zinc finger HIT domain-containing protein 2 [Mus musculus]
Protein Classification
zinc finger HIT domain-containing protein( domain architecture ID 19225473)
zinc finger HIT domain-containing protein may be involved in Box C/D snoRNP Biogenesis
List of domain hits
| Name | Accession | Description | Interval | E-value | ||
| zf-HIT_ZNHIT2-3 | cd23024 | zinc finger HIT (zf-HIT) found in zinc finger HIT domain-containing protein 2 (ZNHIT2), 3 ... |
6-43 | 5.39e-14 | ||
zinc finger HIT (zf-HIT) found in zinc finger HIT domain-containing protein 2 (ZNHIT2), 3 (ZNHIT3) and similar proteins; ZNHIT2 and ZNHIT3 are members of the zf-HIT domain-containing protein family that play crucial roles in various biological processes. ZNHIT2 acts as a bridging factor between the R2TP/PFDL complex and U5 snRNP, while ZNHIT3 interacts specifically with the ligand binding domain of the thyroid receptor and is involved in small nucleolar ribonucleoprotein particle assembly, transcriptional regulation, and snoRNP assembly. ZNHIT3 is also associated with HNF-4alpha and may play a role in MODY, while its dysfunction is linked to PEHO syndrome. Both proteins contain the zf-HIT domain and interact with other proteins through their HIT-type zinc finger in the presence of ATP, ADP, or other factors. : Pssm-ID: 467796 [Multi-domain] Cd Length: 37 Bit Score: 65.36 E-value: 5.39e-14
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| Name | Accession | Description | Interval | E-value | ||
| zf-HIT_ZNHIT2-3 | cd23024 | zinc finger HIT (zf-HIT) found in zinc finger HIT domain-containing protein 2 (ZNHIT2), 3 ... |
6-43 | 5.39e-14 | ||
zinc finger HIT (zf-HIT) found in zinc finger HIT domain-containing protein 2 (ZNHIT2), 3 (ZNHIT3) and similar proteins; ZNHIT2 and ZNHIT3 are members of the zf-HIT domain-containing protein family that play crucial roles in various biological processes. ZNHIT2 acts as a bridging factor between the R2TP/PFDL complex and U5 snRNP, while ZNHIT3 interacts specifically with the ligand binding domain of the thyroid receptor and is involved in small nucleolar ribonucleoprotein particle assembly, transcriptional regulation, and snoRNP assembly. ZNHIT3 is also associated with HNF-4alpha and may play a role in MODY, while its dysfunction is linked to PEHO syndrome. Both proteins contain the zf-HIT domain and interact with other proteins through their HIT-type zinc finger in the presence of ATP, ADP, or other factors. Pssm-ID: 467796 [Multi-domain] Cd Length: 37 Bit Score: 65.36 E-value: 5.39e-14
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| zf-HIT | pfam04438 | HIT zinc finger; This presumed zinc finger contains up to 6 cysteine residues that could ... |
3-36 | 9.02e-11 | ||
HIT zinc finger; This presumed zinc finger contains up to 6 cysteine residues that could coordinate zinc. The domain is named after the HIT protein. This domain is also found in the Thyroid receptor interacting protein 3 (TRIP-3) that specifically interact with the ligand binding domain of the thyroid receptor. Pssm-ID: 461310 Cd Length: 30 Bit Score: 56.10 E-value: 9.02e-11
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| Name | Accession | Description | Interval | E-value | ||
| zf-HIT_ZNHIT2-3 | cd23024 | zinc finger HIT (zf-HIT) found in zinc finger HIT domain-containing protein 2 (ZNHIT2), 3 ... |
6-43 | 5.39e-14 | ||
zinc finger HIT (zf-HIT) found in zinc finger HIT domain-containing protein 2 (ZNHIT2), 3 (ZNHIT3) and similar proteins; ZNHIT2 and ZNHIT3 are members of the zf-HIT domain-containing protein family that play crucial roles in various biological processes. ZNHIT2 acts as a bridging factor between the R2TP/PFDL complex and U5 snRNP, while ZNHIT3 interacts specifically with the ligand binding domain of the thyroid receptor and is involved in small nucleolar ribonucleoprotein particle assembly, transcriptional regulation, and snoRNP assembly. ZNHIT3 is also associated with HNF-4alpha and may play a role in MODY, while its dysfunction is linked to PEHO syndrome. Both proteins contain the zf-HIT domain and interact with other proteins through their HIT-type zinc finger in the presence of ATP, ADP, or other factors. Pssm-ID: 467796 [Multi-domain] Cd Length: 37 Bit Score: 65.36 E-value: 5.39e-14
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| zf-HIT | cd23020 | zinc finger HIT (zf-HIT) domain; The zinc finger HIT (zf-HIT) is a novel zinc-binding domain ... |
6-39 | 1.68e-11 | ||
zinc finger HIT (zf-HIT) domain; The zinc finger HIT (zf-HIT) is a novel zinc-binding domain with about 50 amino acids. It is characterized by a fold in "treble-clef" through interleaved CCCC and CCHC zinc finger motifs that both bind a zinc ion. zf-HIT domain may function as a protein-protein interaction domain. It is mainly found in nuclear proteins involved in gene regulation and chromatin remodeling. The zf-HIT family includes six proteins containing zf-HIT domain present in human and three in yeast proteome, all belonging to multimodular RNA/protein complexes. Pssm-ID: 467792 Cd Length: 31 Bit Score: 58.28 E-value: 1.68e-11
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| zf-HIT | pfam04438 | HIT zinc finger; This presumed zinc finger contains up to 6 cysteine residues that could ... |
3-36 | 9.02e-11 | ||
HIT zinc finger; This presumed zinc finger contains up to 6 cysteine residues that could coordinate zinc. The domain is named after the HIT protein. This domain is also found in the Thyroid receptor interacting protein 3 (TRIP-3) that specifically interact with the ligand binding domain of the thyroid receptor. Pssm-ID: 461310 Cd Length: 30 Bit Score: 56.10 E-value: 9.02e-11
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| zf-HIT_BCD1 | cd23023 | zinc finger HIT (zf-HIT) found in Box C/D snoRNA protein 1 (BCD1) and similar proteins; The ... |
5-38 | 4.91e-08 | ||
zinc finger HIT (zf-HIT) found in Box C/D snoRNA protein 1 (BCD1) and similar proteins; The zf-HIT domain-containing family includes BCD1 and its yeast counterpart Bcd1p, both of which have been characterized as assembly factors for box C/D snoRNPs. BCD1, also known as serologically defined breast cancer antigen NY-BR-75 or zinc finger HIT domain-containing protein 6 (ZNHIT6), is required for the accumulation, processing, transport, and biogenesis of box C/D snoRNAs, specifically U3 and U8, in the nucleoplasm. Bcd1p is essential for cellular viability in Saccharomyces cerevisiae and contributes to the specific stability of box C/D snoRNAs. Members of this family contain a zf-HIT domain, characterized by a fold in "treble-clef" through interleaved CCCC and CCHC ZnF motifs that both bind a zinc atom. The zf-HIT domain of Bcd1p is necessary but not sufficient for yeast growth, and although it lacks direct RNA-binding capacity, it helps Bcd1p maintain steady-state levels of box C/D snoRNAs. Additionally, the zf-HIT domain of Bcd1p is functionally interchangeable with that of Hit1p, another box C/D snoRNP assembly factor belonging to the zf-HIT family. Pssm-ID: 467795 Cd Length: 40 Bit Score: 48.77 E-value: 4.91e-08
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| zf-HIT_ZNHIT1_like | cd21437 | HIT zinc finger found in zinc finger HIT domain-containing protein 1 (ZNHIT1) and similar ... |
7-38 | 3.31e-07 | ||
HIT zinc finger found in zinc finger HIT domain-containing protein 1 (ZNHIT1) and similar proteins; The family includes ZNHIT1 and its yeast counterpart, the vacuolar protein sorting-associated protein 71 (Vps71p). ZNHIT1, also known as cyclin-G1-binding protein 1 (CGBP1), zinc finger protein subfamily 4A member 1 (ZNFN4A1), or p18 Hamlet, may have a role in inducing apoptosis through p53 signaling. It binds to Rev-erb beta and releases its inhibitory effect on the transcription of apolipoprotein C3 (APOC3) without affecting its DNA-binding activity. The yeast counterpart Vps71p, also referred to as SWR complex protein 6 (Swc6p), plays a role in the exchange of histone H2A for the H2A variant HZT1, a euchromatin-specific factor, leading to chromatin remodeling and transcriptional changes of targeted genes. It is indirectly involved in vacuolar protein sorting. Members of this family contain a zf-HIT domain characterized by a "treble-clef" fold through interleaved CCCC and CCHC zinc finger motifs, both of which bind a zinc ion. Pssm-ID: 467791 Cd Length: 43 Bit Score: 46.46 E-value: 3.31e-07
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| zf-HIT_IN80B | cd23021 | zinc finger HIT (zf-HIT) found in INO80 complex subunit B (INO80B) and similar proteins; ... |
17-37 | 1.20e-04 | ||
zinc finger HIT (zf-HIT) found in INO80 complex subunit B (INO80B) and similar proteins; INO80B, also called high mobility group AT-hook 1-like 4 (HMGA1L4), or IES2 homolog, or PAP-1-associated protein 1 (PAPA-1), or zinc finger HIT domain-containing protein 4 (ZNHIT4), is a nucleolar protein that induces growth and cell cycle arrests at the G1 phase of the cell cycle. It is a core component of the chromatin remodeling INO80 complex, which is involved in transcriptional regulation, DNA replication and probably DNA repair. INO80B harbors a zf-HIT domain which is characterized by a fold in "treble-clef" through interleaved CCCC and CCHC ZnF motifs that both bind a zinc atom. The yeast counterpart of INO80B is Ies2p (Ino eighty subunit 2), which doesn't have zf-HIT domain. Pssm-ID: 467793 Cd Length: 33 Bit Score: 38.80 E-value: 1.20e-04
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| Bbox1_TRIM8-like | cd19802 | B-box-type 1 zinc finger found in tripartite motif-containing proteins, TRIM8, TRIM16, TRIM25, ... |
6-38 | 4.84e-04 | ||
B-box-type 1 zinc finger found in tripartite motif-containing proteins, TRIM8, TRIM16, TRIM25, TRIM29, TRIM44, TRIM47 and similar proteins; This family includes a group of tripartite motif-containing proteins, including TRIM8, TRIM16, TRIM25, TRIM29, TRIM44 and TRIM47. TRIM8, also known as glioblastoma-expressed RING finger protein (GERP) or RING finger protein 27 (RNF27), is a probable E3 ubiquitin-protein ligase that may promote proteasomal degradation of suppressor of cytokine signaling 1 (SOCS1) and further regulate interferon-gamma signaling. It functions as a new p53 modulator that stabilizes p53, impairing its association with MDM2 and inducing the reduction of cell proliferation. TRIM16, also termed estrogen-responsive B box protein (EBBP), may play a role in the regulation of keratinocyte differentiation. It may also act as a tumor suppressor by affecting cell proliferation and migration or tumorigenicity in carcinogenesis. TRIM25, also termed estrogen-responsive finger protein (EFP), or ubiquitin/ISG15-conjugating enzyme TRIM25, or zinc finger protein 147 (ZNF147), or E3 ubiquitin/ISG15 ligase TRIM25, is induced by estrogen and is particularly abundant in placenta and uterus. It has been implicated in cell proliferation, protein modification, and the retinoic acid inducible gene I (RIG-I)-mediated antiviral signaling pathway. It functions as an E3-ubiquitin ligase able to transfer ubiquitin and ISG15 to target proteins. TRIM29, also termed ataxia telangiectasia group D-associated protein (ATDC), plays a crucial role in the regulation of macrophage activation in response to viral or bacterial infections within the respiratory tract. TRIM44, also termed protein DIPB, functions as a critical regulator in tumor metastasis and progression. TRIM47, also known as gene overexpressed in astrocytoma protein (GOA) or RING finger protein 100 (RNF100), plays an important role in the process of dedifferentiation that is associated with astrocytoma tumorigenesis. The TRIM (tripartite motif) family of proteins are defined by their N-terminal RBCC (RING, Bbox, and coiled coil) domains, including three consecutive zinc-binding domains, a RING finger, Bbox1 and Bbox2, and a coiled coil domain. The type 1 B-box (Bbox1) zinc finger is characterized by a C6H2 zinc-binding consensus motif. Pssm-ID: 380860 Cd Length: 46 Bit Score: 37.79 E-value: 4.84e-04
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