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Conserved domains on  [gi|255522853|ref|NP_035895|]
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zinc finger protein 97 [Mus musculus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12016853)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 13-53 1.85e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 81.36  E-value: 1.85e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 255522853   13 VTYYDVLVSFTQEEWALLDPSQKSLYKDVMLETYRNLTAIG 53
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
156-541 7.19e-11

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 64.33  E-value: 7.19e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255522853 156 KPYECNQCGKAFARNSNLLDHKRIHTGEKPYKCKQCGKD--FTHHSTLHIHKRIHTREKTYKCNQ---------CMTIAH 224
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDksFSRPLELSRHLRTHHNNPSDLNSKslplsnskaSSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255522853 225 LQCHK-ITHTGEKLCEYNQcwkafAYHKTLQIHERTHT---GEKLYQCNQCAKAFP-YHRTLQIHERTHTGEKPYECNqc 299
Cdd:COG5048  112 SSSSNsNDNNLLSSHSLPP-----SSRDPQLPDLLSISnlrNNPLPGNNSSSVNTPqSNSLHPPLPANSLSKDPSSNL-- 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255522853 300 gkafaclrNLQNHKTTHTGEKPYECNQCGRAFRQYVYLQCHERIHTREKPFECNQCGKAFAHHSTLQRHKRTHtgeKPYE 379
Cdd:COG5048  185 --------SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLS---SSDS 253

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255522853 380 CNQCGKAFACPRYLQIHKRTH----------TGEKPYECNQCGKAFACYQSFQIHKRT--HTGE--KPYEC--NQCGKAF 443
Cdd:COG5048  254 SSSASESPRSSLPTASSQSSSpnesdsssekGFSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLF 333

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255522853 444 ACNRYLQIHKRTHTGERPYEC--NQCGKAFT------CRSNLQIHKRTHTgEKPYEC--NQCGKAFTQFFPLKRHEITHT 513
Cdd:COG5048  334 SRNDALKRHILLHTSISPAKEklLNSSSKFSpllnnePPQSLQQYKDLKN-DKKSETlsNSCIRNFKRDSNLSLHIITHL 412

                        410       420       430
                 ....*....|....*....|....*....|
gi 255522853 514 KEKPYECN--QCGKAFTRHSTLQIHKRTHT 541
Cdd:COG5048  413 SFRPYNCKnpPCSKSFNRHYNLIPHKKIHT 442
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 13-53 1.85e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 81.36  E-value: 1.85e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 255522853   13 VTYYDVLVSFTQEEWALLDPSQKSLYKDVMLETYRNLTAIG 53
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
13-54 7.40e-19

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 80.33  E-value: 7.40e-19
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 255522853    13 VTYYDVLVSFTQEEWALLDPSQKSLYKDVMLETYRNLTAIGY 54
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGF 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 13-50 2.59e-16

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 72.58  E-value: 2.59e-16
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 255522853  13 VTYYDVLVSFTQEEWALLDPSQKSLYKDVMLETYRNLT 50
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLV 38
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
156-541 7.19e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 64.33  E-value: 7.19e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255522853 156 KPYECNQCGKAFARNSNLLDHKRIHTGEKPYKCKQCGKD--FTHHSTLHIHKRIHTREKTYKCNQ---------CMTIAH 224
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDksFSRPLELSRHLRTHHNNPSDLNSKslplsnskaSSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255522853 225 LQCHK-ITHTGEKLCEYNQcwkafAYHKTLQIHERTHT---GEKLYQCNQCAKAFP-YHRTLQIHERTHTGEKPYECNqc 299
Cdd:COG5048  112 SSSSNsNDNNLLSSHSLPP-----SSRDPQLPDLLSISnlrNNPLPGNNSSSVNTPqSNSLHPPLPANSLSKDPSSNL-- 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255522853 300 gkafaclrNLQNHKTTHTGEKPYECNQCGRAFRQYVYLQCHERIHTREKPFECNQCGKAFAHHSTLQRHKRTHtgeKPYE 379
Cdd:COG5048  185 --------SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLS---SSDS 253

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255522853 380 CNQCGKAFACPRYLQIHKRTH----------TGEKPYECNQCGKAFACYQSFQIHKRT--HTGE--KPYEC--NQCGKAF 443
Cdd:COG5048  254 SSSASESPRSSLPTASSQSSSpnesdsssekGFSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLF 333

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255522853 444 ACNRYLQIHKRTHTGERPYEC--NQCGKAFT------CRSNLQIHKRTHTgEKPYEC--NQCGKAFTQFFPLKRHEITHT 513
Cdd:COG5048  334 SRNDALKRHILLHTSISPAKEklLNSSSKFSpllnnePPQSLQQYKDLKN-DKKSETlsNSCIRNFKRDSNLSLHIITHL 412

                        410       420       430
                 ....*....|....*....|....*....|
gi 255522853 514 KEKPYECN--QCGKAFTRHSTLQIHKRTHT 541
Cdd:COG5048  413 SFRPYNCKnpPCSKSFNRHYNLIPHKKIHT 442
zf-H2C2_2 pfam13465
Zinc-finger double domain;
365-389 1.09e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.09e-04
                          10        20
                  ....*....|....*....|....*
gi 255522853  365 LQRHKRTHTGEKPYECNQCGKAFAC 389
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 13-53 1.85e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 81.36  E-value: 1.85e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 255522853   13 VTYYDVLVSFTQEEWALLDPSQKSLYKDVMLETYRNLTAIG 53
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
13-54 7.40e-19

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 80.33  E-value: 7.40e-19
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 255522853    13 VTYYDVLVSFTQEEWALLDPSQKSLYKDVMLETYRNLTAIGY 54
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGF 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 13-50 2.59e-16

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 72.58  E-value: 2.59e-16
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 255522853  13 VTYYDVLVSFTQEEWALLDPSQKSLYKDVMLETYRNLT 50
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLV 38
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
156-541 7.19e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 64.33  E-value: 7.19e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255522853 156 KPYECNQCGKAFARNSNLLDHKRIHTGEKPYKCKQCGKD--FTHHSTLHIHKRIHTREKTYKCNQ---------CMTIAH 224
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDksFSRPLELSRHLRTHHNNPSDLNSKslplsnskaSSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255522853 225 LQCHK-ITHTGEKLCEYNQcwkafAYHKTLQIHERTHT---GEKLYQCNQCAKAFP-YHRTLQIHERTHTGEKPYECNqc 299
Cdd:COG5048  112 SSSSNsNDNNLLSSHSLPP-----SSRDPQLPDLLSISnlrNNPLPGNNSSSVNTPqSNSLHPPLPANSLSKDPSSNL-- 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255522853 300 gkafaclrNLQNHKTTHTGEKPYECNQCGRAFRQYVYLQCHERIHTREKPFECNQCGKAFAHHSTLQRHKRTHtgeKPYE 379
Cdd:COG5048  185 --------SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLS---SSDS 253

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255522853 380 CNQCGKAFACPRYLQIHKRTH----------TGEKPYECNQCGKAFACYQSFQIHKRT--HTGE--KPYEC--NQCGKAF 443
Cdd:COG5048  254 SSSASESPRSSLPTASSQSSSpnesdsssekGFSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLF 333

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255522853 444 ACNRYLQIHKRTHTGERPYEC--NQCGKAFT------CRSNLQIHKRTHTgEKPYEC--NQCGKAFTQFFPLKRHEITHT 513
Cdd:COG5048  334 SRNDALKRHILLHTSISPAKEklLNSSSKFSpllnnePPQSLQQYKDLKN-DKKSETlsNSCIRNFKRDSNLSLHIITHL 412

                        410       420       430
                 ....*....|....*....|....*....|
gi 255522853 514 KEKPYECN--QCGKAFTRHSTLQIHKRTHT 541
Cdd:COG5048  413 SFRPYNCKnpPCSKSFNRHYNLIPHKKIHT 442
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
133-525 6.13e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.17  E-value: 6.13e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255522853 133 NQCGKTFSCHNHFEIRKGTYTGEKPYECNQ--CGKAFARNSNLLDHKRIHTGEKPYKCKQCGKDfTHHSTLHiHKRIHTR 210
Cdd:COG5048   37 PNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPL-SNSKASS-SSLSSSS 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255522853 211 EKTYKCNQC--MTIAHLQCHKITHTGEKLCEYNQCwkaFAYHKTLQIHERTHTGEKLYQCNQCAKAF--PYHRTLQIHER 286
Cdd:COG5048  115 SNSNDNNLLssHSLPPSSRDPQLPDLLSISNLRNN---PLPGNNSSSVNTPQSNSLHPPLPANSLSKdpSSNLSLLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255522853 287 THTGEKPYECNQCGKAFACLRNLQNHKTTHTGEKPYECNQCGRAF------RQYVYLQCHERIHTREKPFECNQCGKAFA 360
Cdd:COG5048  192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSpksllsQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255522853 361 HHSTLQRHKRTHTG-EKPYECNQCGKAFACPRYLQIHKRT--HTGE--KPYEC--NQCGKAFACYQSFQIHKRTHTGEKP 433
Cdd:COG5048  272 SSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISP 351

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255522853 434 YEC--NQCGKAF-----ACNRYLQIHKRTHTGERPYEC--NQCGKAFTCRSNLQIHKRTHTGEKPYECN--QCGKAFTQF 502
Cdd:COG5048  352 AKEklLNSSSKFspllnNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRH 431

                        410       420
                 ....*....|....*....|...
gi 255522853 503 FPLKRHEITHTKEKPYECNQCGK 525
Cdd:COG5048  432 YNLIPHKKIHTNHAPLLCSILKS 454
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
65-497 5.59e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.47  E-value: 5.59e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255522853  65 CENSGRPTRHLQRDGPSNTGEKPFECIQYDGAFARNhhqlhkdtgsfmSYTDRQIHRRPHTEEKVYDGN-QCGKTFSCHN 143
Cdd:COG5048   39 CTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFS------------RPLELSRHLRTHHNNPSDLNSkSLPLSNSKAS 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255522853 144 HFEIRKGTYTGEKPYECNQCGKAFARNSNLLDHKRIHTGEKPYKCKQCGKDFTHH----STLHIHKRIHTREKTYKCNqc 219
Cdd:COG5048  107 SSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTpqsnSLHPPLPANSLSKDPSSNL-- 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255522853 220 mtiAHLQCHKITHTGekLCEYNQCWKAFAYHKTLQIHERT-HTGEKLYQCNQCAKAFPYHRTLQIHERTHTGEKPYECNQ 298
Cdd:COG5048  185 ---SLLISSNVSTSI--PSSSENSPLSSSYSIPSSSSDQNlENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASE 259

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255522853 299 CGKAFACLRNLQNHKTTHTGE-------KPYECNQCGRAFRQYVYLQCHER--IHTRE--KPFEC--NQCGKAFAHHSTL 365
Cdd:COG5048  260 SPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDAL 339

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255522853 366 QRHKRTHTGEKPYECnqcgkafacprYLQIHKRTHTGEKPYECNqcgkafacyQSFQIHKRTHTgEKPYEC--NQCGKAF 443
Cdd:COG5048  340 KRHILLHTSISPAKE-----------KLLNSSSKFSPLLNNEPP---------QSLQQYKDLKN-DKKSETlsNSCIRNF 398

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 255522853 444 ACNRYLQIHKRTHTGERPYECN--QCGKAFTCRSNLQIHKRTHTGEKPYECNQCGK 497
Cdd:COG5048  399 KRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS 454
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
264-542 9.95e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.24  E-value: 9.95e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255522853 264 KLYQCNQCAKAFPYHRTLQIHERTHTGEKPYECNQCGKAFACLRNLQNHKT--THTGEKPYECNQCGRAFRQYVYLQCHE 341
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHlrTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255522853 342 R-IHTREKPFECNQCGKAFAHHSTLQRHKRTHTGEKPYECNQCGKAFA----------------------CPRYLQIHKR 398
Cdd:COG5048  112 SsSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVntpqsnslhpplpanslskdpsSNLSLLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255522853 399 THTGEKPYECNQCGKAFACYQSFQIHKRTHTGEKPYECNQCGKAFACNRYLQIHKRTHTGERPYECNQCGKAFTCRSNLQ 478
Cdd:COG5048  192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 255522853 479 IHKRTHTGE-------KPYECNQCGKAFTQFFPLKRH--EITHTKE--KPYEC--NQCGKAFTRHSTLQIHKRTHTG 542
Cdd:COG5048  272 SSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHlrSVNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTS 348
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
128-312 6.14e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.92  E-value: 6.14e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255522853 128 KVYDGNQCGKTFSCHNHFE--IRKGTYTGE--KPYEC--NQCGKAFARNSNLLDHKRIHTGEKPYKCKQCgkdfthhstl 201
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTrhLRSVNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKLL---------- 357

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255522853 202 hIHKRIHTREKTYKCNQCMTIAhlqcHKITHTGEKLCEYNQCWKAFAYHKTLQIHERTHTGEKLYQCN--QCAKAFPYHR 279
Cdd:COG5048  358 -NSSSKFSPLLNNEPPQSLQQY----KDLKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHY 432

                        170       180       190
                 ....*....|....*....|....*....|...
gi 255522853 280 TLQIHERTHTGEKPYECNQCGKAFACLrNLQNH 312
Cdd:COG5048  433 NLIPHKKIHTNHAPLLCSILKSFRRDL-DLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
131-389 5.30e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.84  E-value: 5.30e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255522853 131 DGNQCGKTFSCHNHFEIRKGTYTGEKPYECNQCGKAFARNSNLLDHKRIHTGEKPYKCKQCG----KDFTHHSTLHIHKR 206
Cdd:COG5048  172 PANSLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSqlspKSLLSQSPSSLSSS 251

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255522853 207 IHTREKTYKCNQCMTIAHLQCHKITHTGE-------KLCEYNQCWKAFAYHKTLQIHERT--HTGEKLYQC----NQCAK 273
Cdd:COG5048  252 DSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGESLKPFscpySLCGK 331

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255522853 274 AFPYHRTLQIHERTHTGEKPYEC--NQCGKAF-----ACLRNLQNHKTTHTGEKPYEC--NQCGRAFRQYVYLQCHERIH 344
Cdd:COG5048  332 LFSRNDALKRHILLHTSISPAKEklLNSSSKFspllnNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITH 411

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 255522853 345 TREKP--FECNQCGKAFAHHSTLQRHKRTHTGEKPYECNQCGKAFAC 389
Cdd:COG5048  412 LSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRD 458
zf-H2C2_2 pfam13465
Zinc-finger double domain;
365-389 1.09e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.09e-04
                          10        20
                  ....*....|....*....|....*
gi 255522853  365 LQRHKRTHTGEKPYECNQCGKAFAC 389
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
476-501 2.78e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 2.78e-04
                          10        20
                  ....*....|....*....|....*.
gi 255522853  476 NLQIHKRTHTGEKPYECNQCGKAFTQ 501
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
362-441 3.14e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.53  E-value: 3.14e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255522853 362 HSTLQRHKRTHTGE----KPYECNQCGKAFACPRYLQIHKRTHTGEKPYECNQCGKAFACY--QSFQIHKRTHTGEKPYE 435
Cdd:COG5048   14 SVLSSTPKSTLKSLsnapRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSrpLELSRHLRTHHNNPSDL 93


                 ....*.
gi 255522853 436 CNQCGK 441
Cdd:COG5048   94 NSKSLP 99
zf-H2C2_2 pfam13465
Zinc-finger double domain;
172-197 4.67e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 4.67e-04
                          10        20
                  ....*....|....*....|....*.
gi 255522853  172 NLLDHKRIHTGEKPYKCKQCGKDFTH 197
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
392-417 5.63e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 5.63e-04
                          10        20
                  ....*....|....*....|....*.
gi 255522853  392 YLQIHKRTHTGEKPYECNQCGKAFAC 417
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
281-305 1.00e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.00e-03
                          10        20
                  ....*....|....*....|....*
gi 255522853  281 LQIHERTHTGEKPYECNQCGKAFAC 305
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
448-473 1.02e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.02e-03
                          10        20
                  ....*....|....*....|....*.
gi 255522853  448 YLQIHKRTHTGERPYECNQCGKAFTC 473
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
505-529 1.07e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.07e-03
                          10        20
                  ....*....|....*....|....*
gi 255522853  505 LKRHEITHTKEKPYECNQCGKAFTR 529
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
420-445 2.02e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.02e-03
                          10        20
                  ....*....|....*....|....*.
gi 255522853  420 SFQIHKRTHTGEKPYECNQCGKAFAC 445
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
308-333 3.11e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.11e-03
                          10        20
                  ....*....|....*....|....*.
gi 255522853  308 NLQNHKTTHTGEKPYECNQCGRAFRQ 333
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 458-541 3.52e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.09  E-value: 3.52e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255522853 458 GERPYECN--QCGKAFTCRSNLQIHKRThtgekpyecNQCGKAFTQFFPLKRHEITHTKEKPYECNQCGKAFTRHSTLQI 535
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHMLH---------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ....*.
gi 255522853 536 HkRTHT 541
Cdd:COG5189  417 H-RKHS 421
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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