CLSTN) proteins 1, 2 and 3 (also known as Alcadein-alpha, gamma and beta). These are postsynaptic Ca2-binding proteins, evolutionarily conserved type I membrane proteins. CLSTN forms a complex with APP and X11-like that stabilizes both APP and CLSTN proteins metabolically. CLSTN strongly associates with kinesin-1 light chains (KLC1) that induce kinesin-1 association with vesicles and functions as a novel cargo in axonal anterograde transport. This domain includes the WD motifs required for KLC1 interaction (although one WD motif is sufficient), and the NP motif.


Pssm-ID: 466150  Cd Length: 354  Bit Score: 463.86  E-value: 3.22e-156
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209364544  546 DINSLESLGQGIKYHFNPSQSILVMEGDDIGNINRALQKVSYINSRQFPTAGVRRLKVSSKVQCFGEDVCISIPEVDAYV 625
Cdd:pfam19699   1 DLQDPENSGSGVKVHFNPSQSVLTLEGDDIESLNKAMQHVSYVNSRQFPTPGVRRLKLTTSVKCFNEESCISIPDVEGYV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209364544  626 MVLQAIEPRITLRGTDHFWRPAAQFESARGVTLFPDIKIVSTFAK---TEAPGDVKTTDPKSEVLEEMLHNLDFCDILVI 702
Cdd:pfam19699  81 MVLQPEEPKISLSGIDHFARPASEFESPEGVPLFPELRIVSTITReveSEGDGEDDPTVQESLVSEEIVHNLDGCEVTVL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209364544  703 GGDLDPRQECLELNHSELHQRHLDATNSTAGYSIYGVGSMSRYEQVLHHIRYRNWRPASLEARRFRIKCSELNGRYTSNE 782
Cdd:pfam19699 161 GEELNPEQESLEVDMALLQQRGLEISSSTLGITITGVESMASYEEVLHLIRYRNWNTESLFERKFKLSCSELNGRYASNE 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209364544  783 FNLEVSILHedQVSDKEHVNHLIVQPPFLQSVHH--PE----SRSSIQHSSVVPSIATVVIIISVCMLVFVVAMGVYRVR 856
Cdd:pfam19699 241 FKVEVNVLH--TANPVEHPNHMAAQPQFVHPVHHafPDlsghNLANPHPSSVVPSAATVVIVVCVSFLVFMIILGVFRIR 318

                         330       340       350
                  ....*....|....*....|....*....|....*.
gi 209364544  857 IAHQHFIQETEAAKESEMDWDDSALTITVNPMEKHE 892
Cdd:pfam19699 319 SAHQRGMRDQEGGKENEMDWDDSALTITVNPMETYE 354
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 165-256 5.04e-13

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 65.80  E-value: 5.04e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209364544 165 YKAVVTEG-KIYDSILQVEAIDEDcSPQYSQIcNYEIVTTDV--PFAIDRN-GNIRNTEKLSYDKQHQYEILVTAYDCGQ 240
Cdd:cd11304    2 YEVSVPENaPPGTVVLTVSATDPD-SGENGEV-TYSIVSGNEdgLFSIDPStGEITTAKPLDREEQSSYTLTVTATDGGG 79

                         90
                 ....*....|....*.
gi 209364544 241 KPAAQDTLVQVDVKPV 256
Cdd:cd11304   80 PPLSSTATVTITVLDV 95
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 47-155 4.64e-12

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 63.10  E-value: 4.64e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209364544  47 SYHGVITENN--DTVILDppLVALDKDAPVPfaGEIcAFKIHGQElPFEAVVLNKTSGEgrLRAKSPIDCELQKEYTFII 124
Cdd:cd11304    1 SYEVSVPENAppGTVVLT--VSATDPDSGEN--GEV-TYSIVSGN-EDGLFSIDPSTGE--ITTAKPLDREEQSSYTLTV 72

                         90       100       110
                 ....*....|....*....|....*....|.
gi 209364544 125 QAYDCGAGPHETawkkshKAVVHIQVKDVNE 155
Cdd:cd11304   73 TATDGGGPPLSS------TATVTITVLDVND 97
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 66-158 6.80e-10

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 56.20  E-value: 6.80e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209364544    66 VALDKDAPVPfaGEIcAFKIHGQElPFEAVVLNKTSGEgrLRAKSPIDCELQKEYTFIIQAYDCGAGPHETawkkshKAV 145
Cdd:smart00112   1 SATDADSGEN--GKV-TYSILSGN-DDGLFSIDPETGE--ITTTKPLDREEQPEYTLTVEATDGGGPPLSS------TAT 68

                           90
                   ....*....|...
gi 209364544   146 VHIQVKDVNEFAP 158
Cdd:smart00112  69 VTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 183-254 5.74e-08

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 50.81  E-value: 5.74e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 209364544   183 AIDEDcSPQYSQIcNYEIV--TTDVPFAIDRN-GNIRNTEKLSYDKQHQYEILVTAYDCGQKPAAQDTLVQVDVK 254
Cdd:smart00112   2 ATDAD-SGENGKV-TYSILsgNDDGLFSIDPEtGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVL 74
Cadherin pfam00028
Cadherin domain;
177-253 5.20e-07

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 48.45  E-value: 5.20e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209364544  177 SILQVEAIDEDCSPQySQIcNYEIVTTDVP--FAIDR-NGNIRNTEKLSYDKQHQYEILVTAYDCGQKPAAQDTLVQVDV 253
Cdd:pfam00028  14 EVLTVTATDPDLGPN-GRI-FYSILGGGPGgnFRIDPdTGDISTTKPLDRESIGEYELTVEATDSGGPPLSSTATVTITV 91
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH