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Conserved domains on  [gi|9633780|ref|NP_051858|]
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m144R [Myxoma virus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PHA02639 super family cl31493
EEV host range protein; Provisional
 64-282 5.46e-52

EEV host range protein; Provisional


The actual alignment was detected with superfamily member PHA02639:

Pssm-ID: 165022 [Multi-domain]  Cd Length: 295  Bit Score: 172.54  E-value: 5.46e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9633780    64 TCGKD-NTWRISNEY-VCVRRECPDPPTIENGRVHTPKIMYHRHDAVRYVCNEnHKSIPYSLVGEDVVRCINETTWYPSP 141
Cdd:PHA02639  63 TCIKDkNNAIWSNKApFCMLKECNDPPSIINGKIYNKREMYKVGDEIYYVCNE-HKGVQYSLVGNEKITCIQDKSWKPDP 141

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9633780   142 PTCKMIVCRFPALQNGYVHGVPFIKRFCYKNRVRFTCNPDFTLVGASYATCTLNATWSPDVPKCVRRAHDSNtrnifafV 221
Cdd:PHA02639 142 PICKMINCRFPALQNGYINGIPSNKKFYYKTRVGFSCKSGFDLVGEKYSTCNINATWFPSIPTCVRNKPIDD-------I 214

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 9633780   222 EYDDFEDLDDEDAVNEKLTDTSTRPDDATSDRPS------HVFVALVILGTILFIFTLGVILLFCSC 282
Cdd:PHA02639 215 IYLKPVDDNFDDLDNEDKINTILHNNDANSTRINqekengNIFTVIILLSIISFMFILGVLSLLCSC 281
 
Name Accession Description Interval E-value
PHA02639 PHA02639
EEV host range protein; Provisional
 64-282 5.46e-52

EEV host range protein; Provisional


Pssm-ID: 165022 [Multi-domain]  Cd Length: 295  Bit Score: 172.54  E-value: 5.46e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9633780    64 TCGKD-NTWRISNEY-VCVRRECPDPPTIENGRVHTPKIMYHRHDAVRYVCNEnHKSIPYSLVGEDVVRCINETTWYPSP 141
Cdd:PHA02639  63 TCIKDkNNAIWSNKApFCMLKECNDPPSIINGKIYNKREMYKVGDEIYYVCNE-HKGVQYSLVGNEKITCIQDKSWKPDP 141

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9633780   142 PTCKMIVCRFPALQNGYVHGVPFIKRFCYKNRVRFTCNPDFTLVGASYATCTLNATWSPDVPKCVRRAHDSNtrnifafV 221
Cdd:PHA02639 142 PICKMINCRFPALQNGYINGIPSNKKFYYKTRVGFSCKSGFDLVGEKYSTCNINATWFPSIPTCVRNKPIDD-------I 214

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 9633780   222 EYDDFEDLDDEDAVNEKLTDTSTRPDDATSDRPS------HVFVALVILGTILFIFTLGVILLFCSC 282
Cdd:PHA02639 215 IYLKPVDDNFDDLDNEDKINTILHNNDANSTRINqekengNIFTVIILLSIISFMFILGVLSLLCSC 281
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 84-144 3.67e-11

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 57.54  E-value: 3.67e-11
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 9633780      84 CPDPPTIENGRVHTPKIMYHRHDAVRYVCNENhksipYSLVGEDVVRCINETTWYPSPPTC 144
Cdd:smart00032   1 CPPPPDIENGTVTSSSGTYSYGDTVTYSCDPG-----YTLIGSSTITCLENGTWSPPPPTC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
84-144 1.77e-10

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 55.58  E-value: 1.77e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 9633780     84 CPDPPTIENGRVHTPKIMYHRHDAVRYVCNENhksipYSLVGEDVVRCINETTWYPSPPTC 144
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNEYNYGASVSYECDPG-----YRLVGSPTITCQEDGTWSPPFPEC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 84-145 3.32e-10

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 54.78  E-value: 3.32e-10
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 9633780   84 CPDPPTIENGRVHTPKIMYHRHDAVRYVCNENhksipYSLVGEDVVRCINETTWYPSPPTCK 145
Cdd:cd00033   1 CPPPPVPENGTVTGSKGSYSYGSTVTYSCNEG-----YTLVGSSTITCTENGGWSPPPPTCE 57
 
Name Accession Description Interval E-value
PHA02639 PHA02639
EEV host range protein; Provisional
 64-282 5.46e-52

EEV host range protein; Provisional


Pssm-ID: 165022 [Multi-domain]  Cd Length: 295  Bit Score: 172.54  E-value: 5.46e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9633780    64 TCGKD-NTWRISNEY-VCVRRECPDPPTIENGRVHTPKIMYHRHDAVRYVCNEnHKSIPYSLVGEDVVRCINETTWYPSP 141
Cdd:PHA02639  63 TCIKDkNNAIWSNKApFCMLKECNDPPSIINGKIYNKREMYKVGDEIYYVCNE-HKGVQYSLVGNEKITCIQDKSWKPDP 141

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9633780   142 PTCKMIVCRFPALQNGYVHGVPFIKRFCYKNRVRFTCNPDFTLVGASYATCTLNATWSPDVPKCVRRAHDSNtrnifafV 221
Cdd:PHA02639 142 PICKMINCRFPALQNGYINGIPSNKKFYYKTRVGFSCKSGFDLVGEKYSTCNINATWFPSIPTCVRNKPIDD-------I 214

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 9633780   222 EYDDFEDLDDEDAVNEKLTDTSTRPDDATSDRPS------HVFVALVILGTILFIFTLGVILLFCSC 282
Cdd:PHA02639 215 IYLKPVDDNFDDLDNEDKINTILHNNDANSTRINqekengNIFTVIILLSIISFMFILGVLSLLCSC 281
PHA02817 PHA02817
EEV Host range protein; Provisional
 79-285 7.87e-48

EEV Host range protein; Provisional


Pssm-ID: 165167 [Multi-domain]  Cd Length: 225  Bit Score: 159.72  E-value: 7.87e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9633780    79 CVRRECPDPPTIENGRVHTPKIMYHRHDAVRYVCNENHKSIPYSLVGEDVVRCINETTWYPSPPTCKMIVCRFPALQNGY 158
Cdd:PHA02817  19 CDLNKCCYPPSIKNGYIYNKKTEYNIGSNVTFFCGNNTRGVRYTLVGEKNIICEKDGKWNKEFPVCKIIRCRFPALQNGF 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9633780   159 VHGVPFIKRFCYKNRVRFTCNPDFTLVGASYATCTLNATWSPDVPKCVRrahDSNTRNIFAFveyddfEDLDDEDAVNEK 238
Cdd:PHA02817  99 VNGIPDSKKFYYESEVSFSCKPGFVLIGTKYSVCGINSSWIPKVPICSR---DNITYNKIYI------NKVNIDDNFFNQ 169

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 9633780   239 LTDTSTRPDDATSDRPSHVFVALVILGTILFIFTLGVILLFCSCTSS 285
Cdd:PHA02817 170 INNSNTYYFDKILQINNVNRYTLIFFVVVSIKILFGFVFIFFSCNKK 216
PHA02831 PHA02831
EEV host range protein; Provisional
 23-298 4.58e-41

EEV host range protein; Provisional


Pssm-ID: 165176 [Multi-domain]  Cd Length: 268  Bit Score: 143.21  E-value: 4.58e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9633780    23 KNDFK-SNVQAVNKKqTYKQDEVTELQCVPGYQKksnvtISATCgKDNTWRISNeyVCV-RRECPDPPTIENGRVHTPKI 100
Cdd:PHA02831  24 KNDAKySNVDSYENK-VYEENENLEYKCNNNFDK-----VFVTC-NNGSWSTKN--MCIgKRNCKDPVTILNGYIKNKKD 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9633780   101 MYHRHDAVRYVCNENhKSIPYSLVGEDVVRCINETtWYPSPPTCKMIVCRFPALQNGYVHGvpFIKRFCYKNRVRFTCNP 180
Cdd:PHA02831  95 QYSFGDSVTYACKVN-KLEKYSIVGNETVKCINKQ-WVPKYPVCKLIRCKYPALQNGFLNV--FEKKFYYGDIVNFKCKK 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9633780   181 DFTLVGASYATCTLNATWSPDVPKCVRRAHDSNTRNIFAFveyddfedlddedavneKLTDTSTRPDDATSDRPSHVFVA 260
Cdd:PHA02831 171 GFILLGSSVSTCDINSIWYPGIPKCVKDKVHNEIQPNYLF-----------------DDLDEDFNNSTTNYNMQQNIITI 233

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 9633780   261 LVILGTILFIFTLGVILLFCSCTSSNILHPnklSYTKL 298
Cdd:PHA02831 234 IILLSIICFIFVLGLIALFLSCNKSTLKPS---IYNKF 268
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 26-207 2.27e-23

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 96.26  E-value: 2.27e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9633780    26 FKSNVQAvNKKQTYKQDEVTELQCVPGYQKKSNVTISATCgKDNTWRISNEyvCVRRECPDPPTIENGRVHT-------- 97
Cdd:PHA02927  32 FKNSVET-DANANYNIGDTIEYLCLPGYRKQKMGPIYAKC-TGTGWTLFNQ--CIKRRCPSPRDIDNGQLDIggvdfgss 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9633780    98 --------------------------------------------PKIMYHRHDA----------VRYVCNENhksipYSL 123
Cdd:PHA02927 108 ityscnsgyqligesksycelgstgsmvwnpeapicesvkcqspPSISNGRHNGyedfytdgsvVTYSCNSG-----YSL 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9633780   124 VGEDVVRCiNETTWyPSPPTCKMIVCRFPALQNGYVHGvPFIKRFCYKNRVRFTCNPDFTLVGASYATCTLNATWSPDVP 203
Cdd:PHA02927 183 IGNSGVLC-SGGEW-SDPPTCQIVKCPHPTISNGYLSS-GFKRSYSYNDNVDFKCKYGYKLSGSSSSTCSPGNTWQPELP 259


                 ....
gi 9633780   204 KCVR 207
Cdd:PHA02927 260 KCVR 263
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 84-144 3.67e-11

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 57.54  E-value: 3.67e-11
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 9633780      84 CPDPPTIENGRVHTPKIMYHRHDAVRYVCNENhksipYSLVGEDVVRCINETTWYPSPPTC 144
Cdd:smart00032   1 CPPPPDIENGTVTSSSGTYSYGDTVTYSCDPG-----YTLIGSSTITCLENGTWSPPPPTC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
84-144 1.77e-10

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 55.58  E-value: 1.77e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 9633780     84 CPDPPTIENGRVHTPKIMYHRHDAVRYVCNENhksipYSLVGEDVVRCINETTWYPSPPTC 144
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNEYNYGASVSYECDPG-----YRLVGSPTITCQEDGTWSPPFPEC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 84-145 3.32e-10

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 54.78  E-value: 3.32e-10
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 9633780   84 CPDPPTIENGRVHTPKIMYHRHDAVRYVCNENhksipYSLVGEDVVRCINETTWYPSPPTCK 145
Cdd:cd00033   1 CPPPPVPENGTVTGSKGSYSYGSTVTYSCNEG-----YTLVGSSTITCTENGGWSPPPPTCE 57
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 149-206 1.13e-09

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 53.24  E-value: 1.13e-09
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 9633780  149 CRFP-ALQNGYVhgVPFIKRFCYKNRVRFTCNPDFTLVGASYATCTLNATWSPDVPKCV 206
Cdd:cd00033   1 CPPPpVPENGTV--TGSKGSYSYGSTVTYSCNEGYTLVGSSTITCTENGGWSPPPPTCE 57
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 149-205 2.60e-09

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 52.53  E-value: 2.60e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 9633780     149 CRFP-ALQNGYVHGVPfiKRFCYKNRVRFTCNPDFTLVGASYATCTLNATWSPDVPKC 205
Cdd:smart00032   1 CPPPpDIENGTVTSSS--GTYSYGDTVTYSCDPGYTLIGSSTITCLENGTWSPPPPTC 56
PHA02954 PHA02954
EEV membrane glycoprotein; Provisional
 35-286 6.32e-08

EEV membrane glycoprotein; Provisional


Pssm-ID: 165263 [Multi-domain]  Cd Length: 317  Bit Score: 53.17  E-value: 6.32e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9633780    35 KKQTYKQDEVTELQCVPGYQKKSNVTISAT-------CGKDNTWRISNEYV-CVRRECpDPPTIENGRVHTPKIMYHRHD 106
Cdd:PHA02954  73 KKMCTVSDYVSELYDKPLYEVNSTITLICKdetkyfrCEEKNGNTSWNDTVtCPNAEC-QPLQLEHGSCQPVKEKYSFGE 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9633780   107 AVRYVCNenhksIPYSLVGEDVVRCINETtwYPSPPTCKMiVCRFPALQNGYVHGvpfiKRFCYKNRVRFTCNPDFTLVG 186
Cdd:PHA02954 152 HITINCD-----VGYEVIGASYISCTANS--WNVIPSCQQ-KCDIPSLSNGLISG----STFSIGGVIHLSCKSGFTLTG 219

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9633780   187 ASYATCtLNATWSPDVPKCVRrahdsntrnifafveyddfedlddedaVNEKLTDTSTRPDDATS--------------- 251
Cdd:PHA02954 220 SPSSTC-IDGKWNPVLPICVR---------------------------SNEEFDPVDDGPDDETDlsklskdvvqyeqei 271

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 9633780   252 ---DRPSHVF-VALVILGTIlfiFTLGVILLFCSCTSSN 286
Cdd:PHA02954 272 eslEATYHIIiVALTIMGVI---FLISVIVLVCSCNKNN 307
Sushi pfam00084
Sushi repeat (SCR repeat);
152-205 1.37e-07

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 47.49  E-value: 1.37e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 9633780    152 PALQNGYVHGVPFikRFCYKNRVRFTCNPDFTLVGASYATCTLNATWSPDVPKC 205
Cdd:pfam00084   5 PDIPNGKVSATKN--EYNYGASVSYECDPGYRLVGSPTITCQEDGTWSPPFPEC 56
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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