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Conserved domains on  [gi|33620742|ref|NP_057347|]
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fizzy-related protein homolog isoform 2 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
200-472 8.77e-51

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 178.18  E-value: 8.77e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33620742 200 VLSVGLGTCVYLWSACTSQVTRLcdLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAW 279
Cdd:COG2319  93 LASASADGTVRLWDLATGLLLRT--LTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAF 170

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33620742 280 NA--EQLSSGSRDRMILQRDIRTPPLQseRRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAA 357
Cdd:COG2319 171 SPdgKLLASGSDDGTVRLWDLATGKLL--RTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGS 248

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33620742 358 VKAIAWSPHQHgLLASGGgtADRCIRFWNTLTGQPLQCIDT-GSQVCNLAWSKHANELVSthGYSQNQILVWKYPSLTQV 436
Cdd:COG2319 249 VRSVAFSPDGR-LLASGS--ADGTVRLWDLATGELLRTLTGhSGGVNSVAFSPDGKLLAS--GSDDGTVRLWDLATGKLL 323

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 33620742 437 AKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNV 472
Cdd:COG2319 324 RTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDL 359
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
200-472 8.77e-51

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 178.18  E-value: 8.77e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33620742 200 VLSVGLGTCVYLWSACTSQVTRLcdLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAW 279
Cdd:COG2319  93 LASASADGTVRLWDLATGLLLRT--LTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAF 170

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33620742 280 NA--EQLSSGSRDRMILQRDIRTPPLQseRRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAA 357
Cdd:COG2319 171 SPdgKLLASGSDDGTVRLWDLATGKLL--RTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGS 248

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33620742 358 VKAIAWSPHQHgLLASGGgtADRCIRFWNTLTGQPLQCIDT-GSQVCNLAWSKHANELVSthGYSQNQILVWKYPSLTQV 436
Cdd:COG2319 249 VRSVAFSPDGR-LLASGS--ADGTVRLWDLATGELLRTLTGhSGGVNSVAFSPDGKLLAS--GSDDGTVRLWDLATGKLL 323

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 33620742 437 AKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNV 472
Cdd:COG2319 324 RTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDL 359
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 193-471 1.66e-41

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 149.79  E-value: 1.66e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33620742 193 VDWSSLN--VLSVGLGTCVYLWSACTSQVtrLCDLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGH 270
Cdd:cd00200  15 VAFSPDGklLATGSGDGTIKVWDLETGEL--LRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGH 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33620742 271 TARVGALAWNAEQ--LSSGSRDRMILQRDIRTPplQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPV 348
Cdd:cd00200  93 TSYVSSVAFSPDGriLSSSSRDKTIKVWDVETG--KCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCV 170

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33620742 349 QQYTEHLAAVKAIAWSPHQHGLLASGGgtaDRCIRFWNTLTGQPLQCIDT-GSQVCNLAWSKHANELVSthGYSQNQILV 427
Cdd:cd00200 171 ATLTGHTGEVNSVAFSPDGEKLLSSSS---DGTIKLWDLSTGKCLGTLRGhENGVNSVAFSPDGYLLAS--GSEDGTIRV 245

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 33620742 428 WKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWN 471
Cdd:cd00200 246 WDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 302-341 1.05e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.38  E-value: 1.05e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 33620742    302 PLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWN 341
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 296-482 3.35e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 49.70  E-value: 3.35e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33620742  296 RDIRTPPLQserrLQGhRQEVCGLKW-STDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASg 374
Cdd:PLN00181 520 RDIHYPVVE----LAS-RSKLSGICWnSYIKSQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLAS- 593

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33620742  375 gGTADRCIRFWNTLTGQPLQCIDTGSQVCNLAWSKHANELVStHGYSQNQILVW--KYPSLTqVAKLTGHSYRVLYLAMS 452
Cdd:PLN00181 594 -GSDDGSVKLWSINQGVSIGTIKTKANICCVQFPSESGRSLA-FGSADHKVYYYdlRNPKLP-LCTMIGHSKTVSYVRFV 670

                        170       180       190
                 ....*....|....*....|....*....|
gi 33620742  453 pDGEAIVTGAGDETLRFWNVFSKTRSTKES 482
Cdd:PLN00181 671 -DSSTLVSSSTDNTLKLWDLSMSISGINET 699
WD40 pfam00400
WD domain, G-beta repeat;
304-341 1.01e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.33  E-value: 1.01e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 33620742   304 QSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWN 341
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
200-472 8.77e-51

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 178.18  E-value: 8.77e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33620742 200 VLSVGLGTCVYLWSACTSQVTRLcdLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAW 279
Cdd:COG2319  93 LASASADGTVRLWDLATGLLLRT--LTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAF 170

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33620742 280 NA--EQLSSGSRDRMILQRDIRTPPLQseRRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAA 357
Cdd:COG2319 171 SPdgKLLASGSDDGTVRLWDLATGKLL--RTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGS 248

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33620742 358 VKAIAWSPHQHgLLASGGgtADRCIRFWNTLTGQPLQCIDT-GSQVCNLAWSKHANELVSthGYSQNQILVWKYPSLTQV 436
Cdd:COG2319 249 VRSVAFSPDGR-LLASGS--ADGTVRLWDLATGELLRTLTGhSGGVNSVAFSPDGKLLAS--GSDDGTVRLWDLATGKLL 323

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 33620742 437 AKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNV 472
Cdd:COG2319 324 RTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDL 359
WD40 COG2319
WD40 repeat [General function prediction only];
209-472 4.19e-47

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 168.17  E-value: 4.19e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33620742 209 VYLWSACTSQVTRlcDLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWNA--EQLSS 286
Cdd:COG2319 144 VRLWDLATGKLLR--TLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPdgKLLAS 221

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33620742 287 GSRDRMILQRDIRTPPLQseRRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPH 366
Cdd:COG2319 222 GSADGTVRLWDLATGKLL--RTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPD 299

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33620742 367 QHgLLASGGgtADRCIRFWNTLTGQPLQCID-TGSQVCNLAWSKHANELVSthGYSQNQILVWKYPSLTQVAKLTGHSYR 445
Cdd:COG2319 300 GK-LLASGS--DDGTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKTLAS--GSDDGTVRLWDLATGELLRTLTGHTGA 374

                       250       260
                ....*....|....*....|....*..
gi 33620742 446 VLYLAMSPDGEAIVTGAGDETLRFWNV 472
Cdd:COG2319 375 VTSVAFSPDGRTLASGSADGTVRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
225-472 1.75e-43

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 158.54  E-value: 1.75e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33620742 225 LSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAW--NAEQLSSGSRDRMILQRDIRTPP 302
Cdd:COG2319  74 LLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFspDGKTLASGSADGTVRLWDLATGK 153

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33620742 303 LQseRRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHgLLASGGgtADRCI 382
Cdd:COG2319 154 LL--RTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGK-LLASGS--ADGTV 228

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33620742 383 RFWNTLTGQPLQCIDT-GSQVCNLAWSKHANELVSthGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTG 461
Cdd:COG2319 229 RLWDLATGKLLRTLTGhSGSVRSVAFSPDGRLLAS--GSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASG 306

                       250
                ....*....|.
gi 33620742 462 AGDETLRFWNV 472
Cdd:COG2319 307 SDDGTVRLWDL 317
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 193-471 1.66e-41

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 149.79  E-value: 1.66e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33620742 193 VDWSSLN--VLSVGLGTCVYLWSACTSQVtrLCDLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGH 270
Cdd:cd00200  15 VAFSPDGklLATGSGDGTIKVWDLETGEL--LRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGH 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33620742 271 TARVGALAWNAEQ--LSSGSRDRMILQRDIRTPplQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPV 348
Cdd:cd00200  93 TSYVSSVAFSPDGriLSSSSRDKTIKVWDVETG--KCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCV 170

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33620742 349 QQYTEHLAAVKAIAWSPHQHGLLASGGgtaDRCIRFWNTLTGQPLQCIDT-GSQVCNLAWSKHANELVSthGYSQNQILV 427
Cdd:cd00200 171 ATLTGHTGEVNSVAFSPDGEKLLSSSS---DGTIKLWDLSTGKCLGTLRGhENGVNSVAFSPDGYLLAS--GSEDGTIRV 245

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 33620742 428 WKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWN 471
Cdd:cd00200 246 WDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 230-472 5.54e-38

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 140.55  E-value: 5.54e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33620742 230 DSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAW--NAEQLSSGSRDRMILQRDIRTPplQSER 307
Cdd:cd00200  10 GGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAAsaDGTYLASGSSDKTIRLWDLETG--ECVR 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33620742 308 RLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHgLLASGGgtADRCIRFWNT 387
Cdd:cd00200  88 TLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGT-FVASSS--QDGTIKLWDL 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33620742 388 LTGQPLQCIdTG--SQVCNLAWSKHANELVSthGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDE 465
Cdd:cd00200 165 RTGKCVATL-TGhtGEVNSVAFSPDGEKLLS--SSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDG 241


                ....*..
gi 33620742 466 TLRFWNV 472
Cdd:cd00200 242 TIRVWDL 248
WD40 COG2319
WD40 repeat [General function prediction only];
211-472 4.78e-35

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 135.42  E-value: 4.78e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33620742 211 LWSACTSQVTRLCDLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAW--NAEQLSSGS 288
Cdd:COG2319  18 LALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFspDGRLLASAS 97

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33620742 289 RDRMILQRDIRTPPLQseRRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQH 368
Cdd:COG2319  98 ADGTVRLWDLATGLLL--RTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGK 175

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33620742 369 gLLASGGgtADRCIRFWNTLTGQPLQCID-TGSQVCNLAWSKHANELVSthGYSQNQILVWKYPSLTQVAKLTGHSYRVL 447
Cdd:COG2319 176 -LLASGS--DDGTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKLLAS--GSADGTVRLWDLATGKLLRTLTGHSGSVR 250

                       250       260
                ....*....|....*....|....*
gi 33620742 448 YLAMSPDGEAIVTGAGDETLRFWNV 472
Cdd:COG2319 251 SVAFSPDGRLLASGSADGTVRLWDL 275
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 267-472 4.62e-34

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 129.76  E-value: 4.62e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33620742 267 LEGHTARVGALAWNAEQ--LSSGSRDRMILQRDIRTPplQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSS 344
Cdd:cd00200   5 LKGHTGGVTCVAFSPDGklLATGSGDGTIKVWDLETG--ELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLET 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33620742 345 LSPVQQYTEHLAAVKAIAWSPHQHgLLASGGgtADRCIRFWNTLTGQPLQCIDT-GSQVCNLAWSkHANELVSThGYSQN 423
Cdd:cd00200  83 GECVRTLTGHTSYVSSVAFSPDGR-ILSSSS--RDKTIKVWDVETGKCLTTLRGhTDWVNSVAFS-PDGTFVAS-SSQDG 157

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 33620742 424 QILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNV 472
Cdd:cd00200 158 TIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDL 206
WD40 COG2319
WD40 repeat [General function prediction only];
236-472 2.45e-29

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 119.25  E-value: 2.45e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33620742 236 GWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWNAEQLSSGSRDRMILQRDIRTPPLQSERRLQGHRQE 315
Cdd:COG2319   1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33620742 316 VCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHgLLASGGgtADRCIRFWNTLTGQPLQC 395
Cdd:COG2319  81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGK-TLASGS--ADGTVRLWDLATGKLLRT 157

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 33620742 396 IDTGSQ-VCNLAWSKHANELVSthGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNV 472
Cdd:COG2319 158 LTGHSGaVTSVAFSPDGKLLAS--GSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDL 233
WD40 COG2319
WD40 repeat [General function prediction only];
200-387 2.84e-29

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 118.86  E-value: 2.84e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33620742 200 VLSVGLGTCVYLWSActSQVTRLCDLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAW 279
Cdd:COG2319 219 LASGSADGTVRLWDL--ATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAF 296

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33620742 280 --NAEQLSSGSRDRMILQRDIRTPPLQseRRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAA 357
Cdd:COG2319 297 spDGKLLASGSDDGTVRLWDLATGKLL--RTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGA 374

                       170       180       190
                ....*....|....*....|....*....|
gi 33620742 358 VKAIAWSPHQHgLLASGGgtADRCIRFWNT 387
Cdd:COG2319 375 VTSVAFSPDGR-TLASGS--ADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 305-472 7.31e-26

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 107.04  E-value: 7.31e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33620742 305 SERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHgLLASGGGtaDRCIRF 384
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGT-YLASGSS--DKTIRL 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33620742 385 WNTLTGQPLQCIdTG--SQVCNLAWSKHaNELVSThGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGA 462
Cdd:cd00200  78 WDLETGECVRTL-TGhtSYVSSVAFSPD-GRILSS-SSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSS 154

                       170
                ....*....|
gi 33620742 463 GDETLRFWNV 472
Cdd:cd00200 155 QDGTIKLWDL 164
WD40 COG2319
WD40 repeat [General function prediction only];
322-474 3.51e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 61.85  E-value: 3.51e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33620742 322 STDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRciRFWNTLTGQPLQCIDTGSQ 401
Cdd:COG2319   3 SADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLL--LLDAAAGALLATLLGHTAA 80

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 33620742 402 VCNLAWSKHANELVSthGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNVFS 474
Cdd:COG2319  81 VLSVAFSPDGRLLAS--ASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLAT 151
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 302-341 1.05e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.38  E-value: 1.05e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 33620742    302 PLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWN 341
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 296-482 3.35e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 49.70  E-value: 3.35e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33620742  296 RDIRTPPLQserrLQGhRQEVCGLKW-STDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASg 374
Cdd:PLN00181 520 RDIHYPVVE----LAS-RSKLSGICWnSYIKSQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLAS- 593

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33620742  375 gGTADRCIRFWNTLTGQPLQCIDTGSQVCNLAWSKHANELVStHGYSQNQILVW--KYPSLTqVAKLTGHSYRVLYLAMS 452
Cdd:PLN00181 594 -GSDDGSVKLWSINQGVSIGTIKTKANICCVQFPSESGRSLA-FGSADHKVYYYdlRNPKLP-LCTMIGHSKTVSYVRFV 670

                        170       180       190
                 ....*....|....*....|....*....|
gi 33620742  453 pDGEAIVTGAGDETLRFWNVFSKTRSTKES 482
Cdd:PLN00181 671 -DSSTLVSSSTDNTLKLWDLSMSISGINET 699
WD40 pfam00400
WD domain, G-beta repeat;
304-341 1.01e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.33  E-value: 1.01e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 33620742   304 QSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWN 341
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 432-471 2.32e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.53  E-value: 2.32e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 33620742    432 SLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWN 471
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
434-471 7.44e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.02  E-value: 7.44e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 33620742   434 TQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWN 471
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 344-386 1.43e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.22  E-value: 1.43e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 33620742    344 SLSPVQQYTEHLAAVKAIAWSPHQHgLLASGGgtADRCIRFWN 386
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGK-YLASGS--DDGTIKLWD 40
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 228-280 1.15e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 38.03  E-value: 1.15e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 33620742   228 EGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWN 280
Cdd:pfam12894  37 EDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLITCLGWG 89
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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