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Conserved domains on  [gi|8392999|ref|NP_058868|]
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mRNA decay activator protein ZFP36L1 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Tis11B_N pfam04553
Tis11B like protein, N terminus; Members of this family always contain a tandem repeat of CCCH ...
 1-107 1.68e-41

Tis11B like protein, N terminus; Members of this family always contain a tandem repeat of CCCH zinc fingers pfam00642. Tis11B, Tis11D and their homologs are thought to be regulatory proteins involved in the response to growth factors. The function of the N terminus is unknown.


:

Pssm-ID: 461350  Cd Length: 114  Bit Score: 140.77  E-value: 1.68e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392999      1 MTTTLVSAtIFDLsEVLCKGNKMLNystPSAGGC-LLDRKAVGTPAG--GGFPRRHSVTLPSSKFHQNQLLSSLKGEPAP 77
Cdd:pfam04553   1 MSTTLVSA-FFDF-DVLCKNNKSLN---SNPTGLnLLDRKAVGTPVTgsGVFQRRHSVSNLSAKFNQNQFLKELKAEPSS 75

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 8392999     78 TLSS---------RDSRFRDRSFSEGGERLLPTQKQPGS 107
Cdd:pfam04553  76 LISGsggttallnKENKFRDRSFSENGERLLHLQKLQQQ 114
CTH1 super family cl34885
CCCH-type Zn-finger protein [General function prediction only];
115-177 1.26e-12

CCCH-type Zn-finger protein [General function prediction only];


The actual alignment was detected with superfamily member COG5063:

Pssm-ID: 227395 [Multi-domain]  Cd Length: 351  Bit Score: 67.77  E-value: 1.26e-12
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 8392999  115 YKTELCRPFEENGACKYGDKCQFAHGIHELRSLTRHPKYKTELCRTFHTIGFCPYGPRCHFIH 177
Cdd:COG5063 113 YKTEMLRSSTEIPYCRYPDKNPFAHSKAISSLAQTHPKYKTESLEVFINPGYVPYSKRCCFIS 175
 
Name Accession Description Interval E-value
Tis11B_N pfam04553
Tis11B like protein, N terminus; Members of this family always contain a tandem repeat of CCCH ...
 1-107 1.68e-41

Tis11B like protein, N terminus; Members of this family always contain a tandem repeat of CCCH zinc fingers pfam00642. Tis11B, Tis11D and their homologs are thought to be regulatory proteins involved in the response to growth factors. The function of the N terminus is unknown.


Pssm-ID: 461350  Cd Length: 114  Bit Score: 140.77  E-value: 1.68e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392999      1 MTTTLVSAtIFDLsEVLCKGNKMLNystPSAGGC-LLDRKAVGTPAG--GGFPRRHSVTLPSSKFHQNQLLSSLKGEPAP 77
Cdd:pfam04553   1 MSTTLVSA-FFDF-DVLCKNNKSLN---SNPTGLnLLDRKAVGTPVTgsGVFQRRHSVSNLSAKFNQNQFLKELKAEPSS 75

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 8392999     78 TLSS---------RDSRFRDRSFSEGGERLLPTQKQPGS 107
Cdd:pfam04553  76 LISGsggttallnKENKFRDRSFSENGERLLHLQKLQQQ 114
CTH1 COG5063
CCCH-type Zn-finger protein [General function prediction only];
115-177 1.26e-12

CCCH-type Zn-finger protein [General function prediction only];


Pssm-ID: 227395 [Multi-domain]  Cd Length: 351  Bit Score: 67.77  E-value: 1.26e-12
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 8392999  115 YKTELCRPFEENGACKYGDKCQFAHGIHELRSLTRHPKYKTELCRTFHTIGFCPYGPRCHFIH 177
Cdd:COG5063 113 YKTEMLRSSTEIPYCRYPDKNPFAHSKAISSLAQTHPKYKTESLEVFINPGYVPYSKRCCFIS 175
zf-CCCH pfam00642
Zinc finger C-x8-C-x5-C-x3-H type (and similar);
115-140 2.80e-09

Zinc finger C-x8-C-x5-C-x3-H type (and similar);


Pssm-ID: 459885 [Multi-domain]  Cd Length: 27  Bit Score: 51.81  E-value: 2.80e-09
                          10        20
                  ....*....|....*....|....*.
gi 8392999    115 YKTELCRPFEENGACKYGDKCQFAHG 140
Cdd:pfam00642   1 YKTELCRFFLRTGYCKYGDRCKFAHG 26
ZnF_C3H1 smart00356
zinc finger;
114-140 3.40e-07

zinc finger;


Pssm-ID: 214632 [Multi-domain]  Cd Length: 27  Bit Score: 45.70  E-value: 3.40e-07
                           10        20
                   ....*....|....*....|....*..
gi 8392999     114 RYKTELCRPFEeNGACKYGDKCQFAHG 140
Cdd:smart00356   1 KYKTELCKFFK-RGYCPRGDRCKFAHP 26
COG5152 COG5152
Uncharacterized conserved protein, contains RING and CCCH-type Zn-fingers [General function ...
 71-139 6.30e-05

Uncharacterized conserved protein, contains RING and CCCH-type Zn-fingers [General function prediction only];


Pssm-ID: 227481 [Multi-domain]  Cd Length: 259  Bit Score: 43.91  E-value: 6.30e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 8392999   71 LKGEPAPTLS--SRDSRFRD-----RSFSEGGERLLPTQKQPGSGQVNS-SRYKTELCRPFEENGACKYGDKCQFAH 139
Cdd:COG5152  87 LLNFERKELAekAKKRRPSDdnelvLNMSGKNKRLTKQINQPTMFRDGEvIDTQPDVCKDYKETGYCGYGDSCKFLH 163
 
Name Accession Description Interval E-value
Tis11B_N pfam04553
Tis11B like protein, N terminus; Members of this family always contain a tandem repeat of CCCH ...
 1-107 1.68e-41

Tis11B like protein, N terminus; Members of this family always contain a tandem repeat of CCCH zinc fingers pfam00642. Tis11B, Tis11D and their homologs are thought to be regulatory proteins involved in the response to growth factors. The function of the N terminus is unknown.


Pssm-ID: 461350  Cd Length: 114  Bit Score: 140.77  E-value: 1.68e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392999      1 MTTTLVSAtIFDLsEVLCKGNKMLNystPSAGGC-LLDRKAVGTPAG--GGFPRRHSVTLPSSKFHQNQLLSSLKGEPAP 77
Cdd:pfam04553   1 MSTTLVSA-FFDF-DVLCKNNKSLN---SNPTGLnLLDRKAVGTPVTgsGVFQRRHSVSNLSAKFNQNQFLKELKAEPSS 75

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 8392999     78 TLSS---------RDSRFRDRSFSEGGERLLPTQKQPGS 107
Cdd:pfam04553  76 LISGsggttallnKENKFRDRSFSENGERLLHLQKLQQQ 114
CTH1 COG5063
CCCH-type Zn-finger protein [General function prediction only];
115-177 1.26e-12

CCCH-type Zn-finger protein [General function prediction only];


Pssm-ID: 227395 [Multi-domain]  Cd Length: 351  Bit Score: 67.77  E-value: 1.26e-12
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 8392999  115 YKTELCRPFEENGACKYGDKCQFAHGIHELRSLTRHPKYKTELCRTFHTIGFCPYGPRCHFIH 177
Cdd:COG5063 113 YKTEMLRSSTEIPYCRYPDKNPFAHSKAISSLAQTHPKYKTESLEVFINPGYVPYSKRCCFIS 175
CTH1 COG5063
CCCH-type Zn-finger protein [General function prediction only];
58-181 5.12e-10

CCCH-type Zn-finger protein [General function prediction only];


Pssm-ID: 227395 [Multi-domain]  Cd Length: 351  Bit Score: 60.07  E-value: 5.12e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392999   58 PSSKFHQNQLLSSLKGEPAPTLS-SRDSRFRDRSFSEGGE------RLLPTQKQpgsgQVNSSRYKT--ELCRPFEENGA 128
Cdd:COG5063 166 PYSKRCCFISLPLTDINLQPLSQrKPKSGKNCTSYTLGKEsdahphDELIYQKQ----EQNKPLYKTnpELCESFTRKGT 241

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 8392999  129 CKY---GDKCQFA---HGIHELRSLTRHPKYKTELCRTFHTIGFCPYGPRCHFIHNAEE 181
Cdd:COG5063 242 CPYwisGVKCQFAcrgHGLNELKSKKKKQNFRTEPCINWEKSGYCPYGLRCCFKHGDDS 300
CTH1 COG5063
CCCH-type Zn-finger protein [General function prediction only];
91-177 7.99e-10

CCCH-type Zn-finger protein [General function prediction only];


Pssm-ID: 227395 [Multi-domain]  Cd Length: 351  Bit Score: 59.30  E-value: 7.99e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392999   91 FSEGGERLLPTQKQPGSGQVNSSR----YKTELCRPFEENGACKYGDKCQFAHGIHELRSLTRHP--KYKTELCRTFHTI 164
Cdd:COG5063 244 YWISGVKCQFACRGHGLNELKSKKkkqnFRTEPCINWEKSGYCPYGLRCCFKHGDDSDIEMYEEAslGYLDGPCRTRAKG 323

                        90
                ....*....|...
gi 8392999  165 GFCPYGPRCHFIH 177
Cdd:COG5063 324 GAFPSGGAVCKSF 336
zf-CCCH pfam00642
Zinc finger C-x8-C-x5-C-x3-H type (and similar);
115-140 2.80e-09

Zinc finger C-x8-C-x5-C-x3-H type (and similar);


Pssm-ID: 459885 [Multi-domain]  Cd Length: 27  Bit Score: 51.81  E-value: 2.80e-09
                          10        20
                  ....*....|....*....|....*.
gi 8392999    115 YKTELCRPFEENGACKYGDKCQFAHG 140
Cdd:pfam00642   1 YKTELCRFFLRTGYCKYGDRCKFAHG 26
zf-CCCH pfam00642
Zinc finger C-x8-C-x5-C-x3-H type (and similar);
153-177 1.39e-08

Zinc finger C-x8-C-x5-C-x3-H type (and similar);


Pssm-ID: 459885 [Multi-domain]  Cd Length: 27  Bit Score: 49.88  E-value: 1.39e-08
                          10        20
                  ....*....|....*....|....*
gi 8392999    153 YKTELCRTFHTIGFCPYGPRCHFIH 177
Cdd:pfam00642   1 YKTELCRFFLRTGYCKYGDRCKFAH 25
ZnF_C3H1 smart00356
zinc finger;
114-140 3.40e-07

zinc finger;


Pssm-ID: 214632 [Multi-domain]  Cd Length: 27  Bit Score: 45.70  E-value: 3.40e-07
                           10        20
                   ....*....|....*....|....*..
gi 8392999     114 RYKTELCRPFEeNGACKYGDKCQFAHG 140
Cdd:smart00356   1 KYKTELCKFFK-RGYCPRGDRCKFAHP 26
ZnF_C3H1 smart00356
zinc finger;
152-178 3.67e-07

zinc finger;


Pssm-ID: 214632 [Multi-domain]  Cd Length: 27  Bit Score: 45.70  E-value: 3.67e-07
                           10        20
                   ....*....|....*....|....*..
gi 8392999     152 KYKTELCRTFHTiGFCPYGPRCHFIHN 178
Cdd:smart00356   1 KYKTELCKFFKR-GYCPRGDRCKFAHP 26
COG5152 COG5152
Uncharacterized conserved protein, contains RING and CCCH-type Zn-fingers [General function ...
 71-139 6.30e-05

Uncharacterized conserved protein, contains RING and CCCH-type Zn-fingers [General function prediction only];


Pssm-ID: 227481 [Multi-domain]  Cd Length: 259  Bit Score: 43.91  E-value: 6.30e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 8392999   71 LKGEPAPTLS--SRDSRFRD-----RSFSEGGERLLPTQKQPGSGQVNS-SRYKTELCRPFEENGACKYGDKCQFAH 139
Cdd:COG5152  87 LLNFERKELAekAKKRRPSDdnelvLNMSGKNKRLTKQINQPTMFRDGEvIDTQPDVCKDYKETGYCGYGDSCKFLH 163
zf_CCCH_4 pfam18345
Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch ...
 120-139 8.56e-04

Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch domain-containing proteins such as ZIP. Functional studies indicate that ZIP specifically targets EGFR and represses its transcription, and that the zinc finger and the coiled-coil domains are central to that process.


Pssm-ID: 465719 [Multi-domain]  Cd Length: 19  Bit Score: 36.24  E-value: 8.56e-04
                          10        20
                  ....*....|....*....|
gi 8392999    120 CRPFEeNGACKYGDKCQFAH 139
Cdd:pfam18345   1 CKFFL-KGRCRYGDKCRFAH 19
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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