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Conserved domains on  [gi|730229393|ref|NP_056484|]
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protocadherin beta-5 precursor [Homo sapiens]

Protein Classification

protocadherin( domain architecture ID 11175748)

protocadherin may have tightly regulated functions in the development, regionalization, and functional differentiation of the central nervous system

CATH:  2.60.40.60
Gene Ontology:  GO:0007156|GO:0005509
PubMed:  28268172|18430161
SCOP:  4007535

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 30-112 1.87e-43

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


:

Pssm-ID: 462413  Cd Length: 83  Bit Score: 151.53  E-value: 1.87e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 730229393   30 AVRYSIPEETESGYSVANLAKDLGLGVGELATRGARMHYKGNKELLQLDIKTGNLLLYEKLDREVMCGATEPCILHFQLL 109
Cdd:pfam08266   1 QIRYSVPEETERGSFVGNLAKDLGLEVGELAARGARVVSKGNKQYFQLNPETGDLLLNEKLDREELCGSTEPCVLHFQVL 80


                  ...
gi 730229393  110 LEN 112
Cdd:pfam08266  81 LEN 83
Cadherin_C_2 pfam16492
Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some ...
 684-767 4.47e-33

Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some proto-cadherins. It is this region of the cadherins that allows cell-adhesion and the essential feature of metazoan multicellularity. Cadherins are cell-surface receptors that function in cell adhesion, cell polarity, and tissue morphogenesis.


:

Pssm-ID: 465139  Cd Length: 84  Bit Score: 122.25  E-value: 4.47e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 730229393  684 SLTVYLVVALASVSSLFLFSVLLFVAVRLCRRSRAAPVGR----CSVPEGPFPGHlvdvSGTGTLSQSYHYEVCLTGDSG 759
Cdd:pfam16492   1 DLTFYLVIALASVSFLFLLFVIVLIALRLRRWRSSALLQSsgnlCSVPAPHFPGN----DGTGTLPQSYSYEVCLTSDSG 76


                  ....*...
gi 730229393  760 AGEFKFLK 767
Cdd:pfam16492  77 KSEFKFLK 84
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 247-342 2.94e-31

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 117.41  E-value: 2.94e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 730229393 247 YEVQVPENSPLNSLVVVVSARDLDAGAYGSVAYALFQGDEvTQPFVIDEKTAEIRLKRALDFEATPYYNVEIVATDGGG- 325
Cdd:cd11304    2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNE-DGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGp 80

                         90
                 ....*....|....*...
gi 730229393 326 -LSGKCTVAIEVVDVNDN 342
Cdd:cd11304   81 pLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 454-556 2.97e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 114.72  E-value: 2.97e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 730229393 454 SYTLFVRENNSPALHIGSVSATDRDSGTNAQVTYSLLPPQNPHLrlaslVSINADNGHLFALRSLDYEALQAFEFRVGAT 533
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGL-----FSIDPSTGEITTAKPLDREEQSSYTLTVTAT 75

                         90       100
                 ....*....|....*....|...
gi 730229393 534 DRGSPALSSEALVRVLVLDANDN 556
Cdd:cd11304   76 DGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 356-446 2.21e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 95.07  E-value: 2.21e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 730229393 356 PENAPE-TVVAVFSVSDPDSGDNGRMICSIQN---DLPFLLKPtlkNFYTLVTQRTLDRESQAEYNITITVTDMGTPRLK 431
Cdd:cd11304    7 PENAPPgTVVLTVSATDPDSGENGEVTYSIVSgneDGLFSIDP---STGEITTAKPLDREEQSSYTLTVTATDGGGPPLS 83

                         90
                 ....*....|....*
gi 730229393 432 TEHNITVLVSDVNDN 446
Cdd:cd11304   84 STATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 575-663 7.23e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 93.53  E-value: 7.23e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 730229393 575 VPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATEPGLFSMWAHNGEVRTARLLSERDAAKHRLVVLVKDNGEPPRSAT 654
Cdd:cd11304    6 VPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLSST 85


                 ....*....
gi 730229393 655 ATLHVLLVD 663
Cdd:cd11304   86 ATVTITVLD 94
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 140-238 2.25e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 92.38  E-value: 2.25e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 730229393 140 LKIPESTQPGTVFPLKIAQDFDIGSNTVQNYTIS---PNSHFHVathNRGDGrkypELVLDKALDREERPELSLTLTALD 216
Cdd:cd11304    4 VSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsgnEDGLFSI---DPSTG----EITTAKPLDREEQSSYTLTVTATD 76

                         90       100
                 ....*....|....*....|..
gi 730229393 217 GGAPPRSGTTTIRIVVLDNNDN 238
Cdd:cd11304   77 GGGPPLSSTATVTITVLDVNDN 98
 
Name Accession Description Interval E-value
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 30-112 1.87e-43

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


Pssm-ID: 462413  Cd Length: 83  Bit Score: 151.53  E-value: 1.87e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 730229393   30 AVRYSIPEETESGYSVANLAKDLGLGVGELATRGARMHYKGNKELLQLDIKTGNLLLYEKLDREVMCGATEPCILHFQLL 109
Cdd:pfam08266   1 QIRYSVPEETERGSFVGNLAKDLGLEVGELAARGARVVSKGNKQYFQLNPETGDLLLNEKLDREELCGSTEPCVLHFQVL 80


                  ...
gi 730229393  110 LEN 112
Cdd:pfam08266  81 LEN 83
Cadherin_C_2 pfam16492
Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some ...
 684-767 4.47e-33

Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some proto-cadherins. It is this region of the cadherins that allows cell-adhesion and the essential feature of metazoan multicellularity. Cadherins are cell-surface receptors that function in cell adhesion, cell polarity, and tissue morphogenesis.


Pssm-ID: 465139  Cd Length: 84  Bit Score: 122.25  E-value: 4.47e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 730229393  684 SLTVYLVVALASVSSLFLFSVLLFVAVRLCRRSRAAPVGR----CSVPEGPFPGHlvdvSGTGTLSQSYHYEVCLTGDSG 759
Cdd:pfam16492   1 DLTFYLVIALASVSFLFLLFVIVLIALRLRRWRSSALLQSsgnlCSVPAPHFPGN----DGTGTLPQSYSYEVCLTSDSG 76


                  ....*...
gi 730229393  760 AGEFKFLK 767
Cdd:pfam16492  77 KSEFKFLK 84
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 247-342 2.94e-31

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 117.41  E-value: 2.94e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 730229393 247 YEVQVPENSPLNSLVVVVSARDLDAGAYGSVAYALFQGDEvTQPFVIDEKTAEIRLKRALDFEATPYYNVEIVATDGGG- 325
Cdd:cd11304    2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNE-DGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGp 80

                         90
                 ....*....|....*...
gi 730229393 326 -LSGKCTVAIEVVDVNDN 342
Cdd:cd11304   81 pLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 454-556 2.97e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 114.72  E-value: 2.97e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 730229393 454 SYTLFVRENNSPALHIGSVSATDRDSGTNAQVTYSLLPPQNPHLrlaslVSINADNGHLFALRSLDYEALQAFEFRVGAT 533
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGL-----FSIDPSTGEITTAKPLDREEQSSYTLTVTAT 75

                         90       100
                 ....*....|....*....|...
gi 730229393 534 DRGSPALSSEALVRVLVLDANDN 556
Cdd:cd11304   76 DGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 356-446 2.21e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 95.07  E-value: 2.21e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 730229393 356 PENAPE-TVVAVFSVSDPDSGDNGRMICSIQN---DLPFLLKPtlkNFYTLVTQRTLDRESQAEYNITITVTDMGTPRLK 431
Cdd:cd11304    7 PENAPPgTVVLTVSATDPDSGENGEVTYSIVSgneDGLFSIDP---STGEITTAKPLDREEQSSYTLTVTATDGGGPPLS 83

                         90
                 ....*....|....*
gi 730229393 432 TEHNITVLVSDVNDN 446
Cdd:cd11304   84 STATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 473-558 2.48e-23

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 94.34  E-value: 2.48e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 730229393   473 SATDRDSGTNAQVTYSLLPPQNPHLrlaslVSINADNGHLFALRSLDYEALQAFEFRVGATDRGSPALSSEALVRVLVLD 552
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDDGL-----FSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLD 75


                   ....*.
gi 730229393   553 ANDNSP 558
Cdd:smart00112  76 VNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 575-663 7.23e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 93.53  E-value: 7.23e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 730229393 575 VPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATEPGLFSMWAHNGEVRTARLLSERDAAKHRLVVLVKDNGEPPRSAT 654
Cdd:cd11304    6 VPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLSST 85


                 ....*....
gi 730229393 655 ATLHVLLVD 663
Cdd:cd11304   86 ATVTITVLD 94
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 140-238 2.25e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 92.38  E-value: 2.25e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 730229393 140 LKIPESTQPGTVFPLKIAQDFDIGSNTVQNYTIS---PNSHFHVathNRGDGrkypELVLDKALDREERPELSLTLTALD 216
Cdd:cd11304    4 VSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsgnEDGLFSI---DPSTG----EITTAKPLDREEQSSYTLTVTATD 76

                         90       100
                 ....*....|....*....|..
gi 730229393 217 GGAPPRSGTTTIRIVVLDNNDN 238
Cdd:cd11304   77 GGGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 265-344 2.74e-22

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 91.26  E-value: 2.74e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 730229393   265 SARDLDAGAYGSVAYALFQGDEvTQPFVIDEKTAEIRLKRALDFEATPYYNVEIVATDGGG--LSGKCTVAIEVVDVNDN 342
Cdd:smart00112   1 SATDADSGENGKVTYSILSGND-DGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGppLSSTATVTITVLDVNDN 79


                   ..
gi 730229393   343 AP 344
Cdd:smart00112  80 AP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 157-240 3.73e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 85.09  E-value: 3.73e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 730229393   157 AQDFDIGSNTVQNYTISPNSHFHVATHNRGDGrkypELVLDKALDREERPELSLTLTALDGGAPPRSGTTTIRIVVLDNN 236
Cdd:smart00112   2 ATDADSGENGKVTYSILSGNDDGLFSIDPETG----EITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                   ....
gi 730229393   237 DNAP 240
Cdd:smart00112  78 DNAP 81
Cadherin pfam00028
Cadherin domain;
247-336 2.39e-19

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 83.50  E-value: 2.39e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 730229393  247 YEVQVPENSPLNSLVVVVSARDLDAGAYGSVAYALfQGDEVTQPFVIDEKTAEIRLKRALDFEATPYYNVEIVATDGG-- 324
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSI-LGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGgp 79

                          90
                  ....*....|..
gi 730229393  325 GLSGKCTVAIEV 336
Cdd:pfam00028  80 PLSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
455-551 5.68e-19

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 82.35  E-value: 5.68e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 730229393  455 YTLFVRENNSPALHIGSVSATDRDSGTNAQVTYSLLPPQNPHLrlaslVSINADNGHLFALRSLDYEALQAFEFRVGATD 534
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGN-----FRIDPDTGDISTTKPLDRESIGEYELTVEATD 75

                          90
                  ....*....|....*..
gi 730229393  535 RGSPALSSEALVRVLVL 551
Cdd:pfam00028  76 SGGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 368-448 1.02e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 81.24  E-value: 1.02e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 730229393   368 SVSDPDSGDNGRMICSIQ---NDLPFLLKPTLKnfyTLVTQRTLDRESQAEYNITITVTDMGTPRLKTEHNITVLVSDVN 444
Cdd:smart00112   1 SATDADSGENGKVTYSILsgnDDGLFSIDPETG---EITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                   ....
gi 730229393   445 DNAP 448
Cdd:smart00112  78 DNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 589-663 2.99e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 74.31  E-value: 2.99e-16
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 730229393   589 VAVDGDSGQNAWLSYQLLKATEPGLFSMWAHNGEVRTARLLSERDAAKHRLVVLVKDNGEPPRSATATLHVLLVD 663
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLD 75
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 33-129 5.92e-15

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 71.22  E-value: 5.92e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 730229393  33 YSIPEETESGYSVANLAKDLGlgvgELATRGARMHYKGNK---ELLQLDIKTGNLLLYEKLDREvmcgatEPCILHFQLL 109
Cdd:cd00031    4 GSAVEGRSRGSFRVSIPTDLI----ASSGEIIKISAAGKEalpSWLHWEPHSGILEGLEKLDRE------DKGVHYISVS 73

                         90       100
                 ....*....|....*....|....*
gi 730229393 110 L-----ENPVQFFQTDLQLTDINDH 129
Cdd:cd00031   74 AaslgaNVPQTSSVFSIEVYDENDN 98
Cadherin pfam00028
Cadherin domain;
575-661 4.59e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 65.40  E-value: 4.59e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 730229393  575 VPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATEPGLFSMWAHNGEVRTARLLSERDAAKHRLVVLVKDNGEPPRSAT 654
Cdd:pfam00028   5 VPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLSST 84


                  ....*..
gi 730229393  655 ATLHVLL 661
Cdd:pfam00028  85 ATVTITV 91
Cadherin pfam00028
Cadherin domain;
142-233 1.94e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 63.86  E-value: 1.94e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 730229393  142 IPESTQPGTvFPLKI-AQDFDIGSNTVQNYTIS---PNSHFHVATHNRgdgrkypELVLDKALDREERPELSLTLTALDG 217
Cdd:pfam00028   5 VPENAPVGT-EVLTVtATDPDLGPNGRIFYSILgggPGGNFRIDPDTG-------DISTTKPLDRESIGEYELTVEATDS 76

                          90
                  ....*....|....*.
gi 730229393  218 GAPPRSGTTTIRIVVL 233
Cdd:pfam00028  77 GGPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
356-440 4.07e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 62.70  E-value: 4.07e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 730229393  356 PENAPE-TVVAVFSVSDPDSGDNGRMICSIQNDLPFllkptlKNFY------TLVTQRTLDRESQAEYNITITVTDMGTP 428
Cdd:pfam00028   6 PENAPVgTEVLTVTATDPDLGPNGRIFYSILGGGPG------GNFRidpdtgDISTTKPLDRESIGEYELTVEATDSGGP 79

                          90
                  ....*....|..
gi 730229393  429 RLKTEHNITVLV 440
Cdd:pfam00028  80 PLSSTATVTITV 91
 
Name Accession Description Interval E-value
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 30-112 1.87e-43

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


Pssm-ID: 462413  Cd Length: 83  Bit Score: 151.53  E-value: 1.87e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 730229393   30 AVRYSIPEETESGYSVANLAKDLGLGVGELATRGARMHYKGNKELLQLDIKTGNLLLYEKLDREVMCGATEPCILHFQLL 109
Cdd:pfam08266   1 QIRYSVPEETERGSFVGNLAKDLGLEVGELAARGARVVSKGNKQYFQLNPETGDLLLNEKLDREELCGSTEPCVLHFQVL 80


                  ...
gi 730229393  110 LEN 112
Cdd:pfam08266  81 LEN 83
Cadherin_C_2 pfam16492
Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some ...
 684-767 4.47e-33

Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some proto-cadherins. It is this region of the cadherins that allows cell-adhesion and the essential feature of metazoan multicellularity. Cadherins are cell-surface receptors that function in cell adhesion, cell polarity, and tissue morphogenesis.


Pssm-ID: 465139  Cd Length: 84  Bit Score: 122.25  E-value: 4.47e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 730229393  684 SLTVYLVVALASVSSLFLFSVLLFVAVRLCRRSRAAPVGR----CSVPEGPFPGHlvdvSGTGTLSQSYHYEVCLTGDSG 759
Cdd:pfam16492   1 DLTFYLVIALASVSFLFLLFVIVLIALRLRRWRSSALLQSsgnlCSVPAPHFPGN----DGTGTLPQSYSYEVCLTSDSG 76


                  ....*...
gi 730229393  760 AGEFKFLK 767
Cdd:pfam16492  77 KSEFKFLK 84
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 247-342 2.94e-31

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 117.41  E-value: 2.94e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 730229393 247 YEVQVPENSPLNSLVVVVSARDLDAGAYGSVAYALFQGDEvTQPFVIDEKTAEIRLKRALDFEATPYYNVEIVATDGGG- 325
Cdd:cd11304    2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNE-DGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGp 80

                         90
                 ....*....|....*...
gi 730229393 326 -LSGKCTVAIEVVDVNDN 342
Cdd:cd11304   81 pLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 454-556 2.97e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 114.72  E-value: 2.97e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 730229393 454 SYTLFVRENNSPALHIGSVSATDRDSGTNAQVTYSLLPPQNPHLrlaslVSINADNGHLFALRSLDYEALQAFEFRVGAT 533
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGL-----FSIDPSTGEITTAKPLDREEQSSYTLTVTAT 75

                         90       100
                 ....*....|....*....|...
gi 730229393 534 DRGSPALSSEALVRVLVLDANDN 556
Cdd:cd11304   76 DGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 356-446 2.21e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 95.07  E-value: 2.21e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 730229393 356 PENAPE-TVVAVFSVSDPDSGDNGRMICSIQN---DLPFLLKPtlkNFYTLVTQRTLDRESQAEYNITITVTDMGTPRLK 431
Cdd:cd11304    7 PENAPPgTVVLTVSATDPDSGENGEVTYSIVSgneDGLFSIDP---STGEITTAKPLDREEQSSYTLTVTATDGGGPPLS 83

                         90
                 ....*....|....*
gi 730229393 432 TEHNITVLVSDVNDN 446
Cdd:cd11304   84 STATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 473-558 2.48e-23

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 94.34  E-value: 2.48e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 730229393   473 SATDRDSGTNAQVTYSLLPPQNPHLrlaslVSINADNGHLFALRSLDYEALQAFEFRVGATDRGSPALSSEALVRVLVLD 552
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDDGL-----FSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLD 75


                   ....*.
gi 730229393   553 ANDNSP 558
Cdd:smart00112  76 VNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 575-663 7.23e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 93.53  E-value: 7.23e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 730229393 575 VPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATEPGLFSMWAHNGEVRTARLLSERDAAKHRLVVLVKDNGEPPRSAT 654
Cdd:cd11304    6 VPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLSST 85


                 ....*....
gi 730229393 655 ATLHVLLVD 663
Cdd:cd11304   86 ATVTITVLD 94
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 140-238 2.25e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 92.38  E-value: 2.25e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 730229393 140 LKIPESTQPGTVFPLKIAQDFDIGSNTVQNYTIS---PNSHFHVathNRGDGrkypELVLDKALDREERPELSLTLTALD 216
Cdd:cd11304    4 VSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsgnEDGLFSI---DPSTG----EITTAKPLDREEQSSYTLTVTATD 76

                         90       100
                 ....*....|....*....|..
gi 730229393 217 GGAPPRSGTTTIRIVVLDNNDN 238
Cdd:cd11304   77 GGGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 265-344 2.74e-22

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 91.26  E-value: 2.74e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 730229393   265 SARDLDAGAYGSVAYALFQGDEvTQPFVIDEKTAEIRLKRALDFEATPYYNVEIVATDGGG--LSGKCTVAIEVVDVNDN 342
Cdd:smart00112   1 SATDADSGENGKVTYSILSGND-DGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGppLSSTATVTITVLDVNDN 79


                   ..
gi 730229393   343 AP 344
Cdd:smart00112  80 AP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 157-240 3.73e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 85.09  E-value: 3.73e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 730229393   157 AQDFDIGSNTVQNYTISPNSHFHVATHNRGDGrkypELVLDKALDREERPELSLTLTALDGGAPPRSGTTTIRIVVLDNN 236
Cdd:smart00112   2 ATDADSGENGKVTYSILSGNDDGLFSIDPETG----EITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                   ....
gi 730229393   237 DNAP 240
Cdd:smart00112  78 DNAP 81
Cadherin pfam00028
Cadherin domain;
247-336 2.39e-19

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 83.50  E-value: 2.39e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 730229393  247 YEVQVPENSPLNSLVVVVSARDLDAGAYGSVAYALfQGDEVTQPFVIDEKTAEIRLKRALDFEATPYYNVEIVATDGG-- 324
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSI-LGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGgp 79

                          90
                  ....*....|..
gi 730229393  325 GLSGKCTVAIEV 336
Cdd:pfam00028  80 PLSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
455-551 5.68e-19

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 82.35  E-value: 5.68e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 730229393  455 YTLFVRENNSPALHIGSVSATDRDSGTNAQVTYSLLPPQNPHLrlaslVSINADNGHLFALRSLDYEALQAFEFRVGATD 534
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGN-----FRIDPDTGDISTTKPLDRESIGEYELTVEATD 75

                          90
                  ....*....|....*..
gi 730229393  535 RGSPALSSEALVRVLVL 551
Cdd:pfam00028  76 SGGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 368-448 1.02e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 81.24  E-value: 1.02e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 730229393   368 SVSDPDSGDNGRMICSIQ---NDLPFLLKPTLKnfyTLVTQRTLDRESQAEYNITITVTDMGTPRLKTEHNITVLVSDVN 444
Cdd:smart00112   1 SATDADSGENGKVTYSILsgnDDGLFSIDPETG---EITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                   ....
gi 730229393   445 DNAP 448
Cdd:smart00112  78 DNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 589-663 2.99e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 74.31  E-value: 2.99e-16
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 730229393   589 VAVDGDSGQNAWLSYQLLKATEPGLFSMWAHNGEVRTARLLSERDAAKHRLVVLVKDNGEPPRSATATLHVLLVD 663
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLD 75
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 33-129 5.92e-15

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 71.22  E-value: 5.92e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 730229393  33 YSIPEETESGYSVANLAKDLGlgvgELATRGARMHYKGNK---ELLQLDIKTGNLLLYEKLDREvmcgatEPCILHFQLL 109
Cdd:cd00031    4 GSAVEGRSRGSFRVSIPTDLI----ASSGEIIKISAAGKEalpSWLHWEPHSGILEGLEKLDRE------DKGVHYISVS 73

                         90       100
                 ....*....|....*....|....*
gi 730229393 110 L-----ENPVQFFQTDLQLTDINDH 129
Cdd:cd00031   74 AaslgaNVPQTSSVFSIEVYDENDN 98
Cadherin pfam00028
Cadherin domain;
575-661 4.59e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 65.40  E-value: 4.59e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 730229393  575 VPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATEPGLFSMWAHNGEVRTARLLSERDAAKHRLVVLVKDNGEPPRSAT 654
Cdd:pfam00028   5 VPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLSST 84


                  ....*..
gi 730229393  655 ATLHVLL 661
Cdd:pfam00028  85 ATVTITV 91
Cadherin pfam00028
Cadherin domain;
142-233 1.94e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 63.86  E-value: 1.94e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 730229393  142 IPESTQPGTvFPLKI-AQDFDIGSNTVQNYTIS---PNSHFHVATHNRgdgrkypELVLDKALDREERPELSLTLTALDG 217
Cdd:pfam00028   5 VPENAPVGT-EVLTVtATDPDLGPNGRIFYSILgggPGGNFRIDPDTG-------DISTTKPLDRESIGEYELTVEATDS 76

                          90
                  ....*....|....*.
gi 730229393  218 GAPPRSGTTTIRIVVL 233
Cdd:pfam00028  77 GGPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
356-440 4.07e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 62.70  E-value: 4.07e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 730229393  356 PENAPE-TVVAVFSVSDPDSGDNGRMICSIQNDLPFllkptlKNFY------TLVTQRTLDRESQAEYNITITVTDMGTP 428
Cdd:pfam00028   6 PENAPVgTEVLTVTATDPDLGPNGRIFYSILGGGPG------GNFRidpdtgDISTTKPLDRESIGEYELTVEATDSGGP 79

                          90
                  ....*....|..
gi 730229393  429 RLKTEHNITVLV 440
Cdd:pfam00028  80 PLSSTATVTITV 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 32-129 3.53e-05

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 43.07  E-value: 3.53e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 730229393  32 RYSIPEETESGYSVANL-AKDLGLGVGelatrgARMHYK----GNKELLQLDIKTGNLLLYEKLDREvmcgatEPCILHF 106
Cdd:cd11304    3 EVSVPENAPPGTVVLTVsATDPDSGEN------GEVTYSivsgNEDGLFSIDPSTGEITTAKPLDRE------EQSSYTL 70

                         90       100
                 ....*....|....*....|....*...
gi 730229393 107 QLLLENPVQFFQTD-----LQLTDINDH 129
Cdd:cd11304   71 TVTATDGGGPPLSStatvtITVLDVNDN 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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