NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|8394006|ref|NP_059060|]
View 

zinc finger protein 260 [Rattus norvegicus]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
21-401 9.03e-10

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 60.09  E-value: 9.03e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394006   21 KVYECDECRKTFSLEQHFVEHKKTHGGEKSPECT--GCGEEFSKASSLTRHLRSR----SRRESYKCGNC---------- 84
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHhnnpSDLNSKSLPLSnskassssls 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394006   85 -GRTFSQRGNFLSHQKQHAEERPSESKktPVPMTTIVRNQRNAGNKPYACKecGKAFNGKSYLKE--------------- 148
Cdd:COG5048 112 sSSSNSNDNNLLSSHSLPPSSRDPQLP--DLLSISNLRNNPLPGNNSSSVN--TPQSNSLHPPLPanslskdpssnlsll 187

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394006  149 -HEKIHTGEKPFECNQCGRAFSQKQYLIKHQNVHSGKKPFKCNECGKAFSQKENLIIHQRIHTGEKPYECKGCGKAFIQK 227
Cdd:COG5048 188 iSSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPT 267

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394006  228 SSLIRHQRSHTGE-------KPYTCKECGKAFSGKSNLTEH--EKIHIGE--KPYKCNE--CGTIFRQKQYLIKHHNIHT 294
Cdd:COG5048 268 ASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHlrSVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHT 347

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394006  295 GEKPYEC-------------NKCGKAFSRITSLIVHVRIHTGDKPYECKVCGKAFCQSSSLTVHMRSHTGEKPygCNECG 361
Cdd:COG5048 348 SISPAKEkllnssskfspllNNEPPQSLQQYKDLKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCK--NPPCS 425

                       410       420       430       440
                ....*....|....*....|....*....|....*....|..
gi 8394006  362 KAFSQFSTLALHMRIHTGEKPYQCSECGKAFSQK--SHHIRH 401
Cdd:COG5048 426 KSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLdlSNHGKD 467
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
21-401 9.03e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 60.09  E-value: 9.03e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394006   21 KVYECDECRKTFSLEQHFVEHKKTHGGEKSPECT--GCGEEFSKASSLTRHLRSR----SRRESYKCGNC---------- 84
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHhnnpSDLNSKSLPLSnskassssls 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394006   85 -GRTFSQRGNFLSHQKQHAEERPSESKktPVPMTTIVRNQRNAGNKPYACKecGKAFNGKSYLKE--------------- 148
Cdd:COG5048 112 sSSSNSNDNNLLSSHSLPPSSRDPQLP--DLLSISNLRNNPLPGNNSSSVN--TPQSNSLHPPLPanslskdpssnlsll 187

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394006  149 -HEKIHTGEKPFECNQCGRAFSQKQYLIKHQNVHSGKKPFKCNECGKAFSQKENLIIHQRIHTGEKPYECKGCGKAFIQK 227
Cdd:COG5048 188 iSSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPT 267

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394006  228 SSLIRHQRSHTGE-------KPYTCKECGKAFSGKSNLTEH--EKIHIGE--KPYKCNE--CGTIFRQKQYLIKHHNIHT 294
Cdd:COG5048 268 ASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHlrSVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHT 347

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394006  295 GEKPYEC-------------NKCGKAFSRITSLIVHVRIHTGDKPYECKVCGKAFCQSSSLTVHMRSHTGEKPygCNECG 361
Cdd:COG5048 348 SISPAKEkllnssskfspllNNEPPQSLQQYKDLKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCK--NPPCS 425

                       410       420       430       440
                ....*....|....*....|....*....|....*....|..
gi 8394006  362 KAFSQFSTLALHMRIHTGEKPYQCSECGKAFSQK--SHHIRH 401
Cdd:COG5048 426 KSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLdlSNHGKD 467
PLN03086 PLN03086
PRLI-interacting factor K; Provisional
 160-293 3.05e-05

PRLI-interacting factor K; Provisional


Pssm-ID: 178635 [Multi-domain]  Cd Length: 567  Bit Score: 46.02  E-value: 3.05e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394006   160 ECNQCGRAFSQKQ------YLIKHQNV--HSG----------KKPFKCNECGKAFSQKEnliIHQRIHTGEKPYECkGCG 221
Cdd:PLN03086 409 ECRNCKHYIPSRSialheaYCSRHNVVcpHDGcgivlrveeaKNHVHCEKCGQAFQQGE---MEKHMKVFHEPLQC-PCG 484

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394006   222 kAFIQKSSLIRHQRSHTGEKPYTCKECGKAFSGKS----------NLTEHEKIhIGEKPYKCNECGtifrqKQYLIKHHN 291
Cdd:PLN03086 485 -VVLEKEQMVQHQASTCPLRLITCRFCGDMVQAGGsamdvrdrlrGMSEHESI-CGSRTAPCDSCG-----RSVMLKEMD 557


                 ..
gi 8394006   292 IH 293
Cdd:PLN03086 558 IH 559
zf-H2C2_2 pfam13465
Zinc-finger double domain;
370-394 2.72e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 2.72e-04
                          10        20
                  ....*....|....*....|....*
gi 8394006    370 LALHMRIHTGEKPYQCSECGKAFSQ 394
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 157-209 8.58e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 37.92  E-value: 8.58e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....
gi 8394006  157 KPFeCNQCGRAFSQKQYLIKHQNvhsgKKPFKCNECGKAFSQKENLIIH-QRIH 209
Cdd:cd20908   1 KPW-CYYCDREFDDEKILIQHQK----AKHFKCHICHKKLYTAGGLAVHcLQVH 49
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
21-401 9.03e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 60.09  E-value: 9.03e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394006   21 KVYECDECRKTFSLEQHFVEHKKTHGGEKSPECT--GCGEEFSKASSLTRHLRSR----SRRESYKCGNC---------- 84
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHhnnpSDLNSKSLPLSnskassssls 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394006   85 -GRTFSQRGNFLSHQKQHAEERPSESKktPVPMTTIVRNQRNAGNKPYACKecGKAFNGKSYLKE--------------- 148
Cdd:COG5048 112 sSSSNSNDNNLLSSHSLPPSSRDPQLP--DLLSISNLRNNPLPGNNSSSVN--TPQSNSLHPPLPanslskdpssnlsll 187

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394006  149 -HEKIHTGEKPFECNQCGRAFSQKQYLIKHQNVHSGKKPFKCNECGKAFSQKENLIIHQRIHTGEKPYECKGCGKAFIQK 227
Cdd:COG5048 188 iSSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPT 267

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394006  228 SSLIRHQRSHTGE-------KPYTCKECGKAFSGKSNLTEH--EKIHIGE--KPYKCNE--CGTIFRQKQYLIKHHNIHT 294
Cdd:COG5048 268 ASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHlrSVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHT 347

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394006  295 GEKPYEC-------------NKCGKAFSRITSLIVHVRIHTGDKPYECKVCGKAFCQSSSLTVHMRSHTGEKPygCNECG 361
Cdd:COG5048 348 SISPAKEkllnssskfspllNNEPPQSLQQYKDLKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCK--NPPCS 425

                       410       420       430       440
                ....*....|....*....|....*....|....*....|..
gi 8394006  362 KAFSQFSTLALHMRIHTGEKPYQCSECGKAFSQK--SHHIRH 401
Cdd:COG5048 426 KSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLdlSNHGKD 467
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
121-407 1.13e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.55  E-value: 1.13e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394006  121 RNQRNAGNKPYACKECGKAFNGKSYLKEHEKIHTGEKPFECNQCGRAFSQKQYLIKHQNV------------------HS 182
Cdd:COG5048  24 LKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLrthhnnpsdlnskslplsNS 103

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394006  183 GKKPFKCNECGKAFSQKENL---------------IIHQRIHTGEKPYE-CKGCGKAFIQKSSLI--------------- 231
Cdd:COG5048 104 KASSSSLSSSSSNSNDNNLLsshslppssrdpqlpDLLSISNLRNNPLPgNNSSSVNTPQSNSLHpplpanslskdpssn 183

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394006  232 ----RHQRSHTGEKPYTCKECGKAFSGKSNLTEHEKIHIGEKPYKCNECGTIF------RQKQYLIKHHNIHTGEKPYEC 301
Cdd:COG5048 184 lsllISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSpksllsQSPSSLSSSDSSSSASESPRS 263

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394006  302 NKCGKAFSRITSLIVHVRIHTG-DKPYECKVCGKAFCQSSSLTVHMRS--HTGE--KPYGCNE--CGKAFSQFSTLALHM 374
Cdd:COG5048 264 SLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHI 343

                       330       340       350
                ....*....|....*....|....*....|....*
gi 8394006  375 RIHTGEKPYQC--SECGKAFSQKSHHIRHQRIHIH 407
Cdd:COG5048 344 LLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQQY 378
PLN03086 PLN03086
PRLI-interacting factor K; Provisional
 160-293 3.05e-05

PRLI-interacting factor K; Provisional


Pssm-ID: 178635 [Multi-domain]  Cd Length: 567  Bit Score: 46.02  E-value: 3.05e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394006   160 ECNQCGRAFSQKQ------YLIKHQNV--HSG----------KKPFKCNECGKAFSQKEnliIHQRIHTGEKPYECkGCG 221
Cdd:PLN03086 409 ECRNCKHYIPSRSialheaYCSRHNVVcpHDGcgivlrveeaKNHVHCEKCGQAFQQGE---MEKHMKVFHEPLQC-PCG 484

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394006   222 kAFIQKSSLIRHQRSHTGEKPYTCKECGKAFSGKS----------NLTEHEKIhIGEKPYKCNECGtifrqKQYLIKHHN 291
Cdd:PLN03086 485 -VVLEKEQMVQHQASTCPLRLITCRFCGDMVQAGGsamdvrdrlrGMSEHESI-CGSRTAPCDSCG-----RSVMLKEMD 557


                 ..
gi 8394006   292 IH 293
Cdd:PLN03086 558 IH 559
zf-H2C2_2 pfam13465
Zinc-finger double domain;
370-394 2.72e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 2.72e-04
                          10        20
                  ....*....|....*....|....*
gi 8394006    370 LALHMRIHTGEKPYQCSECGKAFSQ 394
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
229-253 7.18e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 7.18e-04
                          10        20
                  ....*....|....*....|....*
gi 8394006    229 SLIRHQRSHTGEKPYTCKECGKAFS 253
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
145-170 7.77e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 7.77e-04
                          10        20
                  ....*....|....*....|....*.
gi 8394006    145 YLKEHEKIHTGEKPFECNQCGRAFSQ 170
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 157-209 8.58e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 37.92  E-value: 8.58e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....
gi 8394006  157 KPFeCNQCGRAFSQKQYLIKHQNvhsgKKPFKCNECGKAFSQKENLIIH-QRIH 209
Cdd:cd20908   1 KPW-CYYCDREFDDEKILIQHQK----AKHFKCHICHKKLYTAGGLAVHcLQVH 49
zf-H2C2_2 pfam13465
Zinc-finger double domain;
201-226 3.07e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.07e-03
                          10        20
                  ....*....|....*....|....*.
gi 8394006    201 NLIIHQRIHTGEKPYECKGCGKAFIQ 226
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
313-336 3.63e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 3.63e-03
                          10        20
                  ....*....|....*....|....
gi 8394006    313 SLIVHVRIHTGDKPYECKVCGKAF 336
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 187-209 4.15e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 4.15e-03
                          10        20
                  ....*....|....*....|...
gi 8394006    187 FKCNECGKAFSQKENLIIHQRIH 209
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 215-237 4.95e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 4.95e-03
                          10        20
                  ....*....|....*....|...
gi 8394006    215 YECKGCGKAFIQKSSLIRHQRSH 237
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
341-366 5.07e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 5.07e-03
                          10        20
                  ....*....|....*....|....*.
gi 8394006    341 SLTVHMRSHTGEKPYGCNECGKAFSQ 366
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 327-349 5.52e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 5.52e-03
                          10        20
                  ....*....|....*....|...
gi 8394006    327 YECKVCGKAFCQSSSLTVHMRSH 349
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 121-205 8.05e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 38.16  E-value: 8.05e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394006  121 RNQRNAGNKPYACK--ECGKAFNGKSYLKEHeKIHtgekpfecNQCGRAFSQKQYLIKHQNVHSGKKPFKCNECGKAFSQ 198
Cdd:COG5189 340 RMLKVKDGKPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKN 410


                ....*..
gi 8394006  199 KENLIIH 205
Cdd:COG5189 411 LNGLKYH 417
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH