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Conserved domains on  [gi|31981310|ref|NP_036190|]
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B-cell receptor-associated protein 31 isoform a [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Bap31 pfam05529
Bap31/Bap29 transmembrane region; Bap31 is a polytopic integral protein of the endoplasmic ...
 1-136 1.14e-43

Bap31/Bap29 transmembrane region; Bap31 is a polytopic integral protein of the endoplasmic reticulum membrane and a substrate of caspase-8. Bap31 is cleaved within its cytosolic domain, generating pro-apoptotic p20 Bap31. This family also contains the Bap29 protein that forms a heterodimer with Bap 31.


:

Pssm-ID: 461673  Cd Length: 137  Bit Score: 143.79  E-value: 1.14e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31981310     1 MSLQWTTVATFLYAEVFAVLLLCIPFISPKRwQKVFKSRLVELVVTYGNTFFVVLIVILVLLVIDAVREILKYDDVTE-- 78
Cdd:pfam05529   1 MTLQWTLVFGFLYAEMAVFLLLVLPLPSPVR-QKIFKSRSESPLSAKFQIGFKITIIFLLILFLDAVRRVRKYSAELEsa 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 31981310    79 KVNLQNNPGAMEHFHMKLFRAQRNLYIAGFSLLLSFLLRRLVTLISQQATLLASNEAF 136
Cdd:pfam05529  80 KANAHQHPSARMEVQARKFYAQRNLYICGFTLFLSLVLRRTVTLISELATLEAKLEAL 137
Bap31_Bap29_C pfam18035
Bap31/Bap29 cytoplasmic coiled-coil domain; Bap31 is a polytopic integral protein of the ...
 192-245 3.65e-10

Bap31/Bap29 cytoplasmic coiled-coil domain; Bap31 is a polytopic integral protein of the endoplasmic reticulum membrane and a substrate of caspase-8. Bap31 is cleaved within its cytosolic domain, generating pro-apoptotic p20 Bap31. This entry represents the cytoplasmic domain which forms a heterodimeric coiled-coil with Bap29. This Bap29 and Bap31 are homologous to each other and this entry includes both proteins.


:

Pssm-ID: 465623 [Multi-domain]  Cd Length: 52  Bit Score: 54.20  E-value: 3.65e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 31981310   192 DELASTKKKLEKAENEALAMQKQSEGLTKEYDRLLEEHAKLQASVRGPsvKKEE 245
Cdd:pfam18035   1 KEIEKLKKELKKKKSDIEALKKQAEGLQREYDRLSDEHAKLQLDEGED--KKDD 52
PRK02224 super family cl32023
DNA double-strand break repair Rad50 ATPase;
134-237 4.07e-05

DNA double-strand break repair Rad50 ATPase;


The actual alignment was detected with superfamily member PRK02224:

Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 44.26  E-value: 4.07e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31981310  134 EAFKKQAESASEAAKKYMEENDQLKKGAAEDGDKLDigNTEMKLEENKSlknDLRKLKDELASTKKKLEKAENEALAMQK 213
Cdd:PRK02224 338 QAHNEEAESLREDADDLEERAEELREEAAELESELE--EAREAVEDRRE---EIEELEEEIEELRERFGDAPVDLGNAED 412

                         90       100
                 ....*....|....*....|....
gi 31981310  214 QSEGLTKEYDRLLEEHAKLQASVR 237
Cdd:PRK02224 413 FLEELREERDELREREAELEATLR 436
 
Name Accession Description Interval E-value
Bap31 pfam05529
Bap31/Bap29 transmembrane region; Bap31 is a polytopic integral protein of the endoplasmic ...
 1-136 1.14e-43

Bap31/Bap29 transmembrane region; Bap31 is a polytopic integral protein of the endoplasmic reticulum membrane and a substrate of caspase-8. Bap31 is cleaved within its cytosolic domain, generating pro-apoptotic p20 Bap31. This family also contains the Bap29 protein that forms a heterodimer with Bap 31.


Pssm-ID: 461673  Cd Length: 137  Bit Score: 143.79  E-value: 1.14e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31981310     1 MSLQWTTVATFLYAEVFAVLLLCIPFISPKRwQKVFKSRLVELVVTYGNTFFVVLIVILVLLVIDAVREILKYDDVTE-- 78
Cdd:pfam05529   1 MTLQWTLVFGFLYAEMAVFLLLVLPLPSPVR-QKIFKSRSESPLSAKFQIGFKITIIFLLILFLDAVRRVRKYSAELEsa 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 31981310    79 KVNLQNNPGAMEHFHMKLFRAQRNLYIAGFSLLLSFLLRRLVTLISQQATLLASNEAF 136
Cdd:pfam05529  80 KANAHQHPSARMEVQARKFYAQRNLYICGFTLFLSLVLRRTVTLISELATLEAKLEAL 137
Bap31_Bap29_C pfam18035
Bap31/Bap29 cytoplasmic coiled-coil domain; Bap31 is a polytopic integral protein of the ...
 192-245 3.65e-10

Bap31/Bap29 cytoplasmic coiled-coil domain; Bap31 is a polytopic integral protein of the endoplasmic reticulum membrane and a substrate of caspase-8. Bap31 is cleaved within its cytosolic domain, generating pro-apoptotic p20 Bap31. This entry represents the cytoplasmic domain which forms a heterodimeric coiled-coil with Bap29. This Bap29 and Bap31 are homologous to each other and this entry includes both proteins.


Pssm-ID: 465623 [Multi-domain]  Cd Length: 52  Bit Score: 54.20  E-value: 3.65e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 31981310   192 DELASTKKKLEKAENEALAMQKQSEGLTKEYDRLLEEHAKLQASVRGPsvKKEE 245
Cdd:pfam18035   1 KEIEKLKKELKKKKSDIEALKKQAEGLQREYDRLSDEHAKLQLDEGED--KKDD 52
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
134-237 4.07e-05

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 44.26  E-value: 4.07e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31981310  134 EAFKKQAESASEAAKKYMEENDQLKKGAAEDGDKLDigNTEMKLEENKSlknDLRKLKDELASTKKKLEKAENEALAMQK 213
Cdd:PRK02224 338 QAHNEEAESLREDADDLEERAEELREEAAELESELE--EAREAVEDRRE---EIEELEEEIEELRERFGDAPVDLGNAED 412

                         90       100
                 ....*....|....*....|....
gi 31981310  214 QSEGLTKEYDRLLEEHAKLQASVR 237
Cdd:PRK02224 413 FLEELREERDELREREAELEATLR 436
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 134-234 8.57e-03

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 36.44  E-value: 8.57e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31981310 134 EAFKKQAESASEAAKKYMEENDQLKKGAAEDGDKLDigNTEMKLEENKSLKnDLRKLKDELASTKKKLEKAENEALAMQK 213
Cdd:COG1579  41 AALEARLEAAKTELEDLEKEIKRLELEIEEVEARIK--KYEEQLGNVRNNK-EYEALQKEIESLKRRISDLEDEILELME 117

                        90       100
                ....*....|....*....|.
gi 31981310 214 QSEGLTKEYDRLLEEHAKLQA 234
Cdd:COG1579 118 RIEELEEELAELEAELAELEA 138
 
Name Accession Description Interval E-value
Bap31 pfam05529
Bap31/Bap29 transmembrane region; Bap31 is a polytopic integral protein of the endoplasmic ...
 1-136 1.14e-43

Bap31/Bap29 transmembrane region; Bap31 is a polytopic integral protein of the endoplasmic reticulum membrane and a substrate of caspase-8. Bap31 is cleaved within its cytosolic domain, generating pro-apoptotic p20 Bap31. This family also contains the Bap29 protein that forms a heterodimer with Bap 31.


Pssm-ID: 461673  Cd Length: 137  Bit Score: 143.79  E-value: 1.14e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31981310     1 MSLQWTTVATFLYAEVFAVLLLCIPFISPKRwQKVFKSRLVELVVTYGNTFFVVLIVILVLLVIDAVREILKYDDVTE-- 78
Cdd:pfam05529   1 MTLQWTLVFGFLYAEMAVFLLLVLPLPSPVR-QKIFKSRSESPLSAKFQIGFKITIIFLLILFLDAVRRVRKYSAELEsa 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 31981310    79 KVNLQNNPGAMEHFHMKLFRAQRNLYIAGFSLLLSFLLRRLVTLISQQATLLASNEAF 136
Cdd:pfam05529  80 KANAHQHPSARMEVQARKFYAQRNLYICGFTLFLSLVLRRTVTLISELATLEAKLEAL 137
Bap31_Bap29_C pfam18035
Bap31/Bap29 cytoplasmic coiled-coil domain; Bap31 is a polytopic integral protein of the ...
 192-245 3.65e-10

Bap31/Bap29 cytoplasmic coiled-coil domain; Bap31 is a polytopic integral protein of the endoplasmic reticulum membrane and a substrate of caspase-8. Bap31 is cleaved within its cytosolic domain, generating pro-apoptotic p20 Bap31. This entry represents the cytoplasmic domain which forms a heterodimeric coiled-coil with Bap29. This Bap29 and Bap31 are homologous to each other and this entry includes both proteins.


Pssm-ID: 465623 [Multi-domain]  Cd Length: 52  Bit Score: 54.20  E-value: 3.65e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 31981310   192 DELASTKKKLEKAENEALAMQKQSEGLTKEYDRLLEEHAKLQASVRGPsvKKEE 245
Cdd:pfam18035   1 KEIEKLKKELKKKKSDIEALKKQAEGLQREYDRLSDEHAKLQLDEGED--KKDD 52
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
134-237 4.07e-05

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 44.26  E-value: 4.07e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31981310  134 EAFKKQAESASEAAKKYMEENDQLKKGAAEDGDKLDigNTEMKLEENKSlknDLRKLKDELASTKKKLEKAENEALAMQK 213
Cdd:PRK02224 338 QAHNEEAESLREDADDLEERAEELREEAAELESELE--EAREAVEDRRE---EIEELEEEIEELRERFGDAPVDLGNAED 412

                         90       100
                 ....*....|....*....|....
gi 31981310  214 QSEGLTKEYDRLLEEHAKLQASVR 237
Cdd:PRK02224 413 FLEELREERDELREREAELEATLR 436
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 134-234 8.57e-03

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 36.44  E-value: 8.57e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31981310 134 EAFKKQAESASEAAKKYMEENDQLKKGAAEDGDKLDigNTEMKLEENKSLKnDLRKLKDELASTKKKLEKAENEALAMQK 213
Cdd:COG1579  41 AALEARLEAAKTELEDLEKEIKRLELEIEEVEARIK--KYEEQLGNVRNNK-EYEALQKEIESLKRRISDLEDEILELME 117

                        90       100
                ....*....|....*....|.
gi 31981310 214 QSEGLTKEYDRLLEEHAKLQA 234
Cdd:COG1579 118 RIEELEEELAELEAELAELEA 138
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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