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Conserved domains on  [gi|1938531436|ref|NP_036985|]
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5-hydroxytryptamine receptor 4 [Rattus norvegicus]

Protein Classification

G protein-coupled receptor family protein; olfactory receptor subfamily 2A protein( domain architecture ID 11606725)

G protein-coupled receptor family protein is a seven-transmembrane G protein-coupled receptor (7TM-GPCR) family protein which typically transmits an extracellular signal into the cell by the conformational rearrangement of the 7TM helices and by the subsequent binding and activation of an intracellular heterotrimeric G protein; GPCR ligands include light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters| olfactory receptor (OR) subfamily 2A protein, such as human olfactory receptor 2A2 and related proteins in other mammals and sauropsids; ORs play a central role in olfaction, the sense of smell, and belong to the class A rhodopsin-like family of seven-transmembrane G protein-coupled receptors (7TM GPCRs)

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7tmA_5-HT4 cd15056
serotonin receptor subtype 4, member of the class A family of seven-transmembrane G ...
20-323 4.08e-176

serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT4 subtype is a member of the serotonin receptor family that belongs to the class A G protein-coupled receptors, and binds the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT4 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. 5-HT4 receptor-specific agonists have been shown to enhance learning and memory in animal studies. Moreover, hippocampal 5-HT4 receptor expression has been reported to be inversely correlated with memory performance in humans. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


:

Pssm-ID: 320184 [Multi-domain]  Cd Length: 294  Bit Score: 492.00  E-value: 4.08e-176
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKiKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSL 99
Cdd:cd15056     1 VVLSTFLSLVILLTILGNLLVIVAVCTDRQLRK-KTNYFVVSLAVADLLVAVLVMPFGAIELVNNRWIYGETFCLVRTSL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 100 DVLLTTASIFHLCCISLDRYYAICCQPLVYrnKMTPLRIALMLGGCWVIPMFISFLPIMQGWNNIGIVDVIekrKFNHNS 179
Cdd:cd15056    80 DVLLTTASIMHLCCIALDRYYAICCQPLVY--KMTPLRVAVMLGGCWVIPTFISFLPIMQGWNHIGIEDLI---AFNCAS 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 180 NSTFCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAQQIQMLQRAGatseSRPQTADQHSTHRMRTETKAAK 259
Cdd:cd15056   155 GSTSCVFMVNKPFAIICSTVAFYIPALLMVLAYYRIYVAAREQAHQIRSLQRAG----SSNHEADQHRNSRMRTETKAAK 230
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1938531436 260 TLCVIMGCFCFCWAPFFVTNIVDPFIDYTVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15056   231 TLGIIMGCFCVCWAPFFVTNIVDPFIGYRVPYLLWTAFLWLGYINSGLNPFLYAFFNKSFRRAF 294
 
Name Accession Description Interval E-value
7tmA_5-HT4 cd15056
serotonin receptor subtype 4, member of the class A family of seven-transmembrane G ...
20-323 4.08e-176

serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT4 subtype is a member of the serotonin receptor family that belongs to the class A G protein-coupled receptors, and binds the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT4 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. 5-HT4 receptor-specific agonists have been shown to enhance learning and memory in animal studies. Moreover, hippocampal 5-HT4 receptor expression has been reported to be inversely correlated with memory performance in humans. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320184 [Multi-domain]  Cd Length: 294  Bit Score: 492.00  E-value: 4.08e-176
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKiKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSL 99
Cdd:cd15056     1 VVLSTFLSLVILLTILGNLLVIVAVCTDRQLRK-KTNYFVVSLAVADLLVAVLVMPFGAIELVNNRWIYGETFCLVRTSL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 100 DVLLTTASIFHLCCISLDRYYAICCQPLVYrnKMTPLRIALMLGGCWVIPMFISFLPIMQGWNNIGIVDVIekrKFNHNS 179
Cdd:cd15056    80 DVLLTTASIMHLCCIALDRYYAICCQPLVY--KMTPLRVAVMLGGCWVIPTFISFLPIMQGWNHIGIEDLI---AFNCAS 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 180 NSTFCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAQQIQMLQRAGatseSRPQTADQHSTHRMRTETKAAK 259
Cdd:cd15056   155 GSTSCVFMVNKPFAIICSTVAFYIPALLMVLAYYRIYVAAREQAHQIRSLQRAG----SSNHEADQHRNSRMRTETKAAK 230
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1938531436 260 TLCVIMGCFCFCWAPFFVTNIVDPFIDYTVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15056   231 TLGIIMGCFCVCWAPFFVTNIVDPFIGYRVPYLLWTAFLWLGYINSGLNPFLYAFFNKSFRRAF 294
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
36-312 5.77e-63

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 202.53  E-value: 5.77e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  36 GNLLVMVAVCRDRQLRKIkTNYFIVSLAFADLLVSVLVMPFGAIELVQDI-WFYGEMFCLVRTSLDVLLTTASIFHLCCI 114
Cdd:pfam00001   1 GNLLVILVILRNKKLRTP-TNIFLLNLAVADLLFSLLTLPFWLVYYLNHGdWPFGSALCKIVGALFVVNGYASILLLTAI 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 115 SLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMQGWNNigivdviekrkFNHNSNSTFCVFMVNKP--- 191
Cdd:pfam00001  80 SIDRYLAI-VHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFGWTL-----------TVPEGNVTVCFIDFPEDlsk 147
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 192 ---YAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAQQiqmlqragatsesrpqtadQHSTHRMRTETKAAKTLCVIMGCF 268
Cdd:pfam00001 148 pvsYTLLISVLGFLLPLLVILVCYTLIIRTLRKSASK-------------------QKSSERTQRRRKALKTLAVVVVVF 208
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1938531436 269 CFCWAPFFVTNIVDPFIDYTVPE----KVWTAFLWLGYINSGLNPFLY 312
Cdd:pfam00001 209 ILCWLPYHIVNLLDSLALDCELSrlldKALSVTLWLAYVNSCLNPIIY 256
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
19-281 3.90e-11

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 63.64  E-value: 3.90e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  19 KVVLLTFFAMVILMAILGNLLVMVAVCRdrqlRKIKT--NYFIVSLAFADLLVsVLVMPFGAIELVQDIWFYGEMFCLVR 96
Cdd:PHA03087   40 STILIVVYSTIFFFGLVGNIIVIYVLTK----TKIKTpmDIYLLNLAVSDLLF-VMTLPFQIYYYILFQWSFGEFACKIV 114
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  97 TSLDVLLTTASIFHLCCISLDRYYAICcQPLVYrNKMTPLRIALMLGGC-WVIPMFISFlPIMqgwnnigIVDVIEK--- 172
Cdd:PHA03087  115 SGLYYIGFYNSMNFITVMSVDRYIAIV-HPVKS-NKINTVKYGYIVSLViWIISIIETT-PIL-------FVYTTKKdhe 184
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 173 ---RKFNHNSNSTFCVFMVNkpyaITCSVVAFYIPFLLMVLAYYRIYVTAKehaqQIQMLQRAgatsesrpqtadqhsth 249
Cdd:PHA03087  185 tliCCMFYNNKTMNWKLFIN----FEINIIGMLIPLTILLYCYSKILITLK----GINKSKKN----------------- 239
                         250       260       270
                  ....*....|....*....|....*....|..
gi 1938531436 250 rmrteTKAAKTLCVIMGCFCFCWAPFFVTNIV 281
Cdd:PHA03087  240 -----KKAIKLVLIIVILFVIFWLPFNVSVFV 266
 
Name Accession Description Interval E-value
7tmA_5-HT4 cd15056
serotonin receptor subtype 4, member of the class A family of seven-transmembrane G ...
20-323 4.08e-176

serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT4 subtype is a member of the serotonin receptor family that belongs to the class A G protein-coupled receptors, and binds the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT4 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. 5-HT4 receptor-specific agonists have been shown to enhance learning and memory in animal studies. Moreover, hippocampal 5-HT4 receptor expression has been reported to be inversely correlated with memory performance in humans. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320184 [Multi-domain]  Cd Length: 294  Bit Score: 492.00  E-value: 4.08e-176
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKiKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSL 99
Cdd:cd15056     1 VVLSTFLSLVILLTILGNLLVIVAVCTDRQLRK-KTNYFVVSLAVADLLVAVLVMPFGAIELVNNRWIYGETFCLVRTSL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 100 DVLLTTASIFHLCCISLDRYYAICCQPLVYrnKMTPLRIALMLGGCWVIPMFISFLPIMQGWNNIGIVDVIekrKFNHNS 179
Cdd:cd15056    80 DVLLTTASIMHLCCIALDRYYAICCQPLVY--KMTPLRVAVMLGGCWVIPTFISFLPIMQGWNHIGIEDLI---AFNCAS 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 180 NSTFCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAQQIQMLQRAGatseSRPQTADQHSTHRMRTETKAAK 259
Cdd:cd15056   155 GSTSCVFMVNKPFAIICSTVAFYIPALLMVLAYYRIYVAAREQAHQIRSLQRAG----SSNHEADQHRNSRMRTETKAAK 230
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1938531436 260 TLCVIMGCFCFCWAPFFVTNIVDPFIDYTVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15056   231 TLGIIMGCFCVCWAPFFVTNIVDPFIGYRVPYLLWTAFLWLGYINSGLNPFLYAFFNKSFRRAF 294
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
21-323 6.06e-101

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 299.48  E-value: 6.06e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  21 VLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIkTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSLD 100
Cdd:cd14967     1 LLAVFLSLIILVTVFGNLLVILAVYRNRRLRTV-TNYFIVSLAVADLLVALLVMPFSAVYTLLGYWPFGPVLCRFWIALD 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 101 VLLTTASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMQGWNNIGIVDVIEKrkfnhnsn 180
Cdd:cd14967    80 VLCCTASILNLCAISLDRYLAI-TRPLRYRQLMTKKRALIMIAAVWVYSLLISLPPLVGWRDETQPSVVDCE-------- 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 181 stfCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAkehaqqiqmlqragatsesrpqtadqhsthrmRTETKAAKT 260
Cdd:cd14967   151 ---CEFTPNKIYVLVSSVISFFIPLLIMIVLYARIFRVA--------------------------------RRELKAAKT 195
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1938531436 261 LCVIMGCFCFCWAPFFVTNIVDPFIDY-TVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd14967   196 LAIIVGAFLLCWLPFFIIYLVSAFCPPdCVPPILYAVFFWLGYLNSALNPIIYALFNRDFRRAF 259
7tmA_D1-like_dopamine_R cd15057
D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G ...
25-323 5.60e-98

D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320185 [Multi-domain]  Cd Length: 299  Bit Score: 293.57  E-value: 5.60e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  25 FFAMVILMAILGNLLVMVAVCRDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEmFCLVRTSLDVLLT 104
Cdd:cd15057     6 ILYLLVLLTLLGNALVIAAVLRFRHLRSKVTNYFIVSLAVSDLLVAILVMPWAAVNEVAGYWPFGS-FCDVWVSFDIMCS 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 105 TASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMQGWNNIGivDVIEKRKFNHnsNSTFC 184
Cdd:cd15057    85 TASILNLCVISVDRYWAI-SSPFRYERRMTRRRAFIMIAVAWTLSALISFIPVQLGWHRAD--DTSEALALYA--DPCQC 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 185 VFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAQQIQMLQRAGATSESrpqtADQHSTHRMRTETKAAKTLCVI 264
Cdd:cd15057   160 DSSLNRTYAISSSLISFYIPVAIMIVTYTRIYRIARRQIRRIAALERAAQESTN----PDSSLRSSLRRETKALKTLSII 235
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1938531436 265 MGCFCFCWAPFFVTNIVDPFIDYT------VPEKVWTAFLWLGYINSGLNPFLYAFlNKSFRRAF 323
Cdd:cd15057   236 MGVFVCCWLPFFILNCVLPFCDLRtaqfpcVPDTTFIVFVWLGWANSSLNPIIYAF-NADFRKAF 299
7tmA_TAARs cd15055
trace amine-associated receptors, member of the class A family of seven-transmembrane G ...
20-323 9.65e-97

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320183 [Multi-domain]  Cd Length: 285  Bit Score: 289.84  E-value: 9.65e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKiKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSL 99
Cdd:cd15055     1 VLLYIVLSSISLLTVLGNLLVIISISHFKQLHT-PTNLLLLSLAVADFLVGLLVMPFSMIRSIETCWYFGDTFCKLHSSL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 100 DVLLTTASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMQGWNNIGIVDviekrkfnHNS 179
Cdd:cd15055    80 DYILTSASIFNLVLIAIDRYVAV-CDPLLYPTKITIRRVKICICLCWFVSALYSSVLLYDNLNQPGLIR--------YNS 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 180 NSTFCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAQQIQMLQRAGATSESRpqtadqhSTHRMRTETKAAK 259
Cdd:cd15055   151 CYGECVVVVNFIWGVVDLVLTFILPCTVMIVLYMRIFVVARSQARAIRSHTAQVSLEGSS-------KKVSKKSERKAAK 223
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1938531436 260 TLCVIMGCFCFCWAPFFVTNIVDPFIdyTVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15055   224 TLGIVVGVFLLCWLPYYIVSLVDPYI--STPSSVFDVLIWLGYFNSCLNPLIYALFYPWFRKAL 285
7tmA_Histamine_H2R cd15051
histamine subtype H2 receptor, member of the class A family of seven-transmembrane G ...
20-323 2.34e-92

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H2R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H2R subtype selectively interacts with the G(s)-type G protein that activates adenylate cyclase, leading to increased cAMP production and activation of Protein Kinase A. H2R is found in various tissues such as the brain, stomach, and heart. Its most prominent role is in histamine-induced gastric acid secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320179 [Multi-domain]  Cd Length: 287  Bit Score: 278.83  E-value: 2.34e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIkTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSL 99
Cdd:cd15051     1 IVLGVVLAVIILLTVIGNVLVCLAVAVNRRLRNL-TNYFIVSLAVTDLLLGLLVLPFSAIYELRGEWPLGPVFCNIYISL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 100 DVLLTTASIFHLCCISLDRYYAICcQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMQGWNNIGIvdviekrKFNHNS 179
Cdd:cd15051    80 DVMLCTASILNLFAISLDRYLAIT-APLRYPSRVTPRRVAIALAAIWVVSLAVSFLPIHLGWNTPDG-------RVQNGD 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 180 NSTFCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAQQIQMLQRA-GATSESRPQTADQHsthrmrtetKAA 258
Cdd:cd15051   152 TPNQCRFELNPPYVLLVAIGTFYLPLLIMCGVYLRIFRIAREQAKRINALTPAsTANSSKSAATAREH---------KAT 222
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1938531436 259 KTLCVIMGCFCFCWAPFFVTNIVDPFIDYTVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15051   223 VTLAAVLGAFIICWFPYFTYFTYRGLCGDNINETALSVVLWLGYANSALNPILYAFLNRDFRRAF 287
7tmA_Ap5-HTB1-like cd15065
serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...
21-323 7.86e-91

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.


Pssm-ID: 320193 [Multi-domain]  Cd Length: 300  Bit Score: 275.38  E-value: 7.86e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  21 VLLTFFAMVILMAILGNLLVMVAVCRDRQLRKiKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSLD 100
Cdd:cd15065     1 LIGIFLSLIIVLAIFGNVLVCLAIFTDRRLRK-KSNLFIVSLAVADLLVALLVMTFAVVNDLLGYWLFGETFCNIWISFD 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 101 VLLTTASIFHLCCISLDRYYAICcQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMQGWnniGIVDVIEKRKFNHNSN 180
Cdd:cd15065    80 VMCSTASILNLCAISLDRYIHIK-KPLKYERWMTTRRALVVIASVWILSALISFLPIHLGW---HRLSQDEIKGLNHASN 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 181 STF-CVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAQQIQmLQRAGATSESRPQTADQHSTHRMR--TETKA 257
Cdd:cd15065   156 PKPsCALDLNPTYAVVSSLISFYIPCLVMLLIYSRLYLYARKHVVNIK-SQKLPSESGSKFQVPSLSSKHNNQgvSDHKA 234
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1938531436 258 AKTLCVIMGCFCFCWAPFFVTNIVDPFIDYTVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15065   235 AVTLGIIMGVFLICWLPFFIINIIAAFCKTCIPPKCFKILTWLGYFNSCLNPIIYSIFNSEFRRAF 300
7tmA_TAAR1 cd15314
trace amine-associated receptor 1 and similar receptors, member of the class A family of ...
20-323 3.66e-89

trace amine-associated receptor 1 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 1 (TAAR1) is one of the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. TAAR1 is coupled to the Gs protein, which leads to activation of adenylate cyclase, and is thought to play functional role in the regulation of brain monoamines. TAAR1 is also shown to be activated by psychoactive compounds such as Ecstasy (MDMA), amphetamine and LSD. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320438 [Multi-domain]  Cd Length: 282  Bit Score: 270.65  E-value: 3.66e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRkIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSL 99
Cdd:cd15314     1 VLLYIFLGLISLVTVCGNLLVIISIAHFKQLH-TPTNYLILSLAVADLLVGGLVMPPSMVRSVETCWYFGDLFCKIHSSF 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 100 DVLLTTASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMQGWNNIGIVDviekrkfNHNS 179
Cdd:cd15314    80 DITLCTASILNLCFISIDRYYAV-CQPLLYRSKITVRVVLVMILISWSVSALVGFGIIFLELNIKGIYY-------NHVA 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 180 NSTFCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAQQIQMLQRAGATSESrpqtadqhsthrmRTETKAAK 259
Cdd:cd15314   152 CEGGCLVFFSKVSSVVGSVFSFYIPAVIMLCIYLKIFLVAQRQARSIQSARTKSGASSS-------------KMERKATK 218
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1938531436 260 TLCVIMGCFCFCWAPFFVTNIVDPFIDYTVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15314   219 TLAIVMGVFLLCWTPFFLCNIIDPFINYSIPPVLIEVLNWLGYSNSTLNPFIYAFFYSWFRKAF 282
7tmA_DmOct-betaAR-like cd15066
Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar ...
24-323 2.53e-85

Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar receptors in bilateria; member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila beta-adrenergic-like octopamine receptors and similar proteins. The biogenic amine octopamine is the invertebrate equivalent of vertebrate adrenergic neurotransmitters and exerts its effects through different G protein-coupled receptor types. Insect octopamine receptors are involved in the modulation of carbohydrate metabolism, muscular tension, cognition and memory. The activation of octopamine receptors mediating these actions leads to an increase in adenylate cyclase activity, thereby increasing cAMP levels. In Drosophila melanogaster, three subgroups have been classified on the basis of their structural homology and functional equivalents with vertebrate beta-adrenergic receptors: DmOctBeta1R, DmOctBeta2R, and DmOctBeta3R.


Pssm-ID: 320194 [Multi-domain]  Cd Length: 265  Bit Score: 260.00  E-value: 2.53e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  24 TFFAMVILMAILGNLLVMVAVCRDRQLRkIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSLDVLL 103
Cdd:cd15066     4 FAMTLIILAAIFGNLLVIISVMRHRKLR-VITNYFVVSLAMADMLVALCAMTFNASVEITGRWMFGYFMCDVWNSLDVYF 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 104 TTASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMQGWNNIGivdviEKRKFNhNSNSTF 183
Cdd:cd15066    83 STASILHLCCISVDRYYAI-VQPLEYPSKMTKRRVAIMLANVWISPALISFLPIFLGWYTTE-----EHLQYR-KTHPDQ 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 184 CVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEhaqqiqmlqragatsesrpqtadqhsthrmrtETKAAKTLCV 263
Cdd:cd15066   156 CEFVVNKIYALISSSVSFWIPCIVMIFTYYRIYLEAKR--------------------------------EHKAAKTLGI 203
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1938531436 264 IMGCFCFCWAPFF----VTNIVDPFIDYtvPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15066   204 IMGAFILCWLPFFlwyvTTTLCGDACPY--PPILVSILFWIGYFNSTLNPLIYAYFNRDFREAF 265
7tmA_TAAR2_3_4 cd15312
trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...
20-323 7.53e-84

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320437 [Multi-domain]  Cd Length: 289  Bit Score: 257.28  E-value: 7.53e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKiKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSL 99
Cdd:cd15312     1 VAMYLFMAGAILLTVFGNLMVIISISHFKQLHS-PTNFLILSLAITDFLLGFLVMPYSMVRSVESCWYFGDLFCKIHSSL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 100 DVLLTTASIFHLCCISLDRYYAICcQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMQGWNNIGIVDVIekrkfNHNS 179
Cdd:cd15312    80 DMMLSTTSIFHLCFIAVDRYYAVC-DPLHYRTKITTPVIKVFLVISWSVPCLFAFGVVFSEVNLEGIEDYV-----ALVS 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 180 NSTFCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAQQIQMLQRAgATSESRPQTADQhsthrmrTETKAAK 259
Cdd:cd15312   154 CTGSCVLIFNKLWGVIASLIAFFIPGTVMIGIYIKIFFVARKHAKVINNRPSV-TKGDSKNKLSKK-------KERKAAK 225
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1938531436 260 TLCVIMGCFCFCWAPFFVTNIVDPFIDYTVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15312   226 TLSIVMGVFLLCWLPFFVATLIDPFLNFSTPVDLFDALVWLGYFNSTCNPLIYGFFYPWFQKAF 289
7tmA_Dop1R2-like cd15067
dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...
20-323 1.41e-79

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.


Pssm-ID: 320195 [Multi-domain]  Cd Length: 262  Bit Score: 245.34  E-value: 1.41e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVIlmaILGNLLVMVAVCRDRQLRKIkTNYFIVSLAFADLLVSVLVMPFGAI-ELVQDIWFYGEMFCLVRTS 98
Cdd:cd15067     3 GVVLSLFCLVT---VAGNLLVILAVLRERYLRTV-TNYFIVSLAVADLLVGSIVMPFSILhEMTGGYWLFGRDWCDVWHS 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  99 LDVLLTTASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVIPMFISFlPIMQGWNNIGivdviekrkfNHN 178
Cdd:cd15067    79 FDVLASTASILNLCVISLDRYWAI-TDPISYPSRMTKRRALIMIALVWICSALISF-PAIAWWRAVD----------PGP 146
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 179 SNSTFCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTA-KEHaqqiqmlqragatsesrpqtadqhsthrmrtetKA 257
Cdd:cd15067   147 SPPNQCLFTDDSGYLIFSSCVSFYIPLVVMLFTYYRIYRAAaKEQ---------------------------------KA 193
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1938531436 258 AKTLCVIMGCFCFCWAPFFVTNIVDPF-IDYTV--PEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15067   194 AKTLGIVMGVFILCWLPFFVTNILIGFcPSNCVsnPDILFPLVTWLGYINSGMNPIIYACSSRDFRRAF 262
7tmA_Beta_AR cd15058
beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...
20-323 2.27e-77

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320186 [Multi-domain]  Cd Length: 305  Bit Score: 241.20  E-value: 2.27e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIkTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSL 99
Cdd:cd15058     1 PGLLLLLALIILAIVVGNLLVIIAIARTSRLQTM-TNIFITSLACADLVMGLLVVPLGATIVVTGKWQLGNFWCELWTSV 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 100 DVLLTTASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMQGWNNigivdVIEKRKFNHNS 179
Cdd:cd15058    80 DVLCVTASIETLCVIAVDRYIAI-TRPLRYQVLLTKRRARVIVCVVWIVSALVSFVPIMNQWWR-----ANDPEANDCYQ 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 180 NSTFCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAQQIQMLQRAGATSESRPQTADQHSTHRMRT------ 253
Cdd:cd15058   154 DPTCCDFRTNMAYAIASSVVSFYIPLLIMIFVYARVFLIATRQLQLIDKRRLRFQSECPAPQTTSPEGKRSSGRrpsrlt 233
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1938531436 254 ---ETKAAKTLCVIMGCFCFCWAPFFVTNIVDPFIDYTVPEKVWTAFLWLGYINSGLNPFLYAFlNKSFRRAF 323
Cdd:cd15058   234 vvkEHKALKTLGIIMGTFTLCWLPFFIANIINVFNRNLPPGEVFLLLNWLGYINSGLNPIIYCR-SPEFRTAF 305
7tmA_5-HT7 cd15329
serotonin receptor subtype 7, member of the class A family of seven-transmembrane G ...
20-323 4.17e-76

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT7 receptor, one of 14 mammalian serotonin receptors, is a member of the class A of GPCRs and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT7 receptor mainly couples to Gs protein, which positively stimulates adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. 5-HT7 receptor is expressed in various human tissues, mainly in the brain, the lower gastrointestinal tract and in vital blood vessels including the coronary artery. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320452 [Multi-domain]  Cd Length: 260  Bit Score: 236.40  E-value: 4.17e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRkIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSL 99
Cdd:cd15329     1 VLIGIVLLIIILGTVVGNALVIIAVCLVKKLR-TPSNYLIVSLAVSDLLVALLVMPLAIIYELSGYWPFGEILCDVWISF 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 100 DVLLTTASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVIPMFISfLPIMQGWNnigivdviekrkfNHNS 179
Cdd:cd15329    80 DVLLCTASILNLCAISVDRYLVI-TRPLTYAVKRTPKRMALMIAIVWLLSALIS-IPPLFGWK-------------NKVN 144
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 180 NSTFCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEhaqqiqmlqragatsesrpqtadqhsthrmrtETKAAK 259
Cdd:cd15329   145 DPGVCQVSQDFGYQIYATFGAFYIPLIVMLVLYYKIYRAAKS--------------------------------ERKAIK 192
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1938531436 260 TLCVIMGCFCFCWAPFFVTNIVDPFI----DYTVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15329   193 TLGIIMGAFTLCWLPFFILALLRPFLkpikCSCIPLWLSRLFLWLGYANSFLNPIIYAKFNREFRTPF 260
7tmA_5-HT1_5_7 cd15064
serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...
20-323 2.01e-75

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320192 [Multi-domain]  Cd Length: 258  Bit Score: 234.53  E-value: 2.01e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIkTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSL 99
Cdd:cd15064     1 VLISVLLSLIILATILGNALVIAAILLTRKLHTP-ANYLIASLAVADLLVAVLVMPLSAVYELTGRWILGQVLCDIWISL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 100 DVLLTTASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMQGWNNigivDVIEKRKfnhns 179
Cdd:cd15064    80 DVTCCTASILHLCVIALDRYWAI-TDAVEYAHKRTPKRAAVMIALVWTLSICISLPPLFGWRTP----DSEDPSE----- 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 180 nstfCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEhaqqiqmlqragatsesrpqtadqhsthrmrtETKAAK 259
Cdd:cd15064   150 ----CLISQDIGYTIFSTFGAFYIPLLLMLILYWKIYRAAAR--------------------------------ERKAAK 193
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1938531436 260 TLCVIMGCFCFCWAPFFVTNIVDPFIDY-TVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15064   194 TLGIILGAFIVCWLPFFLVALIVPLCSHcWIPLALKSFFLWLGYFNSLINPLIYTFFNKDFRKAF 258
7tmA_D1A_dopamine_R cd15320
D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
19-323 3.85e-73

D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320443 [Multi-domain]  Cd Length: 319  Bit Score: 230.66  E-value: 3.85e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  19 KVVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEmFCLVRTS 98
Cdd:cd15320     1 RVLTGCFLSVLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGS-FCNIWVA 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  99 LDVLLTTASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMQGWNNIGIVDVIEKRKFNHN 178
Cdd:cd15320    80 FDIMCSTASILNLCVISVDRYWAI-SSPFRYERKMTPKVAFIMISVAWTLSVLISFIPVQLNWHKAKPTSFLDLNASLRD 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 179 SNSTFCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAQQIQMLQRAGATSESRPQTA---------DQHSTH 249
Cdd:cd15320   159 LTMDNCDSSLNRTYAISSSLISFYIPVAIMIVTYTRIYRIAQKQIRRISALERAAVHAKNCQNSTgnrgsgdcqQPESSF 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 250 RM--RTETKAAKTLCVIMGCFCFCWAPFFVTNIVDPFIDYTVPE------KVWTAFLWLGYINSGLNPFLYAFlNKSFRR 321
Cdd:cd15320   239 KMsfKRETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCKPTSTEpfcissTTFDVFVWFGWANSSLNPIIYAF-NADFRK 317

                  ..
gi 1938531436 322 AF 323
Cdd:cd15320   318 AF 319
7tmA_TAAR5-like cd15317
trace amine-associated receptor 5 and similar receptors, member of the class A family of ...
20-323 2.86e-72

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320440 [Multi-domain]  Cd Length: 290  Bit Score: 227.72  E-value: 2.86e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKiKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSL 99
Cdd:cd15317     1 VIIYIVLVLAMLITVSGNLVVIISISHFKQLHS-PTNMLVLSLATADFLLGLCVMPFSMIRTVETCWYFGDLFCKFHTGL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 100 DVLLTTASIFHLCCISLDRYYAICcQPLVYRNKMTpLRIALML-GGCWVIPMFISFLPIMQGWNNIGIVDVIEKRkfnhn 178
Cdd:cd15317    80 DLLLCTTSIFHLCFIAIDRYYAVC-DPLRYPSKIT-VQVAWRFiAIGWLVPGIYTFGLIYTGANDEGLEEYSSEI----- 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 179 SNSTFCVFMVNKPYAITCSVVaFYIPFLLMVLAYYRIYVTAKEHAQQIQMLQRAGATSESRPQTADQHSTHrmrtetKAA 258
Cdd:cd15317   153 SCVGGCQLLFNKIWVLLDFLT-FFIPCLIMIGLYAKIFLVARRQARKIQNMEDKFRSSEENSSKASASRER------KAA 225
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1938531436 259 KTLCVIMGCFCFCWAPFFVTNIVDPFIDYTVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15317   226 KTLAIVMGIFLFCWLPYFIDTIVDEYSNFITPAIVFDAVIWLGYFNSAFNPFIYAFFYPWFRKAF 290
7tmA_tyramine_R-like cd15061
tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
21-323 1.47e-70

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine-specific receptors and similar proteins found in insects and other invertebrates. These tyramine receptors form a distinct receptor family that is phylogenetically different from the other tyramine/octopamine receptors which also found in invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320189 [Multi-domain]  Cd Length: 256  Bit Score: 221.85  E-value: 1.47e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  21 VLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIkTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSLD 100
Cdd:cd15061     1 ILISFLILAIIFTIFGNLLVILAVATTRRLRTI-TNCYIVSLATADLLVGVLVLPLAIIRQLLGYWPLGSHLCDFWISLD 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 101 VLLTTASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMqGWNNIGIVDVIEkrkfnhnsn 180
Cdd:cd15061    80 VLLCTASILNLCCISLDRYFAI-TYPLKYRTKRSRRLAITMILAVWVISLLITSPPLV-GPSWHGRRGLGS--------- 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 181 stfCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKehaqqiqmlqragatsesrpqtadqhsthrmrTETKAAKT 260
Cdd:cd15061   149 ---CYYTYDKGYRIYSSMGSFFLPLLLMLFVYLRIFRVIA--------------------------------KERKTAKT 193
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1938531436 261 LCVIMGCFCFCWAPFFVTNIVDPFIDYTVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15061   194 LAIVVGCFIVCWLPFFIMYLIEPFCDCQFSEALSTAFTWLGYFNSVINPFIYAFYNKDFRRAF 256
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
22-316 1.11e-68

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 217.93  E-value: 1.11e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  22 LLTFFAMVILMAILGNLLVMVAVCRDRQLRKIkTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSLDV 101
Cdd:cd00637     1 LAVLYILIFVVGLVGNLLVILVILRNRRLRTV-TNYFILNLAVADLLVGLLVIPFSLVSLLLGRWWFGDALCKLLGFLQS 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 102 LLTTASIFHLCCISLDRYYAICCqPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMqGWNNIGIVDVIEKRKFnhnsns 181
Cdd:cd00637    80 VSLLASILTLTAISVDRYLAIVH-PLRYRRRFTRRRAKLLIALIWLLSLLLALPPLL-GWGVYDYGGYCCCCLC------ 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 182 tFCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAQQIqmlqragatsesRPQTADQHSTHRMRTETKAAKTL 261
Cdd:cd00637   152 -WPDLTLSKAYTIFLFVLLFLLPLLVIIVCYVRIFRKLRRHRRRI------------RSSSSNSSRRRRRRRERKVTKTL 218
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1938531436 262 CVIMGCFCFCWAPFFVTNIVDPF--IDYTVPEKVWTAFLWLGYINSGLNPFLYAFLN 316
Cdd:cd00637   219 LIVVVVFLLCWLPYFILLLLDVFgpDPSPLPRILYFLALLLAYLNSAINPIIYAFFN 275
7tmA_Octopamine_R cd15063
octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...
20-323 4.68e-68

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.


Pssm-ID: 320191 [Multi-domain]  Cd Length: 266  Bit Score: 215.82  E-value: 4.68e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIkTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSL 99
Cdd:cd15063     1 LISLLVLTFLNVLVVLGNLLVIAAVLCSRKLRTV-TNLFIVSLACADLLVGTLVLPFSAVNEVLDVWIFGHTWCQIWLAV 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 100 DVLLTTASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMqGWNNIGivDVIEKRKFNHNS 179
Cdd:cd15063    80 DVWMCTASILNLCAISLDRYLAI-TRPIRYPSLMSTKRAKCLIAGVWVLSFVICFPPLV-GWNDGK--DGIMDYSGSSSL 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 180 NSTfCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAkehaqqiqmlqragatsesrpqtadqhsthrmRTETKAAK 259
Cdd:cd15063   156 PCT-CELTNGRGYVIYSALGSFYIPMLVMLFFYFRIYRAA--------------------------------RMETKAAK 202
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1938531436 260 TLCVIMGCFCFCWAPFFVTNIVDPFIDYTVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15063   203 TVAIIVGCFIFCWLPFFTVYLVRAFCEDCIPPLLFSVFFWLGYCNSALNPCIYALFSRDFRFAF 266
7tmA_D1B_dopamine_R cd15319
D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
20-323 7.06e-68

D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320442 [Multi-domain]  Cd Length: 317  Bit Score: 217.13  E-value: 7.06e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGeMFCLVRTSL 99
Cdd:cd15319     1 VVTGCLLSLLILWTLLGNILVCAAVVRFRHLRSKVTNIFIVSLAVSDLFVALLVMPWKAVAEVAGYWPFG-AFCDVWVAF 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 100 DVLLTTASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMQGWNNIGIVDVIEKRKFN-HN 178
Cdd:cd15319    80 DIMCSTASILNLCVISVDRYWAI-SSPFRYERKMTQRVALVMISVAWTLSVLISFIPVQLNWHKDSGDDWVGLHNSSiSR 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 179 SNSTFCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAQQIQMLQRAGATSES-RPQTADQHSTHRMRT---- 253
Cdd:cd15319   159 QVEENCDSSLNRTYAISSSLISFYIPVAIMIVTYTRIYRIAQIQIRRISSLERAAEHAQScRSNRIDCHHHTSLRTsikk 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 254 ETKAAKTLCVIMGCFCFCWAPFFVTNIVDPFIDYT----------VPEKVWTAFLWLGYINSGLNPFLYAFlNKSFRRAF 323
Cdd:cd15319   239 ETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCDRPpadpdaglpcVSETTFDVFVWFGWANSSLNPIIYAF-NADFRKVF 317
7tmA_Beta1_AR cd15958
beta-1 adrenergic receptors (adrenoceptors), member of the class A family of ...
25-323 9.81e-66

beta-1 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-1 adrenergic receptor (beta-1 adrenoceptor), also known as beta-1 AR, is activated by adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320624 [Multi-domain]  Cd Length: 298  Bit Score: 210.91  E-value: 9.81e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  25 FFAMVILMAILGNLLVMVAVCRDRQLRKIkTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSLDVLLT 104
Cdd:cd15958     6 LMALIVLLIVAGNVLVIVAIGRTQRLQTL-TNLFITSLACADLVMGLLVVPFGATLVVRGRWLYGSFFCELWTSVDVLCV 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 105 TASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMQGWNNIGivDVIEKRKFNhnsNSTFC 184
Cdd:cd15958    85 TASIETLCVIAIDRYLAI-TSPFRYQSLLTRARAKGIVCTVWAISALVSFLPIMMHWWRDE--DDQALKCYE---DPGCC 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 185 VFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAQQIQMLQRAGATSESRPQTADQHSTHRMRT--ETKAAKTLC 262
Cdd:cd15958   159 DFVTNRAYAIASSIISFYIPLLIMIFVYLRVYREAKKQIKKIDKCEGRFHNTLTGLGRKCKRRPSRILAlrEQKALKTLG 238
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1938531436 263 VIMGCFCFCWAPFFVTNIVDPFIDYTVPEKVWTAFLWLGYINSGLNPFLYAfLNKSFRRAF 323
Cdd:cd15958   239 IIMGVFTLCWLPFFLVNVVNVFNRELVPDWLFVFFNWLGYANSAFNPIIYC-RSPDFRKAF 298
7tmA_Beta3_AR cd15959
beta-3 adrenergic receptors (adrenoceptors), member of the class A family of ...
26-323 2.83e-65

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-3 adrenergic receptor (beta-3 adrenoceptor), also known as beta-3 AR, is activated by adrenaline and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320625 [Multi-domain]  Cd Length: 302  Bit Score: 209.76  E-value: 2.83e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  26 FAMVILMAILGNLLVMVAVCRDRQLRKIkTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSLDVLLTT 105
Cdd:cd15959     7 LSLAILVIVGGNLLVIVAIAKTPRLQTM-TNVFVTSLACADLVMGLLVVPPGATILLTGHWPLGTTVCELWTSVDVLCVT 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 106 ASIFHLCCISLDRYYAICcQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMQGWNNIGiVDVIEKRKFnhnSNSTFCV 185
Cdd:cd15959    86 ASIETLCAIAVDRYLAIT-NPLRYEALVTKRRARTAVCLVWAISAAISFLPIMNQWWRDG-ADEEAQRCY---DNPRCCD 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 186 FMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAQQI-----QMLQRAGATSESRPQTADQHSTHRMRTETKAAKT 260
Cdd:cd15959   161 FVTNMPYAIVSSTVSFYVPLLVMIFVYVRVFVVATRQVRLIrkdkvRFPPEESPPAESRPACGRRPSRLLAIKEHKALKT 240
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1938531436 261 LCVIMGCFCFCWAPFFVTNIVDPFIDYTVPEKVWTAFLWLGYINSGLNPFLYAfLNKSFRRAF 323
Cdd:cd15959   241 LGIIMGTFTLCWLPFFVANIIKVFCRSLVPDPAFLFLNWLGYANSAFNPIIYC-RSPDFRSAF 302
7tmA_D2-like_dopamine_R cd15053
D2-like dopamine receptors, member of the class A family of seven-transmembrane G ...
25-323 2.05e-64

D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320181 [Multi-domain]  Cd Length: 263  Bit Score: 206.43  E-value: 2.05e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  25 FFAMVILMAILGNLLVMVAVCRDRQLRKIkTNYFIVSLAFADLLVSVLVMPFGAIELVQD-IWFYGEMFCLVRTSLDVLL 103
Cdd:cd15053     6 FLLLLPLLTVFGNVLVIMSVFRERSLQTA-TNYFIVSLAVADLLVAILVMPFAVYVEVNGgKWYLGPILCDIYIAMDVMC 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 104 TTASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVIPMFISfLPIMQGWNNIGivdviekrkfnhNSNSTF 183
Cdd:cd15053    85 STASIFNLCAISIDRYIAV-TQPIKYARQKNSKRVLLTIAIVWVVSAAIA-CPLLFGLNNVP------------YRDPEE 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 184 CVFMvNKPYAITCSVVAFYIPFLLMVLAYYRIYVtakehaqqiqmlqragatsesrpqtadqhsthRMRTETKAAKTLCV 263
Cdd:cd15053   151 CRFY-NPDFIIYSSISSFYIPCIVMLLLYYRIFR--------------------------------ALRREKKATKTLAI 197
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1938531436 264 IMGCFCFCWAPFFVTNIVDPFIDYT------VPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15053   198 VLGVFLFCWLPFFTLNILNAICPKLqnqschVGPALFSLTTWLGYVNSFLNPIIYTIFNIEFRKAF 263
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
36-312 5.77e-63

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 202.53  E-value: 5.77e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  36 GNLLVMVAVCRDRQLRKIkTNYFIVSLAFADLLVSVLVMPFGAIELVQDI-WFYGEMFCLVRTSLDVLLTTASIFHLCCI 114
Cdd:pfam00001   1 GNLLVILVILRNKKLRTP-TNIFLLNLAVADLLFSLLTLPFWLVYYLNHGdWPFGSALCKIVGALFVVNGYASILLLTAI 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 115 SLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMQGWNNigivdviekrkFNHNSNSTFCVFMVNKP--- 191
Cdd:pfam00001  80 SIDRYLAI-VHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFGWTL-----------TVPEGNVTVCFIDFPEDlsk 147
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 192 ---YAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAQQiqmlqragatsesrpqtadQHSTHRMRTETKAAKTLCVIMGCF 268
Cdd:pfam00001 148 pvsYTLLISVLGFLLPLLVILVCYTLIIRTLRKSASK-------------------QKSSERTQRRRKALKTLAVVVVVF 208
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1938531436 269 CFCWAPFFVTNIVDPFIDYTVPE----KVWTAFLWLGYINSGLNPFLY 312
Cdd:pfam00001 209 ILCWLPYHIVNLLDSLALDCELSrlldKALSVTLWLAYVNSCLNPIIY 256
7tmA_tyramine_octopamine_R-like cd15060
tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G ...
20-323 1.19e-61

tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine/octopamine receptors and similar proteins found in insects and other invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320188 [Multi-domain]  Cd Length: 260  Bit Score: 199.19  E-value: 1.19e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIKtNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSL 99
Cdd:cd15060     1 VVTTILLSVIIAFTIVGNILVILSVFTYRPLRIVQ-NFFIVSLAVADLAVAIFVLPLNVAYFLLGKWLFGIHLCQMWLTC 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 100 DVLLTTASIFHLCCISLDRYYAICcQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMqGWNNIGivdviekrkfNHNS 179
Cdd:cd15060    80 DILCCTASILNLCAIALDRYWAIH-DPINYAQKRTLKRVLLMIVVVWALSALISVPPLI-GWNDWP----------ENFT 147
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 180 NSTFCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVtakehaqqiqmlqragATSESRpqtadqhsthrmrtetKAAK 259
Cdd:cd15060   148 ETTPCTLTEEKGYVIYSSSGSFFIPLLIMTIVYVKIFI----------------ATSKER----------------RAAR 195
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1938531436 260 TLCVIMGCFCFCWAPFFVTNIVDPFIDYTVP-EKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15060   196 TLGIIMGVFVVCWLPFFLMYVILPFCETCSPsAKVVNFITWLGYVNSALNPVIYTIFNLDFRRAF 260
7tmA_alpha2_AR cd15059
alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G ...
28-323 1.20e-60

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320187 [Multi-domain]  Cd Length: 261  Bit Score: 196.41  E-value: 1.20e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  28 MVILMAILGNLLVMVAVCRDRQLRKIKtNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSLDVLLTTAS 107
Cdd:cd15059     9 VVILLIIVGNVLVIVAVLTSRKLRAPQ-NWFLVSLAVADILVGLLIMPFSLVNELMGYWYFGSVWCEIWLALDVLFCTAS 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 108 IFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMqGWnnigivdvieKRKFNHNSNSTFCVFM 187
Cdd:cd15059    88 IVNLCAISLDRYWSV-TQAVEYNLKRTPRRAKAMIAAVWIISAVISLPPLF-GW----------KDEQPWHGAEPQCELS 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 188 VNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKehaqqiqmlqragatsesrpqtadqhsthrmRTETKAAKTLCVIMGC 267
Cdd:cd15059   156 DDPGYVLFSSIGSFYIPLLIMIIVYARIYRAAK-------------------------------RKERRFTLVLGVVMGA 204
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1938531436 268 FCFCWAPFFVTNIVDPF-IDYTVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15059   205 FVLCWLPFFFTYPLVVVcKTCGVPELLFKFFFWLGYCNSALNPVIYTIFNKDFRRAF 261
7tmA_Beta2_AR cd15957
beta-2 adrenergic receptors (adrenoceptors), member of the class A family of ...
27-323 2.37e-60

beta-2 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; Beta-2 AR is activated by adrenaline that plays important roles in cardiac function and pulmonary physiology. While beta-1 AR and beta-2 AR are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway, beta-2 AR can couple to both G(s) and G(i) proteins in the heart. Moreover, beta-2 AR activation leads to smooth muscle relaxation and bronchodilation in the lung. The beta adrenergic receptors are a subfamily of the class A rhodopsin-like G protein-coupled receptors.


Pssm-ID: 341355 [Multi-domain]  Cd Length: 301  Bit Score: 197.01  E-value: 2.37e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  27 AMVILMAILGNLLVMVAVCRDRQLRKIkTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSLDVLLTTA 106
Cdd:cd15957     8 SLIVLAIVFGNVLVITAIAKFERLQTV-TNYFITSLACADLVMGLAVVPFGAAHILLKTWTFGNFWCEFWTSIDVLCVTA 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 107 SIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMQGWNNigivdVIEKRKFNHNSNSTFCVF 186
Cdd:cd15957    87 SIETLCVIAVDRYFAI-TSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYR-----ATHQEAINCYAEETCCDF 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 187 MVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAQQIQMLQ-RAGATSESRPQTADQHSTHRMRT----ETKAAKTL 261
Cdd:cd15957   161 FTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKSEgRFHNQNIDQNGSGGGGGNRRRSKfclkEHKALKTL 240
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1938531436 262 CVIMGCFCFCWAPFFVTNIVDPFIDYTVPEKVWTAFLWLGYINSGLNPFLYAfLNKSFRRAF 323
Cdd:cd15957   241 GIIMGTFTLCWLPFFIVNIVHVIQDNLIRKEVYILLNWIGYVNSGFNPLIYC-RSPDFRIAF 301
7tmA_5-HT2 cd15052
serotonin receptor subtype 2, member of the class A family of seven-transmembrane G ...
25-323 2.32e-59

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320180 [Multi-domain]  Cd Length: 262  Bit Score: 193.30  E-value: 2.32e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  25 FFAMVILMAILGNLLVMVAVCRDRQLRKIkTNYFIVSLAFADLLVSVLVMPFGAI-ELVQDIWFYGEMFCLVRTSLDVLL 103
Cdd:cd15052     6 LLLLLVIATIGGNILVCLAISLEKRLQNV-TNYFLMSLAIADLLVGLLVMPLSILtELFGGVWPLPLVLCLLWVTLDVLF 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 104 TTASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVIPMFISF-LPIMqgwnniGIVDviEKRKFNHNSnst 182
Cdd:cd15052    85 CTASIMHLCTISLDRYMAI-RYPLRTRRNKSRTTVFLKIAIVWLISIGISSpIPVL------GIID--TTNVLNNGT--- 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 183 fCVfMVNKPYAITCSVVAFYIPFLLMVLAYYRiyvtakehaqqiqmlqragatsesrpqtadqhSTHRMRTETKAAKTLC 262
Cdd:cd15052   153 -CV-LFNPNFVIYGSIVAFFIPLLIMVVTYAL--------------------------------TIRLLSNEQKASKVLG 198
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1938531436 263 VIMGCFCFCWAPFFVTNIVDPFIDY---TVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15052   199 IVFAVFVICWCPFFITNILTGLCEEcncRISPWLLSVFVWLGYVSSTINPIIYTIFNKTFRRAF 262
7tmA_5-HT1A_invertebrates cd15331
serotonin receptor subtype 1A from invertebrates, member of the class A family of ...
20-323 2.41e-59

serotonin receptor subtype 1A from invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320454 [Multi-domain]  Cd Length: 261  Bit Score: 193.34  E-value: 2.41e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIkTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSL 99
Cdd:cd15331     1 VLTSIILGLLILATIIGNVFVIAAILLERSLQGV-SNYLILSLAVADLMVAVLVMPLSAVYEVSQHWFLGPEVCDMWISM 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 100 DVLLTTASIFHLCCISLDRYYAICCqpLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMqGWNNIGIVDVIEKRKfnhns 179
Cdd:cd15331    80 DVLCCTASILHLVAIALDRYWAVTN--IDYIRRRTAKRILIMIAVVWFVSLIISIAPLF-GWKDEDDLDRVLKTG----- 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 180 nstFCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEhaqqiqmlqragatsesrpqtadqhsthrmrtETKAAK 259
Cdd:cd15331   152 ---VCLISQDYGYTIFSTVGAFYVPLLLMIIIYWKIYQAAKR--------------------------------ERKAAR 196
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1938531436 260 TLCVIMGCFCFCWAPFFVTNIVDPFI-DYTVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15331   197 TLAIITGAFVVCWLPFFLVALVMPFCgAWQISRFLESFFLWLGYFNSLLNPIIYTIFSPDFRGAF 261
7tmA_mAChR cd15049
muscarinic acetylcholine receptor subfamily, member of the class A family of ...
27-323 3.33e-57

muscarinic acetylcholine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341322 [Multi-domain]  Cd Length: 262  Bit Score: 187.53  E-value: 3.33e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  27 AMVILMAILGNLLVMVAVCRDRQLRKIkTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSLDVLLTTA 106
Cdd:cd15049     8 GSLSLVTVGGNILVILSFRVNRQLRTV-NNYFLLSLACADLIIGLVSMNLYTVYLVMGYWPLGPLLCDLWLALDYVASNA 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 107 SIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMqGWNNI-GIVDVIEKRkfnhnsnsTFCV 185
Cdd:cd15049    87 SVMNLLLISFDRYFSV-TRPLTYRAKRTPKRAILMIALAWVISFVLWAPAIL-GWQYFvGERTVPDGQ--------CYIQ 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 186 FMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAkehaqqiqmlqragatsesrpqtadqhsthrmRTETKAAKTLCVIM 265
Cdd:cd15049   157 FLDDPAITFGTAIAAFYLPVLVMTILYWRIYRET--------------------------------ARERKAARTLSAIL 204
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1938531436 266 GCFCFCWAPFFVTNIVDPFIDYTVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15049   205 LAFIITWTPYNILVLVSTFCAKCIPDTLWSFGYWLCYINSTINPFCYALCNKTFRKTF 262
7tmA_Histamine_H3R_H4R cd15048
histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G ...
20-323 7.43e-57

histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H4R, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320176 [Multi-domain]  Cd Length: 296  Bit Score: 187.90  E-value: 7.43e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIkTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSL 99
Cdd:cd15048     1 IVLAVLISVLILVTVIGNLLVILAFIKDKKLRTV-SNFFLLNLAVADFLVGLVSMPFYIPYTLTGKWPFGKVFCKAWLVV 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 100 DVLLTTASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVIpMFISFLPIMQGWNNIGIVDVIEkrkfnhnS 179
Cdd:cd15048    80 DYTLCTASALTIVLISLDRYLSV-TKAVKYRAKQTKRRTVLLMALVWIL-AFLLYGPAIIGWDLWTGYSIVP-------T 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 180 NSTFCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAQQIQMLQRAGATSESRPQTA-DQHSTHRMRTETKAA 258
Cdd:cd15048   151 GDCEVEFFDHFYFTFITSVLEFFIPFISVSFFNLLIYLNIRKRSRRRPLRSVPILPASQNPSRArSQREQVKLRRDRKAA 230
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1938531436 259 KTLCVIMGCFCFCWAPFFVTNIVDPFI-DYTVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15048   231 KSLAILVLVFLICWAPYTILTIIRSFCsGSCVDSYLYEFTFWLLWTNSAINPFLYAACHPRFRKAF 296
7tmA_5-HT1A_vertebrates cd15330
serotonin receptor subtype 1A from vertebrates, member of the class A family of ...
25-323 1.12e-56

serotonin receptor subtype 1A from vertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320453 [Multi-domain]  Cd Length: 260  Bit Score: 186.34  E-value: 1.12e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  25 FFAMVILMAILGNLLVMVAVCRDRQLRKIkTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSLDVLLT 104
Cdd:cd15330     6 FLGTLILCAIFGNACVVAAIALERSLQNV-ANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCC 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 105 TASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVIPMFISfLPIMQGWnnigivdviekRKFNHNSNSTFC 184
Cdd:cd15330    85 TSSILHLCAIALDRYWAI-TDPIDYVNKRTPRRAAVLISLTWLIGFSIS-IPPMLGW-----------RTPEDRSDPDAC 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 185 VFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEhaqqiqmlqragatsesrpqtadqhsthrmrtETKAAKTLCVI 264
Cdd:cd15330   152 TISKDPGYTIYSTFGAFYIPLILMLVLYGRIFKAAAR--------------------------------ERKTVKTLGII 199
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1938531436 265 MGCFCFCWAPFFVTNIVDPFIDYT--VPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15330   200 MGTFILCWLPFFIVALVLPFCESTchMPELLGAIINWLGYSNSLLNPIIYAYFNKDFQSAF 260
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
20-323 1.16e-55

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 184.73  E-value: 1.16e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIkTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSL 99
Cdd:cd14993     1 IVLIVLYVVVFLLALVGNSLVIAVVLRNKHMRTV-TNYFLVNLAVADLLVSLFCMPLTLLENVYRPWVFGEVLCKAVPYL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 100 DVLLTTASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVIPMFIsFLPIMqgwnnigIVDVIEKRKFNHNS 179
Cdd:cd14993    80 QGVSVSASVLTLVAISIDRYLAI-CYPLKARRVSTKRRARIIIVAIWVIAIII-MLPLL-------VVYELEEIISSEPG 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 180 NSTFCVF-------MVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTakehaqqiqmLQRaGATSESRPQTADQHSTHRMR 252
Cdd:cd14993   151 TITIYICtedwpspELRKAYNVALFVVLYVLPLLIISVAYSLIGRR----------LWR-RKPPGDRGSANSTSSRRILR 219
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1938531436 253 TETKAAKTLCVIMGCFCFCWAPFFVTNIVDPF-IDYTVPEKVWTAF-----LWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd14993   220 SKKKVARMLIVVVVLFALSWLPYYVLSILLDFgPLSSEESDENFLLilpfaQLLGYSNSAINPIIYCFMSKKFRRGF 296
7tmA_TAAR6_8_9 cd15316
trace amine-associated receptors 6, 8, and 9, member of the class A family of ...
20-322 4.88e-54

trace amine-associated receptors 6, 8, and 9, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320439 [Multi-domain]  Cd Length: 290  Bit Score: 180.44  E-value: 4.88e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKiKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSL 99
Cdd:cd15316     1 VILYIVLGFGAVLAVFGNLLVMISILHFKQLHS-PTNFLIASLACADFLVGVTVMPFSTVRSVESCWYFGESFCTFHTCC 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 100 DVLLTTASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMQGWNNIGIVDVIekrkfNHNS 179
Cdd:cd15316    80 DVSFCYASLFHLCFISVDRYIAV-TDPLVYPTKFTVSVSGICISVSWIFSLTYSFSVFYTGVNDDGLEELV-----NALN 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 180 NSTFCVFMVNKPYAITCSVVaFYIPFLLMVLAYYRIYVTAKEHAQQIQMlqragaTSESRPQTADQHSTHRMRTETKAAK 259
Cdd:cd15316   154 CVGGCQIILNQNWVLVDFLL-FFIPTFAMIILYGKIFLVAKQQARKIEM------TSSKAESSSESYKDRVARRERKAAK 226
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1938531436 260 TLCVIMGCFCFCWAPFFVTNIVDPFIDYTVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRA 322
Cdd:cd15316   227 TLGITVIAFLVSWLPYLIDVLIDAFMNFITPPYIYEICCWCAYYNSAMNPLIYALFYPWFRKA 289
7tmA_Adenosine_R cd14968
adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...
31-323 5.43e-53

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.


Pssm-ID: 341316 [Multi-domain]  Cd Length: 285  Bit Score: 177.45  E-value: 5.43e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  31 LMAILGNLLVMVAVCRDRQLRKIkTNYFIVSLAFADLLVSVLVMPFG-AIELVQDIWFYGemfCLVRTSLDVLLTTASIF 109
Cdd:cd14968    12 VLSVLGNVLVIWAVKLNRALRTV-TNYFIVSLAVADILVGALAIPLAiLISLGLPTNFHG---CLFMACLVLVLTQSSIF 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 110 HLCCISLDRYYAICCqPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMqGWNNIGIVdviekrKFNHNSNSTFCVF--M 187
Cdd:cd14968    88 SLLAIAIDRYLAIKI-PLRYKSLVTGRRAWGAIAVCWVLSFLVGLTPMF-GWNNGAPL------ESGCGEGGIQCLFeeV 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 188 VNKPYAITCSVVAF-YIPFLLMVLAYYRIYVTAKEhaqqiQMLQRAGATSESRPQtadqhstHRMRTETKAAKTLCVIMG 266
Cdd:cd14968   160 IPMDYMVYFNFFACvLVPLLIMLVIYLRIFRVIRK-----QLRQIESLLRSRRSR-------STLQKEVKAAKSLAIILF 227
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1938531436 267 CFCFCWAPFFVTNIVDPFI-DYTVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd14968   228 LFALCWLPLHIINCITLFCpECKVPKILTYIAILLSHANSAVNPIVYAYRIRKFRQTF 285
7tmA_alpha2A_AR cd15322
alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
20-323 1.64e-52

alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320445 [Multi-domain]  Cd Length: 259  Bit Score: 175.52  E-value: 1.64e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLrKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSL 99
Cdd:cd15322     1 LTLIILVGLLMLLTVFGNVLVIIAVFTSRAL-KAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLAL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 100 DVLLTTASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPImqgwnnigivdvIEKRKFNHNS 179
Cdd:cd15322    80 DVLFCTSSIVHLCAISLDRYWSI-TQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPL------------ITIEKKSGQP 146
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 180 NSTFCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHaqqiqmlqragatsesrpqtadqhsthrmrtETKAAK 259
Cdd:cd15322   147 EGPICKINDEKWYIISSCIGSFFAPCLIMVLVYIRIYQIAKNR-------------------------------EKRFTF 195
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1938531436 260 TLCVIMGCFCFCWAPFFVTNIVDPFIDYTVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15322   196 VLAVVIGVFVICWFPFFFTYTLTAVCDCSVPETLFKFFFWFGYCNSSLNPVIYTIFNHDFRRAF 259
7tmA_GPR119_R_insulinotropic_receptor cd15104
G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member ...
27-323 1.65e-52

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR119 is activated by oleoylethanolamide (OEA), a naturally occurring bioactive lipid with hypophagic and anti-obesity effects. Immunohistochemistry and double-immunofluorescence studies revealed the predominant GPR119 localization in pancreatic polypeptide (PP)-cells of islets. In addition, GPR119 expression is elevated in islets of obese hyperglycemic mice as compared to control islets, suggesting a possible involvement of this receptor in the development of obesity and diabetes. GPR119 has a significant sequence similarity with the members of the endothelial differentiation gene family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320232 [Multi-domain]  Cd Length: 283  Bit Score: 176.02  E-value: 1.65e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  27 AMVILMAIL------GNLLVMVAVCRDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSLD 100
Cdd:cd15104     1 AAGVILAVLspliitGNLLVIVALLKLIRKKDTKSNCFLLNLAIADFLVGLAIPGLATDELLSDGENTQKVLCLLRMCFV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 101 VLLTTASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMQGwnnigivdviekrKFNHNSN 180
Cdd:cd15104    81 ITSCAASVLSLAAIAFDRYLAL-KQPLRYKQIMTGKSAGALIAGLWLYSGLIGFLPLISP-------------QFQQTSY 146
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 181 STFCVF--MVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAQQIQMLQRAGATSESRPQTAdqhsthrmrTETKAA 258
Cdd:cd15104   147 KGKCSFfaAFHPRVLLVLSCMVFFPALLLFVFCYCDILKIARVHSRAIYKVEHALARQIHPRRTL---------SDFKAA 217
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1938531436 259 KTLCVIMGCFCFCWAPFFVTNIVDPFIDYTVPEKVWTAFLW-LGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15104   218 RTVAVLIGCFLLSWLPFQITGLVQALCDECKLYDVLEDYLWlLGLCNSLLNPWIYAFWQKEVRRAL 283
7tmA_5-HT6 cd15054
serotonin receptor subtype 6, member of the class A family of seven-transmembrane G ...
25-323 1.13e-51

serotonin receptor subtype 6, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT6 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT6 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. The 5-HT6 receptors mediates excitatory neurotransmission and are involved in learning and memory; thus they are promising targets for the treatment of cognitive impairment. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320182 [Multi-domain]  Cd Length: 267  Bit Score: 173.45  E-value: 1.13e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  25 FFAMVILMAILGNLLVMVAVCRDRQLRKIkTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSLDVLLT 104
Cdd:cd15054     6 FLCLIILLTVAGNSLLILLIFTQRSLRNT-SNYFLVSLFMSDLMVGLVVMPPAMLNALYGRWVLARDFCPIWYAFDVMCC 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 105 TASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMQGWNNIGivdviekrKFNHNSNSTF- 183
Cdd:cd15054    85 SASILNLCVISLDRYLLI-ISPLRYKLRMTPPRALALILAAWTLAALASFLPIELGWHELG--------HERTLPNLTSg 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 184 -----CVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAkehaqqiqmlqragatsesrpqtadqhsthrmRTETKAA 258
Cdd:cd15054   156 tvegqCRLLVSLPYALVASCLTFFLPSGAICFTYCRILLAA--------------------------------RKALKAS 203
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1938531436 259 KTLCVIMGCFCFCWAPFFVTNIVDPFIDyTVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15054   204 LTLGILLGMFFVTWLPFFVANVVQAVCD-CVSPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRAL 267
7tmA_Histamine_H1R cd15050
histamine subtype H1 receptor, member of the class A family of seven-transmembrane G ...
20-323 3.19e-51

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H1R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). H1R selectively interacts with the G(q)-type G protein that activates phospholipase C and the phosphatidylinositol pathway. Antihistamines, a widely used anti-allergy medication, act on the H1 subtype and produce drowsiness as a side effect. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320178 [Multi-domain]  Cd Length: 263  Bit Score: 172.23  E-value: 3.19e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIkTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSL 99
Cdd:cd15050     1 APLGIALSTISLITVILNLLVLYAVRTERKLHTV-GNLYIVSLSVADLIVGAVVMPLNIVYLLESKWILGRPVCLFWLSM 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 100 DVLLTTASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVIPmFISFLPIMqGWNNIGIVDvieKRKFNHNS 179
Cdd:cd15050    80 DYVASTASIFSLFILCIDRYRSV-QQPLKYLKYRTKTRASLMISGAWLLS-FLWVIPIL-GWHHFARGG---ERVVLEDK 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 180 NSTfcVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYvtakehaqqiqmlqragatsesrpqtadqhstHRMRTETKAAK 259
Cdd:cd15050   154 CET--DFHDVTWFKVLTAILNFYIPSLLMLWFYAKIF--------------------------------KAVNRERKAAK 199
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1938531436 260 TLCVIMGCFCFCWAPFFVTNIVDPFIDYTVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15050   200 QLGFIMAAFILCWIPYFILFMVIAFCKNCCNENLHMFTIWLGYINSTLNPFIYPLCNENFKKTF 263
7tmA_D3_dopamine_R cd15310
D3 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
26-323 2.19e-50

D3 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320436 [Multi-domain]  Cd Length: 259  Bit Score: 170.15  E-value: 2.19e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  26 FAMVILMAILGNLLVMVAVCRDRQLrKIKTNYFIVSLAFADLLVSVLVMPFGA-IELVQDIWFYGEMFCLVRTSLDVLLT 104
Cdd:cd15310     7 YCALILAIVFGNVLVCMAVLRERAL-QTTTNYLVVSLAVADLLVATLVMPWVVyLEVTGGVWNFSRICCDVFVTLDVMMC 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 105 TASIFHLCCISLDRYYAIcCQPLVYRNKMTP---LRIALMLGGCWVIPMFISfLPIMQGWNNIGivdviekrkfnhnsNS 181
Cdd:cd15310    86 TASILNLCAISIDRYTAV-VMPVHYQHGTGQsscRRVSLMITAVWVLAFAVS-CPLLFGFNTTG--------------DP 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 182 TFCVfMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTakehaqqiqmlqragatsesrpqtadqhsthrMRTETKAAKTL 261
Cdd:cd15310   150 TVCS-ISNPDFVIYSSVVSFYLPFGVTLLVYVRIYVV--------------------------------LLREKKATQML 196
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1938531436 262 CVIMGCFCFCWAPFFVTNIVDPFIDYT-VPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15310   197 AIVLGAFIVCWLPFFLTHILNTHCQAChVPPELYSATTWLGYVNSALNPVIYTTFNIEFRRAF 259
7tmA_alpha1_AR cd15062
alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G ...
20-323 7.75e-50

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320190 [Multi-domain]  Cd Length: 261  Bit Score: 168.44  E-value: 7.75e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIkTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSL 99
Cdd:cd15062     1 IVVGVALGAFILFAIGGNLLVILSVACNRHLRTP-THYFIVNLAVADLLLSFTVLPFSATLEVLGYWAFGRIFCDVWAAV 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 100 DVLLTTASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMqGWnnigivdviekrKFNHNS 179
Cdd:cd15062    80 DVLCCTASIMSLCVISVDRYIGV-RYPLNYPTIVTARRATVALLIVWVLSLVISIGPLL-GW------------KEPAPA 145
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 180 NSTFCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAkehaqqiqmlqragatsesrpqtadqhstHRMRTETKAAK 259
Cdd:cd15062   146 DEQACGVNEEPGYVLFSSLGSFYLPLAIILVMYCRVYVVA-----------------------------FKFSREKKAAK 196
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1938531436 260 TLCVIMGCFCFCWAPFFVTNIVDP-FIDYTVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15062   197 TLGIVVGAFVLCWFPFFVVLPLGSlFSTLKPPEPVFKVVFWLGYFNSCLNPIIYPCSSREFKRAF 261
7tmA_alpha1B_AR cd15326
alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
30-323 1.03e-49

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320449 [Multi-domain]  Cd Length: 261  Bit Score: 168.15  E-value: 1.03e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  30 ILMAILGNLLVMVAVCRDRQLRkIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSLDVLLTTASIF 109
Cdd:cd15326    11 ILFAIVGNILVILSVVCNRHLR-IPTNYFIVNLAIADLLLSFTVLPFSATLEILGYWVFGRIFCDIWAAVDVLCCTASIL 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 110 HLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMqGWnnigivdviekrKFNHNSNSTFCVFMVN 189
Cdd:cd15326    90 SLCAISIDRYIGV-RHSLQYPTIVTRKRAILALLGVWVLSTVISIGPLL-GW------------KEPAPPDDKVCEITEE 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 190 KPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAQqiqmlqragatsesrpqtadqhsthrmrtETKAAKTLCVIMGCFC 269
Cdd:cd15326   156 PFYALFSSLGSFYIPLIVILVMYCRVYIVALKFSR-----------------------------EKKAAKTLGIVVGMFI 206
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1938531436 270 FCWAPFFVT-NIVDPFIDYTVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15326   207 LCWLPFFIAlPLGSLFSHLKPPETLFKIIFWLGYFNSCLNPIIYPCSSKEFKRAF 261
7tmA_alpha1D_AR cd15327
alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
25-323 1.30e-49

alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320450 [Multi-domain]  Cd Length: 261  Bit Score: 168.17  E-value: 1.30e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  25 FFAMVILMAILGNLLVMVAVCRDRQLRKIkTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSLDVLLT 104
Cdd:cd15327     6 FLAIFILMAIVGNILVILSVACNRHLQTV-TNYFIVNLAIADLLLSTTVLPFSATLEVLGFWAFGRVFCDIWAAVDVLCC 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 105 TASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMqGWnnigivdviekrKFNHNSNSTFC 184
Cdd:cd15327    85 TASILSLCVISVDRYVGV-KHSLKYPTIMTERKAGVILVLLWVSSMVISIGPLL-GW------------KEPPPPDESIC 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 185 VFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAQqiqmlqragatsesrpqtadqhsthrmrtETKAAKTLCVI 264
Cdd:cd15327   151 SITEEPGYALFSSLFSFYLPLMVILVMYFRVYVVALKFSR-----------------------------EKKAAKTLAIV 201
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 265 MGCFCFCWAPFFVTNIVDPFIDYTVP-EKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15327   202 VGVFILCWFPFFFVLPLGSFFPALKPsEMVFKVIFWLGYFNSCVNPIIYPCSSKEFKRAF 261
7tmA_alpha2B_AR cd15321
alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
21-323 1.22e-48

alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320444 [Multi-domain]  Cd Length: 268  Bit Score: 165.87  E-value: 1.22e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  21 VLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIKtNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSLD 100
Cdd:cd15321     8 AIAAAITFLILFTIFGNVLVIIAVLTSRSLRAPQ-NLFLVSLAAADILVATLIIPFSLANELMGYWYFRKTWCEIYLALD 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 101 VLLTTASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMQGWNNIGIVDVIEKRKFNHnsn 180
Cdd:cd15321    87 VLFCTSSIVHLCAISLDRYWSV-SRAIEYNSKRTPRRIKCIILIVWLIAAVISLPPLIYKGKQKDEQGGLPQCKLNE--- 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 181 stfcvfmvNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHaqqiqmlqragatsesrpqtadqhsthrmrtETKAAKT 260
Cdd:cd15321   163 --------EAWYILSSSIGSFFAPCLIMILVYLRIYLIAKNR-------------------------------EKRFTFV 203
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1938531436 261 LCVIMGCFCFCWAPFFVTNIVDPFIDYT--VPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15321   204 LAVVIGVFVLCWFPFFFSYSLGAICPELckVPHSLFQFFFWIGYCNSSLNPVIYTIFNQDFRRAF 268
7tmA_alpha2C_AR cd15323
alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G ...
22-323 3.26e-48

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320446 [Multi-domain]  Cd Length: 261  Bit Score: 164.34  E-value: 3.26e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  22 LLTFFAMVILMAILGNLLVMVAVCRDRQLRKIKtNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSLDV 101
Cdd:cd15323     3 LAAVVGFLIVFTIVGNVLVVIAVLTSRALRAPQ-NLFLVSLASADILVATLVMPFSLANELMGYWYFGQVWCNIYLALDV 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 102 LLTTASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMQGWNNIgIVDVIEKRKFNHNSns 181
Cdd:cd15323    82 LFCTSSIVHLCAISLDRYWSV-TQAVEYNLKRTPRRVKAIIVTVWLISAVISFPPLISMYRDP-EGDVYPQCKLNDET-- 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 182 tfcvfmvnkPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHaqqiqmlqragatsesrpqtadqhsthrmrtETKAAKTL 261
Cdd:cd15323   158 ---------WYILSSCIGSFFAPCLIMILVYIRIYRVAKAR-------------------------------EKRFTFVL 197
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1938531436 262 CVIMGCFCFCWAPFFVTNIVDPFIDYT--VPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15323   198 AVVMGVFVVCWFPFFFSYSLYGICREAceVPEPLFKFFFWIGYCNSSLNPVIYTIFNQDFRRSF 261
7tmA_alpha1A_AR cd15325
alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
20-323 4.25e-48

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320448 [Multi-domain]  Cd Length: 261  Bit Score: 163.91  E-value: 4.25e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIkTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSL 99
Cdd:cd15325     1 IVLGVILGGFILFGVLGNILVILSVACHRHLQTV-THYFIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAV 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 100 DVLLTTASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMqGWNNIGIVDviekrkfnhns 179
Cdd:cd15325    80 DVLCCTASIMSLCIISIDRYIGV-SYPLRYPSIMTERRGLLALLCVWVLSLVISIGPLF-GWKEPAPED----------- 146
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 180 nSTFCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAQqiqmlqragatsesrpqtadqhsthrmrtETKAAK 259
Cdd:cd15325   147 -ETICQITEEPGYALFSALGSFYLPLAIILVMYCRVYVVALKFSR-----------------------------EKKAAK 196
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1938531436 260 TLCVIMGCFCFCWAPFF-VTNIVDPFIDYTVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15325   197 TLGIVVGCFVLCWLPFFlVMPIGSIFPAYKPSDTVFKITFWLGYFNSCINPIIYPCSSQEFKKAF 261
7tmA_5-HT1E cd15335
serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G ...
20-323 1.18e-47

serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320457 [Multi-domain]  Cd Length: 258  Bit Score: 162.79  E-value: 1.18e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILgNLLVMVAVCRDRQLRKiKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSL 99
Cdd:cd15335     2 LIVLTLALITILTTVL-NSAVIAAICTTKKLHQ-PANYLICSLAVTDFLVAVLVMPLSITYIVMDTWTLGYFICEIWLSV 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 100 DVLLTTASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMqgWNNIGIVDVIEKRKFNHNs 179
Cdd:cd15335    80 DMTCCTCSILHLCVIALDRYWAI-TDAIEYARKRTAKRAGLMILTVWTISIFISIPPLF--WRNHHDANIPSQCIIQHD- 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 180 nstfcvfmvNKPYAITCSVVAFYIPFLLMVLAYYRIYvtakehaqqiqmlqragatsesrpqtadqhstHRMRTETKAAK 259
Cdd:cd15335   156 ---------HVIYTIYSTFGAFYIPLTLILILYYRIY--------------------------------HAASRERKAAR 194
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1938531436 260 TLCVIMGCFCFCWAPFFVTNIVDPFIDYTVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15335   195 ILGLILGAFILSWLPFFIKELIVGLSVMTVSPEVADFLTWLGYVNSLVNPLLYTSFNEDFKLAF 258
7tmA_5-HT1B_1D cd15333
serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G ...
19-323 3.02e-47

serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320455 [Multi-domain]  Cd Length: 265  Bit Score: 161.89  E-value: 3.02e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  19 KVVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKiKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTS 98
Cdd:cd15333     4 KISLAVLLALITLATTLSNAFVIATIYLTRKLHT-PANYLIASLAVTDLLVSILVMPISIVYTVTGTWTLGQVVCDIWLS 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  99 LDVLLTTASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMqgWNNIGIVDVIEKRKFNHN 178
Cdd:cd15333    83 SDITCCTASILHLCVIALDRYWAI-TDAVEYSKKRTPKRAAVMIALVWVISISISLPPFF--WRQAKAEEEVSECVVNTD 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 179 SNStfcvfmvnkpYAITCSVVAFYIPFLLMVLAYYRIYVTAkehaqqiqmlqragatsesrpqtadqhsthRMRtETKAA 258
Cdd:cd15333   160 HIL----------YTVYSTVGAFYIPTLLLIALYGRIYVEA------------------------------RAR-ERKAT 198
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1938531436 259 KTLCVIMGCFCFCWAPFFVTNIVDPFID--YTVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15333   199 KTLGIILGAFIVCWLPFFIISLVLPICKdaCWFHLAIFDFFTWLGYLNSLINPIIYTMSNEDFKQAF 265
7tmA_TAAR5 cd15318
trace amine-associated receptor 5, member of the class A family of seven-transmembrane G ...
27-322 1.27e-45

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 5 is one of the 15 identified amine-activated G protein-coupled receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320441 [Multi-domain]  Cd Length: 282  Bit Score: 158.10  E-value: 1.27e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  27 AMVILMAILGNLLVMVAVCRDRQLRKiKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSLDVLLTTA 106
Cdd:cd15318     8 AIGMLIIVLGNLFVVVTVSHFKALHT-PTNFLLLSLALADMLLGLTVLPFSTIRSVESCWYFGDSFCRLHTCLDTLFCLT 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 107 SIFHLCCISLDRYYAIcCQPLVYRNKMTpLRIALM-LGGCWVIPMFISFLPIMQgwnnigivDVIEKRkFNHNSNSTFCV 185
Cdd:cd15318    87 SIFHLCFISIDRHCAI-CDPLLYPSKFT-IRVACIfIAAGWLVPTVYTSVFLYT--------KAVEEG-LAELLTSVPCV 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 186 ----FMVNKPYAiTCSVVAFYIPFLLMVLAYYRIYVTAKEHAQQIqmlqragatsesrpqTADQHSTHRM-RTETKAAKT 260
Cdd:cd15318   156 gscqLLYNKLWG-WLNFPVFFIPCLIMIGLYVKIFIVAKRQARAI---------------ASLLSDTNGAsKRERKAAKT 219
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1938531436 261 LCVIMGCFCFCWAPFFVTNIVDPFIDYTVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRA 322
Cdd:cd15318   220 LGIAVGVYLLCWLPFTIDTMVDSLLNFITPPLLFDIIIWFAYFNSACNPLIYVFSYPWFRKA 281
7tmA_alpha-2D_AR cd15324
alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
20-323 1.31e-44

alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320447 [Multi-domain]  Cd Length: 256  Bit Score: 154.64  E-value: 1.31e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIKtNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSL 99
Cdd:cd15324     1 ALIVLVVVVIILVTIVGNVLVVVAVFTSRALRAPQ-NLFLVSLASADILVATLVIPFSLANEVMGYWYFGSTWCAFYLAL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 100 DVLLTTASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMqgwnnigivdviekrKFNHNS 179
Cdd:cd15324    80 DVLFCTSSIVHLCAISLDRYWSV-TKAVSYNLKRTPKRIKRMIAVVWVISAVISFPPLL---------------MTKHDE 143
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 180 NStfCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKehaqqiqmlqragatsesrpqtadqhsthrMRtETKAAK 259
Cdd:cd15324   144 WE--CLLNDETWYILSSCTVSFFAPGLIMILVYCKIYRVAK------------------------------MR-EKRFTF 190
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1938531436 260 TLCVIMGCFCFCWAPFFVTNIVDPFI--DYTVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15324   191 VLAVVMGVFVLCWFPFFFTYSLHAVCrkRCGIPDALFNLFFWIGYCNSSVNPIIYTIFNRDFRKAF 256
7tmA_5-HT2C cd15305
serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...
28-329 1.68e-44

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341346 [Multi-domain]  Cd Length: 275  Bit Score: 155.06  E-value: 1.68e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  28 MVILMAILGNLLVMVAVCRDRQLRKiKTNYFIVSLAFADLLVSVLVMPFGAIELVQD-IWFYGEMFCLVRTSLDVLLTTA 106
Cdd:cd15305     9 IIIILTIGGNILVIMAVSLEKKLQN-ATNFFLMSLAVADMLVGILVMPVSLIAILYDyAWPLPRYLCPIWISLDVLFSTA 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 107 SIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVIPMFISF-LPImqgwnnIGIVDviEKRKFNHNSnstfCV 185
Cdd:cd15305    88 SIMHLCAISLDRYVAI-RNPIEHSRFNSRTKAMMKIAAVWTISIGISMpIPV------IGLQD--DEKVFVNGT----CV 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 186 fmVNKP-YAITCSVVAFYIPFLLMVLAYyriyvtakehAQQIQMLQRAGAtsesrpqtadqhsthrMRTETKAAKTLCVI 264
Cdd:cd15305   155 --LNDEnFVLIGSFVAFFIPLIIMVITY----------CLTIQVLQRQQA----------------INNERRASKVLGIV 206
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1938531436 265 MGCFCFCWAPFFVTNIVDPF----IDYTVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCC 329
Cdd:cd15305   207 FFLFLIMWCPFFITNILSVLckeaCDQKLMEELLNVFVWVGYVSSGINPLVYTLFNKTYRRAFSNYIRC 275
7tmA_5-HT1F cd15334
serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G ...
20-323 1.44e-42

serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320456 [Multi-domain]  Cd Length: 259  Bit Score: 149.71  E-value: 1.44e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILgNLLVMVAVCRDRQLRKiKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSL 99
Cdd:cd15334     2 LISLTLSILALMTTAI-NSLVITAIIVTRKLHH-PANYLICSLAVTDFLVAVLVMPFSIMYIVKETWIMGQVVCDIWLSV 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 100 DVLLTTASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMqgWnnigivdviekRKFNHNS 179
Cdd:cd15334    80 DITCCTCSILHLSAIALDRYRAI-TDAVEYARKRTPKHAGIMIAVVWIISIFISMPPLF--W-----------RHQTTSR 145
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 180 NSTFCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEhaqqiqmlqragatsesrpqtadqhsthrmrtETKAAK 259
Cdd:cd15334   146 EDECIIKHDHIVFTIYSTFGAFYIPLALILILYYKIYRAATR--------------------------------ERKAAT 193
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1938531436 260 TLCVIMGCFCFCWAPFFVTNIVDPFIDYTVPEKVWTAFL-WLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15334   194 TLGLILGAFVICWLPFFVKEVIVNTCDSCYISEEMSNFLtWLGYINSLINPLIYTIFNEDFKKAF 258
7tmA_mAChR_M3 cd15299
muscarinic acetylcholine receptor subtype M3, member of the class A family of ...
19-329 1.54e-42

muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. The M3 receptor is mainly located in smooth muscle, exocrine glands and vascular endothelium. It induces vomiting in the central nervous system and is a critical regulator of glucose homeostasis by modulating insulin secretion. Generally, M3 receptor causes contraction of smooth muscle resulting in vasoconstriction and increased glandular secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320426 [Multi-domain]  Cd Length: 274  Bit Score: 149.71  E-value: 1.54e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  19 KVVLLTFFA-MVILMAILGNLLVMVAVCRDRQLRKIkTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRT 97
Cdd:cd15299     2 QVVLIAFLTgILALVTIIGNILVIVSFKVNKQLKTV-NNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  98 SLDVLLTTASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVIPmFISFLPIMQGWNNIgivdvIEKRKFnh 177
Cdd:cd15299    81 SIDYVASNASVMNLLVISFDRYFSI-TRPLTYRAKRTTKRAGVMIGLAWVIS-FVLWAPAILFWQYF-----VGKRTV-- 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 178 NSNSTFCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYvtaKEHAQqiqmlqragatsesrpqtadqhsthrmrtETKA 257
Cdd:cd15299   152 PPDECFIQFLSEPIITFGTAIAAFYLPVTIMTILYWRIY---KETIK-----------------------------EKKA 199
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1938531436 258 AKTLCVIMGCFCFCWAPFFVTNIVDPFIDYTVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCC 329
Cdd:cd15299   200 AQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTYWNLGYWLCYINSTVNPVCYALCNKTFRTTFKMLLLC 271
7tmA_OXR cd15208
orexin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
21-323 5.19e-42

orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Orexins (OXs, also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. Thus, activation of OX1R or OX2R will activate phospholipase activity and the phosphatidylinositol and calcium signaling pathways. Additionally, OX2R activation can also lead to inhibition of adenylate cyclase.


Pssm-ID: 320336 [Multi-domain]  Cd Length: 303  Bit Score: 149.46  E-value: 5.19e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  21 VLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIkTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSLD 100
Cdd:cd15208     2 VLIALYILVFIVGLVGNVLVCFAVWRNHHMRTV-TNYFIVNLSLADFLVIIICLPATLLVDVTETWFFGQVLCKIIPYLQ 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 101 VLLTTASIFHLCCISLDRYYAIcCQPLVYrnKMTPLRIALMLGGCWVIPMFISF--LPIMQGWNNIGIVDVIE--KRKFN 176
Cdd:cd15208    81 TVSVSVSVLTLSCIALDRWYAI-CHPLMF--KSTAKRARVSILIIWIVSLLIMIpqAIVMECSRVVPLANKTIllTVCDE 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 177 HNSNSTfcvfmVNKPYAITCSVVAFYIPFLLMVLAYYRIYVtaKEHAQQIqmlqrAGATSE-SRPQTADQHSTH-----R 250
Cdd:cd15208   158 RWSDSI-----YQKVYHICFFLVTYLLPLCLMILAYFQIFR--KLWCRQI-----PGTSSVvQRKWNKPRKSAVaaeekQ 225
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1938531436 251 MRTETKAAKTLCVIMGCFCFCWAPFFVTNIVDPFI--DYTVPEKVWTAFL---WLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15208   226 LRSRRKTAKMLIVVVIMFAICYLPVHLLNILRYVFglFTVDRETIYAWFLfshWLVYANSAINPIIYNFMSGKFREEF 303
7tmA_5-HT5 cd15328
serotonin receptor subtype 5, member of the class A family of seven-transmembrane G ...
20-323 8.34e-42

serotonin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; 5-HT5 receptor, one of 14 mammalian 5-HT receptors, is activated by the neurotransmitter and peripheral signal mediator serotonin (also known as 5-hydroxytryptamine or 5-HT). The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/0) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320451 [Multi-domain]  Cd Length: 259  Bit Score: 147.40  E-value: 8.34e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIKTNyFIVSLAFADLLVSVLVMPFGAI-ELVQDIWFYGEMFCLVRTS 98
Cdd:cd15328     1 VLVLTLLAMLVVATFLWNLLVLVTILRVRTFHRVPHN-LVASMAVSDVLVAALVMPLSLVhELSGRRWQLGRSLCQVWIS 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  99 LDVLLTTASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMQGWNNigivdviekrkfNHN 178
Cdd:cd15328    80 FDVLCCTASIWNVTAIALDRYWSI-TRHLEYTLRTRRRISNVMIALTWALSAVISLAPLLFGWGE------------TYS 146
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 179 SNSTFCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEhaqqiqmlqragatsesrpqtadqhsthrmrtETKAA 258
Cdd:cd15328   147 EDSEECQVSQEPSYTVFSTFGAFYLPLCVVLFVYWKIYKAAQK--------------------------------EKRAA 194
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1938531436 259 KTLCVIMGCFCFCWAPFFVTNIVDPFIDYTVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15328   195 LMVGILIGVFVLCWIPFFLTELISPLCSCDIPPIWKSIFLWLGYSNSFFNPLIYTAFNKNYNNAF 259
7tmA_5-HT2B cd15306
serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G ...
28-330 9.62e-42

serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341347 [Multi-domain]  Cd Length: 277  Bit Score: 148.06  E-value: 9.62e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  28 MVILMAILGNLLVMVAVCRDRQLRKiKTNYFIVSLAFADLLVSVLVMPFGAIELVQD-IWFYGEMFCLVRTSLDVLLTTA 106
Cdd:cd15306     9 MVIIPTIGGNILVILAVSLEKKLQY-ATNYFLMSLAVADLLVGLFVMPIALLTILFEaMWPLPLVLCPIWLFLDVLFSTA 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 107 SIFHLCCISLDRYYAI--CCQPLVYRNKMTP-LRIALMlggcWVIPMFISF-LPIMqgwnniGIVDviekrkFNHNSNST 182
Cdd:cd15306    88 SIMHLCAISLDRYIAIkkPIQASQYNSRATAfIKITVV----WLISIGIAIpVPIK------GIET------DVDNPNNI 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 183 FCVFMVN--KPYAITCSVVAFYIPFLLMVLAYYriyvtakehaQQIQMLQRAGATSESRpqtadqhsthrmrtetkAAKT 260
Cdd:cd15306   152 TCVLTKErfGDFILFGSLAAFFTPLAIMIVTYF----------LTIHALRKQTITNEQR-----------------ASKV 204
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1938531436 261 LCVIMGCFCFCWAPFFVTNIVDPF---IDYTVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCD 330
Cdd:cd15306   205 LGIVFFLFLLMWCPFFITNITSVLcdsCNQTTLQMLMEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRYITCN 277
7tmA_D2_dopamine_R cd15309
D2 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
25-323 1.39e-41

D2 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320435 [Multi-domain]  Cd Length: 254  Bit Score: 146.72  E-value: 1.39e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  25 FFAMVILMAILGNLLVMVAVCRDRQLrKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSLDVLLT 104
Cdd:cd15309     6 LLTLLIFVIVFGNVLVCMAVSREKAL-QTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWRFSRIHCDIFVTLDVMMC 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 105 TASIFHLCCISLDRYYAIcCQPLVYRNKMTP-LRIALMLGGCWVIPMFISfLPIMQGWNNIGivdviekrkfnhnsnSTF 183
Cdd:cd15309    85 TASILNLCAISIDRYTAV-AMPMLYNTRYSSkRRVTVMISVVWVLSFAIS-CPLLFGLNNTD---------------QNE 147
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 184 CvFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTakehaqqiqmlqragatsesrpqtadqhsthrMRTETKAAKTLCV 263
Cdd:cd15309   148 C-IIANPAFVVYSSIVSFYVPFIVTLLVYVQIYIV--------------------------------LQKEKKATQMLAI 194
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 264 IMGCFCFCWAPFFVTNIVDPFIDYTVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15309   195 VLGVFIICWLPFFITHILNMHCDCNIPPALYSAFTWLGYVNSAVNPIIYTTFNIEFRKAF 254
7tmA_mAChR_DM1-like cd15301
muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G ...
20-323 1.58e-41

muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes muscarinic acetylcholine receptor DM1-like from invertebrates. Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320428 [Multi-domain]  Cd Length: 270  Bit Score: 147.28  E-value: 1.58e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIkTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSL 99
Cdd:cd15301     1 VLIVIVAAVLSLVTVGGNVMVMISFKIDKQLQTI-SNYFLFSLAVADFAIGVISMPLFTVYTALGYWPLGYEVCDTWLAI 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 100 DVLLTTASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVIPMFIsFLPIMQGWNNIgivdvieKRKFNHNS 179
Cdd:cd15301    80 DYLASNASVLNLLIISFDRYFSV-TRPLTYRARRTTKKAAVMIASAWIISLLL-WPPWIYSWPYI-------EGKRTVPA 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 180 NSTFCVFMVNKPY-AITCSVVAFYIPFLLMVLAYYRIYVTAKEHAQqiqmlqragatsesrpqtadqhsthrmRTETKAA 258
Cdd:cd15301   151 GTCYIQFLETNPYvTFGTALAAFYVPVTIMCILYWRIWRETKKRQK---------------------------KQESKAA 203
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1938531436 259 KTLCVIMGCFCFCWAPFFVTNIVDPF--IDYTVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15301   204 KTLSAILLAFIVTWTPYNVLVLIKAFfpCSDTIPTELWDFSYYLCYINSTINPLCYALCNAAFRRTY 270
7tmA_mAChR_M1 cd17790
muscarinic acetylcholine receptor subtype M1, member of the class A family of ...
31-323 2.96e-41

muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. M1 is the dominant mAChR subtype involved in learning and memory. It is linked to synaptic plasticity, neuronal excitability, and neuronal differentiation during early development. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341356 [Multi-domain]  Cd Length: 262  Bit Score: 146.27  E-value: 2.96e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  31 LMAILGNLLVMVAVCRDRQLRKIkTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSLDVLLTTASIFH 110
Cdd:cd17790    12 LVTVTGNLLVLISFKVNSELKTV-NNYFLLSLACADLIIGAFSMNLYTTYILMGHWALGTVACDLWLALDYVASNASVMN 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 111 LCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVIPmFISFLPIMQGWNNIGIVDVIEkrkfnhnSNSTFCVFMVNK 190
Cdd:cd17790    91 LLIISFDRYFSI-TRPLTYRAKRTPRRAAIMIGLAWLIS-FVLWAPAILFWQYLVGERTVL-------AGQCYIQFLSQP 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 191 PYAITCSVVAFYIPFLLMVLAYYRIYvtakehaqqiqmlqragatsesrpqtadqhstHRMRTETKAAKTLCVIMGCFCF 270
Cdd:cd17790   162 IITFGTAIAAFYLPVTIMIILYWRIY--------------------------------RETIKEKKAARTLSAILLAFIL 209
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1938531436 271 CWAPFFVTNIVDPFIDYTVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd17790   210 TWTPYNIMVLVSTFCKDCVPKTLWELGYWLCYVNSTVNPMCYALCNKSFRDTF 262
7tmA_D4_dopamine_R cd15308
D4 dopamine receptor of the D2-like family, member of the class A family of ...
23-323 5.26e-41

D4 dopamine receptor of the D2-like family, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320434 [Multi-domain]  Cd Length: 258  Bit Score: 145.36  E-value: 5.26e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  23 LTFFAMVILMAILGNLLVMVAVCRDRQLrKIKTNYFIVSLAFADLLVSVLVMP-FGAIELVQDIWFYGEMFCLVRTSLDV 101
Cdd:cd15308     4 LVGGVLLILAIIAGNVLVCLSVCTERAL-KTTTNYFIVSLAVADLLLALLVLPlYVYSEFQGGVWTLSPVLCDALMTMDV 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 102 LLTTASIFHLCCISLDRYYAICCqPLVYRNKMTPLRIALMLGGCWVIPMFISfLPIMQGWNNIgivdviekrkfnHNSNS 181
Cdd:cd15308    83 MLCTASIFNLCAISVDRFIAVSV-PLNYNRRQGSVRQLLLISATWILSFAVA-SPVIFGLNNV------------PNRDP 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 182 TFCVFMVNKpYAITCSVVAFYIPFLLMVLAYYRIYvtakehaqqiqmlqragatsesrpqtadqhstHRMRTETKAAKTL 261
Cdd:cd15308   149 AVCKLEDNN-YVVYSSVCSFFIPCPVMLVLYCAMF--------------------------------RGLGRERKAMRVL 195
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1938531436 262 CVIMGCFCFCWAPFFVTNIVDPFIDY-TVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15308   196 PVVVGAFLFCWTPFFVVHITRALCEScSIPPQLISIVTWLGYVNSALNPVIYTVFNAEFRNVF 258
7tmA_5-HT2_insect-like cd15307
serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane ...
28-329 1.68e-39

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320433 [Multi-domain]  Cd Length: 279  Bit Score: 142.01  E-value: 1.68e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  28 MVILMAILGNLLVMVAVCRDRQLRKIkTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSLDVLLTTAS 107
Cdd:cd15307     9 VLVLGTAAGNILVCLAIAWERRLQNV-TNYFLMSLAITDLMVAVLVMPLGILTLVKGHFPLSSEHCLTWICLDVLFCTAS 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 108 IFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVIPMFISfLPIMQGWNNigivdviekrkfNHNSNSTFCVFM 187
Cdd:cd15307    88 IMHLCTISVDRYLSL-RYPMRFGRNKTRRRVTLKIVFVWLLSIAMS-LPLSLMYSK------------DHASVLVNGTCQ 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 188 VNKP-YAITCSVVAFYIPFLLMVLAYyriyvtakehAQQIQMLQRagatsesrpqtadQHSTH--RMRTETKAAKTLCVI 264
Cdd:cd15307   154 IPDPvYKLVGSIVCFYIPLGVMLLTY----------CLTVRLLAR-------------QRSRHgrIIRLEQKATKVLGVV 210
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1938531436 265 MGCFCFCWAPFFVTNI---VDPFIDYTVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCC 329
Cdd:cd15307   211 FFTFVILWSPFFVLNLlptVCAECEERISHWVFDVVTWLGYASSMVNPIFYTIFNKVFRQAFKKVLLC 278
7tmA_NPFFR cd15207
neuropeptide FF receptors, member of the class A family of seven-transmembrane G ...
20-323 7.30e-38

neuropeptide FF receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320335 [Multi-domain]  Cd Length: 291  Bit Score: 137.75  E-value: 7.30e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIkTNYFIVSLAFADLLVSVLVMPFgaiELVQDI---WFYGEMFCLVR 96
Cdd:cd15207     1 VLFIVSYSLIFLLCVVGNVLVCLVVAKNPRMRTV-TNYFILNLAVSDLLVGVFCMPF---TLVDNIltgWPFGDVMCKLS 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  97 TSLDVLLTTASIFHLCCISLDRYYAIccqplVY--RNKMTPLRIALMLGGCWVIPMFISfLPIMqgwnnigIVDVIEKRK 174
Cdd:cd15207    77 PLVQGVSVAASVFTLVAIAVDRYRAV-----VHptEPKLTNRQAFVIIVAIWVLALAIM-IPQA-------LVLEVKEYQ 143
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 175 FNHNSNSTFCV-----FMVNKPYAITCSVVAFYIPFLLMVLAYYRIyvtakehAQQIQMLQRAGATSESRPQtadqhSTH 249
Cdd:cd15207   144 FFRGQTVHICVefwpsDEYRKAYTTSLFVLCYVAPLLIIAVLYVRI-------GYRLWFKPVPGGGSASREA-----QAA 211
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 250 RMRTETKAAKTLCVIMGCFCFCWAPFFVTNIVDPFIDYTVPEK------VWTAFLWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15207   212 VSKKKVRVIKMLIVVVVLFALSWLPLHTVTMLDDFGNLSPNQRevlyvyIYPIAHWLAYFNSCVNPIVYGYFNRNFRKGF 291
7tmA_5-HT2A cd15304
serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...
28-323 9.46e-38

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341345 [Multi-domain]  Cd Length: 267  Bit Score: 136.99  E-value: 9.46e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  28 MVILMAILGNLLVMVAVCRDRQLRKiKTNYFIVSLAFADLLVSVLVMPFGAIELVQDI-WFYGEMFCLVRTSLDVLLTTA 106
Cdd:cd15304     9 IVIILTIAGNILVIMAVSLEKKLQN-ATNYFLMSLAIADMLLGFLVMPVSMLTILYGYrWPLPSKLCAVWIYLDVLFSTA 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 107 SIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVIPMFISF-LPIMqgwnniGIVDviEKRKFNHNSnstfcV 185
Cdd:cd15304    88 SIMHLCAISLDRYIAI-RNPIHHSRFNSRTKAFLKIIAVWTISVGISMpIPVF------GLQD--DSKVFKEGS-----C 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 186 FMVNKPYAITCSVVAFYIPFLLMVLAYyriYVTAKEHAQQIQmlqragatsesrpqtadqhsthrmrTETKAAKTLCVIM 265
Cdd:cd15304   154 LLADENFVLIGSFVAFFIPLTIMVITY---FLTIKSLQQSIS-------------------------NEQKASKVLGIVF 205
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1938531436 266 GCFCFCWAPFFVTNIVDPFIDYTVPEKVWTA----FLWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15304   206 FLFVVMWCPFFITNVMAVICKESCNEVVIGGllnvFVWIGYLSSAVNPLVYTLFNKTYRSAF 267
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
20-323 1.25e-37

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 136.95  E-value: 1.25e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIkTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSL 99
Cdd:cd14969     1 YVLAVYLSLIGVLGVVLNGLVIIVFLKKKKLRTP-LNLFLLNLALADLLMSVVGYPLSFYSNLSGRWSFGDPGCVIYGFA 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 100 DVLLTTASIFHLCCISLDRYYAICCqPLVYRnKMTPLRIALMLGGCWVIPMFISFLPIMqGWNNIGiVDVIEKR-----K 174
Cdd:cd14969    80 VTFLGLVSISTLAALAFERYLVIVR-PLKAF-RLSKRRALILIAFIWLYGLFWALPPLF-GWSSYV-PEGGGTScsvdwY 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 175 FNHNSNSTFCVFMvnkpyaitcSVVAFYIPFLLMVLAYYRIYVTAKEHAQQIQMLQRAGATSESRpqtadqhsthrmRTE 254
Cdd:cd14969   156 SKDPNSLSYIVSL---------FVFCFFLPLAIIIFCYYKIYRTLRKMSKRAARRKNSAITKRTK------------KAE 214
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 255 TKAAKTLCVIMGCFCFCWAP---------FFVTNIVDPFIdYTVPE---KvwTAFLWlgyinsglNPFLYAFLNKSFRRA 322
Cdd:cd14969   215 KKVAKMVLVMIVAFLIAWTPyavvslyvsFGGESTIPPLL-ATIPAlfaK--SSTIY--------NPIIYVFMNKQFRRA 283

                  .
gi 1938531436 323 F 323
Cdd:cd14969   284 L 284
7tmA_NPYR-like cd15203
neuropeptide Y receptors and related proteins, member of the class A family of ...
20-323 1.71e-37

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.


Pssm-ID: 320331 [Multi-domain]  Cd Length: 293  Bit Score: 136.97  E-value: 1.71e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIkTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSL 99
Cdd:cd15203     1 IILILLYGLIIVLGVVGNLLVIYVVLRNKSMQTV-TNIFILNLAVSDLLLCLVSLPFTLIYTLTKNWPFGSILCKLVPSL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 100 DVLLTTASIFHLCCISLDRYYAICCqPLvyRNKMTPLRIALMLGGCWVIPMFISfLPIMQgwnnigIVDVIEKRKFNHNS 179
Cdd:cd15203    80 QGVSIFVSTLTLTAIAIDRYQLIVY-PT--RPRMSKRHALLIIALIWILSLLLS-LPLAI------FQELSDVPIEILPY 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 180 NSTFCV-----FMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAQQIQMLQRAGATSESRPqTADQHSTHRMrte 254
Cdd:cd15203   150 CGYFCTeswpsSSSRLIYTISVLVLQFVIPLLIISFCYFRISLKLRKRVKKKRGKRTLSSRRRRSE-LRRKRRTNRL--- 225
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1938531436 255 tkaaktLCVIMGCFCFCWAPFFVTNIVD-----PFIDYTVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15203   226 ------LIAMVVVFAVCWLPLNLFNLLRdfeplPQIDGRHFYLIFLICHLIAMSSACVNPLLYGWLNDNFRKEF 293
7tmA_Adenosine_R_A2A cd15068
adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G ...
20-323 5.41e-37

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2A receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320196 [Multi-domain]  Cd Length: 293  Bit Score: 135.84  E-value: 5.41e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIkTNYFIVSLAFADLLVSVLVMPFG-AIELVQDIWFYGemfCLVRTS 98
Cdd:cd15068     1 SVYITVELAIAVLAILGNVLVCWAVWLNSNLQNV-TNYFVVSLAAADIAVGVLAIPFAiTISTGFCAACHG---CLFIAC 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  99 LDVLLTTASIFHLCCISLDRYYAICCqPLVYRNKMTPLRIALMLGGCWVIPMFISFLPiMQGWNNIGIVDVIEKRKFNHN 178
Cdd:cd15068    77 FVLVLTQSSIFSLLAIAIDRYIAIRI-PLRYNGLVTGTRAKGIIAICWVLSFAIGLTP-MLGWNNCGQPKEGKNHSQGCG 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 179 SNSTFCVF--MVNKPYAITCSVVA-FYIPFLLMVLAYYRIYVTAKEHAQQIQMLQRAGATSESRPQtadqhsthrmrTET 255
Cdd:cd15068   155 EGQVACLFedVVPMNYMVYFNFFAcVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQ-----------KEV 223
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 256 KAAKTLCVIMGCFCFCWAPFFVTNIVDPFIDYTVPEKVWTAFL--WLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15068   224 HAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLaiVLSHTNSVVNPFIYAYRIREFRQTF 293
7tmA_mAChR_M5 cd15300
muscarinic acetylcholine receptor subtype M5, member of the class A family of ...
20-323 1.58e-35

muscarinic acetylcholine receptor subtype M5, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. M5 mAChR is primarily found in the central nervous system and mediates acetylcholine-induced dilation of cerebral blood vessels. Activation of M5 receptor triggers a variety of cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides, and modulation of potassium channels. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320427 [Multi-domain]  Cd Length: 262  Bit Score: 130.92  E-value: 1.58e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIkTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSL 99
Cdd:cd15300     1 ITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTV-NNYYLLSLACADLIIGIFSMNLYTSYILMGYWALGSLACDLWLAL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 100 DVLLTTASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVIPmFISFLPIMQGWNNIGIVDVIEKRKFNHNs 179
Cdd:cd15300    80 DYVASNASVMNLLVISFDRYFSI-TRPLTYRAKRTPKRAGIMIGLAWLIS-FILWAPPILCWQYFVGKRTVPERECQIQ- 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 180 nstfcvFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYvtaKEHAQqiqmlqragatsesrpqtadqhsthrmrtETKAAK 259
Cdd:cd15300   157 ------FLSEPTITFGTAIAAFYIPVSVMTILYCRIY---KETIK-----------------------------ERKAAQ 198
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1938531436 260 TLCVIMGCFCFCWAPFFVTNIVDPFIDYTVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15300   199 TLSAILLAFIITWTPYNIMVLVSTFCSDCIPLTLWHLGYWLCYVNSTVNPMCYALCNKTFRKTF 262
7tmA_mAChR_GAR-2-like cd15302
muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of ...
20-323 2.58e-35

muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320429 [Multi-domain]  Cd Length: 266  Bit Score: 130.63  E-value: 2.58e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIkTNYFIVSLAFADLLVSVLVMPFGAIELVQ-DIWFYGEMFCLVRTS 98
Cdd:cd15302     1 ILLALITAILSIITVIGNILVLLSFYVDRNIRQP-SNYFIASLAVSDLLIGLESMPFYTVYVLNgDYWPLGWVLCDLWLS 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  99 LDVLLTTASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMqGWNNigivdviekrkFNHN 178
Cdd:cd15302    80 VDYTVCLVSIYTVLLITIDRYCSV-KIPAKYRNWRTPRKVLLIIAITWIIPALLFFISIF-GWQY-----------FTGQ 146
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 179 SNS-----TFCVFMVNkPYAITCSVVAFY-IPFLLMVLAYYRIYVTAKehaqqiqmlqragatsesrpqtadqhsthRMR 252
Cdd:cd15302   147 GRSlpegeCYVQFMTD-PYFNMGMYIGYYwTTLIVMLILYAGIYRAAN-----------------------------RAR 196
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1938531436 253 tetKAAKTLCVIMGCFCFCWAPFFVTNIVDPFIDYT--VPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15302   197 ---KALRTITFILGAFVICWTPYHILATIYGFCEAPpcVNETLYTISYYLCYMNSPINPFCYALANQQFKKTF 266
7tmA_TACR cd15390
neurokinin receptors (or tachykinin receptors), member of the class A family of ...
26-323 7.21e-35

neurokinin receptors (or tachykinin receptors), member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320512 [Multi-domain]  Cd Length: 289  Bit Score: 129.72  E-value: 7.21e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  26 FAMVILMAILGNLLVMVAVCRDRQLRKIkTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSLDVLLTT 105
Cdd:cd15390     7 FVVMVLVAIGGNLIVIWIVLAHKRMRTV-TNYFLVNLAVADLLISAFNTVFNFTYLLYNDWPFGLFYCKFSNFVAITTVA 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 106 ASIFHLCCISLDRYYAIcCQPLvyRNKMTPLRIALMLGGCWVIPMFISFlPIMqgwnnigIVDVIEKRKFNHNSNSTFCV 185
Cdd:cd15390    86 ASVFTLMAISIDRYIAI-VHPL--RPRLSRRTTKIAIAVIWLASFLLAL-PQL-------LYSTTETYYYYTGSERTVCF 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 186 F--------MVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTakehaqqiqmLQRAGATSESRPQTADQhsthrMRTETKA 257
Cdd:cd15390   155 IawpdgpnsLQDFVYNIVLFVVTYFLPLIIMAVAYTRVGVE----------LWGSKTIGENTPRQLES-----VRAKRKV 219
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 258 AKTLCVIMGCFCFCWAP----FFVTNIVDPFIDYTVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15390   220 VKMMIVVVVIFAICWLPyhlyFILTYLYPDINSWKYIQQIYLAIYWLAMSNSMYNPIIYCWMNKRFRYGF 289
7tmA_mAChR_M2 cd15297
muscarinic acetylcholine receptor subtype M2, member of the class A family of ...
31-323 2.00e-34

muscarinic acetylcholine receptor subtype M2, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of M2 receptor causes a decrease in cAMP production, generally leading to inhibitory-type effects. This causes an outward current of potassium in the heart, resulting in a decreased heart rate. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320424 [Multi-domain]  Cd Length: 262  Bit Score: 128.16  E-value: 2.00e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  31 LMAILGNLLVMVAVCRDRQLRKIkTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSLDVLLTTASIFH 110
Cdd:cd15297    12 LVTIIGNILVMVSIKVNRHLQTV-NNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMN 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 111 LCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVIPmFISFLPIMQGWNNIGIVDVIEKRKfnhnsnsTFCVFMVNK 190
Cdd:cd15297    91 LLIISFDRYFCV-TKPLTYPVKRTTKMAGMMIAAAWVLS-FILWAPAILFWQFIVGGRTVPEGE-------CYIQFFSNA 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 191 PYAITCSVVAFYIPFLLMVLAYYRIyvtakehaqqiqmlqragATSESRpqtadqhsthrmrtETKAAKTLCVIMGCFCF 270
Cdd:cd15297   162 AVTFGTAIAAFYLPVIIMTVLYWQI------------------SRASSR--------------EKKVTRTILAILLAFII 209
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1938531436 271 CWAPFFVTNIVDPFIDYTVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15297   210 TWTPYNVMVLINTFCASCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTF 262
7tmA_EDG-like cd14972
endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...
31-323 1.80e-33

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 341317 [Multi-domain]  Cd Length: 275  Bit Score: 125.87  E-value: 1.80e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  31 LMAILGNLLVMVAVCRDRQLRKIkTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSLDVLLTtASIFH 110
Cdd:cd14972    10 VFIVVENSLVLAAIIKNRRLHKP-MYILIANLAAADLLAGIAFVFTFLSVLLVSLTPSPATWLLRKGSLVLSLL-ASAYS 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 111 LCCISLDRYYAICcQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMqGWNNIGIVDVIEKRKFNHNSNStfcvfmvnk 190
Cdd:cd14972    88 LLAIAVDRYISIV-HGLTYVNNVTNKRVKVLIALVWVWSVLLALLPVL-GWNCVLCDQESCSPLGPGLPKS--------- 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 191 pYAITCsVVAFYIPFLLMVLAYYRIYVTAKEHAQQIQMLQRAGATSESrpqtadqhsthrmRTETKAAKTLCVIMGCFCF 270
Cdd:cd14972   157 -YLVLI-LVFFFIALVIIVFLYVRIFWCLWRHANAIAARQEAAVPAQP-------------STSRKLAKTVVIVLGVFLV 221
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1938531436 271 CWAPFFVTNIVDPFIDYTV-PEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd14972   222 CWLPLLILLVLDVLCPSVCdIQAVFYYFLVLALLNSAINPIIYAFRLKEMRRAV 275
7tmA_Opioid_R-like cd14970
opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...
20-323 2.49e-33

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.


Pssm-ID: 320101 [Multi-domain]  Cd Length: 282  Bit Score: 125.48  E-value: 2.49e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIkTNYFIVSLAFADLLVsVLVMPFGAIELVQDIWFYGEMFCLVRTSL 99
Cdd:cd14970     1 IVIPAVYSVVCVVGLTGNSLVIYVILRYSKMKTV-TNIYILNLAVADELF-LLGLPFLATSYLLGYWPFGEVMCKIVLSV 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 100 DVLLTTASIFHLCCISLDRYYAICCqPLVYRNKMTPLRIALMLGGCWVIPmFISFLPIMqgwnnigivdvIEKRKFNHNS 179
Cdd:cd14970    79 DAYNMFTSIFCLTVMSVDRYLAVVH-PVKSLRFRTPRKAKLVSLCVWALS-LVLGLPVI-----------IFARTLQEEG 145
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 180 NSTFCVFMVNKPY-------AITCSVVAFYIPFLLMVLAYYRIyvtakehaqqIQMLQRAGATSESrpqtadqHSTHRMR 252
Cdd:cd14970   146 GTISCNLQWPDPPdywgrvfTIYTFVLGFAVPLLVITVCYSLI----------IRRLRSSRNLSTS-------GAREKRR 208
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1938531436 253 TETKAAKTLCVIMGCFCFCWAPFFVTNIVDPFIDY---TVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd14970   209 ARRKVTRLVLVVVAVFVVCWLPFHVFQIVRLLIDPpetLTVVGVFLFCIALSYANSCLNPILYAFLDENFRKSF 282
7tmA_Adenosine_R_A2B cd15069
adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...
24-323 1.23e-32

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320197 [Multi-domain]  Cd Length: 294  Bit Score: 124.27  E-value: 1.23e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  24 TFFAMVILMAIL---GNLLVMVAVCRDRQLrKIKTNYFIVSLAFADLLVSVLVMPFG-AIELVQDIWFYGemfCLVRTSL 99
Cdd:cd15069     2 TYVALELIIAALsvaGNVLVCAAVGTNSTL-QTPTNYFLVSLAAADVAVGLFAIPFAiTISLGFCTDFHS---CLFLACF 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 100 DVLLTTASIFHLCCISLDRYYAICCqPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMqGWNNIGIVDVIEKRKFNHNS 179
Cdd:cd15069    78 VLVLTQSSIFSLLAVAVDRYLAIKV-PLRYKSLVTGKRARGVIAVLWVLAFGIGLTPFL-GWNKAMSATNNSTNPADHGT 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 180 NSTFCVFMVNKPYAITCSVVAFY-------IPFLLMVLAYYRIYVTAKEHAQQIQMLQragatsesrpqtadqHSTHRMR 252
Cdd:cd15069   156 NHSCCLISCLFENVVPMSYMVYFnffgcvlPPLLIMLVIYIKIFLVACRQLQRTELMD---------------HSRTTLQ 220
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1938531436 253 TETKAAKTLCVIMGCFCFCWAPFFVTNIV---DPFIDYTVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15069   221 REIHAAKSLAIIVGIFALCWLPVHILNCItlfQPEFSKSKPKWAMNVAILLSHANSVVNPIVYAYRNRDFRYTF 294
7tmA_leucokinin-like cd15393
leucokinin-like peptide receptor from tick and related proteins, member of the class A family ...
21-323 1.28e-32

leucokinin-like peptide receptor from tick and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a leucokinin-like peptide receptor from the Southern cattle tick, Boophilus microplus, a pest of cattle world-wide. Leucokinins are invertebrate neuropeptides that exhibit myotropic and diuretic activity. This receptor is the first neuropeptide receptor known from the Acari and the second known in the subfamily of leucokinin-like peptide G-protein-coupled receptors. The other known leucokinin-like peptide receptor is a lymnokinin receptor from the mollusc Lymnaea stagnalis.


Pssm-ID: 320515 [Multi-domain]  Cd Length: 288  Bit Score: 124.06  E-value: 1.28e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  21 VLLTFFAMVI-LMAILGNLLVMVAVCRDRQLRKIkTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSL 99
Cdd:cd15393     1 VLLSILYGIIsLVAVVGNFLVIWVVAKNRRMRTV-TNIFIANLAVADIIIGLFSIPFQFQAALLQRWVLPRFMCPFCPFV 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 100 DVLLTTASIFHLCCISLDRYYAICcQPLvyRNKMTPLRIALMLGGCWVIPMFISfLPIMQGWNnigivdVIEKRKFNHNS 179
Cdd:cd15393    80 QVLSVNVSVFTLTVIAVDRYRAVI-HPL--KARCSKKSAKIIILIIWILALLVA-LPVALALR------VEELTDKTNNG 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 180 NSTFC--VFMVN---KPYAITCSVVAFYIPFLLMVLAYYRIyvtakehAQQIQMLQRAGATSESRPQtadqhstHRMRTE 254
Cdd:cd15393   150 VKPFClpVGPSDdwwKIYNLYLVCVQYFVPLVIICYAYTRI-------AVKIWGTKAPGNAQDVRDD-------EILKNK 215
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1938531436 255 TKAAKTLCVIMGCFCFCWAPFFVTNI---VDPFID-YTVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15393   216 KKVIKMLIIVVALFALCWLPLQTYNLlneIKPEINkYKYINIIWFCSHWLAMSNSCYNPFIYGLYNEKFKREF 288
7tmA_Histamine_H4R cd15295
histamine receptor subtype H4R, member of the class A family of seven-transmembrane G ...
20-328 5.78e-32

histamine receptor subtype H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtype H4R, a member of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320422 [Multi-domain]  Cd Length: 267  Bit Score: 121.47  E-value: 5.78e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKiKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSL 99
Cdd:cd15295     1 VVLLFLMSLLALVIVLGNALVIIAFVVDKNLRH-RSNYFFLNLAISDFFVGAISIPLYIPYTLTNRWDFGRGLCVFWLVI 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 100 DVLLTTASIFHLCCISLDRYYAIcCQPLVYRNKMTP-LRIALMLGGCWVIPmFISFLPIMQGWNNIGIVDviekrkfnhn 178
Cdd:cd15295    80 DYLLCTASVYNIVLISYDRYQSV-SNAVSYRNQQTAtLRIVTQMVAVWVLA-FLVHGPAILVSDSWKTED---------- 147
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 179 snsTFCV--FMVNKPYAITCSVVAFYIPFLLMVLAYYRIYvtakehaqqiqmlqragatsesrpqtadqHSTHRMRTETK 256
Cdd:cd15295   148 ---GECEpeFFSNWYILAITSVLEFLVPVILVAYFNTQIY-----------------------------WSLWKRLRDRK 195
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1938531436 257 AAKTLCVIMGCFCFCWAPFFVTNIVDPFIDyTVPEKVWTAF-LWLGYINSGLNPFLYAFLNKSFRRAFLIILC 328
Cdd:cd15295   196 LAKSLAIILGTFAICWAPYSLFTIIRAACE-KHRGSPWYNFaFWLQWFNSFINPFLYPLCHKRFRKAFLKIFC 267
7tmA_TACR-like cd15202
tachykinin receptors and related receptors, member of the class A family of ...
20-323 7.14e-32

tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320330 [Multi-domain]  Cd Length: 288  Bit Score: 121.84  E-value: 7.14e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIkTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSL 99
Cdd:cd15202     1 VLLIVAYSFIIVFSLFGNVLVCWIIFKNQRMRTV-TNYFIVNLAVADIMITLFNTPFTFVRAVNNTWIFGLFMCHFSNFA 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 100 DVLLTTASIFHLCCISLDRYYAIcCQPLVYRnkMTPLRIALMLGGCWVIPMFISFlpimqgwnNIGIVDVIEKRKFNHNS 179
Cdd:cd15202    80 QYCSVHVSAYTLTAIAVDRYQAI-MHPLKPR--ISKTKAKFIIAVIWTLALAFAL--------PHAICSKLETFKYSEDI 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 180 NSTFCVFMVNKP-------YAITCSVVAFYIPFLLMVLAYYRIYVTAKEhaqqiqmlqragatSESrPQTADQHSTHRM- 251
Cdd:cd15202   149 VRSLCLEDWPERadlfwkyYDLALFILQYFLPLLVISFAYARVGIKLWA--------------SNM-PGDATTERYFALr 213
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1938531436 252 RTETKAAKTLCVIMGCFCFCWAPFFVTNI---VDPFIDYTVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15202   214 RKKKKVIKMLMVVVVLFALCWLPFNIYVLllsSKPDYLIKTINAVYFAFHWLAMSSTCYNPFIYCWLNERFRIEF 288
7tmA_mAChR_M4 cd15298
muscarinic acetylcholine receptor subtype M4, member of the class A family of ...
20-323 2.05e-31

muscarinic acetylcholine receptor subtype M4, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to G(i/o) types of G proteins. The M4 receptor is mainly found in the CNS and function as an inhibitory autoreceptor regulating acetycholine release. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341344 [Multi-domain]  Cd Length: 262  Bit Score: 120.12  E-value: 2.05e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIkTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSL 99
Cdd:cd15298     1 VFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTV-NNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLAL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 100 DVLLTTASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVIPmFISFLPIMQGWNNIgivdvIEKRKFnhNS 179
Cdd:cd15298    80 DYVVSNASVMNLLIISFDRYFCV-TKPLTYPARRTTKMAGLMIAAAWVLS-FVLWAPAILFWQFV-----VGKRTV--PD 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 180 NSTFCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEhaqqiqmlqragatsesrpqtadqhsthrmrtETKAAK 259
Cdd:cd15298   151 NQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASAR--------------------------------ERKVTR 198
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1938531436 260 TLCVIMGCFCFCWAPFFVTNIVDPFIDYTVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15298   199 TIFAILLAFILTWTPYNVMVLVNTFCQSCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTF 262
7tmA_QRFPR cd15205
pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane ...
20-323 4.34e-31

pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that belongs to a family of neuropeptides containing an Arg-Phe-NH2 (RFamide) motif at its C-terminus. 26Rfa/QRFP exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103.


Pssm-ID: 320333 [Multi-domain]  Cd Length: 298  Bit Score: 119.89  E-value: 4.34e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIkTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSL 99
Cdd:cd15205     1 TAFVITYVLIFVLALFGNSLVIYVVTRKRAMRTA-TNIFICSLALSDLLITFFCIPFTLLQNISSNWLGGAFMCKMVPFV 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 100 DVLLTTASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVIPMFIS--FLPIMQgwnnigivdVIEKRKFNH 177
Cdd:cd15205    80 QSTAVVTSILTMTCIAVERHQGI-VHPLKMKWQYTNRRAFTMLGLVWIVSVIVGspMLFVQQ---------LEVKYDFLY 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 178 NSNSTFCV-----FMVNKPYAITCSVVAFYIPFLLMVLAYYRIyvtakehAQQIQMLQRAGATSESRPQTADQHSThRMR 252
Cdd:cd15205   150 EKRHVCCLerwysPTQQKIYTTFILVILFLLPLTTMLFLYSRI-------GYELWIKKRVGDASVLQTIHGIEMSK-ISR 221
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 253 TETKAAKTLCVIMGCFCFCWAPFFVTNIVdpfIDYTVPEK---------VWTAFLWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15205   222 KKKRAVKMMVTVVLLFAVCWAPFHVVHMM---IEYSNLENkydgvtiklIFAIVQLIGFSNSFNNPIVYAFMNENFKKNF 298
7tmA_PR4-like cd15392
neuropeptide Y receptor-like found in insect and related proteins, member of the class A ...
20-323 6.60e-31

neuropeptide Y receptor-like found in insect and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a novel G protein-coupled receptor (also known as PR4 receptor) from Drosophila melanogaster, which can be activated by the members of the neuropeptide Y (NPY) family, including NPY, peptide YY (PYY) and pancreatic polypeptide (PP), when expressed in Xenopus oocytes. These homologous peptides of 36-amino acids in length contain a hairpin-like structural motif, which referred to as the pancreatic polypeptide fold, and function as gastrointestinal hormones and neurotransmitters. The PR4 receptor also shares strong sequence homology to the mammalian tachykinin receptors (NK1R, NK2R, and NK3R), whose endogenous ligands are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), respectively. The tachykinins function as excitatory transmitters on neurons and cells in the gastrointestinal tract.


Pssm-ID: 320514 [Multi-domain]  Cd Length: 287  Bit Score: 119.39  E-value: 6.60e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIkTNYFIVSLAFADLLVSVLVMPFGAIE-LVQDIWFYGEMFCLVRTS 98
Cdd:cd15392     1 VIIILMYSTIFVLAVGGNGLVCYIVVSYPRMRTV-TNYFIVNLALSDILMAVFCVPFSFIAlLILQYWPFGEFMCPVVNY 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  99 LDVLLTTASIFHLCCISLDRYYAIcCQPLvyRNKMTPLRIALMLGGCWVIPMFISfLPIMqgwnnigIVDVIEKRKFNHN 178
Cdd:cd15392    80 LQAVSVFVSAFTLVAISIDRYVAI-MWPL--RPRMTKRQALLLIAVIWIFALATA-LPIA-------ITSRLFEDSNASC 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 179 SnSTFCV-----FMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTakehaqqiqmlqragATSESRPQTADQHSTHRM-R 252
Cdd:cd15392   149 G-QYICTeswpsDTNRYIYSLVLMILQYFVPLAVLVFTYTRIGIV---------------VWAKRTPGEAENNRDQRMaE 212
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1938531436 253 TETKAAKTLCVIMGCFCFCWAPFFVTNIV---DPFIDYTVPEK-VWTAFLWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15392   213 SKRKLVKMMITVVAIFALCWLPLNILNLVgdhDESIYSWPYIPyLWLAAHWLAMSHCCYNPFIYCWMNAKFRNGF 287
7tmA_TACR_family cd14992
tachykinin receptor and closely related proteins, member of the class A family of ...
20-323 9.30e-31

tachykinin receptor and closely related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family as well as closely related receptors. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320123 [Multi-domain]  Cd Length: 291  Bit Score: 119.07  E-value: 9.30e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIkTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSL 99
Cdd:cd14992     1 IILGVALVVIILVSVVGNFIVIAALARHKNLRGA-TNYFIASLAISDLLMALFCTPFNFTYVVSLSWEYGHFLCKIVNYL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 100 DVLLTTASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVIPMFISflpIMQGW----NNIGIVDVIEKRKF 175
Cdd:cd14992    80 RTVSVYASSLTLTAIAFDRYFAI-IHPLKPRHRQSYTTTVIIIITIWVVSLLLA---IPQLYyattEVLFSVKNQEKIFC 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 176 NHNSNSTFCVFMvnKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKehaqqiqmlqraGATSESRPQTADQHstHRMRTET 255
Cdd:cd14992   156 CQIPPVDNKTYE--KVYFLLIFVVIFVLPLIVMTLAYARISRELW------------FRKVPGFSIKEVER--KRLKCKR 219
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1938531436 256 KAAKTLCVIMGCFCFCWAPFFVTNIVDPFIDYTVPEK----VWTAFLWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd14992   220 RVIKMLVCVVVLFVICWLPFHLFFLLRDFFPLIMKEKhtlqVYYFLHWIAMSNSMYNPIIYVTLNNNFRKNF 291
7tmA_GPR84-like cd15210
G protein-coupled receptor 84 and similar proteins, member of the class A family of ...
28-323 1.97e-30

G protein-coupled receptor 84 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR84, also known as the inflammation-related G-Protein coupled receptor EX33, is a receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Among these medium-chain FFAs, capric acid (C10:0), undecanoic acid (C11:0), and lauric acid (C12:0) are the most potent endogenous agonists of GPR84, whereas short-chain and long-chain saturated and unsaturated FFAs do not activate this receptor. GPR84 contains a [G/N]RY-motif instead of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors and important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. In the case of GPR84, activation of the receptor couples to a pertussis toxin sensitive G(i/o)-protein pathway. GPR84 knockout mice showed increased Th2 cytokine production including IL-4, IL-5, and IL-13 compared to wild-type mice. It has been also shown that activation of GPR84 augments lipopolysaccharide-stimulated IL-8 production in polymorphonuclear leukocytes and TNF-alpha production in macrophages, suggesting that GPR84 may function as a proinflammatory receptor.


Pssm-ID: 320338 [Multi-domain]  Cd Length: 254  Bit Score: 116.98  E-value: 1.97e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  28 MVILMAILGNLLVMVAVCRDRQLRKIkTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSLDVLLTTAS 107
Cdd:cd15210     9 VFMVVGVPGNLLTVLALLRSKKLRTR-TNAFIINLSISDLLFCAFNLPLAASTFLHQAWIHGETLCRVFPLLRYGLVAVS 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 108 IFHLCCISLDRYYAICCQPLvYRNKMTPLRIALMLGGCWVIPMFISFLPIMQGWNNIGIVDVIEKRKFNHNSNStfcvfm 187
Cdd:cd15210    88 LLTLVLITLNRYILIAHPSL-YPRIYTRRGLALMIAGTWIFSFGSFLPLWLGIWGRFGLDPKVCSCSILRDKKG------ 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 188 vnKPYAITCSVVAFYIPFLLMVLAYYRiyvtakehaqqiqmlqragatsesrpqtadqhsthrmRTETKAAKTLCVIMGC 267
Cdd:cd15210   161 --RSPKTFLFVFGFVLPCLVIIICYAR-------------------------------------REDRRLTRMMLVIFLC 201
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1938531436 268 FCFCWAPFFVTNIVDPFIDYTVPEkVWTAFlwLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15210   202 FLVCYLPITLVNVFDDEVAPPVLH-IIAYV--LIWLSSCINPIIYVAMNRQYRQAY 254
7tmA_GPR135 cd15212
G protein-coupled receptor 135, member of the class A family of seven-transmembrane G ...
29-316 3.47e-30

G protein-coupled receptor 135, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR135, also known as the somatostatin- and angiotensin-like peptide receptor (SALPR), is found in various tissues including eye, brain, cervix, stomach, and testis. Pharmacological studies have shown that relaxin-3 (R3) is a high-affinity endogenous ligand for GPR135. R3 has recently been identified as a new member of the insulin/relaxin family of peptide hormones and is exclusively expressed in the brain neurons. In addition to GPR135, R3 also acts as an agonist for GPR142, a pseudogene in the rat, and can activate LGR7 (leucine repeat-containing G-protein receptor-7), which is the main receptor for relaxin-1 (R1) and relaxin-2 (R2). While R1 and R2 are hormones primarily associated with reproduction and pregnancy, R3 is involved in neuroendocrine and sensory processing. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320340 [Multi-domain]  Cd Length: 285  Bit Score: 117.18  E-value: 3.47e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  29 VILMAILGNLLVMVAVCRDRQLRKIkTNYFIVSLAFADLLVSVLVMPFGAIELVQ-DIWFYGEMFCLVRTSLDVLLTTAS 107
Cdd:cd15212    10 IFLLSSLGNCAVIGVIVKHRQLRTV-TNAFILSLSLSDLLTALLCLPFAFLTLFSrPGWLFGDRLCLANGFFNACFGIVS 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 108 IFHLCCISLDRYYAICCQPlvyRNKMTPLRIALMLGGCWVIPMFISFlpimqGWNNIGIVDVIEKRKFNHNSNSTFCV-- 185
Cdd:cd15212    89 TLTMTLISFDRYYAIVRQP---QGKIGRRRALQLLAAAWLTALGFSL-----PWYLLASAPEYYEKLGFYHCLYVLHSgp 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 186 FMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAQQIqmlqragatsesRPQTADQHSThRMRTETKAAKTLCVIM 265
Cdd:cd15212   161 SRLGAAYSSVLIVLCYLLPFALMCFCHYNICKTVRLSESRV------------RPVTTYAHLL-RFYSEMRTATTVLIMI 227
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1938531436 266 GCFCFCWAPFFVTNIVDPFIDYTVPEKVWTAFLWLGYINSGLNPFLYAFLN 316
Cdd:cd15212   228 VFIICCWGPYCLLGLVAAAGGYQFPPLMDTVAIWMAWANGAINPLIYAIRN 278
7tmA_GPRnna14-like cd15001
GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...
23-323 1.30e-29

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320132 [Multi-domain]  Cd Length: 266  Bit Score: 115.07  E-value: 1.30e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  23 LTFFAMVILMAILGNLLVMVAVCRDRQLRKIkTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSLDVL 102
Cdd:cd15001     3 IIVYVITFVLGLIGNSLVIFVVARFRRMRSV-TNVFLASLATADLLLLVFCVPLKTAEYFSPTWSLGAFLCKAVAYLQLL 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 103 LTTASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVIPMFISFlPIMQGwnNIGIVDVIEKRKFNHNSNST 182
Cdd:cd15001    82 SFICSVLTLTAISIERYYVI-LHPMKAKSFCTIGRARKVALLIWILSAILAS-PVLFG--QGLVRYESENGVTVYHCQKA 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 183 FCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRiyvtaKEHAQQIQMlqragatsesrpqtadqhsthrmrtetkaaktLC 262
Cdd:cd15001   158 WPSTLYSRLYVVYLAIVIFFIPLIVMTFAYAR-----DTRKQVIKM--------------------------------LI 200
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1938531436 263 VIMGCFCFCWAPFFVTNI-----VDPFIDYTVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15001   201 SVVVLFAVCWGPLLIDNLlvsfdVISTLHTQALKYMRIAFHLLSYANSCINPIIYAFMSKNFRSSF 266
7tmA_Adenosine_R_A3 cd15070
adenosine receptor subtype A3, member of the class A family of seven-transmembrane G ...
20-323 2.65e-29

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G protein-coupled receptors; The A3 receptor, a member of the adenosine receptor family of G protein-coupled receptors, is coupled to G proteins of the inhibitory G(i) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels. The A3 receptor has a sustained protective function in the heart during cardiac ischemia and contributes to inhibition of neutrophil degranulation in neutrophil-mediated tissue injury. Moreover, activation of A3 receptor by adenosine protects astrocytes from cell death induced by hypoxia.


Pssm-ID: 320198 [Multi-domain]  Cd Length: 280  Bit Score: 114.88  E-value: 2.65e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKiKTNYFIVSLAFADLLVSVLVMPFG-AIELVQDIWFYgemFCLVRTS 98
Cdd:cd15070     1 VTYISIEILIGLCAVVGNVLVIWVVKLNPSLRT-TTFYFIVSLALADIAVGVLVIPLAiVVSLGVTIHFY---SCLFMSC 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  99 LDVLLTTASIFHLCCISLDRYYAICCqPLVYRNKMTPLRIALMLGGCWVIPMFISFLPiMQGWNnigivdviEKRKFNHN 178
Cdd:cd15070    77 LLVVFTHASIMSLLAIAVDRYLRVKL-TVRYRIVTTQRRIWLALGLCWLVSFLVGLTP-MFGWN--------RKPSLESV 146
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 179 SNSTF-CVF--MVNKPYAITCSVVAF-YIPFLLMVLAYYRIYVTAKEhaqqiQMLQRAGATSESRPqtadqhsthRMRTE 254
Cdd:cd15070   147 NTTPLqCQFtsVMRMDYMVYFSFFTWiLIPLVIMCALYVDIFYIIRN-----KLSQNATGFRETGA---------FYGRE 212
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1938531436 255 TKAAKTLCVIMGCFCFCWAPFFVTNIVdPFIDYTVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15070   213 FKTAKSLALVLFLFAVCWLPLSIINCV-VYFNPKVPKIALYLGILLSHANSMMNPIVYACKIKKFKETY 280
7tmA_Melanopsin-like cd15083
vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...
20-322 1.46e-27

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320211 [Multi-domain]  Cd Length: 291  Bit Score: 110.12  E-value: 1.46e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIKtNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSL 99
Cdd:cd15083     1 YVLGIFILIIGLIGVVGNGLVIYAFCRFKSLRTPA-NYLIINLAISDFLMCILNCPLMVISSFSGRWIFGKTGCDMYGFS 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 100 DVLLTTASIFHLCCISLDRYYAICcQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMqGWNNIGIVDVIEKRKFNHNS 179
Cdd:cd15083    80 GGLFGIMSINTLAAIAVDRYLVIT-RPMKASVRISHRRALIVIAVVWLYSLLWVLPPLF-GWSRYVLEGLLTSCSFDYLS 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 180 NSTFcvfmvNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAQQIQMLQRAGATSESRPQTAdqhsthRMRTETKAAK 259
Cdd:cd15083   158 RDDA-----NRSYVICLLIFGFVLPLLIIIYCYSFIFRAVRRHEKAMKEMAKRFSKSELSSPKA------RRQAEVKTAK 226
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1938531436 260 TLCVIMGCFCFCWAPFFVTNIVDPFIDYTVPEKVWTAflWLGYI---NSGLNPFLYAFLNKSFRRA 322
Cdd:cd15083   227 IALLLVLLFCLAWTPYAVVALIGQFGYLEVLTPLATA--IPAAFaktSAIYNPVIYAFSHPKFRRA 290
7tmA_AstA_R_insect cd15096
allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G ...
20-323 4.67e-27

allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled AstA receptor binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320224 [Multi-domain]  Cd Length: 284  Bit Score: 108.54  E-value: 4.67e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIkTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSL 99
Cdd:cd15096     1 IVVPVIFGLIFIVGLIGNSLVILVVLSNQQMRST-TNILILNLAVADLLFVVFCVPFTATDYVLPTWPFGDVWCKIVQYL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 100 DVLLTTASIFHLCCISLDRYYAIccqplVYRNKMTPLR----IALMLGGCWVIpMFISFLPIMqgwnnigiVDVIEKRKF 175
Cdd:cd15096    80 VYVTAYASVYTLVLMSLDRYLAV-----VHPITSMSIRternTLIAIVGIWIV-ILVANIPVL--------FLHGVVSYG 145
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 176 NHNSNSTFCVFMVNKPYA-----ITCSVVAFYIPFLLMVLAYYRIyvtakehaqqIQMLQRaGATSESRPQTADQHSTHR 250
Cdd:cd15096   146 FSSEAYSYCTFLTEVGTAaqtffTSFFLFSYLIPLTLICVLYMLM----------LRRLRR-QKSPGGRRSAESQRGKRR 214
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1938531436 251 mrtetkAAKTLCVIMGCFCFCWAPFFVTNIVDPFIDYtvPEKVWT-----AFLWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15096   215 ------VTRLVVVVVVVFAICWLPIHIILLLKYYGVL--PETVLYvviqiLSNCLAYGNSCVNPILYAFLSQNFRKAF 284
7tmA_Histamine_H3R cd15296
histamine receptor subtypes H3R and H3R-like, member of the class A family of ...
20-323 6.08e-27

histamine receptor subtypes H3R and H3R-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H3R-like, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320423 [Multi-domain]  Cd Length: 271  Bit Score: 107.95  E-value: 6.08e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKiKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSL 99
Cdd:cd15296     1 VILAVLMALLVVATVLGNALVILAFVVDSSLRT-QGNFFFLNLAISDFLVGGFCIPLYIPYVLTGRWKFGRGLCKLWLVV 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 100 DVLLTTASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMQGWNNIGIVDVIEKrkfnhns 179
Cdd:cd15296    80 DYLLCTASVFNIVLISYDRFLSV-TRAVSYRAQKGMTRQAVLKMVLVWVLAFLLYGPAIISWEYIAGGSIIPE------- 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 180 NSTFCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAkehaqqiqmlqragatsesrpqtadQHSTHRMRTETKAAK 259
Cdd:cd15296   152 GECYAEFFYNWYFLMTASTLEFFTPFISVTYFNLSIYLNI-------------------------QKRRFRLSRDKKVAK 206
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1938531436 260 TLCVIMGCFCFCWAPFFVTNIVDPFID-YTVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15296   207 SLAIIVCVFGLCWAPYTLLMIIRAACHgHCVPDYWYETSFWLLWVNSAINPVLYPLCHMSFRRAF 271
7tmA_MCHR-like cd15088
melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G ...
20-321 6.35e-27

melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320216 [Multi-domain]  Cd Length: 278  Bit Score: 108.31  E-value: 6.35e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRkIKTNYFIVSLAFADLLVsVLVMPFGAIELVQD-IWFYGEMFCLVRTS 98
Cdd:cd15088     1 VIMPSVFGCICVVGLVGNGIVLYVLVRCSKLR-TAPDIFIFNLAVADLLF-MLGMPFLIHQFAIDgQWYFGEVMCKIITA 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  99 LDVLLTTASIFHLCCISLDRYYAICcQPLVYRNKMTPLRIALMLGGCWVIPmFISFLPImqgWnnigivdvIEKRKFNHN 178
Cdd:cd15088    79 LDANNQFTSTYILTAMSVDRYLAVV-HPIRSTKYRTRFVAKLVNVGLWAAS-FLSILPV---W--------VYSSLIYFP 145
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 179 SNSTFCVFMVNKP-----YAITCSVVAFYIPFLLMVLAYyriyvtakehaqqIQMLQRAgaTSESRPQTADQHSTHRMRT 253
Cdd:cd15088   146 DGTTFCYVSLPSPddlywFTIYHFILGFAVPLVVITVCY-------------ILILHRL--ARGVAPGNQSHGSSRTKRV 210
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 254 etkaAKTLCVIMGCFCFCWAPFFVTNIVDPFIDYTVP--EKVWTAFLWLGYINSGLNPFLYAFLNKSFRR 321
Cdd:cd15088   211 ----TKMVILIVVVFIVCWLPFHVVQLVNLAMNRPTLafEVAYFLSICLGYANSCLNPFVYILVSENFRK 276
7tmA_CCK_R cd15206
cholecystokinin receptors, member of the class A family of seven-transmembrane G ...
20-323 9.15e-27

cholecystokinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320334 [Multi-domain]  Cd Length: 269  Bit Score: 107.48  E-value: 9.15e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIkTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSL 99
Cdd:cd15206     1 ELIIPLYSVIFLLAVVGNILVIVTLVQNKRMRTV-TNVFLLNLAVSDLLLAVFCMPFTLVGQLLRNFIFGEVMCKLIPYF 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 100 DVLLTTASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVIPMFISfLPIMQGWNNIGIvdvieKRKFNHNS 179
Cdd:cd15206    80 QAVSVSVSTFTLVAISLERYFAI-CHPLKSRVWQTLSHAYKVIAGIWLLSFLIM-SPILVFSNLIPM-----SRPGGHKC 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 180 NSTFCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIyvtakehaqqiqmlqragatsesrpqtadqhSTHRMRTETKAAK 259
Cdd:cd15206   153 REVWPNEIAEQAWYVFLDLMLLVIPGLVMSVAYGLI-------------------------------SWTLLEAKKRVIR 201
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1938531436 260 TLCVIMGCFCFCWAPFFVTNIVDPFIDYTVPEKVWTA----FLWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15206   202 MLFVIVVEFFICWTPLYVINTWKAFDPPSAARYVSSTtislIQLLAYISSCVNPITYCFMNKRFRQAF 269
7tmA_ETH-R cd14997
ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...
21-323 1.59e-26

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320128 [Multi-domain]  Cd Length: 294  Bit Score: 107.38  E-value: 1.59e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  21 VLLTFFAMVI-LMAILGNLLVMVAVCRDRQLRKiKTNYFIVSLAFADLLVSVLVMPFGAIEL-VQDIWFYGEMFCLVRTS 98
Cdd:cd14997     1 VLVSVVYGVIfVVGVLGNVLVGIVVWKNKDMRT-PTNIFLVNLSVADLLVLLVCMPVALVETwAREPWLLGEFMCKLVPF 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  99 LDVLLTTASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVIPmFISFLPImqgwnnIGIVDVIEKrKFNHN 178
Cdd:cd14997    80 VELTVAHASVLTILAISFERYYAI-CHPLQAKYVCTKRRALVIIALIWLLA-LLTSSPV------LFITEFKEE-DFNDG 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 179 SNSTFCVFMVNKP----YAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAQQIQmlqragatsesrpQTADQHSTHRMRTE 254
Cdd:cd14997   151 TPVAVCRTPADTFwkvaYILSTIVVFFVVPLAILSGLYSVICRRLVGHPALES-------------RRADAANRHTLRSR 217
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 255 TKAAKTLCVIMGCFCFCWAPFFVTNIvdpFIDYTV--------PEKVWTAFLW---LGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd14997   218 RQVVYMLITVVVLFFVCLLPFRVVTL---WIIFAPdedlqalgLEGYLNLLVFcrvMVYLNSALNPILYNLMSTKFRSAF 294
7tmA_Galanin_R-like cd14971
galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...
20-323 3.47e-26

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320102 [Multi-domain]  Cd Length: 281  Bit Score: 106.40  E-value: 3.47e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIkTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSL 99
Cdd:cd14971     1 WIVPLFFALIFLLGLVGNSLVILVVARNKPMRST-TNLFILNLAVADLTFLLFCVPFTATIYPLPGWVFGDFMCKFVHYF 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 100 DVLLTTASIFHLCCISLDRYYAIcCQPLVYRNKMTPlRIALMLGGC-WVIPMFISflpimqgwnniGIVDVIEKRKFNHN 178
Cdd:cd14971    80 QQVSMHASIFTLVAMSLDRFLAV-VYPLRSLHIRTP-RNALAASGCiWVVSLAVA-----------APVLALHRLRNYTP 146
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 179 SNSTFCVFMVNKP-----YAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAQQIQMLQRAGatsesrpqtadqhsthrmRT 253
Cdd:cd14971   147 GNRTVCSEAWPSRahrraFALCTFLFGYLLPLLLICVCYAAMLRHLWRVAVRPVLSEGSR------------------RA 208
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1938531436 254 ETKAAKTLCVIMGCFCFCWAPFFVTNIVDPFIDYTVPEKVWTAFLW---LGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd14971   209 KRKVTRLVLVVVVLFAACWGPIHAILLLVALGPFPLTYATYALRIWahcLAYSNSAVNPVLYAFLSEHFRKAF 281
7tmA_Kappa_opioid_R cd15091
opioid receptor subtype kappa, member of the class A family of seven-transmembrane G ...
20-323 4.58e-26

opioid receptor subtype kappa, member of the class A family of seven-transmembrane G protein-coupled receptors; The kappa-opioid receptor binds the opioid peptide dynorphin as the primary endogenous ligand. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320219 [Multi-domain]  Cd Length: 282  Bit Score: 105.81  E-value: 4.58e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLrKIKTNYFIVSLAFADLLVSVlVMPFGAIELVQDIWFYGEMFCLVRTSL 99
Cdd:cd15091     1 VIITAVYSVVFVVGLVGNSLVMFVIIRYTKM-KTATNIYIFNLALADALVTT-TMPFQSTVYLMNSWPFGDVLCKIVISI 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 100 DVLLTTASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMQGWNNIGI-VDVIE-KRKFNH 177
Cdd:cd15091    79 DYYNMFTSIFTLTMMSVDRYIAV-CHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREdVDSTEcSLQFPD 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 178 NSNSTFCVFMvnkpyAITCSVVAFYIPFLLMVLAYYRIYVTAKehaqQIQMLqragatSESRPQTadqhsthrmRTETKA 257
Cdd:cd15091   158 DDYSWWDTFM-----KICVFIFAFVIPVLIIIVCYTLMILRLK----SVRLL------SGSREKD---------RNLRRI 213
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1938531436 258 AKTLCVIMGCFCFCWAPFFVTNIVDPFIDYTVPEKVWTAFLW---LGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15091   214 TRLVLVVVAVFVVCWTPIHIFILVEALGSVSHSTAAVSSYYFciaLGYTNSSLNPILYAFLDENFKRCF 282
7tmA_NTSR-like cd14979
neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...
21-323 4.76e-26

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320110 [Multi-domain]  Cd Length: 300  Bit Score: 106.29  E-value: 4.76e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  21 VLLT-FFAMVILMAILGNLLVMVAVCRDRQLRKiKTNYFIVSLAFADLLVSVLVMPFgaiELVQDIWFY----GEMFCLV 95
Cdd:cd14979     1 VLVTaIYVAIFVVGIVGNLLTCIVIARHKSLRT-TTNYYLFSLAVSDLLILLVGLPV---ELYNFWWQYpwafGDGGCKL 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  96 RTSLDVLLTTASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWvipmFISFLPIMQGWNNIGIVDVIEKRKF 175
Cdd:cd14979    77 YYFLFEACTYATVLTIVALSVERYVAI-CHPLKAKTLVTKRRVKRFILAIW----LVSILCAIPILFLMGIQYLNGPLPG 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 176 NHnSNSTFC---VFMVNKPYAI-TCSVVAFYIPFLLMVLAYYRIYVTAKEHaQQIQMLQRAGATSESRPQTADQhsTHRM 251
Cdd:cd14979   152 PV-PDSAVCtlvVDRSTFKYVFqVSTFIFFVLPMFVISILYFRIGVKLRSM-RNIKKGTRAQGTRNVELSLSQQ--ARRQ 227
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1938531436 252 rtetkAAKTLCVIMGCFCFCWAPFFVTNIVDPFID-YTVPEKVWTAFLW-----LGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd14979   228 -----VVKMLGAVVIAFFVCWLPFHAQRLMFSYASkEDTFLFDFYQYLYpisgiLFYLSSAINPILYNLMSSRFRVAF 300
7tmA_PSP24-like cd15213
G protein-coupled receptor PSP24 and similar proteins, member of the class A family of ...
29-322 6.35e-26

G protein-coupled receptor PSP24 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes two human orphan receptors, GPR45 and GPR65, and their closely related proteins found in vertebrates and invertebrates. GPR45 and GPR 65 are also called PSP24-alpha (or PSP24-1) and PSP24-beta (or PSP24-2) in other vertebrates, respectively. These receptors exhibit the highest sequence homology to each other. PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Instead, sphingosine 1-phosphate and dioleoylphosphatidic acid have been shown to act as low affinity agonists for GPR63. PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320341 [Multi-domain]  Cd Length: 262  Bit Score: 105.14  E-value: 6.35e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  29 VILMAILGNLLVMVAVCRDRQLRKiKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSLDVLLTTASI 108
Cdd:cd15213    10 MIFVGFLGNSIVCLIVYQKPAMRS-AINLLLANLAFSDIMLSLVCMPFAAVTIITGRWIFGDIFCRISAMLYWFFVLEGV 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 109 FHLCCISLDRYYAICCQplvyRNKMTPLRIALMLGGCWVIPMFISFLPIMqGWnnigivdviekRKFNHNSNSTFCVF-- 186
Cdd:cd15213    89 AILLIISVDRYLIIVQR----QDKLNPHRAKILIAVSWVLSFCVSFPPLV-GW-----------GKYEFPPRAPQCVLgy 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 187 ---MVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHaqqiqmlqragatsesrpqtadqhsthrmrtETKAAKTLCV 263
Cdd:cd15213   153 tesPADRIYVVLLLVAVFFIPFLIMLYSYFCILNTVRSF-------------------------------KTRAFTTILI 201
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 264 IMGCFCFCWAPFFVTNIVDPFIDY-TVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRA 322
Cdd:cd15213   202 LFIGFSVCWLPYTVYSLLSVFSRYsSSFYVISTCLLWLSYLKSAFNPVIYCWRIKKFREA 261
7tmA_GPR101 cd15215
orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G ...
28-323 2.75e-25

orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G protein-coupled receptors; Gpr101, an orphan GPCR, is predominantly expressed in the brain within discrete nuclei and is predicted to couple to the stimulatory G(s) protein, a potent activator of adenylate cyclase. GPR101 has been implicated in mediating the actions of GnRH-(1-5), a pentapeptide formed by metallopeptidase cleavage of the decapeptide gonadotropin-releasing hormone (GnRH), which plays a critical role in the regulation of the hypothalamic-pituitary-gonadal axis. GnRH-(1-5) acts on GPR101 to stimulate epidermal growth factor (EFG) release and EFG-receptor (EGFR) phosphorylation, leading to enhanced cell migration and invasion in the Ishikawa endometrial cancer cell line. Furthermore, these effects of GnRH-(1-5) are also dependent on enzymatic activation of matrix metallopeptidase-9 (MMP-9). GPR101 is a member of the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320343 [Multi-domain]  Cd Length: 261  Bit Score: 103.39  E-value: 2.75e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  28 MVILMAIL-----GNLLVMVAVCRDRQLRKIkTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSLDVL 102
Cdd:cd15215     3 SVLIVIFLcaslfGNIVLLLVFQRKPQLLQV-ANRFIFNLLVADLLQTVLVMPWVIATSVPLFWPLDSHLCTALVVLMHL 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 103 LTTASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVIPMFISfLPIMQGWNNIgivdviekrKFNHNSNST 182
Cdd:cd15215    82 FAFAGVNTIVVVSVDRYLAI-IHPLSYPTKMTPRRGYLLIYGTWIVSVLQS-TPPLYGWGQA---------AFDERNALC 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 183 FCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAkehaqqiqmlqragatsesrpqtadqhsthRMRTETKAAKTLC 262
Cdd:cd15215   151 SVIWGSSYSYTILSVVSSFVLPVIIMLACYSMVFRAA------------------------------RRCYHCKAAKVIF 200
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1938531436 263 VIMGCFCFCWAPFFVTNIVDPFIDYTVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15215   201 IIIFSYVLSMGPYSFLSVLAVWVDTQVPQWVISIILWLFFLQCCIHPYIYGYMHKSIKKEF 261
7tmA_KiSS1R cd15095
KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of ...
24-323 3.30e-25

KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled KiSS1-derived peptide receptor (GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (previously known as metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. The KiSS1 receptor is coupled to G proteins of the G(q/11) family, which lead to activation of phospholipase C and increase of intracellular calcium. This signaling cascade plays an important role in reproduction by regulating the secretion of gonadotropin-releasing hormone.


Pssm-ID: 320223 [Multi-domain]  Cd Length: 288  Bit Score: 103.52  E-value: 3.30e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  24 TFFAMVILMAILGNLLVMVAVCRDRQLRKIkTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSLDVLL 103
Cdd:cd15095     5 LIFAIIFLVGLAGNSLVIYVVSRHREMRTV-TNYYIVNLAVTDLAFLVCCVPFTAALYATPSWVFGDFMCKFVNYMMQVT 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 104 TTASIFHLCCISLDRYYAICcQPLVYRNKMTPlRIALMLGGCWVIPMFISFLPImqgwnniGIVDVIEKRKFNHNSnsTF 183
Cdd:cd15095    84 VQATCLTLTALSVDRYYAIV-HPIRSLRFRTP-RVAVVVSACIWIVSFLLSIPV-------AIYYRLEEGYWYGPQ--TY 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 184 C--VF---MVNKPYAITCSVVAFYIPFLLMVLAYyriyvtakehaqqIQMLQRAGATSESRPQTADQHSTHRMRTETKAA 258
Cdd:cd15095   153 CreVWpskAFQKAYMIYTVLLTYVIPLAIIAVCY-------------GLILRRLWRRSVDGNNQSEQLSERALRQKRKVT 219
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1938531436 259 KTLCVIMGCFCFCWAPFFVTNI---VDPFIDYTVPEKVW-TAFLWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15095   220 RMVIVVVVLFAICWLPNHVLNLwqrFDPNFPETYATYALkIAALCLSYANSAVNPFVYAFMGENFRKYF 288
7tmA_Peropsin cd15073
retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of ...
31-322 7.42e-25

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors; Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.


Pssm-ID: 320201 [Multi-domain]  Cd Length: 280  Bit Score: 102.51  E-value: 7.42e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  31 LMAILGNLLVMVAVCRDRQLRKiKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSLDVLLTTASIFH 110
Cdd:cd15073    12 IISTISNGIVLVTFVKFRELRT-PTNALIINLAVTDLGVSIIGYPFSAASDLHGSWKFGYAGCQWYAFLNIFFGMASIGL 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 111 LCCISLDRYYAICCQPLvyRNKMTPLRIALMLGGCWVIPMFISFLPIMqGW-----NNIGIVDVIEKRKfnhnSNSTFcv 185
Cdd:cd15073    91 LTVVAVDRYLTICRPDL--GRKMTTNTYTVMILLAWTNAFFWAAMPLV-GWasyalDPTGATCTINWRK----NDSSF-- 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 186 fmvnKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAqqiqmlqRAGATSESRPQTADQHSTHRMrtetkaaktlCVIM 265
Cdd:cd15073   162 ----VSYTMSVIVVNFIVPLAVMFYCYYNVSRFVKKVL-------ASDCLESVNIDWTDQNDVTKM----------SVIM 220
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1938531436 266 GC-FCFCWAPFfvtNIVDPFIDYTVPEKV--WTAFLWLGYINSG--LNPFLYAFLNKSFRRA 322
Cdd:cd15073   221 IVmFLVAWSPY---SIVCLWASFGEPKKIppWMAIIPPLFAKSStfYNPCIYVIANKKFRRA 279
7tmA_ET_R-like cd14977
endothelin receptors and related proteins, member of the class A family of seven-transmembrane ...
27-323 1.26e-24

endothelin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes endothelin receptors, bombesin receptor subtype 3 (BRS-3), gastrin-releasing peptide receptor (GRPR), neuromedin B receptor (NMB-R), endothelin B receptor-like 2 (ETBR-LP-2), and GRP37. The endothelin receptors and related proteins are members of the seven transmembrane rhodopsin-like G-protein coupled receptor family (class A GPCRs) which activate multiple effectors via different types of G protein.


Pssm-ID: 320108 [Multi-domain]  Cd Length: 292  Bit Score: 102.12  E-value: 1.26e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  27 AMVILMAILGNLLVMVAVCRDRQLRKIkTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSLDVLLTTA 106
Cdd:cd14977     8 LVIFAVGIIGNLMVLCIVCTNYYMRSV-PNILIASLALGDLLLLLLCVPLNAYNLLTKDWLFGDVMCKLVPFIQVTSLGV 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 107 SIFHLCCISLDRYYAICcQPLVYRNKMTPLRIALMLGGCWVIPMfISFLPIMQGWNNIGIVDViekrkfnHNSNSTFCVF 186
Cdd:cd14977    87 TVFSLCALSIDRYRAAV-NSMPMQTIGACLSTCVKLAVIWVGSV-LLAVPEAVLSTVARESSL-------DNSSLTVCIM 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 187 MVNKPYAITCS--------VVAFYIPFLLMVLAYYriyVTAKEhaqqiqmLQRAGATSEsrpqtadQHSTHRMRTETKAA 258
Cdd:cd14977   158 KPSTPFAETYPkarswwlfGCYFCLPLAFTAVCYL---LMART-------LIRAAKEYT-------RGTKKHMKQRRQLA 220
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1938531436 259 KTLCVIMGCFCFCWAPFFVTNIVDPFIDYTVPEKVWTAFLWLGYI-------NSGLNPFLYAFLNKSFRRAF 323
Cdd:cd14977   221 KTVLCLVLVFAFCWLPEHISNILRATLYNEVLIDTRSTLDILDLIgqflsffNSCVNPIALYLLSEPFRRAF 292
7tmA_NMBR cd15125
neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
21-323 1.53e-24

neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin B receptor (NMBR), also known as BB1, is a G-protein coupled receptor whose endogenous ligand is the neuropeptide neuromedin B. Neuromedin B is a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. NMBR is widely distributed in the CNS, with especially high levels in olfactory nucleus and thalamic regions. The receptor couples primarily to a pertussis-toxin-insensitive G protein of the Gq/11 family, which leads to the activation of phospholipase C. NMBR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include gastrin-releasing peptide receptor (GRPR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320253 [Multi-domain]  Cd Length: 292  Bit Score: 101.95  E-value: 1.53e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  21 VLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIKtNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSLD 100
Cdd:cd15125     2 VIPSLYLLIITVGLLGNITLVKIFITNSAMRSVP-NIFISSLAAGDLLLLVTCVPVDASRYFYEEWMFGTVGCKLIPVIQ 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 101 VLLTTASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPimqgwnniGIVDVIEKRKFNHNSN 180
Cdd:cd15125    81 LTSVGVSVFTLTALSADRYKAI-VNPMDIQTSSAVLRTCLKAIAIWVVSVLLAVPE--------AVFSEVAHIMPDDNTT 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 181 STFCV------FMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAQQIqmlqragatsesrPQTADQHSTHRMRTE 254
Cdd:cd15125   152 FTACIpypqtdEMHPKIHSVLIFLVYFLIPLAIISIYYYHIAKTLIKSAHNI-------------PGEYSEHSKRQMETR 218
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1938531436 255 TKAAKTLCVIMGCFCFCWAP--------FFVTNIVDPFIDYTVPEKVWTAflwLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15125   219 KRLAKIVLVFVGLFAFCWFPnhvlymyrSFNYNEIDSSLGHMIVTLVARV---LSFCNSCVNPFALYLLSESFRRHF 292
7tmA_Opsin5_neuropsin cd15074
neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...
21-320 2.71e-24

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.


Pssm-ID: 320202 [Multi-domain]  Cd Length: 284  Bit Score: 101.20  E-value: 2.71e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  21 VLLTFFAMVilmAILGNLLVMVAVCRDRQLRKiKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSLD 100
Cdd:cd15074     5 IYLTVIGIL---STLGNGTVLFVLYRRRSKLK-PAELLTVNLAVSDLGISVFGYPLAIISAFAHRWLFGDIGCVFYGFCG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 101 VLLTTASIFHLCCISLDRYYAICCQPlvYRNKMTPLRIALMLGGCWVIPMFISFLPIMqGWNN-----IGIVDVIEKRKF 175
Cdd:cd15074    81 FLFGCCSINTLTAISIYRYLKICHPP--YGPKLSRRHVCIVIVAIWLYALFWAVAPLV-GWGSygpepFGTSCSIDWTGA 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 176 NHNSNStfcvfmvnKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAQQIqmlqragatsesrpQTADQHSTHRMRTET 255
Cdd:cd15074   158 SASVGG--------MSYIISIFIFCYLLPVLIIVFSYVKIIRKVKSSRKRV--------------AGFDSRSKRQHKIER 215
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1938531436 256 KAAKTLCVIMGCFCFCWAPFFVTNIVDPFIDytvPEKVWTAFLWLGYI----NSGLNPFLYAFLNKSFR 320
Cdd:cd15074   216 KVTKVAVLICAGFLIAWTPYAVVSMWSAFGS---PDSVPILASILPALfaksSCMYNPIIYLLFSSKFR 281
7tmA_Delta_opioid_R cd15089
opioid receptor subtype delta, member of the class A family of seven-transmembrane G ...
20-323 3.76e-24

opioid receptor subtype delta, member of the class A family of seven-transmembrane G protein-coupled receptors; The delta-opioid receptor binds the endogenous pentapeptide ligands such as enkephalins and produces antidepressant-like effects. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320217 [Multi-domain]  Cd Length: 281  Bit Score: 100.80  E-value: 3.76e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLrKIKTNYFIVSLAFADLLVSVlVMPFGAIELVQDIWFYGEMFCLVRTSL 99
Cdd:cd15089     1 IAITALYSVVCVVGLLGNVLVMYGIVRYTKM-KTATNIYIFNLALADALATS-TLPFQSAKYLMETWPFGELLCKAVLSI 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 100 DVLLTTASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVIPMFISFlPIMqgwnnigiVDVIEKRKfnhNS 179
Cdd:cd15089    79 DYYNMFTSIFTLTMMSVDRYIAV-CHPVKALDFRTPAKAKLINICIWVLSSGVGV-PIM--------VMAVTKTP---RD 145
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 180 NSTFCVFMVNKP-------YAITCSVVAFYIPFLLMVLAYyriyvtakehAQQIQMLQRAGATSESRPQTADQHSTHRMr 252
Cdd:cd15089   146 GAVVCMLQFPSPswywdtvTKICVFIFAFVVPILVITVCY----------GLMILRLRSVRLLSGSKEKDRNLRRITRM- 214
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1938531436 253 tetkaaktLCVIMGCFCFCWAPFFVTNIVDPFID------YTVpeKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15089   215 --------VLVVVAAFIICWTPIHIFVIVWTLVDidrrnpLVV--AALHLCIALGYANSSLNPVLYAFLDENFKRCF 281
7tmA_Adenosine_R_A1 cd15071
adenosine receptor subtype A1, member of the class A family of seven-transmembrane G ...
21-323 4.27e-24

adenosine receptor subtype A1, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine A1 receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand. The A1 receptor has primarily inhibitory function on the tissues in which it is located. The A1 receptor slows metabolic activity in the brain and has a strong anti-adrenergic effects in the heart. Thus, it antagonizes beta1-adrenergic receptor-induced stimulation and thereby reduces cardiac contractility. The A1 receptor preferentially couples to G proteins of the G(i/o) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels.


Pssm-ID: 341323 [Multi-domain]  Cd Length: 290  Bit Score: 100.69  E-value: 4.27e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  21 VLLTFFAMVILMAILGNLLVMVAVCRDRQLRKiKTNYFIVSLAFADLLVSVLVMPFG-AIELVQDIWFYGemfCLVRTSL 99
Cdd:cd15071     2 AYIGIEVLIALVSVPGNVLVIWAVKVNQALRD-ATFCFIVSLAVADVAVGALVIPLAiIINIGPQTEFYS---CLMVACP 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 100 DVLLTTASIFHLCCISLDRYYAICCqPLVYRNKMTPLRIALMLGGCWVIPMFISFLPiMQGWNNIGIVDVIEKRKFNHNS 179
Cdd:cd15071    78 VLILTQSSILALLAIAVDRYLRVKI-PTRYKSVVTPRRAAVAIAGCWILSFLVGLTP-MFGWNNLNAVERAWAANSSMGE 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 180 NSTFCVF--MVNKPYAITCSVVAFYI-PFLLMVLAYYRIYVTAKEHaqqiqmLQRAGATSESRPQTADQhsthrmrTETK 256
Cdd:cd15071   156 LVIKCQFetVISMEYMVYFNFFVWVLpPLLLMLLIYLEVFYLIRKQ------LNKKVSSSSSDPQKYYG-------KELK 222
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1938531436 257 AAKTLCVIMGCFCFCWAPFFVTNIVDPFIDYTVPEKVWTAF-LWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15071   223 IAKSLALILFLFALSWLPLHILNCITLFCPSCKKPMILTYIaIFLTHGNSAMNPIVYAFRIKKFRTTF 290
7tmA_Bombesin_R-like cd15927
bombesin receptor subfamily, member of the class A family of seven-transmembrane G ...
20-323 4.72e-24

bombesin receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This bombesin subfamily of G-protein coupled receptors consists of neuromedin B receptor (NMBR), gastrin-releasing peptide receptor (GRPR), and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple mainly to the G proteins of G(q/11) family. NMBR functions as the receptor for the neuropeptide neuromedin B, a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. Gastrin-releasing peptide is an endogenous ligand for GRPR and shares high sequence homology with NMB in the C-terminal region. Both NMB and GRP possess bombesin-like biochemical properties. BRS-3 is classified as an orphan receptor and suggested to play a role in sperm cell division and maturation. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. The bombesin receptor family belongs to the seven transmembrane rhodopsin-like G-protein coupled receptors (class A GPCRs), which perceive extracellular signals and transduce them to guanine nucleotide-binding (G) proteins.


Pssm-ID: 320593 [Multi-domain]  Cd Length: 294  Bit Score: 100.42  E-value: 4.72e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIKtNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSL 99
Cdd:cd15927     1 YVVPILFALIFLVGVLGNGTLILIFLRNKSMRNVP-NIFILSLALGDLLLLLTCVPFTSTIYTLDSWPFGEFLCKLSEFL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 100 DVLLTTASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVIPM-------FISFLPIMQGWNNIGIVDVIek 172
Cdd:cd15927    80 KDTSIGVSVFTLTALSADRYFAI-VNPMRKHRSQATRRTLVTAASIWIVSIllaipeaIFSHVVTFTLTDNQTIQICY-- 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 173 rKFNHNSNSTFCVFMVnkpyaITCSVVAFYIPfLLMVLAYYriyvtakehaqqIQMLQRAGATSESRPQTADQHSTHRMR 252
Cdd:cd15927   157 -PYPQELGPNYPKIMV-----LLRFLVYYLIP-LLIIGVFY------------VLMARHLIRSTRNIGSGQNQAAQRQIE 217
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1938531436 253 TETKAAKTLCVIMGCFCFCWAPFFVTNI-----VDPFIDYTVPEKVWTAFLW-LGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15927   218 ARKKVAKTVLAFVVLFAVCWLPRHVFMLwfhfaPNGLVDYNAFWHVLKIVGFcLSFINSCVNPVALYLLSGSFRRHF 294
7tmA_Mu_opioid_R cd15090
opioid receptor subtype mu, member of the class A family of seven-transmembrane G ...
20-323 4.89e-24

opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors; The mu-opioid receptor binds endogenous opioids such as beta-endorphin and endomorphin. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320218 [Multi-domain]  Cd Length: 279  Bit Score: 100.45  E-value: 4.89e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLrKIKTNYFIVSLAFADLLVSVlVMPFGAIELVQDIWFYGEMFCLVRTSL 99
Cdd:cd15090     1 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKM-KTATNIYIFNLALADALATS-TLPFQSVNYLMGTWPFGNILCKIVISI 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 100 DVLLTTASIFHLCCISLDRYYAIcCQPLVYRNKMTPlRIALMLGGC-WVIPMFISfLPIMqgwnnigivdVIEKRKfnHN 178
Cdd:cd15090    79 DYYNMFTSIFTLCTMSVDRYIAV-CHPVKALDFRTP-RNAKIVNVCnWILSSAIG-LPVM----------FMATTK--YR 143
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 179 SNSTFCVFMVNKP-------YAITCSVVAFYIPFLLMVLAYYRIYVTAKehaqQIQMLqragatsesrpqtadQHSTHRM 251
Cdd:cd15090   144 QGSIDCTLTFSHPswywenlLKICVFIFAFIMPVLIITVCYGLMILRLK----SVRML---------------SGSKEKD 204
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1938531436 252 RTETKAAKTLCVIMGCFCFCWAPFFVTNIVDPFIdyTVPEKVWTAFLW-----LGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15090   205 RNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALV--TIPETTFQTVSWhfciaLGYTNSCLNPVLYAFLDENFKRCF 279
7tmA_GPR45 cd15403
G protein-coupled receptor 45, member of the class A family of seven-transmembrane G ...
20-322 7.69e-24

G protein-coupled receptor 45, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the human orphan receptor GPR45 and closely related proteins found in vertebrates. GPR45 is also called PSP24 in Xenopus and PSP24-alpha (or PSP24-1) in mammals. GPR45 shows the highest sequence homology with GPR63 (PSP24-beta, or PSP24-2). PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Mammalian PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320525 [Multi-domain]  Cd Length: 301  Bit Score: 100.31  E-value: 7.69e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKiKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSL 99
Cdd:cd15403     1 ILLAIVMILMIAIGFLGNAIVCLIVYQKPAMRS-AINLLLATLAFSDIMLSLLCMPFTAVTIITVDWHFGAHFCRISAML 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 100 DVLLTTASIFHLCCISLDRYYAIccqpLVYRNKMTPLRIALMLGGCWVIPMFISFlPIMQGWNnigIVDViekrkfnhNS 179
Cdd:cd15403    80 YWFFVLEGVAILLIISVDRFLII----VQRQDKLNPHRAKVMIAISWVLSFCISF-PSVVGWT---LVEV--------PA 143
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 180 NSTFCV-----FMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAQQIQ---------MLQRAGATSESRPQTADQ 245
Cdd:cd15403   144 RAPQCVlgyteSPADRVYAVLLVVAVFFVPFSIMLYSYLCILNTVRRNAVRIHnhadslclsQVSKLGLMGLQRPHQMNV 223
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 246 HsthrMRTETKAAKTLCVIMGCFCFCWAPFFVTNIVDPFID--YTVPE--KVWTAFLWLGYINSGLNPFLYAFLNKSFRR 321
Cdd:cd15403   224 D----MSFKTRAFTTILILFVGFSLCWLPHTVFSLLSVFSRrfYYSSSfyPISTCVLWLSYLKSVFNPVIYCWRIKKFRE 299

                  .
gi 1938531436 322 A 322
Cdd:cd15403   300 A 300
7tmA_Mel1B cd15400
melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
34-323 8.72e-24

melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320522 [Multi-domain]  Cd Length: 279  Bit Score: 99.54  E-value: 8.72e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  34 ILGNLLVMVAVCRDRQLRKiKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSLDVLLTTASIFHLCC 113
Cdd:cd15400    15 ILGNLLVIISVFRNRKLRN-SGNVFVVSLALADLVVALYPYPLVLVAIFHNGWALGEMHCKVSGFVMGLSVIGSIFNITG 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 114 ISLDRYYAIC---CQPLVYRNKMTPLRIALMlggcWVIPMfisflpimqgwnnIGIVDVIEKRKFNHNSNSTFCVFM--V 188
Cdd:cd15400    94 IAINRYCYIChsfAYDKLYSRWNTLLYVCLI----WALTV-------------VAIVPNFFVGSLEYDPRIYSCTFVqtA 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 189 NKPYAITCSVVAFYIPFLLMVLAYYRIYVTAkehaqqIQMLQRagATSESRPqtadqhsthRMR-TETKAAKTLCVIMGC 267
Cdd:cd15400   157 SSSYTIAVVVIHFIVPITVVSFCYLRIWVLV------IQVRRK--VKSESKP---------RLKpSDFRNFLTMFVVFVI 219
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 268 FCFCWAPF----FVTNIVDPFIDYTVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15400   220 FAICWAPLnligLAVAINPQEMAPKVPEWLFVVSYFMAYFNSCLNAIIYGLLNQNFRKEY 279
7tmA_GPR61_GPR62-like cd15220
G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G ...
23-320 5.55e-23

G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the orphan receptors GPR61 and GPR62, which are both constitutively active and predominantly expressed in the brain. While GPR61 couples to G(s) subtype of G proteins, the signaling pathway and function of GPR 62 are unknown. GPR61-deficient mice displayed significant hyperphagia and heavier body weight compared to wild-type mice, suggesting that GPR61 is involved in the regulation of food intake and body weight. GPR61 transcript expression was found in the caudate, putamen, and thalamus of human brain, whereas GPR62 transcript expression was found in the basal forebrain, frontal cortex, caudate, putamen, thalamus, and hippocampus. Both receptors share the highest sequence homology with each other and comprise a conserved subgroup within the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. Members of this subgroup contain [A/E]RY motif, a variant of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the class A GPCRs and important for efficient G protein-coupled signal transduction.


Pssm-ID: 410633 [Multi-domain]  Cd Length: 264  Bit Score: 97.14  E-value: 5.55e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  23 LTFFAMVILMAILGNLLVMVAVCRDRQLRKIktnYFIVSLAFADLLVSVLVMPFGAI--ELVQDIWFYGEMFCLVRTSLD 100
Cdd:cd15220     3 LFCMVLLDLTALVGNTAVMVVIAKTPHLRKF---AFVCHLCVVDLLAALLLMPLGILssSPFFLGVVFGEAECRVYIFLS 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 101 VLLTTASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMQGWNNIGIVDVIEKRKFNHNSN 180
Cdd:cd15220    80 VCLVSASILTISAISVERYYYI-VHPMRYEVKMTIGLVAAVLVGVWVKALLLGLLPVLGWPSYGGPAPIAARHCSLHWSH 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 181 STFCvfmvnKPYAITCSVVAFYIPFLLMVLAYYRIYvtakehaqqiqmlqragatsesrpqtadqhsthRMRTETKAAKT 260
Cdd:cd15220   159 SGHR-----GVFVVLFALVCFLLPLLLILVVYCGVF---------------------------------KVFGGGKAALT 200
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1938531436 261 LCVIMGCFCFCWAPFFVTNIVDPFIDYTV-PEKVWTAFLWLGYINSGLNPFLYAFLNKSFR 320
Cdd:cd15220   201 LAAIVGQFLCCWLPYFAFHLYSALAASPVsGGEAEEVVTWLAYSCFAVNPFFYGLLNRQIR 261
7tmA_Vasopressin-like cd14986
vasopressin receptors and its related G protein-coupled receptors, member of the class A ...
27-320 5.78e-23

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.


Pssm-ID: 320117 [Multi-domain]  Cd Length: 295  Bit Score: 97.45  E-value: 5.78e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  27 AMVILMAILGNLLVMVAVCRDRQlRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSLDVLLTTA 106
Cdd:cd14986     8 GVLFVFTLVGNGLVILVLRRKRK-KRSRVNIFILNLAIADLVVAFFTVLTQIIWEATGEWVAGDVLCRIVKYLQVVGLFA 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 107 SIFHLCCISLDRYYAIcCQPLvyRNKMTPLRIALMLGGCWVIPmFISFLPimqgwnNIGIVDVIEKRKFNHNSNSTFCVF 186
Cdd:cd14986    87 STYILVSMSLDRYQAI-VKPM--SSLKPRKRARLMIVVAWVLS-FLFSIP------QLVIFVERELGDGVHQCWSSFYTP 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 187 MVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAQQIQMLQRAGATSESRPQTADQHSTHR-MRTETKAAK-TLCVI 264
Cdd:cd14986   157 WQRKVYITWLATYVFVIPLIILSYCYGRILRTIWIRSRQKTDRPIAPTAMSCRSVSCVSSRVSLiSRAKIKTIKmTLVII 236
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1938531436 265 MGcFCFCWAPFFVTNIVDPFIDYT-VPEKVWTAFLWLGYINSGLNPFLYAFLNKSFR 320
Cdd:cd14986   237 LA-FILCWTPYFIVQLLDVYAGMQqLENDAYVVSETLASLNSALNPLIYGFFSSHLS 292
7tmA_Opsin_Gq_invertebrates cd15337
invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled ...
24-323 1.02e-22

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The invertebrate Gq-coupled opsin subfamily includes the arthropod and mollusc visual opsins. Like the vertebrate visual opsins, arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. The invertebrate Gq opsins are closely related to the vertebrate melanopsins, the primary photoreceptor molecules for non-visual responses to light, and the R1-R6 photoreceptors, which are the fly equivalent to the vertebrate rods. The Gq opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320459 [Multi-domain]  Cd Length: 292  Bit Score: 97.01  E-value: 1.02e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  24 TFFAMVILMAILGNLLVMVAVCRDRQLRKiKTNYFIVSLAFADLLVS-VLVMPFGAIELVQDIWFYGEMFCLVRTSLDVL 102
Cdd:cd15337     5 IYIAIVGILGVIGNLLVIYLFSKTKSLRT-PSNMFIINLAISDFGFSaVNGFPLKTISSFNKKWIWGKVACELYGFAGGI 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 103 LTTASIFHLCCISLDRYYAICcQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMqGWNNIGIVDVIEKRKFNHNSNSt 182
Cdd:cd15337    84 FGFMSITTLAAISIDRYLVIA-KPLEAMKKMTFKRAFIMIIIIWLWSLLWSIPPFF-GWGRYVPEGFQTSCTFDYLSRD- 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 183 fcvfMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAQQIQMLQRAGATSESRPQTADQhsthrmRTETKAAKTLC 262
Cdd:cd15337   161 ----LNNRLFILGLFIFGFLCPLLIIIFCYVNIIRAVRNHEKEMTQTAKSGMGKDTEKNDARK------KAEIRIAKVAI 230
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1938531436 263 VIMGCFCFCWAPFFVTNIV-----DPFIDYTVPE------KvwTAFLWlgyinsglNPFLYAFLNKSFRRAF 323
Cdd:cd15337   231 ILISLFLLSWTPYAVVALLgqfgpAYWITPYVSElpvmfaK--ASAIY--------NPIIYALSHPKFRAAL 292
7tmA_GPR83 cd15389
G protein-coupled receptor 83, member of the class A family of seven-transmembrane G ...
20-322 1.06e-22

G protein-coupled receptor 83, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR83, also known as GPR72, is widely expressed in the brain, including hypothalamic nuclei which is involved in regulating energy balance and food intake. The hypothalamic expression of GPR83 is tightly regulated in response to nutrient availability and is decreased in obese mice. A recent study suggests that GPR83 has a critical role in the regulation of systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms. GPR83 shares a significant amino acid sequence identity with the tachykinin receptors, however its endogenous ligand is unknown.


Pssm-ID: 320511 [Multi-domain]  Cd Length: 285  Bit Score: 96.64  E-value: 1.06e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIkTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSL 99
Cdd:cd15389     1 ALLIVAYSIIIVISLFGNSLVCHVIFKNKRMHTA-TNLFIVNLAVSDILITLLNTPFTLVRFVNSTWVFGKIMCHLSRFA 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 100 DVLLTTASIFHLCCISLDRYYAICCqPLvyRNKMTPLRIALMLGGCWVIPMFISfLP--IMQgwnnigivdviEKRKFNH 177
Cdd:cd15389    80 QYCSVYVSTLTLTAIALDRHRVILH-PL--KPRITPCQGVVVIAIIWIMASCLS-LPhaIYQ-----------KLVEFEY 144
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 178 NSNSTFCVFMVNKPYA---------ITCSVVAFYIPFLLMVLAYYRIyvtakehAQQIQMLQRAGATsesrpqTADQHST 248
Cdd:cd15389   145 SNERTRSRCLPSFPEPsdlfwkyldLATFILQYVLPLLIIGVAYTRV-------AKKLWLRNAIGDV------TTEQYVA 211
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1938531436 249 HRmRTETKAAKTLCVIMGCFCFCWAPFFVTNIVDPFIDYTVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRA 322
Cdd:cd15389   212 QR-RKKKKTIKMLMLVVLLFAICWLPLNCYHVLLSSHPIRSNSALFFAFHWLAMSSTCYNPFIYCWLNDSFRSE 284
7tmA_GnRHR-like cd15195
gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A ...
21-323 1.34e-22

gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Gonadotropin-releasing hormone (GnRH) and adipokinetic hormone (AKH) receptors share strong sequence homology to each other, suggesting that they have a common evolutionary origin. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flying, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320323 [Multi-domain]  Cd Length: 293  Bit Score: 96.70  E-value: 1.34e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  21 VLLTFFAMVILMAilGNLLVMVAVCRDRQlRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSLD 100
Cdd:cd15195     4 VLVTWVLFVISAA--GNLTVLIQLFRRRR-AKSHIQILIMHLALADLMVTFFNMPMDAVWNYTVEWLAGDLMCRVMMFLK 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 101 VLLTTASIFHLCCISLDRYYAIcCQPLVyRNKmTPLRIALMLGGCWV------IPMFISFLPIMQGWNNIGIVDVIEKRK 174
Cdd:cd15195    81 QFGMYLSSFMLVVIALDRVFAI-LSPLS-ANQ-ARKRVKIMLTVAWVlsalcsIPQSFIFSVLRKMPEQPGFHQCVDFGS 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 175 FNHNSNStfcvfmvnKPYAITCSVVAFYIPFLLMVLAYYRIYVTAkehaqqIQMLQRAGATSESRPQTADQHSTHRMRTE 254
Cdd:cd15195   158 APTKKQE--------RLYYFFTMILSFVIPLIITVTCYLLILFEI------SKMAKRARDTPISNRRRSRTNSLERARMR 223
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1938531436 255 TKAAKTLCVIMgcFCFCWAPFFVTNI---VDPFIDYTVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15195   224 TLRMTALIVLT--FIVCWGPYYVLGLwywFDKESIKNLPPALSHIMFLLGYLNPCLHPIIYGVFMKEIRNWI 293
7tmA_GPR63 cd15404
G protein-coupled receptor 63, member of the class A family of seven-transmembrane G ...
20-322 1.38e-22

G protein-coupled receptor 63, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the human orphan receptor GPR63, which is also called PSP24-beta or PSP24-2, and its closely related proteins found in vertebrates. GPR63 shares the highest sequence homology with GPR45 (Xenopus PSP24, mammalian PSP24-alpha or PSP24-1). PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Mammalian PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320526 [Multi-domain]  Cd Length: 265  Bit Score: 96.06  E-value: 1.38e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKiKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSL 99
Cdd:cd15404     1 VILSAVMIFILLVSFLGNFVVCLMVYQKAAMRS-AINILLASLAFADMMLAVLNMPFALVTIITTRWIFGDAFCRVSAMF 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 100 DVLLTTASIFHLCCISLDRYYAICCQplvyRNKMTPLRIALMLGGCWVIPMFISFlPIMQGWNNIGIVDVIEKRKFNHNS 179
Cdd:cd15404    80 FWLFVMEGVAILLIISIDRFLIIVQK----QDKLNPYRAKVLIAVSWAVSFCVAF-PLAVGSPDLQIPSRAPQCVFGYTT 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 180 NSTFcvfmvnKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHaqqiqmlqragatsesrpqtadqhsthrmrtETKAAK 259
Cdd:cd15404   155 NPGY------QAYVILIMLIFFFIPFMVMLYSFMGILNTVRSF-------------------------------KTRAFT 197
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1938531436 260 TLCVIMGCFCFCWAPFFVTNIVDPFIDYTVPE----KVWTAFLWLGYINSGLNPFLYAFLNKSFRRA 322
Cdd:cd15404   198 TILILFIVFTVCWAPFTTYSLVATFNSHFYHKhnffEISTWLLWLCYLKSALNPLIYYWRIKKFRDA 264
7tmA_Gal1_R cd15098
galanin receptor subtype 1, member of the class A family of seven-transmembrane G ...
20-323 1.73e-22

galanin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320226 [Multi-domain]  Cd Length: 282  Bit Score: 95.95  E-value: 1.73e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIK-TNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTS 98
Cdd:cd15098     1 VIVPVVFGLIFCLGVLGNSLVITVLARVKPGKRRStTNVFILNLSIADLFFLLFCVPFQATIYSLPEWVFGAFMCKFVHY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  99 LDVLLTTASIFHLCCISLDRYYAIccqplVYRNKMTPLRIA----LMLGGCWVIPMFISfLPIMQgwnNIGIVDVIEKrk 174
Cdd:cd15098    81 FFTVSMLVSIFTLVAMSVDRYIAV-----VHSRTSSSLRTRrnalLGVLVIWVLSLAMA-SPVAV---HQDLVHHWTA-- 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 175 fnhnSNSTFCV-----FMVNKPYAITCSVVAFYIPFLLMVLAYYRIyvtakehaqqiqmLQRAGATSESRPQTADqhsth 249
Cdd:cd15098   150 ----SNQTFCWenwpeKQQKPVYVVCTFVFGYLLPLLLITFCYAKV-------------LNHLHKKLKNMSKKSE----- 207
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1938531436 250 rmRTETKAAKTLCVIMGCFCFCWAPFFVTNIVDPFIDYTVPEKVWTAFLW---LGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15098   208 --RSKKKTAQTVLVVVVVFGISWLPHHIIHLWVEFGDFPLTQASFVLRITahcLAYANSCVNPIIYAFLSENFRKAY 282
7tmA_Angiotensin_R-like cd14985
angiotesin receptor family and its related G protein-coupled receptors, member of the class A ...
20-323 1.91e-22

angiotesin receptor family and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the angiotensin receptors, the bradykinin receptors, apelin receptor as well as putative G-protein coupled receptors (GPR15 and GPR25). Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2 receptor, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Bradykinins (BK) are pro-inflammatory peptides that mediate various vascular and pain responses to tissue injury through its B1 and B2 receptors. Apelin (APJ) receptor binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body, and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake. Orphan receptors, GPR15 and GPR25, share strong sequence homology to the angiotensin II type AT1 and AT2 receptors.


Pssm-ID: 341320 [Multi-domain]  Cd Length: 284  Bit Score: 95.91  E-value: 1.91e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIkTNYFIVSLAFADLLVsVLVMPFGAI-ELVQDIWFYGEMFCLVRTS 98
Cdd:cd14985     1 VVIPALYIAIFLVGLLGNLFVVWVFLFPRGPKRV-ADIFIANLAAADLVF-VLTLPLWATyTANQYDWPFGAFLCKVSSY 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  99 LDVLLTTASIFHLCCISLDRYYAICcQPLVYRNKMTPLRIALMLGGCWVIPMFISfLPIMqgwnnigivdVIEKRKFNHN 178
Cdd:cd14985    79 VISVNMFASIFLLTCMSVDRYLAIV-HPVASRRLRRRRQARVTCALIWVVACLLS-LPTF----------LLRSLQAIEN 146
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 179 SNSTFCVFMVNKP-----YAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAQQIQmlqragatsesrpqtadqhstHRMRT 253
Cdd:cd14985   147 LNKTACIMLYPHEawhfgLSLELNILGFVLPLLIILTCYFHIARSLRKRYERTG---------------------KNGRK 205
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1938531436 254 ETKAAKTLCVIMGCFCFCWAPFFVTNIVDPFIDY-TVPEKVWTAFLWLG--------YINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd14985   206 RRKSLKIIFALVVAFLVCWLPFHFFKFLDFLAQLgAIRPCFWELFLDLGlpiatclaFTNSCLNPFIYVFVDRRFRQKV 284
7tmA_Mel1C cd15401
melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G ...
20-323 2.23e-22

melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320523 [Multi-domain]  Cd Length: 279  Bit Score: 95.75  E-value: 2.23e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKiKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSL 99
Cdd:cd15401     1 SVLAGVLIFTIVVDVLGNLLVILSVLRNKKLRN-AGNIFVVSLSVADLVVAVYPYPLILLAIFHNGWTLGNIHCQISGFL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 100 DVLLTTASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVIPMfisflpimqgwnnIGIVDVIEKRKFNHNS 179
Cdd:cd15401    80 MGLSVIGSVFNITAIAINRYCYI-CHSLRYDKLYNMKKTCCYVCLTWVLTL-------------AAIVPNFFVGSLQYDP 145
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 180 NSTFCVF--MVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAkehaqqIQMLQRAGATSESRPQTADqhsthrmrteTKA 257
Cdd:cd15401   146 RIYSCTFaqTVSSSYTITVVVVHFIVPLSIVTFCYLRIWVLV------IQVKHRVRQDSKQKLKAND----------IRN 209
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 258 AKTLCVIMGCFCFCWAPFFVTNI---VDPF-IDYTVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15401   210 FLTMFVVFVLFAVCWGPLNFIGLavaINPLkVAPKIPEWLFVLSYFMAYFNSCLNAVIYGVLNQNFRKEY 279
7tmA_Mel1A cd15402
melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
22-323 2.90e-22

melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320524 [Multi-domain]  Cd Length: 279  Bit Score: 95.36  E-value: 2.90e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  22 LLTFFAMVILMAILGNLLVMVAVCRDRQLRKiKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSLDV 101
Cdd:cd15402     3 LACILIFTIVVDILGNLLVILSVYRNKKLRN-AGNIFVVSLAVADLVVAIYPYPLVLTSIFHNGWNLGYLHCQISGFLMG 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 102 LLTTASIFHLCCISLDRYYAIcCQPLVYrNKMTPLRIALmlggCWVIPMFISFLpimqgwnnIGIVDVIEKRKFNHNSNS 181
Cdd:cd15402    82 LSVIGSIFNITGIAINRYCYI-CHSLKY-DKLYSDKNSL----CYVLLIWVLTV--------AAIVPNLFVGSLQYDPRI 147
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 182 TFCVFMVNKPYAITCSVVAFY--IPFLLMVLAYYRIYVTAkehaqqIQMLQRAgatsesRPQTADQHSTHRMRTETkaak 259
Cdd:cd15402   148 YSCTFAQSVSSAYTIAVVFFHfiLPIIIVTFCYLRIWILV------IQVRRRV------KPDNKPKLKPHDFRNFV---- 211
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1938531436 260 TLCVIMGCFCFCWAPFFVTNI---VDP-FIDYTVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15402   212 TMFVVFVLFAVCWAPLNFIGLavaVDPeTIVPRIPEWLFVASYYMAYFNSCLNAIIYGLLNQNFRREY 279
7tmA_Melanopsin cd15336
vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G ...
24-322 3.02e-22

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G protein-coupled receptors; Melanopsin (also called Opsin-4) is the G protein-coupled photopigment that mediates non-visual responses to light. In mammals, these photoresponses include the photo-entrainment of circadian rhythm, pupillary constriction, and acute nocturnal melatonin suppression. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. Melanopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320458 [Multi-domain]  Cd Length: 290  Bit Score: 95.55  E-value: 3.02e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  24 TFFAMVILMAILGNLLVMVAVCRDRQLRKiKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSLDVLL 103
Cdd:cd15336     5 SVILIIGITGMLGNALVIYAFCRSKKLRT-PANYFIINLAVSDFLMSLTQSPIFFVNSLHKRWIFGEKGCELYAFCGALF 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 104 TTASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMqGWNNIgivdVIEKRKfnhnsnsTF 183
Cdd:cd15336    84 GITSMITLLAISLDRYLVI-TKPLASIRWVSKKRAMIIILLVWLYSLAWSLPPLF-GWSAY----VPEGLL-------TS 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 184 CVF------MVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAQQIQMLqragaTSESRPQTADQHstHRMRTETKA 257
Cdd:cd15336   151 CTWdymtftPSVRAYTMLLFCFVFFIPLGIIIYCYLFIFLAIRSTGREVQKL-----GSQDRKEKAKQY--QRMKNEWKM 223
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1938531436 258 AKTLCVIMGCFCFCWAPFFV---------TNIVDPFIDyTVPEKVWTAflwlgyiNSGLNPFLYAFLNKSFRRA 322
Cdd:cd15336   224 AKIAFVVILLFVLSWSPYACvaliawagyAHLLTPYMK-SVPAVIAKA-------SAIYNPIIYAITHPKYREA 289
7tmA_photoreceptors_insect cd15079
insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...
22-281 3.39e-22

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320207 [Multi-domain]  Cd Length: 292  Bit Score: 95.34  E-value: 3.39e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  22 LLTFFAMVILMAILGNLLVMVAVCRDRQLRKiKTNYFIVSLAFADLLVsVLVMPFGAIELVQDIWFYGEMFCLVRTSLDV 101
Cdd:cd15079     3 LGFIYIFLGIVSLLGNGLVIYIFSTTKSLRT-PSNMLVVNLAISDFLM-MIKMPIFIYNSFYEGWALGPLGCQIYAFLGS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 102 LLTTASIFHLCCISLDRYYAICCqPLVyRNKMTPLRIALMLGGCWVIPMFISFLPIMQGWNnigivdviekrKFNHNSNS 181
Cdd:cd15079    81 LSGIGSIWTNAAIAYDRYNVIVK-PLN-GNPLTRGKALLLILFIWLYALPWALLPLLFGWG-----------RYVPEGFL 147
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 182 TFCVF------MVNKPYAITCSVVAFYIPFLLMVLAYYRI--YVTAKEHAQQIQMLQRAGATSESRPQTADQhsthrmRT 253
Cdd:cd15079   148 TSCSFdyltrdWNTRSFVATIFVFAYVIPLIIIIYCYSFIvkAVFAHEKALREQAKKMNVVSLRSNADANKQ------SA 221
                         250       260
                  ....*....|....*....|....*...
gi 1938531436 254 ETKAAKTLCVIMGCFCFCWAPFFVTNIV 281
Cdd:cd15079   222 EIRIAKVALTNVFLWFIAWTPYAVVALI 249
7tmA_NPR-like_invertebrate cd15391
invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G ...
22-320 5.31e-22

invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor found in invertebrates, which is a member of class A of 7-transmembrane G protein-coupled receptors. This orphan receptor shares a significant amino acid sequence identity with the neurokinin 1 receptor (NK1R). The endogenous ligand for NK1R is substance P, an 11-amino acid peptide that functions as a vasodilator and neurotransmitter and is released from the autonomic sensory nerve fibers.


Pssm-ID: 320513 [Multi-domain]  Cd Length: 289  Bit Score: 94.89  E-value: 5.31e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  22 LLTFFAMVILMAILGNLLVMVAVCRDRQLRKiKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSLDV 101
Cdd:cd15391     3 LINLYQSTIFLSVGGNYSVIVVFYDGRRSRT-DLNYYLINLAVSDLIMALFCMPFTFTQIMLGHWVFPAPMCPIVLYVQL 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 102 LLTTASIFHLCCISLDRYYAIcCQPLvyRNKMTPLRIALMLGGCWVIPMFISFLPI------MQGWNNIGIVDVIEKRKF 175
Cdd:cd15391    82 VSVTASVLTNTAIGIDRFFAV-IFPL--RSRHTKSRTKCIIASIWAISFSLSSVQLfagrtqRYGQYSEGRVLCGESWPG 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 176 NHNSNSTFCVFMVnkpyaitcsVVAFYIPFLLMVLAYyrIYVTAKEHAQQIqmlqragatsesrPQTADQ-HSTHRMRTE 254
Cdd:cd15391   159 PDTSRSAYTVFVM---------LLTYIIPLLILTSTY--GYVGFRLWNRTA-------------PGNADKgRDDMQIKSK 214
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1938531436 255 TKAAKTLCVIMGCFCFCWAPFFVTNIVDPFIDYTVPEK------VWTAFLWLGYINSGLNPFLYAFLNKSFR 320
Cdd:cd15391   215 RKVIKMLVFVVLMFGICWLPLHLFNLVQDFSTVFRNMPqhttrlIYGACHWIAMSNSFVNPIIYLFMNDSFR 286
7tmA_Chemokine_R cd14984
classical and atypical chemokine receptors, member of the class A family of ...
20-321 6.94e-22

classical and atypical chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. In addition to these classical chemokine receptors, there exists a subfamily of atypical chemokine receptors (ACKRs) that are unable to couple to G-proteins and, instead, they preferentially mediate beta-arrestin dependent processes, such as receptor internalization, after ligand binding. The classical chemokine receptors contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. However, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 341319 [Multi-domain]  Cd Length: 278  Bit Score: 94.20  E-value: 6.94e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRkIKTNYFIVSLAFADLLVsVLVMPFGAIELVQDiWFYGEMFCLVRTSL 99
Cdd:cd14984     1 VFLPVLYSLVFLLGLVGNSLVLLVLLYYRKLR-SMTDVYLLNLALADLLF-VLTLPFWAVYAADG-WVFGSFLCKLVSAL 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 100 DVLLTTASIFHLCCISLDRYYAICCQPLVYRNKmTPLRIALMLGGCWVIPMFISFLPIMQGWNNIGIVDVIEKRKFNHNS 179
Cdd:cd14984    78 YTINFYSGILFLACISIDRYLAIVHAVSALRAR-TLLHGKLTCLGVWALALLLSLPEFIFSQVSEENGSSICSYDYPEDT 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 180 NSTFCVFMvnkpyAITCSVVAFYIPFLLMVLAYYRIyvtakehaqqIQMLQRAgatsesrpqtadqhsthRMRTETKAAK 259
Cdd:cd14984   157 ATTWKTLL-----RLLQNILGFLLPLLVMLFCYSRI----------IRTLLRA-----------------RNHKKHRALR 204
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1938531436 260 TLCVIMGCFCFCWAPFFVTNIVDPFIDYTVPE-------KVWTAFLW---LGYINSGLNPFLYAFLNKSFRR 321
Cdd:cd14984   205 VIFAVVVVFFLCWLPYNIVLLLDTLQLLGIISrscelskSLDYALQVtesLAFSHCCLNPVLYAFVGVKFRK 276
7tmA_NPY2R cd15399
neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G ...
20-323 1.43e-21

neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320521 [Multi-domain]  Cd Length: 285  Bit Score: 93.35  E-value: 1.43e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIkTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSL 99
Cdd:cd15399     1 IVLILAYCSIILLGVVGNSLVIYVVIKFKNMRTV-TNFFIANLAVADLMVNTLCLPFTLVYTLLDEWKFGAVLCHLVPYA 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 100 DVLLTTASIFHLCCISLDRYYAIccqplVYR--NKMTPLRIALMLGGCWVIPMFI-SFLPIMQGWNNI------GIVDVI 170
Cdd:cd15399    80 QALAVHVSTVTLTVIALDRHRCI-----VYHleSKISKKISFLIIGLTWAASALLaSPLAIFREYSVIeispdfKIQACS 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 171 EKRKFNHNSNSTFcvfmvnkpYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAQqiqmlqragatsesrPQTADQHSTHR 250
Cdd:cd15399   155 EKWPNGTLNDGTI--------YSVSMLLIQYVLPLAIISYAYIRIWTKLKNHVS---------------PGGGNDHYHQR 211
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1938531436 251 MRtetKAAKTLCVIMGCFCFCWAPF----FVTNIVDPFIDYTVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15399   212 RR---KTTKMLVCVVVVFAVSWLPFhafqLASDIDSKVLDLKEYKLIYTIFHVIAMCSTFANPLLYGWMNNNYRTAF 285
7tmA_SSTR2 cd15971
somatostatin receptor type 2, member of the class A family of seven-transmembrane G ...
20-323 1.66e-21

somatostatin receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin, a polypeptide hormone that regulates a wide variety of physiological such as neurotransmission, endocrine secretion, cell proliferation, and smooth muscle contractility. SSTRs are composed of five distinct subtypes (SSTR1-5) which are encoded by separate genes on different chromosomes. SSTR2 plays critical roles in growth hormone secretion, glucagon secretion, and immune responses. SSTR2 is expressed in the normal human pituitary and in nearly all pituitary growth hormone adenomas.


Pssm-ID: 320637 [Multi-domain]  Cd Length: 279  Bit Score: 93.37  E-value: 1.66e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIkTNYFIVSLAFADLLVsVLVMPFGAIELVQDIWFYGEMFCLVRTSL 99
Cdd:cd15971     1 AFLTFIYFVVCIIGLCGNTLVIYVILRYAKMKTV-TNIYILNLAIADELF-MLGLPFLAIQVALVHWPFGKAICRVVMTV 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 100 DVLLTTASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVIPMFIsFLPIM-----QGWNNIGIVDVIekrk 174
Cdd:cd15971    79 DGINQFTSIFCLTVMSIDRYLAV-VHPIKSAKWRKPRTAKMINMAVWGVSLLV-ILPIMiyagvQTKHGRSSCTII---- 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 175 FNHNSNSTFCVFMVnkpYAItcsVVAFYIPFLLMVLAYYRIYVTAKEHAQQIQmlqragatsesrpqtadqhSTHRMRTE 254
Cdd:cd15971   153 WPGESSAWYTGFII---YTF---ILGFFVPLTIICLCYLFIIIKVKSSGIRVG-------------------SSKRKKSE 207
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1938531436 255 TKAAKTLCVIMGCFCFCWAPFFVTNI--VDPFIDYTVPEK-VWTAFLWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15971   208 KKVTRMVSIVVAVFVFCWLPFYIFNVssVSVSISPTPGLKgMFDFVVVLSYANSCANPILYAFLSDNFKKSF 279
7tmA_S1PR1_Edg1 cd15346
sphingosine-1-phosphate receptor subtype 1 (S1PR1 or S1P1), also called endothelial ...
26-323 1.68e-21

sphingosine-1-phosphate receptor subtype 1 (S1PR1 or S1P1), also called endothelial differentiation gene 1 (Edg1), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320468 [Multi-domain]  Cd Length: 277  Bit Score: 93.02  E-value: 1.68e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  26 FAMVILMAILGNLLVMVAVCRDRQLRKiKTNYFIVSLAFADLLVSV------LVMPFGAIELVQDIWFY--GEMFCLVrt 97
Cdd:cd15346     7 FIIICCFIILENIFVLLTIWKTKKFHR-PMYYFIGNLALSDLLAGVaytanlLLSGATTYKLTPTQWFLreGSMFVAL-- 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  98 sldvlltTASIFHLCCISLDRYYAICCQPLvyRNKMTPLRIALMLGGCWVIPMFISFLPIMqGWNNIgivdviekrkfNH 177
Cdd:cd15346    84 -------SASVFSLLAIAIERYITMLKMKL--HNGSNSFRSFLLISACWVISLILGGLPIM-GWNCI-----------SA 142
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 178 NSNSTFCVFMVNKPYAITCSVVaFYIPFLLMVLAYYRIYVTAKEHAQQIqMLQRAGATSESRPQTAdqhsthrmrteTKA 257
Cdd:cd15346   143 LSSCSTVLPLYHKHYILFCTTV-FTLLLLSIVILYCRIYSLVRTRSRRL-TFRKNIRKASRSSEKS-----------MAL 209
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1938531436 258 AKTLCVIMGCFCFCWAPFFVTNIVDPFIDYTVPEKVWTA--FLWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15346   210 LKTVIIVLSVFIACWAPLFILLLLDVGCKVKTCSILFKAeyFLVLAVLNSATNPIIYTLTNKEMRRAF 277
7tmA_purinoceptor-like cd14982
purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...
20-321 3.90e-21

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341318 [Multi-domain]  Cd Length: 283  Bit Score: 92.33  E-value: 3.90e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKiKTNYFIVSLAFADLLVsVLVMPFGAIE-LVQDIWFYGEMFCLVRTS 98
Cdd:cd14982     1 TLFPIVYSLIFILGLLGNILALWVFLRKMKKRS-PTTIYMINLALADLLF-VLTLPFRIYYyLNGGWWPFGDFLCRLTGL 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  99 LDVLLTTASIFHLCCISLDRYYAICcQPLVYRNKMTPLRIALMLGGCWVIpMFISFLPIMqgwnnigivdvIEKRKFNHN 178
Cdd:cd14982    79 LFYINMYGSILFLTCISVDRYLAVV-HPLKSRRLRRKRYAVGVCAGVWIL-VLVASVPLL-----------LLRSTIAKE 145
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 179 SNSTFC--VFMVNK----PYAITCSVVAFYIPFLLMVLAYYRIyvtakehaqqIQMLqragatseSRPQTADQHSTHRmr 252
Cdd:cd14982   146 NNSTTCfeFLSEWLasaaPIVLIALVVGFLIPLLIILVCYSLI----------IRAL--------RRRSKQSQKSVRK-- 205
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1938531436 253 teTKAAKTLCVIMGCFCFCWAPFFVTNIV-----DPFIDYTVPEKVWTAF----LWLGYINSGLNPFLYAFLNKSFRR 321
Cdd:cd14982   206 --RKALRMILIVLAVFLVCFLPYHVTRILyllvrLSFIADCSARNSLYKAyritLCLASLNSCLDPLIYYFLSKTFRK 281
7tmA_MCHR1 cd15338
melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane ...
20-323 5.02e-21

melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320460 [Multi-domain]  Cd Length: 282  Bit Score: 91.80  E-value: 5.02e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIKT--NYFIVSLAFADLLVsVLVMPFGAIELVQD-IWFYGEMFCLVR 96
Cdd:cd15338     1 VIMPSVFGVICFLGIIGNSIVIYTIVKKSKFRCQQTvpDIFIFNLSIVDLLF-LLGMPFLIHQLLGNgVWHFGETMCTLI 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  97 TSLDVLLTTASIFHLCCISLDRYYAICcQPLVYRNKMTPLRIALMLGGCWVIpmfiSFLPIMQGWNNIGIVDViekrkfn 176
Cdd:cd15338    80 TALDTNSQITSTYILTVMTLDRYLATV-HPIRSTKIRTPRVAVAVICLVWIL----SLLSITPVWMYAGLMPL------- 147
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 177 hNSNSTFCVFMVNKP------YAITCSVVAFYIPFLLMVLAYYRIyvtakehaqqiqmLQRAGATSESRPQTADQHSTHR 250
Cdd:cd15338   148 -PDGSVGCALLLPNPetdtywFTLYQFFLAFALPLVVICVVYFKI-------------LQNMASTVAPLPQRSLRVRTKK 213
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1938531436 251 MrteTKAAKTLCVImgcFCFCWAPFFVTNIVDPFIDYTVPEKV--WTAFLWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15338   214 V---TRMAVAICLA---FFICWAPFYILQLAHLSIDRPSLAFLyaYNVAISMGYANSCINPFLYIMLSETFKRQF 282
7tmA_Mel1 cd15209
melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
30-323 5.77e-21

melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320337 [Multi-domain]  Cd Length: 279  Bit Score: 91.76  E-value: 5.77e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  30 ILMAILGNLLVMVAVCRDRQLRKiKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSLDVLLTTASIF 109
Cdd:cd15209    11 IVVDVLGNLLVILSVLRNKKLRN-AGNIFVVSLSVADLVVAIYPYPLILHAIFHNGWTLGQLHCQASGFIMGLSVIGSIF 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 110 HLCCISLDRYYAICCQ---PLVYRNKMTPLRIALMlggcWVIPMfISFLPIMQgwnnIGIVDviekrkfnHNSNSTFCVF 186
Cdd:cd15209    90 NITAIAINRYCYICHSlqyDRLYSLRNTCCYLCLT----WLLTV-LAVLPNFF----IGSLQ--------YDPRIYSCTF 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 187 --MVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAkehaqqIQMLQRAGATSESRPQTADqhsthrmrteTKAAKTLCVI 264
Cdd:cd15209   153 aqTVSTVYTITVVVIHFLLPLLIVSFCYLRIWVLV------LQVRQRVKPDQRPKLKPAD----------VRNFLTMFVV 216
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1938531436 265 MGCFCFCWAPFFVTNI---VDPF-IDYTVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15209   217 FVLFAVCWAPLNFIGLavaINPKeMAPKIPEWLFVASYFMAYFNSCLNAIIYGLLNQNFRKEY 279
7tmA_GnRHR_invertebrate cd15384
invertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
19-312 5.86e-21

invertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320506 [Multi-domain]  Cd Length: 293  Bit Score: 91.73  E-value: 5.86e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  19 KVVLLtffAMVILMAILGNLLVMVAVCRDRQlRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTS 98
Cdd:cd15384     3 KIVVL---AVMFVISFIGNLLTIIQIYRLRR-SRRTIYSLLLHLAIADLLVTFFCIPSEAIWAYTVAWLAGNTMCKLVKY 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  99 LDVLLTTASIFHLCCISLDRYYAIcCQPLVyRNKMtPLRIALMLGGCWVIPMFISfLP---IMQGWNNIGIVDVIEKRKF 175
Cdd:cd15384    79 LQVFGLYLSTYITVLISLDRCVAI-LYPMK-RNQA-PERVRRMVTVAWILSPIFS-IPqavIFHVERGPFVEDFHQCVTY 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 176 NhnsnsTFCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAQQIQmlqraGATSESRP-QTADQHSTHRMRte 254
Cdd:cd15384   155 G-----FYTAEWQEQLYNMLSLVFMFPIPLVIMVTCYVLIFITLSKSSRDFQ-----GLEIYTRNrGPNRQRLFHKAK-- 222
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1938531436 255 TKAAKTLCVIMGCFCFCWAPFFVTNIVDPFID-YTVPEKVWTAFLWLGYINSGLNPFLY 312
Cdd:cd15384   223 VKSLRMSAVIVTAFILCWTPYYVIMIWFLFFNpYPLNDILFDVIFFFGMSNSCVNPLIY 281
7tmA_capaR cd15134
neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of ...
21-323 8.88e-21

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; CapaR is a G-protein coupled receptor for the Drosophila melanogaster capa neuropeptides (Drm-capa-1 and -2), which act on the Malpighian tubules to increase fluid transport. The capa peptides are evolutionarily related to vertebrate Neuromedin U neuropeptide and contain a C-terminal FPRXamide motif. CapaR regulates fluid homeostasis through its ligands, thereby acts as a desiccation stress-responsive receptor. CapaR undergoes desensitization, with internalization mediated by beta-arrestin-2.


Pssm-ID: 320262 [Multi-domain]  Cd Length: 298  Bit Score: 91.62  E-value: 8.88e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  21 VLLTFFAMVILMA-ILGNLLVMVAVCRDRQLRKiKTNYFIVSLAFADLLVSVLVMPFGAIELVQ-DIWFYGEMFCLVRTS 98
Cdd:cd15134     1 IPITIIYGIIFVTgVVGNLCTCIVIARNRSMHT-ATNYYLFSLAVSDLLLLILGLPFELYTIWQqYPWVFGEVFCKLRAF 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  99 LDVLLTTASIFHLCCISLDRYYAIcCQPLvYRNKMTPL-RIALMLGGCWVIPmFISFLPimqgwnnIGIVDVIEKRKFNH 177
Cdd:cd15134    80 LSEMSSYASVLTITAFSVERYLAI-CHPL-RSHTMSKLsRAIRIIIAIWIIA-FVCALP-------FAIQTRIVYLEYPP 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 178 NSN-----STFCVFMVNKP-----YAITCSVVaFYIPFLLMVLAYYRIYVTAKEHAqqiqmLQRAGATSESRpqtaDQHS 247
Cdd:cd15134   150 TSGealeeSAFCAMLNEIPpitpvFQLSTFLF-FIIPMIAIIVLYVLIGLQLRRST-----LLRRGQRSVSG----GRRS 219
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 248 THRMRTETkaaKTLCVIMGCFCFCWAPFFVTNIVDPFIDYTvPEKVWTAFLWLGYI-------NSGLNPFLYAFLNKSFR 320
Cdd:cd15134   220 SQSRRTVL---RMLVAVVVAFFICWAPFHAQRLLTVYAKNM-TPPYLFINRILFYIsgvlyyvSSTVNPILYNVMSAKYR 295

                  ...
gi 1938531436 321 RAF 323
Cdd:cd15134   296 QAF 298
7tmA_Vasopressin_Oxytocin cd15196
vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...
27-323 1.16e-20

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320324 [Multi-domain]  Cd Length: 264  Bit Score: 90.37  E-value: 1.16e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  27 AMVILMAILGNLLVMVAVCRDRQlRKIKTNYFIVSLAFADLLVSVLVMpfgaieLVQDIW-----FYGEMF-CLVRTSLD 100
Cdd:cd15196     8 ATILVLALFGNSCVLLVLYRRRR-KLSRMHLFILHLSVADLLVALFNV------LPQLIWdityrFYGGDLlCRLVKYLQ 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 101 VLLTTASIFHLCCISLDRYYAICCqPLVYrNKMTPLRIALMLGGCWVIPMFISfLPimqgwnNIGIVDVIEKRKFNHNSN 180
Cdd:cd15196    81 VVGMYASSYVLVATAIDRYIAICH-PLSS-HRWTSRRVHLMVAIAWVLSLLLS-IP------QLFIFSYQEVGSGVYDCW 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 181 STFCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAkehaqqiqmlqragatsesrpqtadqhsthrMRTETKAAKT 260
Cdd:cd15196   152 ATFEPPWGLRAYITWFTVAVFVVPLIILAFCYGRICYVV-------------------------------WRAKIKTVKL 200
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1938531436 261 LCVIMGCFCFCWAPFFVTNI---VDPFIDYTVPekVWTAFLWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15196   201 TLVVVACYIVCWTPFFVVQMwaaWDPTAPIEGP--AFVIIMLLASLNSCTNPWIYLAFSGNLRRAL 264
7tmA_SKR_NK2R cd16004
substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
26-323 1.28e-20

substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The substance-K receptor (SKR), also known as tachykinin receptor 2 (TACR2) or neurokinin A receptor or NK2R, is a G-protein coupled receptor that specifically binds to neurokinin A. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320670 [Multi-domain]  Cd Length: 285  Bit Score: 90.67  E-value: 1.28e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  26 FAMVILMAILGNLLVMVAVCRDRQLRKIkTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSLDVLLTT 105
Cdd:cd16004     7 YSLIVLVAVTGNATVIWIILAHRRMRTV-TNYFIVNLALADLSMAAFNTAFNFVYASHNDWYFGLEFCRFQNFFPITAMF 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 106 ASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIalMLGGCWVIPMFISFLPIMQGwnnigivdviekrKFNHNSNSTFCv 185
Cdd:cd16004    86 VSIYSMTAIAADRYMAI-IHPFKPRLSAGSTKV--VIAGIWLVALALAFPQCFYS-------------TVTMDQGRTKC- 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 186 fMVNKP----------YAITCSVVAFYIPFLLMVLAYYRIYVTakehaqqiqmLQRAGATSESrpqtADQHSTHRMRTET 255
Cdd:cd16004   149 -IVAWPgdsggkhqltYHLAVIVLIYLLPLAVMFVTYSIIGIT----------LWRSAVPGHQ----AHGAYHRQLQAKK 213
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1938531436 256 KAAKTLCVIMGCFCFCWAPFFVTNIVDPFID----YTVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd16004   214 KFVKTMVVVVVTFAICWLPYHLYFILGSFNEdiycQKYIQQVYLAIFWLAMSSTMYNPIIYCCLNQRFRSGF 285
7tmA_Trissin_R cd15012
trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...
21-322 1.68e-20

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320140 [Multi-domain]  Cd Length: 277  Bit Score: 90.20  E-value: 1.68e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  21 VLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIkTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSLD 100
Cdd:cd15012     1 IFIILYTLVFCCCFFGNLLVILVVTSHRRMRTI-TNFFLANLAVADLCVGIFCVLQNLSIYLIPSWPFGEVLCRMYQFVH 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 101 VLLTTASIFHLCCISLDRYYAICcQPLVYRNKMTPLRIALMLGGCWVIP--MFISFLPIMQGWNNIGIVDVIEKRKFnhn 178
Cdd:cd15012    80 SLSYTASIGILVVISVERYIAIL-HPLRCKQLLTAARLRVTIVTVWLTSavYNTPYFVFSQTVEILVTQDGQEEEIC--- 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 179 snSTFCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVtakehaqqiqMLQRAGATSESRpqtadqhsthrmrtetKAA 258
Cdd:cd15012   156 --VLDREMFNSKLYDTINFIVWYLIPLLIMTVLYSKISI----------VLWKSSSIEARR----------------KVV 207
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1938531436 259 KTLCVIMGCFCFCWAPFFVTNIVDPFIDYTVPEKVWTAFL-----WLGYINSGLNPFLYAFLNKSFRRA 322
Cdd:cd15012   208 RLLVAVVVSFALCNLPYHARKMWQYWSEPYRCDSNWNALLtpltfLVLYFNSAVNPLLYAFLSKRFRQS 276
7tmA_SSTR5 cd15974
somatostatin receptor type 5, member of the class A family of seven-transmembrane G ...
20-323 1.99e-20

somatostatin receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR5 is coupled to inward rectifying K channels and phospholipase C, and plays critical roles in growth hormone and insulin secretion. SSTR5 acts as a negative regulator of PDX-1 (pancreatic and duodenal homeobox-1) expression, which is a conserved homeodomain-containing beta cell-specific transcription factor essentially involved in pancreatic development, among many other functions.


Pssm-ID: 320640 [Multi-domain]  Cd Length: 277  Bit Score: 90.25  E-value: 1.99e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIkTNYFIVSLAFADLLVsVLVMPFGAIELVQDIWFYGEMFCLVRTSL 99
Cdd:cd15974     1 VLIPVIYLLVCAIGLSGNTLVIYVVLRYAKMKTV-TNIYILNLAVADELF-MLGLPFLATQNAISYWPFGSFLCRLVMTV 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 100 DVLLTTASIFHLCCISLDRYYAICcQPLVYRNKMTPLRIALMLGGCWVIPMFISfLPIMqgwnnigIVDVIEKRKFNHNS 179
Cdd:cd15974    79 DGVNQFTSIFCLTVMSIDRYLAVV-HPIKSTKWRRPRVAKLINATVWTLSFLVV-LPVI-------IFSDVQPDLNTCNI 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 180 NSTFCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAQqiqmlqRAGatsesrpqtadqhSTHRMRTETKAAK 259
Cdd:cd15974   150 SWPEPVSVWSTAFIIYTAVLGFFGPLLVICLCYLLIVIKVKSSGL------RVG-------------STKRRKSERKVTR 210
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1938531436 260 TLCVIMGCFCFCWAPFFVTNIVDpfIDYTVPEK-----VWTAFLWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15974   211 MVVIIVVVFVFCWLPFYMLNIVN--LIVILPEEpafvgVYFFVVVLSYANSCANPILYGFLSDNFKQSF 277
7tmA_SSTR cd15093
somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
20-323 2.18e-20

somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. They share common signaling cascades such as inhibition of adenylyl cyclase, activation of phosphotyrosine phosphatase activity, and G-protein-dependent regulation of MAPKs.


Pssm-ID: 320221 [Multi-domain]  Cd Length: 280  Bit Score: 90.21  E-value: 2.18e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIkTNYFIVSLAFADLLVsVLVMPFGAIELVQDIWFYGEMFCLVRTSL 99
Cdd:cd15093     1 VLIPCIYAVVCLVGLCGNSLVIYVVLRYAKMKTV-TNIYILNLAIADELF-MLGLPFLAASNALRHWPFGSVLCRLVLSV 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 100 DVLLTTASIFHLCCISLDRYYAICcQPLVYRNKMTPlRIALMLGGCWVIPMFISFLPIMqgwnnigivdVIEKRKFNHNS 179
Cdd:cd15093    79 DGINMFTSIFCLTVMSVDRYLAVV-HPIKSARWRRP-RVAKVVNLAVWVASLLVILPVV----------VFAGTRENQDG 146
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 180 NSTfCVFMVNKPYA-------ITCSVVAFYIPFLLMVLAYYRIYVTAKEHAQqiqmlqRAGatsesrpqtadqhSTHRMR 252
Cdd:cd15093   147 SSA-CNMQWPEPAAawsagfiIYTFVLGFLLPLLIICLCYLLIVIKVKSAGL------RAG-------------WQQRKR 206
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1938531436 253 TETKAAKTLCVIMGCFCFCWAPFFVTNIVDPFIDYTVPEKVWTAF---LWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15093   207 SERKVTRMVVMVVVVFVICWLPFYVLQLVNVFVQLPETPALVGVYhfvVILSYANSCANPILYGFLSDNFKKSF 280
7tmA_PrRP_R cd15394
prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
26-320 3.01e-20

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prolactin-releasing peptide (PrRP) receptor (previously known as GPR10) is expressed in the central nervous system with the highest levels located in the anterior pituitary and is activated by its endogenous ligand PrRP, a neuropeptide possessing a C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acids (PrRP-20) and the other consists of 31 amino acids (PrRP-31), where PrRP-20 is a C-terminal fragment of PrRP-31. Binding of PrRP to the receptor coupled to G(i/o) proteins activates the extracellular signal-related kinase (ERK) and it can also couple to G(q) protein leading to an increase in intracellular calcium and activation of c-Jun N-terminal protein kinase (JNK). The PrRP receptor shares significant sequence homology with the neuropeptide Y (NPY) receptor, and micromolar levels of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors. PrRP has been shown to reduce food intake and body weight and modify body temperature when administered in rats. It also has been shown to decrease circulating growth hormone levels by activating somatostatin-secreting neurons in the hypothalamic periventricular nucleus.


Pssm-ID: 320516 [Multi-domain]  Cd Length: 286  Bit Score: 89.80  E-value: 3.01e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  26 FAMVILMAILGNLLVMVAVCRDRQLRKIkTNYFIVSLAFADLLVSVLVMPFG-AIELVQDIWFYGEMFCLVRTSLDVLLT 104
Cdd:cd15394     7 YSLVVLVGVVGNYLLIYVICRTKKMHNV-TNFLIGNLAFSDMLMCATCVPLTlAYAFEPRGWVFGRFMCYFVFLMQPVTV 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 105 TASIFHLCCISLDRYYAIcCQPLvyRNKMTPLRIALMLGGCWVIPMFISfLPIMQgwnNIGIVDVIEkrkFNHNSNSTFC 184
Cdd:cd15394    86 YVSVFTLTAIAVDRYYVT-VYPL--RRRISRRTCAYIVAAIWLLSCGLA-LPAAA---HTYYVEFKG---LDFSICEEFW 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 185 VFMVNKPYAITCS--VVAFYIPFLLMVLAYYRIYVTAKEHAQQIQMLQRagatsesrpqTADQHSTHRMRTetkaAKTLC 262
Cdd:cd15394   156 FGQEKQRLAYACStlLITYVLPLLAISLSYLRISVKLRNRVVPGSMTQS----------QAEWDRARRRKT----FRLLV 221
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1938531436 263 VIMGCFCFCWAPFFVTNI---VDP-FIDYTVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFR 320
Cdd:cd15394   222 VVVVAFAICWLPLHIFNVirdIDIdLIDKQYFNLIQLLCHWLAMSSACYNPFLYAWLHDSFR 283
7tmA_SSTR1 cd15970
somatostatin receptor type 1, member of the class A family of seven-transmembrane G ...
21-323 4.34e-20

somatostatin receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR1 is coupled to a Na/H exchanger, voltage-dependent calcium channels, and AMPA/kainate glutamate channels. SSTR1 is expressed in the normal human pituitary and in nearly half of all pituitary adenoma subtypes.


Pssm-ID: 320636 [Multi-domain]  Cd Length: 276  Bit Score: 89.20  E-value: 4.34e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  21 VLLTF-FAMVILMAILGNLLVMVAVCRDRQLrKIKTNYFIVSLAFADLLVsVLVMPFGAIELVQDIWFYGEMFCLVRTSL 99
Cdd:cd15970     1 ILISFiYSVVCLVGLCGNSMVIYVILRYAKM-KTATNIYILNLAIADELL-MLSVPFLVTSTLLRHWPFGSLLCRLVLSV 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 100 DVLLTTASIFHLCCISLDRYYAICcQPLVYRNKMTPLRIALMLGGCWVIPMFIsFLPImqgwnnigivdVIEKRKFNHNS 179
Cdd:cd15970    79 DAINMFTSIYCLTVLSIDRYIAVV-HPIKAARYRRPTVAKMVNLGVWVFSILV-ILPI-----------IIFSNTAPNSD 145
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 180 NSTFCVFMVNKP---YAITCSVVAFYIPFLLMVLAYYRIYVTakehaqqIQMLQRAGATSESRPQtadqhsthRMRTETK 256
Cdd:cd15970   146 GSVACNMQMPEPsqrWLAVFVVYTFLMGFLLPVIAICLCYIL-------IIVKMRVVALKAGWQQ--------RKRSERK 210
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 257 AAKTLCVIMGCFCFCWAPFFVTNIVDPFI---DYTVPEKVwtafLWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15970   211 ITLMVMMVVTVFVICWMPFYVVQLVSVFVgqhDATVSQLS----VILGYANSCANPILYGFLSDNFKRSF 276
7tmA_SREB-like cd15005
super conserved receptor expressed in brain and related proteins, member of the class A family ...
20-323 4.83e-20

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320134 [Multi-domain]  Cd Length: 329  Bit Score: 89.82  E-value: 4.83e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKiKTNYFIVSLAFADLLVSVLVMPFGAIELVQDI-WFYGEMFCLVRTS 98
Cdd:cd15005     1 ALKLTTLGLILCVSLAGNLLFSVLIVRDRSLHR-APYYFLLDLCLADGLRSLACFPFVMASVRHGSgWIYGALSCKVIAF 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  99 LDVLLTTASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMQGWNNIGIVD----VIEKRK 174
Cdd:cd15005    80 LAVLFCFHSAFTLFCIAVTRYMAI-AHHRFYAKRMTFWTCLAVICMAWTLSVAMAFPPVFDVGTYTFIREedqcTFEHRS 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 175 FNHNSNSTFCVFMVnkpyAITCSVVAFYIPFLLMVLAYYRI----YVTAKEH-------------------------AQQ 225
Cdd:cd15005   159 YKANDTLGFMLVLA----VVIAATHLVYLKLLIFLRHHRKMkpaqLVPAISQnwtfhgpgatgqaaanwtagfgrgpTPP 234
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 226 IQMLQRAGATSESRpqtaDQHSTHRMRTETKAAKTLCVIMGCFCFCWAPFFVTNIVDPFID-YTVPEKVWTAFLWLGYIN 304
Cdd:cd15005   235 TLLGIRQAFHSGAR----RLLVLDEFKMEKRLTRMFYAITLLFLLLWSPYIVACYIRVFVRgYAVPQGFLTAAVWMTFAQ 310
                         330
                  ....*....|....*....
gi 1938531436 305 SGLNPFLYAFLNKSFRRAF 323
Cdd:cd15005   311 AGVNPIVCFFFNRELRKCL 329
7tm_GPCRs cd14964
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
33-316 5.40e-20

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410628 [Multi-domain]  Cd Length: 267  Bit Score: 88.64  E-value: 5.40e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  33 AILGNLLVMVAVCRDRQLRKIkTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSLDVLLTTASIFHLC 112
Cdd:cd14964    12 GLLGNLLVLLSLVRLRKRPRS-TRLLLASLAACDLLASLVVLVLFFLLGLTEASSRPQALCYLIYLLWYGANLASIWTTL 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 113 CISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMqGWNNIGIvdviekrkfNHNSNSTFCVFMVNKPY 192
Cdd:cd14964    91 VLTYHRYFAL-CGPLKYTRLSSPGKTRVIILGCWGVSLLLSIPPLV-GKGAIPR---------YNTLTGSCYLICTTIYL 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 193 AITCSVVAFYIPFLLMVLAYYRIyvtAKEHAQQIQMLQRAGatsesrpqtadqhsTHRMRTETKAAKTLCVIMGCFCFCW 272
Cdd:cd14964   160 TWGFLLVSFLLPLVAFLVIFSRI---VLRLRRRVRAIRSAA--------------SLNTDKNLKATKSLLILVITFLLCW 222
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1938531436 273 APFFVTNIVD--PFIDYTVPEKVWTAFlWLGYINSGLNPFLYAFLN 316
Cdd:cd14964   223 LPFSIVFILHalVAAGQGLNLLSILAN-LLAVLASTLNPFIYCLGN 267
7tmA_CXCR1_2 cd15178
CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G ...
20-323 6.02e-20

CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR1 and CXCR2 are closely related chemotactic receptors for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. Expression of CXCR1 and CXCR2 is strictly controlled in neutrophils by external stimuli such as lipopolysaccharide (LPS), tumor necrosis factor (TNF)-alpha, Toll-like receptor agonists, and nitric oxide. CXCL8 (formerly known as interleukin-8) binds with high-affinity and activates both receptors. CXCR1 also binds CXCL7 (neutrophil-activating protein-2), whereas CXCR2 non-selectively binds to all seven ELR-positive chemokines (CXCL1-7). Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341333 [Multi-domain]  Cd Length: 279  Bit Score: 88.87  E-value: 6.02e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIkTNYFIVSLAFADLLVSvLVMPFGAIELVQDiWFYGEMFCLVRTSL 99
Cdd:cd15178     1 LALCVIYVLVFLLSLPGNSLVVLVILYNRRSRSS-TDVYLLHLAIADLLFA-LTLPFWAVSVVKG-WIFGTFMCKLVSLL 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 100 DVLLTTASIFHLCCISLDRYYAIccqplVYRNKMTPLR---IALMLGGCWVIPMFISfLPIMqgwnnigivdVIEKRKFN 176
Cdd:cd15178    78 QEANFYSGILLLACISVDRYLAI-----VHATRALTQKrhlVKFVCAGVWLLSLLLS-LPAL----------LNRDAFKP 141
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 177 HNSNSTFCVFMVNKPYA--------ITCSVVAFYIPFLLMVLAYyriyvtakehaqqiqmlqraGATSESRPQTadqhst 248
Cdd:cd15178   142 PNSGRTVCYENLGNESAdkwrvvlrILRHTLGFLLPLVVMLFCY--------------------GFTIKTLLQT------ 195
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 249 hRMRTETKAAKTLCVIMGCFCFCWAPFFVTNIVDPF-----IDYTVP--EKVWTAFLW---LGYINSGLNPFLYAFLNKS 318
Cdd:cd15178   196 -RSFQKHRAMRVIFAVVLAFLLCWLPYNVTVLIDTLmrtklITETCElrNHVDVALYVtqiLGFLHSCINPVLYAFIGQK 274

                  ....*
gi 1938531436 319 FRRAF 323
Cdd:cd15178   275 FRNNL 279
7tmA_BRS-3 cd15123
bombesin receptor subtype 3, member of the class A family of seven-transmembrane G ...
26-323 1.09e-19

bombesin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; BRS-3 is classified as an orphan receptor and belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and gastrin-releasing peptide receptor (GRPR). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple primarily to the G proteins of G(q/11) family. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. BRS-3 is suggested to play a role in sperm cell division and maturation.


Pssm-ID: 320251 [Multi-domain]  Cd Length: 294  Bit Score: 88.44  E-value: 1.09e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  26 FAMVILMAILGNLLVMVAVCRDRQLRKIKtNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSLDVLLTT 105
Cdd:cd15123     7 YAVIISVGILGNAILIKVFFKIKSMQTVP-NIFITSLAFGDLLLLLTCVPVDATRYIADTWLFGRIGCKLLSFIQLTSVG 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 106 ASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMqgwnnigIVDVIEKRKFNHNSNSTFCV 185
Cdd:cd15123    86 VSVFTLTVLSADRYRAI-VKPLELQTSDAVLKTCCKAGCVWIVSMLFAIPEAV-------FSDLYSFRDPEKNTTFEACA 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 186 ------FMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAQQIqmlqragatsesrPQTADQHSTHRMRTETKAAK 259
Cdd:cd15123   158 pypvseKILQEIHSLLCFLVFYIIPLSIISVYYFLIARTLYKSTFNM-------------PAEEHSHARKQIESRKRVAK 224
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 260 TLCVIMGCFCFCWAPFFVTNIVDPF-----IDYTVPEKVWTAF-LWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15123   225 TVLVLVALFAFCWLPNHILYLYRSFtyhtsVDSSAFHLIATIFsRVLAFSNSCVNPFALYWLSKSFRQHF 294
7tmA_GPR3_GPR6_GPR12-like cd15100
G protein-coupled receptors 3, 6, 12, and related proteins, member of the class A family of ...
59-322 1.43e-19

G protein-coupled receptors 3, 6, 12, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3. Also included in this subfamily is GPRx, also known as GPR185, which involved in the maintenance of meiotic arrest in frog oocytes.


Pssm-ID: 320228 [Multi-domain]  Cd Length: 268  Bit Score: 87.53  E-value: 1.43e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  59 IVSLAFADLLVSV-LVMPFGAIELVqdiwfYGEMFCLVRTSLDVLLTTASIFHLCCISLDRYYAICcQPLVYRNKMTPLR 137
Cdd:cd15100    39 IGSLALADLLAGLgLILHFVFRYCV-----YSEALSLVSVGLLVAAFSASVCSLLAITVDRYLSLY-NALTYYSERTLTF 112
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 138 IALMLGGCWVIPMFISFLPIMqGWNNIgivdviekrkfnHNSNSTFCVFMVNKPYAITCSVvAFYIPFLLMVLAYYRIYV 217
Cdd:cd15100   113 TYVMLALLWTLALGLGLLPVL-GWNCL------------REGSSCSVVRPLTKNHLAVLAV-AFLLVFALMLQLYAQICR 178
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 218 TAKEHAQQIQMLQRAGATSesrpqtadqhstHRMRTEtKAAKTLCVIMGCFCFCWAPFFVTNIVDpfiDYTVPEKVWTAF 297
Cdd:cd15100   179 IVLRHAHQIALQRHFLAPS------------HYVATR-KGVSTLALILGTFAACWIPFAVYCLLG---DGSSPALYTYAT 242
                         250       260
                  ....*....|....*....|....*
gi 1938531436 298 LWLGYINSGLNPFLYAFLNKSFRRA 322
Cdd:cd15100   243 LLPATYNSMINPIIYAFRNQDIQKV 267
7tmA_GPR26_GPR78-like cd15219
G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G ...
21-321 1.48e-19

G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G protein-coupled receptors; Orphan G-protein coupled receptor 26 (GPR26) and GPR78 are constitutively active and coupled to increased cAMP formation. They are closely related based on sequence homology and comprise a conserved subgroup within the class A G-protein coupled receptor (GPCR) superfamily. Both receptors are widely expressed in selected tissues of the brain but their endogenous ligands are unknown. GPR26 knockout mice showed increased levels of anxiety- and depression-like behaviors, whereas GPR78 has been implicated in susceptibility to bipolar affective disorder and schizophrenia. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320347 [Multi-domain]  Cd Length: 264  Bit Score: 87.51  E-value: 1.48e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  21 VLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSLD 100
Cdd:cd15219     1 LLAVLLVVVLVVSLLSNLLVLLCFLYSAELRKQVPGIFLLNLSFCNLLLTVLNMPFTLLGVVRNRQPFGDGFCQAVGFLE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 101 VLLTTASIFHLCCISLDRYYAICCqPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMQGWN---------NIGIVDVIE 171
Cdd:cd15219    81 TFLTSNAMLSMAALSIDRWIAVVF-PLSYTSKMRYRDAALMVGYSWLHSLTFSLVALFLSWLgysslyascTLHLPREEE 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 172 KRKFnhnsnstfcvfmvnKPYAITCSVVAFYIPFLLMVLAYYRIyvtakehaqqiqmlqragatsesrpqtadqhstHRM 251
Cdd:cd15219   160 RRRF--------------AVFTAFFHAFTFLLSLLVLCVTYLKV---------------------------------LKV 192
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 252 RTETKAAKTLCVIMGCFCFCWAPFFVTNIVDPFIDYTVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRR 321
Cdd:cd15219   193 RRRQRATKKISIFIGTFVLCFAPYVITRLVELLPFVTINRYWGIVSKCLTYSKAASDPFVYSLLRQQYRK 262
7tmA_C3aR cd15115
complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of ...
20-320 2.07e-19

complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320243 [Multi-domain]  Cd Length: 265  Bit Score: 87.13  E-value: 2.07e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVmVAVCRDRQLRKIKTNYFiVSLAFADLLVsVLVMPFG-AIELVQDIWFYGEMFCLVRTS 98
Cdd:cd15115     1 ILSLVVLSLTFLLGVPGNGLV-IWVAGLKMKRTVNTIWF-LNLAVADLLC-CLSLPFSiAHLLLNGHWPYGRFLCKLLPS 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  99 LDVLLTTASIFHLCCISLDRYyAICCQPLVYRNKMTPLRIALMLGGCWVIPMFISfLPIMQgwnnigivdvieKRKFNHN 178
Cdd:cd15115    78 IIVLNMFASVFTLTAISLDRF-LLVIKPVWAQNHRSVLLACLLCGCIWILALLLC-LPVFI------------YRTTVTD 143
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 179 SNSTFCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIyvtakehaqqiqmLQRAGATSESRPQTadqhsthrmrtetKAA 258
Cdd:cd15115   144 GNHTRCGYDFLVAITITRAVFGFLLPLLIIAACYSFI-------------AFRMQRGRFAKSQS-------------KTF 197
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1938531436 259 KTLCVIMGCFCFCWAPFFVTNIVdpfIDYTVPEKVWTAFLW------LGYINSGLNPFLYAFLNKSFR 320
Cdd:cd15115   198 RVIIAVVVAFFVCWAPYHIIGIL---SLYGDPPLSKVLMSWdhlsiaLAYANSCLNPVLYVFMGKDFK 262
7tmA_SSTR4 cd15973
somatostatin receptor type 4, member of the class A family of seven-transmembrane G ...
20-323 2.42e-19

somatostatin receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR4 plays a critical role in mediating inflammation. Unlike other SSTRs, SSTR4 subtype is not detected in all pituitary adenomas while it is expressed in the normal human pituitary.


Pssm-ID: 320639 [Multi-domain]  Cd Length: 274  Bit Score: 86.83  E-value: 2.42e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLrKIKTNYFIVSLAFADLLVsVLVMPFGAIELVQDIWFYGEMFCLVRTSL 99
Cdd:cd15973     1 VVIQFIYALVCLVGLIGNSMVIFVILRYAKM-KTATNIYILNLAIADELF-MLSVPFLAASAALQHWPFGSAMCRTVLSV 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 100 DVLLTTASIFHLCCISLDRYYAICcQPLVYRNKMTPlRIALMLGGC-WVIPMF-ISFLPIMQGWNNIGIVDVIEKRKFNH 177
Cdd:cd15973    79 DGINMFTSVFCLTVLSVDRYIAVV-HPLRAARYRRP-TVAKMINICvWILSLLvISPIIIFADTATRKGQAVACNLIWPH 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 178 NSNSTfcvfmvnkPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAQQIQMLQRAgatsesrpqtadqhsthrmRTETKA 257
Cdd:cd15973   157 PAWSA--------AFVIYTFLLGFLLPVLAIGLCYILIIGKMRAVALKAGWQQRR-------------------KSEKKI 209
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1938531436 258 AKTLCVIMGCFCFCWAPFFVTNIVDPFIdYTVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15973   210 TRMVLMVVTVFVICWMPFYVVQLLNLFL-PRLDATVNHASLILSYANSCANPILYGFLSDNFRRSF 274
7tmA_prokineticin-R cd15204
prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
20-323 2.79e-19

prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Prokineticins 1 (PROK1) and 2 (PROK2), also known as endocrine gland vascular endothelial factor and Bombina varigata 8, respectively, are multifunctional chemokine-like peptides that are highly conserved across species. Prokineticins can bind with similar affinities to two closely homologous 7-transmembrane G protein coupled receptors, PROKR1 and PROKR2, which are phylogenetically related to the tachykinin receptors. Prokineticins and their GPCRs are widely distributed in human tissues and are involved in numerous physiological roles, including gastrointestinal motility, generation of circadian rhythms, neuron migration and survival, pain sensation, angiogenesis, inflammation, and reproduction. Moreover, different point mutations in genes encoding PROK2 or its receptor (PROKR2) can lead to Kallmann syndrome, a disease characterized by delayed or absent puberty and impaired olfactory function.


Pssm-ID: 320332 [Multi-domain]  Cd Length: 288  Bit Score: 86.95  E-value: 2.79e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIkTNYFIVSLAFADLLVSVLVMPFGAIELV--QDIWFYGEMFCLV-- 95
Cdd:cd15204     1 IVLGVVYVLIMLVCGVGNLLLIAVLARYKKLRTL-TNLLIANLALSDFLVAVFCLPFEMDYYVvrQRSWTHGDVLCAVvn 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  96 --RT-SLDVllttaSIFHLCCISLDRYYAICCQPlvyRNKMTPLRIALMLGGCWVIPMFISfLPimqgwnnigiVDVIEK 172
Cdd:cd15204    80 ylRTvSLYV-----STNALLVIAIDRYLVIVHPL---KPRMKRRTACVVIALVWVVSLLLA-IP----------SAVYSK 140
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 173 RKFNHNSNSTFC-------VFMVNKPYAITCSVVAFYIPFLLMVLAYYRIyvtakehAQQIQMLQRAGATSESRPQtadq 245
Cdd:cd15204   141 TTPYANQGKIFCgqiwpvdQQAYYKAYYLFLFVLEFVLPVLIMTLCYLRI-------VRKVWFRRVPGQQTEQIRR---- 209
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 246 hsthRMRTETKAAKTLCVIMGCFCFCWAPFFVTNIV-DPFIDYTVPEKVWTAFLW----LGYINSGLNPFLYAFLNKSFR 320
Cdd:cd15204   210 ----RLRRRRRKVRLLVVILTAFVLCWAPYYGYAIVrDFFPTLLSKEKLNTTIFYiveaLAMSNSMINTVVYVAFNNNIR 285

                  ...
gi 1938531436 321 RAF 323
Cdd:cd15204   286 KYL 288
7tmA_CXCR3 cd15180
CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
20-323 2.96e-19

CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR3 is an inflammatory chemotactic receptor for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. CXCR3 specifically binds three chemokines CXCL9 (monokine induced by gamma-interferon), CXCL10 (interferon induced protein of 10 kDa), and CXCL11 (interferon inducible T-cell alpha-chemoattractant, I-TAC). CXC3R is expressed on CD4+ Th1 and CD8+ cytotoxic T lymphocytes as well as highly on innate lymphocytes, such as NK cells and NK T cells, where it may mediate the recruitment of these cells to the sites of infection and inflammation. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341335 [Multi-domain]  Cd Length: 280  Bit Score: 86.67  E-value: 2.96e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMvAVCRDRQLRKIKTNYFIVSLAFADLLVsVLVMPFGAIELVQDiWFYGEMFCLVRTSL 99
Cdd:cd15180     1 VFLPVLYSLVFLLGLLGNGLVL-AVLLQKRRNLSVTDTFILHLALADILL-LVTLPFWAVQAVHG-WIFGTGLCKLAGAV 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 100 DVLLTTASIFHLCCISLDRYYAIccqplVYRNKMTPLRIALMLGGCWVIPMFISFLPIMQGWnnigivdVIEKRKFNHNS 179
Cdd:cd15180    78 FKINFYCGIFLLACISFDRYLSI-----VHAVQMYSRKKPMLVHLSCLIVWLFCLLLSIPDF-------IFLEATKDPRQ 145
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 180 NSTFCV--FMVNKPYAITCS-----VVAFYIPFLLMVLAYYRIYVTAKEHAQQIQMLqragatsesrpqtadqhsthrmr 252
Cdd:cd15180   146 NKTECVhnFPQSDTYWWLALrllyhIVGFLLPLAVMVYCYTSILLRLLRSSQGFQKQ----------------------- 202
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 253 tetKAAKTLCVIMGCFCFCWAPFFVTNIVDPFIDYTVPEK-------VWTAFL---WLGYINSGLNPFLYAFLNKSFRRA 322
Cdd:cd15180   203 ---RAIRVIVAVVVVFFLCWTPYNIALLVDTLIDLSVLDRncgtesrLDIALSvtsSLGYFHCCLNPLLYAFVGVKFRRK 279

                  .
gi 1938531436 323 F 323
Cdd:cd15180   280 L 280
7tmA_UII-R cd14999
urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled ...
24-320 3.20e-19

urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The urotensin-II receptor (UII-R, also known as the hypocretin receptor) is a member of the class A rhodopsin-like G-protein coupled receptors, which binds the peptide hormone urotensin-II. Urotensin II (UII) is a vasoactive somatostatin-like or cortistatin-like peptide hormone. However, despite the apparent structural similarity to these peptide hormones, they are not homologous to UII. Urotensin II was first identified in fish spinal cord, but later found in humans and other mammals. In fish, UII is secreted at the back part of the spinal cord, in a neurosecretory centre called uroneurapophysa, and is involved in the regulation of the renal and cardiovascular systems. In mammals, urotensin II is the most potent mammalian vasoconstrictor identified to date and causes contraction of arterial blood vessels, including the thoracic aorta. The urotensin II receptor is a rhodopsin-like G-protein coupled receptor, which binds urotensin-II. The receptor was previously known as GPR14, or sensory epithelial neuropeptide-like receptor (SENR). The UII receptor is expressed in the CNS (cerebellum and spinal cord), skeletal muscle, pancreas, heart, endothelium and vascular smooth muscle. It is involved in the pathophysiological control of cardiovascular function and may also influence CNS and endocrine functions. Binding of urotensin II to the receptor leads to activation of phospholipase C, through coupling to G(q/11) family proteins. The resulting increase in intracellular calcium may cause the contraction of vascular smooth muscle.


Pssm-ID: 320130 [Multi-domain]  Cd Length: 282  Bit Score: 86.73  E-value: 3.20e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  24 TFFAMVILMAILGNLLVMVAVCRDRQLRKIKTNYfIVSLAFADLLVsVLVMPFGAIELVQDIWFYGEMFCLVRTSLDVLL 103
Cdd:cd14999     4 TVLSLMCVVGVAGNVYTLVVMCLSMRPRASMYVY-ILNLALADLLY-LLTIPFYVSTYFLKKWYFGDVGCRLLFSLDFLT 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 104 TTASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMlGGCWVIPMFISfLPIMqgwnnigiVDVIEKRKFNHNSNSTF 183
Cdd:cd14999    82 MHASIFTLTVMSTERYLAV-VKPLDTVKRSKSYRKLLA-GVIWLLSLLLT-LPMA--------IMIRLVTVEDKSGGSKR 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 184 CVF-----MVNKPYAITCSVVAFYIPFLLMVLAYYRIyvtakehaqqiqmlqragATSESRPQTADQHSTHRMRTETKAA 258
Cdd:cd14999   151 ICLptwseESYKVYLTLLFSTSIVIPGLVIGYLYIRL------------------ARKYWLSQAAASNSSRKRLPKQKVL 212
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1938531436 259 KTLCVIMGCFCFCWAPFFVTNIVDPFIDYTVPEKVWTAFLW-----LGYINSGLNPFLYAFLNKSFR 320
Cdd:cd14999   213 KMIFTIVLVFWACFLPFWIWQLLYLYSPSLSLSPRTTTYVNylltcLTYSNSCINPFLYTLLTKNYK 279
7tmA_CCK-AR cd15978
cholecystokinin receptor type A, member of the class A family of seven-transmembrane G ...
21-323 3.85e-19

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320644 [Multi-domain]  Cd Length: 278  Bit Score: 86.46  E-value: 3.85e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  21 VLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIkTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSLD 100
Cdd:cd15978     2 VRILLYSLIFLLSVLGNSLIIAVLIRNKRMRTV-TNIFLLSLAVSDLMLCLFCMPFTLIPNLLKDFIFGSAVCKTATYFM 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 101 VLLTTASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVIPmFISFLPIMQGWNNIGIVDviekrkfNHNSN 180
Cdd:cd15978    81 GISVSVSTFNLVAISLERYSAI-CKPLKSRVWQTKSHALKVIAATWCLS-FTIMLPYPIYSNLVPFTR-------INNST 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 181 STFCVFM-----VNKPYAITCSVVAFYIPFLLMVLAYYRIYVtakEHAQQIQMLQragatsesrpqtadqhsthrmrTET 255
Cdd:cd15978   152 GNMCRLLwpndvTQQSWYIFLLLILFLIPGIVMMTAYGLISL---ELYRGIKFLM----------------------AKK 206
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1938531436 256 KAAKTLCVIMGCFCFCWAPFFVTNIVDPFiDYTVPEKVWTA-----FLWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15978   207 RVIRMLIVIVILFFLCWTPIFSANAWRAF-DTRSADRLLSGapisfIHLLSYTSACVNPIIYCFMNKRFRMGF 278
7tmA_CCK-BR cd15979
cholecystokinin receptor type B, member of the class A family of seven-transmembrane G ...
21-323 3.85e-19

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320645 [Multi-domain]  Cd Length: 275  Bit Score: 86.41  E-value: 3.85e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  21 VLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIkTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSLD 100
Cdd:cd15979     2 VRILLYSVIFLLSVFGNMLIIVVLGLNKRLRTV-TNSFLLSLALSDLMLAVFCMPFTLIPNLMGTFIFGEVICKAVAYLM 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 101 VLLTTASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVIPmFISFLPIMQgWNNIGIVDViEKRKFNHNSN 180
Cdd:cd15979    81 GVSVSVSTFSLVAIAIERYSAI-CNPLQSRVWQTRSHAYRVIAATWLLS-GLIMIPYPV-YSVTVPVPV-GDRPRGHQCR 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 181 STFCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIyvtAKEhaqqiqmLQRAgatsesrpqtadqhsthrMRTETKAAKT 260
Cdd:cd15979   157 HAWPSAQVRQAWYVLLLLILFFIPGVVMIVAYGLI---SRE-------LYRG------------------LLAKKRVIRM 208
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1938531436 261 LCVIMGCFCFCWAPFFVTNIVDPFIDYTVPEKVWTAFL----WLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15979   209 LVVIVAMFFLCWLPIFSANTWRAFDPLSAHRALSGAPIsfihLLSYTSACVNPLVYCFMNRRFRKAF 275
7tmA_NKR_NK3R cd16003
neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
26-323 3.96e-19

neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin-K receptor (NKR), also known as tachykinin receptor 3 (TACR3) or neurokinin B receptor or NK3R, is a G-protein coupled receptor that specifically binds to neurokinin B. The tachykinins (TKs) act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320669 [Multi-domain]  Cd Length: 282  Bit Score: 86.52  E-value: 3.96e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  26 FAMVILMAILGNLLVMVAVCRDRQLRKIkTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSLDVLLTT 105
Cdd:cd16003     7 YGFVVAVAVFGNLIVIWIILAHKRMRTV-TNYFLVNLAFSDASMAAFNTLINFIYALHSEWYFGEAYCRFHNFFPITSVF 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 106 ASIFHLCCISLDRYYAICcQPLVYRNKMTPLRIalMLGGCWVIPMFISFLPIMqgwnnIGIVDVIEKRkfnhnsnsTFCv 185
Cdd:cd16003    86 ASIYSMTAIAVDRYMAII-DPLKPRLSATATKV--VIGSIWILAFLLAFPQCL-----YSKTKVMPGR--------TLC- 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 186 fMVNKP--------YAITCSVVAFYIPFLLMVLAYYRIYVTAkehaqqiqmlqragATSESRPQTADQHStHRMRTETKA 257
Cdd:cd16003   149 -FVAWPggpdqhftYHIIVIVLVYCLPLLVMGITYTIVGITL--------------WGGEIPGDTSDKYH-EQLRAKRKV 212
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 258 AKTLCVIMGCFCFCWAP----FFVTNIVDPFIDYTVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd16003   213 VKMMIIVVLTFAICWLPyhiyFIVTGLYQQLNRWKYIQQVYLASFWLAMSSTMYNPIIYCCLNKRFRAGF 282
7tmA_Gal2_Gal3_R cd15097
galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G ...
20-323 4.66e-19

galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320225 [Multi-domain]  Cd Length: 279  Bit Score: 86.42  E-value: 4.66e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSL 99
Cdd:cd15097     1 VIVPVVFSLIFLLGTVGNSLVLAVLLRSGQSGHNTTNLFILNLSVADLCFILFCVPFQATIYSLEGWVFGSFLCKAVHFF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 100 DVLLTTASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVIPM-----FISFLPIMQGWNNIGIVDVIEKRK 174
Cdd:cd15097    81 IYLTMYASSFTLAAVSVDRYLAI-RYPLRSRELRTPRNAVAAIALIWGLSLlfagpYLSYYDLIDYANSTVCMPGWEEAR 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 175 FNHNSNSTFcvfmvnkpyaitcsVVAFYIPFLLMVLAYYRiyvtakehaqQIQMLQRA----GATSESRpqtadqhsthr 250
Cdd:cd15097   160 RKAMDTCTF--------------AFGYLIPVLVVSLSYTR----------TIKYLWTAvdplEAMSESK----------- 204
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1938531436 251 mRTETKAAKTLCVIMGCFCFCWAPFFVTNIVDPFIDYTVPEKVWTAFLW---LGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15097   205 -RAKRKVTKMIIIVTALFCLCWLPHHVVILCYLYGDFPFNQATYAFRLLshcMAYANSCLNPIVYALVSKHFRKGF 279
7tmA_GPR161 cd15214
orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G ...
28-321 4.72e-19

orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR161, an orphan GPCR, is a negative regulator of Sonic hedgehog (Shh) signaling, which promotes the processing of zinc finger protein GLI3 into its transcriptional repressor form (GLI3R) during neural tube development. In the absence of Shh, this proteolytic processing is normally mediated by cAMP-dependent protein kinase A (PKA). GPR161 is recruited to primary cilia by a mechanism depends on TULP3 (tubby-related protein 3) and the intraflagellar complex A (IFT-A). Moreover, Gpr161 knockout mice show phenotypes observed in Tulp3/IFT-A mutants, and cause increased Shh signaling in the neural tube. Taken together, GPR161 negatively regulates the PKA-dependent GLI3 processing in the absence of Shh signal by coupling to G(s) protein, which causes activation of adenylate cyclase, elevated cAMP levels, and activation of PKA. Conversely, in the presence of Shh, GPR161 is removed from the cilia by internalization into the endosomal recycling compartment, leading to downregulation of its activity and thereby allowing Shh signaling to proceed. In addition, GPR161 is over-expressed in triple-negative breast cancer (lacking estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (HER2) expression) and correlates with poor prognosis. Mutations of GPR161 have also been implicated as a novel cause for pituitary stalk interruption syndrome (PSIS), a rare congenital disease of the pituitary gland. GPR161 is a member of the class A family of GPCRs, which contains receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320342 [Multi-domain]  Cd Length: 261  Bit Score: 85.76  E-value: 4.72e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  28 MVILMAILGNLLVMVAVCRDRQLRKIkTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSLDVLLTTAS 107
Cdd:cd15214     8 IIAILICLGNLVIVVTLYKKSYLLTL-SNKFVFSLTLSNLLLSVLVLPFVVTSSIRREWIFGVVWCNFSALLYLLISSAS 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 108 IFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVIPMfISFLPIMQGWNNIgivdviekrKFNHNSNSTFCVFM 187
Cdd:cd15214    87 MLTLGAIAIDRYYAV-LYPMVYPMKITGNRAVLALVYIWLHSL-IGCLPPLFGWSSL---------EFDRFKWMCVAAWH 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 188 VNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEhaqqiqmlqragatsesrpqtadqhsthrmrTETKAAKTLCVIMGC 267
Cdd:cd15214   156 KEAGYTAFWQVWCALLPFVVMLVCYGFIFRVARA-------------------------------NQCKAFITILVVLGA 204
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1938531436 268 FCFCWAPFFVTNIVDPFI-DYTVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRR 321
Cdd:cd15214   205 FVTTWGPYMVVISTEALWgKNSVSPQLETLATWLSFTSAVCHPLIYGLWNKTVRK 259
7tmA_GRPR cd15124
gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
20-323 6.12e-19

gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The gastrin-releasing peptide receptor (GRPR) is a G-protein coupled receptor whose endogenous ligand is gastrin releasing peptide. GRP shares high sequence homology with the neuropeptide neuromedin B in the C-terminal region. This receptor is high glycosylated and couples to a pertussis-toxin-insensitive G protein of the family of Gq/11, which leads to the activation of phospholipase C. Gastrin-releasing peptide (GRP) is a potent mitogen for neoplastic tissues and involved in regulating multiple functions of the gastrointestinal and central nervous systems. These include the release of gastrointestinal hormones, the contraction of smooth muscle cells, and the proliferation of epithelial cells. GRPR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320252 [Multi-domain]  Cd Length: 293  Bit Score: 86.11  E-value: 6.12e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIKtNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSL 99
Cdd:cd15124     1 YAIPTVYGIIILIGLIGNITLIKIFCTVKSMRNVP-NLFISSLALGDLLLLVTCAPVDASRYLADEWLFGRVGCKLIPFI 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 100 DVLLTTASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVIPMFISflpimqgwnnigIVDVIEKRKFNHNS 179
Cdd:cd15124    80 QLTSVGVSVFTLTALSADRYKAI-VRPMDIQASNALMKICLKAALIWILSMLLA------------IPEAVFSDLHPFYD 146
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 180 NSTFCVFMVNKPYA----------ITCSVVAFYIPFLLMVLAYYriYVTAKEHAQqiqmlqragaTSESRPQTADQHSTH 249
Cdd:cd15124   147 KSTNKTFVSCAPYPhsnelhpkihSMASFLIFYVIPLSIISVYY--YFIAKNLIR----------SAYNLPVEGNVHVRR 214
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 250 RMRTETKAAKTLCVIMGCFCFCWAPffvTNIVDPFIDYTVPEkVWTAFLW---------LGYINSGLNPFLYAFLNKSFR 320
Cdd:cd15124   215 QIESRKRLAKTVLVFVGLFAFCWLP---NHIIYLYRSYHYSE-VDTSMLHfvssicariLAFTNSCVNPFALYLLSKSFR 290

                  ...
gi 1938531436 321 RAF 323
Cdd:cd15124   291 KQF 293
7tmA_AKHR cd15382
adipokinetic hormone receptor, member of the class A family of seven-transmembrane G ...
20-322 6.39e-19

adipokinetic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flight, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. AKH is structurally related to the mammalian gonadotropin-releasing hormone (GnRH) and they share a common ancestor. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320504 [Multi-domain]  Cd Length: 298  Bit Score: 86.21  E-value: 6.39e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSL 99
Cdd:cd15382     1 LVSIIVYSVLFLIAAVGNLTVLLILLRNRRRKRSRVNILLMHLAIADLLVTFIMMPLEIGWAATVAWLAGDFLCRLMLFF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 100 DVLLTTASIFHLCCISLDRYYAIcCQPLvyRNKMTPLRIALMLGGCWV------IPMFISFL----PIMQGWNNIGIVDV 169
Cdd:cd15382    81 RAFGLYLSSFVLVCISLDRYFAI-LKPL--RLSDARRRGRIMLAVAWVisflcsIPQSFIFHveshPCVTWFSQCVTFNF 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 170 IekrkfnhnsNSTFCVFMvnkpYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAQQIQmLQRAGATSESRPQTADQHSTH 249
Cdd:cd15382   158 F---------PSHDHELA----YNIFNMITMYALPLIIIVFCYSLILCEISRKSKEKK-EDVSEKSSSVRLRRSSVGLLE 223
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1938531436 250 RMRTETkaAKTLCVIMGCFCFCWAPFFVTNIVDpFIDYT----VPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRA 322
Cdd:cd15382   224 RARSRT--LKMTIVIVLVFIICWTPYFIMSLWY-WFDREsaskVDPRIQKGLFLFAVSNSCMNPIVYGYFSIDLRRE 297
7tmA_GPR19 cd15008
G protein-coupled receptor 19, member of the class A family of seven-transmembrane G ...
25-321 7.74e-19

G protein-coupled receptor 19, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 19 is an orphan receptor that is expressed predominantly in neuronal cells during mouse embryogenesis. Its mRNA is found frequently over-expressed in patients with small cell lung cancer. GPR19 shares a significant amino acid sequence identity with the D2 dopamine and neuropeptide Y families of receptors. Human GPR19 gene, intronless in the coding region, also has a distribution in brain overlapping that of the D2 dopamine receptor gene, and is located on chromosome 12. GPR19 is a member of the class A family of GPCRs, which represents a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320137 [Multi-domain]  Cd Length: 275  Bit Score: 85.66  E-value: 7.74e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  25 FFAMVILMAILGNLLVMVAVCRDRQLRKiKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSLDVLLT 104
Cdd:cd15008     5 VFGVLWLVSVFGNSLVCLVIHRSRRTQS-TTNYFVVSMACADLLLSVASAPFVLLQFTSGRWTLGSAMCKLVRYFQYLTP 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 105 TASIFHLCCISLDRYYAIcCQPLVYrnKMTPLRIALMLGGCWVI-PMFISFLPIMQGWNNigivdviekrkfNHNSNSTF 183
Cdd:cd15008    84 GVQIYVLLSICVDRFYTI-VYPLSF--KVSREKAKKMIAASWLFdAAFVSPALFFYGSNW------------GPHCNFFL 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 184 CVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIyvtakehaqqIQMLQRAGATSESRPQTADQHSthrmRTETKAAKTLCV 263
Cdd:cd15008   149 PDSWDGAAYAIIHLLVGFLVPSILIILFYQKV----------IKYIWRIGTDGRTVRRTMNIVP----RTKVKTIKMFLM 214
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1938531436 264 IMGCFCFCWAPFFVTNIVDPF-IDYTVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRR 321
Cdd:cd15008   215 LNSMFLLSWLPFYVVQLWHPReSDYRQSSLVFLAVTWISFSSSASKPTLYSVYNANFRR 273
7tmA_NMU-R cd15133
neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled ...
26-323 7.93e-19

neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320261 [Multi-domain]  Cd Length: 298  Bit Score: 86.04  E-value: 7.93e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  26 FAMVILMAILGNLLVMVAVCRDRQLRKiKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWF-YGEMFCLVRTSLDVLLT 104
Cdd:cd15133     7 YLLIFVVGVVGNVLTCLVIARHKAMRT-PTNYYLFSLAVSDLLVLLLGMPLELYELWQNYPFlLGSGGCYFKTFLFETVC 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 105 TASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVIPMFISfLPimqgwnNIGIVDVIEKRKFNHNSnstfC 184
Cdd:cd15133    86 LASILNVTALSVERYIAV-VHPLAARTCSTRPRVTRVLGCVWGVSMLCA-LP------NTSLHGIKFLGSGVPAS----A 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 185 VFMVNKPYAI------TCSVVAFYIPFLLMVLAYYRIYVTAKEhaQQIQMLQRAGATSESRPQTADQHSthrmRTETKAA 258
Cdd:cd15133   154 QCTVRKPQAIynmipqHTGHLFFVLPMAVISVLYLLMALRLAR--ERGLDATGAGSKIGTRTGQLLQHP----RTRAQVT 227
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1938531436 259 KTLCVIMGCFCFCWAPFFVTNIVDPFIDYtvpekvWTAFL------------WLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15133   228 KMLFILVVVFAICWAPFHIDRLMWSFISD------WTDNLhevfqyvhiisgVFFYLSSAVNPILYNLMSTRFREMF 298
7tmA_S1PR cd15102
sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G ...
25-323 9.77e-19

sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320230 [Multi-domain]  Cd Length: 270  Bit Score: 85.21  E-value: 9.77e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  25 FFAMVILMAILGNLLVMVAVCRDRQLRKiKTNYFIVSLAFADLL------VSVLVMPFGAIELVQDIWFygemfclVRTS 98
Cdd:cd15102     6 VFVAICCFIVLENLLVLIAIWRHMKFHR-PMYYFLGNLALSDLLagaaylANILLSGARTLRLSPAQWF-------LREG 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  99 LDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTplRIALMLGGCWVIPMFISFLPIMqGWNNIGIVDviekrkfnhn 178
Cdd:cd15102    78 SMFVALSASVFSLLAIAIERHLTMAKMKPYGASKTS--RVLLLIGACWLISLLLGGLPIL-GWNCLGALD---------- 144
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 179 SNSTFcVFMVNKPYAITCsVVAFYIPFLLMVLAYYRIYVTAKEHAQQIQmlqRAGATSESRpqtadqhsthrmrtetKAA 258
Cdd:cd15102   145 ACSTV-LPLYSKHYVLFC-VTIFAGILAAIVALYARIYCLVRASGRKAT---RASASPRSL----------------ALL 203
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1938531436 259 KTLCVIMGCFCFCWAPFFVTNIVDpfidytVPEKVWTA--------FLWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15102   204 KTVLIVLLVFIACWGPLFILLLLD------VACPVKTCpilykadwFLALAVLNSALNPIIYTLRSRELRRAV 270
7tmA_GnRHR_vertebrate cd15383
vertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
31-323 1.83e-18

vertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320505 [Multi-domain]  Cd Length: 295  Bit Score: 84.73  E-value: 1.83e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  31 LMAILGNLLVMVAVCRDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSLDVLLTTASIFH 110
Cdd:cd15383    12 VLSACSNLAVLWSATRNRRRKLSHVRILILHLAAADLLVTFVVMPLDAAWNVTVQWYAGDLACRLLMFLKLFAMYSSAFV 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 111 LCCISLDRYYAIcCQPLVY-----RNKMTpLRIALMLGGCWVIPMFISF--LPIMQGWNNIGIVDVIEKRKFNHNSNSTF 183
Cdd:cd15383    92 TVVISLDRHAAI-LNPLAIgsarrRNRIM-LCAAWGLSALLALPQLFLFhtVTATPPVNFTQCATHGSFPAHWQETLYNM 169
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 184 CVFmvnkpyaitcsVVAFYIPFLLMVLAYYRIYVtakehaqQIQMLQRAGATSESRPQTADQHSTHRMRTETKAAKTLCV 263
Cdd:cd15383   170 FTF-----------FCLFLLPLLIMIFCYTRILL-------EISRRMKEKKDSAKNEVALRSSSDNIPKARMRTLKMTIV 231
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1938531436 264 IMGCFCFCWAPFFVTNI---VDP-FIDYTVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15383   232 IVSSFIVCWTPYYLLGLwywFSPeMLEQTVPESLSHILFLFGLLNACLDPLIYGLFTISFRRGL 295
7tmA_GHSR-like cd15928
growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the ...
29-322 2.11e-18

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes growth hormone secretagogue receptor (GHSR or ghrelin receptor), motilin receptor (also called GPR38), and related proteins. Both GHSR and GPR38 bind peptide hormones. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin is also called the hunger hormone and is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. Motilin, the ligand for GPR38, is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. It is involved in the regulation of digestive tract motility.


Pssm-ID: 320594 [Multi-domain]  Cd Length: 288  Bit Score: 84.46  E-value: 2.11e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  29 VILMAILGNLLVMVAVCRDRQLRKiKTNYFIVSLAFADLLVsVLVMPFGAIELVQD-IWFYGEMFCLVRTSLDVLLTTAS 107
Cdd:cd15928    10 LMLVGASGNLLTVLVIGRSRDMRT-TTNLYLSSLAVSDLLI-FLVLPLDLYRLWRYrPWRFGDLLCRLMYFFSETCTYAS 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 108 IFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVIPmFISFLPI--MQGWNNI-GIVDVIEKRKFNHNSNSTFC 184
Cdd:cd15928    88 ILHITALSVERYLAI-CHPLRAKVLVTRGRVKLLIAVIWAVA-IVSAGPAlvLVGVEHIqGQQTPRGFECTVVNVSSGLL 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 185 VFMVnkpyaiTCSVVAFYIPFLLMVLAYYRIyvtakehaqqiqmlqrAGATSESRPQTADQHSTHRMRTETKAAKTLCVI 264
Cdd:cd15928   166 SVML------WVSTSFFFVPMVCLSLLYGLI----------------GRALWDRRQRSRTAGASRRDNNHRQTVRMLAVI 223
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1938531436 265 MGCFCFCWAPFFVTNIV-------DPFIDYtVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRA 322
Cdd:cd15928   224 VLAFVLCWLPFHVGRVIfnhsrasTKHLHY-VSQYFNLVSFVLFYLSAAINPILYNLMSKRYRYA 287
7tmA_NOFQ_opioid_R cd15092
nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G ...
20-323 2.14e-18

nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The nociceptin (NOP) receptor binds nociceptin or orphanin FQ, a 17 amino acid endogenous neuropeptide. The NOP receptor is involved in the modulation of various brain activities including instinctive and emotional behaviors. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320220 [Multi-domain]  Cd Length: 279  Bit Score: 84.53  E-value: 2.14e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLrKIKTNYFIVSLAFADLLVsVLVMPFGAIELVQDIWFYGEMFCLVRTSL 99
Cdd:cd15092     1 VTIVVVYLIVCVVGLVGNCLVMYVILRHTKM-KTATNIYIFNLALADTLV-LLTLPFQGTDIFLGFWPFGNALCKTVIAI 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 100 DVLLTTASIFHLCCISLDRYYAICcQPLVYRNKMTPLRIALMLGGCWVIPMFISfLPIMQgwnnIGIVDViekrkfnhNS 179
Cdd:cd15092    79 DYYNMFTSTFTLTAMSVDRYVAIC-HPIKALDVRTPHKAKVVNVCIWALASVVG-VPVMV----MGSAQV--------ED 144
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 180 NSTFCVFMVNKP-------YAITCSVVAFYIPFLLMVLAYyriyvtakehAQQIQMLQRAGATSESRPQTADQHSTHRMr 252
Cdd:cd15092   145 EEIECLVEIPTPqdywdpvFGICVFLFSFIIPVLIISVCY----------SLMIRRLRGVRLLSGSKEKDRNLRRITRL- 213
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1938531436 253 tetkaaktLCVIMGCFCFCWAPFFVTNIVDP--FIDYTVPEKVWTAF-LWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15092   214 --------VLVVVAVFVGCWTPIQIFVLAQGlgVQPSSETAVAILRFcTALGYVNSSLNPVLYAFLDENFKACF 279
7tmA_NPFFR2 cd15980
neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G ...
21-323 2.38e-18

neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320646 [Multi-domain]  Cd Length: 299  Bit Score: 84.55  E-value: 2.38e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  21 VLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIkTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSLD 100
Cdd:cd15980     2 VFIASYLLIFLLCMMGNGVVCFIVLRSKHMRTV-TNLFILNLAISDLLVGIFCMPTTLLDNIIAGWPFGSTVCKMSGMVQ 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 101 VLLTTASIFHLCCISLDRYYAIccqplVYrnkmtPLRIALMLGGCWVIPMFISFLPIMQGWNNIGIVDVIEKRKFN---H 177
Cdd:cd15980    81 GISVSASVFTLVAIAVDRFRCI-----VY-----PFKQKLTISTAVVIIVIIWVLAIAIMCPSAVMLHVQEEKNYRvvlG 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 178 NSNSTFCVFM---------VNKPYAITCSVVAFYIPFLLMVLAYYRIYVTakehaqqiqmLQRAGATSESRPQTADQHST 248
Cdd:cd15980   151 SQNKTSPVYWcredwpnqeMRKIYTTVLFANIYLAPLSLIVIMYARIGIT----------LFKTAMPHTGKHNQEQRHVV 220
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 249 HRMRteTKAAKTLCVIMGCFCFCWAPFFVTNIVDPFIDYTVPE------KVWTAFLWLGYINSGLNPFLYAFLNKSFRRA 322
Cdd:cd15980   221 SRKK--QKVIKMLLIVALLFILSWLPLWTLMMLSDYANLSPNQlqiiniYIYPFAHWLAFFNSSVNPIIYGFFNENFRRG 298

                  .
gi 1938531436 323 F 323
Cdd:cd15980   299 F 299
7tmA_GPR39 cd15135
G protein-coupled receptor 39, member of the class A family of seven-transmembrane G ...
21-323 1.04e-17

G protein-coupled receptor 39, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR39 is an orphan G protein-coupled receptor that belongs to the growth hormone secretagogue and neurotensin receptor subfamily. GPR39 is expressed in peripheral tissues such as pancreas, gut, gastrointestinal tract, liver, kidney as well as certain regions of the brain. The divalent metal ion Zn(2+) has been shown to be a ligand capable of activating GPR39. Thus, it has been suggested that GPR39 function as a G(q)-coupled Zn(2+)-sensing receptor which involved in the regulation of endocrine pancreatic function, body weight, gastrointestinal mobility, and cell death.


Pssm-ID: 320263 [Multi-domain]  Cd Length: 320  Bit Score: 82.92  E-value: 1.04e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  21 VLLTFFAMVILMA-ILGNLLVMVAVC---RDRQLRKIKTNYfIVSLAFADLLVSVLVMPfgaIELVQDIWF-----YGEM 91
Cdd:cd15135     1 ITLTLLYSLILVAgILGNSATIKVTQvlqKKGYLQKSVTDH-MVSLACSDLLVLLLGMP---VELYSAIWDpfatpSGNI 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  92 FCLVRTSLDVLLTTASIFHLCCISLDRYYAICcQPLVYRNkMTPLRIALMLGGCWVIPMFISfLPIMQGwnnIGIVDVIE 171
Cdd:cd15135    77 ACKIYNFLFEACSYATILNVATLSFERYIAIC-HPFKYKA-LSGSRVRLLICFVWLTSALVA-LPLLFA---MGTEDPLE 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 172 -----KRKFNH----NSNSTFCVFMVNKPYAITCSVVAFYIPFLLmVLAYYRIYVTAKEHAQQIQMLQR-AGATSESRPQ 241
Cdd:cd15135   151 afpsyRGTRHHcqdqKSNLTICTSLSSKWTVFQASIFSAFVLYLL-VLASVAFMCRRMMRALMGSKKGAvAVKGPGGSVQ 229
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 242 TADQHSTHRMRTETK-AAKTLCVIMGCFCFCWAPFFVTNIVDPfidyTVPEKVWTAFLWLGYI------------NSGLN 308
Cdd:cd15135   230 LLRKHESAEGKTARKqTILFLGLIVGTLAVCWMPNQIRRIMAA----AKPKDDWTRSYFRAYIillpiadtffylSSVLN 305
                         330
                  ....*....|....*
gi 1938531436 309 PFLYAFLNKSFRRAF 323
Cdd:cd15135   306 PLLYNLSSQQFRSVF 320
7tmA_Anaphylatoxin_R-like cd14974
anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class ...
20-323 1.35e-17

anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes anaphylatoxin receptors, formyl peptide receptors (FPR), prostaglandin D2 receptor 2, GPR1, and related chemokine receptors. The anaphylatoxin receptors are a group of G-protein coupled receptors that bind anaphylatoxins. The members of this group include C3a and C5a receptors. The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed mainly on polymorphonuclear and mononuclear phagocytes and bind N-formyl-methionyl peptides (FMLP), which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Chemokine receptor-like 1 (also known as chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. GPR1 is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1.


Pssm-ID: 320105 [Multi-domain]  Cd Length: 274  Bit Score: 81.96  E-value: 1.35e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVM-VAVCRdrqLRKIKTNYFIVSLAFADLLVSVLvMPFGAIELVQDI-WFYGEMFCLVRT 97
Cdd:cd14974     1 IVSLVLYALIFLLGLPGNGLVIwVAGFK---MKRTVNTVWFLNLALADFLFCLF-LPFLIVYIAMGHhWPFGSVLCKLNS 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  98 SLDVLLTTASIFHLCCISLDRYYAICCqPLVYRNKMTPlrialmlGGCWVIPMFISFLPIMQGWNNIGIVDVIEKRkfNH 177
Cdd:cd14974    77 FVISLNMFASVFLLTAISLDRCLLVLH-PVWAQNHRTV-------RLASVVCVGIWILALVLSVPYFVFRDTVTHH--NG 146
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 178 NSNSTFCVFMVN------KPYAITCSVVAFYIPFLLMVLAYYRIYVTakehaqqiqmLQRAGATSESRPqtadqhsthrm 251
Cdd:cd14974   147 RSCNLTCVEDYDlrrsrhKALTVIRFLCGFLLPLLIIAICYSVIAVK----------LRRKRLAKSSKP----------- 205
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 252 rtetkaAKTLCVIMGCFCFCWAPFFVTNIVDpfidyTVPEKVWTAFLWLG--------YINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd14974   206 ------LRVLLAVVVAFFLCWLPYHVFALLE-----LVAAAGLPEVVLLGlplatglaYFNSCLNPILYVFMGQDFRKRL 274
7tmA_Cannabinoid_R cd15099
cannabinoid receptors, member of the class A family of seven-transmembrane G protein-coupled ...
31-323 1.98e-17

cannabinoid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 320227 [Multi-domain]  Cd Length: 281  Bit Score: 81.81  E-value: 1.98e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  31 LMAILGNLLVMVAVCRDRQLRKIKTNYFIVSLAFADLLVSVlvmpFGAIELVQDIWFYGemfclvRTSLDVLLT------ 104
Cdd:cd15099    12 PVTFLENILVLLTILSSTALRRRPSYLFIGSLALADMLASV----IFTISFLDFHVFHQ------RDSRNLFLFklggvt 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 105 ---TASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMqGWNnigivdviekrkfnhnsns 181
Cdd:cd15099    82 mafTASVGSLLLTALDRYLCI-YQPSNYKLLVTRTRAKVAILLMWCVTIIISFLPLM-GWR------------------- 140
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 182 tfCvfmvnKPYAITCSVVAFYIP------------FLLMVLAYYRIYVTAKEHAQQIQMLQragatsesrPQTADQHSTH 249
Cdd:cd15099   141 --C-----KTWDSPCSRLFPYIDrhylaswtglqlVLLFLIIYAYPYILWKAHRHEANMGG---------PKLGRQQVKG 204
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1938531436 250 --RMRTETKAAKTLCVIMGCFCFCWAPFFVTNIVDPFIdyTVPEKVWTAFLW---LGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15099   205 qaRMRMDIRLAKTLSLILLVLAICWLPVLAFMLVDVRV--TLTNKQKRMFAFcsmLCLVNSCVNPIIYALRSRELRGAM 281
7tmA_GPR6 cd15962
G protein-coupled receptor 6, member of the class A family of seven-transmembrane G ...
53-322 3.73e-17

G protein-coupled receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3.


Pssm-ID: 320628 [Multi-domain]  Cd Length: 268  Bit Score: 80.75  E-value: 3.73e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  53 IKTNYFIV--SLAFADLLVSV-LVMPFGAIELVQDiwfygEMFCLVRTSLDVLLTTASIFHLCCISLDRYYAICcQPLVY 129
Cdd:cd15962    31 LRTPMFVLigSLATADLLAGCgLILNFVFQYVIQS-----ETISLITVGFLVASFTASVSSLLAITVDRYLSLY-NALTY 104
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 130 RNKMTPLRIALMLGGCWVIPMFISFLPIMqGWNNIgivdviekrkfnhnSNSTFCvfMVNKPYA---ITCSVVAFYIPFL 206
Cdd:cd15962   105 YSEKTVLGVHLMLAATWGVSLCLGLLPVL-GWNCL--------------EERASC--SIVRPLTksnVTLLSASFFFIFI 167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 207 LMVLAYYRIYVTAKEHAQQIQMLQRAGATSesrpqtadqhstHRMRTEtKAAKTLCVIMGCFCFCWAPFFVTNIVDpfiD 286
Cdd:cd15962   168 LMLHLYIKICKIVCRHAHQIALQQHFLTAS------------HYVATK-KGVSTLAIILGTFGASWLPFAIYCVVG---D 231
                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1938531436 287 YTVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRA 322
Cdd:cd15962   232 HEYPAVYTYATLLPATYNSMINPIIYAYRNQEIQRS 267
7tmA_GPR12 cd15961
G protein-coupled receptor 12, member of the class A family of seven-transmembrane G ...
37-323 4.99e-17

G protein-coupled receptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3.


Pssm-ID: 320627 [Multi-domain]  Cd Length: 268  Bit Score: 80.46  E-value: 4.99e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  37 NLLVMVAVCRDRQLRKiKTNYFIVSLAFADLLVSV-LVMPFGAIELVQDiwfygEMFCLVRTSLDVLLTTASIFHLCCIS 115
Cdd:cd15961    18 NAIVVLIIFQNPSLRA-PMFLLIGSLALADLLAGIgLILNFIFAYLLQS-----EAAKLVTVGLIVASFSASVCSLLAIT 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 116 LDRYYAICcQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMqGWNNIgivdviekrkfnHNSNSTFCVFMVNKPYAIT 195
Cdd:cd15961    92 VDRYLSLY-YALTYNSERTVTFTYVMLVLLWGASICLGLLPVM-GWNCL------------ADESTCSVVRPLTKNNAAI 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 196 CSVvAFYIPFLLMVLAYYRIYVTAKEHAQQIQMLQRAGATSesrpqtadqhstHRMRTEtKAAKTLCVIMGCFCFCWAPF 275
Cdd:cd15961   158 LSV-SFLLMFALMLQLYIQICKIVMRHAHQIALQHHFLATS------------HYVTTR-KGVSTLAIILGTFAACWMPF 223
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1938531436 276 FVTNIVdpfIDYTVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15961   224 TLYSLI---ADYTYPSIYTYATLLPATYNSIINPVIYAFRNQEIQKAL 268
7tmA_TRH-R cd14995
thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G ...
20-323 7.81e-17

thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; TRH-R is a member of the class A rhodopsin-like G protein-coupled receptors, which binds the tripeptide thyrotropin releasing hormone. The TRH-R activates phosphoinositide metabolism through a pertussis-toxin-insensitive G-protein, the G(q)/G(11) class. TRH stimulates the synthesis and release of thyroid-stimulating hormone in the anterior pituitary. TRH is produced in many other tissues, especially within the nervous system, where it appears to act as a neurotransmitter/neuromodulator. It also stimulates the synthesis and release of prolactin. In the CNS, TRH stimulates a number of behavioral and pharmacological actions, including increased turnover of catecholamines in the nucleus accumbens. There are two thyrotropin-releasing hormone receptors in some mammals, thyrotropin-releasing hormone receptor 1 (TRH1) which has been found in a number of species including rat, mouse, and human and thyrotropin-releasing hormone receptor 2 (TRH2) which has, only been found in rodents. These TRH receptors are found in high levels in the anterior pituitary, and are also found in the retina and in certain areas of the brain.


Pssm-ID: 320126 [Multi-domain]  Cd Length: 269  Bit Score: 79.74  E-value: 7.81e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKiKTNYFIVSLAFADLLVSVLVMPFGAIE--LVQDIWFYGEMFCLVRT 97
Cdd:cd14995     1 VVATFLVLLICGVGIVGNIMVVLVVLRTRHMRT-PTNCYLVSLAVADLMVLVAAGLPNEIEslLGPDSWIYGYAGCLLIT 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  98 SLDVLLTTASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLpimqgWnnIGIVDVIEKRKFNH 177
Cdd:cd14995    80 YLQYLGINASSLSITAFTIERYIAI-CHPMKAQFICTVSRAKKIICFVWIFTSLYCSP-----W--LFLLDLSIKHYGDD 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 178 NSNStfCVFMVN----KPYAITCSVVAFYIPFLLMVLAYYRIyvtakehaqqiqmlqrAGATSESRPQTadqhsthrmrt 253
Cdd:cd14995   152 IVVR--CGYKVSrhyyLPIYLADFVLFYVIPLLLAIVLYGLI----------------GRILFSSRKQV----------- 202
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1938531436 254 etkaAKTLCVIMGCFCFCWAPFFVTNIVDPFIDYTVPEKVWTAFL-WLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd14995   203 ----TKMLAVVVVLFALLWMPYRTLVVYNSFASPPYLDLWFLLFCrTCIYLNSAINPILYNLMSQKFRAAF 269
7tmA_NK1R cd16002
neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled ...
26-323 9.41e-17

neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neurokinin 1 receptor (NK1R), also known as tachykinin receptor 1 (TACR1) or substance P receptor (SPR), is a G-protein coupled receptor found in the mammalian central nervous and peripheral nervous systems. The tachykinins act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. SP is an extremely potent vasodilator through endothelium dependent mechanism and is released from the autonomic sensory nerves. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320668 [Multi-domain]  Cd Length: 284  Bit Score: 79.91  E-value: 9.41e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  26 FAMVILMAILGNLLVMVAVCRDRQLRKIkTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSLDVLLTT 105
Cdd:cd16002     7 YSVIVVVSVVGNIIVMWIILAHKRMRTV-TNYFLVNLAFAEASMSAFNTVINFTYAIHNEWYYGLEYCKFHNFFPIAAVF 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 106 ASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMlggcwVIPMFISFLPIMQGWnnIGIVDVIEKRKFNHNSNSTFCV 185
Cdd:cd16002    86 ASIYSMTAIALDRYMAI-IHPLQPRLSATATKVVIC-----VIWVLAFLLAFPQGY--YSDTEEMPGRVVCYVEWPEHEE 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 186 FMVNKPYAITCSVVAFYIPFLLMVLAYyrIYVTAKEHAQQIqmlqragatsesrPQTADQHSTHRMRTETKAAKTLCVIM 265
Cdd:cd16002   158 RKYETVYHVCVTVLIYFLPLLVIGCAY--TVVGITLWASEI-------------PGDSSDRYHEQVSAKRKVVKMMIVVV 222
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1938531436 266 GCFCFCWAPFFVTNIVDPF----IDYTVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd16002   223 CTFAICWLPYHIYFLLQYFhpelYEQKFIQQVYLAIMWLAMSSTMYNPIIYCCLNDRFRVGF 284
7tmA_Apelin_R cd15190
apelin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
20-322 1.01e-16

apelin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Apelin (APJ) receptor is a G protein-coupled receptor that binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake.


Pssm-ID: 341340 [Multi-domain]  Cd Length: 304  Bit Score: 79.81  E-value: 1.01e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIKTNYFIVSLAFADLLVsVLVMPFGAIELVQDI-WFYGEMFCLVRTS 98
Cdd:cd15190    11 ALIPVIYMLVFVLGLSGNGLVLWTVFRSKRKRRRSADTFIANLALADLTF-VVTLPLWAVYTALGYhWPFGSFLCKLSSY 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  99 LDVLLTTASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVIPMFISfLPIMqgwnnigivdVIEKRKFNHN 178
Cdd:cd15190    90 LVFVNMYASVFCLTGLSFDRYLAI-VRSLASAKLRSRTSGIVALGVIWLLAALLA-LPAL----------ILRTTSDLEG 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 179 SNSTFCVF------------MVNKPYAITCSVVAFYIPFLLMVLAYYRIyvtakehaqqiqmlqragatsesrPQTADQH 246
Cdd:cd15190   158 TNKVICDMdysgvvsnesewAWIAGLGLSSTVLGFLLPFLIMLTCYFFI------------------------GRTVARH 213
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 247 STHRMRTETKAAKTLCVIM----GCFCFCWAPFFVTNIVDPFIDYTVPEKVWTAFLWL----------GYINSGLNPFLY 312
Cdd:cd15190   214 FSKLRRKEDKKKRRLLKIIitlvVTFALCWLPFHLVKTLYALMYLGILPFSCGFDLFLmnahpyatclAYVNSCLNPFLY 293
                         330
                  ....*....|
gi 1938531436 313 AFLNKSFRRA 322
Cdd:cd15190   294 AFFDPRFRQQ 303
7tmA_CB2 cd15341
cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G ...
31-322 2.27e-16

cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 320463 [Multi-domain]  Cd Length: 279  Bit Score: 78.73  E-value: 2.27e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  31 LMAILGNLLVMVAVCRDRQLRKIKTNYFIVSLAFADLLVSVLVmpfgAIELVQDIWFYG----EMFCLVRTSLDVLLTtA 106
Cdd:cd15341    12 LLCILENVAVLYLILSSPKLRRKPSYLFIGSLALADFLASVVF----ACSFVDFHVFHGvdssAIFLLKLGGVTMSFT-A 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 107 SIFHLCCISLDRYYAICcQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMqGWNNIGIvdviekrkfnHNSNSTFCVF 186
Cdd:cd15341    87 SLGSLLLMAFDRYVCIY-YPSEYKALVTRKRALVALAVMWVLTALIAYLPLM-GWNCCPL----------NSPCSELFPL 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 187 MVNKPYAITCSVVAfyipFLLMVLAYYRIYVTAKEHAQQIQMLQRagaTSESRPQTAdqhsthRMRTETKAAKTLCVIMG 266
Cdd:cd15341   155 IPNDYLLSWLLLVA----ILLSGIIYTYGHVLWKAHKHVVYMEKH---QDQQGPGNA------RMRLDVRLAKTLGLVLA 221
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1938531436 267 CFCFCWAPFFVTNIVDPFIdyTVPEKVWTAFLW---LGYINSGLNPFLYAFLNKSFRRA 322
Cdd:cd15341   222 VLLICWSPVLALMMHSLFT--SLSDHIKKAFAFcstLCLVNSMVNPIIYALRSRELRSS 278
7tmA_NPSR cd15197
neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled ...
20-323 2.45e-16

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR is widely expressed in the brain, and its activation induces an elevation of intracellular calcium and cAMP concentrations, presumably by coupling to G(s) and G(q) proteins. Mutations in NPSR have been associated with an increased susceptibility to asthma. NPSR was originally identified as an orphan receptor GPR154 and is also known as G protein receptor for asthma susceptibility (GPRA) or vasopressin receptor-related receptor 1 (VRR1).


Pssm-ID: 320325 [Multi-domain]  Cd Length: 294  Bit Score: 78.62  E-value: 2.45e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILmailGNLLVMVAVCRdRQLRKIKTNYFIVSLAFADLLVSVL-VMPfgaiELVQDI---WFYGEMFCLV 95
Cdd:cd15197     5 ATLWVLFVFIVV----GNSSVLFALWM-RKAKKSRMNFFITQLAIADLCVGLInVLT----DIIWRItveWRAGDFACKV 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  96 RTSLDVLLTTASIFHLCCISLDRYYAICcQPLvyrNKMTPLRIA-LMLGGCWvipmFISFLpimqgwNNIGIVDVIEKRK 174
Cdd:cd15197    76 IRYLQVVVTYASTYVLVALSIDRYDAIC-HPM---NFSQSGRQArVLICVAW----ILSAL------FSIPMLIIFEKTG 141
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 175 FNHNSNSTFCVFMVN---KPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAQQIQMLQRAGATSESRPQTADQHSTHRM 251
Cdd:cd15197   142 LSNGEVQCWILWPEPwywKVYMTIVAFLVFFIPATIISICYIIIVRTIWKKSKIQVTINKAGLHDGSSRRSSSRGIIPRA 221
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1938531436 252 RTetKAAKTLCVIMGCFCFCWAPFFVTNIVDPF--IDYTVPEKVWTAFLW-LGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15197   222 KI--KTIKMTFVIVTVFIICWSPYFVFDLLDVFglLPRSKTKIAAATFIQsLAPLNSAINPLIYCLFSTHLCRPL 294
7tmA_NMU-R2 cd15357
neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G ...
26-323 3.08e-16

neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320479 [Multi-domain]  Cd Length: 293  Bit Score: 78.37  E-value: 3.08e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  26 FAMVILMAILGNLLVMVAVCRDRQLrKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWF-YGEMFCLVRTSLDVLLT 104
Cdd:cd15357     7 YAVIFVVGVIGNLLVCLVILKHQNM-KTPTNYYLFSLAVSDLLVLLFGMPLEVYEMWSNYPFlFGPVGCYFKTALFETVC 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 105 TASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVIPMFISfLPimqgwnNIGIVDViekrKFNHNSNSTFC 184
Cdd:cd15357    86 FASILSVTTVSVERYVAI-LHPFRAKLNSTRERALKIIVVLWVLSVLFS-IP------NTSIHGI----KLQYFPNGTLI 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 185 vfmvnkPYAITCSVVA-FYIPFLLMVLAYYRIYVTAKEHAQQIQMLQrAGATSESRPQTADQHSTHRMRTETKA-AKTLC 262
Cdd:cd15357   154 ------PDSATCTVVKpLWIYNLIIQITSLLFYVLPMGVISVLYYLM-GLKLRGDKSLEADEMNVNIQRPSRKSvTKMLF 226
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 263 VIMGCFCFCWAPFFVTNIVDPFI-DYTVP--------EKVWTAFLwlgYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15357   227 VLVLVFAICWAPFHVDRLFFSFVvEWTEPlanvfnliHVVSGVFF---YLSSAVNPIIYNLLSRRFRTAF 293
7tmA_SSTR3 cd15972
somatostatin receptor type 3, member of the class A family of seven-transmembrane G ...
26-323 3.13e-16

somatostatin receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR3 is coupled to inward rectifying potassium channels. SSTR3 plays critical roles in growth hormone secretion, endothelial cell cycle arrest and apoptosis. Furthermore, SSTR3 is expressed in the normal human pituitary and in nearly half of pituitary growth hormone adenomas.


Pssm-ID: 320638 [Multi-domain]  Cd Length: 279  Bit Score: 78.31  E-value: 3.13e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  26 FAMVILMAILGNLLVMVAVCRDRQLRKIkTNYFIVSLAFADLLVsVLVMPFGAIELVQDIWFYGEMFCLVRTSLDVLLTT 105
Cdd:cd15972     7 YLVVCVVGLGGNTLVIYVVLRYSASESV-TNIYILNLALADELF-MLGLPFLAAQNALSYWPFGSFMCRLVMTVDAINQF 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 106 ASIFHLCCISLDRYYAICcQPLVYRNKMTPLRIALMLGGCWVIPmFISFLPIMqgwnnigIVDVIEKRKFNHNSNSTFCV 185
Cdd:cd15972    85 TSIFCLTVMSVDRYLAVV-HPIRSSKWRKPPVAKTVNATVWALS-FLVVLPVV-------IFSGVPGGMGTCHIAWPEPA 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 186 FMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAQQIQMLqragatsesrpqtadqhSTHRMRTETKAAKTLCVIM 265
Cdd:cd15972   156 QVWRAGFIIYTATLGFFCPLLVICLCYLLIVVKVRSSGRRVRAT-----------------STKRRGSERKVTRMVVIVV 218
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1938531436 266 GCFCFCWAPFFVTNIVDPFIDYTVPEKVWTAFLW---LGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15972   219 AAFVLCWLPFYALNIVNLVCPLPEEPSLFGLYFFvvvLSYANSCANPIIYGFLSDNFKQGF 279
7tmA_S1PR2_Edg5 cd15347
sphingosine-1-phosphate receptor subtype 2 (S1PR2 or S1P2), also called endothelial ...
25-323 3.46e-16

sphingosine-1-phosphate receptor subtype 2 (S1PR2 or S1P2), also called endothelial differentiation gene 5 (Edg5), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320469 [Multi-domain]  Cd Length: 266  Bit Score: 77.93  E-value: 3.46e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  25 FFAMVILMAILGNLLVMVAVCRDRQLRKiKTNYFIVSLAFADLLV------SVLVMPFGAIELVQDIWFygemfclVRTS 98
Cdd:cd15347     6 FIVILCCIIVLENLLVLIAVARNKKFHS-AMFFFIGNLAFSDLLAgvafiaNILLSGSVTFRLTPVQWF-------IREG 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  99 LDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTplRIALMLGGCWVIPMFISFLPIMqGWNNIGivdviekrkfnhN 178
Cdd:cd15347    78 TAFITLSASVFSLLAIAIERHVAITKVKLYGSDKNC--RMVLLIGACWVISIVLGGLPIL-GWNCIG------------N 142
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 179 SNSTFCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAQQIqmlqragatseSRPQTadqhsthrmrteTKAA 258
Cdd:cd15347   143 LEDCSTVLPLYSKHYILFVVTIFSIILLSIVILYVRIYCIVRSSHAEM-----------AAPQT------------LALL 199
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1938531436 259 KTLCVIMGCFCFCWAPFFVTNIVDPFIDYTVPEKVWTA--FLWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15347   200 KTVTIVLGVFIVCWLPAFIILLLDTSCKVKSCPILYKAdyFFSVATLNSALNPVIYTLRSKDMRKEF 266
7tmA_Glycoprotein_LRR_R-like cd14980
glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, ...
20-323 5.14e-16

glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the glycoprotein hormone receptors (GPHRs), vertebrate receptors containing 17 leucine-rich repeats (LGR4-6), and the relaxin family peptide receptors (also known as LGR7 and LGR8). They are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone receptor family contains receptors for the pituitary hormones, thyrotropin (thyroid-stimulating hormone receptor), follitropin (follicle-stimulating hormone receptor), and lutropin (luteinizing hormone receptor). Glycoprotein hormone receptors couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein. Two orphan GPCRs, LGR7 and LGR8, have been recently identified as receptors for the relaxin peptide hormones.


Pssm-ID: 320111 [Multi-domain]  Cd Length: 286  Bit Score: 77.67  E-value: 5.14e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIKTNYFIVSLAFADLLVSV--LVMPFGAIELVQDIWFYGE-----MF 92
Cdd:cd14980     1 ISLRIFIWIIGILALIGNILVIIWHISSKKKKKKVPKLLIINLAIADFLMGIylLIIAIADQYYRGRYAQYSEewlrsPP 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  93 CLVRTSLDVLLTTASIFHLCCISLDRYYAIccqplVY---RNKMTPLRIALMLGGCWVIPMFISFLPIMQGWNNIGivdv 169
Cdd:cd14980    81 CLLACFLVSLSSLMSVLMMLLITLDRYICI-----VYpfsNKRLSYKSAKIILILGWLFSIIFAAIPILYSINQPG---- 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 170 iEKRKFNHNSnstFCVFM-VNKPYA---ITCSVVAFYIPFLLMVLAYYRIYVTAKEHAQQIQMLQRagatsesrpqtadq 245
Cdd:cd14980   152 -DNRLYGYSS---ICMPSnVSNPYYrgwLIAYLLLTFIAWIIICILYILIFISVRKSRKSARRSSS-------------- 213
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 246 hsthrmRTETKAAKTLCVIMGCFCFCWAPFFVTNIV----DPFID-YTVPekvWTAFLWLGyINSGLNPFLYAFLNKSFR 320
Cdd:cd14980   214 ------KRDKRIAIRLALILITDLICWLPYYIVIFSglltSTEIDiHVLQ---FIAILALP-LNSAINPYLYTLTTPTFK 283

                  ...
gi 1938531436 321 RAF 323
Cdd:cd14980   284 RDF 286
7tmA_NPY4R cd15397
neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G ...
20-321 5.35e-16

neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320519 [Multi-domain]  Cd Length: 293  Bit Score: 77.86  E-value: 5.35e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIkTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSL 99
Cdd:cd15397     1 VFLVVSYSLVMAVGLLGNICLICVIARQKEKTNV-TNILIANLSFSDILVCLVCLPFTVVYTLMDYWIFGEVLCKMTPFI 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 100 DVLLTTASIFHLCCISLDRYYAIcCQPLVYrnKMTPLRIALMLGGCWVIPMFISfLPIMQgwNNIGIVDVIEKRKFNHNS 179
Cdd:cd15397    80 QCMSVTVSILSLVLIALERHQLI-INPTGW--KPSVSQAYLAVVVIWMLACFIS-LPFLA--FHILTDEPYKNLSHFFAP 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 180 NSTFCVFMVNKP-------YAITCSVVAFYIPFLLMVLAYYRIYVTAKehaQQIQMLQRAGATSEsrpqtadqhsthRMR 252
Cdd:cd15397   154 LADKAVCTESWPsehhklaYTTWLLLFQYCLPLLFILVCYLRIYLRLR---RRKDMLERRGEYNR------------RAG 218
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1938531436 253 TETKAAKTLCVIMGCFCFCWAPFFVTNIVDPFIDYTVP----EKVWTAFLWLGYINSGLNPFLYAFLNKSFRR 321
Cdd:cd15397   219 HSKRINVMLVSLVAAFALCWLPLNVFNAIADWNHEAIPhcqhNLIFSLCHLAAMASTCVNPIIYGFLNSNFKK 291
7tmA_CB1 cd15340
cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G ...
34-323 6.02e-16

cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 320462 [Multi-domain]  Cd Length: 292  Bit Score: 77.64  E-value: 6.02e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  34 ILGNLLVMVAVCRDRQLRKIKTNYFIVSLAFADLLVSVL-VMPFGAIELVQDiwfygemfclvRTSLDVLLT-------- 104
Cdd:cd15340    15 VLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIfVYSFLDFHVFHR-----------KDSPNVFLFklggvtas 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 105 -TASIFHLCCISLDRYYAICcQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMqGWNNIGIvdviekrkfnhNSNSTF 183
Cdd:cd15340    84 fTASVGSLFLTAIDRYISIH-RPLAYKRIVTRTKAVIAFCVMWTIAIVIAVLPLL-GWNCKKL-----------NSVCSD 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 184 CVFMVNKPYaitcsvVAFYI---PFLLMVLAYYRIYVTAKEHAQQIQMLQRAGATS----ESRPQTADQHSTHRMRTETK 256
Cdd:cd15340   151 IFPLIDETY------LMFWIgvtSVLLLFIVYAYMYILWKAHHHAVRMLQRGTQKSiivyTSEDGKVQTTRPDQTRMDIR 224
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 257 AAKTLCVIMGCFCFCWAPFFVTNIVDPFidYTVPEKVWTAFLW---LGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15340   225 LAKTLVLILVVLIICWGPLLAIMVYDVF--GKMNKLIKTVFAFcsmLCLLNSTVNPIIYALRSKDLRHAF 292
7tmA_S1PR5_Edg8 cd15348
sphingosine-1-phosphate receptor subtype 5 (S1PR5 or S1P5), also called endothelial ...
25-322 8.11e-16

sphingosine-1-phosphate receptor subtype 5 (S1PR5 or S1P5), also called endothelial differentiation gene 8 (Edg8), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320470 [Multi-domain]  Cd Length: 277  Bit Score: 76.79  E-value: 8.11e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  25 FFAMVILMAILGNLLVMVAVCRDRQLRKiKTNYFIVSLAFADLL------VSVLVMPFGAIELVQDIWFygemfclVRTS 98
Cdd:cd15348     6 AFLAVCAFIVLENLIVLLALWRNKKFHS-PMFYLLGSLTLSDLLagaayaANILMSGANTLKLTPALWF-------LREG 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  99 LDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTplRIALMLGGCWVIPMFISFLPIMqGWNNIGIVDviekrkfnhn 178
Cdd:cd15348    78 GVFITLTASVFSLLAIAIERHITMVRMKPYPGDKRG--RMFLLIGAAWLVSILLGVLPIL-GWNCLGNLD---------- 144
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 179 SNSTFcVFMVNKPYAITCsVVAFYIPFLLMVLAYYRIYVTAKEHAQQIQML-QRAGATSESRPQTAdqhsthrmrtetkA 257
Cdd:cd15348   145 ACSTV-LPLYAKSYILFC-ITVFLAILAAIVVLYARIYRIVKANSQRLGALpTRKGRARRSQKYLA-------------L 209
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1938531436 258 AKTLCVIMGCFCFCWAPFFVTNIVDPFIDYTVPEKVWTA--FLWLGYINSGLNPFLYAFLNKSFRRA 322
Cdd:cd15348   210 LKTVTIVLGTFVACWLPLFLLLLLDVSCPAQACPVLLKAdyFLGLAMINSLLNPIIYTLTSRDMRRA 276
7tmA_S1PR3_Edg3 cd15345
sphingosine-1-phosphate receptor subtype 3 (S1PR3 or S1P3), also called endothelial ...
25-323 1.18e-15

sphingosine-1-phosphate receptor subtype 3 (S1PR3 or S1P3), also called endothelial differentiation gene 3 (Edg3), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320467 [Multi-domain]  Cd Length: 270  Bit Score: 76.40  E-value: 1.18e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  25 FFAMVILMAILGNLLVMVAVCRDRQLRKiKTNYFIVSLAFADLL------VSVLVMPFGAIELVQDIWFY--GEMFCLVR 96
Cdd:cd15345     6 FFLVICSFIVLENLMVLIAIWKNNRFHN-RMYFFIGNLALCDLLagiaykVNILMSGKKTFSLSPTQWFLreGSMFVALG 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  97 TSLDVLLTTASIFHLCCISLDRYYAiccqplvyrNKMTplRIALMLGGCWVIPMFISFLPIMqGWNNIGIVdviekrkfn 176
Cdd:cd15345    85 ASTFSLLAIAIERHLTMIKMRPYDA---------NKRY--RVFLLIGTCWLISVLLGALPIL-GWNCLDNL--------- 143
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 177 HNSNSTFCVFmvNKPYAITCsVVAFYIPFLLMVLAYYRIYVTAKehaqqiqmlqragatSESRPQTADQHSTHRMrtetK 256
Cdd:cd15345   144 PDCSTILPLY--SKKYVAFC-ISIFIAILVAIVILYARIYILVK---------------SSSRRVTNHRNSERSM----A 201
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1938531436 257 AAKTLCVIMGCFCFCWAPFFVTNIVDPFIDYTVPEKVWTA--FLWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15345   202 LLRTVVIVVGVFIACWSPLFILLLIDVACEVKQCPILYKAdwFIALAVLNSAMNPIIYTLASKEMRRAF 270
7tmA_Prostanoid_R cd14981
G protein-coupled receptors for prostanoids, member of the class A family of ...
24-328 1.43e-15

G protein-coupled receptors for prostanoids, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320112 [Multi-domain]  Cd Length: 288  Bit Score: 76.52  E-value: 1.43e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  24 TFFAMVILMAILGNLLVMVAVCRDRQLRKIKTNY-FIVSLAFADLLVSVLVMPFGAIELVQDIWFYG-------EMFCLV 95
Cdd:cd14981     5 APPALMFVFGVLGNLLALIVLARSSKSHKWSVFYrLVAGLAITDLLGILLTSPVVLAVYASNFEWDGgqplcdyFGFMMS 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  96 RTSLdvllttASIFHLCCISLDRYYAICCqPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMQgwnnigivdviekrkF 175
Cdd:cd14981    85 FFGL------SSLLIVCAMAVERFLAITH-PFFYNSHVKKRRARLMLGAVWAFALLIASLPLLG---------------L 142
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 176 NHNSN---STFCVF------MVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAQQiqmlqragatseSRPQTADQH 246
Cdd:cd14981   143 GSYVLqypGTWCFLdfysknTGDAAYAYLYSILGLLILLVTLLCNLLVIITLLRMRRRK------------KRHRRSRRS 210
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 247 STHRMRTETKAAKTLCVIMGCFCFCWAPFFVTNIVDPFIDYTVPEKVWTAFLWLGYINSGLNPFLYAFlnksFRRAFLII 326
Cdd:cd14981   211 ARRQKRNEIQMVVLLLAITVVFSVCWLPLMIRVLINATGDSEKNGKTDLLAVRMASWNQILDPWVYIL----LRKEVLRR 286

                  ..
gi 1938531436 327 LC 328
Cdd:cd14981   287 LY 288
7tmA_MCHR2 cd15339
melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane ...
20-321 1.43e-15

melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320461 [Multi-domain]  Cd Length: 283  Bit Score: 76.39  E-value: 1.43e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRqlRKIKTNYFIVSLAFADLlVSVLVMPFGAIELVQD-IWFYGEMFCLVRTS 98
Cdd:cd15339     1 VILPSFIGILCSTGLVGNILVLFTIIRSR--KKTVPDIYVCNLAVADL-VHIIVMPFLIHQWARGgEWVFGSPLCTIITS 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  99 LDVLLTTASIFHLCCISLDRYYAICcQP---LVYRNKMTPLRIALMLggcWViPMFISFLPIMqgwnnigIVDVIEKRKF 175
Cdd:cd15339    78 LDTCNQFACSAIMTAMSLDRYIALV-HPfrlTSLRTRSKTIRINLLV---WA-ASFILVLPVW-------VYAKVIKFRD 145
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 176 NHNSnstfCVFMVNKP-----YAITCSVVAFYIPFLLMVLAYYRIYVTAKEhaqQIQMLQRAGATSESRPQtadqhstHR 250
Cdd:cd15339   146 GLES----CAFNLTSPddvlwYTLYQTITTFFFPLPLILICYILILCYTWE---MYRKNKKAGRYNTSIPR-------QR 211
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1938531436 251 MRtetKAAKTLCVIMGCFCFCWAPFFVTNIVD-----PFIDYTVpekVWTAFLWLGYINSGLNPFLYAFLNKSFRR 321
Cdd:cd15339   212 VM---RLTKMVLVLVGVFLVSAAPYHVIQLVNlsvsqPTLAFYV---SYYLSICLSYASSSINPFLYILLSGNFRK 281
7tmA_CXCR5 cd15181
CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G ...
25-323 1.52e-15

CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR5 is a B-cell selective receptor that binds specifically to the homeostatic chemokine CXCL13 and regulates adaptive immunity. The receptor is found on all peripheral blood and tonsillar B cells and is involved in lymphocyte migration (homing) to specific tissues and development of normal lymphoid tissue. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341336 [Multi-domain]  Cd Length: 281  Bit Score: 76.33  E-value: 1.52e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  25 FFAMVILMAILGNLLVMVAVCRDRQLRKIKTNYfIVSLAFADLLVsVLVMPFGAIELVQDiWFYGEMFCLVRTSLDVLLT 104
Cdd:cd15181     6 AYSLVFLLGVVGNGLVLTILLRRRRSRRTTENY-LLHLALADLLL-LLTFPFSVVESIAG-WVFGTFLCKLVGAIHKLNF 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 105 TASIFHLCCISLDRYYAICCQPLVYRNKmTPLRIALMLGGCWVIPMFISfLPimqgwnNIGIVDVIEkrkfNHNSNSTFC 184
Cdd:cd15181    83 YCSSLLLACISVDRYLAIVHAIHSYRHR-RLRSVHLTCGSIWLVCFLLS-LP------NLVFLEVET----STNANRTSC 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 185 VFmvnKPYAITCS-----------VVAFYIPFLLMVLAYYRIYVTAKEHAQQIQmlqragatsesrpqtadqhsthrmrt 253
Cdd:cd15181   151 SF---HQYGIHESnwwltsrflyhVVGFFLPLLIMGYCYATIVVTLCQSSRRLQ-------------------------- 201
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 254 ETKAAKTLCVIMGCFCFCWAPFFVTNIVDPFIDYTVPEKVWTAFL----------WLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15181   202 KQKAIRVAILVTLVFCLCWLPYNIVIFLDTLDDLKAVVKNCKLNDlldaaitvteSLGFSHCCLNPILYAFIGVKFRNDL 281
7tmA_AT1R cd15192
type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
24-323 2.14e-15

type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 320320 [Multi-domain]  Cd Length: 285  Bit Score: 75.93  E-value: 2.14e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  24 TFFAMVILMAILGN-LLVMVAVCrdrqLRKIKT--NYFIVSLAFADLLVsVLVMPFGAIELVQDI-WFYGEMFCLVRTSL 99
Cdd:cd15192     5 TVYSIIFVVGIFGNsLVVIVIYC----YMKLKTvaNIFLLNLALADLCF-LITLPLWAAYTAMEYhWPFGNFLCKIASAL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 100 DVLLTTASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVIPmFISFLPIMQGWNNIgivdviekrkFNHNS 179
Cdd:cd15192    80 VSFNLYASVFLLTCLSIDRYLAI-VHPMKSRLRRTLVVARVTCIVIWLLA-GVASLPAIIHRDVF----------FIENT 147
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 180 NSTFCVFMVNKPY-------AITCSVVAFYIPFLLMVLAYYRIYVTAKEhAQQIQmlqragatsESRPQTADqhsthrmr 252
Cdd:cd15192   148 NITVCAFHYPSQNstllvglGLMKNLLGFLIPFLIILTCYTLIGKALKK-AYEIQ---------RNKPRNDE-------- 209
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 253 tetkAAKTLCVIMGCFCFCWAPFFVTNIVDPFI------DYTVPEKVWTAF---LWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15192   210 ----IFKMIMAVVLFFFFCWIPHQIFTFLDVLIqlkviqDCHIADIVDTAMpftICIAYFNSCLNPILYGFVGKNFRKKF 285
7tmA_LPAR2_Edg4 cd15342
lysophosphatidic acid receptor subtype 2 (LPAR2 or LPA2), also called Endothelial ...
28-323 2.22e-15

lysophosphatidic acid receptor subtype 2 (LPAR2 or LPA2), also called Endothelial differentiation gene 4 (Edg4), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320464 [Multi-domain]  Cd Length: 274  Bit Score: 75.60  E-value: 2.22e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  28 MVILMAILGNLLVMVAVCRDRQLRKiKTNYFIVSLAFADLLVSVLVM-------PFGAiELVQDIWFYGEmfCLVRTSLd 100
Cdd:cd15342     9 TVSVIVLLTNLLVIAAIFINRRFHY-PIYYLLGNLAAADLFAGVAYLflmfhtgPWTA-KLSLYQWFLRQ--GLLDTSL- 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 101 vlltTASIFHLCCISLDRYYAICCQPLvyRNKMTPLRIALMLGGCWVIPMFISFLPIMqGWNNIGIVDviekrkfnhnsN 180
Cdd:cd15342    84 ----TASVANLLAIAVERHQTIFTMQL--HSKMSNQRVVILIFGIWMVALILGLIPAM-GWNCLCDLK-----------R 145
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 181 STFCVFMVNKPYAITCSVVAFyIPFLLMVLAYYRIYVTAKEHAQQIqmlqragatsesrpqtADQHSTHRMRTETKAA-- 258
Cdd:cd15342   146 CSTMAPLYSRSYLVFWALSNL-LTFLIMVAVYTRIFIYVRRKSQRM----------------SEHHSSHPRYRETVLGlm 208
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1938531436 259 KTLCVIMGCFCFCWAPFFVTNIVDPF----IDYTVPEKVwtaFLWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15342   209 KTVVIILGAFVVCWTPGQVVLLLDGLgcesCNVLAYEKY---FLLLAEINSLVNPIVYSYRDKEMRKTF 274
7tmA_GPR150 cd15198
G protein-coupled receptor 150, member of the class A family of seven-transmembrane G ...
23-316 3.34e-15

G protein-coupled receptor 150, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors. Its endogenous ligand is not known. These receptors share a significant amino acid sequence similarity, suggesting that they have a common evolutionary origin.


Pssm-ID: 320326 [Multi-domain]  Cd Length: 299  Bit Score: 75.61  E-value: 3.34e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  23 LTFFAMVILMAILGNLLVMVAVCRDRQlRKIKTNYFIVSLAFADLLVSVLVMPFGAI-ELVQDIWFYGEMFCLVRTSLDV 101
Cdd:cd15198     4 LIFLGVILVAGVAGNTTVLCWLCGGRR-RKSRMNFLLLQLALADLLVIGGTALSQIIwELLGDRWMAGDVACRLLKLLQA 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 102 LLTTASIFHLCCISLDRYYAIcCQPLvyrnkMTPLRIALMLGGCWVIPMFISFLP--IMQGwnniGIVDVIEKRKFNHns 179
Cdd:cd15198    83 SARGASANLVVLLALDRHQAI-RAPL-----GQPLRAWKLAALGWLLALLLALPQayVFRV----DFPDDPASAWPGH-- 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 180 nsTFCVFMVN-------KPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAQQIQMLQRAGATSESRPQTAdQHSTHRMR 252
Cdd:cd15198   151 --TLCRGIFAplprwhlQVYATYEAVVGFVAPVVILGVCYGRLLLKWWERANQAPGAKKPWKKPSKSHLRA-TAPSALPR 227
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1938531436 253 TETKAAKTLCVIMGCFCFCWAPFFVTNIVDPFIDYT-VPEKVWTAFLWLGYINSGLNPFLYAFLN 316
Cdd:cd15198   228 AKVKTLKMTLVIALLFVGCSLPYFIAELAAAFGSGDwEPEKVAAALGVMAVANSATNPFVFLFFN 292
7tmA_GHSR cd15131
growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G ...
27-322 4.64e-15

growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Growth hormone secretagogue receptor, GHSR, is also known as GH-releasing peptide receptor (GHRP) or Ghrelin receptor. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin, also called hunger hormone, is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. It also plays a role in the cardiovascular, immune, and reproductive systems. GHSR couples to G-alpha-11 proteins. Both ghrelin and GHSR are expressed in a wide range of cancer tissues. Recent studies suggested that ghrelin may play a role in processes associated with cancer progression, including cell proliferation, metastasis, apoptosis, and angiogenesis.


Pssm-ID: 320259 [Multi-domain]  Cd Length: 291  Bit Score: 74.92  E-value: 4.64e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  27 AMVILMAILGNLLVMVAVCRDRQLRKiKTNYFIVSLAFADLLVsVLVMPFGAIELVQ-DIWFYGEMFCLVRTSLDVLLTT 105
Cdd:cd15131     8 VLLFVVGVTGNLMTMLVVSKYRDMRT-TTNLYLSSMAFSDLLI-FLCMPLDLYRLWQyRPWNFGDLLCKLFQFVSESCTY 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 106 ASIFHLCCISLDRYYAICCqPLVYRNKMTPLRIALMLGGCWVIPmFISFLPI-----MQGWNNIGIVDVIEKRKFNHNSN 180
Cdd:cd15131    86 STILNITALSVERYFAICF-PLRAKVVVTKRRVKLVILVLWAVS-FLSAGPIfvlvgVEHENGTNPIDTNECKATEYAVR 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 181 STFCVFMVnkpyaiTCSVVAFYIPFLLMVLAYYRIYvtakehaqqiQMLQRagatseSRPQTADQHSTHRMRTETKAAKT 260
Cdd:cd15131   164 SGLLTIMV------WVSSVFFFLPVFCLTVLYSLIG----------RKLWR------RRRENIGPNASHRDKNNRQTVKM 221
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 261 LCVIMGCFCFCWAPFFVTNIV--------DPFIDYTVPEKVWTAFLwLGYINSGLNPFLYAFLNKSFRRA 322
Cdd:cd15131   222 LAVVVFAFVLCWLPFHVGRYLfsksfeagSLEIALISQYCNLVSFV-LFYLSAAINPILYNIMSKKYRVA 290
7tmA_MCR cd15103
melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
26-323 5.73e-15

melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320231 [Multi-domain]  Cd Length: 270  Bit Score: 74.45  E-value: 5.73e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  26 FAMVILMAILGNLLVMVAVCRDRQLRKiKTNYFIVSLAFADLLVSV-------LVMPFGAIELVQDIWFYGEMFCLVrTS 98
Cdd:cd15103     7 FLTLGIVSLLENILVILAIAKNKNLHS-PMYFFICSLAVADMLVSVsnaletiVIILLNNGYLVPRDSFEQHIDNVI-DS 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  99 LDVLLTTASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVipmfisflpimqgwnnigivdviekrkFNHN 178
Cdd:cd15103    85 MICSSLLASICSLLAIAVDRYITI-FYALRYHSIMTVRRAGVIITAIWV---------------------------FCTV 136
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 179 SNSTFCVFMVNKPyAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAQQIQMLQRAGATsesrpqtadqhsthRMRTETKAA 258
Cdd:cd15103   137 CGILFIIYSDSVP-VIICLISMFFAMLVLMASLYVHMFLLARSHVKKIAALPGQRST--------------RQRANMKGA 201
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1938531436 259 KTLCVIMGCFCFCWAPFF---VTNIVDPFIDYTVP-EKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15103   202 VTLTILLGVFIFCWAPFFlhlTLMISCPSNPYCACyMSHFNVYLILIMCNSVIDPLIYAFRSQELRKTF 270
7tmA_GPR185-like cd15960
G protein-coupled receptor 185 and similar proteins, member of the class A family of ...
37-323 5.95e-15

G protein-coupled receptor 185 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR185, also called GPRx, is a member of the constitutively active GPR3/6/12 subfamily of G protein-coupled receptors. It plays a role in the maintenance of meiotic arrest in Xenopus laevis oocytes through G(s) protein, which leads to increased cAMP levels. In Xenopus laevis, GPR185 is primarily expressed in brain, ovary, and testis; however, its ortholog has not been identified in other vertebrate genomes. GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest.


Pssm-ID: 320626 [Multi-domain]  Cd Length: 268  Bit Score: 74.16  E-value: 5.95e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  37 NLLVMVAVCRDRQLRKiKTNYFIVSLAFADLLVSV-LVMPFGAIELvqdiwFYGEMFCLVRTSLDVLLTTASIFHLCCIS 115
Cdd:cd15960    18 NAIVIAILFYTPSLRA-PMFILIGSLALADLLAGLgLIANFVAIYV-----MNSEAVTLCSAGLLLAAFSASVCSLLAIT 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 116 LDRYYAICcQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMqGWNNigivdviekrkFNHNSNSTFCVfMVNKPYAIT 195
Cdd:cd15960    92 VDRYLSLY-NALTYHTERTLTFTYGLLALLWLTCIGIGLLPAM-GWNC-----------LRAPASCSVLR-PVTKNNAAV 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 196 CSVvAFYIPFLLMVLAYYRIYVTAKEHAQQIQMLQRAGATSESRpqtadqhsthrmrTETKAAKTLCVIMGCFCFCWAPF 275
Cdd:cd15960   158 LAV-SFLLLFALMMQLYLQICRIAFRHAQQIAVQHQFVNFCLAS-------------STRKGVSTLSLILATFAFCWVPF 223
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1938531436 276 FVTNIVdpfIDYTVPEkVWTAFLWL-GYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15960   224 AVYSMV---ADSSYPM-IYTYYLVLpAACNSVINPIIYAFRNPDIQKSL 268
7tmA_NMU-R1 cd15358
neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G ...
26-323 6.32e-15

neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320480 [Multi-domain]  Cd Length: 305  Bit Score: 74.81  E-value: 6.32e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  26 FAMVILMAILGNLLVMVAVCRDRQLRKiKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWF-YGEMFCLVRTSLDVLLT 104
Cdd:cd15358     7 YLLIFVVGAVGNGLTCIVILRHKVMRT-PTNYYLFSLAVSDLLVLLLGMPLELYEMWSNYPFlLGAGGCYFKTLLFETVC 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 105 TASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVIPMFISfLPimqgwnNIGIVDVIEKRKFNHNSNSTFC 184
Cdd:cd15358    86 FASILNVTALSVERYIAV-VHPLKAKYVVTRTHAKRVIGAVWVVSILCS-IP------NTSLHGIFQLTVPCRGPVPDSA 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 185 VFMVNKPYAI------TCSVVAFYIPFLLMVLAYYRIYVTAKEHAQQIQMLQRAGATSESRPQTADQHSTHRMRTETKAA 258
Cdd:cd15358   158 TCMLVKPRWMynliiqITTLLFFFLPMGTISVLYLLIGLQLKREKMLLVLEAKGSKAGDSYQHRRIQQEKRRRRQVTKML 237
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1938531436 259 KTLCVIMGcfcFCWAPFFVTNIVDPFID------YTVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15358   238 FVLVVVFG---ICWAPFHTDRLMWSFISqwtgelHLAFQYVHIISGVFFYLSSAANPVLYNLMSTRFREMF 305
7tmA_NPY1R cd15395
neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G ...
20-321 6.43e-15

neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320517 [Multi-domain]  Cd Length: 293  Bit Score: 74.47  E-value: 6.43e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIkTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSL 99
Cdd:cd15395     1 FTLALAYSAVIILGVSGNLALIIIILKQKEMHNV-TNILIVNLSFSDLLMTIMCLPFTFVYTLMDHWVFGEAMCKLNSMV 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 100 DVLLTTASIFHLCCISLDRYYAIcCQPLVYR--NKMTPLRIALMlggcWVIPMFISfLPIMqgwnnigIVDVIEKRKFNH 177
Cdd:cd15395    80 QCISITVSIFSLVLIAIERHQLI-INPRGWRpnNRHAYVGIAVI----WVLAVLTS-LPFL-------IFQVLTDEPFKN 146
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 178 NSNS------------TFCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYvtakehaqqIQMLQRAGATSESRPQTADQ 245
Cdd:cd15395   147 VNVSldaykgkyvcldQFPSDTIRLSYTTCLLVLQYFGPLCFIFICYLKIY---------IRLKRRNNMMDKMRDNKYRS 217
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 246 HSTHRMRTetkaakTLCVIMGCFCFCWAPFFVTNIVdpfIDYTvPEKVWTA---FLWL-----GYINSGLNPFLYAFLNK 317
Cdd:cd15395   218 SETKRINI------MLISIVVAFAVCWLPLNIFNAV---FDWN-HEAIATCnhnLLFLichltAMISTCVNPIFYGFLNK 287

                  ....
gi 1938531436 318 SFRR 321
Cdd:cd15395   288 NFQR 291
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
29-323 7.85e-15

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 74.21  E-value: 7.85e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  29 VILMAILGNLLVMVAVCRDRqLRKIkTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGE-----MFCLVRTSLDVLL 103
Cdd:cd14978    10 ICIFGIIGNILNLVVLTRKS-MRSS-TNVYLAALAVSDILVLLSALPLFLLPYIADYSSSFLsyfyaYFLPYIYPLANTF 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 104 TTASIFHLCCISLDRYYAICCqPLVYRNKMTPLRIALMLGGCWV------IPMF--ISFLPIMQGWNNIGIVDVIEKRKF 175
Cdd:cd14978    88 QTASVWLTVALTVERYIAVCH-PLKARTWCTPRRARRVILIIIIfslllnLPRFfeYEVVECENCNNNSYYYVIPTLLRQ 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 176 NHNSNSTFCVFMVnkpyaitcSVVAFYIPFLLMVLAYYRIyvtakehaqqIQMLQRAGATSESRPQTADQHsTHRMRTET 255
Cdd:cd14978   167 NETYLLKYYFWLY--------AIFVVLLPFILLLILNILL----------IRALRKSKKRRRLLRRRRRLL-SRSQRRER 227
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1938531436 256 KAAKTLCVIMGCFCFCWAPFFVTNIVDPFIDYTVPEKVWTAFL----WLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd14978   228 RTTIMLIAVVIVFLICNLPAGILNILEAIFGESFLSPIYQLLGdisnLLVVLNSAVNFIIYCLFSSKFRRTF 299
7tmA_Glyco_hormone_R cd15136
glycoprotein hormone receptors, member of the class A family of seven-transmembrane G ...
28-321 9.93e-15

glycoprotein hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors (GPHRs) are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG) and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. GPHRs couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein.


Pssm-ID: 320264 [Multi-domain]  Cd Length: 275  Bit Score: 73.79  E-value: 9.93e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  28 MVILMAILGNLLVMVAVCRDRQLRKIkTNYFIVSLAFADLLVSVLVmpfgAIELVQDIWFYGEMF-----------CLVR 96
Cdd:cd15136     9 FVFLLALVGNIIVLLVLLTSRTKLTV-PRFLMCNLAFADFCMGIYL----GLLAIVDAKTLGEYYnyaidwqtgagCKTA 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  97 TSLDVLLTTASIFHLCCISLDRYYAICcQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPImqgwnnigivdviekrkFN 176
Cdd:cd15136    84 GFLAVFSSELSVFTLTVITLERWYAIT-HAMHLNKRLSLRQAAIIMLGGWIFALIMALLPL-----------------VG 145
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 177 HNSNSTFCVFM-------VNKPYAITCSVVAFyIPFLLMVLAYYRIYVTAKEhaqqiqmlqragatSESRPQTADqhsth 249
Cdd:cd15136   146 VSSYSKTSICLpfetetpVSKAYVIFLLLFNG-LAFLIICGCYIKIYLSVRG--------------SGRAANSND----- 205
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1938531436 250 rmrteTKAAKTLCVIMGCFCFCWAP--FF-VTNIVD-PFIDYTVpEKVWTAFLWLgyINSGLNPFLYAFLNKSFRR 321
Cdd:cd15136   206 -----TRIAKRMALLVFTDFLCWAPiaFFgLTAAFGlPLISVSN-AKILLVFFYP--LNSCANPFLYAIFTKQFRR 273
7tmA_Bradykinin_R cd15189
bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
21-321 1.00e-14

bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320317 [Multi-domain]  Cd Length: 284  Bit Score: 73.66  E-value: 1.00e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  21 VLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIKTNYfIVSLAFADLlVSVLVMPFGAIELVQDI-WFYGEMFCLVRTSL 99
Cdd:cd15189     2 IIPPFIFSLCLFGLLGNLFVLLVFLLHRRRLTVAEIY-LGNLAAADL-VFVSGLPFWAMNILNQFnWPFGELLCRVVNGV 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 100 DVLLTTASIFHLCCISLDRYYAiccqpLVYRNKMTPLR----------IALMLGGCWVIPMFisflpimqgwnnigivdV 169
Cdd:cd15189    80 IKVNLYTSIYLLVMISQDRYLA-----LVKTMAARRLRrrryaklicvLIWVVGLLLSIPTF-----------------L 137
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 170 IEKRKFNHNSNSTFCVFMV-NKPYAIT----CSVVAFYIPFLLMVLAYYRIYVTAKEHAQQiqmlqragatsesrpqtad 244
Cdd:cd15189   138 LRKIKAIPDLNITACVLLYpHEAWHFAhivlLNIVGFLLPLLVITFCNYNILQALRTREES------------------- 198
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 245 qhSTHRMRTETKAAKTLCVIMGCFCFCWAPFFVTNIVDPFIDYTV-PEKVWTAFL--------WLGYINSGLNPFLYAFL 315
Cdd:cd15189   199 --TRCEDRNDSKATALVLAVTLLFLVCWGPYHFFTFLDFLFDVGVlDECFWEHFIdiglqlavFLAFSNSCLNPVLYVFV 276

                  ....*.
gi 1938531436 316 NKSFRR 321
Cdd:cd15189   277 GRYFRR 282
7tmA_NTSR1 cd15355
neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G ...
20-323 1.61e-14

neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320477 [Multi-domain]  Cd Length: 310  Bit Score: 73.73  E-value: 1.61e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIKT--NYFIVSLAFADLLVSVLVMPfgaIELVQDIWF-----YGEMF 92
Cdd:cd15355     1 VLVTAIYLALFVVGTVGNSITLYTLARKKSLQHLQStvHYHLASLALSDLLILLLAMP---VELYNFIWVhhpwaFGDAA 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  93 CLVRTSLDVLLTTASIFHLCCISLDRYYAICcQPLVYRNKMTPLRIALMLGGCWV------IPMfisflpimqgwnnigI 166
Cdd:cd15355    78 CRGYYFLRDACTYATALNVASLSVERYLAIC-HPFKAKSLMSRSRTKKFISAIWLasallaIPM---------------L 141
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 167 VDVIEKRKFNHNSNSTFCVFMVNKPYAITCSVVAFYIPFLLMVLAY--------YRIYVTAKEHAQQIQMLQRAGatseS 238
Cdd:cd15355   142 FTMGEQNRSGTHPGGLICTPIVDTSTLKVVIQVNAFLSFLFPMLVIsvlntliaNQLTVMVNQAEQENQVCTIGG----Q 217
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 239 RPQTADQHSTHRMRTETKAAKTLCVIMGCFCFCWAPFFVTNIVDPFidytVPEKVWTAFLW------------LGYINSG 306
Cdd:cd15355   218 RTVLSVSMEPGRVQSLRHGVLVLRAVVIAFVVCWLPYHVRRLMFCY----VSDEQWTTFLYdfyhyfymltnvLFYVSSA 293
                         330
                  ....*....|....*..
gi 1938531436 307 LNPFLYAFLNKSFRRAF 323
Cdd:cd15355   294 INPILYNLVSANFRQIF 310
7tmA_CCR10 cd15177
CC chemokine receptor type 10, member of the class A family of seven-transmembrane G ...
24-321 1.67e-14

CC chemokine receptor type 10, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR10 is a homeostatic receptor specific for two C-C motif chemokines, CCL27 and CCL28. Activation of CCR10 by its two ligands mediates diverse activities, ranging from leukocyte trafficking to skin cancer. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341332 [Multi-domain]  Cd Length: 280  Bit Score: 73.27  E-value: 1.67e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  24 TFFAMVILMAILGNLLVMVAVCRDRQLRKIkTNYFIVSLAFADLLVsVLVMPFGAIELVQDiWFYGEMFCLVRTSLDVLL 103
Cdd:cd15177     5 CVYLVVFVLGLVGNGLVLATHTRYRRLRSM-TDVYLLNLALADLLL-LLTLPFAAAETLQG-WIFGNAMCKLIQGLYAIN 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 104 TTASIFHLCCISLDRYYAICCQPLVYR-NKMTPLRIALMLGGCWVIPMFISfLPIMqgwnnigIVDVIEKRKFNHNSNST 182
Cdd:cd15177    82 FYSGFLFLTCISVDRYVVIVRATSAHRlRPKTLFYSVLTSLIVWLLSILFA-LPQL-------IYSRVENRSELSSCRMI 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 183 F---CVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTakehaqqiqMLQRAGatseSRPQtadqhsthrmrtetKAAK 259
Cdd:cd15177   154 FpevVSRTVKGATALTQVVLGFAIPLIVMAVCYAAIGRT---------LLAARG----WERH--------------RALR 206
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1938531436 260 TLCVIMGCFCFCWAPFFVTNIVD---PFIDYTVPEKVWT----AFL---WLGYINSGLNPFLYAFLNKSFRR 321
Cdd:cd15177   207 VIAALVVAFVLFQLPYSVVLLLDtadLLATLELSCSQSKrkdiALLvtsGLAYVRCCLNPLLYAFVGVRFRR 278
7tmA_Relaxin_R cd15137
relaxin family peptide receptors, member of the class A family of seven-transmembrane G ...
21-323 2.09e-14

relaxin family peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes relaxin/insulin-like family peptide receptor 1 (RXFP1 or LGR7) and 2 (RXFP2 or LGR8), which contain a very large extracellular N-terminal domain with numerous leucine-rich repeats responsible for hormone recognition and binding. Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four GPCRs, RXFP1-4. Relaxin and INSL3 are the endogenous ligands for RXFP1 and RXFP2, respectively. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP.


Pssm-ID: 320265 [Multi-domain]  Cd Length: 284  Bit Score: 73.00  E-value: 2.09e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  21 VLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIKTNyFIVSLAFADLLVSVLVMPFGAielvQDIWFYGEMF-------- 92
Cdd:cd15137     2 VLRVFIWVVGIIALLGNLFVLIWRLKYKEENKVHSF-LIKNLAIADFLMGVYLLIIAS----VDLYYRGVYIkhdeewrs 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  93 ---CLVRTSLDVLLTTASIFHLCCISLDRYYAICcqpLVYRNKMTPLRIALMLGGC-WVIPMFISFLPimqgwnnigivd 168
Cdd:cd15137    77 swlCTFAGFLATLSSEVSVLILTLITLDRFICIV---FPFSGRRLGLRRAIIVLACiWLIGLLLAVLP------------ 141
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 169 VIEKRKFNH-NSNSTFC-------VFMVNKPYaitcSVVAF----YIPFLLMVLAYYRIYVTAKehaqqiqmlqragats 236
Cdd:cd15137   142 LLPWDYFGNfYGRSGVClplhitdERPAGWEY----SVFVFlglnFLAFVFILLSYIAMFISIR---------------- 201
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 237 esrpQTADQHSTHRMRTETKAAKTLCVIMGCFCFCWAPFFVTNIVdPFIDYTVPEKV--WTAFLWLGyINSGLNPFLYAF 314
Cdd:cd15137   202 ----RTRKAAASRKSKRDMAVAKRFFLIVLTDFLCWIPIIVIGIL-ALSGVPIPGEVyaWVAVFVLP-INSALNPILYTL 275

                  ....*....
gi 1938531436 315 LNKSFRRAF 323
Cdd:cd15137   276 STPKFRKKL 284
7tmA_MC1R cd15351
melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G ...
26-321 2.37e-14

melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320473 [Multi-domain]  Cd Length: 271  Bit Score: 72.52  E-value: 2.37e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  26 FAMVILMAILGNLLVMVAVCRDRQLRKiKTNYFIVSLAFADLLVSVLVMPFGAIELVQD---IWFYGEMFCLVRTSLDVL 102
Cdd:cd15351     7 FLFLGLVSLVENILVVVAIAKNRNLHS-PMYYFICCLAVSDMLVSVSNLIETLFMLLLEhgvLVCRAPMLQHMDNVIDTM 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 103 LTTA---SIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMQgwnnigivdviekrkfnHNS 179
Cdd:cd15351    86 ICSSvvsSLSFLGAIAVDRYITI-FYALRYHSIMTLQRAVNAIAGIWLASTVSSTLFIVY-----------------YNS 147
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 180 NSTfcvfmvnkpyaITCSVVAFYIPFLLMVLAYYRIYVTAKEHAQQIQMLQRagatsesrpqtadQHSTHRMRTETKAAK 259
Cdd:cd15351   148 NAV-----------ILCLIVFFLFMLVLMLVLYIHMFILACRHSQSISSQQR-------------RQCPHQQTASLKGAI 203
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1938531436 260 TLCVIMGCFCFCWAPFF------VTNIVDPFIdyTVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRR 321
Cdd:cd15351   204 TLTILLGIFFLCWGPFFlhltliVTCPTHPFC--LCYFKYFNLFLILIICNSIIDPLIYAFRSQELRK 269
7tmA_MC5R cd15354
melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G ...
26-323 3.89e-14

melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320476 [Multi-domain]  Cd Length: 270  Bit Score: 71.89  E-value: 3.89e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  26 FAMVILMAILGNLLVMVAVCRDRQLRKiKTNYFIVSLAFADLLVSV-------LVMPFGAIELVQDIWFYGEMFClVRTS 98
Cdd:cd15354     7 FLTLGIISLLENILVILAIVKNKNLHS-PMYFFVCSLAVADMLVSVsnawetiTIYLLNNRHLVIEDAFVRHIDN-VFDS 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  99 LDVLLTTASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVIPmfisflpimqgwNNIGIVDVIEkrkfnhn 178
Cdd:cd15354    85 LICISVVASMCSLLAIAVDRYVTI-FYALRYHNIMTVRRAGIIIACIWTFC------------TGCGIIFILY------- 144
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 179 SNSTfcvfmvnkpYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAQQIQMLQRAgatsesrpqtadqhSTHRMRTETKAA 258
Cdd:cd15354   145 SEST---------YVIICLITMFFAMLFLMVSLYIHMFLLARTHVKRIAALPGY--------------NSVRQRTSMKGA 201
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1938531436 259 KTLCVIMGCFCFCWAPFFVTNIvdpfIDYTVPEKVWTA--------FLWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15354   202 VTLTILLGIFIVCWAPFFLHLI----LMISCPQNLYCVcfmshfnmYLILIMCNSVIDPLIYAFRSQEMRKTF 270
7tmA_GPR3 cd15963
G protein-coupled receptor 3, member of the class A family of seven-transmembrane G ...
58-321 4.62e-14

G protein-coupled receptor 3, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3.


Pssm-ID: 320629 [Multi-domain]  Cd Length: 268  Bit Score: 71.84  E-value: 4.62e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  58 FIVSLAFADLLVSV-LVMPFGAIELVQDiwfygEMFCLVRTSLDVLLTTASIFHLCCISLDRYYAICcQPLVYRNKMTPL 136
Cdd:cd15963    38 LIGSLATADLLAGLgLILHFAFVYCIQS-----APVNLVTVGLLAPSFTASVSSLLAITIDRYLSLY-NALTYYSERTVT 111
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 137 RIALMLGGCWVIPMFISFLPIMqGWNNIgivdviekrkfnHNSNSTFCVFMVNKPYAITCSVvAFYIPFLLMVLAYYRIY 216
Cdd:cd15963   112 RTYIMLILTWGASLCLGLLPVV-GWNCL------------KDPSTCSVVKPLTKNHLVILSI-SFFMVFALMLQLYAQIC 177
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 217 VTAKEHAQQIQMLQRAGATSesrpqtadqhstHRMRTEtKAAKTLCVIMGCFCFCWAPFFVTNIVDpfiDYTVPEKVWTA 296
Cdd:cd15963   178 RIVCRHAHQIALQRHFLPTS------------HYVTTR-KGIATLAVILGTFASCWLPFAVYCLLG---DYTYPALYTYA 241
                         250       260
                  ....*....|....*....|....*
gi 1938531436 297 FLWLGYINSGLNPFLYAFLNKSFRR 321
Cdd:cd15963   242 TLLPATYNSMINPIIYAFRNQEIQK 266
7tmA_NPBWR cd15087
neuropeptide B/W receptors, member of the class A family of seven-transmembrane G ...
20-323 7.29e-14

neuropeptide B/W receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide B/W receptor 1 and 2 are members of the class A G-protein coupled receptors that bind the neuropeptides B and W, respectively. NPBWR1 (previously known as GPR7) is expressed predominantly in cerebellum and frontal cortex, while NPBWR2 (previously known as GPR8) is located mostly in the frontal cortex and is present in human, but not in rat and mice. These receptors are suggested to be involved in the regulation of food intake, neuroendocrine function, and modulation of inflammatory pain, among many others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320215 [Multi-domain]  Cd Length: 282  Bit Score: 71.31  E-value: 7.29e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIkTNYFIVSLAFADLLVsVLVMPFGAIELVQDIWFYGEMFCLVRTSL 99
Cdd:cd15087     1 VALPVIYSVICAVGLTGNTAVIYVILRAPKMKTV-TNVFILNLAIADDLF-TLVLPINIAEHLLQQWPFGELLCKLILSI 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 100 DVLLTTASIFHLCCISLDRYYAIccqPLVYRNKMTP---LRIALMLGGCWVIPMFISFLPImqgwnnigivdVIEKRKFN 176
Cdd:cd15087    79 DHYNIFSSIYFLTVMSVDRYLVV---LATVRSRRMPyrtYRAAKIVSLCVWLLVTIIVLPF-----------TVFAGVYS 144
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 177 HNSNSTFCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTakehaqQIQMLQRAGATSESRPQTADQHSTHRMRTetk 256
Cdd:cd15087   145 NELGRKSCVLSFPSPESLWFKASRIYTLVLGFAIPVSTICIL------YTMMLYKLRNMRLNSNAKALDKAKKKVTL--- 215
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 257 aaKTLCVIMGCFcFCWAPFFVTNIVDPFIDY-TVPEKVWTAFLW--LGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15087   216 --MVLVVLAVCL-FCWTPFHLSTVVALTTDLpQTPLVIGISYFItsLSYANSCLNPFLYAFLDDSFRKSF 282
7tmA_GPR17 cd15161
G protein-coupled receptor 17, member of the class A family of seven-transmembrane G ...
20-323 8.17e-14

G protein-coupled receptor 17, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR17 is a Forkhead box protein O1 (FOXO1) target and abundantly expressed in agouti-related peptide (AGRP) neurons. FOXO1 is a transcription factor that plays key roles in regulation of gluconeogenesis and glycogenolysis by insulin signaling. For instance, food intake and body weight increase when hypothalamic FOXO1 is activated, whereas they both decrease when FOXO1 is inhibited. However, a recent study has been reported that GPR17 deficiency in mice did not affect food intake or glucose homeostasis. Thus, GPR17 may not play a role in the control of food intake, body weight, or glycemic control. GPR17 is phylogenetically closely related to purinergic P2Y and cysteinyl-leukotriene receptors.


Pssm-ID: 320289 [Multi-domain]  Cd Length: 277  Bit Score: 70.89  E-value: 8.17e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQlRKIKTNYFIVSLAFADLLVsVLVMPFGAI-ELVQDIWFYGEMFCLVRTS 98
Cdd:cd15161     1 ILFALFYILVFILAFPGNTLALWLFIHDRK-SGTPSNVFLMHLAVADLSY-VLILPMRLVyHLSGNHWPFGEVPCRLAGF 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  99 LDVLLTTASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVIpMFISFLPIMQGWNNIGIVDVIEKRKFNHN 178
Cdd:cd15161    79 LFYLNMYASLYFLACISVDRFLAI-VHPVKSMKIRKPLYAHVVCGFLWVI-VTVAMAPLLVSPQTVEVNNTTVCLQLYRE 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 179 SNSTFcvfmvnkpyAITCSVVAFYIPFLLMVLAYYRIyvtakehaqqIQMLqRAGATSESRPQtadqhsthrmrteTKAA 258
Cdd:cd15161   157 KASRG---------ALVSLAVAFTIPFVTTVTCYLLI----------IRSL-RTGKREEKPLK-------------DKAI 203
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1938531436 259 KTLCVIMGCFCFCWAPFFVTNIVdpFIDYTVPEKVWTA---FLWLG--------YINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15161   204 KMIILVLTIFLICFVPYHISRYI--YILSHNGAGASCSsrrGLALAnritscltCLNGALDPVMYFFVAEKFRETL 277
7tmA_AstC_insect cd15094
somatostatin-like receptor for allatostatin C, member of the class A family of ...
20-323 1.23e-13

somatostatin-like receptor for allatostatin C, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. In Drosophila melanogaster and other insects, a 15-amino-acid peptide named allatostatin C(AstC) binds the somatostatin-like receptors. Two AstC receptors have been identified in Drosophila with strong sequence homology to human somatostatin and opioid receptors.


Pssm-ID: 320222 [Multi-domain]  Cd Length: 282  Bit Score: 70.58  E-value: 1.23e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIkTNYFIVSLAFADLLVsVLVMPFGAIELVQDIWFYGEMFCLVRTSL 99
Cdd:cd15094     1 LISAVLYGLICIVGLVGNGLVIYVVLRYAKMKTV-TNLYILNLAVADECF-LIGLPFLIVTMILKYWPFGAAMCKIYMVL 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 100 DVLLTTASIFHLCCISLDRYYAICcQPLVYRNKMTPLrIALMLGGCWVIPMFISFLPIM---QGWNNIGIV--DVIEKRK 174
Cdd:cd15094    79 TSINQFTSSFTLTVMSADRYLAVC-HPIRSMRYRTPF-IAKVVCATTWSISFLVMLPIIlyaSTVPDSGRYscTIVWPDS 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 175 FNHNSNSTFCVfmvnkpYAITcsvVAFYIPFLLMVLAYYRIyvtakehaqqIQMLQRAGATSESRpqtadqhstHRMRTE 254
Cdd:cd15094   157 SAVNGQKAFTL------YTFL---LGFAIPLLLISVFYTLV----------ILRLRTVGPKNKSK---------EKRRSH 208
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1938531436 255 TKAAKTLCVIMGCFCFCWAPFFVTNIVDPFIDYTVPEKVWTAFLW-----LGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15094   209 RKVTRLVLTVISVYIICWLPYWAFQVHLIFLPPGTDMPKWEILMFllltvLSYANSMVNPLLYAFLSENFRKSF 282
7tmA_S1PR4_Edg6 cd15349
sphingosine-1-phosphate receptor subtype 4 (S1PR4 or S1P4), also called endothelial ...
34-322 1.58e-13

sphingosine-1-phosphate receptor subtype 4 (S1PR4 or S1P4), also called endothelial differentiation gene 6 (Edg6), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320471 [Multi-domain]  Cd Length: 271  Bit Score: 70.20  E-value: 1.58e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  34 ILGNLLVMVAVCRDRQLRKIkTNYFIVSLAFADLL------VSVLVMPFGAIELVQDIWFYGEmfclvrtslDVLLTT-- 105
Cdd:cd15349    15 ILENLLVLLAILRRVRLRRW-VYICLANIALSDLLtgtsylVNICLSGERTFRLTPALWFLRE---------GLLFTAla 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 106 ASIFHLCCISLDRYyAICCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMqGWNNIGIVDviekrkfnhnSNSTFcV 185
Cdd:cd15349    85 ASTFSLLVTAVERY-ATMVRPVAENTATKTYRVYGMIVLCWILAFLIGFLPLL-GWNCLCDFR----------SCSSL-L 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 186 FMVNKPYAITCsVVAFYIPFLLMVLAYYRIYVTAKEHAQQIQmlqragatsesrpqtadqhSTHRMRTETKAAKTLCVIM 265
Cdd:cd15349   152 PLYSKSYILFC-LVIFFIILLTIIGLYFAIYCLVRASGQRVI-------------------SARSRRRSLRLLKTVLMIL 211
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 266 GCFCFCWAPFFVTNIVDpFIDYTVPEKVWTAFLW---LGYINSGLNPFLYAFLNKSFRRA 322
Cdd:cd15349   212 GAFMVCWGPLFILLLVD-FFCSSRSCKPLFGMEWvlaLAVLNSAINPLIYSFRSLEVRRA 270
7tmA_AT2R cd15191
type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
25-323 1.84e-13

type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 341341 [Multi-domain]  Cd Length: 285  Bit Score: 70.16  E-value: 1.84e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  25 FFAMVILMAILGNLLVMVAVCRDRQLRKIkTNYFIVSLAFADLLVsVLVMPFGAIELVQDI-WFYGEMFCLVRTSLDVLL 103
Cdd:cd15191     6 LYSIIFILGFLGNSLVVCVFCHQSGPKTV-ASIYIFNLAVADLLF-LATLPLWATYYSYGYnWLFGSVMCKICGSLLTLN 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 104 TTASIFHLCCISLDRYYAIcCQPLVYRNKmTPLRIALMLGGCWVIPMFIS----FLPIMQGWNNIGIVDVIekRKFNHNS 179
Cdd:cd15191    84 LFASIFFITCMSVDRYLAV-VYPLRSQRR-RSWQARLVCLLVWVLACLSSlptfYFRDTYYIEELGVNACI--MAFPNEK 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 180 NSTFCVFMvnkpyAITCSVVAFYIPFLLMVLAYYRIyvtakehaqqiqmlqragatseSRPQTADQHSTHRMRTETKAAK 259
Cdd:cd15191   160 YAQWSAGL-----ALMKNTLGFLIPLIVIATCYFGI----------------------GRHLLKTKGFGKNKQRRDKVLK 212
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1938531436 260 TLCVIMGCFCFCWAPFFVTNIVDPFIDY---------TVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15191   213 MVAAVVLAFLICWFPFHVLTFLDALARMgvinncwviTVIDKALPFAICLGFSNSCINPFLYCFVGNHFREKL 285
7tmA_SREB3_GPR173 cd15217
super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of ...
21-321 2.69e-13

super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320345 [Multi-domain]  Cd Length: 329  Bit Score: 69.98  E-value: 2.69e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  21 VLLTFFAMVILMAILGNLLVMVAVCRDRQLRKiKTNYFIVSLAFADLLVSVLVMPFGAIELVQ-DIWFYGEMFCLVRTSL 99
Cdd:cd15217     2 VKLVLLGLIICVSLAGNLIVSLLVLKDRALHK-APYYFLLDLCLADTIRSAVCFPFVLVSIRNgSAWTYSVLSCKIVAFM 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 100 DVLLTTASIFHLCCISLDRYYAICCQPLvYRNKMTPLRIALMLGGCWVIPMFISFLPIMqgwnNIGIVDVI--------E 171
Cdd:cd15217    81 AVLFCFHAAFMLFCISVTRYMAIAHHRF-YSKRMTFWTCIAVICMVWTLSVAMAFPPVF----DVGTYKFIreedqcifE 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 172 KRKFNHNSNSTFCVFMvnkpyaiTCSVVAFYIPFLLMVLAYYRiyvtaKEHAQQIQML---------QRAGATSES---- 238
Cdd:cd15217   156 HRYFKANDTLGFMLML-------AVLIVATHIVYGKLLLFEYR-----HRKMKPVQMVpaisqnwtfHGPGATGQAaanw 223
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 239 --------RPQT-----ADQHSTHR-------MRTETKAAKTLCVIMGCFCFCWAPFFVTNIVDPFIDY-TVPEKVWTAF 297
Cdd:cd15217   224 iagfgrgpMPPTllgirQNAHTANRrllgmeeFKAEKRLGRMFYVITLSFLVLWSPYIVACYWRVFVKAcSIPHRYLSTA 303
                         330       340
                  ....*....|....*....|....
gi 1938531436 298 LWLGYINSGLNPFLYAFLNKSFRR 321
Cdd:cd15217   304 VWMSFAQAGVNPIVCFLLNKDLKK 327
7tmA_V1bR cd15386
vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
27-316 2.98e-13

vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; The V1b receptor is specifically expressed in corticotropes of the anterior pituitary and plays a critical role in regulating the activity of hypothalamic-pituitary-adrenal axis, a key part of the neuroendocrine system that controls reactions to stress, by maintaining adrenocorticotropic hormone (ACTH) and corticosterone levels. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320508 [Multi-domain]  Cd Length: 302  Bit Score: 69.83  E-value: 2.98e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  27 AMVILMAILGNLLVMVAVCRDRQLRKiKTNYFIVSLAFADLLVSVL-VMPfgaielvQDIW-----FYG-EMFCLVRTSL 99
Cdd:cd15386     8 AAILVVATAGNLAVLLAMYRMRRKMS-RMHLFVLHLALTDLVVALFqVLP-------QLIWeityrFQGpDLLCRAVKYL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 100 DVLLTTASIFHLCCISLDRYYAIcCQPLvyRNKMTPLRIA-LMLGGCWVIP-------MFI-SFLPIMQGwnnIGIVDVI 170
Cdd:cd15386    80 QVLSMFASTYMLIMMTVDRYIAV-CHPL--RTLQQPSRQAyLMIGATWLLScilslpqVFIfSLREVDQG---SGVLDCW 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 171 EKRKFNHNSnstfcvfmvnKPYAITCSVVAFYIPFLLMVLAY----YRIYVTAKEHAQQIQMLQRAGATS--ESRPQTAD 244
Cdd:cd15386   154 ADFGFPWGA----------KAYITWTTLSIFVLPVAILIVCYslicYEICKNLKGKTQTSRSEGGGWRTQgmPSRVSSVR 223
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1938531436 245 QHSTHRMRTetkaAKTLCVIMGCFCFCWAPFFVTNIVDPFiDYTVPEK-----VWTAFLWLGYINSGLNPFLYAFLN 316
Cdd:cd15386   224 TISRAKIRT----VKMTFVIVLAYIACWAPFFSVQMWSVW-DENAPDEdssdfAFTITMLLASLSSCCNPWIYMFFS 295
7tmA_NPFFR1 cd15981
neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G ...
20-323 4.71e-13

neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320647 [Multi-domain]  Cd Length: 299  Bit Score: 69.08  E-value: 4.71e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIkTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSL 99
Cdd:cd15981     1 AMFILAYLFIFLLCMVGNGLVCFIVLKNRQMRTV-TNMFILNLAVSDLLVGIFCMPTTLVDNLITGWPFDNAMCKMSGLV 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 100 DVLLTTASIFHLCCISLDRYYAICCQplvYRNKMTPLRIALMLGGCWVIPmfisfLPIMQGWNNIGIVDVIEKRKFNHNS 179
Cdd:cd15981    80 QGMSVSASVFTLVAIAVERFRCIVHP---FRQKLTLRKAIVTIVIIWVLA-----LIIMCPSAVTLTVTREEHHFMVDDY 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 180 NSTFCVFM---------VNKPYAITCSVVAFYIPFLLMVLAYYRIyvtakehaqQIQMLQRAGATSESRPQTADQHSTHR 250
Cdd:cd15981   152 NNSYPLYScweawpdteMRKIYTTVLFSHIYLAPLTLIVIMYARI---------AFKLFKSSAPIRGSQGEEEEGRRVSK 222
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1938531436 251 MRteTKAAKTLCVIMGCFCFCWAPFFVTNIVDPFIDYTVPE------KVWTAFLWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15981   223 RK--IKVINMLIIVALFFTLSWLPLWTLMLLTDYGHLSEDQlnlvtvYVFPFAHWLAFFNSSVNPIIYGYFNENFRRGF 299
7tmA_CCR7 cd15175
CC chemokine receptor type 7, member of the class A family of seven-transmembrane G ...
22-218 5.56e-13

CC chemokine receptor type 7, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR7 is a major homeostatic receptor responsible for lymph node development and effective adaptive immune responses and plays a critical role in trafficking of dendritic cells and B and T lymphocytes. Its only two ligands, CCL and CCl21, are primarily produced by stromal cells in the T cell zones of lymph nodes and spleen. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341331 [Multi-domain]  Cd Length: 278  Bit Score: 68.64  E-value: 5.56e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  22 LLTFFAMVILMAILGNLLVMVAVCRDRQLrKIKTNYFIVSLAFADLLVsVLVMPFGAIElVQDIWFYGEMFCLVRTSLDV 101
Cdd:cd15175     3 LPAMYSVICFLGLLGNGLVILTYIYFKRL-KTMTDIYLLNLALADILF-LLTLPFWAAS-AAKKWVFGEEMCKAVYCLYK 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 102 LLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIA-LMLGGCWVIPMFISfLPIMQgWNNIGIVDVIEKRKFNHNSN 180
Cdd:cd15175    80 MSFFSGMLLLMCISIDRYFAIVQAASAHRHRSRAVFISkVSSLGVWVLAFILS-IPELL-YSGVNNNDGNGTCSIFTNNK 157
                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1938531436 181 STFCVFMVnkpyaITCSVVAFYIPFLLMVLAYYRIYVT 218
Cdd:cd15175   158 QTLSVKIQ-----ISQMVLGFLVPLVVMSFCYSVIIKT 190
7tmA_P2Y1-like cd15168
P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of ...
25-323 7.44e-13

P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y1-like receptors as well as other closely related orphan receptors, such as GPR91 (a succinate receptor) and GPR80/GPR99 (an alpha-ketoglutarate receptor).


Pssm-ID: 341329 [Multi-domain]  Cd Length: 284  Bit Score: 68.11  E-value: 7.44e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  25 FFAMVILMAILGNLLVMVAVCRdrQLRKIK-TNYFIVSLAFADLLVsVLVMPFGAIELVQ-DIWFYGEMFC-LVRTSLDV 101
Cdd:cd15168     6 VYGVVFLVGLLLNSVVLYRFIF--HLKPWNsSAIYMFNLAVSDLLY-LLSLPFLIYYYANgDHWIFGDFMCkLVRFLFYF 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 102 LLTTaSIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVIpMFISFLPIMqgwnnigivdviekrKFNHNSNS 181
Cdd:cd15168    83 NLYG-SILFLTCISVHRYLGI-CHPLRSLGKLKKRHAVAISVAVWIL-VLLQLLPIL---------------FFATTGRK 144
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 182 TFCV----------FMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAQQiqmlqraGATSESRpqtadqhsthrm 251
Cdd:cd15168   145 NNRTtcydttspeeLNDYVIYSMVLTGLGFLLPLLIILACYGLIVRALIRKLGE-------GVTSALR------------ 205
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 252 rteTKAAKTLCVIMGCFCFCWAPFFVTNIVdpFIDYTVPEKVWTAFL----WLGYI--------NSGLNPFLYAFLNKSF 319
Cdd:cd15168   206 ---RKSIRLVIIVLALFAVCFLPFHVTRTI--NLAARLLSGTASCATlngiYVAYKvtrplaslNSCLNPLLYFLAGDKF 280

                  ....
gi 1938531436 320 RRAF 323
Cdd:cd15168   281 RRRL 284
7tmA_NTSR2 cd15356
neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G ...
20-323 7.53e-13

neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320478 [Multi-domain]  Cd Length: 285  Bit Score: 68.35  E-value: 7.53e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIKT--NYFIVSLAFADLLVSVLVMPfgaIELVQDIWF-----YGEMF 92
Cdd:cd15356     1 VLFTAVYALIWALGAAGNALTIHLVLKKRSLRGLQGtvHYHLVSLALSDLLILLISVP---IELYNFVWFhypwvFGDLV 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  93 CLVRTSLDVLLTTASIFHLCCISLDRYYAICcQPLVYRNKMTPLRIALMLGGCWVIPMFISfLP---IMqgwnniGIVDV 169
Cdd:cd15356    78 CRGYYFVRDICSYATVLNIASLSAERYLAIC-QPLRAKRLLSKRRTKWLLALIWASSLGFA-LPmafIM------GQKYE 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 170 IEKRKFNHNSNSTFCVFMVNKPYAITCSVVAFYIPFLL-MVLAYYRIYVTAKEhaQQIQMLQragatsesrpqtadqHST 248
Cdd:cd15356   150 LETADGEPEPSSRVCTVLVSRATLKVFIQVNAFVSFVLpLALIAFLNGVTVSH--LRIQSLQ---------------HSV 212
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 249 HRMRTetkaaktlCVIMgcFCFCWAPFFVTNIVDPFidytVPEKVWTAFLW------------LGYINSGLNPFLYAFLN 316
Cdd:cd15356   213 QVLRA--------IVIA--YVICWLPYHARRLMFCY----VPDDAWTDSLYnfyhyfymltntLFYVSSAVNPLLYNVVS 278

                  ....*..
gi 1938531436 317 KSFRRAF 323
Cdd:cd15356   279 SSFRKLF 285
7tmA_GPR151 cd15002
G protein-coupled receptor 151, member of the class A family of seven-transmembrane G ...
21-323 1.36e-12

G protein-coupled receptor 151, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 151 (GRP151) is an orphan receptor of unknown function. Its expression is conserved in habenular axonal projections of vertebrates and may be a promising novel target for psychiatric drug development. GPR151 shows high sequence similarity with galanin receptors (GALR). GPR151 is a member of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320133 [Multi-domain]  Cd Length: 280  Bit Score: 67.44  E-value: 1.36e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  21 VLLTFFAMVILMAILGNLLVMVAVCRDRqlRKIK---TNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRT 97
Cdd:cd15002     1 LVPILLGVICLLGFAGNLMVIGILLNNA--RKGKpslIDSLILNLSAADLLLLLFSVPFRAAAYSKGSWPLGWFVCKTAD 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  98 SLDVLLTTASIFHLCCISLDRYYAIcCQPLVYRNkMTPLRIALMLGGCWVIPmfiSFLPIMQgWNNIGIVdviekrkfnH 177
Cdd:cd15002    79 WFGHACMAAKSFTIAVLAKACYMYV-VNPTKQVT-IKQRRITAVVASIWVPA---CLLPLPQ-WLFRTVK---------Q 143
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 178 NSNSTFCVFMVNKP-------YAITCSVVAFYIPFLLMVLAYYRIYvtakehaqqiQMLQRAGatsesrpqTADQHSTHR 250
Cdd:cd15002   144 SEGVYLCILCIPPLahefmsaFVKLYPLFVFCLPLTFALFYFWRAY----------GQCQRRG--------TKTQNLRNQ 205
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 251 MRTEtKAAKTLCVIMGCFCFCWAPffvtnivdpfidytvpekVWTAFLWLGYI---------------------NSGLNP 309
Cdd:cd15002   206 IRSR-KLTHMLLSVVLAFTILWLP------------------EWVAWLWLIHIkssgssppqlfnvlaqllafsISSVNP 266
                         330
                  ....*....|....
gi 1938531436 310 FLYAFLNKSFRRAF 323
Cdd:cd15002   267 IIFLLMSEEFREGF 280
7tmA_ACKR2_D6 cd15188
atypical chemokine receptor 2, member of the class A family of seven-transmembrane G ...
20-320 3.12e-12

atypical chemokine receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR2 (also known as D6) binds non-selectively to all inflammatory CC-chemokines, but not to homeostatic CC-chemokines involved in controlling the migration of cells. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320316 [Multi-domain]  Cd Length: 278  Bit Score: 66.35  E-value: 3.12e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIKTNYFIVSLAFADLLVsVLVMPFGAIELVQDiWFYGEMFCLVRTSL 99
Cdd:cd15188     1 VFLPVFYTLVFLLGLAGNLLLFVVLLLYVPKKKKMTEVYLLNLAVSDLLF-LVTLPFWAMYVAWH-WVFGSFLCKFVSTL 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 100 DVLLTTASIFHLCCISLDRYYAIC-CQPlvYRNKMTPLRIALMLGGCWVIPMFIS---FLPIMQGWNNIGIVDVIEKRKF 175
Cdd:cd15188    79 YTINFYSGIFFVSCMSLDKYLEIVhAQS--PHRLRTRRKSLLVLVAVWVLSIALSvpdMVFVQTHHTNNGVWVCHADYGG 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 176 NHNSNSTFCVFMVNkpyaitcsVVAFYIPFLLMVLAYYRIyvtakehaqqiqmlqragatsesrpqtADQHSTHRMRTET 255
Cdd:cd15188   157 HHTIWKLVFQFQQN--------LLGFLFPLLAMVFFYSRI---------------------------ACVLTRLRPPGQG 201
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1938531436 256 KAAKTLCVIMGCFCFCWAPFFVTNIVDPFIDYTVPEKVWTAFLW---------LGYINSGLNPFLYAFLNKSFR 320
Cdd:cd15188   202 RALRFVAALVVVFFVLWFPYNLTLFLHSLQDLHVIGNCERSRHLdyalqvtesLAFVHCCLNPLLYAFVSKRFR 275
7tmA_LTB4R cd14975
leukotriene B4 receptors, member of the class A family of seven-transmembrane G ...
20-314 4.15e-12

leukotriene B4 receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the G(q)-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320106 [Multi-domain]  Cd Length: 278  Bit Score: 65.97  E-value: 4.15e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIkTNYFIVSLAFADLLVsVLVMPFGAIELVQDIWFYGEMFCLVRTSL 99
Cdd:cd14975     1 VLGCTLLSLAFAIGLPGNSFVIWSILIKVKQRSV-TMLLVLNLALADLAV-LLTLPVWIYFLATGTWDFGLAACKGCVYV 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 100 DVLLTTASIFHLCCISLDRYYAICcQPLV---YRNKMTPLRIALMLggcWVIPMFISfLPIMqGWNNIGIVDVIEKRKFN 176
Cdd:cd14975    79 CAVSMYASVFLITLMSLERFLAVS-RPFVsqgWRAKALAHKVLAII---WLLAVLLA-TPVI-AFRHVEETVENGMCKYR 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 177 HNSNS--TFCVFMVnkpyaitcSVVAFYIPFLLMVLAYYRIYVtakehaqqiqmlqRAGATsesrpqtadqhsthRMRTE 254
Cdd:cd14975   153 HYSDGqlVFHLLLE--------TVVGFAVPFTAVVLCYSCLLR-------------RLRRR--------------RFRRR 197
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1938531436 255 TKAAKTLCVIMGCFCFCWAPFFVTNIVDPFIDYTVP-------EKVWTAFLW----LGYINSGLNPFLYAF 314
Cdd:cd14975   198 RRTGRLIASVVVAFAACWLPYHVGNLLEVVSELIGGskmagtlGKVAEAGRPiagaLAFLSSSINPLLYAF 268
7tmA_BNGR-A34-like cd15000
putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of ...
23-323 4.85e-12

putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor BNGR-A34 found in silkworm and its closely related proteins from invertebrates. They are members of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320131 [Multi-domain]  Cd Length: 285  Bit Score: 65.91  E-value: 4.85e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  23 LTFFAMVILMAILGNLLVMVAVCRDRQLRKiKTNYFIVSLAFADLLvSVLVMPfgAIELVQDI---WFYGEMFCLVRTSL 99
Cdd:cd15000     3 SSMFLPVVLFGIFGNFVLLYILASNRSLRT-PTNLLIGNMALADLL-TLLVCP--WMFLVHDFfqnYVLGSVGCKLEGFL 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 100 DVLLTTASIFHLCCISLDRYYAICcqpLVYRNKMTPLRIALMLGGCWVIPMFISfLPImqgwnniGIVDVIEKRKFNhNS 179
Cdd:cd15000    79 EGSLLLASVLALCAVSYDRLTAIV---LPSEARLTKRGAKIVIVITWIVGLLLA-LPL-------AIYRSYRERQWK-NF 146
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 180 NSTFCV--FMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVtakehaqQIQMLQRAGATSESRpqtadqhstHRMRTETKA 257
Cdd:cd15000   147 LETYCAenTQVLPIYWHVIITVLVWLPLGIMLICYSAIFW-------KLDKYERRVLRREHP---------SVVRYKKKA 210
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 258 AKTLCVIMGCFCFCWAPF--------------FVTNIVDPFIdytvpEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15000   211 AKTLFIVLITFVVCRIPFtalifyryklvpndNTQNSVSGSF-----HILWFASKYLMFLNAAVNPLIYGFTNENFRKAF 285
7tmA_GPR88-like cd15211
G protein-coupled receptor 88, member of the class A family of seven-transmembrane G ...
22-323 5.19e-12

G protein-coupled receptor 88, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR88, an orphan G protein-coupled receptor, is predominantly and almost exclusively expressed within medium spiny neurons (MSNs) of the brain's striatum in both human and rodents; thus it is also called Striatum-specific GPCR (STRG). The striatum is known to involve in motor coordination, reward-based decision making, and response learning. GPR88 is shown to co-localize with both dopamine D1 and D2 receptors and displays the highest sequence similarity to receptors for biogenic amines such as dopamine and serotonin. GPR88 knockout mice showed abnormal behaviors observed in schizophrenia, such as disrupted sensorimotor gating, increased stereotypic behavior and locomotor activity in response to treatment with dopaminergic compounds such as apomorphine and amphetamine, respectively, suggesting a role for GPR88 in dopaminergic signaling. Furthermore, the transcriptional profiling studies showed that GPR88 expression is altered in a number of psychiatric disorders such as depression, drug addiction, bipolar and schizophrenia, providing further evidence that GPR88 plays an important role in CNS signaling pathways related to psychiatric disorder. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320339 [Multi-domain]  Cd Length: 283  Bit Score: 65.64  E-value: 5.19e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  22 LLTFFAMVILMAILGNLLVMVAVCRDRQLRKiKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEmFCLVRTSLDV 101
Cdd:cd15211     2 LSTVYSFLAVSGTLANVLVIYLVVSFKKLQT-TSNAFIVNGCVADLLVCAFWMPQEAVLGSTGTLLVLG-YRLFREGLLF 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 102 LLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVIPMfiSFLPIMQGWNNIGivdviEKRKFNHNSNS 181
Cdd:cd15211    80 LGLTVSLLSHSLIALNRYVLITKLPAVYQALYQKRNTEWMIALSWALAL--GLLLPWLTSFRYP-----TKSCHDSADGS 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 182 TFCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAQQIQMLQragatseSRPQTADQHSTHRMRTETkaakTL 261
Cdd:cd15211   153 FAVVSVLSSRYPALLLAFTVLGQTALVLHCYFGIFRRVQISVKRVSVLN-------FQIVNNLPYSRPRKDKRL----GL 221
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1938531436 262 CVIMGCFCFCWA--PFFVTNIVDPFIdyTVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15211   222 YVLLVCCVFLLTtePLVWVSLAGLFV--PVPVALQTASWLLFCTLFVLNPFLYTWKNEEFRRSF 283
7tmA_RNL3R cd14976
relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G ...
26-323 5.34e-12

relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This G protein-coupled receptor subfamily is composed of the relaxin-3 like peptide receptors, RNL3R1 and RNL3R2, and similar proteins. The relaxin-3 like peptide family includes relaxin-1, -2, -3, as well as insulin-like (INSL) peptides 3 to 6. RNL3/relaxin-3 and INSL5 are the endogenous ligands for RNL3R1 and RNL3R2, respectively. RNL3R1, also called GPCR135 or RXFP3, is predominantly expressed in the brain and is implicated in stress, anxiety, feeding, and metabolism. Insulin-like peptide 5 (INSL5), the endogenous ligand for RNL3R2 (also called GPCR142 or RXFP4), plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. Both RNL3R1 and RNL3R2 signal through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation. RNL3R1 is shown to activate Erk1/2 signaling pathway.


Pssm-ID: 320107 [Multi-domain]  Cd Length: 290  Bit Score: 65.99  E-value: 5.34e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  26 FAMVILMAILGNLLVMVAVCRDRQLRKIKT-NYFIVSLAFADLLVsVLVMPFGAIELVQD-IWFYGEMFCLVRTSLDVLL 103
Cdd:cd14976     7 YMVVFTVGLLGNLLVLYLLKSNKKLRQQSEsNKFVFNLALTDLIF-VLTLPFWAVEYALDfVWPFGTAMCKVVRYVTKLN 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 104 TTASIFHLCCISLDRYYAICcqplvyrNKMTPLRIaLMLGGCWVIPMFISFLPIM----------QGWNNIGivDVIEKR 173
Cdd:cd14976    86 MYSSIFFLTALSVTRYIAVA-------RALKHGWI-RKAFGAFATTIAIWAAAALaaipeaifstDTWSSVN--HTLCLL 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 174 KFNHNSNSTFCVFMVNKpYAITCSVVAFYIPFLLMVLAYYRIyvtakehaqqIQMLQRagatsesrpqtadqHSTHRMRT 253
Cdd:cd14976   156 RFPKNSSVTRWYNWLGM-YQLQKVVLGFFLPLGIITLSYLLL----------LRFLQR--------------KRGGSKRR 210
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 254 ETKAAKTLCVIMGCFCFCWAPFFVT---------NIVdPFID--YTVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRA 322
Cdd:cd14976   211 KSRVTKSVFIVVLSFFICWLPNQALslwsalikfDDV-PFSDafFAFQTYAFPVAICLAHSNSCLNPVLYCLVRREFRDA 289

                  .
gi 1938531436 323 F 323
Cdd:cd14976   290 L 290
7tmA_NPY6R cd15396
neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G ...
21-321 5.55e-12

neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320518 [Multi-domain]  Cd Length: 293  Bit Score: 66.01  E-value: 5.55e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  21 VLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIkTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSLD 100
Cdd:cd15396     2 LLIIAYSVVTIVGLFGNLCLITIIKKQKEEHNV-TNILIANLSLSDVLVCVMCIPFTAVYTLMDHWIFGETMCKLTSFVQ 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 101 VLLTTASIFHLCCISLDRYYAICcQPLVYRNKMTPLRIALMLggCWVIPMFISFlPIMqgwnnigIVDVIEKRKFNHNS- 179
Cdd:cd15396    81 SVSVSVSIFSLVLIAIERYQLIV-NPRGWKPSASHAYWGIVL--IWLFSLMISI-PFL-------IFHQLTDEPFRNLSs 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 180 ------NSTFCV----FMVNKPYAITCSVV-AFYIPFLLMVLAYYRIYVTAKEHAQQIQMLQRagatSESRpqtadqhst 248
Cdd:cd15396   150 hsdfykDKVVCIeawpSETERLIFTTSLLVfQYFVPLGFIFICYLKIFVCLKKRNSKIDRMRE----NESR--------- 216
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1938531436 249 hrmRTETKAAKTLCV-IMGCFCFCWAPFFVTNIVDPFIDYTV----PEKVWTAFLWLGYINSGLNPFLYAFLNKSFRR 321
Cdd:cd15396   217 ---LSENKRINTMLIsIVVTFAACWLPLNIFNVVFDWNHEVLmschHNLVFTLCHLVAMVSTCINPIFYGFLNKNFQK 291
7tmA_ACKR4_CCR11 cd15176
atypical chemokine receptor 4, member of the class A family of seven-transmembrane G ...
20-218 7.42e-12

atypical chemokine receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR4 was first reported to bind several CC chemokines including CCL19, CCL21, and CCL25 and was originally designated CCR11. AKCR4 is unable to couple to G-protein and, instead, it preferentially mediates beta-arrestin dependent processes, such as receptor internalization, after ligand binding. Thus, ACKR4 may act as a scavenger receptor to suppress the effects of proinflammatory chemokines. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320304 [Multi-domain]  Cd Length: 276  Bit Score: 65.15  E-value: 7.42e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVmVAVCRDRQLRKIKTNYFIVSLAFADLLVsVLVMPFGAIELVQDiWFYGEMFCLVRTSL 99
Cdd:cd15176     1 LFLPVFYTIALVVGLAGNSLV-VAIYAYYKKLKTKTDVYILNLAVADLLL-LFTLPFWAADAVNG-WVLGTAMCKITSAL 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 100 DVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTplrialmlggCWVIPMFISFLPIMqgwnnIGIVDVI-EKRKFNHN 178
Cdd:cd15176    78 YTMNFSCGMQFLACISVDRYVAITKATSRQFTGKH----------CWIVCLCVWLLAIL-----LSIPDLVfSTVRENSD 142
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1938531436 179 SNSTFCVFMVNKPYAITCSV------VAFYIPFLLMVLAYYRIYVT 218
Cdd:cd15176   143 RYRCLPVFPPSLVTSAKATIqilevlLGFVLPFLVMVFCYSRVARA 188
7tmA_CXCR4 cd15179
CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G ...
20-320 8.97e-12

CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR4 is the only known G protein-coupled chemokine receptor for the key homeostatic ligand CXCL12, which is constitutively secreted by bone marrow stromal cells. Atypical chemokine receptor CXCR7 (ACKR3) also binds CXCL12, but activates signaling in a G protein-independent manner. CXCR4 is also a co-receptor for HIV infection and plays critical roles in the development of immune system during both lymphopoiesis and myelopoiesis. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341334 [Multi-domain]  Cd Length: 278  Bit Score: 65.17  E-value: 8.97e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIkTNYFIVSLAFADLLVsVLVMPFGAIELVQDiWFYGEMFCLVRTSL 99
Cdd:cd15179     1 IFLPTVYSIIFLLGIVGNGLVILVMGYQKKSRTM-TDKYRLHLSVADLLF-VLTLPFWAVDAAAN-WYFGNFLCKAVHVI 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 100 DVLLTTASIFHLCCISLDRYYAIccqplVYRNKMTPLRIAL----MLGGCWVIPMFISFLPIMQGWNNIGIVDVIEKRKF 175
Cdd:cd15179    78 YTVNLYSSVLILAFISLDRYLAI-----VHATNSQRPRKLLaekvVYVGVWLPALLLTVPDLVFAKVSELDDRYICDRIY 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 176 NHNSNSTFCVfmvnkPYAITCSVVAFYIPFLLMVLAYYRIYvtakehaqqiqmlqragatsesrpQTADQHSTHRMRtet 255
Cdd:cd15179   153 PEDTFELWVV-----AFRFQHILVGLVLPGLVILTCYCIII------------------------SKLSHSKGHQKR--- 200
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1938531436 256 KAAKTLCVIMGCFCFCWAPFFVTNIVDPFIDYTVPEK---------VWTAFL-WLGYINSGLNPFLYAFLNKSFR 320
Cdd:cd15179   201 KALKTTVILILAFFACWLPYYIGISIDTFMLLEIIKQscemeqtvhKWISITeALAFFHCCLNPILYAFLGAKFK 275
7tmA_MC4R cd15353
melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G ...
26-323 1.41e-11

melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320475 [Multi-domain]  Cd Length: 269  Bit Score: 64.16  E-value: 1.41e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  26 FAMVILMAILGNLLVMVAVCRDRQLRKiKTNYFIVSLAFADLLVSV------LVMPFGAIELVQDIWFYGEMFCLVRTSL 99
Cdd:cd15353     7 FVTLGIVSLLENILVIAAIAKNKNLHS-PMYFFICSLAVADMLVSVsngsetVVITLLNGNDTDAQSFTVNIDNVIDSVI 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 100 DVLLTtASIFHLCCISLDRYYAICcQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMQgwnnigivdviekrkfnhnS 179
Cdd:cd15353    86 CSSLL-ASICSLLSIAVDRYFTIF-YALQYHNIMTVRRAGVIITCIWTACTVSGVLFIIY-------------------S 144
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 180 NSTFcvfmvnkpyAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAQQIQMLQRAGATsesrpqtadqhsthRMRTETKAAK 259
Cdd:cd15353   145 DSSV---------VIICLISMFFTMLALMASLYVHMFLLARLHIKRIAVLPGTGPI--------------RQGANMKGAI 201
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1938531436 260 TLCVIMGCFCFCWAPFF---VTNIVDPFIDYTVP-EKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15353   202 TLTILLGVFVVCWAPFFlhlIFYISCPRNPYCVCfMSHFNMYLILIMCNSVIDPLIYAFRSQELRKTF 269
7tmA_MC2R_ACTH_R cd15350
melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of ...
26-323 1.43e-11

melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320472 [Multi-domain]  Cd Length: 270  Bit Score: 64.42  E-value: 1.43e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  26 FAMVILMAILGNLLVMVAVCRDRQLRkIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRT------SL 99
Cdd:cd15350     7 FFTIAAVGLLENLLVLVAVIKNKNLH-SPMYFFICSLAVSDMLGSLYKTLENILIILADMGYLNRRGPFETKlddimdSL 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 100 DVLLTTASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVipmfisflpimqgwnnigivdviekrkFNHNS 179
Cdd:cd15350    86 FCLSLLGSIFSILAIAADRYITI-FHALRYHNIMTMRRTLVILAIIWT---------------------------FCGGS 137
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 180 NSTFCVFMVNKPYAItCSVVAFYIPFLLMVLAYYRIYVTAKEHAQQIQMLQragatsesrpqtadQHSTHRMRTETKAAK 259
Cdd:cd15350   138 GILMILFFHFVATVI-CFTVLFFLMLVLILCLYVHMFLLARSHARKIASLP--------------NHHAQHQRSNMRGAI 202
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1938531436 260 TLCVIMGCFCFCWAPFFVTNIVDPFIDYTVPEKVWTAFLWLGYI----NSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15350   203 TLTILLGVFVCCWAPFVLHLLLMMFCPMNPYCACYRSLFQVNGTlimsHAVIDPAIYAFRSPELRNTF 270
7tmA_FPR-like cd15117
N-formyl peptide receptors, member of the class A family of seven-transmembrane G ...
23-323 1.60e-11

N-formyl peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed at elevated levels on polymorphonuclear and mononuclear phagocytes. FPRs bind N-formyl peptides, which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Activation of FPRs by N-formyl peptides such as N-formyl-Met-Leu-Phe (FMLP) triggers a signaling cascade that stimulates neutrophil accumulation, phagocytosis and superoxide production. These responses are mediated through a pertussis toxin-sensitive G(i) protein that activates a PLC-IP3-calcium signaling pathway. While FPRs are involved in host defense responses to bacterial infection, they can also suppress the immune system under certain conditions. Yet, the physiological role of the FPR family is not fully understood.


Pssm-ID: 320245 [Multi-domain]  Cd Length: 288  Bit Score: 64.37  E-value: 1.60e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  23 LTFFAMVILMAILGNLLVmVAVCRDRQLRKIKTNYFIvSLAFADLLVSvLVMPFGAIELVQDI-WFYGEMFCLVRTSLDV 101
Cdd:cd15117     4 LVIYSSAFVLGTLGNGLV-IWVTGFRMTRTVTTVCFL-NLAVADFAFC-LFLPFSVVYTALGFhWPFGWFLCKLYSTLVV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 102 LLTTASIFHLCCISLDRyyAICC-QPLVYRNKMTPLRIALMLGGCWVIPMFISFlpimqgwnnigivDVIEKRKFNHNSN 180
Cdd:cd15117    81 FNLFASVFLLTLISLDR--CVSVlWPVWARNHRTPARAALVAVGAWLLALALSG-------------PHLVFRDTRKENG 145
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 181 STFCVFMVNKP--------------------YAITCSVVAFYIPFLLMVLAYYRIyvTAKehaqqiqmLQRAGATSESRP 240
Cdd:cd15117   146 CTHCYLNFDPWnetaedpvlwletvvqrlsaQVITRFVLGFLVPLVIIGGCYGLI--AAR--------LWREGWVHSSRP 215
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 241 QtadqhsthrmrtetkaaKTLCVIMGCFCFCWAPFFVTNIVD-------PFIDYTVPEKVWTAFLWLGYINSGLNPFLYA 313
Cdd:cd15117   216 F-----------------RVLTAVVAAFFLCWFPFHLVSLLElvvilnqKEDLNPLLILLLPLSSSLACVNSCLNPLLYV 278
                         330
                  ....*....|
gi 1938531436 314 FLNKSFRRAF 323
Cdd:cd15117   279 FVGRDFRERL 288
7tmA_motilin_R cd15132
motilin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
20-322 1.90e-11

motilin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Motilin receptor, also known as GPR38, is a G-protein coupled receptor that binds the endogenous ligand motilin. Motilin is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. Motilin is also called as the housekeeper of the gut because it is responsible for the proper filling and emptying of the gastrointestinal tract in response to food intake, and for stimulating the production of pepsin. Motilin receptor shares significant amino acid sequence identity with the growth hormone secretagogue receptor (GHSR) and neurotensin receptors (NTS-R1 and 2).


Pssm-ID: 320260 [Multi-domain]  Cd Length: 289  Bit Score: 64.05  E-value: 1.90e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMvilmAILGNLLVMVAVCRDRQLRKiKTNYFIVSLAFADLLVsVLVMPFGAIELVQDI-WFYGEMFCLVRTS 98
Cdd:cd15132     5 IVCLILFVV----GVTGNTMTVLIIRRYKDMRT-TTNLYLSSMAVSDLLI-LLCLPFDLYRLWKSRpWIFGEFLCRLYHY 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  99 LDVLLTTASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVIPMfISFLPIMqgwnniGIVDVIEKRKFNHN 178
Cdd:cd15132    79 ISEGCTYATILHITALSIERYLAI-CFPLRAKVLVTRRRVKCVIAALWAFAL-LSAGPFL------FLVGVEQDNNIHPD 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 179 SNSTFCVFmvnKPYAIT---------CSVVAFYIPFLLMVLAYYRIYVTAKEHAQQIQmlqragatsesRPQTADQHSTH 249
Cdd:cd15132   151 DFSRECKH---TPYAVSsgllgimiwVTTTYFFLPMLCLSFLYGFIGRKLWKSKNDLR-----------GPNAAARERSH 216
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1938531436 250 RmrtetKAAKTLCVIMGCFCFCWAPFFVTNIVDPFIDYTVPEKVWTAF----LWLGYINSGLNPFLYAFLNKSFRRA 322
Cdd:cd15132   217 R-----QTVRILAVVVLAFIICWLPFHIGRILFANTEDYRTMMFSQYFnivaMQLFYLSASINPILYNLISRKYRAA 288
7tmA_NTSR cd15130
neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
20-323 2.06e-11

neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320258 [Multi-domain]  Cd Length: 281  Bit Score: 63.81  E-value: 2.06e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIKT--NYFIVSLAFADLLVSVLVMPfgaIELVQDIWF-----YGEMF 92
Cdd:cd15130     1 VLVTAIYLALFVVGTVGNSVTLFTLARKKSLQSLQStvRYHLGSLALSDLLILLLAMP---VELYNFIWVhhpwaFGDAG 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  93 CLVRTSLDVLLTTASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVIPMFISfLPIMQgwnnigIVDVIEK 172
Cdd:cd15130    78 CRGYYFLRDACTYATALNVASLSVERYLAI-CHPFKAKTLMSRSRTKKFISAIWLASALLA-IPMLF------TMGLQNE 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 173 RKFNHNSNSTFCVFMVNKPYAITCSVVAFYIPFLL-MVLAYYRIYVTAKEHAQQIqmlqragatsesrpqtadQHSTHRM 251
Cdd:cd15130   150 SDDGTHPGGLVCTPIVDTATLKVVIQVNTFMSFLFpMLVTSILNTVIANKLVQAL------------------RRGVLVL 211
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 252 RTetkaaktlCVIMgcFCFCWAPFFVTNIVDPFIdytvPEKVWTAFLW------------LGYINSGLNPFLYAFLNKSF 319
Cdd:cd15130   212 RA--------VVIA--FVVCWLPYHVRRLMFCYI----SDEQWTTFLFdfyhyfymltnaLFYVSSAINPILYNLVSANF 277

                  ....
gi 1938531436 320 RRAF 323
Cdd:cd15130   278 RQVF 281
7tmA_LPAR3_Edg7 cd15343
lysophosphatidic acid receptor subtype 3 (LPAR3 or LPA3), also called endothelial ...
20-323 3.38e-11

lysophosphatidic acid receptor subtype 3 (LPAR3 or LPA3), also called endothelial differentiation gene 7 (Edg7), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320465 [Multi-domain]  Cd Length: 274  Bit Score: 63.36  E-value: 3.38e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRkIKTNYFIVSLAFADLLVSV----LVMPFGAI--ELVQDIWFYGEmfC 93
Cdd:cd15343     1 IIVLCVGTFCCLFIFVSNSLVIAAVVKNKRFH-YPFYYLLANLAAADFFAGIayvfLMFNTGPVskTLTVNRWFLRQ--G 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  94 LVRTSLdvlltTASIFHLCCISLDRYYAIccQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMqGWNNIGIVDVIEKr 173
Cdd:cd15343    78 LLDTSL-----SASLTNLLVIAVERHISI--MRMKVHSNLTKRRVTLLIALVWAIAIFMGAVPTL-GWNCICNISACSS- 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 174 kfnhnsnstfCVFMVNKPYAITCSVVAFYIpFLLMVLAYYRIYVTAKEHaqqiqmlqragaTSESRPQTADqhSTHRMRT 253
Cdd:cd15343   149 ----------LAPIYSRSYLVFWSVSNLVV-FLIMVVVYLRIYVYVQRK------------TNVLSPHTSG--SINRRRT 203
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1938531436 254 ETKAAKTLCVIMGCFCFCWAPFFVTNIVDPF-IDYTVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15343   204 PIKLMKTVMTVLGAFVICWTPGLVVLLLDGLnCTRCGVQHVKRWFLLLALLNSVMNPIIYSYKDEEMWGTM 274
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
19-281 3.90e-11

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 63.64  E-value: 3.90e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  19 KVVLLTFFAMVILMAILGNLLVMVAVCRdrqlRKIKT--NYFIVSLAFADLLVsVLVMPFGAIELVQDIWFYGEMFCLVR 96
Cdd:PHA03087   40 STILIVVYSTIFFFGLVGNIIVIYVLTK----TKIKTpmDIYLLNLAVSDLLF-VMTLPFQIYYYILFQWSFGEFACKIV 114
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  97 TSLDVLLTTASIFHLCCISLDRYYAICcQPLVYrNKMTPLRIALMLGGC-WVIPMFISFlPIMqgwnnigIVDVIEK--- 172
Cdd:PHA03087  115 SGLYYIGFYNSMNFITVMSVDRYIAIV-HPVKS-NKINTVKYGYIVSLViWIISIIETT-PIL-------FVYTTKKdhe 184
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 173 ---RKFNHNSNSTFCVFMVNkpyaITCSVVAFYIPFLLMVLAYYRIYVTAKehaqQIQMLQRAgatsesrpqtadqhsth 249
Cdd:PHA03087  185 tliCCMFYNNKTMNWKLFIN----FEINIIGMLIPLTILLYCYSKILITLK----GINKSKKN----------------- 239
                         250       260       270
                  ....*....|....*....|....*....|..
gi 1938531436 250 rmrteTKAAKTLCVIMGCFCFCWAPFFVTNIV 281
Cdd:PHA03087  240 -----KKAIKLVLIIVILFVIFWLPFNVSVFV 266
7tmA_GPR25 cd15193
G protein-coupled receptor 25, member of the class A family of seven-transmembrane G ...
20-321 3.94e-11

G protein-coupled receptor 25, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR25 is an orphan G-protein coupled receptor that shares strong sequence homology to GPR15 and the angiotensin II receptors. These closely related receptors form a group within the class A G-protein coupled receptors (GPCRs). GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation. Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors.


Pssm-ID: 320321 [Multi-domain]  Cd Length: 279  Bit Score: 63.23  E-value: 3.94e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIkTNYFIVSLAFADLlVSVLVMPFGAIELVQ-DIWFYGEMFCLVRTS 98
Cdd:cd15193     1 IYIPILYLIIFFTGLLGNLFVIALMSKRSTTKRL-VDTFVLNLAVADL-VFVLTLPFWAASTALgGQWLFGEGLCKLSSF 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  99 LDVLLTTASIFHLCCISLDRYYAICcQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMqgwnnigivdviekrkFNHN 178
Cdd:cd15193    79 IIAVNRCSSILFLTGMSVDRYLAVV-KLLDSRPLRTRRCALITCCIIWAVSLVLGIPSLV----------------YRNL 141
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 179 SNSTFCV----FMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAQQIQMLQRAgatsesrpqtadQHSTHRMrte 254
Cdd:cd15193   142 INESVCVedssSRFFQGISLATLFLTFVLPLIVILFCYCSILVRLRRHFHGAKRTGRR------------RRNSLRI--- 206
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1938531436 255 tkaaktLCVIMGCFCFCWAPFFVTNIVD---PFIDYTVPEKVWTAFLW-------LGYINSGLNPFLYAFLNKSFRR 321
Cdd:cd15193   207 ------VFAIVTAFVLSWLPFNTLKAVRlllELGGGVLPCHTTVAIRQgltitacLAFVNSCVNPLIYSLLDRHFRR 277
7tmA_PAR cd15162
protease-activated receptors, member of the class A family of seven-transmembrane G ...
26-323 4.73e-11

protease-activated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes purinergic receptor P2Y8 and protease-activated receptors. P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PAR3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341328 [Multi-domain]  Cd Length: 280  Bit Score: 62.85  E-value: 4.73e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  26 FAMVILMAILGNLLVMVAVCRdRQLRKIKTNYFIVSLAFADLLvSVLVMPFG-AIELVQDIWFYGEMFCLVRTSLDVLLT 104
Cdd:cd15162     7 YTLVFVVGLPANGMALWVLLF-RTKKKAPAVIYMANLAIADLL-LVIWLPFKiAYHIHGNNWIFGEALCRLVTVAFYGNM 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 105 TASIFHLCCISLDRYYAIcCQPLVYRNKMTpLRIALMLGGCWVIPMFISFLPIMQGWNNIGIVDVieKRKFNHNSNSTFC 184
Cdd:cd15162    85 YCSILLLTCISIDRYLAI-VHPMGHRRLRA-RRYALGTCLAIWLLALLVTLPLYLVKQTIFLPAL--DITTCHDVLPEQL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 185 VFMVNKPYAITCSVVAFYIPFLLMVLAYyriyvtakehaqqiqmlqraGATSESRPQTADQHSTHRmrtETKAAKTLCVI 264
Cdd:cd15162   161 LVGDWFYYFLSLAIVGFLIPFILTASCY--------------------VATIRTLAALEDENSEKK---KKRAIKLAATV 217
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1938531436 265 MGCFCFCWAPFFVTNIVD-PFIDYTVPEKVWTAF---LWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15162   218 LAIFIICFAPSNLLLLAHySLISSSGTGHLYFAYllaLCLSTLNSCIDPFIYYFVSKEFRDHV 280
7tmA_SREB2_GPR85 cd15218
super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of ...
23-323 6.53e-11

super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320346 [Multi-domain]  Cd Length: 330  Bit Score: 63.13  E-value: 6.53e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  23 LTFFAMVILMAILGNLLVMVAVCRDRQLRKiKTNYFIVSLAFADLLVSVLVMPFgAIELVQD--IWFYGEMFCLVRTSLD 100
Cdd:cd15218     4 LTSLGFIIGVSVVGNLLISILLVKDKTLHR-APYYFLLDLCCSDILRSAICFPF-VFTSVKNgsTWTYGTLTCKVIAFLG 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 101 VLLTTASIFHLCCISLDRYYAICCQPLvYRNKMTPLRIALMLGGCWVIPMFISFLPIMqgwnNIGIVDVI--------EK 172
Cdd:cd15218    82 VLSCFHTAFMLFCISVTRYLAIAHHRF-YTKRLTFWTCLAVICMVWTLSVAMAFPPVL----DVGTYSFIreedqctfQH 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 173 RKFNHNSNSTFCVFMVnkpyAITCSVVAFYIPFLLMVLAYYRIY-VTAKEHAQQIQMLQRAGATSESRP----------- 240
Cdd:cd15218   157 RSFRANDSLGFMLLLA----LILLATQLVYLKLIFFVHDRRKMKpVQFVAAVSQNWTFHGPGASGQAAAnwlagfgrgpt 232
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 241 --------QTADQHSTHRM------RTETKAAKTLCVIMGCFCFCWAPFFVTNIVDPFI-DYTVPEKVWTAFLWLGYINS 305
Cdd:cd15218   233 pptllgirQNANTTGRRRLlvldefKMEKRISRMFYIMTFLFLTLWGPYLVACYWRVFArGPVVPGGFLTAAVWMSFAQA 312
                         330
                  ....*....|....*...
gi 1938531436 306 GLNPFLYAFLNKSFRRAF 323
Cdd:cd15218   313 GINPFVCIFSNRELRRCF 330
7tmA_GPBAR1 cd15905
G protein-coupled bile acid receptor 1, member of the class A family of seven-transmembrane G ...
34-306 7.88e-11

G protein-coupled bile acid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G-protein coupled bile acid receptor GPBAR1 is also known as BG37, TGR5 (Takeda G-protein-coupled receptor 5), M-BAR (membrane-type receptor for bile acids), and GPR131. GPBAR1 is highly expressed in the gastrointestinal tract, but also found at many other tissues including liver, colon, heart, skeletal muscle, and brown adipose tissue. GPBAR1 functions as a membrane-bound receptor specific for bile acids, which are the end products of cholesterol metabolism that facilitate digestion and absorption of lipids or fat-soluble vitamins. Bile acids act as liver-specific metabolic signaling molecules and stimulate liver regeneration by activating GPBAR1 and nuclear receptors such as the farnesoid X receptor (FXR). Upon bile acids binding, GPBAR1 activation causes release of the G-alpha(s) subunit and activation of adenylate cyclase. The increase in intracellular cAMP level then stimulates the expression of many genes via the PKA-mediated phosphorylation of cAMP-response element binding protein (CREB). Thus, GPAR1-signalling exerts various biological effects in immune cells, liver, and metabolic tissues. For example, GPBAR1 activation leads to enhanced energy expenditure in brown adipose tissue and skeletal muscle; stimulation of glucagon-like peptide-1 (GLP-1) production in enteroendocrine L-cells; and inhibition of pro-inflammatory cytokine production in macrophages and attenuation of atherosclerosis development. GPBAR1 is a member of the class A rhodopsin-like family of GPCRs, which comprises receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands.


Pssm-ID: 320571 [Multi-domain]  Cd Length: 272  Bit Score: 62.08  E-value: 7.88e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  34 ILGNLLVMVAVCRDRQLRKiKTNYFIVSLAFADLLVSVlVMPFgaielVQDIWF---YGEMFCLVRTSLDVLLTTASIFH 110
Cdd:cd15905    13 IFANLFIILGIACNRKLHN-TANYFFLSLLLADLLTGV-ALPF-----IPGMSNesrRGYHSCLFVYVAPNFLFLSFLAN 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 111 LCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMqGWNNigivdviekrkFNHNSN-STFCVFMvn 189
Cdd:cd15905    86 LLMVHYERYLCI-VYPLQYHNFWVHRWVPLALLLTWALPLLFACLPAL-GWNN-----------WTPGSNcSYKQVFP-- 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 190 KPYaITCSVVAFYIPFLL-MVLAYYRIYVTAKEHAQQIQMLQRAgatsesrpQTADQHSTHRMRTETKAAKTLCVIMGCF 268
Cdd:cd15905   151 AAY-IYLEVYGLVLPSILaIAFMSVRVLAVARRQLQDICKLLRA--------VQRDGPSELEQQLNLRYAKCIAGVSLTF 221
                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1938531436 269 CFCWAPFFVTNIVDPFIDYTVPEKVWTAFLWLGYINSG 306
Cdd:cd15905   222 LVCWVPYIAYLLMSVLAIEQRPPLSPGTLLILSCVGSG 259
7tmA_BK-2 cd15381
bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled ...
25-321 1.75e-10

bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320503 [Multi-domain]  Cd Length: 284  Bit Score: 61.32  E-value: 1.75e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  25 FFAMVILMAILGNLLVMVAVCRDRQlRKIKTNYFIVSLAFADLLVsVLVMPFGAIELVQDI-WFYGEMFCLVRTSLDVLL 103
Cdd:cd15381     6 YLWIIFVLGTIENAFVLIVFCLHKS-SCTVAEIYLGNLAAADLLL-VCCLPFWAINISNGFnWPFGEFLCKSVNAVIYMN 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 104 TTASIFHLCCISLDRYYAICCQPLVYRnkMTPLRIALMLggCWVIPMF--ISFLPIMqgwnnigivdVIEKRKFNHNSNS 181
Cdd:cd15381    84 LYSSIYFLMMVSIDRYLALVKTMSSGR--MRRPACAKLN--CLIIWMFglLMSTPMI----------VFRTVMYFPEYNI 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 182 TFCVFMVNKPY-----AITCSVVAFYIPFLLMVLAYYRIYVTAKEHAQQIQMLqragatsesrpqtadqhsthrMRTETK 256
Cdd:cd15381   150 TACVLDYPSEGwhvalNILLNVVGFLIPLSIITFCSTQIIQVLRNNKMQKFKE---------------------IQTERK 208
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1938531436 257 AAKTLCVIMGCFCFCWAPFFVTNIVDP-FIDYTVPEKVWTAFL--------WLGYINSGLNPFLYAFLNKSFRR 321
Cdd:cd15381   209 ATVLVLAVLLMFFICWLPFHIFTFLDTlHKLGLISGCRWEDILdigtqiatFLAYSNSCLNPLLYVIVGKHFRK 282
7tmA_OR6C-like cd15912
olfactory receptor subfamily 6C and related proteins, member of the class A family of ...
20-158 1.90e-10

olfactory receptor subfamily 6C and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6C, 6X, 6J, 6T, 6V, 6M, 9A, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320578  Cd Length: 270  Bit Score: 60.96  E-value: 1.90e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLrKIKTNYFIVSLAFADLLVSVLVMP-FGAIELVQD--IWFYGemfCLVR 96
Cdd:cd15912     1 ILLFLLLLLTYLLTLLGNLLIITITLVDHRL-HTPMYFFLRNFSFLEILFTSVVIPkMLANLLSGKktISFAG---CFAQ 76
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1938531436  97 TSLDVLLTTASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIM 158
Cdd:cd15912    77 SFFYFFLGTTEFFLLAVMSFDRYVAI-CNPLHYPTIMNSRVCLQLVLGSWVGGFLLILPPTI 137
7tmA_C5aR cd15114
complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of ...
20-323 2.19e-10

complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320242 [Multi-domain]  Cd Length: 274  Bit Score: 60.88  E-value: 2.19e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVM-VAVCRDRqlRKIKTNYFIvSLAFADLLvSVLVMPFGAIELVQD-IWFYGEMFCLVRT 97
Cdd:cd15114     1 VVALVLYAVVFLVGVPGNALVAwVTGFEAK--RSVNAVWFL-NLAVADLL-CCLSLPILAVPIAQDgHWPFGAAACKLLP 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  98 SLDVLLTTASIFHLCCISLDRyYAICCQPLVYRNKMTPLRIALMLGGCWV------IPMFIsFLPIMQGWNNIGIVDVIE 171
Cdd:cd15114    77 SLILLNMYASVLLLTAISADR-CLLVLRPVWCQNHRRARLAWIACGAAWLlallltVPSFI-YRRIHQEHFPEKTVCVVD 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 172 krkFNHNSNSTFCVfmvnkpyAITCSVVAFYIPFLLMVLAYYRIYVtakehaqqiqMLQRAGATSESRPQtadqhsthrm 251
Cdd:cd15114   155 ---YGGSTGVEWAV-------AIIRFLLGFLGPLVVIASCHGVLLV----------RTWSRRRQKSRRTL---------- 204
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1938531436 252 rtetkaaKTLCVIMGCFCFCWAPFFVTNIVDPFID-----YTVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15114   205 -------KVVTAVVVGFFLCWTPYHVVGLIIAASApnsrlLANALKADPLTVSLAYINSCLNPIIYVVAGRGFRKSL 274
7tmA_OR1A-like cd15235
olfactory receptor subfamily 1A and related proteins, member of the class A family of ...
21-155 2.28e-10

olfactory receptor subfamily 1A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1A, 1B, 1K, 1L, 1Q and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320363 [Multi-domain]  Cd Length: 278  Bit Score: 60.70  E-value: 2.28e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  21 VLLTFFAMVILMAILGNLLVMVAVCRDRQLRkIKTNYFIVSLAFADLLVSVLVMPFGAIELV---QDIWFYGemfCLVRT 97
Cdd:cd15235     3 LLFLLFLAMYLLTLLGNLLIVLLIRSDPRLH-TPMYFFLSHLSLVDICFTSTTVPKMLANLLsgsKTISYAG---CLAQM 78
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1938531436  98 SLDVLLTTASIFHLCCISLDRYYAICcQPLVYRNKMTPLRIALMLGGCWVIPMFISFL 155
Cdd:cd15235    79 YFFIAFGNTDSFLLAVMAYDRYVAIC-HPLHYATVMSPKRCLLLVAGSWLLSHLHSLL 135
7tmA_tmt_opsin cd15086
teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G ...
20-323 2.91e-10

teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G protein-coupled receptors; Teleost multiple tissue (tmt) opsins are homologs of encephalopsin. Mouse encephalopsin (or panopsin) is highly expressed in the brain and testes, whereas the teleost homologs are localized to multiple tissues. The exact functions of the encephalopsins and tmt-opsins are unknown. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Tmt opsins belong to the class A of the G protein-coupled receptors and show strong homology to the vertebrate visual opsins.


Pssm-ID: 320214 [Multi-domain]  Cd Length: 276  Bit Score: 60.52  E-value: 2.91e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKiKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSL 99
Cdd:cd15086     1 TVVAVFLGFILTFGFLNNLLVLVLFCKYKVLRS-PINLLLLNISLSDLLVCVLGTPFSFAASTQGRWLIGEHGCRWYGFA 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 100 DVLLTTASIFHLCCISLDRYYAICCQPLV----YRnkmtplRIALMLGGCWVIPMFISfLPIMQGWNNIGIVDVIEKRKF 175
Cdd:cd15086    80 NSLFGIVSLISLAVLSYERYCTLLRPTEAdvsdYR------KAWLGVGGSWLYSLLWT-LPPLLGWSSYGPEGPGTTCSV 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 176 NHNSNSTfcvfmVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKehaqqiqmlqRAGATSESRPQTADQHsthrmrtet 255
Cdd:cd15086   153 QWTSRSA-----NSISYIICLFIFCLLLPFLVMVYCYGRLLYAIK----------QVGKINKSTARKREQH--------- 208
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1938531436 256 kaakTLCVIMG---CFCFCWAPFFVTNIVDPF--IDYTVPEKVWTAFLwLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15086   209 ----VLLMVVTmviCYLLCWLPYGVMALLATFgkPGLVTPVASIVPSI-LAKSSTVVNPIIYVFMNKQFYRCF 276
7tmA_V2R cd15388
vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled ...
20-318 3.16e-10

vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The vasopressin type 2 receptor (V2R) is a G(s)-coupled receptor that controls balance of water and sodium ion by regulating their reabsorption in the renal collecting duct. Mutations of V2R is responsible for nephrogenic diabetes insipidus. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320510 [Multi-domain]  Cd Length: 295  Bit Score: 60.56  E-value: 3.16e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKiKTNYFIVSLAFADLLVSVL-VMPfgaiELVQDIW--FYG-EMFCLV 95
Cdd:cd15388     1 QVEIAVLAIIFACALLSNSLVLLVLWRRRKQLA-RMHVFMLHLCIADLVVAFFqVLP----QLVWDITdrFRGpDVLCRL 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  96 RTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGgcWVIPMFISfLPimqgwnnigIVDVIEKRKF 175
Cdd:cd15388    76 VKYLQVVGMFASSYMIVAMTFDRHQAICRPMVTFQKGRARWNGPVCVA--WAISLILS-LP---------QVFIFSKVEV 143
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 176 NHNSNSTFCVFMVN---KPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAQQIQMLQRAGATSESRPQTADQHSTHRMR 252
Cdd:cd15388   144 APGVYECWACFIEPwglKAYVTWITLVVFVLPTLIITVCQVLIFKEIHINIYLKSQIIVAVVKKKQLLSSRASSVAEVSK 223
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1938531436 253 TETKAAKTLCVIMGCFCFCWAPFFVT---NIVDPfiDYTVPEKVWTAFLWLGYINSGLNPFLYAFLNKS 318
Cdd:cd15388   224 AMIKTVKMTLVIVLVYVLCWAPFFLVqlwSVWDP--KAPTEGATFTILMLLASLNSCTNPWIYMAFSSS 290
7tmA_OR1_7-like cd15918
olfactory receptor families 1, 7, and related proteins, member of the class A family of ...
21-155 5.13e-10

olfactory receptor families 1, 7, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 1 and 7, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320584 [Multi-domain]  Cd Length: 270  Bit Score: 59.55  E-value: 5.13e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  21 VLLTFFAMVILMAILGNLLVMVAVCRDRQLRKiKTNYFIVSLAFADL-LVSVLV--MPFGAIELVQDIWFYGemfCLVRT 97
Cdd:cd15918     2 LLFGLFLGMYLVTVLGNLLIILAIGSDSHLHT-PMYFFLANLSLVDIcFTSTTVpkMLVNIQTQSKSISYAG---CLTQM 77
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1938531436  98 SLDVLLTTASIFHLCCISLDRYYAICcQPLVYRNKMTPLRIALMLGGCWVIPMFISFL 155
Cdd:cd15918    78 YFFLLFGDLDNFLLAVMAYDRYVAIC-HPLHYTTIMSPRLCILLVAASWVITNLHSLL 134
7tmA_RNL3R1 cd15926
relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G ...
20-323 6.71e-10

relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R1 is also known as GPCR135, relaxin family peptide receptor 3 (RXFP3), and somatostatin- and angiotensin-like peptide receptor (SALPR). RNL3/relaxin-3, a member of the insulin superfamily, is an endogenous neuropeptide ligand for RNL3R1. RNL3R1 is predominantly expressed in brain regions and implicated in stress, anxiety, and feeding, and metabolism. RNL3R1 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation, and also activates Erk1/2 signaling pathway.


Pssm-ID: 320592 [Multi-domain]  Cd Length: 288  Bit Score: 59.52  E-value: 6.71e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIKTNYFIVSLAFADLLVsVLVMPFGAIELVQDI-WFYGEMFCLVRTS 98
Cdd:cd15926     1 IIISIVYSVVCALGLVGNLLVLYLMKSKQGWKKSSINLFVTSLAVTDFQF-VLTLPFWAVENALDFtWLFGKAMCKIVSY 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  99 LDVLLTTASIFHLCCISLDRYYAICCqplVYRNKMTPLRIAL--MLGGCWVIPMFISFLPIMQGWNNIGIVDVIEKRKF- 175
Cdd:cd15926    80 VTAMNMYASVFFLTAMSVARYHSVAS---ALKSKRRRGCCSAkwLCVLIWVLAILASLPNAIFSTTATVSNEELCLVKFp 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 176 NHNSNSTFCVFMvnkpYAITCSVVAFYIPFLLMVLAYYRIYvtakehaqqiqmlqragatsesRPQTADQHSTHRMRTET 255
Cdd:cd15926   157 DNRGNAQFWLGL----YHAQKVLLGFLIPLGIISLCYLLLV----------------------RFITDKNITGSSTKRRS 210
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1938531436 256 KAAKTLCVIMGCFCFCWAP---------FFVTNIVDPFIDY-TVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15926   211 KVTKSVTIVVLSFFLCWLPnqalttwgiLIKLNVVHFSYEYfTTQVYIFPITVCLAHSNSCLNPILYCLMRREFRKAL 288
7tmA_VA_opsin cd15082
non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane ...
21-323 6.96e-10

non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The vertebrate ancient (VA) opsin photopigments were originally identified in salmon and they appear to have diverged early in the evolution of vertebrate opsins. VA opsins are localized in the inner retina and the brain in teleosts. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extraretinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity, and body color change. The VA opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320210 [Multi-domain]  Cd Length: 291  Bit Score: 59.43  E-value: 6.96e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  21 VLLTFFAMVILMAILGNLLVMVAVCRDRQLRKiKTNYFIVSLAFADLLVSvlvMPFGAIELVQDI---WFYGEMFCLVRT 97
Cdd:cd15082    15 VLAALMFVVTSLSLAENFAVMLVTFRFKQLRQ-PLNYIIVNLSVADFLVS---LTGGTISFLTNArgyFFLGVWACVLEG 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  98 SLDVLLTTASIFHLCCISLDRYYAIcCQPL---VYRNKMTPLRIALMlggcWVIPMFISFLPIMqGWNNIGIVDVIEKRK 174
Cdd:cd15082    91 FAVTFFGIVALWSLAVLAFERFFVI-CRPLgniRLQGKHAALGLLFV----WTFSFIWTIPPVL-GWSSYTVSKIGTTCE 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 175 FNHNSNStfcvfMVNKPYAITCSVVAFYIPFLLMVLAYYRIyvtakehaqqIQMLQRAGATsESRPQTAdqhsthrMRTE 254
Cdd:cd15082   165 PNWYSGN-----MHDHTYIITFFTTCFILPLGVIFVSYGKL----------LQKLRKVSNT-QGRLGNA-------RKPE 221
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1938531436 255 TKAAKTLCVIMGCFCFCWAPFFVTNIV---DPFIDYTVPEKVWTAFlwLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15082   222 RQVTRMVVVMIVAFMVCWTPYAAFSILvtaHPTIHLDPRLAAIPAF--FSKTAAVYNPIIYVFMNKQFRKCL 291
7tmA_GPR15 cd15194
G protein-coupled receptor 15, member of the class A family of seven-transmembrane G ...
20-322 7.56e-10

G protein-coupled receptor 15, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR15, also called as Brother of Bonzo (BOB), is an orphan G-protein coupled receptor that was originally identified as a co-receptor for human immunodeficiency virus. GPR15 is upregulated in patients with rheumatoid arthritis and shares high sequence homology with angiotensin II type AT1 and AT2 receptors; however, its endogenous ligand is unknown. GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation.


Pssm-ID: 320322 [Multi-domain]  Cd Length: 281  Bit Score: 59.48  E-value: 7.56e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIkTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSL 99
Cdd:cd15194     1 GFLPILYCLVFLVGAVGNAILMGALVFKRGVRRL-IDIFISNLAASDFIFLVTLPLWVDKEVVLGPWRSGSFLCKGSSYI 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 100 DVLLTTASIFHLCCISLDRYYAICcQPLVYRNKMTPLRIALMLGGCWVIPMFISfLPimqgwnnigivdVIEKRKFNHNS 179
Cdd:cd15194    80 ISVNMYCSVFLLTCMSLDRYLAIV-LPLVSRKFRTKHNAKVCCTCVWMLSCLLG-LP------------TLLSRELKKYE 145
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 180 NSTFCVFMVNKPYAITCS----VVAFYIPFLLMVLAYYRIYVTAKEHAQQIQMLQRagatsesrpqtadqhsthRMRtet 255
Cdd:cd15194   146 EKEYCNEDAGTPSKVIFSlvslIVAFFLPLLSILTCYCTIIWKLCHHYQKSGKHQK------------------KLR--- 204
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1938531436 256 KAAKTLCVIMGCFCFCWAPF-------FVTNIVD--PFIDYTVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRA 322
Cdd:cd15194   205 KSIKIVFIVVAAFVFSWMPFnlfkalaIASGLQVevTCLPYTLAQLGMEVSAPLAFANSCANPFIYYFFDRYIRRA 280
7tmA_LPAR cd15101
lysophosphatidic acid receptor subfamily, member of the class A family of seven-transmembrane ...
20-323 8.33e-10

lysophosphatidic acid receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 341325 [Multi-domain]  Cd Length: 274  Bit Score: 59.06  E-value: 8.33e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRkIKTNYFIVSLAFADLLVSV----LVMPFGAI--ELVQDIWFYGEmfC 93
Cdd:cd15101     1 VLVMGLGITVCIFIMLANLLVIAAIYKNRRFH-FPIYYLLANLAAADFFAGLayffLMFNTGPNtrRLTVSTWFLRQ--G 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  94 LVRTSLdvlltTASIFHLCCISLDRYYAICCQPLvyRNKMTPLRIALMLGGCWVIPMFISFLPIMqGWNNIGIVDVIEKR 173
Cdd:cd15101    78 LLDTSL-----TASVANLLAIAVERHISVMRMQL--HSRLSNRRVVVLIVLVWTMAIVMGAIPSV-GWNCLCAIDACSNM 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 174 KFNHnSNSTFCVFMVNKpyaitcsvvafYIPFLLMVLAYYRIYVTAKEHAQqiqmlqragatsesRPQTADQHSTHRMRT 253
Cdd:cd15101   150 APLY-SRSYLVFWAISN-----------LVTFLVMVVVYARIFVYVRRRTN--------------RMSPHTSGSIRNRDT 203
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1938531436 254 ETKAAKTLCVIMGCFCFCWAPFFVTNIVDPF----IDYTVPEKVwtaFLWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15101   204 MMSLLKTVVIVLGAFVVCWTPGLVVLLLDGLccrqCNVLAVEKF---FLLLAEFNSAVNPIIYSYRDKEMSGTF 274
7tmA_V1aR cd15385
vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
23-314 8.35e-10

vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; V1a-type receptor is a G(q/11)-coupled receptor that mediates blood vessel constriction. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320507 [Multi-domain]  Cd Length: 301  Bit Score: 59.45  E-value: 8.35e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  23 LTFFAMVILMAILGNLLVMVAVCRDRQlRKIKTNYFIVSLAFADLLVSVL-VMPfgaiELVQDIW--FYGEMF-CLVRTS 98
Cdd:cd15385     4 IAVLAVIFAVAVIGNSSVLLALYKTKK-KASRMHLFIKHLSLADLVVAFFqVLP----QLCWDITyrFYGPDFlCRIVKH 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  99 LDVLLTTASIFHLCCISLDRYYAIcCQPLVYRNKMTPlRIALMLGGCWVipmfISFLPIMQGWNNIGIVDVIEKRKFnHN 178
Cdd:cd15385    79 LQVLGMFASTYMLVMMTADRYIAI-CHPLKTLQQPTK-RSYLMIGSAWA----LSFILSTPQYFIFSLSEIENGSGV-YD 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 179 SNSTFCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRI-YVTAKEHAQQIQMLQRAGATSESRPQTADQHSTHRMRTETKA 257
Cdd:cd15385   152 CWANFIVPWGIKAYITWITISIFVVPVIILLTCYGFIcYNIWRNIKCKTRRGLSDNALKNILLAVCVSSVKTISRAKIRT 231
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1938531436 258 AKTLCVIMGCFCFCWAPFFVTNIVD------PFIDYTVPEKVWTAFlwLGYINSGLNPFLYAF 314
Cdd:cd15385   232 VKMTFVIVLAYIVCWAPFFTIQMWSvwdqnfPWDESENTAVTITAL--LASLNSCCNPWIYMF 292
7tmA_MC3R cd15352
melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G ...
26-323 8.96e-10

melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320474 [Multi-domain]  Cd Length: 272  Bit Score: 59.13  E-value: 8.96e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  26 FAMVILMAILGNLLVMVAVCRDRQLRKiKTNYFIVSLAFADLLVSV-------LVMPFGAIELVQDIWFYGEMFCLVRTS 98
Cdd:cd15352     7 FLTLGIVSLLENILVILAVVKNKNLHS-PMYFFLCSLAVADMLVSVsnsletiMIAVLNSGYLVISDQFIQHMDNVFDSM 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  99 LDVLLTtASIFHLCCISLDRYYAICcQPLVYRNKMTPLRIALMLGGCWVIPMFIsflpimqgwnniGIVdviekrkfnhn 178
Cdd:cd15352    86 ICISLV-ASICNLLAIAVDRYVTIF-YALRYHSIMTVRKALVLIAVIWVVCIVC------------GIV----------- 140
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 179 snstFCVFMVNKPyAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAQQIQMLQRAGATSESRpqtadqhsthrmRTETKAA 258
Cdd:cd15352   141 ----FIVYSESKT-VIVCLITMFFAMLVLMATLYVHMFLFARLHVKRIAALPPAVDGAPQQ------------RSCMKGA 203
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1938531436 259 KTLCVIMGCFCFCWAPFFVTNIV------DPF-IDYTvpeKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15352   204 VTITILLGVFIVCWAPFFLHLILiiscphNPYcLCYT---SHFNTYLVLIMCNSVIDPLIYAFRSLEMRKTF 272
7tmA_CXCR6 cd15173
CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G ...
20-323 1.04e-09

CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR6 binds specifically to the chemokine CXCL16, which is expressed on dendritic cells, monocyte/macrophages, activated T cells, fibroblastic reticular cells, and cancer cells. CXCR6 is phylogenetically more closely related to CC-type chemokine receptors (CCR6 and CCR9) than other CXC receptors. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320301 [Multi-domain]  Cd Length: 270  Bit Score: 58.63  E-value: 1.04e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIkTNYFIVSLAFADLLVsVLVMPFGAIELVQDiWFYGEMFCLVRTSL 99
Cdd:cd15173     1 YFLPCMYSVMFVTGLVGNSLVIVIYIFYEKLRTL-TDIFLVNLAVADLLF-LCTLPFWAYSAAHE-WIFGTVMCKITNGL 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 100 DVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIA-LMLGGCWVIPMFISFLPIMQGwnnigivdviekrkFNHN 178
Cdd:cd15173    78 YTINLYSSMLILTCITVDRFIVIVQATKAHNCHAKKMRWGkVVCTLVWVISLLLSLPQFIYS--------------EVRN 143
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 179 SNSTFCvFMVNKPYAITCSV------VAFYIPFLLMVLAYYRIyvtakehaqqIQMLQRAGATSESrpqtadqhsthrmr 252
Cdd:cd15173   144 LSSKIC-SMVYPPDAIEVVVniiqmtVGFFLPLLAMIICYSVI----------IKTLLHAKGFQKH-------------- 198
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1938531436 253 tetKAAKTLCVIMGCFCFCWAPF-FVTNIVDPFIDYTVPEKVWTAFL---WLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15173   199 ---KSLKIIFVVVAVFILTQLPYnIMKLIRTLHIENTDSTNFKYAILiteAIAYLHACLNPILYAFVGVKFRKNF 270
7tmA_NPY5R cd15398
neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G ...
22-320 1.14e-09

neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320520 [Multi-domain]  Cd Length: 273  Bit Score: 58.63  E-value: 1.14e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  22 LLTFFAMVILMAILGNLLVMVAVCRDRQLRKIkTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSLDV 101
Cdd:cd15398     3 LIGLYTFISLLGFLGNLLILTALTKKWKQKTI-INFLIGNLAFSDILVVLFCSPFTLTCVLLDQWIFGEVMCHIVPFLQC 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 102 LLTTASIFHLCCISLDRYYAIcCQPLvyRNKMTPLRIALMLGGCWVIPMFI-SFLPIMQgwnniGIVDVIEKRKFNHNSN 180
Cdd:cd15398    82 VSVMVSTLMLMSIAIVRYHMI-KHPL--SNHLTANHGYFLLGTVWTLGFTIcSPLPVFH-----KIVDLSETFNLESLKN 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 181 STFCVfmvnKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEhaqqiqmlqragaTSESRPQTADQHSTHRmrtetkaakt 260
Cdd:cd15398   154 KYLCI----ESWPSDSYRIAFTISLLFVQYILPLVCLTVSH-------------TSVCRSVKRSRSVFYR---------- 206
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1938531436 261 LCVIMGCFCFCWAPFFVTNIVDPFIDYTVPEK----VWTAFLWLGYINSGLNPFLYAFLNKSFR 320
Cdd:cd15398   207 LTIVILAFAVSWMPLHLFHLVTDFNANLISNRhfklVYCICHLLGMLSCCLNPILYGFLNNGIK 270
7tmA_OR cd13954
olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled ...
20-158 1.15e-09

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320092 [Multi-domain]  Cd Length: 270  Bit Score: 58.65  E-value: 1.15e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKiKTNYFIVSLAFADLLVSVLVMP-FGAIELVQD--IWFYGemfCLVR 96
Cdd:cd13954     1 ILLFVLFLLIYLLTLLGNLLIILLVRLDSRLHT-PMYFFLSNLSFLDICYTSVTVPkMLANLLSGDktISFSG---CLTQ 76
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1938531436  97 TSLDVLLTTASIFHLCCISLDRYYAICcQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIM 158
Cdd:cd13954    77 LYFFFSLGGTECFLLAVMAYDRYVAIC-HPLHYPTIMNKRVCILLAAGSWLIGFLNSLIHTV 137
7tmA_RNL3R2 cd15925
relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G ...
20-322 1.51e-09

relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R2 is also known as GPR100, GPR142, and relaxin family peptide receptor 4 (RXFP4). Insulin-like peptide 5 (INSL5) is an endogenous ligand for RNL3R2 and plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. RNL3R2 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation.


Pssm-ID: 320591 [Multi-domain]  Cd Length: 283  Bit Score: 58.35  E-value: 1.51e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVM--VAVCRDRQLRKIKTnyFIVSLAFADLLVSvLVMPFGAIELVQDI-WFYGEMFCLVR 96
Cdd:cd15925     1 ILVALAYGLVCAIGLLGNLAVMylLRNCARRAPPPIDV--FVFNLALADFGFA-LTLPFWAVESALDFhWPFGGAMCKMV 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  97 TSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLgGCWVIPMFISFLPIMQGwnNIGIVDVIEKRKFN 176
Cdd:cd15925    78 LTATVLNVYASVFLLTAMSVTRYWVVASAAGPGTHLSTFWAKIITL-ALWAAALLATVPTAIFA--TEGEVCGVELCLLK 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 177 HNSNSTFCVFMVNKpyaitcSVVAFYIPFLLMVLAYYRIYVTAKEHaqqiqmlqragatsesrpqtadQHSTHRMRTETK 256
Cdd:cd15925   155 FPSNYWLGAYHLQR------VVVAFVVPLGVITTSYLLLLSFLQQH----------------------KVNQNNRQRQSV 206
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1938531436 257 AAKTLCVIMGCFCFCWAPFFVTNIVDPFID----------YTVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRA 322
Cdd:cd15925   207 IARSVRLVVASFFLCWFPNHVVTFWGVLVKfravpwnstfYFIHTYVFPVTTCLAHSNSCLNPVLYCLMRREFRQA 282
7tmA_XCR1 cd15182
XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
24-321 1.78e-09

XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; XCR1 is a chemokine receptor specific for XCL1 and XCL2 (previously called lymphotactin alpha/beta), which differ in only two amino acids. XCL1/2 is the only member of the C chemokine subfamily, which is unique as containing only two of the four cysteines that are found in other chemokine families. Human XCL1/2 has been shown to be secreted by activated CD8+ T cells and upon activation of the innate immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 341337 [Multi-domain]  Cd Length: 271  Bit Score: 58.14  E-value: 1.78e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  24 TFFAMVILMAILGNLLVMVAVCRDRQLRKIkTNYFIVSLAFADLLVSVLvMPFGAIELVQDiWFYGEMFCLVRTSLDVLL 103
Cdd:cd15182     5 VFYYLVFLLSLLGNGLVLWILVKYEKLKTL-TNIFILNLAISDLLFTFT-LPFWASYHSSG-WIFGEILCKAVTSIFYIG 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 104 TTASIFHLCCISLDRYYAICcQPLVYRNKMTPLRIALMLGGCWVIPMFISflpimqgwnnigIVDVIEKRKFNHNSNSTF 183
Cdd:cd15182    82 FYSSILFLTLMTIDRYLAVV-HPLSALRSRKLRYASLVSVAVWVISILAS------------LPELILSTVMKSDEDGSL 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 184 CVFMVNKPY--AITCSVVAFYIPFLLMVLAYYRIyvtakehaqqIQMLQRAgatsesrpqtadqhsthRMRTETKAAKTL 261
Cdd:cd15182   149 CEYSSIKWKlgYYYQQNLFFLIPLGIIVYCYVRI----------LQTLMRT-----------------RTMRKHRTVKLI 201
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1938531436 262 CVIMGCFCFCWAPFFVTNIVDPFIDYTVP-----EKVWTAFLW---LGYINSGLNPFLYAFLNKSFRR 321
Cdd:cd15182   202 FVIVLVFFLSWAPYNIVIFLRSLKDLTIPicecsKQLDYAFYIcrnIAFSHCCLNPVFYVFVGVKFRN 269
7tmA_CCR1 cd15183
CC chemokine receptor type 1, member of the class A family of seven-transmembrane G ...
21-321 1.80e-09

CC chemokine receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR1 is widely expressed on both hematopoietic and non-hematopoietic cells and binds to the inflammatory CC chemokines CCL3, CCL5, CCL6, CCL9, CCL15, and CCL23. CCR1 activates the typical chemokine signaling pathway through the G(i/o) type of G proteins, causing inhibition of adenylate cyclase and stimulation of phospholipase C, PKC, calcium flux, and PLA2. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320311 [Multi-domain]  Cd Length: 278  Bit Score: 57.96  E-value: 1.80e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  21 VLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIkTNYFIVSLAFADLLVsVLVMPFGAIELVQDIWFYGEMFCLVRTSLD 100
Cdd:cd15183     2 LLPPLYSLVFIIGVVGNVLVVLVLIQHKRLRNM-TSIYLFNLAISDLVF-LFTLPFWIDYKLKDDWIFGDAMCKFLSGFY 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 101 VLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLgGCWVIPMFISFLPIMQGWNNIGIVDVIEKRKFNHNSN 180
Cdd:cd15183    80 YLGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGIITSI-ITWALAILASMPCLYFFKSQWEFTHHTCSAHFPRKSL 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 181 STFCVFMvnkpyAITCSVVAFYIPFLLMVLAYYRIyvtakehaqqIQMLQRagatsesRPQtadqhsthrmRTETKAAKT 260
Cdd:cd15183   159 IRWKRFQ-----ALKLNLLGLILPLLVMIICYTGI----------INILLR-------RPN----------EKKAKAVRL 206
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 261 LCVIMGCFCFCWAPFFVTNIVDPFIDYT-VPEKVWTAFLWL--------GYINSGLNPFLYAFLNKSFRR 321
Cdd:cd15183   207 IFVITLLFFLLWTPYNLAAFVSAFQDVLfTPSCEQSQQLDLalqvteviAYTHCCVNPVIYVFVGERFRK 276
7tmA_OT_R cd15387
oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
21-314 2.25e-09

oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Oxytocin is a peptide of nine amino acids synthesized in the hypothalamus and is released from the posterior pituitary gland. Oxytocin plays an important role in sexual reproduction of both sexes and is structurally very similar to vasopressin. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320509 [Multi-domain]  Cd Length: 297  Bit Score: 57.90  E-value: 2.25e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  21 VLLTFFAMVILMAILGNLLVMVAVCRDRQlRKIKTNYFIVSLAFADLLVSVL-VMPfgaiELVQDIWF--YGEMF-CLVR 96
Cdd:cd15387     2 VEVTVLALILFLALTGNICVLLAIHTTRH-KHSRMYFFMKHLSIADLVVAVFqVLP----QLIWDITFrfYGPDFlCRLV 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  97 TSLDVLLTTASIFHLCCISLDRYYAIcCQPLVYRNKMTPlRIALMLGgcWVIPMFISflpIMQgwnnIGIVDVIEKRKFN 176
Cdd:cd15387    77 KYLQVVGMFASTYMLLLMSIDRCLAI-CQPLRSLHRRSD-RVYVLFS--WLLSLVFS---IPQ----VHIFSLREVGNGV 145
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 177 HNSNSTFCVFMVNKPYAITCSVVAFYIPFLLMVLAY----YRIYVTAKEHAQQIQMLQRAGATSE----SRPQTADQHST 248
Cdd:cd15387   146 YDCWADFIQPWGPKAYITWITLSVYIIPVLILSVCYglisFKIWQNVKLKTRRETKTPLSSAASGgaalARVSSVKLISK 225
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1938531436 249 HRMRTetkaAKTLCVIMGCFCFCWAPFFVTNIVDPFiDYTVPEKV--WTAFLWLGYINSGLNPFLYAF 314
Cdd:cd15387   226 AKIRT----VKMTFVIVLAYIVCWTPFFFVQMWSVW-DPNAPKEAspFIIAMLLASLNSCCNPWIYMF 288
7tmA_Proton-sensing_R cd15160
proton-sensing G protein-coupled receptors, member of the class A family of ...
58-322 2.63e-09

proton-sensing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Proton/pH-sensing G-protein coupled receptors sense pH of 7.6 to 6.0. They mediate a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. The proton/pH-sensing receptor family includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4).


Pssm-ID: 320288 [Multi-domain]  Cd Length: 280  Bit Score: 57.78  E-value: 2.63e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  58 FIVSLAFADLLvSVLVMPFGAI-ELVQDIWFYGEMFCLVRTSLDVLLTTASIFHLCCISLDRYYAIcCQPLVYRNKMTpL 136
Cdd:cd15160    38 YLLNLSLSDLL-YILTLPLWIDyTANHHNWTFGPLSCKVVGFFFYTNIYASIGFLCCIAVDRYLAV-VHPLRFRGLRT-R 114
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 137 RIALMLGGC-WVIPMFISFLPIMqgwnnigivdviEKRKFNHNSNSTFCV-------FMVNKPYAITCsvVAFYIPFLLM 208
Cdd:cd15160   115 RFALKVSASiWVLELGTHSVFLG------------HDELFRDEPNHTLCYekypmegWQASYNYARFL--VGFLIPLSLI 180
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 209 VLAYYRIYvtakehaqqiQMLQRAGATSESRPQtadqhsthrmrtetKAAKTLCVIMGCFCFCWAPFFVTNIVDPFIDYT 288
Cdd:cd15160   181 LFFYRRVL----------RAVRQSPSLEREEKR--------------KIIGLLLSIVVIFLLCFLPYHVVLLVRSVIELV 236
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1938531436 289 VP------EKVWTA---FLWLGYINSGLNPFLYAFLNKSFRRA 322
Cdd:cd15160   237 QNglcgfeKRVFTAyqiSLCLTSLNCVADPILYIFVTEDVRQD 279
7tmA_Parietopsin cd15085
non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled ...
31-320 2.78e-09

non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Parietopsin is a non-visual green light-sensitive opsin that was initially identified in the parietal eye of lizards. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Parietopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320213 [Multi-domain]  Cd Length: 280  Bit Score: 57.56  E-value: 2.78e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  31 LMAILGNLLVMVAVCRDRQLRKiKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSLDVLLTTASIFH 110
Cdd:cd15085    12 TFSIFNNVLVIAVTLKNPQLRN-PINIFILNLSFSDLMMALCGTTIVTVTNYEGYFYLGDAFCIFQGFAVNYFGIVSLWS 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 111 LCCISLDRYYAICcQPLVYRnKMTPLRIALMLGGCWVIPMFISFLPIMqGWNNIGIVDVIEKRKFNHNSNStfcvfMVNK 190
Cdd:cd15085    91 LTLLAYERYNVVC-KPMGGL-KLSTKRGYQGLLFIWLFCLFWAVAPLF-GWSSYGPEGVQTSCSIGWEERS-----WSNY 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 191 PYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAQQIQmlQRAGATSEsrpqtadqhsthrmRTETKAAKTLCVIMGCFCF 270
Cdd:cd15085   163 SYLILYFLMCFVIPVAIIGFSYGNVLRSLHKLNKKIE--QQGGKNCP--------------EEEERAVIMVLAMVIAFLI 226
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1938531436 271 CWAP---FFVTNIVDPFIdyTVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFR 320
Cdd:cd15085   227 CWLPytvFALIVVVNPEL--SISPLAATMPTYFAKTSPVYNPIIYIFLNKQFR 277
7tmA_LTB4R2 cd15122
leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of ...
25-314 2.87e-09

leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320250 [Multi-domain]  Cd Length: 281  Bit Score: 57.51  E-value: 2.87e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  25 FFAMVILMAILGNLLVMVAV-CRDRQLRKIKTNYFIVSLAFADLLVsVLVMPFGAIELVQDIWFYGEMFCLVRTSLDVLL 103
Cdd:cd15122     6 FLLLAALLGLPGNGFIIWSIlWKMKARGRSVTCILILNLAVADGAV-LLLTPFFITFLTRKTWPFGQAVCKAVYYLCCLS 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 104 TTASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIM--QGWNNIGIVDVIEKRKFNHNSNS 181
Cdd:cd15122    85 MYASIFIIGLMSLDRCLAV-TRPYLAQSLRKKALVRKILLAIWLLALLLALPAFVyrHVWKDEGMNDRICEPCHASRGHA 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 182 TFCVFMVnkpyaitcSVVAFYIPFLLMVLAYyriyvtakehaqqIQMLQRAGATSesrpqtadqhSTHRMRTEtkaaKTL 261
Cdd:cd15122   164 IFHYTFE--------TLVAFVLPFGVILFSY-------------SVILVRLKGAR----------FRRRARVE----KLI 208
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1938531436 262 CVIMGCFCFCWAPFFVTNIVDPFIDYTVPE------KVWTAF----LWLGYINSGLNPFLYAF 314
Cdd:cd15122   209 AAIVVAFALLWVPYHVVNLLQVVANLAPGEvleklgGAAKAAragaTALAFFSSSVNPLLYVF 271
7tmA_P2Y6_P2Y3-like cd15968
P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of ...
26-321 3.89e-09

P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes P2Y receptor 6 (P2Y6), P2Y3, and P2Y3-like proteins. These receptors belong to the G(i) class of a family of purinergic G-protein coupled receptors. In the CNS, P2Y6 plays a role in microglia activation and phagocytosis, and is involved in the secretion of interleukin from monocytes and macrophages in the immune system. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320634 [Multi-domain]  Cd Length: 285  Bit Score: 57.09  E-value: 3.89e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  26 FAMVILMAILGNLLVMVAVCRDRQlRKIKTNYFIVSLAFADLLVSvLVMPFGAIELVQ-DIWFYGEMFCLVRTSLDVLLT 104
Cdd:cd15968     7 YSFVFLLGLPLNSVVLTRCCRHTK-AWTRTAIYMVNLALADLLYA-LSLPLLIYNYAMrDRWLFGDFMCRLVRFLFYFNL 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 105 TASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVIpMFISFLPIMQGWNNIGIVDviEKRKFNHNSNSTFC 184
Cdd:cd15968    85 YGSILFLTCISVHRYLGI-CHPMRPWHKETRRAAWLTCVLVWIL-VFAQTLPILIFARTGIIRN--RTVCYDLAPPALFP 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 185 VFMvnkPYAITCSVVAFYIPFLLMVLAYYRIYVTAkehaqqIQMLQRAGATSESRpqtadqhsthrmrtETKAAKTLCVI 264
Cdd:cd15968   161 HYV---PYGMALTVSGFLLPFSIILWCYCLVVRTL------CRTLGPAEPPAQAR--------------RRKSIRTIVTV 217
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1938531436 265 MGCFCFCWAPFFVTNI------VDPFIDYTVPEKVWTAF-LW--LGYINSGLNPFLYAFLNKSFRR 321
Cdd:cd15968   218 TLLFALCFLPFHITRTiylavrVTPGVPCHVLEAVAACYkITrpLASANSVLNPLLYFLTKKKFGR 283
7tmA_TSH-R cd15964
thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family ...
29-321 4.35e-09

thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. TSH-R plays an important role thyroid physiology, and its activation stimulates the production of thyroxine (T4) and triiodothyronine (T3). Defects in TSH-R are a cause of several types of hyperthyroidism. The receptor is predominantly found on the surface of the thyroid epithelial cells and couples to the G(s)-protein and activates adenylate cyclase, thereby promoting cAMP production. TSH and cAMP stimulate thyroid cell proliferation, differentiation, and function.


Pssm-ID: 320630 [Multi-domain]  Cd Length: 275  Bit Score: 56.84  E-value: 4.35e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  29 VILMAILGNLLVMVaVCRDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMF-------CLVRTSLDV 101
Cdd:cd15964    10 VNLLAILGNVFVLL-ILLTSHYKLTVPRFLMCNLAFADFCMGIYLLLIASVDLHTRSEYYNHAIdwqtgpgCNTAGFFTV 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 102 LLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGcWVIPMFISFLPIMqGWNNIGIVDVIEKRKFNHNSNS 181
Cdd:cd15964    89 FASELSVYTLTVITLERWYAITFAMRLDRKIRLRHASAIMLGG-WVFCFLLALLPLV-GVSSYAKVSICLPMDTETPLAQ 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 182 TFCVFMvnkpyaITCSVVAFYIpfllMVLAYYRIYVTAKEhaqqiqmlqragatsesrPQTadqhstHRMRTETKAAKTL 261
Cdd:cd15964   167 AYIVFV------LMLNIIAFVI----ICACYIKIYITVRN------------------PQY------KSGDKDTKIAKRM 212
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1938531436 262 CVIMGCFCFCWAP---FFVTNIVD-PFIDYTVPEKVWTAFLWLgyiNSGLNPFLYAFLNKSFRR 321
Cdd:cd15964   213 AVLIFTDFICMAPisfYALSAILNkPLITVSNSKILLVLFYPL---NSCANPFLYAIFTKAFRR 273
7tmA_Parapinopsin cd15075
non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled ...
20-321 7.40e-09

non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the non-visual pineal pigment, parapinopsin, which is a member of the class A of the seven transmembrane G protein-coupled receptors. Parapinopsin serves as a UV-sensitive pigment for the wavelength discrimination in the pineal-related organs of lower vertebrates such as reptiles, amphibians, and fish. Although parapinopsin is phylogenetically related to vertebrate visual pigments such as rhodopsin, which releases its retinal chromophore and bleaches, the parapinopsin photoproduct is stable and does not bleach. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells.


Pssm-ID: 320203 [Multi-domain]  Cd Length: 279  Bit Score: 56.32  E-value: 7.40e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKiKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSL 99
Cdd:cd15075     1 TILSIIMAVFSIASVVLNATVIIVTLRHKQLRQ-PLNYALVNLAVADLGTTVFGGLLSVVTNAVGYFNLGRVGCVLEGFA 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 100 DVLLTTASIFHLCCISLDRYYAICcQPLvYRNKMTPLRIALMLGGCWVIPmFISFLPIMQGWNNIGIVDVIEKRKFNHNS 179
Cdd:cd15075    80 VAFFGIAALCTVAVIAVDRLFVVC-KPL-GTLTFQTRHALAGIASSWLWS-LIWNTPPLFGWGSYQLEGVMTSCAPDWYS 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 180 NStfcvfMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAQQiqmlqragatsesrpQTADQHSTHRmrTETKAAK 259
Cdd:cd15075   157 RD-----PVNVSYILCYFSFCFAIPFAIILVSYGYLLWTLRQVAKL---------------GVAEGGSTAK--AEVQVAR 214
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1938531436 260 TLCVIMGCFCFCWAP---FFVTNIVDPfiDYTVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRR 321
Cdd:cd15075   215 MVVVMVMAFLLCWLPyaaFALTVVSKP--DVYINPLIATVPMYLAKSSTVYNPIIYIFMNKQFRD 277
7tmA_GPR182 cd14988
G protein-coupled receptor 182, member of the class A family of seven-transmembrane G ...
20-323 8.60e-09

G protein-coupled receptor 182, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR182 is an orphan G-protein coupled receptor that belongs to the class A of seven-transmembrane GPCR superfamily. When GPR182 gene was first cloned, it was proposed to encode an adrenomedullin receptor. However when the corresponding protein was expressed, it was found not to respond to adrenomedullin (ADM). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320119 [Multi-domain]  Cd Length: 278  Bit Score: 55.94  E-value: 8.60e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRdRQLRKIKTNYFIVSLAFADLLVsVLVMPFGAIELVQD-IWFYGEMFCLVRTS 98
Cdd:cd14988     1 VVLFILYLVIFVVGLVENVLVIWVNWH-RWGSKNLVNLYILNMAIADLGV-VLTLPVWMLEVMLDyTWLWGSFLCKFTHY 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  99 LDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLgGCWVIPMFISFLPIMqgwnNIGIVDVIEKrkfnhn 178
Cdd:cd14988    79 FYFANMYSSIFFLTCLSVDRYLTLTSSSPFWQQHQHRIRRALCA-GIWVLSAIIPLPEVV----HMQLLDGVEP------ 147
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 179 snstFCVFMVNK--------PYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAQqiqmlqragatSESRpqtadqhsthr 250
Cdd:cd14988   148 ----MCLFLAPFetydewalAVSLLTLIIGFLIPFSIIAVFNVLTARYIRTAGR-----------PESR----------- 201
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 251 mrtetKAAKTLCVIMGCFCFCWAPFFVTNIVDPFIDYTVPEKVWTA-FLWLGY--------INSGLNPFLYAFLNKSFRR 321
Cdd:cd14988   202 -----RHCLLIYAYILVFVVCWLPYHVTLLLLTLHGSHISLHCNLVhFLYFFYdvidcfslLHCVANPILYNFLSKSFRG 276

                  ..
gi 1938531436 322 AF 323
Cdd:cd14988   277 KL 278
7tmA_OR13-like cd15232
olfactory receptor family 13 and related proteins, member of the class A family of ...
20-153 1.03e-08

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13A1 and 13G1) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320360 [Multi-domain]  Cd Length: 270  Bit Score: 55.73  E-value: 1.03e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRkIKTNYFIVSLAFADLLVSVLVMPFGAIELV---QDIWFYGemfCLVR 96
Cdd:cd15232     1 VLLFWLFLFLYAAALTGNSLIILAISTSPKLH-TPMYFFLVNLSLVDIICTSTVVPKLLQNLLterKTISFGG---CMAQ 76
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1938531436  97 TSLDVLLTTASIFHLCCISLDRYYAICCqPLVYRNKMTPLRIALMLGGCWVIPMFIS 153
Cdd:cd15232    77 LYFFTWSLGSELLLLTAMAYDRYVAICH-PLHYSTIMRKEVCVGLATGVWAIGMLNS 132
7tmA_CCR9 cd15174
CC chemokine receptor type 9, member of the class A family of seven-transmembrane G ...
25-215 1.61e-08

CC chemokine receptor type 9, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR9 is a homeostatic receptor specific for CCL25 (formerly known as thymus expressed chemokine) and is highly expressed on both immature and mature thymocytes as well as on intestinal homing T Lymphocytes and mucosal Lymphocytes. In cutaneous melanoma, activation of CCR9-CCL25 has been shown to stimulate metastasis to the small intestine. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 320302 [Multi-domain]  Cd Length: 280  Bit Score: 55.14  E-value: 1.61e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  25 FFAMVILMAILGNLLVMVAVCRDRQlRKIKTNYFIVSLAFADLLVsVLVMPFGAIELVQDiWFYGEMFCLVRTSLDVLLT 104
Cdd:cd15174     6 LYWLIFLVGAVGNSLVVLIYTYYRR-RKTMTDVYLLNLAIADLLF-LCTLPFWATAASSG-WVFGTFLCKVVNSMYKINF 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 105 TASIFHLCCISLDRYYAI--CCQPLVYRNKMTpLRIALMLGGCWVIPMFISFLPIMQGwnnigivdviekrKFNHNSNST 182
Cdd:cd15174    83 YSCMLLLTCISVDRYIAIvqATKAHNSKNKRL-LYSKLVCFFVWLLSTILSLPEILFS-------------QSKEEESVT 148
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1938531436 183 FCVF-------MVNKPYAITCSV-VAFYIPFLLMVLAYYRI 215
Cdd:cd15174   149 TCTMvypsnesNRFKVAVLALKVtVGFFLPFVVMVICYTLI 189
7tmA_OR12D-like cd15915
olfactory receptor subfamily 12D and related proteins, member of the class A family of ...
21-155 1.76e-08

olfactory receptor subfamily 12D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 12D and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320581 [Multi-domain]  Cd Length: 271  Bit Score: 55.00  E-value: 1.76e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  21 VLLTFFAMVILMAILGNLLVMVAVCRDRQLRKiKTNYFIVSLAFADLLVSVLVMP---FGAIELVQDIWFYGemfCLVRT 97
Cdd:cd15915     2 FLFVLFLLLYLASLLGNGAILAVVIAEPRLHS-PMYFFLGNLSCLDIFYSSVTVPkmlAGLLSEHKTISFQG---CISQL 77
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1938531436  98 SLDVLLTTASIFHLCCISLDRYYAICcQPLVYRNKMTPLRIALMLGGCWVIPMFISFL 155
Cdd:cd15915    78 HFFHFLGSSEAMLLAVMAYDRYVAIC-NPLRYTVIMNPQVCLLLAVACWVTGFFHALM 134
7tmA_OR14-like cd15227
olfactory receptor family 14 and related proteins, member of the class A family of ...
20-155 1.87e-08

olfactory receptor family 14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 14 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320355  Cd Length: 270  Bit Score: 54.77  E-value: 1.87e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRkikT--NYFIVSLAFADL-LVSVLVMPFGAIELVQD--IWFYGemfCL 94
Cdd:cd15227     1 ILHFVLFLLIYLAALTGNLLIITVVTLDHHLH---TpmYFFLKNLSFLDLcYISVTVPKSIANSLTNTrsISFLG---CV 74
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1938531436  95 VRTSLDVLLTTASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVIPMFISFL 155
Cdd:cd15227    75 AQVFLFIFFAASELALLTVMAYDRYVAI-CHPLHYEVIMNRGACVQMAAASWLSGLLYGAL 134
7tmA_Pinopsin cd15084
non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled ...
28-329 4.47e-08

non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Pinopsins are found in the pineal organ of birds, reptiles and amphibians, but are absent from teleosts and mammals. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Pinopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320212 [Multi-domain]  Cd Length: 295  Bit Score: 54.10  E-value: 4.47e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  28 MVILMAILGNLLVMVAVCRDRQLRKiKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSLDVLLTTAS 107
Cdd:cd15084    19 MVVALASFVNGLVIVVSIKYKKLRS-PLNYILVNLAVADLLVTLFGSSVSFSNNIVGFFVFGKTMCEFEGFMVSLTGIVG 97
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 108 IFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVipmFISFLPIMQGWNNI---GIVDVIEKRKFNHNSNstfc 184
Cdd:cd15084    98 LWSLAILAFERYLVICKPMGDFRFQQRHAVSGCAFTWGWS---LLWTSPPLFGWSSYvpeGLRTSCGPNWYTGGTN---- 170
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 185 vfmvNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAQQiqmlQRAGATSEsrpqtadqhsthrmRTETKAAKTLCVI 264
Cdd:cd15084   171 ----NNSYILALFVTCFALPLSTIIFSYSNLLLTLRAVAAQ----QKESETTQ--------------RAEKEVTRMVIAM 228
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1938531436 265 MGCFCFCWAPFFVTNIVDPFIDYTVPEKVWTAF-LWLGYINSGLNPFLYAFLNKSFRRAFLIILCC 329
Cdd:cd15084   229 VMAFLICWLPYATFAMVVATNKDVVIQPTLASLpSYFSKTATVYNPIIYVFMNKQFRSCLLELLCC 294
7tmA_P2Y1-like cd15967
P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically ...
22-319 4.74e-08

P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically related to a family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320633 [Multi-domain]  Cd Length: 281  Bit Score: 53.93  E-value: 4.74e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  22 LLTFFAMVILMAILGNLLVMVAVCRDRQlrKIKT-NYFIVSLAFADLLVsVLVMPF-GAIELVQDIWFYGEMFCLVRTSL 99
Cdd:cd15967     3 LPPVYILVFVVGLVGNVWGLKSLLANWK--KLGNiNVFVLNLGLADLLY-LLTLPFlVVYYLKGRKWIFGQVFCKITRFC 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 100 DVLLTTASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVIpMFISFLPimqgwnnigivDVIEKRKfnhNS 179
Cdd:cd15967    80 FNLNLYGSIGFLTCISVYRYLAI-VHPMRVMGRITTTHSVVISALVWLL-VVIQSLP-----------DLFFSKT---NS 143
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 180 NSTFCVFMVNK-------PYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAQQIQMLQRagatsesrpqtadqhsthrmr 252
Cdd:cd15967   144 NGTKCFDTTFNdylesylTYSLGWTVTGFVIPLLIILGCYGHVVVVLCRNNNVDKGLKQ--------------------- 202
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1938531436 253 tetKAAKTLCVIMGCFCFCWAPFFVTNIVDPFIDYTVPEKV---WTAFLWLGY--------INSGLNPFLYAFLNKSF 319
Cdd:cd15967   203 ---RCLKLVIILIVLFSVCYIPYHVFRNLNLLSRILQKQGSctqWFRGIYIAHqvsrglvcLNSALNPLVYLMGSEDI 277
7tmA_GPR4 cd15366
proton-sensing G protein-coupled receptor 4, member of the class A family of ...
24-320 6.14e-08

proton-sensing G protein-coupled receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein-coupled receptor 4 (GPR4) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 receptor (TDAG8, GPR65), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. GPR4 overexpression in melanoma cells was shown to reduce cell migration, membrane ruffling, and cell spreading under acidic pH conditions. Activation of GPR4 via extracellular acidosis is coupled to the G(s), G(q), and G(12/13) pathways.


Pssm-ID: 320488 [Multi-domain]  Cd Length: 280  Bit Score: 53.65  E-value: 6.14e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  24 TFFAMVILMAILGNLLVMVAVCRD-RQLRKIktNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSLDVL 102
Cdd:cd15366     5 TLYIIVIVLGLPTNCLALWAAYLQvRQRNEL--GVYLLNLSVSDLLYIATLPLWIDYFLHRDNWIHGPESCKLFGFIFYT 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 103 LTTASIFHLCCISLDRYYAIcCQPLVYRnKMTPLRIALMLGG-CWVIPMFISFLPIMQgwnnigivDVIEKRKFNHnsns 181
Cdd:cd15366    83 NIYISIAFLCCISVDRYLAV-AHPLRFA-KVRRVKTAVAVSAvVWAIEIGANSAPLFH--------DELFRDRYNH---- 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 182 TFCVfmvnKPYAITCSV---------VAFYIPFLLMVLAYyriyvtakehaQQIQMLQRAGATSESRpqtadqhstHRMR 252
Cdd:cd15366   149 TFCF----EKYPMEDWVawmnlyrvfVGFLFPWVLMLFSY-----------RGILRAVRGNVSTEQQ---------EKAK 204
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1938531436 253 TETKAAKTLCVIMgcfcFCWAPFFVTNIVDPFI------DYTVPEKVWTAF---LWLGYINSGLNPFLYAFLNKSFR 320
Cdd:cd15366   205 IKRLALSLIAIVL----LCFAPYHVLLLSRSVVylgkpcDCGFEERVFTAYhvsLALTSLNCVADPILYCLVNEGAR 277
7tmA_CMKLR1 cd15116
chemokine-like receptor 1, member of the class A family of seven-transmembrane G ...
20-323 6.21e-08

chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokine receptor-like 1 (also known as Chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. CMKLR1 is prominently expressed in dendritic cells and macrophages.


Pssm-ID: 320244 [Multi-domain]  Cd Length: 284  Bit Score: 53.61  E-value: 6.21e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVmVAVCRDRQLRKIKTNYFIvSLAFADLLVSVlVMPFGAIELVQDI-WFYGEMFCLVRTS 98
Cdd:cd15116     1 ILSMVIYSVVFVLGVLGNGLV-IFITGFKMKKTVNTVWFL-NLAVADFLFTF-FLPFSIAYTAMDFhWPFGRFMCKLNSF 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  99 LDVLLTTASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIM-------QGWNNIGIVDVIE 171
Cdd:cd15116    78 LLFLNMFTSVFLLTVISIDRCISV-VFPVWSQNHRSVRLASLVSLAVWVVAFFLSSPSFIfrdtapsQNNNKIICFNNFS 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 172 KRKFNHNSNSTFCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTakehaqqiqmLQRagatsesrpqtadqhstHRM 251
Cdd:cd15116   157 LSGDNSSPEVNQLRNMRHQVMTITRFLLGFLIPFTIIICCYAAIVLK----------LKR-----------------NRL 209
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1938531436 252 RTETKAAKTLCVIMGCFCFCWAPFFVTNIV----DPFIDYT--VPEKVWTAflwLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15116   210 AKSSKPFKIIAAVIVTFFLCWAPYHILNLLemeaTRSPASVfkIGLPITSS---LAFINSCLNPILYVFMGQDFKKFK 284
7tmA_OR13H-like cd15431
olfactory receptor subfamily 13H and related proteins, member of the class A family of ...
20-218 6.46e-08

olfactory receptor subfamily 13H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 13H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320548 [Multi-domain]  Cd Length: 269  Bit Score: 53.38  E-value: 6.46e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKiKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSL 99
Cdd:cd15431     1 IILFVLLLIVYLVTLLGNGLIILLIRVDSQLHT-PMYFFLSNLSFLDICYTTSSVPQMLVNCLSDRPTISYSRCLAQMYI 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 100 DVLLTTASIFHLCCISLDRYYAICcQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMQ------GWNNIgivdviekr 173
Cdd:cd15431    80 SLFLGITECLLLAVMAYDRFVAIC-NPLRYTLIMSWRVCIQLAAGSWVSAFLLTVIPVLTmplhfcGPNVI--------- 149
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1938531436 174 kfNH------------NSNSTFCVFMVnkpyaITCSVVAFYIPFLLMVLAYYRIYVT 218
Cdd:cd15431   150 --NHffcevqallklaCSDTSLNEILM-----FATSIFTLLLPFSFILVSYIRIGVA 199
7tmA_P2Y10 cd15153
P2Y purinoceptor 10, member of the class A family of seven-transmembrane G protein-coupled ...
24-320 8.94e-08

P2Y purinoceptor 10, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y10 receptor is a G-protein coupled receptor that is activated by both sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA). Phylogenetic analysis of the class A GPCRs shows that P2Y10 is grouped into the cluster comprising nucleotide and lipid receptors. Although the mouse P2Y10 was found to be expressed in brain, lung, reproductive organs, and skeletal muscle, the physiological function of this receptor is not yet known. S1P and LPA are bioactive lipid molecules that induce a variety of cellular responses through G proteins: adhesion, invasion, cell migration and proliferation, among many others.


Pssm-ID: 320281 [Multi-domain]  Cd Length: 283  Bit Score: 52.87  E-value: 8.94e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  24 TFFAMVILMAILGNLLVMVAVCRDRQlRKIKTNYFIVSLAFADLlVSVLVMPFGAIELVQDIWFYGEMFCLVRTSLDVLL 103
Cdd:cd15153     5 TTYIIIFIPGLLANSAALWVLCRFIS-KKNKAIIFMINLAVADL-AHVLSLPLRIHYYIQHTWPFGRFLCLLCFYLKYLN 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 104 TTASIFHLCCISLDRYYAICcQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMQGWNNigivdviekrkfNHNSNSTF 183
Cdd:cd15153    83 MYASICFLTCISIQRCFFLL-HPFKARDWKRRYDVGISAAVWIVVGLACLPFPLLRSKSL------------SNNNRSCF 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 184 CVFMVNKP---YAITCSVVA----FYIPFLLMVLAYYRIYVTAKEHAQQIQmlqragATSESRpqtadqhsthrmrtetK 256
Cdd:cd15153   150 ADLGMKKLnfgAAIAMMTVAelfgFVIPLFIIAWCTWKTENSLRQRNKQQQ------STSEKQ----------------K 207
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1938531436 257 AAKTLCVIMGCFCFCWAP-----FFVTNIVDPFIDYTVPEKVWTAF----LWLGYINSGLNPFLYAFLNKSFR 320
Cdd:cd15153   208 ALRMVRMCAAVFFICFAPyhinfLFYLMVSESIITNCEVSQVILQFhpisLCLASLNCCLDPILYYFMTSEFQ 280
7tmA_OR4Q3-like cd15935
olfactory receptor 4Q3 and related proteins, member of the class A family of ...
22-146 1.12e-07

olfactory receptor 4Q3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q3 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320601 [Multi-domain]  Cd Length: 268  Bit Score: 52.46  E-value: 1.12e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  22 LLTFFAMVILMAILGNLLVMVAVCRDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSLDV 101
Cdd:cd15935     3 LFVLVLACYAAILLGNLLIVVTVHADPHLLQSPMYFFLANLSLIDMTLGSVAVPKVLADLLTCGRTISFGGCMAQLFFLH 82
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1938531436 102 LLTTASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCW 146
Cdd:cd15935    83 FLGGSEMLLLTLMAYDRYVAI-CHPLRYLAVMNRQLCIKLLAACW 126
7tmA_OR5-like cd15230
olfactory receptor family 5 and related proteins, member of the class A family of ...
20-155 1.47e-07

olfactory receptor family 5 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 5, some subfamilies from families 8 and 9, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320358  Cd Length: 270  Bit Score: 52.12  E-value: 1.47e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIKtnYFIVS-LAFADLLVSVLVMPFGAIELVQD---IWFYGemfCLV 95
Cdd:cd15230     1 VPLFVLFLLIYLITLVGNLGMIVLIRIDSRLHTPM--YFFLSnLSFVDICYSSVITPKMLVNFLSEkktISFAG---CAA 75
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  96 RTSLDVLLTTASIFHLCCISLDRYYAICcQPLVYRNKMTPLRIALMLGGCWVIPMFISFL 155
Cdd:cd15230    76 QFFFFAVFGTTECFLLAAMAYDRYVAIC-NPLLYTVIMSKRVCIQLVAGSYLCGFVNSIV 134
7tmA_OR11G-like cd15913
olfactory receptor OR11G and related proteins, member of the class A family of ...
20-157 1.58e-07

olfactory receptor OR11G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11G, 11H, and related proteins in other mammals, and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320579  Cd Length: 270  Bit Score: 52.32  E-value: 1.58e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRkikTNYFIVSLAFADL---LVSVLV--MPFGAIELVQDIWFYGemfCL 94
Cdd:cd15913     1 ILLFSFFSVIYILTLLGNGAIICAVWWDRRLH---TPMYILLGNFSFLeicYVTSTVpnMLVNFLSETKTISFSG---CF 74
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1938531436  95 VRTSLDVLLTTASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPI 157
Cdd:cd15913    75 LQFYFFFSLGTTECFFLSVMAFDRYLAI-CRPLHYPTIMTGQLCGKLVAFCWVCGFLWFLIPV 136
7tmA_LPAR4 cd15155
lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G ...
26-323 1.63e-07

lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 4 (LPAR4) is a G protein-coupled receptor that binds and is activated by the bioactive lipid lysophosphatidic acid (LPA), which is released by activated platelets and constitutively found in serum. Phylogenetic analysis of the class A GPCRs shows that LAPR4 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(12/13) proteins, leading to neurite retraction and stress fiber formation, whereas coupling to G(q) protein leads to increases in calcium levels.


Pssm-ID: 320283 [Multi-domain]  Cd Length: 283  Bit Score: 52.23  E-value: 1.63e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  26 FAMVILMAILGNLLVMVAVCRDRQLRKiKTNYFIVSLAFADLLVsVLVMPFGAIELVQDIWFYGEMFCLVRTSLDVLLTT 105
Cdd:cd15155     7 YSVVFILGLITNCASLFVFCFRMKMRN-ETAIFMTNLAVSDLLF-VFTLPFKIFYNFNRHWPFGDSLCKISGTAFLTNIY 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 106 ASIFHLCCISLDRYYAICcQPLVYRNKMTPLRIALMLGGCWVIpmfisflpIMQGWNNIGIVDVIekrkfNHNSNSTFCV 185
Cdd:cd15155    85 GSMLFLTCISVDRFLAIV-YPFRSRTIRTRRNSAIVCAGVWIL--------VLSGGISASLFSTT-----NVSNTSTTCF 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 186 FMVNK--------PYAITCSVVAFYIPFLLMVLAYYRIYVTAKehaqqiqmlqragatsesRPQTADQHSTHRmrteTKA 257
Cdd:cd15155   151 EGFSKsiwktylsKITIFIEVVGFIIPLLLNLTCSSLVLRTLR------------------KPATLSQIGTNK----EKV 208
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1938531436 258 AKTLCVIMGCFCFCWAPF----FVTNIV-DPFIDYTVPEK----VWTAFLWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15155   209 LKMILVHVAIFVVCFVPYnsilFLYALVrSQAIANCGVERfartMYPITLCLATLNCCFDPFVYYFTSESFQKSF 283
7tmA_BK-1 cd15380
bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled ...
21-320 1.84e-07

bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320502 [Multi-domain]  Cd Length: 286  Bit Score: 52.11  E-value: 1.84e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  21 VLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIKTNYfIVSLAFADLlVSVLVMPFGAIELVQDI-WFYGEMFCLVRTSL 99
Cdd:cd15380     2 VLPTFIIAICFFGLLGNLFVLFVFLLPRRRLTIAEIY-LANLAASDL-VFVLGLPFWAENIRNQFnWPFGNFLCRVISGV 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 100 DVLLTTASIFHLCCISLDRYYAICcQPLVYRN-------KMTPLRIaLMLGGCWVIPMFIsflpimqgwnnigivdvIEK 172
Cdd:cd15380    80 IKANLFISIFLVVAISQDRYRTLV-HTMTSRRqrsrrqaQVICLLI-WVFGGLLSIPTFL-----------------FRS 140
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 173 RKFNHNSNSTFCVFMVNKPY-----AITCSVVAFYIPFLLMVLAYYRIYVTAKEHaqqiqmlqragaTSESRPQTADqhs 247
Cdd:cd15380   141 VKHVPDLNISACILLFPHEAwhfarRVELNIVGFLLPLAAIVFFNFHIIASLRER------------TEESRKRCGG--- 205
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 248 thrmRTETKAAKTLCVIMGCFCFCWAPFFVTnivdPFIDYTVPEKV-----WTAFLWLG--------YINSGLNPFLYAF 314
Cdd:cd15380   206 ----LKDTKATRLILTLVLMFLVCWTPYHFF----AFLDFLFQVEViqgcfWEEFIDLGlqlanffaFANSCLNPVIYVF 277

                  ....*.
gi 1938531436 315 LNKSFR 320
Cdd:cd15380   278 AGKLFR 283
7tmA_OR8H-like cd15411
olfactory receptor subfamily 8H and related proteins, member of the class A family of ...
20-155 2.24e-07

olfactory receptor subfamily 8H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8H, 8I, 5F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320533 [Multi-domain]  Cd Length: 279  Bit Score: 51.93  E-value: 2.24e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKiKTNYFIVSLAFADLLVSVLVMPFGAIELVQD---IWFYGemfCLVR 96
Cdd:cd15411     1 VPLFVLFLVIYVITVMGNLGMILLIRADSQLHT-PMYFFLSNLSFVDFCYSSTITPKALENFLSGrkaISFAG---CFVQ 76
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1938531436  97 TSLDVLLTTASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVIPMFISFL 155
Cdd:cd15411    77 MYFFIALATTECFLLGLMAYDRYVAI-CNPLLYTVVMSRRVCLKLAAGSYAAGFLNSLI 134
7tmA_LTB4R1 cd15121
leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of ...
23-321 2.61e-07

leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320249 [Multi-domain]  Cd Length: 278  Bit Score: 51.74  E-value: 2.61e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  23 LTFFAMVILMAILGNLLVMVAVCRDRQLRKIkTNYFIVSLAFADLLVsVLVMPFGAIELVQDIWFYGEMFCLVRTSLDVL 102
Cdd:cd15121     4 IAILSLAFILGFPGNLFVVWSVLCRMKKRSV-TCILVLNLALADAAV-LLTAPFFLHFLSGGGWEFGSVVCKLCHYVCGV 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 103 LTTASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVIPMFISfLPimqgwnnigivdVIEKRKFNH-NSNS 181
Cdd:cd15121    82 SMYASIFLITLMSMDRCLAV-AKPFLSQKMRTKRSVRALLLAIWIVAFLLS-LP------------MPFYRTVLKkNINM 147
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 182 TFCVFMVNKP-----YAITCSVVAFYIPFLLMVLAYYRIYVtakehaqqiqmlqragatsesRPQTAdqhsthRMRTETK 256
Cdd:cd15121   148 KLCIPYHPSVgheafQYLFETITGFLLPFTAIVTCYSTIGR---------------------RLRSA------RFRRKRR 200
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1938531436 257 AAKTLCVIMGCFCFCWAPFFVTNIVD-------PFIDYTVPEKVWTA---FLWLGYINSGLNPFLYAFLNKSFRR 321
Cdd:cd15121   201 TNRLVVLIIATFALFWLPYHVVNLIQvagalqnQAGNASVLKAAKLArpnVTALAFLSSSVNPVLYAFAGGSLIR 275
7tmA_GPR1 cd15119
G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane ...
20-320 2.63e-07

G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 1 (GPR1) belongs to the class A of the seven transmembrane domain receptors. This is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1. GPR1 is most closely related to another chemerin receptor CMKLR1. In an in-vitro study, GPR1 has been shown to act as a co-receptor to allow replication of HIV viruses.


Pssm-ID: 320247 [Multi-domain]  Cd Length: 278  Bit Score: 51.67  E-value: 2.63e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVcrDRQLRKIKTNYFIVSLAFADLlVSVLVMPFGAIELVQDI-WFYGEMFCLVRTS 98
Cdd:cd15119     1 IVSIVIYIVAFVLGVPGNAIVIWVT--GFKWKKTVNTLWFLNLAIADF-VFVLFLPLHITYVALDFhWPFGVWLCKINSF 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  99 LDVLLTTASIFHLCCISLDRYyaICCQPLVYRNKMTPLRIALMLGGC-WVIPMFISfLPIMQgwnnigIVDVIEkrkFNH 177
Cdd:cd15119    78 VAVLNMFASVLFLTVISLDRY--ISLAHPVWSHRYRTLKSALILCGIvWLSAAAIS-GPALY------FRDTME---LSI 145
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 178 NSNSTFCVFMVNKPYAITCS---------VVAFYIPFLLMVLAYYRIYVTAKehaqqiqmlqragatsesrpqtadqhsT 248
Cdd:cd15119   146 NVTICFNNFHKHDGDLIVMRhtilvwvrfFFGFLFPLLTMVVCYSLLAIKVK---------------------------R 198
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1938531436 249 HRMRTETKAAKTLCVIMGCFCFCWAPFFVTNIVDPFIDYTVPEKVWTAF-----LWLGYINSGLNPFLYAFLNKSFR 320
Cdd:cd15119   199 RTLLISSKFFWTISAVIVAFFVCWTPYHIFSILELSIHHSSYLHNVLRAgiplaTSLAFINSCLNPILYVLIGKKFK 275
7tmA_P2Y6 cd15379
P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled ...
20-321 4.23e-07

P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes mammalian P2Y6, avian P2Y3, and similar proteins. P2Y3 is the avian homolog of mammalian P2Y6. They belong to the G(i) class of a family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320501 [Multi-domain]  Cd Length: 288  Bit Score: 51.03  E-value: 4.23e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKiKTNYFIVSLAFADLLVsVLVMPFGAIELVQ-DIWFYGEMFC-LVRT 97
Cdd:cd15379     1 VLLPLVYSVVFLLGLPLNAVVIGQIWATRQALS-RTTIYMLNLATADLLY-VCSLPLLIYNYTQkDYWPFGDFTCrLVRF 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  98 SLDVLLTtASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIA-LMLGGCWVI------PMFIsflpimqgWNNIGIvdvi 170
Cdd:cd15379    79 QFYTNLH-GSILFLTCISVQRYLGI-CHPLASWHKKKGKKLTwLVCGAVWLVviaqclPTFV--------FASTGT---- 144
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 171 ekrkfnhNSNSTFCVFMVNK-------PYAITCSVVAFYIPFLLMVLAYYRIYVTAkehAQQIQMLQRAGATSESRpqta 243
Cdd:cd15379   145 -------QRNRTVCYDLSPParstayfPYGITLTRTGFLLPFAARLACYCSMATIL---CRVVIAVAVVAAPGEKR---- 210
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 244 dqhsthrmrteTKAAKTLCVIMGCFCFCWAPFFVTNIVDPFIDYT--VPEKVWTAFlWLGY--------INSGLNPFLYA 313
Cdd:cd15379   211 -----------GKAARMIIVVAAVFLISFLPFHYTKTRYLQVRSWdgGPCTTRQAF-AEAYkrtrpfasMNSVLDPILFY 278

                  ....*...
gi 1938531436 314 FLNKSFRR 321
Cdd:cd15379   279 FTQSKFRP 286
7tmA_LWS_opsin cd15081
long wave-sensitive opsins, member of the class A family of seven-transmembrane G ...
29-320 5.06e-07

long wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Long Wave-Sensitive opsin is also called red-sensitive opsin or red cone photoreceptor pigment, which mediates visual transduction in response to light at long wavelengths. Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320209 [Multi-domain]  Cd Length: 292  Bit Score: 50.68  E-value: 5.06e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  29 VILMAILGNLLVMVAVCRDRQLRKiKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSLDVLLTTASI 108
Cdd:cd15081    22 VVFASVFTNGLVLVATLKFKKLRH-PLNWILVNLAIADLGETVIASTISVVNQIFGYFILGHPMCVLEGFTVSVCGITGL 100
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 109 FHLCCISLDRYYAICcQP---LVYRNKMTPLRIALmlggCWVIPMFISFLPIMqGWNNI---GIVDVIEKRKFNHNSNST 182
Cdd:cd15081   101 WSLTIISWERWVVVC-KPfgnIKFDGKLAIVGIIF----SWVWSAVWCAPPIF-GWSRYwphGLKTSCGPDVFSGSSDPG 174
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 183 FCVFMVnkPYAITCSVvafyIPFLLMVLAYYRIYVTAKEHAQQiqmlqragatsesrpqtaDQHSTHRMRTETKAAKTLC 262
Cdd:cd15081   175 VQSYMI--VLMITCCI----IPLAIIILCYLQVWLAIRAVAQQ------------------QKESESTQKAEKEVSRMVV 230
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1938531436 263 VIMGCFCFCWAPF-FVTNIVDPFIDYTVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFR 320
Cdd:cd15081   231 VMIFAYCFCWGPYtFFACFAAANPGYAFHPLAAALPAYFAKSATIYNPIIYVFMNRQFR 289
7tmA_OR8S1-like cd15229
olfactory receptor subfamily 8S1 and related proteins, member of the class A family of ...
20-218 6.67e-07

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 8S1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320357 [Multi-domain]  Cd Length: 277  Bit Score: 50.29  E-value: 6.67e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKiKTNYFIVSLAFADLLVSVLVMPfgaiELVQD-------IWFYGemf 92
Cdd:cd15229     1 IFLFLVFLVIYLLTLLGNLLIMLVIRADSHLHT-PMYFFLSHLSFLDICYSSVTVP----KMLENllserktISVEG--- 72
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  93 CLVRTSLDVLLTTASIFHLCCISLDRYYAICcQPLVYRNKMTPLRIALMLGGCWVIPMFISF---LPIMQgwnnigiVDV 169
Cdd:cd15229    73 CIAQIFFFFFFAGTEAFLLSAMAYDRYAAIC-HPLHYVQIMSKQVCVQLVGGAWALGFLYALintLLLLN-------LHF 144
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1938531436 170 IEKRKFNHNS-----------NSTFCVFMVnkpyaITCSVVAF-YIPFLLMVLAYYRIYVT 218
Cdd:cd15229   145 CGPNEINHFScelpsllplscSDTFANKMV-----LLTSSVIFgLGSFLLTLVSYIHIIST 200
7tmA_HCAR-like cd14991
hydroxycarboxylic acid receptors and related proteins, member of the class A family of ...
21-320 6.67e-07

hydroxycarboxylic acid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the hydroxycarboxylic acid receptors (HCARs) as well as their closely related receptors, GPR31 and oxoeicosanoid receptor 1 (OXER1). HCARs are members of the class A family of G-protein coupled receptors (GPCRs). HCAR subfamily contain three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2, orGPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. All three HCA receptors are expressed in adipocytes, and are coupled to G(i)-proteins mediating anti-lipolytic effects in fat cells. OXER1 is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid, whereas GPR31 is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12-S-HETE).


Pssm-ID: 320122 [Multi-domain]  Cd Length: 280  Bit Score: 50.52  E-value: 6.67e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  21 VLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIKTNYFiVSLAFADLLVSVlVMPFGAIELVQ-DIWFYGEMFCLVRTSL 99
Cdd:cd14991     2 ILPPLLILEFVLGLPGNVVALWIFCFHSRTWKANTVYL-FNLVLADFLLLI-CLPFRIDYYLRgEHWIFGEAWCRVNLFM 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 100 DVLLTTASIFHLCCISLDRYYAICcQPLVYRNKMTPLRIALMLGGCWVIPMFISfLPIMqgwnnigIVDVIEKrkfnhNS 179
Cdd:cd14991    80 LSVNRSASIAFLTAVALDRYFKVV-HPHHRVNRMSVKAAAGVAGLLWALVLLLT-LPLL-------LSTLLTV-----NS 145
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 180 NSTFC--VFMVNKPYAI-----TCSVVAFYIPFLLMVLAYYRIYVTAKehaqqiqmlQRAGATSESRPQtadqhsthrmr 252
Cdd:cd14991   146 NKSSChsFSSYTKPSLSirwhnALFLLEFFLPLGLIVFCSVRIACNLR---------IRQSLGKQARVQ----------- 205
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1938531436 253 tetKAAKTLCVIMGCFCFCWAPFFVTN----IVDPFIDYTVPEKVWTAF---LWLGYINSGLNPFLYAFLNKSFR 320
Cdd:cd14991   206 ---RAIRLVFLVVIVFVLCFLPSIIAGllalVFKNLGSCRCLNSVAQLFhisLAFTYLNSALDPVIYCFSSPWFR 277
7tmA_PGE2_EP4 cd15142
prostaglandin E2 receptor EP4 subtype, member of the class A family of seven-transmembrane G ...
23-124 8.10e-07

prostaglandin E2 receptor EP4 subtype, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin E2 receptor EP4, also called prostanoid EP4 receptor, is one of four receptor subtypes whose endogenous physiological ligand is prostaglandin E2 (PGE2). Each of these subtypes (EP1-EP4) have unique but overlapping tissue distributions that activate different intracellular signaling pathways. Like the EP2 receptor, stimulation of the EP4 receptor by PGE2 causes cAMP accumulation through G(s) protein activation. Knockout studies in mice suggest that EP4 receptor may be involved in the maintenance of bone mass and fracture healing. Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320270 [Multi-domain]  Cd Length: 302  Bit Score: 50.19  E-value: 8.10e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  23 LTFFAMVILMAILGNLLVMVAVCRDRQLRKIKTNYFIV-SLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSLDV 101
Cdd:cd15142     4 PTIPAVMFIFGVVGNLIAIVVLCKSRKEQKETTFYTLVcGLAVTDLLGTCLASPVTIATYLKGRWPGGQPLCEYFSFILL 83
                          90       100
                  ....*....|....*....|...
gi 1938531436 102 LLTTASIFHLCCISLDRYYAICC 124
Cdd:cd15142    84 FFSLSGLSIICAMSIERYLAINH 106
7tmA_P2Y3-like cd16001
P2Y purinoceptor 3-like proteins, member of the class A family of seven-transmembrane G ...
26-321 8.60e-07

P2Y purinoceptor 3-like proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y3-like proteins are an uncharacterized group that belongs to the G(i) class of a family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320667 [Multi-domain]  Cd Length: 284  Bit Score: 50.14  E-value: 8.60e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  26 FAMVILMAILGNLLVMVAVCRdRQLRKIKTNYFIVSLAFADLLVsVLVMPFGAIE-LVQDIWFYGEMFC-LVRTSLDVLL 103
Cdd:cd16001     7 YSVVFVLGLPLNGTVLWLSWC-RTKRWTCSTIYLVNLAVADLLY-VCSLPLLIVNyAMRDRWPFGDFLCkLVRFLFYTNL 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 104 TtASIFHLCCISLDRYYAIC--CQPLVYRNKMTPL---RIALMLGGCWVIPMFIsflpimqgWNNIGIVDviekrkfnhn 178
Cdd:cd16001    85 Y-GSILFLTCISVHRFLGVCypIRSLAYRTRRLAVigsAATWILVVLQLLPTLV--------YARTGSIN---------- 145
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 179 sNSTFCVFMVNK-------PYAITCSVVAFYIPFLLMVLAYYRIyvtakehaqqIQMLQRAGatsesrpQTADQHSTHRm 251
Cdd:cd16001   146 -NRTVCYDLTSPdnfgnyfPYGMVLTVTGFLIPFLIILLCYCLM----------IKSLIRSE-------EAAGVGKAAR- 206
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 252 rteTKAAKTLCVIMGCFCFCWAPFFVTNIVDPFIDY------------TVPEKVWTAFLWLgyiNSGLNPFLYAFLNKSF 319
Cdd:cd16001   207 ---AKSIRTILLVCGLFALCFVPFHITRTIYLFVRVylvqdcpllqfvSLAYKIWRPLVSF---NSCINPLLYFLSGDSN 280

                  ..
gi 1938531436 320 RR 321
Cdd:cd16001   281 RL 282
7tmA_GPR34-like cd15148
putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G ...
20-322 9.24e-07

putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 34 of unknown function. Orphan GPR34 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320276 [Multi-domain]  Cd Length: 282  Bit Score: 50.08  E-value: 9.24e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQlRKIKTNYFIVSLAFADLLVsVLVMPFGAI-ELVQDIWFYGEMFCLVRTS 98
Cdd:cd15148     1 LPLAVFYSLIFLFGLVGNLLALWVFLFIHR-KRNSVRIFLINVAIADLLL-IICLPFRILyHVNNNQWTLGPLLCKVVGN 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  99 LDVLLTTASIFHLCCISLDRYYAIccQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPimqgwnnigivdVIEKRKFNHN 178
Cdd:cd15148    79 LFYMNMYISIILLGFISLDRYLKI--NRSSRRQKFLTRKWSIVACGVLWAVALVGFVP------------MIVLTEKNEE 144
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 179 SNSTFCVFMVN----KPYAITCSVVAFYIPFLLMVLAYYRIyvtAKEhaqqiqmLQRAgatSESRPQTADQHSTHRmrte 254
Cdd:cd15148   145 STKCFQYKDRKnakgKAIFNFLIVAMFWLVFLLLILSYGKI---AKK-------LLRI---SRDKPDFPNAAKYNR---- 207
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1938531436 255 tkAAKTLCVIMGCFCFCWAP------FFVTNIVDPFIDYT--VPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRA 322
Cdd:cd15148   208 --TARKSFFVLFIFTVCFVPyhafriFYITSQLQNNSCYWkeILHKTNEIMLLLSAFNSCLDPVMYFLLSSSIRKV 281
7tmA_CCR5_CCR2 cd15184
CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G ...
21-321 1.03e-06

CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR2 and CCR5 share very high amino acid sequence identity. Both receptors play important roles in the trafficking of monocytes/macrophages and are implicated in the pathogenesis of immunologic diseases (rheumatoid arthritis, celiac disease, and transplant rejection) and cardiovascular diseases (atherosclerosis and autoimmune hepatitis). CCR2 is a receptor specific for members of the monocyte chemotactic protein family, including CCL2, CCL7, and CCL13. Conversely, CCR5 is a major co-receptor for HIV infection and binds many CC chemokine ligands, including CC chemokine ligands including CCL2, CCL3, CCL4, CCL5, CCL11, CCL13, CCL14, and CCL16. CCR2 is expressed primarily on blood monocytes and memory T cells, whereas CCR5 is expressed on antigen-presenting cells (macrophages and dendritic cells) and activated T effector cells. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341338 [Multi-domain]  Cd Length: 278  Bit Score: 49.75  E-value: 1.03e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  21 VLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIkTNYFIVSLAFADLLVsVLVMPFGAIELVQDiWFYGEMFCLVRTSLD 100
Cdd:cd15184     2 LLPPLYSLVFIFGFVGNMLVVLILINCKKLKSM-TDIYLLNLAISDLLF-LLTLPFWAHYAANE-WVFGNAMCKLLTGLY 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 101 VLLTTASIFHLCCISLDRYYAICcqPLVYRNKMTPLRIALMLGG-CWVIPMFISFLPImqgwnnigIVDVIEKRKFNHNS 179
Cdd:cd15184    79 HIGFFSGIFFIILLTIDRYLAIV--HAVFALKARTVTFGVVTSVvTWVVAVFASLPGI--------IFTKSQKEGSHYTC 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 180 NSTF---CVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKehaqqiqmlqragatsesrpqtadqhSTHRMRTETK 256
Cdd:cd15184   149 SPHFppsQYQFWKNFQTLKMNILGLVLPLLVMIICYSGILKTLL--------------------------RCRNEKKRHK 202
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1938531436 257 AAKTLCVIMGCFCFCWAPFFVTNIVDPFID---------YTVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRR 321
Cdd:cd15184   203 AVRLIFTIMIVYFLFWAPYNIVLLLNTFQEffglnncssSNRLDQAMQVTETLGMTHCCINPVIYAFVGEKFRS 276
7tmA_OR10G6-like cd15942
olfactory receptor subfamily 10G6 and related proteins, member of the class A family of ...
22-145 1.10e-06

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10G6 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320608  Cd Length: 275  Bit Score: 49.74  E-value: 1.10e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  22 LLTFFAMVILMAILGNLLVMVAVCRDRQLRKiKTNYFIVSLAFADLLVSVLVMP---FGAIELVQDIWFYGemfCLVRTS 98
Cdd:cd15942     3 LFLFFLVVYLLTLSGNSLIILVVISDLQLHK-PMYWFLCHLSILDMAVSTVVVPkviAGFLSGGRIISFGG---CVTQLF 78
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1938531436  99 LDVLLTTASIFHLCCISLDRYYAIcCQPLVYRNKMT-----PLRIALMLGGC 145
Cdd:cd15942    79 FFHFLGCAECFLYTVMAYDRFLAI-CKPLHYSTIMNhraclCLSLGTWLGGC 129
7tmA_OR2T-like cd15421
olfactory receptor subfamily 2T and related proteins, member of the class A family of ...
21-155 1.16e-06

olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 2T, 2M, 2L, 2V, 2Z, 2AE, 2AG, 2AK, 2AJ, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320543  Cd Length: 277  Bit Score: 49.47  E-value: 1.16e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  21 VLLTFFAMVILMAILGNLLVMVAVCRDRQLRKikTNYFIVS-LAFADL-LVSVLV--MPFGAIELVQDIWFYGemfCLVR 96
Cdd:cd15421     2 FLFSLILLIFLVALTGNALLILLIWLDSRLHT--PMYFLLSqLSLMDLmLISTTVpkMATNFLSGRKSISFVG---CGTQ 76
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1938531436  97 TSLDVLLTTASIFHLCCISLDRYYAICCqPLVYRNKMTPLRIALMLGGCWVIPMFISFL 155
Cdd:cd15421    77 IFFFLTLGGAECLLLALMAYDRYVAICH-PLRYPVLMSPRVCLLMAAGSWLGGSLNSLI 134
7tmA_GPR35_55-like cd15923
G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of ...
23-323 1.20e-06

G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily is composed of GPR35, GPR55, and similar proteins. GPR35 shares closest homology with GPR55, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A number of studies have suggested that GPR35 may play important physiological roles in hypertension, atherosclerosis, nociception, asthma, glucose homeostasis and diabetes, and inflammatory bowel disease. GPR35 is thought to be responsible for brachydactyly mental retardation syndrome, which is associated with a deletion comprising chromosome 2q37 in human, and is also implicated as a potential oncogene in stomach cancer. GPR35 couples to G(13) and G(i/o) proteins, whereas GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Recently, lysophosphatidylinositol (LPI) has been identified as an endogenous ligand for GPR55, while several endogenous ligands for GPR35 have been identified including kynurenic acid, 2-oleoyl lysophosphatidic acid, and zaprinast.


Pssm-ID: 320589 [Multi-domain]  Cd Length: 273  Bit Score: 49.38  E-value: 1.20e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  23 LTFFAMVILMAILGNLLVMVAV----CRDRQlrKIKTNYFIVSLAFADLLVsVLVMPFgAIELVQDIWFYGEMFCLVRTS 98
Cdd:cd15923     1 LLQYAIYIPTFVLGLLLNILALwvfcWRLKK--WTETNIYMTNLAVADLLL-LISLPF-KMHSYRRESAGLQKLCNFVLS 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  99 LDVLLTTASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVIPMFISflpimqgwnnigivdvIEKRKFNHN 178
Cdd:cd15923    77 LYYINMYVSIFTITAISVDRYVAI-RYPLRARELRSPRKAAVVCAVIWVLVVTIS----------------IPYFLLDSS 139
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 179 SNSTFCVFMVNKPYAITCS----VVAFYIPFLLMVLAYYRIyvtakehaqqIQMLQRAGATSESRPQTadqhsthrMRTE 254
Cdd:cd15923   140 NEKTMCFQRTKQTESLKVFllleIFGFLLPLIIMTFCSARV----------IHTLQKRLDDVGSRSET--------KQCI 201
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1938531436 255 TKAAKTLCVIMGCFCFCWAPFFVTNIVDPFIDYTVPEKVWTAF---LWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15923   202 RVIMANLIVFIVCFLPVHVGFFVKFIVGKSYSCDSKLIIHFFLqsaFCLSDMNCCLDAFCYYFATKEFREAY 273
7tmA_SWS2_opsin cd15077
short wave-sensitive 2 opsins, member of the class A family of seven-transmembrane G ...
21-320 1.56e-06

short wave-sensitive 2 opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Short Wave-Sensitive opsin 2 (SWS2), which mediates visual transduction in response to light at short wavelengths (violet to blue). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320205 [Multi-domain]  Cd Length: 280  Bit Score: 49.06  E-value: 1.56e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  21 VLLTFFAMVILMAILGNLLVMVAVCRDRQLRKiKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSLD 100
Cdd:cd15077     2 GMSAFMLFLVIAGFPINVLTIICTIKYKKLRS-HLNYILVNLAVANLIVVCFGSTTAFYSFSQMYFVLGPLACKIEGFTA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 101 VLLTTASIFHLCCISLDRYYAIcCQPL---VYRNKMTPLRIALMlggcWVIPmFISFLPIMQGWN---------NIGIVD 168
Cdd:cd15077    81 TLGGMVSLWSLAVVAFERFLVI-CKPLgnfTFRGTHAIIGCIAT----WVFG-LAASLPPLFGWSryipeglqcSCGPDW 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 169 VIEKRKFNhnsnstfcvfmvNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAQQiqmlQRAGATSEsrpqtadqhst 248
Cdd:cd15077   155 YTTNNKWN------------NESYVMFLFCFCFGVPLSIIVFSYGRLLLTLRAVAKQ----QEQSASTQ----------- 207
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1938531436 249 hrmRTETKAAKTLCVIMGCFCFCWAPFFVtnivdpFIDYTVPEKVWTAFLWLGYINSGL-------NPFLYAFLNKSFR 320
Cdd:cd15077   208 ---KAEREVTKMVVVMVLGFLVCWLPYAS------FALWVVTNRGEPFDLRLASIPSVFskastvyNPVIYVFMNKQFR 277
7tmA_PAR3 cd15371
protease-activated receptor 3, member of the class A family of seven-transmembrane G ...
24-317 1.73e-06

protease-activated receptor 3, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320493 [Multi-domain]  Cd Length: 274  Bit Score: 49.02  E-value: 1.73e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  24 TFFAMVILMAILGNLLVMVAVCRdrQLRKIKTNYFIVSLAFADLLVsVLVMPFG-AIELVQDIWFYGEMFCLVRTSLDVL 102
Cdd:cd15371     5 AVYIIVVVLGVPSNAIILWMLFF--RLRSVCTAIFYANLAISDLLF-CITLPFKiVYHLNGNNWVFGETMCRIITITFYG 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 103 LTTASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVIpMFISFLP--IMQGWNNIGIVDVIEKRKFNHNSN 180
Cdd:cd15371    82 NMYCSILLLTCISINRYLAI-VHPFIYRSLPKKTYAVLICALVWTI-VFLYMLPffILKQTYYLKELNITTCHDVLPECE 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 181 STFCVFMVnkpYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHaqqiqmlqragatsesrpqtadqhsTHRMRTETKAAKT 260
Cdd:cd15371   160 QNSNFQFY---YFISMAVFGFLIPLVITIFCYISIIRTLNAY-------------------------EHKWFWYVKITAL 211
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1938531436 261 LCVImgcFCFCWAPFFVTNIVDPFIDYTVPE----KVWTAFLWLGYINSGLNPFLYAFLNK 317
Cdd:cd15371   212 VLII---FTICFAPSNVILIIHHFNYYYFNNdnlySIYLIALCLGSLNSCLDPFLYFLMSK 269
7tmA_HCAR1-3 cd15201
hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G ...
21-323 1.92e-06

hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Hydroxycarboxylic acid receptor (HCAR) subfamily, a member of the class A G-protein coupled receptors (GPCRs), contains three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, or nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2 or GPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. Because nicotinic acid is capable of stimulating HCAR2 at higher concentrations only (in the range of sub-micromolar concentration), it is unlikely that nicotinic acts as a physiological ligand of HCAR2. All three receptors are expressed in adipocytes and mediate anti-lipolytic effects in fat cells through G(i) type G protein-dependent inhibition of adenylate cyclase.


Pssm-ID: 320329 [Multi-domain]  Cd Length: 281  Bit Score: 48.89  E-value: 1.92e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  21 VLLTFFAMVILMAILGNLLVMVAVCRdrQLRKIKTN-YFIVSLAFADLLVSVlVMPFGAIELVQDI-WFYGEMFCLVRTS 98
Cdd:cd15201     2 VLPPVLILEFVLGLLGNGLALWIFCF--HLKSWKSStVYLFNLAVADFLLII-CLPFRTDYYLRGKhWKFGDIPCRIVLF 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  99 LDVLLTTASIFHLCCISLDRYYAICcQPLVYRNKMTPLRIALMLGGCWVIPMfisflpimqgwnnIGIVDVIEKRKFNHN 178
Cdd:cd15201    79 MLAMNRAGSIFFLTAVAVDRYFRVV-HPHHRINSISVRKAAIIACGLWLLTI-------------AMTVYLLTKKHLFPR 144
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 179 SNSTFCV-FMVNKPYAITCS------VVAFYIPFLLMVLAYYRIyvtakehaqqiqmlqragaTSESRPQTADQHSthRM 251
Cdd:cd15201   145 GNATQCEsFNICTGTDSSSNwheamfLLEFFLPLAIILYCSVRI-------------------IWQLRGRQLDRHA--KI 203
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 252 RtetKAAKTLCVIMGCFCFCWAPFFVTNIV------DPFIDYTVPEKVWTAF---LWLGYINSGLNPFLYAFLNKSFRRA 322
Cdd:cd15201   204 K---RAVQFIMVVAIVFIICFLPSNVTRIAiwilkhTSNEDCQYYRSVDLAFyitISFTYFNSMLDPVVYYFSSPSFKNF 280

                  .
gi 1938531436 323 F 323
Cdd:cd15201   281 Y 281
7tmA_OR10A-like cd15225
olfactory receptor subfamily 10A and related proteins, member of the class A family of ...
20-218 2.33e-06

olfactory receptor subfamily 10A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10A, 10C, 10H, 10J, 10V, 10R, 10J, 10W, among others, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320353  Cd Length: 277  Bit Score: 48.61  E-value: 2.33e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRkIKTNYFIVSLAFADLLVSVLVMPFGAIELV---QDIWFYG---EMFC 93
Cdd:cd15225     1 LLLFVVFLLIYLVTLLGNLLIILITKVDPALH-TPMYFFLRNLSFLEICYTSVIVPKMLVNLLsedKTISFLGcatQMFF 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  94 LVrtsldvLLTTASIFHLCCISLDRYYAICcQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMQ-------GWNNIgi 166
Cdd:cd15225    80 FL------FLGGTECFLLAAMAYDRYVAIC-NPLRYTLIMNRRVCLQLVAGSWLSGILVSLGQTTLifslpfcGSNEI-- 150
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1938531436 167 vdviekrkfNHnsnsTFC----VFM-------VNKPYAITCSVVAFYIPFLLMVLAYYRIYVT 218
Cdd:cd15225   151 ---------NH----FFCdippVLKlacadtsLNEIAIFVASVLVILVPFLLILVSYIFIIST 200
7tmA_OR4D-like cd15936
olfactory receptor 4D and related proteins, member of the class A family of ...
21-147 2.49e-06

olfactory receptor 4D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320602 [Multi-domain]  Cd Length: 267  Bit Score: 48.48  E-value: 2.49e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  21 VLLTFFAMVILMAILGNLLVMVAVCRDRQLRkIKTNYFIVSLAFADLLVSVLVMPFGAIELVQD---IWFYGemfCLVRT 97
Cdd:cd15936     2 FLFLVFLLVYLTTWLGNLLIIITVISDPHLH-TPMYFLLANLAFLDISFSSVTAPKMLSDLLSQtktISFNG---CMAQM 77
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1938531436  98 SLDVLLTTASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWV 147
Cdd:cd15936    78 FFFHFTGGAEVFLLSVMAYDRYIAI-HKPLHYLTIMNQGVCTGLVAGSWL 126
7tmA_OR5H-like cd15409
olfactory receptor subfamily 5H and related proteins, member of the class A family of ...
20-135 2.49e-06

olfactory receptor subfamily 5H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5H, 5K, 5AC, 5T and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320531 [Multi-domain]  Cd Length: 279  Bit Score: 48.56  E-value: 2.49e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRkIKTNYFIVSLAFADLLVSVLVMPFGAIELV---QDIWFYGemfCLVR 96
Cdd:cd15409     1 VPLFLVFLAIYLITLVGNLGLIALIWKDSHLH-TPMYFFLGNLAFADACTSSSVTPKMLVNFLsknKMISFSG---CAAQ 76
                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1938531436  97 TSLDVLLTTASIFHLCCISLDRYYAIcCQPLVYRNKMTP 135
Cdd:cd15409    77 FFFFGFSATTECFLLAAMAYDRYVAI-CNPLLYPVVMSN 114
7tmA_OR2D-like cd15428
olfactory receptor subfamily 2D and related proteins, member of the class A family of ...
20-153 2.66e-06

olfactory receptor subfamily 2D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320545 [Multi-domain]  Cd Length: 277  Bit Score: 48.63  E-value: 2.66e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKiKTNYFIVSLAFADLLVSVLVMPFGAIELVQD---IWFYGemfCLVR 96
Cdd:cd15428     1 ILLFILFLIIYLMTVLGNLLLVLLVIVDSHLHT-PMYFFLSNLSVLELCYTTTVVPQMLVHLLSErkiISFIR---CAAQ 76
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1938531436  97 TSLDVLLTTASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVIPMFIS 153
Cdd:cd15428    77 LYFFLSFGITECALLSVMSYDRYVAI-CLPLRYSLIMTWKVCISLATGSWVGGLLVS 132
7tmA_P2Y8 cd15368
purinergic receptor P2Y8, member of the class A family of seven-transmembrane G ...
20-323 2.99e-06

purinergic receptor P2Y8, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320490 [Multi-domain]  Cd Length: 281  Bit Score: 48.23  E-value: 2.99e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRdRQLRKIKTNYFIVSLAFADLLVsVLVMPFGAIELVQ-DIWFYGEMFCLVRTS 98
Cdd:cd15368     1 VILPVVYSLVALISIPGNLFSLWLLCF-HTKPKTPSIIFMINLSLTDLML-ACFLPFQIVYHIQrNHWIFGKPLCNVVTV 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  99 LDVLLTTASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVIPMFIsFLPIMQG-----WNNIGIVDVIEKR 173
Cdd:cd15368    79 LFYANMYSSILTMTCISIERYLGV-VYPMRSMRWRKKRYAVAACIGMWLLVLTA-LSPLERTdltyyVKELNITTCFDVL 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 174 KFNHNSNstfcvFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYvtakehaqqIQMLQRAGATSESRpqtadqhsthrmrt 253
Cdd:cd15368   157 KWTMLPN-----IAAWAAFLFTLFILLFLIPFIITVYCYVLII---------LKLVQTSERYGREQ-------------- 208
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1938531436 254 ETKAAKTLCVIMGCFCFCWAP----FFVTNIVDPFIDYTVpEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15368   209 KRRAIYLALIVLLVFITCFAPnnfiLLAHMVSRLFYGKSL-YHAYKLTLSLSCLNSCLDPFIYYFASKEFRKKL 281
7tmA_LPAR6_P2Y5 cd15156
lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G ...
26-281 3.68e-06

lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 6 (LPAR6), also known as P2Y5, is a G(i), G(12/13) G protein-coupled receptor that is activated by the bioactive lipid lysophosphatidic acid (LPA), which is released by activated platelets and constitutively present in serum. LPAR6 plays an important role in maintenance of human hair growth. Thus, mutations in the receptor are responsible for both autosomal recessive wooly hair and hypotrichosis. Phylogenetic analysis of the class A GPCRs shows that LAPR6 (P2Y5) is classified into the cluster consisting of receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production.


Pssm-ID: 320284 [Multi-domain]  Cd Length: 285  Bit Score: 48.31  E-value: 3.68e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  26 FAMVILMAILGNLLVMVAVCRDRQLRKIKTNYFIvSLAFADLLVsVLVMPFGAIELVQDIWFYGEMFCLVRTSLDVLLTT 105
Cdd:cd15156     7 FSMVFVLGLIANCVAIYIFMCTLKVRNETTTYMI-NLAISDLLF-VFTLPFRIFYFVQRNWPFGDLLCKISVTLFYTNMY 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 106 ASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVIPMFISF-LPIMQGWNNigivdviekrKFNHNSNSTFC 184
Cdd:cd15156    85 GSILFLTCISVDRFLAI-VYPFRSKTLRTKRNAKIVCAAVWLTVLAGSLpASFFQSTNN----------QLNNNSETCFE 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 185 VFMVN--KPY----AITCSVVAFYIPFLLMVLAyyriyvtakeHAQQIQMLQRAGATSESRpqtadqhsthrmRTETKAA 258
Cdd:cd15156   154 NFSSKtwKTYlskiVIFIEIVGFFIPLILNVTC----------STMVLKTLRRPNTLSRSK------------LNKKKVL 211
                         250       260
                  ....*....|....*....|...
gi 1938531436 259 KTLCVIMGCFCFCWAPFFVTNIV 281
Cdd:cd15156   212 KMIFVHLFIFCFCFIPYNVNLVL 234
7tmA_GPR37 cd15127
G protein-coupled receptor 37, member of the class A family of seven-transmembrane G ...
27-121 3.70e-06

G protein-coupled receptor 37, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR37, also called parkin-associated endothelin-like receptor (Pael-R), was isolated from a set of human brain frontal lobe expressed sequence tags. It is highly expressed in the mammalian CNS. It is a substrate of parkin and is involved in the pathogenesis of Parkinson's disease. GPR37 has recently been shown to act as a receptor for the neuropeptide prosaptide, the active fragment of the secreted neuroprotective and glioprotective factor prosaposin (also called sulfated glycoprotein-1). Both prosaptide and prosaposin protect primary astrocytes against oxidative stress. GPR37 is part of the class A family of GPCRs that includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320255 [Multi-domain]  Cd Length: 298  Bit Score: 48.31  E-value: 3.70e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  27 AMVILMAILGNLLVMVAVCRDRQLRKIkTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSLDVLLTTA 106
Cdd:cd15127     8 VVIFGIGIMGNVAVMCIVCHNYYMRSI-SNSLLANLAFWDFLIIFFCLPLVIFHELTKKWLLGDFSCKIVPYIEVASLGV 86
                          90
                  ....*....|....*
gi 1938531436 107 SIFHLCCISLDRYYA 121
Cdd:cd15127    87 TTFTLCALCIDRFRA 101
7tmA_P2Y11 cd15376
P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled ...
31-215 4.71e-06

P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y11 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. The activation of P2Y11 is a major pathway of macrophage activation that leads to the release of cytokines. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320498 [Multi-domain]  Cd Length: 284  Bit Score: 47.77  E-value: 4.71e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  31 LMAILGNLLVM-VAVCRDRQLRKIKTnYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSLDVLLTTASIF 109
Cdd:cd15376    12 LVAVLGNGLALwLFVTRERRPWHTGV-VFSFNLAVSDLLYALSLPLLAAYYYPPKNWRFGEAACKLERFLFTCNLYGSIF 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 110 HLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVIPMFISfLPIMQgwnnigiVDVIEKRKfnhnSNSTFCVFMVN 189
Cdd:cd15376    91 FITCISLNRYLGI-VHPFFTRSHVRPKHAKLVSLAVWLLVAALS-APVLS-------FSHLEVER----HNKTECLGTAV 157
                         170       180       190
                  ....*....|....*....|....*....|...
gi 1938531436 190 K-------PYAITCSVVAFYIPFLLMVLAYYRI 215
Cdd:cd15376   158 DsrlptylPYSLFLAVVGCGLPFLLTLASYLAI 190
7tmA_PAFR cd15147
platelet-activating factor receptor, member of the class A family of seven-transmembrane G ...
25-321 5.27e-06

platelet-activating factor receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The platelet-activating factor receptor is a G(q/11)-protein coupled receptor, which is linked to p38 MAPK and PI3K signaling pathways. PAF is a phospholipid (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) which is synthesized by cells especially involved in host defense such as platelets, macrophages, neutrophils, and monocytes. PAF is well-known for its ability to induce platelet aggregation and anaphylaxis, and also plays important roles in allergy, asthma, and inflammatory responses, among many others.


Pssm-ID: 320275 [Multi-domain]  Cd Length: 291  Bit Score: 47.82  E-value: 5.27e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  25 FFAMVILMAILGNLLVMVAVCR---DRQLRKIKTnyFIVSLAFADLLVsVLVMPFGAIELV-QDIWFYGEMFCLVRTSLD 100
Cdd:cd15147     6 VYSIIFVLGLIANCYVLWVFARlypSKKLNEIKI--FMVNLTIADLLF-LITLPFWIVYYHnEGNWILPKFLCNVAGCLF 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 101 VLLTTASIFHLCCISLDRYYAICcQPLVYRNKMTPLRIALMLGGCWVI--PMFISFLpIMQGWNNIGIVDVIEKRKFNHN 178
Cdd:cd15147    83 FINTYCSVAFLGVISYNRYQAVT-RPIKTAQSTTRKRGIIISVAIWVIivASASYFL-FMDSTNTVKIDSGNFTRCFEGY 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 179 SNSTfcvfmvNKPYAIT--CSVVAFYIPFLLMVLAYYRIyvtakehaqqIQMLQRagatsesrpQTADQHSTHRMRTetK 256
Cdd:cd15147   161 EKDN------SKPVLIIhfIIIGLFFLVFLLILVCNLVI----------ARTLLS---------QPVQGQRNAGVKR--R 213
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1938531436 257 AAKTLCVIMGCFCFCWAPFFVTNIVDPFIDYTVPEKVWTAF-----------LWLGYINSGLNPFLYAFLNKSFRR 321
Cdd:cd15147   214 ALWMVCTVLAVFVICFVPHHVVQGPWTLAVLQQWRYWDCQFrqalndahqitLCLMSTNCVLDPVIYCFLTKKFRK 289
7tmA_LHCGR cd15359
luteinizing hormone-choriogonadotropin receptor, member of the class A family of ...
31-323 5.35e-06

luteinizing hormone-choriogonadotropin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. LHCGR is expressed predominantly in the ovary and testis, and plays an essential role in sexual development and reproductive processes. LHCGR couples primarily to the G(s)-protein and activates adenylate cyclase, thereby promoting cAMP production.


Pssm-ID: 320481 [Multi-domain]  Cd Length: 275  Bit Score: 47.55  E-value: 5.35e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  31 LMAILGNLLVMVAVCRDRQLRKIKtNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMF-------CLVRTSLDVLL 103
Cdd:cd15359    12 ILAIAGNLIVLFVLLTSRYKLTVP-RFLMCNLSFADFCMGLYLLLIASVDSQTKSQYYNHAIdwqtgsgCSTAGFFTVFA 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 104 TTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGcWVIPMFISFLPImqgwnnIGIVDVIEkrkfnhnsnSTF 183
Cdd:cd15359    91 SELSVYTLTVITLERWHTITYAMQLDRKLRLRHAILIMLGG-WVFSLLIAVLPL------VGVSNYMK---------VSI 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 184 CVFM-----VNKPYAITCSVVAFyIPFLLMVLAYYRIYVTAkehaqqiqmlqragatsesrpQTADQHSTHRmrtETKAA 258
Cdd:cd15359   155 CLPMdietlLSQAYILLILVLNV-IAFLVICACYIKIYLAV---------------------QNPELVAKNK---DTKIA 209
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1938531436 259 KTLCVIMGCFCFCWAP--FFVTN--IVDPFIDYTVPEKVWTAFLwlgYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15359   210 KRMAILIFTDFTCMAPisFFAISaaFKVPLITVTNSKILLVLFY---PINSCANPFLYAIFTKAFRRDF 275
7tmA_OR4-like cd15226
olfactory receptor family 4 and related proteins, member of the class A family of ...
21-148 5.50e-06

olfactory receptor family 4 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 4 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320354 [Multi-domain]  Cd Length: 267  Bit Score: 47.58  E-value: 5.50e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  21 VLLTFFAMVILMAILGNLLVMVAVCRDRQLRKikTNYFIVS-LAFADLLVSVLVMPFGAIELVQD---IWFYGemfCLVR 96
Cdd:cd15226     2 FLFVFFSLFYVATVLGNLLIVVTVTSDPHLHS--PMYFLLAnLSFIDLCLSSFATPKMICDLLREhktISFGG---CMAQ 76
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1938531436  97 TSLDVLLTTASIFHLCCISLDRYYAICcQPLVYRNKMTPLRIALMLGGCWVI 148
Cdd:cd15226    77 IFFLHFFGGSEMVLLIAMAFDRYVAIC-KPLHYLTIMSPRMCILLVVASWII 127
7tmA_OR10S1-like cd15941
olfactory receptor subfamily 10S1 and related proteins, member of the class A family of ...
21-148 5.67e-06

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10S1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320607 [Multi-domain]  Cd Length: 277  Bit Score: 47.54  E-value: 5.67e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  21 VLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELV----QDIWFYGemfCLVR 96
Cdd:cd15941     2 LFFLLFLLIYLLTVLGNLLILLTIGSDPHLHGLPMYHFLGHLSFLDACLSSVTVPKVLAGLLtlsgRTISFEG---CVVQ 78
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1938531436  97 TSLDVLLTTASIFHLCCISLDRYYAICcQPLVYRNKMTPLRIALMLGGCWVI 148
Cdd:cd15941    79 LYAFHFLASTECFLYTVMAYDRYLAIC-HPLHYPTAMNRRMCAGLAGGTWAT 129
7tmA_FSH-R cd15360
follicle-stimulating hormone receptor, member of the class A family of seven-transmembrane G ...
21-323 5.67e-06

follicle-stimulating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. FSH-R functions in gonad development and is found in the ovary, testis, and uterus. Defects in this receptor cause ovarian dysgenesis type 1, and also ovarian hyperstimulation syndrome. The FSH-R activation couples to the G(s)-protein and stimulates adenylate cyclase, thereby promoting cAMP production.


Pssm-ID: 320482  Cd Length: 275  Bit Score: 47.55  E-value: 5.67e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  21 VLLTFFAMVILMAILGNLLVMVaVCRDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMF-------C 93
Cdd:cd15360     2 ILRVLIWFINILAITGNIVVLA-ILLTSQYKLTVPRFLMCNLAFADLCMGIYLLLIASVDIRTKSQYYNYAIdwqtgagC 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  94 LVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGcWVIPMFISFLPIMqGWNNIGIVDVIEKR 173
Cdd:cd15360    81 AAAGFFTVFASELSVYTLTVITLERWHTITYAMQLDRKVRLRHAAVIMVGG-WIFAFTVALLPIF-GISSYMKVSICLPM 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 174 KFNHNSNSTFCVFMvnkpyaitcsVVAFYIPFLLMVLAYYRIYVTAKEhaqqiqmlqragatsesrPQTADQHSthrmrt 253
Cdd:cd15360   159 DIESPLSQAYIIFI----------LVLNVLAFLIICACYIKIYLTVRN------------------PNFVSSNS------ 204
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1938531436 254 ETKAAKTLCVIMGCFCFCWAPFFVTNIVDPFIDYTVPEKVWTAFLWLGY-INSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15360   205 DTKIAKRMAVLIFTDFLCMAPISFFAISASLKVPLITVSKSKILLVLFYpINSCANPFLYAIFTKTFRRDF 275
7tmA_OR51-like cd15222
olfactory receptor family 51 and related proteins, member of the class A family of ...
23-157 5.84e-06

olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 51 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320350  Cd Length: 275  Bit Score: 47.50  E-value: 5.84e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  23 LTFFAMViLMAILGNLLVMVAVCRDRQLRKiKTNYFIVSLAFADLLVSVLVMP-------FGAIELVQDIWFyGEMFCLV 95
Cdd:cd15222     5 IPFCLLY-LVALLGNSTILFVIKTEPSLHE-PMYYFLSMLAVTDLGLSLSTLPtvlgifwFNAREISFDACL-AQMFFIH 81
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1938531436  96 RTSL---DVLLTTAsifhlccisLDRYYAICCqPLVYRNKMTPLRIALMlGGCWVIPMFISFLPI 157
Cdd:cd15222    82 TFSFmesSVLLAMA---------FDRFVAICN-PLRYASILTNSRIAKI-GLAIVLRSVLLLLPL 135
7tmA_CX3CR1 cd15186
CX3C chemokine receptor 1, member of the class A family of seven-transmembrane G ...
20-321 5.86e-06

CX3C chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; CX3CR1 is an inflammatory receptor specific for CX3CL1 (also known as fractalkine in human), which is involved in the adhesion and migration of leukocytes. The CX3C chemokine subfamily is only represented by CX3CL1, which exists in both soluble and membrane-anchored forms. Membrane-anchored form promotes strong adhesion of receptor-bearing leukocytes to CX3CL1-expressing endothelial cells. On the other hand, soluble CX3CL1, which is released by the proteolytic cleavage of membrane-anchored CX3CL1, is a potent chemoattractant for CX3CR1-expressing T cells and monocytes. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 320314 [Multi-domain]  Cd Length: 273  Bit Score: 47.52  E-value: 5.86e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIkTNYFIVSLAFADLLVsVLVMPFGAIELVQDiWFYGEMFCLVRTSL 99
Cdd:cd15186     1 IFLSIFYSLVFAFGLVGNLLVVLALTNSGKSKSI-TDIYLLNLALSDLLF-VATLPFWTHYLINE-WGLHNAMCKLTTAF 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 100 DVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLgGCWVIPMFISFLPIM--QGWNNIGIVDVIEKRKfnh 177
Cdd:cd15186    78 FFIGFFGGIFFITVISIDRYLAIVLAANSMNNRTVQHGVTISL-GVWAAAILVAVPQFMftKMKENECLGDYPEVLQ--- 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 178 NSNSTFCVFMVNkpyaitcsVVAFYIPFLLMVLAYYRIyvtakehaqqIQMLQRAgatsesrpqtadqhsthRMRTETKA 257
Cdd:cd15186   154 EIWPVLRNVELN--------FLGFLLPLLIMSYCYFRI----------IQTLFSC-----------------KNHKKARA 198
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1938531436 258 AKTLCVIMGCFCFCWAPFFVT------NIVDPFIDYTVPEKVWTAFLW---LGYINSGLNPFLYAFLNKSFRR 321
Cdd:cd15186   199 IKLILLVVIVFFLFWTPYNVMifletlKLYDFFPSCDMKKDLRLALSVtetIAFSHCCLNPLIYAFAGEKFRR 271
7tmA_OR5M-like cd15412
olfactory receptor subfamily 5M and related proteins, member of the class A family of ...
20-134 5.98e-06

olfactory receptor subfamily 5M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5M and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320534  Cd Length: 279  Bit Score: 47.39  E-value: 5.98e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRkIKTNYFIVSLAFADLLVSVLVMPFGAIELVQD---IWFYGemfCLVR 96
Cdd:cd15412     1 PLLFVLFLVIYLITLLGNLGMILLIRLDSRLH-TPMYFFLSHLSFVDLCYSSNVTPKMLVNFLSEkktISFAG---CFTQ 76
                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1938531436  97 TSLDVLLTTASIFHLCCISLDRYYAIcCQPLVYRNKMT 134
Cdd:cd15412    77 CYFFIALVITEYYMLAVMAYDRYMAI-CNPLLYSVKMS 113
7tmA_OR5C1-like cd15945
olfactory receptor subfamily 5C1 and related proteins, member of the class A family of ...
19-155 6.09e-06

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5C1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320611  Cd Length: 292  Bit Score: 47.43  E-value: 6.09e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  19 KVVLLTFFAMVILMAILGNLLVMVAVCRDRQLRkIKTNYFIVSLAFADLLVSVLVMPFGAIELV---QDIWFYGemfCLV 95
Cdd:cd15945    13 KVTLFLVFLLVYLLTLVGNVGMIILIRMDSQLH-TPMYYFLSNLSFLDLCYSTAIGPKMLVDLLakrKSIPFYG---CAL 88
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  96 RTSLDVLLTTASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVIPMFISFL 155
Cdd:cd15945    89 QMFFFAAFADAECLLLAVMAYDRYVAI-CNPLLYTTAMSRRVCYLLLVGAYLSGMATSLV 147
7tmA_OR5AP2-like cd15943
olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of ...
19-148 7.57e-06

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AP2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320609 [Multi-domain]  Cd Length: 295  Bit Score: 47.36  E-value: 7.57e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  19 KVVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKiKTNYFIVSLAFADLLVSVLVMPFGAIELVQD---IWFYGemfCLV 95
Cdd:cd15943    14 QVILFAVFLVIYLITLVGNLGMIVLIRLDSRLHT-PMYFFLSHLSFLDLCYSSAITPKMLVNFLAEnktISFTG---CAA 89
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1938531436  96 RTSLDVLLTTASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVI 148
Cdd:cd15943    90 QMYFFVAFATTECFLLAVMAYDRYVAI-CNPLLYTVIMSPRVCIQLVAGSYLI 141
7tmA_OR5V1-like cd15231
olfactory receptor subfamily 5V1 and related proteins, member of the class A family of ...
20-147 8.00e-06

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5V1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320359 [Multi-domain]  Cd Length: 277  Bit Score: 46.87  E-value: 8.00e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKiKTNYFIVSLAFADLLVSVLVMPFGAIELV---QDIWFYGemfCLVR 96
Cdd:cd15231     1 LLLFLIFLIIYLVTLLGNLLIITLVLLDSHLHT-PMYFFLSNLSFLDICYTSVTVPKMLVNLLrerKTISYIG---CLAQ 76
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1938531436  97 TSLDVLLTTASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWV 147
Cdd:cd15231    77 LFFFVSFVGTECLLLAVMAYDRYVAI-CNPLHYAVIMSRKVCLQLAAASWL 126
7tmA_CCR6 cd15172
CC chemokine receptor type 6, member of the class A family of seven-transmembrane G ...
20-323 1.15e-05

CC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR6 is the only known receptor identified for the chemokine CCL20 (also known as macrophage inflammatory protein-3alpha, MIP-3alpha). CCR6 is expressed by all mature human B cells, effector memory T-cells, and dendritic cells found in the gut mucosal immune system. CCL20 contributes to recruitment of CCR6-expressing cells to Peyer's patches and isolated lymphoid follicles in the intestine, thereby promoting the assembly and maintenance of organized lymphoid structures. Also, CCL20 expression is highly inducible in response to inflammatory signals. Thus, CCL20 is involved in both inflammatory and homeostatic functions in the immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341330 [Multi-domain]  Cd Length: 281  Bit Score: 46.67  E-value: 1.15e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIkTNYFIVSLAFADLLVsVLVMPFGAIELvQDIWFYGEMFCLVRTSL 99
Cdd:cd15172     1 VFVPVIYSLICVVGLIGNSLVVITYAFYKRTKSM-TDVYLLNMAIADILF-VLTLPFWAVYE-AHQWIFGNFSCKLLRGI 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 100 DVLLTTASIFHLCCISLDRYYAIccqplVYRNKMTPLRIALMLGGcWVIPMFISFLPIMqgwnnIGIVDVIEKRKFNHNS 179
Cdd:cd15172    78 YAINFYSGMLLLACISVDRYIAI-----VQATKSFRLRSRTLAYS-KLICAAVWLLAIL-----ISLPTFIFSEVYDFGL 146
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 180 NSTF-CVF--------MVNKPYAITCSV-VAFYIPFLLMVLAYYRIYVTAkehaQQIQMLQRagatsesrpqtadqhsth 249
Cdd:cd15172   147 EEQYvCEPkypknstaIMWKLLVLSLQVsLGFFIPLLVMIFCYSFIIKTL----LQAQNSQR------------------ 204
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 250 rmrteTKAAKTLCVIMGCFCFCWAPFFVTNIV-------------DPFIDYTvpekvWTAFLWLGYINSGLNPFLYAFLN 316
Cdd:cd15172   205 -----HKAVRVVVAVVLVFLVCQVPYNIVLLIeainlgeqqscssEKAVAYA-----KTITECLAFFHCCLNPVLYAFIG 274

                  ....*..
gi 1938531436 317 KSFRRAF 323
Cdd:cd15172   275 VKFRNYF 281
7tmA_OR1330-like cd15946
olfactory receptor 1330 and related proteins, member of the class A family of ...
21-155 1.18e-05

olfactory receptor 1330 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes olfactory receptors 1330 from mouse, Olr859 from rat, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320612  Cd Length: 270  Bit Score: 46.32  E-value: 1.18e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  21 VLLTFFAMVILMAILGNLLVMVAVCRDRQLRkIKTNYFIVSLAFADLLVSVLVMPFGAIELV---QDIWFYGemfCLVRT 97
Cdd:cd15946     2 ILFAVFLLIYLSILLGNGLIITLICLDSRLH-TPMYFFLSVLSLLDMSYVTTTVPQMLVHLLshkKTISFTG---CVAQM 77
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1938531436  98 SLDVLLTTASIFHLCCISLDRYYAICcQPLVYRNKMTPLRIALMLGGCWVIPMFISFL 155
Cdd:cd15946    78 YIFLALGITECTLFSVMAYDRYVAIC-HPLRYKVIMSWGLCILMVAGSWVCGVFSSLL 134
7tmA_CCR3 cd15185
CC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
25-122 1.30e-05

CC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR3 is a highly promiscuous receptor that binds a variety of inflammatory CC-type chemokines, including CCL11 (eotaxin-1), CCL3L1, CCL5 (regulated on activation, normal T cell expressed and secreted; RANTES), CCL7 (monocyte-specific chemokine 3 or MCP-3), CCL8 (MCP-2), CCL11, CCL13 (MCP-4), CCL15, CCL24 (eotaxin-2), CCL26 (eotaxin-3), and CCL28. Among these, the eosinophil chemotactic chemokines (CCL11, CCL24, and CCL26) are the most potent and specific ligands. In addition to eosinophil, CCR3 is expressed on cells involved in allergic responses, such as basophils, Th2 lymphocytes, and mast cells. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341339 [Multi-domain]  Cd Length: 278  Bit Score: 46.36  E-value: 1.30e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  25 FFAMVILMAILGNLLVMVAVCRDRQLRkIKTNYFIVSLAFADLLVsVLVMPFGAIELVQDIWFYGEMFCLVRTSLDVLLT 104
Cdd:cd15185     6 LYSLVFIVGLLGNVVVVVILIKYRRLR-IMTNIYLLNLAISDLLF-LFTLPFWIHYVRWNNWVFGHGMCKLLSGFYYLGL 83
                          90
                  ....*....|....*...
gi 1938531436 105 TASIFHLCCISLDRYYAI 122
Cdd:cd15185    84 YSEIFFIILLTIDRYLAI 101
7tmA_EBI2 cd15159
Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G ...
20-122 1.47e-05

Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Epstein-Barr virus-induced G-protein coupled receptor 2 (EBI2), also called GPR183, is activated by 7alpha, 25-dihydroxyxcholesterol (7alpha, 25-OHC), an oxysterol. EBI2 was originally identified as one of major genes induced in the Burkitt's lymphoma cell line BL41by EBV infection. EBI2 is involved in regulating B cell migration and responses, and is also implicated in human diseases such as type I diabetes, multiple sclerosis, and cancers.


Pssm-ID: 320287 [Multi-domain]  Cd Length: 286  Bit Score: 46.19  E-value: 1.47e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQlrKIK-TNYFIVSLAFADLLVSvLVMPFGAIELVQDI-WFYGEMFCLVRT 97
Cdd:cd15159     1 VLLPLFYSLILVFGLLGNTLALHVICQKRK--KINsTTLYLINLAVSDILFT-LALPGRIAYYALGFdWPFGDWLCRLTA 77
                          90       100
                  ....*....|....*....|....*
gi 1938531436  98 SLDVLLTTASIFHLCCISLDRYYAI 122
Cdd:cd15159    78 LLFYINTYAGVNFMTCLSVDRYIAV 102
7tmA_GPR176 cd15006
orphan G protein-coupled receptor 176, member of the rhodopsin-like class A GPCR family; ...
28-321 1.52e-05

orphan G protein-coupled receptor 176, member of the rhodopsin-like class A GPCR family; GPR176 is a putative G protein-coupled receptor that belongs to the class A GPCR superfamily; no endogenous ligand for GPR176 has yet been identified. The class A rhodopsin-like GPCRs represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320135 [Multi-domain]  Cd Length: 289  Bit Score: 46.40  E-value: 1.52e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  28 MVILMAILGNLLVMVAVCRDRQLRKIkTNYFIVSLAFADLLVSVLVMPFGAIELVQD---IWFYGEMFCLVRTSLDVLLT 104
Cdd:cd15006     8 VIFVGSLLGNFMVLWSTCRTSVFKSV-TNRFIKNLACSGICASLVCVPFDIVLSASPhccWWIYTLLFCKVIKFLHKVFC 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 105 TASIFHLCCISLDRYYAIcCQPLvyRNKMTPLRIALMLGGCWVIPMFISfLPIMQGWNnigIVDVIEKRKFNHNSNSTFC 184
Cdd:cd15006    87 SVTVLSFAAIALDRYYSV-LYPL--ERKISDAKSRDLVIYIWAHAVVAS-VPVFAVTN---VTDIYAMSTCTESWGYSLG 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 185 VFMVNKPYAITCSVVAFYIPFLLMVLayYRIYVTAKEHAQQIQMLQRAGATSESRPQTADQhsthrmrtETKAAKTLCVI 264
Cdd:cd15006   160 HLVYVIIYNITTVILPVAVVFLFMIL--IRRALSASQKKKVIIAALRTPQNTISIPYVSQR--------EAELHAMLLSM 229
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1938531436 265 MGCFCFCWAPFFVTNIVDPFIDYT-VPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRR 321
Cdd:cd15006   230 VLVFILCSVPYATLVIYRTILNISdISVFLLLTAIWLPKVSLLANPLLFLTVNKSVRK 287
7tmA_LPAR1_Edg2 cd15344
lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial ...
29-323 1.94e-05

lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 341348 [Multi-domain]  Cd Length: 273  Bit Score: 45.79  E-value: 1.94e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  29 VILMAILGNLLVMVAVCRDRQLRkIKTNYFIVSLAFADLLVSVLVMPF------GAIELVQDIWfygemfcLVRTSLDVL 102
Cdd:cd15344    10 VCIFIMLANLLVMVAIYVNRRFH-FPIYYLMANLAAADFFAGLAYFYLmfntgpNTRRLTVSTW-------LLRQGLIDT 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 103 LTTASIFHLCCISLDRYYAICCQPLvyRNKMTPLRIALMLGGCWVIPMFISFLPIMqGWNNIGIVDviekrkfnhnsNST 182
Cdd:cd15344    82 SLTASVANLLAIAIERHITVFRMQL--HTRMSNRRVVVVIVVIWTMAIVMGAIPSV-GWNCICDIE-----------NCS 147
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 183 FCVFMVNKPYAITCSVVAFyIPFLLMVLAYYRIYVTAKEHaqqiqmlqragatsESRPQTADQHSTHRMRTETKAAKTLC 262
Cdd:cd15344   148 NMAPLYSDSYLVFWAIFNL-VTFVVMVVLYAHIFGYVRQR--------------TMRMSRHSSGPRRNRDTMMSLLKTVV 212
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1938531436 263 VIMGCFCFCWAPFFVTNIVD---PFIDYTVPEKVwtaFLWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15344   213 IVLGAFIICWTPGLVLLLLDvccPQCDVLAYEKF---FLLLAEFNSAMNPIIYSYRDKEMSATF 273
7tmA_OR4A-like cd15939
olfactory receptor 4A and related proteins, member of the class A family of ...
20-147 2.23e-05

olfactory receptor 4A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4A, 4C, 4P, 4S, 4X and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320605 [Multi-domain]  Cd Length: 267  Bit Score: 45.67  E-value: 2.23e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKiKTNYFIVSLAFADLLVSVLVMPFGAIELVQD---IWFYGemfCLVR 96
Cdd:cd15939     1 KICFVVFLLIYLATVLGNLLIVVTIKASQTLGS-PMYFFLSYLSFIDICYSSTTAPKLIVDLLSErktISFNG---CMTQ 76
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1938531436  97 TSLDVLLTTASIFHLCCISLDRYYAICcQPLVYRNKMTPLRIALMLGGCWV 147
Cdd:cd15939    77 LFAEHFFGGAEIFLLTVMAYDRYVAIC-KPLHYTTIMNRRVCGLLVGVAWV 126
PHA02638 PHA02638
CC chemokine receptor-like protein; Provisional
25-327 2.91e-05

CC chemokine receptor-like protein; Provisional


Pssm-ID: 165021 [Multi-domain]  Cd Length: 417  Bit Score: 45.77  E-value: 2.91e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  25 FFAMVILMAILGN-LLVMVAVCRdrqlrKIKT--NYFIVSLAFADLLVsVLVMPFgAIELVQDIWFYGEMFCLVRTSLDV 101
Cdd:PHA02638  104 FYIIIFILGLFGNaAIIMILFCK-----KIKTitDIYIFNLAISDLIF-VIDFPF-IIYNEFDQWIFGDFMCKVISASYY 176
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 102 LLTTASIFHLCCISLDRYYAICcQPLVYRnKMTPLRIALMLG-GCWVIPMFISfLPIMQGWNNIGIVdvIEKRKFNHN-S 179
Cdd:PHA02638  177 IGFFSNMFLITLMSIDRYFAIL-YPISFQ-KYRTFNIGIILCiISWILSLIIT-SPAYFIFEASNII--FSAQDSNETiS 251
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 180 NSTFCVFMVNKPYAIT---------CSVVAFYIPFLLMVLAYYRIYVTAKEhaqqiqmLQRAgatsesrpqtadqhsthr 250
Cdd:PHA02638  252 NYQCTLIEDNEKNNISflgrilqfeINILGMFIPIIIFAFCYIKIILKLKQ-------LKKS------------------ 306
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 251 mrTETKAAKTLCVIMGCFCFCWAPFFVTNIVDPFIDY----TVPEKVWTAFLWLGY----------INSGLNPFLYAFLN 316
Cdd:PHA02638  307 --KKTKSIIIVSIIIICSLICWIPLNIVILFATMYSFkgfnSIISEHICGFIKLGYammlaeaislTHCCINPLIYTLIG 384
                         330
                  ....*....|.
gi 1938531436 317 KSFRRAFLIIL 327
Cdd:PHA02638  385 ENFRMHLLMIF 395
7tmA_GPR34-like cd15920
P2Y-like receptor and similar proteins, member of the class A family of seven-transmembrane G ...
20-322 3.25e-05

P2Y-like receptor and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR34 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. GPR34 is shown to couple to G(i/o) protein and is highly expressed in microglia. Recently, lysophosphatidylserine has been identified as a ligand for GPR34. This group belongs to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320586 [Multi-domain]  Cd Length: 278  Bit Score: 45.17  E-value: 3.25e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQlRKIKTNYFIVSLAFADLLVsVLVMPFgaiELVQDIWFYGEMFCLVRTSL 99
Cdd:cd15920     1 VTLPVMYSIICIVGLLSNTLALWVFFLRQQ-RETSISVYMRNLALADLLL-VLCLPF---RVAYQNTAGPLSFCKIVGAF 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 100 DVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMlGGCWVIpMFISFLPIMQGWNNIGIVDviekRKFNHNS 179
Cdd:cd15920    76 FYLNMYASILFLSLISLDRYLKIIKPLQQFKIHTVPWSSAAS-GGVWLL-LLACMIPFLFESRNEGPCD----NKCFHFR 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 180 NSTFCVFMVNkpyaiTCSVVAFYIPFLLMVLAYYRIYVTAKEhaqqiqmlqragaTSESRPQTADQhsthrmRTETKAAK 259
Cdd:cd15920   150 SKGLTAGGIN-----LTAVVIFYILSLLFLYFYAKISHKLYK-------------VSLGNAQQQIK------KASKRAII 205
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1938531436 260 TLCVIMGCFCFCWAPFFVTNIvdPFI------DYTVPEKVW-----TAFLWLGYINSGLNPFLYAFLNKSFRRA 322
Cdd:cd15920   206 KTFIVLAIFIVCFVPYHIVRV--PYVlaqidvISSLPWKQTlhianELVLCLSALNSCLDPIIYFFLSSSFRRA 277
7tmA_PAR4 cd15372
protease-activated receptor 4, member of the class A family of seven-transmembrane G ...
49-212 3.27e-05

protease-activated receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320494 [Multi-domain]  Cd Length: 274  Bit Score: 45.12  E-value: 3.27e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  49 QLRKIKTNYFIVSLAFADLLVsVLVMPFG-AIELVQDIWFYGEMFCLVRTSLDVLLTTASIFHLCCISLDRYYAIcCQPL 127
Cdd:cd15372    28 QVKRLPSTIFLINLAVADLLL-ILVLPFKiSYHFLGNNWPFGEGLCRVVTAFFYGNMYCSVLLLMCISLDRYLAV-VHPF 105
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 128 VYRNKMTPLRIALMLGGCWVIPMfISFLPImqgwnnigivdVIEKRKFN-HNSNSTFC--VFMVNK------PYAITCSV 198
Cdd:cd15372   106 FARTLRSRRFALCMCTAIWLIAA-ALTLPL-----------TLQRQSYPlERLNITLChdVLPLDEqdtylfYYFACLAV 173
                         170
                  ....*....|....
gi 1938531436 199 VAFYIPFLLMVLAY 212
Cdd:cd15372   174 LGFLLPLVVILFCY 187
7tmA_OR5AK3-like cd15408
olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of ...
19-148 3.42e-05

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AK3, 5AU1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320530  Cd Length: 287  Bit Score: 45.00  E-value: 3.42e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  19 KVVLLTFFAMVILMAILGNLLVMVAVCRDRQLRkIKTNYFIVSLAFADLLVSVLVMPFGAIELVQD---IWFYGemfCLV 95
Cdd:cd15408    13 QVLLFVVFLLIYVITLVGNLGMILLIRLDSRLH-TPMYFFLSHLSFLDICYSSTITPKTLLNLLAErkvISFTG---CLT 88
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1938531436  96 RTSLDVLLTTASIFHLCCISLDRYYAICcQPLVYRNKMTPLRIALMLGGCWVI 148
Cdd:cd15408    89 QLYFYAVFATTECYLLAAMAYDRYVAIC-NPLLYTVIMSQRVCVSLVAGSYLA 140
7tmA_PAR2 cd15370
protease-activated receptor 2, member of the class A family of seven-transmembrane G ...
48-320 3.43e-05

protease-activated receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341349 [Multi-domain]  Cd Length: 280  Bit Score: 45.17  E-value: 3.43e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  48 RQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSLDVLLTTASIFHLCCISLDRYYAICcQPL 127
Cdd:cd15370    28 RTKKKHPAVIYMANLALADLLFVIWFPLKIAYHINGNNWIYGEALCKVLIGFFYGNMYCSILFMTCLSVQRYWVIV-NPM 106
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 128 VYRNKMTplRIALMLGGCWVIPMFISFLPIMQGWNNIGIVDVIEKRKFNHNSNSTFCVFMVNkpYAITCSVVAFYIPFLL 207
Cdd:cd15370   107 SHSRKKA--NIAIGISLAIWLLILLVTIPLYLVKQTVFIPALDITTCHDVLPEQLLVGDMFN--YFLSLAIGVFLFPAFL 182
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 208 MVLAYyriyvtakehaqqIQMLqRAGATSESRPQTAdqhsthrmRTETKAAKTLCVIMGCFCFCWAPFFVTNIVDPFIDY 287
Cdd:cd15370   183 TAVAY-------------VLMI-RALKSSINDESIE--------KKRKRAIKLIVTVLVMYLICFTPSNLLLVVHYFLLK 240
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1938531436 288 TVPEKVWTAF----LWLGYINSGLNPFLYAFLNKSFR 320
Cdd:cd15370   241 NQGQSSVYAFyitaLCLSTLNSCIDPFVYYFVSHDFR 277
7tmA_OR1E-like cd15236
olfactory receptor subfamily 1E and related proteins, member of the class A family of ...
21-155 3.65e-05

olfactory receptor subfamily 1E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1E, 1J, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320364 [Multi-domain]  Cd Length: 277  Bit Score: 45.14  E-value: 3.65e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  21 VLLTFFAMVILMAILGNLLVMVAVCRDRQLRKiKTNYFIVSLAFADLLVSVLVMPFGAIEL---VQDIWFYGemfCLVRT 97
Cdd:cd15236     2 VFFALFLAMYLTTVLGNLLIILLIRLDSHLHT-PMYFFLSHLAFTDVSFSSVTVPKMLMNMqtqDQSIPYAG---CISQM 77
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1938531436  98 SLDVLLTTASIFHLCCISLDRYYAICcQPLVYRNKMTPLRIALMLGGCWVIPMFISFL 155
Cdd:cd15236    78 YFFIFFGCLDSFLLAVMAYDRYVAIC-HPLHYTAIMRPELCVLLVAGSWVLTCFHALL 134
7tmA_OR6B-like cd15224
olfactory receptor subfamily 6B and related proteins, member of the class A family of ...
20-157 3.92e-05

olfactory receptor subfamily 6B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6B, 6A, 6Y, 6P, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320352  Cd Length: 270  Bit Score: 44.97  E-value: 3.92e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKiKTNYFIVSLAFADLL-VSVLV--MPFGAIELVQDIWFYGemfCLVR 96
Cdd:cd15224     1 LLLFLLFLIAYVLTLLENLLIILTIWLNSQLHK-PMYFFLSNLSFLEIWyISVTVpkLLAGFLSQNKSISFVG---CMTQ 76
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1938531436  97 TSLDVLLTTASIFHLCCISLDRYYAICcQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPI 157
Cdd:cd15224    77 LYFFLSLACTECVLLAVMAYDRYVAIC-HPLRYPVIMTHQLCVQLAAGSWLSGFLISMIKV 136
7tmA_CCR8 cd15187
CC chemokine receptor type 8, member of the class A family of seven-transmembrane G ...
22-321 4.00e-05

CC chemokine receptor type 8, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR8, the receptor for the CC chemokines CCL1 and CC16, is highly expressed on allergen-specific T-helper type 2 cells, and is implicated in the pathogenesis of human asthma. CCL1- and CCR8-expressing CD4+ effector T lymphocytes are shown to have a critical role in lung mucosal inflammatory responses. CCR8 is also a functional receptor for CCL16, a liver-expressed CC chemokine that involved in attracting lymphocytes, dendritic cells, and monocytes. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320315 [Multi-domain]  Cd Length: 276  Bit Score: 44.79  E-value: 4.00e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  22 LLTFFAMVILMAILGNLLVMVAVCRDRQLRKIkTNYFIVSLAFADLLVsVLVMPFGAIELVqDIWFYGEMFCLVRTSLDV 101
Cdd:cd15187     3 LPVLYCLLFVFGLLGNSLVIWVLVACKKLRSM-TDVYLLNLAASDLLF-VFSLPFQAYYLL-DQWVFGNAMCKIVSGAYY 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 102 LLTTASIFHLCCISLDRYYAICCQplVYRNKMTPLRIALMLGGCWVIPMFISFLPIMQGWNNIGIVDVIEKRKFNHNSNS 181
Cdd:cd15187    80 IGFYSSMFFITLMSIDRYLAIVHA--VYALKVRTASHGTILSLALWLVAILASVPLLVFYQVASEDGRLQCIPFYPGQGN 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 182 TFCVFMVNKpyaitCSVVAFYIPFLLMVLAYYRIyvtakehaqqIQMLQRAgatsesrpqtadqhsthRMRTETKAAKTL 261
Cdd:cd15187   158 SWKVFTNFE-----VNILGLLIPFSILIFCYHNI----------LRNLRRC-----------------HNQNKTKAIKLV 205
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1938531436 262 CVIMGCFCFCWAPFFVTNIVDPF-----IDYTVPEKVWTAFLWL----GYINSGLNPFLYAFLNKSFRR 321
Cdd:cd15187   206 FIVVIVFFLFWTPFNVVLFLDSLhslhiIDGCQNSQRLTLALHLtetiSFTHCCLNPVIYAFVGEKFKK 274
7tmA_OXER1 cd15200
oxoeicosanoid receptor 1, member of the class A family of seven-transmembrane G ...
20-323 4.01e-05

oxoeicosanoid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; OXER1, also called GPR170, is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid. OXER1 is a member of the class A family of seven-transmembrane G-protein coupled receptors and appears to be coupled to the G(i/o) protein. The receptor is expressed in various tissues except brain. Phylogenetic analysis showed that GPR31 and OXER1 are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). OXER1, like GPR31, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike GPR31, does cause increase in the cytosolic calcium level.


Pssm-ID: 320328 [Multi-domain]  Cd Length: 276  Bit Score: 44.76  E-value: 4.01e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIKTnYFIVSLAFADLLVsVLVMPFGA-IELVQDIWFYGEMFCLVRTS 98
Cdd:cd15200     1 AFLAPVLGIEFVLGLVGNGIALFIFCFHRRPWKSNT-MYLLSLVVADFFL-IINLPFRIdYYLRNEVWRFGATACQVNLF 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  99 LDVLLTTASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMQGWNNIGivdvIEKRKFNHN 178
Cdd:cd15200    79 MLSMNRTASIVFLTAIALNRYLKV-VHPHHQLSKASVGCAAKVAAGLWILILLLNIHLLLLDHVQSN----STCLSYDHG 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 179 SNSTfcvfmVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTakehaqqiqmLQRAGATSESRPQtadqhsthrmrtetKAA 258
Cdd:cd15200   154 TDPS-----ASDRWHRILFFLEFFLPLGIILFCIFSIILT----------LKQRKLAKQAGPQ--------------RAV 204
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1938531436 259 KTLCVIMGCFCFCWAPFFVTNI-------VDPFIDYTVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15200   205 KVLAVIVLVYTVCFLPSILFALaslvafkVSQCRSLDLCTQLFHGSLAFTYLNSALDPVLYCFSSPSFLNQS 276
7tmA_GPR55-like cd15165
G protein-coupled receptor 55 and similar proteins, member of the class A family of ...
58-231 4.24e-05

G protein-coupled receptor 55 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR55 shares closest homology with GPR35, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Lysophosphatidylinositol (LPI) is currently considered as the endogenous ligand for GPR55, although the receptor was initially de-orphanized as a cannabinoid receptor and binds many cannabinoid ligands.


Pssm-ID: 320293 [Multi-domain]  Cd Length: 277  Bit Score: 44.63  E-value: 4.24e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  58 FIVSLAFADLLVsVLVMPFgAIELVQDIWFYGEMFCLVRTSLDVLLTTASIFHLCCISLDRYYAIcCQPLVYRNKMTPLR 137
Cdd:cd15165    38 YMINLALNDLLL-LLSLPF-KMHSSKKQWPLGRTLCSFLESLYFVNMYGSILIIVCISVDRYIAI-RHPFLAKRLRSPRK 114
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 138 IALMlggCWVIPMFISflpimqgwnnIGIVDVIEKRKFNHNSNSTFCVF---MVNKPYAITCSVVAFYIPFLLMVLAYYR 214
Cdd:cd15165   115 AAIV---CLTIWVFVW----------AGSIPIYSFHDKPTNNTRCFHGFsnkTWSKKVIVVVEEFGFLIPMAVMVFCSVQ 181
                         170
                  ....*....|....*..
gi 1938531436 215 IYVTAKEHAQQIQMLQR 231
Cdd:cd15165   182 IIRTLLDMRRPEQPKVK 198
7tmA_GPR33 cd15120
orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled ...
20-221 4.39e-05

orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor GPR33, an orphan member of the chemokine-like receptor family, was originally identified as a pseudogene in humans as well as in several apes and rodent species. Although the intact GPR33 allele is still present in a small fraction of the human population, the human GPR33 contains a premature stop codon. The amino acid sequence of GPR33 shares a high degree of sequence identity with the members of the chemokine and chemoattractant receptors that control leukocyte chemotaxis. The human GPR33 is expressed in spleen, lung, heart, kidney, pancreas, thymus, gonads, and leukocytes.


Pssm-ID: 320248 [Multi-domain]  Cd Length: 282  Bit Score: 44.77  E-value: 4.39e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMvAVCRDRQLRKIKTNYFIvSLAFADLLvSVLVMPFGAIELVQDI-WFYGEMFCLVRTS 98
Cdd:cd15120     1 VLIAVALFVTFLVGLVVNGLYL-WVLGFKMRRTVNTLWFL-HLILSNLI-FTLILPFMAVHVLMDNhWAFGTVLCKVLNS 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  99 LDVLLTTASIFHLCCISLDRYYaICCQPLVYRNKMTPLRIALMLGGCWVIPMFIS--FLPIMQGWNNIGIVDVIEKRKFN 176
Cdd:cd15120    78 TLSVGMFTSVFLLTAISLDRYL-LTLHPVWSRQHRTNRWASAIVLGVWISAILLSipYLAFRETRLDEKGKTICQNNYAL 156
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1938531436 177 HNSNSTFCVFMVNKPYAITCSVV----AFYIPFLLMVLAYYRIYVTAKE 221
Cdd:cd15120   157 STNWESAEVQASRQWIHVAMFVFrfllGFLLPFLIITFCYVRMALKMKE 205
7tmA_OR4Q2-like cd15938
olfactory receptor 4Q2 and related proteins, member of the class A family of ...
20-146 4.68e-05

olfactory receptor 4Q2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320604 [Multi-domain]  Cd Length: 265  Bit Score: 44.48  E-value: 4.68e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRkiKTNYFIV-SLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTS 98
Cdd:cd15938     1 ALLFALFLLAYTMVLVGNLLIMVTVRSDPKLS--SPMYFLLgNLSFLDLCYSTVTCPKMLVDFLSQRKAISYEACIAQLF 78
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1938531436  99 LDVLLTTASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCW 146
Cdd:cd15938    79 FLHFVGAAEMFLLTVMAYDRYVAI-CKPLHYTTIMSRRLCWVLVAASW 125
7tmA_PD2R2_CRTH2 cd15118
prostaglandin D2 receptor, member of the class A family of seven-transmembrane G ...
20-314 5.27e-05

prostaglandin D2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. PD2R2 is involved in mediating chemotaxis of Th2 cells, eosinophils, and basophils generated during allergic inflammatory processes. CRTH2 (PD2R2), but not DP receptor, undergoes agonist-induced internalization which is one of key processes that regulates the signaling of the GPCR.


Pssm-ID: 320246 [Multi-domain]  Cd Length: 284  Bit Score: 44.41  E-value: 5.27e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAV-CRdrqLRKIKTNYFIVSLAFADLLVSvLVMPFGAIEL-VQDIWFYGEMFCLVRT 97
Cdd:cd15118     1 VATICLHGIVSTLGIVENLLILWVVgFR---LRRTVISIWILNLALSDLLAT-LSLPFFTYYLaSGHTWELGTTFCRIHS 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  98 SLDVLLTTASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMqgwnnigIVDVIEK---RK 174
Cdd:cd15118    77 SIFFLNMFVSGFLLAAISLDRCLLV-VKPVWAQNHRNVAAAKKICGVIWAMALINTIPYFV-------FRDVIERkdgRK 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 175 FNH----------NSNSTFCVFMvNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEhaqqiqmlqragatsesrpqtad 244
Cdd:cd15118   149 LCYynfalfspspDNNHPICKQR-QEGLAISKLLLAFLIPLVIIAVSYAVVSLIIRH----------------------- 204
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1938531436 245 qhstHRMRTETKAAKTLCVIMGCFCFCWAPFFVTNIVDPFIDYT--VPEKVWTAFLW---LGYINSGLNPFLYAF 314
Cdd:cd15118   205 ----RCRRRPGRFVRLVVSVVVSFALCWAPYHIFSIIEVMAHNQhsLRPLVIQGLPFattLAFLNSVLNPVLYVF 275
7tmA_OR5G-like cd15414
olfactory receptor subfamily 5G and related proteins, member of the class A family of ...
20-155 5.80e-05

olfactory receptor subfamily 5G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320536 [Multi-domain]  Cd Length: 285  Bit Score: 44.34  E-value: 5.80e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRkIKTNYFIVSLAFADLLVSVLVMPFGAIELV---QDIWFYGemfCLVR 96
Cdd:cd15414     1 IPLFLLFLLVYLITLLGNLGMIILIQVDSRLH-TPMYFFLSHLSFVDLCYSSVVTPKMLSDFFvekKAISFLG---CAAQ 76
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  97 TSLDVLLTTASIFHLCCISLDRYYAIcCQPLVYRNKMTP-LRIALMLGgcwviPMFISFL 155
Cdd:cd15414    77 MWFFGLFVAAECFLLASMAYDRYVAI-CNPLLYTVIMSQrVCVQLVVG-----PYVVGLL 130
7tmA_GPR35-like cd15164
G protein-coupled receptor 35 and similar proteins, member of the class A family of ...
23-323 5.87e-05

G protein-coupled receptor 35 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR35 shares closest homology with GPR55, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A number of studies have suggested that GPR35 may play important physiological roles in hypertension, atherosclerosis, nociception, asthma, glucose homeostasis and diabetes, and inflammatory bowel disease. GPR35 is thought to be responsible for brachydactyly mental retardation syndrome, which is associated with a deletion comprising chromosome 2q37 in human, and is also implicated as a potential oncogene in stomach cancer. Several endogenous ligands for GPR35 have been identified including kynurenic acid, 2-oleoyl lysophosphatidic acid, and zaprinast. GPR35 couples to G(13) and G(i/o) proteins.


Pssm-ID: 320292 [Multi-domain]  Cd Length: 272  Bit Score: 44.17  E-value: 5.87e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  23 LTFFAMVILMAILGNLLVMVAV----CRDRqlRKIKTNYFIVSLAFADLLVsVLVMPFGAIELVQDIWfyGEMFCLVRTS 98
Cdd:cd15164     1 LIQLIIYIPILFFGLLFNVLALwvfcCKMK--KWTETRVYMINLAVADCCL-LFSLPFVLYFLKHSWP--DDELCLVLQS 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  99 LDVLLTTASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVIpmFISFLPIMQGWNnigivdviekrkfnhN 178
Cdd:cd15164    76 IYFINRYMSIYIITAIAVDRYIAI-KYPLKAKSLRSPRKAALTCGLLWVL--VIISVSLRLAWE---------------E 137
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 179 SNSTFCVFMVNK---PYAITCSVVAFYIPFLLMVLAYYRIyvtakehaqqIQMLQRAGATsesrpqtadqhSTHRMRTET 255
Cdd:cd15164   138 QEENFCFGKTSTrpsKRTLIFSLLGFFIPLIILSFCSIQV----------IRSLKKKKKT-----------NPHEEKLIQ 196
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1938531436 256 KAAKTLCVIMGCFCFCWAPFFVTNIVDPFIDYTVPE----KVWTAFL----WLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15164   197 KAIYIVSANLIVFIVCFLPLHIGLLVRFVMESNKAScsliQNIRNFIyvasCLANANCCLDAICYYFVAKEFQEAS 272
7tmA_OR11A-like cd15911
olfactory receptor subfamily 11A and related proteins, member of the class A family of ...
20-218 6.00e-05

olfactory receptor subfamily 11A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11A and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320577  Cd Length: 270  Bit Score: 44.40  E-value: 6.00e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKiKTNYFIVSLAFADLLVSVLVMPFGAIELVQD---IWFYGemfCLVR 96
Cdd:cd15911     1 ILLFLLFLVIYIVTMAGNILIIVLVVADRHLHT-PMYFFLGNLSCLEICYTSTILPRMLASLLTGdrtISVSG---CIVQ 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  97 TSLDVLLTTASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWV---IPMFISFLPIMQ----GWNNIgivdv 169
Cdd:cd15911    77 FYFFGSLAATECYLLAVMSYDRYLAI-CKPLHYASLMNGRLCLQLAAGSWIsgfLASTITVILMSQltfcGPNEI----- 150
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1938531436 170 iekrkfNHnsnsTFCVF------------MVNKPYAITCSVVAFyIPFLLMVLAYYRIYVT 218
Cdd:cd15911   151 ------DH----FFCDFapllklscsdtsLVELVTFILSSIVTL-PPFLLTLTSYICIIST 200
7tmA_OR2-like cd15237
olfactory receptor family 2 and related proteins, member of the class A family of ...
21-215 6.53e-05

olfactory receptor family 2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 2 and 13, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320365 [Multi-domain]  Cd Length: 270  Bit Score: 44.19  E-value: 6.53e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  21 VLLTFFAMVILMAILGNLLVMVAVCRDRQLRKikTNYFIVS-LAFADLLVSVLVMPFGAIELV---QDIWFYGemfCLVR 96
Cdd:cd15237     2 LLFILFLLIYLLTLLGNGLIILLIWLDSRLHT--PMYFFLSnLSLLDICYTTSTVPQMLVHLLsehKTISFVG---CAAQ 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  97 TSLDVLLTTASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVIPMFISF--------LPiMQGWNNIgivd 168
Cdd:cd15237    77 MFFFLALGVTECVLLAVMAYDRYVAI-CNPLRYSVIMSRRVCVRLAATSWASGFLNSLvltsltlrLP-FCGPNHI---- 150
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1938531436 169 viekrkfnhnsNSTFC----VF-------MVNKPYAITCSVVAFYIPFLLMVLAYYRI 215
Cdd:cd15237   151 -----------NHFFCeapaVLklacadtSLNEAVIFVTSVLVLLIPFSLILASYIRI 197
7tmA_ET-CR cd15977
endothelin C receptor, member of the class A family of seven-transmembrane G protein-coupled ...
28-153 6.98e-05

endothelin C receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain. The ET-C receptor is specific for endothelin-3 on frog dermal melanophores; its activation causes dispersion of pigment granules.


Pssm-ID: 320643 [Multi-domain]  Cd Length: 296  Bit Score: 44.13  E-value: 6.98e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  28 MVILMAILGNLLVMVAVCRDRQLRKiKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSLDVLLTTAS 107
Cdd:cd15977     9 VIFLVGIIGNSTLLRIIYKNKCMRN-GPNVLIASLALGDLLYILIAIPINVIKLIAEDWPFGVHVCKLYPFIQKASVGIT 87
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1938531436 108 IFHLCCISLDRYYAICCQPLVyRNKMTPLRIALMLGGCWVIPMFIS 153
Cdd:cd15977    88 VLSLCALSIDRYRAVASWSRI-RGIGIPVWKAVEVTLIWAVAIIVA 132
7tmA_GPR65_TDAG8 cd15365
proton-sensing G protein-coupled receptor 65, member of the class A family of ...
25-320 7.38e-05

proton-sensing G protein-coupled receptor 65, member of the class A family of seven-transmembrane G protein-coupled receptors; The T cell death associated gene-8 receptor (TDAG8, also known as GPR65) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. Activation of TDAG8 by extracellular acidosis increases the cAMP production, stimulates Rho, and induces stress fiber formation. TDAG8 has also been shown to regulate the extracellular acidosis-induced inhibition of pro-inflammatory cytokine production in peritoneal macrophages.


Pssm-ID: 320487 [Multi-domain]  Cd Length: 277  Bit Score: 44.00  E-value: 7.38e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  25 FFAMVILMAILGNLLVMVAVCRDRQlRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSLDVLLT 104
Cdd:cd15365     6 VYIFVIVISIPSNCISLYVSCLQIR-KKNELGVYLFNLSLSDLLYIVILPLWIDYLWNGDNWTLSGFVCIFSAFLLYTNF 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 105 TASIFHLCCISLDRYYAIcCQPLVYRNKMTpLRIALMLG-GCWVIPMFISFLPIMQgwnnigivdvieKRKFNHNSNSTF 183
Cdd:cd15365    85 YTSTALLTCIALDRYLAV-VHPLKFMHLRT-IRTALSVSvAIWLLEICFNAVILTW------------EDSFHESSSHTL 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 184 CV-FMVNKPYAITCSVVAF----YIPFLLMVLAYYRIYVTAKehaqqiqmlqragatseSRPQTADQHsthrmrtETKAA 258
Cdd:cd15365   151 CYdKFPLEDWQARLNLFRIclgyLLPLLIILFCYWKIYQAVR-----------------SNQATEDQE-------KKKIF 206
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1938531436 259 KTLCVIMGCFCFCWAPFFVTNIVDPFIDYTVPEKV-WTAFLW-----LGYINSGLNPFLYAFLNKSFR 320
Cdd:cd15365   207 KLLLLITVTFVICFTPYHVVLLIRSIVEPCDCRNAkWLYTLYkitvaLTSLNCIADPFLYCFVTESGR 274
7tmA_OR10G-like cd15916
olfactory receptor subfamily 10G and related proteins, member of the class A family of ...
22-148 8.02e-05

olfactory receptor subfamily 10G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10G, 10S, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320582 [Multi-domain]  Cd Length: 276  Bit Score: 43.98  E-value: 8.02e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  22 LLTFFAMVILMAILGNLLVMVAVCRDRQLRKiKTNYFIVSLAFADLLVSVLVMPFGAIELVQD----IWFYGemfCLVRT 97
Cdd:cd15916     3 LFLIFLIIYLLTVLGNLLILLTVWVDSHLHR-PMYIFLGHLSFLDMWLSTVTVPKMLAGFLEPggkvISFGG---CVAQL 78
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1938531436  98 SLDVLLTTASIFHLCCISLDRYYAICcQPLVYRNKMTPLRIALMLGGCWVI 148
Cdd:cd15916    79 YFFHFLGSTECFLYTLMAYDRYLAIC-HPLHYPTIMTGRLCTRLATGTWVA 128
7tmA_OR5P-like cd15416
olfactory receptor subfamily 5P and related proteins, member of the class A family of ...
20-155 8.37e-05

olfactory receptor subfamily 5P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5P and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320538 [Multi-domain]  Cd Length: 279  Bit Score: 43.89  E-value: 8.37e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKikTNYFIVS-LAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTS 98
Cdd:cd15416     1 IILFVLFLVIYSVTLLGNLSIILLIRISSQLHT--PMYFFLShLAFSDICYSSSVTPKMLVNFLVEKTTISYPGCAAQLC 78
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1938531436  99 LDVLLTTASIFHLCCISLDRYYAIcCQPLVYRNKMTP-----LRIALMLGGCWVIPMFISFL 155
Cdd:cd15416    79 SAATFGTVECFLLAAMAYDRYVAI-CNPLLYSTIMSQkvcvlLVAASYLGGCLNALVFTTCV 139
7tmA_Encephalopsin cd15078
encephalopsins (opsin-3), member of the class A family of seven-transmembrane G ...
27-321 8.53e-05

encephalopsins (opsin-3), member of the class A family of seven-transmembrane G protein-coupled receptors; Encephalopsin, also called Opsin-3 or Panopsin, is a mammalian extra-retinal opsin that is highly localized in the brain. It is thought to play a role in encephalic photoreception. Encephalopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320206 [Multi-domain]  Cd Length: 279  Bit Score: 44.05  E-value: 8.53e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  27 AMVILMAILGNLLVMVAVCRDRQLRKiKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSLDVLLTTA 106
Cdd:cd15078     8 ATIGFLGVCNNLLVLILYYKFKRLRT-PTNLLLVNISLSDLLVSLLGVTFTFMSCVRGRWVFDVAGCVWDGFSNSLFGIV 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 107 SIFHLCCISLDRYYAIccqplVYRNKMTPLRIALMLGGCWVIPMFISFLPIMqGWN----NIGIVDVIEKRKFNHNSNST 182
Cdd:cd15078    87 SIMTLTVLAYERYIRV-----VHAKVVNFSWSWRAITYIWLYSLAWTGAPLL-GWNrytlEVHGLGCSFDWKSKDPNDTS 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 183 FCVFMVnkpyaitcsVVAFYIPFLLMVLAYYRIYVTakehaqqIQMLQRAGATSESRPQTAdqhsthrMRTETKAAKTLC 262
Cdd:cd15078   161 FVLLFF---------LGCLVVPLGIMAYCYGHILYE-------IRMLRSVEDLQTFQVIKI-------LKYEKKVAKMCL 217
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 263 VIMGCFCFCWAPFFVTNIVDPF-IDYTVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRR 321
Cdd:cd15078   218 LMISTFLICWMPYAVVSLLVTSgYSKLVTPTIAIIPSLFAKSSTAYNPVIYIFMIRKFRQ 277
7tmA_CysLTR cd15921
cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G ...
24-323 8.72e-05

cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320587 [Multi-domain]  Cd Length: 283  Bit Score: 44.03  E-value: 8.72e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  24 TFFAMVILMAILGNLLVmVAVCRDRQLRKIKTNYFIVSLAFADLLVsVLVMPFGAIELVQDI-WFYGEMFCLVRTSLDVL 102
Cdd:cd15921     5 TAYILIFILGLTGNSIS-VYVFLSQYRSQTPVSVLMVNLAISDLLL-VCTLPLRLTYYVLNShWPFGDIACRIILYVLYV 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 103 LTTASIFHLCCISLDRYYAICcQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMQGwnnigivdviekrKFNHNSNST 182
Cdd:cd15921    83 NMYSSIYFLTALSVFRYLALV-WPYLYLRVQTHSVAGIICGLIWILMGLASSPLLFAK-------------SKQHDEGST 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 183 FCVFMVN--KPYAITCS----VVAFYIPFLLMVLAYYRIYVTakehaqqiqMLQRAGATSESRPqtadqhsTHRmrtetK 256
Cdd:cd15921   149 RCLELAHdaVDKLLLINyvtlPVGFVVPFMTVIFCYIFIIKN---------LLKPSPALGRTRP-------SRR-----K 207
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1938531436 257 AAKTLCVIMGCFCFCWAPFFVTNIVDPFIDYTVPE---------KVWTAFLWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15921   208 ACALIIISLGIFLVCFLPYHIVRTIHLITERQIKEscgyilrvrKAAVITLCLAASNSCFDPLLYFFVGENFRSRL 283
7tmA_OR2A-like cd15420
olfactory receptor subfamily 2A and related proteins, member of the class A family of ...
20-323 9.59e-05

olfactory receptor subfamily 2A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320542 [Multi-domain]  Cd Length: 277  Bit Score: 43.86  E-value: 9.59e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKiKTNYFIVSLAFADLLVSVLVMPFGAIELV---QDIWFYGemfCLVR 96
Cdd:cd15420     1 LLLFGLFSLLYIFTLLGNGLILGLIWLDSRLHT-PMYFFLSHLAVVDICYASSTVPHMLGNLLkqrKTISFAG---CGTQ 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  97 TSLDVLLTTASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMQGWNnigiVDVIEKRKFN 176
Cdd:cd15420    77 MYLFLALAHTECVLLAVMSYDRYVAI-CHPLRYTVIMNWRVCTTLAATSWACGFLLALVHVVLLLR----LPFCGPNEVN 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 177 HnsnsTFCVFM-----------VNKPYAITCSVVAFYIPFLLMVLAYYRIYVTakehaqqIQMLQragaTSESRPQTADQ 245
Cdd:cd15420   152 H----FFCEILavlklacadtwINEILIFAGCVFILLGPFSLILISYLHILAA-------ILKIQ----SAEGRRKAFST 216
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 246 HSTHrmrtetkaaktLCVImgcfcfcwAPFFVTNIvdpfIDYTVPEKVWTA------FLWLGYINSGLNPFLYAFLNKSF 319
Cdd:cd15420   217 CSSH-----------LCVV--------GLFYGTAM----FMYMVPGSSNSAeqekilSLFYSLFNPMLNPLIYSLRNKQV 273

                  ....
gi 1938531436 320 RRAF 323
Cdd:cd15420   274 KGAL 277
7tmA_OR8D-like cd15406
olfactory receptor subfamily 8D and related proteins, member of the class A family of ...
22-148 1.09e-04

olfactory receptor subfamily 8D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8D and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320528 [Multi-domain]  Cd Length: 290  Bit Score: 43.51  E-value: 1.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  22 LLTFFAMVILMAILGNLLVMVAVCRDRQLrKIKTNYFIVSLAFADLLVSVLVMP--FGAIELVQDIWFYGEmfCLVRTSL 99
Cdd:cd15406    12 LFLLFLGIYVVTVVGNLGMILLITLSSQL-HTPMYYFLSNLSFIDLCYSSVITPkmLVNFVSEKNIISYPE--CMTQLFF 88
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1938531436 100 DVLLTTASIFHLCCISLDRYYAICCqPLVYRNKMTPLRIALMLGGCWVI 148
Cdd:cd15406    89 FCVFAIAECYMLTAMAYDRYVAICN-PLLYNVTMSPRVCSLLVAGVYIM 136
7tmA_ACKR3_CXCR7 cd14987
CXC chemokine receptor 7, member of the class A family of seven-transmembrane G ...
25-122 1.56e-04

CXC chemokine receptor 7, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR3, also known as CXCR7, is an atypical chemokine receptor for CXCL12 and CXCR11. Unlike the classical chemokine receptors, ACKR3 contains a DRYLSIT-sequence instead of the conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. Thus, ACKR3 does not activate classical GPCR signaling, instead induces beta-arrestin recruitment which is leading to ligand internalization and MAP-kinase activation. It is acting as a scavenger for CXCL12 and, to a lesser degree, for CXCL11. ACKR3 is highly expressed by blood vascular endothelial cells in brain, in numerous embryonic and neonatal tissues, in inflamed tissues and in a variety of cancers such as lymphomas, sarcomas, prostate and breast cancers, and gliomas. Five receptors have been identified for the ACKR family, including CC-Chemokine Receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, DARC, and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320118 [Multi-domain]  Cd Length: 282  Bit Score: 43.21  E-value: 1.56e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  25 FFAMVILMAILGNLLVmVAVCRDRQLRKIKTNYFIVSLAFADLLVsVLVMPFGAIELVQ-DIWFYGEMFCLVRTSLDVLL 103
Cdd:cd14987     6 FYIFIFVIGLLANSVV-VWVNLQAKRTGYETHLYILNLAIADLCV-VATLPVWVVSLVQhNQWPMGEFTCKITHLIFSIN 83
                          90
                  ....*....|....*....
gi 1938531436 104 TTASIFHLCCISLDRYYAI 122
Cdd:cd14987    84 LFGSIFFLTCMSVDRYLSV 102
7tmA_OR7-like cd15234
olfactory receptor family 7 and related proteins, member of the class A family of ...
21-155 1.58e-04

olfactory receptor family 7 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 7 and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320362 [Multi-domain]  Cd Length: 277  Bit Score: 42.95  E-value: 1.58e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  21 VLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIKtnYFIVS-LAFADLLVSVLVMPFGAIELV---QDIWFYGemfCLVR 96
Cdd:cd15234     2 LLFGLFLSMYLVTVLGNLLIILAVSSDSHLHTPM--YFFLSnLSFADICFSSTTVPKMLVNIQtqsKSISYTG---CLTQ 76
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1938531436  97 TSLDVLLTTASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVIPMFISFL 155
Cdd:cd15234    77 MCFFLLFGGLDNFLLAVMAYDRYVAI-CHPLHYTVIMNPCLCGLLVLLSLLISILDSLL 134
7tmA_OR4E-like cd15940
olfactory receptor 4E and related proteins, member of the class A family of ...
20-148 1.65e-04

olfactory receptor 4E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4E and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320606 [Multi-domain]  Cd Length: 267  Bit Score: 42.81  E-value: 1.65e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRkIKTNYFIVSLAFADLLVSVLVMPFGAIELVQD---IWFYGemfCLVR 96
Cdd:cd15940     1 LAFFMLFLVLYLLTLSGNILIMITIVMDPRLH-TPMYFFLSNLSFIDICHSSVTVPKMLSDLLSEektISFNG---CVTQ 76
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1938531436  97 TSLDVLLTTASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVI 148
Cdd:cd15940    77 LFFLHLFACTEIFLLTIMAYDRYVAI-CNPLHYPTVMNHKVCLWLVAALWLG 127
7tmA_OR5D-like cd15410
olfactory receptor subfamily 5D and related proteins, member of the class A family of ...
20-155 1.91e-04

olfactory receptor subfamily 5D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5D, 5L, 5W, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320532  Cd Length: 294  Bit Score: 43.03  E-value: 1.91e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIKtnYFIVS-LAFADLLVSVLVMPFGAIELV---QDIWFYGemfCLV 95
Cdd:cd15410    14 VPLFLVFLAIYGITLLGNLGMIVLIKIDPKLHTPM--YFFLShLSFVDFCYSSVIAPKMLVNFLaedKAISYSG---CML 88
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  96 RTSLDVLLTTASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVIPMFISFL 155
Cdd:cd15410    89 QFFFFCTFVVTESFLLAVMAYDRYVAI-CNPLLYTVIMSRKLCVLLVAGSYLWGIVCSLI 147
7tmA_ET-BR cd15976
endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
28-323 1.92e-04

endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320642 [Multi-domain]  Cd Length: 296  Bit Score: 42.92  E-value: 1.92e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  28 MVILMAILGNLLVMVAVCRDRQLRKiKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSLDVLLTTAS 107
Cdd:cd15976     9 LVFVLGIIGNSTLLRIIYKNKCMRN-GPNILIASLALGDLLHIIIDIPINVYKLLAEDWPFGVEMCKLVPFIQKASVGIT 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 108 IFHLCCISLDRYYAICCQPLVyRNKMTPLRIALMLGGCWVI------PMFISFLPIMQGWNN----IGIVDVIEKRKFNH 177
Cdd:cd15976    88 VLSLCALSIDRYRAVASWSRI-KGIGVPKWTAVEIVLIWVVsiilavPEAIGFDMITMDYKGellrICLLHPIQKTAFMQ 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 178 NSNSTFCVFMVNKPYAITCSVVAFYipFLLMVLAYYRiyvtaKEHAQQIQMlqragatsesrpqtadqhsTHRMRTETKA 257
Cdd:cd15976   167 FYKTAKDWWLFSFYFCLPLACTAVF--YTLMTCEMLR-----KKNGMQIAL-------------------NDHLKQRREV 220
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1938531436 258 AKTLCVIMGCFCFCWAPFFVTNIVD-PFIDYTVPEK--VWTAFLWLGYI-------NSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15976   221 AKTVFCLVLVFALCWLPLHLSRILKlTIYDEKDPNRceLLSFFLVLDYIginmaslNSCINPIALYLVSKRFKNCF 296
7tmA_FFAR cd14983
free fatty acid receptors, member of the class A family of seven-transmembrane G ...
22-323 2.03e-04

free fatty acid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the free fatty acid receptors (FFARs) which bind free fatty acids (FFAs). They belong to the class A G-protein coupled receptors and are composed of three members, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFAR1 is a receptor for medium- and long-chain FFAs, whereas FFAR2 and FFAR3 are receptors for short chain FFAs (SCFAs), which have different ligand affinities. FFAR1 directly mediates FFA stimulation of glucose-stimulated insulin secretion and also indirectly increases insulin secretion by enhancing the release of incretin. FFAR2 activation by SCFA suppresses adipose insulin signaling, which leads to the inhibition of fat accumulation in adipose tissue. FAAR3 is expressed in intestinal L cells, which produces glucagon-like peptide 1 (GLP-1) and peptide YY (PYY), suggesting that this receptor may be involved in energy homeostasis. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320114 [Multi-domain]  Cd Length: 278  Bit Score: 42.81  E-value: 2.03e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  22 LLTFFAMVILMAILGNLLVMVAVCRDRQLRKIKTNYFIVSLAFADLLVsVLVMPFGAIELVQDIWFYGEMFCLVRTSLDV 101
Cdd:cd14983     3 SLMVYVLTILLGLPSNLLALYAFVNRARLRLTPNVIYMINLCLSDLVF-ILSLPIKIVEALSSAWTLPAVLCPLYNLAHF 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 102 LLTTASIFHLCCISLDRYYAICCqPLVYRNKMTPLRIALMLGGCWVIPMF-ISFLPIMQ---GWNNIGIvdviekrkFNH 177
Cdd:cd14983    82 STLYASTCFLTAISAGRYLGVAF-PIKYQLYKKPLYSCLVCVAIWALVIFhVTLVFILEtsgGTLDINT--------PVG 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 178 NSNSTFCVFMVNK-----PYAITCSVVAFYIPFLLMVLAYY---RIYVTAKEHAQQiqmlqragatsesrpqtadqhsth 249
Cdd:cd14983   153 NSSTCYENFTPEQlallaPVRLELSLVLFFLPLAITAFCYVrciRILVRSRLHERR------------------------ 208
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1938531436 250 RMRTETKAAKTLCVimgcFCFCWAPFFVTNIVdpfiDYTVPEKVWTAFLWL--GYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd14983   209 KRRAVRVAVSTLLT----FVVCFGPYNISHVV----GFVRHESVWWRKLALltSTCNAFLDPLIFYFLSSSMERGF 276
7tmA_OR6N-like cd15914
olfactory receptor OR6N and related proteins, member of the class A family of ...
20-147 2.36e-04

olfactory receptor OR6N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6N, 6K, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320580 [Multi-domain]  Cd Length: 270  Bit Score: 42.36  E-value: 2.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRkIKTNYFIVSLAFADL---LVSVLVMPFGAIELVQDIWFYGemfCLVR 96
Cdd:cd15914     1 LLLFILLLLIYLFIITGNLLIFTVVRLDTHLH-TPMYFFISILSFLEIwytTVTIPKMLSNLLSEEKTISFNG---CLLQ 76
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1938531436  97 TSLDVLLTTASIFHLCCISLDRYYAICcQPLVYRNKMTPLRIALMLGGCWV 147
Cdd:cd15914    77 MYFFHSLGITECYLLTAMAYDRYLAIC-NPLHYPSIMTPKLCTQLAAGCWL 126
7tmA_OR52I-like cd15950
olfactory receptor subfamily 52I and related proteins, member of the class A family of ...
26-141 3.64e-04

olfactory receptor subfamily 52I and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52I and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320616  Cd Length: 275  Bit Score: 42.02  E-value: 3.64e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  26 FAMVILMAILGNLLVMVAVCRDRQLRKiKTNYFIVSLAFADLLVSVLVMPfgaiELVQDIWFY----GEMFCLVRTSLDV 101
Cdd:cd15950     7 FCSMYVIALLGNGTILLVIKLDPSLHE-PMYYFLCMLAVIDLVMSTSIVP----KMLSIFWLGsaeiSFEACFTQMFFVH 81
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1938531436 102 LLTTASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALM 141
Cdd:cd15950    82 SFTAVESGVLLAMAFDRYVAI-CHPLRYSAILTSQVIAQI 120
7tmA_OR2_unk cd15424
olfactory receptor family 2, unknown subfamily, member of the class A family of ...
20-153 3.91e-04

olfactory receptor family 2, unknown subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents an unknown subfamily, conserved in some mammalia and sauropsids, in family 2 of olfactory receptors. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320544 [Multi-domain]  Cd Length: 277  Bit Score: 41.64  E-value: 3.91e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKiKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSL 99
Cdd:cd15424     1 ILLFVVILIIYLLTILGNLVIIILVQTDSRLHT-PMYFFLSHLAGLEICYVTSTLPQMLAHLLAGNGAISFARCTTQMYI 79
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1938531436 100 DVLLTTASIFHLCCISLDRYYAICcQPLVYRNKMTPLRIALMLGGCWVIPMFIS 153
Cdd:cd15424    80 ALSLGSTECLLLGAMAYDRYLAIC-HPLLYAAAMGRWRQLQLALSCWAIGFLLS 132
7tmA_OR52B-like cd15221
olfactory receptor subfamily 52B and related proteins, member of the class A family of ...
25-149 4.15e-04

olfactory receptor subfamily 52B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor (OR) subfamilies 52B, 52D, 52H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320349  Cd Length: 275  Bit Score: 41.89  E-value: 4.15e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  25 FFAMVILmAILGNLLVMVAVCRDRQLRKiKTNYFIVSLAFADLLVSVLVMP-------FGAielvQDIWFYG---EMFCL 94
Cdd:cd15221     7 FCSMYIV-ALLGNSLLLFVIVTERSLHE-PMYLFLSMLAVTDLLLSTTTVPkmlaifwFGA----GEISFDGcltQMFFV 80
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1938531436  95 VRTSL---DVLLTTAsifhlccisLDRYYAIcCQPLVYRNKMTPLRI------ALMLGGCWVIP 149
Cdd:cd15221    81 HFVFVtesAILLAMA---------FDRYVAI-CYPLRYTTILTHSVIgkigvaAVARSFCIVFP 134
PHA02834 PHA02834
chemokine receptor-like protein; Provisional
22-328 4.47e-04

chemokine receptor-like protein; Provisional


Pssm-ID: 165177  Cd Length: 323  Bit Score: 41.81  E-value: 4.47e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  22 LLTFFAMVILMAILGNLLVMVAVCRDRQLRKIktNYFIVSLAFADLLVsVLVMPFgAIELVQDIWFYGEMFCLVRTSLDV 101
Cdd:PHA02834   31 VIVFYILLFIFGLIGNVLVIAVLIVKRFMFVV--DVYLFNIAMSDLML-VFSFPF-IIHNDLNEWIFGEFMCKLVLGVYF 106
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 102 LLTTASIFHLCCISLDRYYAICCQPLVyRNKMTPLRIALMLgGCWVIPMFISfLPIMQGW---NNIGIVDVIEKRKFNHN 178
Cdd:PHA02834  107 VGFFSNMFFVTLISIDRYILVVNATKI-KNKSISLSVLLSV-AAWVCSVILS-MPAMVLYyvdNTDNLKQCIFNDYHENF 183
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 179 SNSTFCVFMVNkpyaitcsVVAFYIPFLLMVLAYYRIYVTAKehaqqiqmlqragatsesrpqtadqhsTHRMRTETKAA 258
Cdd:PHA02834  184 SWSAFFNFEIN--------IFGIVIPLIILIYCYSKILYTLK---------------------------NCKNKNKTRSI 228
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 259 KTLCVIMGCFCFCWAPFFVTNIVDP-----FID---YTVPEKVWTAFL--WLGYINSGLNPFLYAFLNKSFRRAFLIILC 328
Cdd:PHA02834  229 KIILTVVTFTVVFWVPFNIVLFINSlqsvgLIDigcYHFKKIVYSIDIaeLISFVHCCVNPIIYAFVGKNFKKVFKNMFC 308
7tmA_CysLTR1 cd15158
cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G ...
24-321 5.14e-04

cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320286 [Multi-domain]  Cd Length: 285  Bit Score: 41.65  E-value: 5.14e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  24 TFFAMVILMAILGNLLVMVAVCRDRQlRKIKTNYFIVSLAFADLLVsVLVMPFGAIELV-QDIWFYGEMFCLVRTSLDVL 102
Cdd:cd15158     5 TLYSVITVFGLVGNGFALYVLIKTYR-QKSAFHIYMLNLAVSDLLC-VCTLPLRVVYYVhKGQWLFGDFLCRISSYALYV 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 103 LTTASIFHLCCISLDRYYAICCqPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMQGWNNigivDVIEKRKFNHNSNST 182
Cdd:cd15158    83 NLYCSIYFMTAMSFTRFLAIVF-PVQNLNLVTVKKARIVCVGIWIFVTLTSSPFLMSGSHD----TETNKTKCFEPPQSN 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 183 FCVFMVNKPYAITCsVVAFYIPFLLMVLAYYRIYVTakehaqqiqMLQRagaTSESRPQTAdqhsthrmrTETKAAKTLC 262
Cdd:cd15158   158 QQLTKLLVLNYISL-VVGFIIPFLVILICYAMIIRT---------LLKN---TMKARKQQS---------SRKKAIRMII 215
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1938531436 263 VIMGCFCFCWAPF---------FVTNIVDPFIDYTVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRR 321
Cdd:cd15158   216 IVLLAFLVSFMPYhiqrtihlhFLSRKDSTCEEVLYMQKSVVITLCLAAANCCFDPLLYFFSGENFRR 283
7tmA_OR52R_52L-like cd15951
olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of ...
26-161 5.52e-04

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 52R, 52L and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320617  Cd Length: 275  Bit Score: 41.18  E-value: 5.52e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  26 FAMVILMAILGNLLVMVAVCRDRQLRKiKTNYFIVSLAFADLLVSVLVMPfgaiELVQDIWF-YGEM---FCLVRTSLDV 101
Cdd:cd15951     7 FCIMYAVALLGNFTILFIVKTEPSLHE-PMYLFLCMLAITDLVLSTSTLP----KMLSIFWFnSREIdfsACLTQMFFIH 81
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1938531436 102 LLTTASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIA------LMLGGCWVIPMfisflPIMQGW 161
Cdd:cd15951    82 SFSTMESGIFVAMALDRYVAI-CNPLRHSTILTNSVVAkiglavVLRGGILVSPH-----PFLLRR 141
7tmA_OR5AR1-like cd15944
olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of ...
19-143 5.64e-04

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AR1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320610 [Multi-domain]  Cd Length: 294  Bit Score: 41.31  E-value: 5.64e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  19 KVVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKiKTNYFIVSLAFADLLVSVLVMPFGAIELV---QDIWFYGemfCLV 95
Cdd:cd15944    13 QIILFVVFLIIYLVNVVGNLGMIILITTDSQLHT-PMYFFLCNLSFCDLGYSSAIAPRMLADFLtkhKVISFSG---CAT 88
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1938531436  96 RTSLDVLLTTASIFHLCCISLDRYYAIcCQPLVYRNKMTP-LRIALMLG 143
Cdd:cd15944    89 QFAFFVGFVDAECYVLAAMAYDRYVAI-CNPLLYSTLMSKrVCLQLMAG 136
7tmA_OR52P-like cd15953
olfactory receptor subfamily 52P and related proteins, member of the class A family of ...
26-141 6.81e-04

olfactory receptor subfamily 52P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52P and related proteins in other mammals, sauropsids and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 341354  Cd Length: 275  Bit Score: 41.09  E-value: 6.81e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  26 FAMVILMAILGNLLVMVAVCRDRQLRKiKTNYFIVSLAFADLLVSVLVMP-------FGAielvQDIWFYGemfCLVRTs 98
Cdd:cd15953     7 FCLMYIVTLLGNCTILFVVGKEQSLHK-PMYLLLCMLALTDLVLSTSVVPkalcifwFNL----KEITFSG---CLTQM- 77
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1938531436  99 ldVLLTTASIFH---LCCISLDRYYAIcCQPLVYRNKMTPLRIALM 141
Cdd:cd15953    78 --FFIHTLSIMEsavLVAMAFDRYVAI-CNPLRYATILTNSRIAKL 120
7tmA_Retinal_GPR cd15072
retinal G protein coupled receptor, member of the class A family of seven-transmembrane G ...
24-320 7.10e-04

retinal G protein coupled receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the retinal G-protein coupled receptor (RGR) found exclusively in retinal pigment epithelium (RPE) and Muller cells. RGR is a member of the class A rhodopsin-like receptor family. As with other opsins, RGR binds all-trans retinal and contains a conserved lysine reside on the seventh helix. RGR functions as a photoisomerase to catalyze the conversion of all-trans-retinal to 11-cis-retinal. Two mutations in RGR gene are found in patients with retinitis pigmentosa, indicating that RGR is essential to the visual process.


Pssm-ID: 320200 [Multi-domain]  Cd Length: 260  Bit Score: 40.81  E-value: 7.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  24 TFFAMVILMAILGNLLVMVAVCRDRQLRKiKTNYFIVSLAFADLLVSV--LVMPFGAIelvQDIWFYGEMFCLVRTSLDV 101
Cdd:cd15072     5 SILLVEALVGFSLNGLTILSFCKTRELRT-PSNLLVLSLAVADMGISLnaLVAASSSL---LRRWPYGSEGCQAHGFQGF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 102 LLTTASIFHLCCISLDRYYAICcqplvYRNKMTPLRIALMLGGCWVIPMFISFLPIMqGWNN-----IGIVDVIEKRKFN 176
Cdd:cd15072    81 FTALASICSSAAIAWDRYHHYC-----TRSKLQWSTAISLVLFVWLFSAFWAAMPLL-GWGEydyepLGTCCTLDYSKGD 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 177 HNSNStfcvfmvnkpYAITCSVVAFYIPFLLMVLAYYRIYVTAKehaqqiqmlqragatsesrpqtadqhSTHRMRTETK 256
Cdd:cd15072   155 RNYVS----------YLFTMAFFNFILPLFILLTSYSSIEQKLK--------------------------KEGHLRFNTG 198
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1938531436 257 A-AKTLcvimgcfCFCWAPFFVTNIVDPFIDYTVPEKVWTAFL-WLGYINSGLNPFLYAFLNKSFR 320
Cdd:cd15072   199 LpLLTL-------LICWGPYAILALYAAITDVTSISPKLRMVPaLLAKTSPTINAILYALGNENYR 257
7tmA_ET_R cd15128
endothelin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
28-323 7.35e-04

endothelin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are 21-amino acid peptides which able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320256 [Multi-domain]  Cd Length: 300  Bit Score: 40.97  E-value: 7.35e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  28 MVILMAILGNLLVMVAVCRDRQLRKiKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYG-EMFCLVRTSLDVLLTTA 106
Cdd:cd15128     9 LIFIVGIIGNSTLLRIIYQNKCMRN-GPNALIASLALGDLLYIVIDLPINVYKLLAMDWPFGdQPFGQFLCKLVPFIQKA 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 107 S----IFHLCCISLDRYYAICCQPLVYRNKMtPLRIALMLGGCWVIPMFISfLPIMQGWNNIgivdviekrKFNHnSNST 182
Cdd:cd15128    88 SvgitVLNLCALSVDRYRAVASWSRIQGIGI-PMWTAVEIVMIWMLSAVLA-VPEAIGFDMV---------RFNY-KGVT 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 183 FCVFMVNKpyaiTCSVVAFYIPF---------LLMVLAYYRIYVTAKEHaqqiQMLQRagATSESRPQTADQhsthrMRT 253
Cdd:cd15128   156 LRTCLLRP----ETSFMKFYIDVkdwwlfgfyFCLPLVCTAIFYTLMTC----EMLRK--RNGMLRIALNEH-----LKQ 220
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 254 ETKAAKTLCVIMGCFCFCWAPFFVTNIVDPFI-DYTVPEK--VWTAFLWLGYI-------NSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15128   221 RREVAKTVFCLVVIFALCWLPLHLSRILKLTVyDQNDPNRceLLSFLLVLDYFginlatlNSCINPIALYFVSRKFKNCF 300
7tmA_SWS1_opsin cd15076
short wave-sensitive 1 opsins, member of the class A family of seven-transmembrane G ...
25-320 8.37e-04

short wave-sensitive 1 opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Short Wave-Sensitive opsin 1 (SWS1), which mediates visual transduction in response to light at short wavelengths (ultraviolet to blue). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320204 [Multi-domain]  Cd Length: 280  Bit Score: 40.96  E-value: 8.37e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  25 FFAMVILMAILGNLLVMVAVCRDRQLRKiKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSLDVLLT 104
Cdd:cd15076     6 FMGFVFIVGTPLNAIVLFVTIKYKKLRQ-PLNYILVNISLAGFIFCIFSVFPVFVASAQGYFFFGRTVCALEAFVGSLAG 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 105 TASIFHLCCISLDRYYAICcQPlvYRNKMTPLRIALMLGGC-WVIPMFISfLPIMQGWN---------NIGIVDVIEKRK 174
Cdd:cd15076    85 LVTGWSLAFLAFERYIVIC-KP--FGNFRFGSKHALGAVVAtWIIGIGVS-LPPFFGWSryipeglqcSCGPDWYTVGTK 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 175 FNHNSNSTFCVfmvnkpyaITCsvvaFYIPFLLMVLAYYRIYVTAKEHAQQiqmlqragatsesrpqtaDQHSTHRMRTE 254
Cdd:cd15076   161 YRSEYYTWFLF--------IFC----FIVPLSIIIFSYSQLLGALRAVAAQ------------------QQESASTQKAE 210
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1938531436 255 TKAAKTLCVIMGCFCFCWAPF-----FVTNIVDPFIDY---TVPekvwtAFlwLGYINSGLNPFLYAFLNKSFR 320
Cdd:cd15076   211 REVSRMVVVMVGSFCLCYVPYaalamYMVNNRDHGLDLrlvTIP-----AF--FSKSSCVYNPIIYCFMNKQFR 277
7tmA_GPER1 cd14989
G protein-coupled estrogen receptor 1, member of the class A family of seven-transmembrane G ...
35-320 9.05e-04

G protein-coupled estrogen receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled estrogen receptor 1 (GPER1), also known as the G-protein coupled receptor 30 (GPR30), is a high affinity receptor for estrogen. This receptor is a member of the class A of seven-transmembrane GPCRs. Estrogen binding results in intracellular calcium mobilization and synthesis of phosphatidylinositol (3,4,5)-trisphosphate in the nucleus. GPR30 plays an important role in development of tamoxifen resistance in breast cancer cells. The distribution of GPR30 is well established in the rodent, with high expression observed in the hypothalamus, pituitary gland, adrenal medulla, kidney medulla and developing follicles of the ovary. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320120 [Multi-domain]  Cd Length: 276  Bit Score: 40.58  E-value: 9.05e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  35 LGNLLVMVAVCRDRQLRKIKTNYFIvSLAFADLLVSV--LVMPFGAIELVQDIwfygEMFCLVRTSLDVLLTTASIFHLC 112
Cdd:cd14989    16 IGNILILVVNLSFREKMTIPDLYFV-NLAVADLILVAdsLIEVFNLNEKYYDI----AVLCTFMSLFLQINMYSSIFFLT 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 113 CISLDRYYAiccqpLVYRNKMTPLRIA----LMLGGCWVIPMFISFLPIMqgwnnigIVDViekrkfNHNSNSTFCVFMV 188
Cdd:cd14989    91 WMSFDRYIA-----LAKVMKSSPLRTMqharLSCGLIWMASISATLLPFT-------AVQA------QHTGEVHFCFADV 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 189 NKPYAITCSVvAFYIPFLLMVLAYYRIyvtakehaqqIQMLQRAgatsesrpqtaDQHSTHRMRTEtKAAKTLCVIMGCF 268
Cdd:cd14989   153 REIQWLEVTL-GFIIPFSIIGLCYSLI----------VRVLVRA-----------QKHRRLRPRRQ-KALRMILVVVLVF 209
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1938531436 269 CFCWAP---FFVTNIV----DPFIDYtvPEKVWTAFLWLGYI-------NSGLNPFLYAFLNKSFR 320
Cdd:cd14989   210 FICWLPenvFISIQLLqgtqEPSESY--DESFRHNHPLTGHIvnlaafsNSCLNPLIYSFLGETFR 273
7tmA_NAGly_R_GPR18 cd15166
N-arachidonyl glycine receptor, GPR18, member of the class A family of seven-transmembrane G ...
23-148 9.37e-04

N-arachidonyl glycine receptor, GPR18, member of the class A family of seven-transmembrane G protein-coupled receptors; N-arachidonyl glycine (NAGly), an endogenous metabolite of the endocannabinoid anandamide, has been identified as an endogenous ligand of the G(i/o) protein-coupled receptor 18 (GPR18). NAGly is involved in directing microglial migration in the CNS through activation of GPR18. NAGly-GPR18 signaling is thought to play an important role in microglial-neuronal communication. Recent studies also show that GPR18 functions as the abnormal cannabidiol (Abn-CBD) receptor. Abn-CBD is a synthetic isomer of cannabidiol and is inactive at cannabinoid receptors (CB1 or CB2), but acts as a selective agonist at GPR18. The NAGly receptor is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320294 [Multi-domain]  Cd Length: 275  Bit Score: 40.58  E-value: 9.37e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  23 LTFFAMVILMAILGNLLVM-VAVCRDRqlRKIKTNYFIVSLAFADLlVSVLVMPFGAIELVQDIWFYGEMFCLVRTSLDV 101
Cdd:cd15166     4 LVFYSFIFIIGLFVNITALwVFSCTTK--KRTTVTVYMMNVALVDL-IFILSLPFRMVYYAKDEWPFGDYFCRILGALTV 80
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1938531436 102 LLTTASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVI 148
Cdd:cd15166    81 FYPSIALWLLAFISADRYMAI-VQPKHAKELKNTPKAVLACVGVWIM 126
7tmA_OR2F-like cd15429
olfactory receptor subfamily 2F and related proteins, member of the class A family of ...
22-218 9.76e-04

olfactory receptor subfamily 2F and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320546 [Multi-domain]  Cd Length: 277  Bit Score: 40.46  E-value: 9.76e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  22 LLTFFAMVILMAILGNLLVMVAVCRDRQLRkIKTNYFIVSLAFADLLVSVLVMPFGAIELVQD---IWFYGemfCLVRTS 98
Cdd:cd15429     3 LFVLFLVMYLLTLLGNFLIILLIRLDPRLH-TPMYFFLSHLSFLDICYTTSVVPQMLAHFLAEhktISFAS---CVAQLF 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  99 LDVLLTTASIFHLCCISLDRYYAICcQPLVYRNKMTPLRIALMLGGCW--------VIPMFISFLPiMQGWNNIgivdvi 170
Cdd:cd15429    79 ISLALGGTEFILLAVMAYDRYVAVC-HPLRYTVIMSGGLCIQLAAASWtsgflnslVQTAFTFRLP-FCGHNTI------ 150
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1938531436 171 ekrkfNHNSNSTFCVF-------MVNKPYAITCSVVAFYIPFLLMVLAYYRIYVT 218
Cdd:cd15429   151 -----NHFSCELLAVVrlacvdtSLNEVAILVSSVVVLLTPCFLVLLSYIHIISA 200
7tmA_LPAR5 cd15154
lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G ...
21-323 1.26e-03

lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 5 (LPAR5) is a G protein-coupled receptor that binds the bioactive lipid lysophosphatidic acid (LPA) and is involved in maintenance of human hair growth. Phylogenetic analysis of the class A GPCRs shows that LAPR5 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(q) and G(12/13) proteins.


Pssm-ID: 320282 [Multi-domain]  Cd Length: 285  Bit Score: 40.13  E-value: 1.26e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  21 VLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIkTNYFIVSLAFADLLVSvLVMPFGAIELVQDIWFYGEMFCLVRTSLD 100
Cdd:cd15154     2 LHLVGYSLLFPVGLLLNAVALWVFVRYLRLHSV-VSIYMCNLALSDLLFT-LSLPLRIYYYANHYWPFGNFLCQFSGSIF 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 101 VLLTTASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVIpmfisflpIMQGWNNIGIV-DVIEKRKFNHNS 179
Cdd:cd15154    80 QMNMYGSCLFLMCINVDRYLAI-VHPLRFRHLRRPKVARLLCLAVWAL--------ILGGSVPAAIVhSSSDCLLHGEKV 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 180 NSTFCVFMVNK-----PYAITCSVVAFYIPFLLMVLAYYRIYVTakehaqqiqmLQRAGATSESRPQtadqhsthrmrte 254
Cdd:cd15154   151 YRCFESFSDNDwkgllPLVVLAEILGFLLPLAAVLYCSCRIFVE----------LCRTQEPQQGRRR------------- 207
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1938531436 255 tKAAKTLCVIMGCFCFCWAPFFVTNIV-----DPFIDYTVPEK-----VWTAFLWLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15154   208 -KTVRLLLVNLVIFLICFVPYNTTLAVygllrANLVEDTWNIKdtlrkVLSVTVLLASTNCALDPLVYYFSTEGFRNTL 285
7tmA_OR5A1-like cd15417
olfactory receptor subfamily 5A1 and related proteins, member of the class A family of ...
20-154 1.30e-03

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5A1, 5A2, 5AN1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320539  Cd Length: 279  Bit Score: 40.32  E-value: 1.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRkIKTNYFIVSLAFADLLVSVLVMPFGAIELVQD---IWFYGemfCLVR 96
Cdd:cd15417     1 IILFVLFLGIYLVTLLWNLGLIILIRMDSHLH-TPMYFFLSNLSFVDICYSSSITPKMLSDFFREqktISFVG---CATQ 76
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1938531436  97 TSLDVLLTTASIFHLCCISLDRYYAICcQPLVYRNKMTPLRIALMLGGCWVIPMFISF 154
Cdd:cd15417    77 YFVFSGMGLTECFLLAAMAYDRYVAIC-NPLLYSVIMSPRLCVQLVAGAYLGGFLNSL 133
7tmA_FFAR2_FFAR3 cd15170
free fatty acid receptors 2, 3, and similar proteins, member of the class A family of ...
21-323 1.53e-03

free fatty acid receptors 2, 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes free fatty acid receptor 2 (FFAR2), FFAR3, and similar proteins. They are a member of the class A G-protein coupled receptors that bind free fatty acids. The FFAR subfamily is composed of three receptors, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFAR2 and FFAR3 are cell-surface receptors for short chain FFAs (SCFAs) with different ligand affinities, whereas FFAR1 is a receptor for medium- and long-chain FFAs. FFAR2 activation by SCFA suppresses adipose insulin signaling, which leads to inhibition of fat accumulation in adipose tissue. FAAR3 is expressed in intestinal L cells, which produces glucagon-like peptide 1 (GLP-1) and peptide YY (PYY), thus suggesting that this receptor may be involved in energy homeostasis. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320298  Cd Length: 278  Bit Score: 39.94  E-value: 1.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  21 VLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIKTNYFIVSLAFADLLVsVLVMPFGAIELV-QDIWFYGEMFCLVRTSL 99
Cdd:cd15170     2 LVLAVYIITFLIGLPANLLAFYTFIRKVRRKPTPIDILLLNLTVSDLIF-LLFLPFKMAEAAsGMIWPLPYFLCPLSSFI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 100 DVLLTTASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVIPMFisflpimqgwnNIGIVDVIEKRKFNHNS 179
Cdd:cd15170    81 FFSTIYISTLFLTAISVERYLGV-AFPIKYKLRRRPLYAVIASVFFWVLAFS-----------HCSIVYIVEYHIDSENT 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 180 NST-----FCVFMVNK-----PYAITCSVVAFYIPFLLMVLAYYRIyvtakehaqqIQMLQRAGATSESRpqtadqhsth 249
Cdd:cd15170   149 SVTnnsrcYDNFTPEQlkillPVRLELFLVLFCIPFLITCFCYINF----------IRILSSLPHISRQR---------- 208
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1938531436 250 RMRTETKAAKTLCVimgcFCFCWAPFFVTNIVDpFIDYTVPEKVWTAFLwLGYINSGLNPFLYAFLNKSFRRAF 323
Cdd:cd15170   209 KQRAIGLAVATLLN----FIVCFAPYNISHVVG-FIQRKSPEWRMYALL-LSTLNACLDPIIFYFSSSAVRRAF 276
7tmA_OR52E-like cd15952
olfactory receptor subfamily 52E and related proteins, member of the class A family of ...
26-157 1.53e-03

olfactory receptor subfamily 52E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52E and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320618  Cd Length: 274  Bit Score: 40.06  E-value: 1.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  26 FAMVILMAILGNLLVMVAVCRDRQLRKiKTNYFIVSLAFADLLVSVLVMP-------FGAielvQDIWFYGemfCLVRTS 98
Cdd:cd15952     7 FCAVYLIALLGNCTILFVIKTEQSLHQ-PMFYFLAMLSTIDLGLSTATIPkmlgifwFNL----REISFGG---CLAQMF 78
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1938531436  99 LDVLLTTASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMlGGCWVIPMFISFLPI 157
Cdd:cd15952    79 FIHTFTGMESAVLVAMAFDRYVAI-CNPLRYTTILTNKVISVI-ALGIVLRPLLLVLPF 135
7tmA_OR5B-like cd15407
olfactory receptor subfamily 5B and related proteins, member of the class A family of ...
20-148 2.25e-03

olfactory receptor subfamily 5B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320529  Cd Length: 279  Bit Score: 39.33  E-value: 2.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKiKTNYFIVSLAFADLLVSVLVMP-FGAIELVQD--IWFYGemfCLVR 96
Cdd:cd15407     1 IPLFIIFTLIYLITLVGNLGMILLILLDSRLHT-PMYFFLSNLSLVDIGYSSAVTPkVMAGLLTGDkvISYNA---CAAQ 76
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1938531436  97 TSLDVLLTTASIFHLCCISLDRYYAICcQPLVYRNKMTPLRIALMLGGCWVI 148
Cdd:cd15407    77 MFFFVVFATVENFLLASMAYDRHAAVC-KPLHYTTTMTTKVCACLTIGCYVC 127
7tmA_ETBR-LP2 cd15126
endothelin B receptor-like protein 2, member of the class A family of seven-transmembrane G ...
20-122 2.41e-03

endothelin B receptor-like protein 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelin B receptor-like protein 2, also called GPR37L1, is almost exclusively expressed in the nervous system. It has recently been shown to act as a receptor for the neuropeptide prosaptide, the active fragment of the secreted neuroprotective and glioprotective factor prosaposin (also called sulfated glycoprotein-1). Both prosaptide and prosaposin protect primary astrocytes against oxidative stress. GPR37L1 is part of the class A family of GPCRs that includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320254  Cd Length: 298  Bit Score: 39.46  E-value: 2.41e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFfaMVILMAILGNLLVMVAVCRDRQLRKiKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSL 99
Cdd:cd15126     3 ILLLAL--VVFAVGIVGNLSVMCIVWHSYYLKS-AWNSILASLALWDFLVLFFCLPVVVFNEITKKRLLGDVSCRVVPYM 79
                          90       100
                  ....*....|....*....|...
gi 1938531436 100 DVLLTTASIFHLCCISLDRYYAI 122
Cdd:cd15126    80 EVTSLGVTTFSLCALGIDRFHAA 102
7tmA_P2Y2 cd15373
P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled ...
20-321 2.43e-03

P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y2 belongs to the P2Y receptor family of purinergic G-protein coupled receptors and is implicated to play a role in the control of the cell cycle of endometrial carcinoma cells. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320495 [Multi-domain]  Cd Length: 283  Bit Score: 39.35  E-value: 2.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVM-VAVCRDRQLRKIKTnyFIVSLAFADLLVsVLVMPFgaieLV-----QDIWFYGEMFC 93
Cdd:cd15373     1 ILLPVSYGIVFVVGLVLNILALyVFLFRTKPWNASTT--YMFNLAISDTLY-VLSLPL----LVyyyadENDWPFSEALC 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  94 LVRTSLDVLLTTASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWVIPM-----FISFLPIMQGWNNIGIVD 168
Cdd:cd15373    74 KIVRFLFYTNLYCSILFLLCISVHRFLGV-CYPVRSLRWLKVRYARIVSVVVWVIVLacqspVLYFVTTSDKGGNITCHD 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 169 VIEKRKFNHnsnstfcvFMVnkpYAITCSVVAFYIPFLLMVLAYYRIYVTakehaqqiqMLQRAGATSESRpqtadqhst 248
Cdd:cd15373   153 TSSPELFDQ--------FVV---YSSVMLVLLFCVPFVVILVCYALMVRK---------LLKPSAGTSTNS--------- 203
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 249 hrmRTETKAAKTLCVIMGCFCFCWAPFFVTNIVDPFIDYT-----------VPEKVWTAflwLGYINSGLNPFLYAFLNK 317
Cdd:cd15373   204 ---RSKKKSVKMIIIVLAVFILCFLPFHVTRTLYYSFRSMdlscgtlnainLAYKVTRP---LASANSCLDPILYFLAGQ 277

                  ....
gi 1938531436 318 SFRR 321
Cdd:cd15373   278 SFRS 281
7tmA_PAR1 cd15369
protease-activated receptor 1, member of the class A family of seven-transmembrane G ...
24-122 2.43e-03

protease-activated receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320491  Cd Length: 281  Bit Score: 39.36  E-value: 2.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  24 TFFAMVILMAILGNLLVMVAVCRDRQLRKIKTNYfIVSLAFADLLVsVLVMPFG-AIELVQDIWFYGEMFCLVRTSLDVL 102
Cdd:cd15369     5 SVYTIVFVISLPLNILALVVFLRKMRVKKPAVIY-MLNLACADLLF-VLLLPFKiAYHFSGNDWLFGEAMCRVVTAAFYC 82
                          90       100
                  ....*....|....*....|
gi 1938531436 103 LTTASIFHLCCISLDRYYAI 122
Cdd:cd15369    83 NMYCSILLMTCISVDRFLAV 102
7tmA_OR9G-like cd15418
olfactory receptor subfamily 9G and related proteins, member of the class A family of ...
19-134 2.52e-03

olfactory receptor subfamily 9G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 9G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320540 [Multi-domain]  Cd Length: 281  Bit Score: 39.38  E-value: 2.52e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  19 KVVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKiKTNYFIVSLAFADLLVSVLVMPFGAIELVQD---IWFYGemfCLV 95
Cdd:cd15418     1 QLILFVVFLLSYILTLVGNLTLIALICLDSRLHT-PMYFFVGNLSFLDLWYSSVYTPKILADCISKdksISFAG---CAA 76
                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1938531436  96 RTSLDVLLTTASIFHLCCISLDRYYAIcCQPLVYRNKMT 134
Cdd:cd15418    77 QFFFSAGLAYSECFLLAAMAYDRYVAI-CNPLLYSSAMS 114
7tmA_RXFP1_LGR7 cd15965
relaxin receptor 1 (or LGR7), member of the class A family of seven-transmembrane G ...
20-320 3.10e-03

relaxin receptor 1 (or LGR7), member of the class A family of seven-transmembrane G protein-coupled receptors; Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four G protein-coupled receptors, RXFP1-4. Relaxin is the endogenous ligand for RXFP1, which has a large extracellular N-terminal domain containing 10 leucine-rich repeats and a unique low-density lipoprotein type A (LDLa) module which is necessary for receptor activation. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP and nitric oxide. RXFP1 is expressed in various tissues including uterus, ovary, placenta, cerebral cortex, heart, lung and kidney, among others.


Pssm-ID: 320631 [Multi-domain]  Cd Length: 287  Bit Score: 39.08  E-value: 3.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIKTnYFIVSLAFADLLVSVLVMPFGAIelvqDIWFYGE--------- 90
Cdd:cd15965     1 IVQRVFVWVVSAVTCFGNIFVICMRPYIRSENKLHA-MSIISLCCADCLMGIYLFVIGAF----DLKYRGEynkhaqlwm 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  91 --MFCLVRTSLDVLLTTASIFHLCCISLDRYYAI-----CCQPLVYRNKMTPLRIalmlggcWVIPMFISFLPIMQgwnn 163
Cdd:cd15965    76 dsTQCQLVGSLAILSTEVSVLLLTYLTLEKYICIvypfrCLTPGKCRTITILILI-------WIIGFIIAFIPLSN---- 144
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 164 igivdviekRKFNHNSNST--FCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAkeHAQQIQMLQRAGATsesrpq 241
Cdd:cd15965   145 ---------KEFFRNYYGTngVCFPLHSEQPESTGAQIYSVVIFLGLNLAAFIIIVFS--YGSMFYSIHQTAIM------ 207
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 242 tADQHSTHrMRTETKAAKTLCVIMGCFCFCWAPFFVTNIVDpFIDYTVPEKV--WTAFLWLGyINSGLNPFLYAFLNKSF 319
Cdd:cd15965   208 -ATEISNH-IKKEMTLAKRFFFIVFTDALCWIPIFILKLLS-LLQVEIPGTIssWVVIFILP-INSALNPILYTLTTRPF 283

                  .
gi 1938531436 320 R 320
Cdd:cd15965   284 K 284
7tmA_P2Y4 cd15374
P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled ...
86-321 3.53e-03

P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y4 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. This family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320496 [Multi-domain]  Cd Length: 285  Bit Score: 39.02  E-value: 3.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  86 WFYGEMFCLVRTSLDVLLTTASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCW------VIPMFIsFLPIMQ 159
Cdd:cd15374    66 WPFGVVACKIVRFLFYANLYCSILFLTCISVHRYVGI-CHPIRALRWVKPRHAYLICASVWlvvtvcLVPNLI-FVTTSR 143
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 160 GWNNIGIVDVIEKRKFNHNSNstfcvfmvnkpYAITCSVVAFYIPFLLMVLAYyriYVTAKEHAQQIQmlqragatsesr 239
Cdd:cd15374   144 KDNITLCHDTTRPEEFDHYVH-----------YSSAVMVLLFGIPCLVIVVCY---GLMARRLCKPRV------------ 197
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436 240 PQTADQHSTHRMRTetkaAKTLCVIMGCFCFCWAPFFVT-----------------NIVDPFIDYTVPekvwtaflwLGY 302
Cdd:cd15374   198 GSSRQQGPSSKKRS----LKTIIMVLTVFAICFVPFHITrtlyyvarllkadcdtlNIINVTYKVTRP---------LAS 264
                         250
                  ....*....|....*....
gi 1938531436 303 INSGLNPFLYAFLNKSFRR 321
Cdd:cd15374   265 ANSCLDPILYFLAGDKYRR 283
7tmA_OR9K2-like cd15419
olfactory receptor subfamily 9K2 and related proteins, member of the class A family of ...
20-147 3.77e-03

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 9K2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320541  Cd Length: 279  Bit Score: 38.83  E-value: 3.77e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKiKTNYFIVSLAFADLLVSVLVMPFGAIELVQD---IWFYGemfCLVR 96
Cdd:cd15419     1 VLLFLLFLVIYMVTVLGNIGMIIIISTDSRLHT-PMYFFLMNLSFLDLCYSSVIAPKALANFLSEsktISYNG---CAAQ 76
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1938531436  97 TSLDVLLTTASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWV 147
Cdd:cd15419    77 FFFFSLFGTTEGFLLAAMAYDRFIAI-CNPLLYPVIMSRRVCVQLVAGSYL 126
7tmA_OR5J-like cd15415
olfactory receptor subfamily 5J and related proteins, member of the class A family of ...
20-147 6.15e-03

olfactory receptor subfamily 5J and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5J and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320537 [Multi-domain]  Cd Length: 279  Bit Score: 38.16  E-value: 6.15e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKiKTNYFIVSLAFADLLVSVLVMPFGAIELVQD---IWFYGemfCLVR 96
Cdd:cd15415     1 VPLFMLFLLIYFITLLGNLGMIVLIRINPQLHT-PMYFFLSNLSFVDLCYSSVFAPRLLVNFLVEkktISYSA---CIAQ 76
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1938531436  97 TSLDVLLTTASIFHLCCISLDRYYAIcCQPLVYRNKMTPLRIALMLGGCWV 147
Cdd:cd15415    77 HFFFAVFVTTEGFLLAVMAYDRYVAI-CNPLLYTVAMTKRVCVQLVAGSYL 126
7tmA_OR8B-like cd15405
olfactory receptor subfamily 8B and related proteins, member of the class A family of ...
22-148 6.79e-03

olfactory receptor subfamily 8B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320527 [Multi-domain]  Cd Length: 277  Bit Score: 38.17  E-value: 6.79e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  22 LLTFFAMVILMAILGNLLVMVAVCRDRQLRKIKTnYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSLDV 101
Cdd:cd15405     3 LFFLFLGIYVVTVVGNLGLITLICLNSHLHTPMY-FFLFNLSFIDLCYSSVFTPKMLMNFVSEKNTISYAGCMTQLFFFC 81
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1938531436 102 LLTTASIFHLCCISLDRYYAICcQPLVYRNKMTPLRIALMLGGCWVI 148
Cdd:cd15405    82 FFVISECYVLTAMAYDRYVAIC-NPLLYTVTMSPQVCSLLMLGSYVM 127
7tmA_OR2W-like cd15434
olfactory receptor subfamily 2W and related proteins, member of the class A family of ...
20-148 7.15e-03

olfactory receptor subfamily 2W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2W and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320551 [Multi-domain]  Cd Length: 277  Bit Score: 37.74  E-value: 7.15e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  20 VVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKiKTNYFIVSLAFADLLVSVLVMPfgaiELVQDIW-------FYGemf 92
Cdd:cd15434     1 KILSVVVLIFYLLTLVGNTTIILVSCLDSRLHT-PMYFFLANLSFLDLCFTTSIIP----QMLVNLWgpdktisYVG--- 72
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1938531436  93 CLVRTSLDVLLTTASIFHLCCISLDRYYAICcQPLVYRNKMTPLRIALMLGGCWVI 148
Cdd:cd15434    73 CAIQLFIALGLGGTECVLLAVMAYDRYAAVC-QPLHYTVVMHPRLCWKLVAMSWLI 127
7tmA_SUCNR1_GPR91 cd15378
succinate receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
22-242 7.21e-03

succinate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Succinate receptor (SUCNR1) GPR91 exclusively couples to G(i) protein to inhibit cAMP production and also activates PLC-beta to increase intracellular calcium concentrations in an inositol phosphate dependent mechanism. Succinate, an intermediate molecule of the citric cycle, is shown to cause cardiac hypertrophy via GPR91 activation. Furthermore, succinate-induced GPR91 activation is involved in the regulation of renin-angiotensin system and is suggested to play an important role in the development of renovascular hypertension and diabetic nephropathy. SUCNR1 belongs to the class A GPCR superfamily and is phylogenetically related to the purinergic P2Y1-like receptor subfamily, whose members are coupled to G(q) protein to activate phospholipase C (PLC).


Pssm-ID: 320500 [Multi-domain]  Cd Length: 283  Bit Score: 37.77  E-value: 7.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  22 LLTFFAMVILMAILGNLLVMVA--VCrdrqLRKIKT-NYFIVSLAFADLLVsVLVMPFGAIELVQDIWFYGEMFCLV-RT 97
Cdd:cd15378     3 LPTMYSIEFVLGFIGNTIVILGyiFC----LKNWKSsNIYLFNLSVSDLAF-LCTLPMLVYSYSNGQWLFGDFLCKSnRY 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  98 SLDVLLTTaSIFHLCCISLDRYYAIcCQPL---VYRNKMTPLRIALmlgGCWVIPMFiSFLPIMQGWNNIGIVDVIEKRK 174
Cdd:cd15378    78 LLHANLYS-SILFLTFISIDRYLLI-KYPFrehILQKKRSAVAISL---AIWVLVTL-ELLPILTFIGPNLKDNVTKCKD 151
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1938531436 175 FNHNSNSTFcvfmvNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAQqiqmlQRAGATSESRPQT 242
Cdd:cd15378   152 YASSGDATN-----SLIYSLFLTVTGFLIPLCVMCFFYYKIALFLKNRNR-----QLANATSFEKPLT 209
7tmA_OR51_52-like cd15917
olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of ...
23-141 9.72e-03

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 51, 52, 56, and related proteins in other mammals, sauropsids, amphibians, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 341351  Cd Length: 275  Bit Score: 37.65  E-value: 9.72e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938531436  23 LTFFAMVILmAILGNLLVMVAVCRDRQLRKiKTNYFIVSLAFADLLVSVLVMP-------FGAIE------LVQdiWFYG 89
Cdd:cd15917     5 IPFCAMYLV-ALLGNITILFVIKIESSLHE-PMYLFLAMLAATDLVLSTSTVPkmlgifwFNAREisfdacLAQ--MFFI 80
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1938531436  90 EMFCLVRTSldVLLTTAsifhlccisLDRYYAIcCQPLVYRNKMTPLRIALM 141
Cdd:cd15917    81 HSFTAMESG--VLLAMA---------FDRYVAI-CYPLRYTTILTNTVVGKI 120
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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