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Conserved domains on  [gi|6755905|ref|NP_035787|]
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tubby-related protein 3 [Mus musculus]

Protein Classification

tubby family protein( domain architecture ID 11242254)

tubby (TUB) family protein similar to Mus musculus tubby protein that binds to membranes containing phosphatidylinositol 4,5-bisphosphate and functions in signal transduction from heterotrimeric G protein-coupled receptors

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Tub pfam01167
Tub family;
211-455 1.78e-138

Tub family;


:

Pssm-ID: 460094  Cd Length: 251  Bit Score: 397.72  E-value: 1.78e-138
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755905    211 YSPAPRGVTVKCKVTRDKKGMdrGLFPTYYMHLERE--ENRKiFLLAGRKRKKSKTSNYLVSTDPTDLSREGESYIGKLR 288
Cdd:pfam01167   1 KQPGPRDGTIQCFIKRDKSGM--GLTPTYHLYLELSpgDGGK-FLLAARKRRRSTTSNYLISLDADDLSRGSNGYIGKLR 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755905    289 SNLMGTKFTVYDH-----GVNPVKAQGLVEKAH---TRQELAAICYETNVLGFKGPRKMSVIIPGMNMNHERIPFRPRNE 360
Cdd:pfam01167  78 SNFLGTKFTLYDNqppynGANPSKSRSSFGSKKvspGRYELAAVSYELNVLGTRGPRRMKVIIPSIPASGQQVPIQPQSE 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755905    361 HeSLLSKWQNKSMENLIELHNKAPVWNDDTQSYVLNFHGRVTQASVKNFQIVHGNDPDYIVMQFGRVADDVFTLDYNYPL 440
Cdd:pfam01167 158 S-SLLEDFKSGRLDELLVLKNKPPRWNEQLQCYCLNFHGRVTVASVKNFQLVAPEDQDKVILQFGKVGKDMFTMDYRYPL 236

                         250
                  ....*....|....*
gi 6755905    441 CALQAFAIGLSSFDS 455
Cdd:pfam01167 237 SAFQAFAICLSSFDT 251
Tub_N pfam16322
Tubby N-terminal; Tub_N is the N-terminal region of Tubby proteins. It carries a nuclear ...
 30-151 3.25e-42

Tubby N-terminal; Tub_N is the N-terminal region of Tubby proteins. It carries a nuclear localization signal and is able to activate transcription.


:

Pssm-ID: 465092  Cd Length: 196  Bit Score: 148.42  E-value: 3.25e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755905     30 NQRALLEKKQRKKRLEPLMVQPNPEARLRRLKPRGSEEHTPLVDPQMP-RSDVILH------------------------ 84
Cdd:pfam16322   1 RQRALLEKKQRKKRQEPLMVQANPDARLRRRRPRRSEEQAPLVESYLSgNSGTIYHvqeaaprsakrsgahaalgtqggd 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6755905     85 --GIDGPAAFLKPEAQDLESKPQVLSVG----SPAPEEGTEGSadGESPEETAPKPDLQEILQKHGILSSVNY 151
Cdd:pfam16322  81 gkGIDGPAAFLTEEPQDSGSELQILSVGdsptSPPPDEELQEP--GASGEEESSKQDLGDEMQKKGISSSMNF 151
 
Name Accession Description Interval E-value
Tub pfam01167
Tub family;
211-455 1.78e-138

Tub family;


Pssm-ID: 460094  Cd Length: 251  Bit Score: 397.72  E-value: 1.78e-138
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755905    211 YSPAPRGVTVKCKVTRDKKGMdrGLFPTYYMHLERE--ENRKiFLLAGRKRKKSKTSNYLVSTDPTDLSREGESYIGKLR 288
Cdd:pfam01167   1 KQPGPRDGTIQCFIKRDKSGM--GLTPTYHLYLELSpgDGGK-FLLAARKRRRSTTSNYLISLDADDLSRGSNGYIGKLR 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755905    289 SNLMGTKFTVYDH-----GVNPVKAQGLVEKAH---TRQELAAICYETNVLGFKGPRKMSVIIPGMNMNHERIPFRPRNE 360
Cdd:pfam01167  78 SNFLGTKFTLYDNqppynGANPSKSRSSFGSKKvspGRYELAAVSYELNVLGTRGPRRMKVIIPSIPASGQQVPIQPQSE 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755905    361 HeSLLSKWQNKSMENLIELHNKAPVWNDDTQSYVLNFHGRVTQASVKNFQIVHGNDPDYIVMQFGRVADDVFTLDYNYPL 440
Cdd:pfam01167 158 S-SLLEDFKSGRLDELLVLKNKPPRWNEQLQCYCLNFHGRVTVASVKNFQLVAPEDQDKVILQFGKVGKDMFTMDYRYPL 236

                         250
                  ....*....|....*
gi 6755905    441 CALQAFAIGLSSFDS 455
Cdd:pfam01167 237 SAFQAFAICLSSFDT 251
Tub_N pfam16322
Tubby N-terminal; Tub_N is the N-terminal region of Tubby proteins. It carries a nuclear ...
 30-151 3.25e-42

Tubby N-terminal; Tub_N is the N-terminal region of Tubby proteins. It carries a nuclear localization signal and is able to activate transcription.


Pssm-ID: 465092  Cd Length: 196  Bit Score: 148.42  E-value: 3.25e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755905     30 NQRALLEKKQRKKRLEPLMVQPNPEARLRRLKPRGSEEHTPLVDPQMP-RSDVILH------------------------ 84
Cdd:pfam16322   1 RQRALLEKKQRKKRQEPLMVQANPDARLRRRRPRRSEEQAPLVESYLSgNSGTIYHvqeaaprsakrsgahaalgtqggd 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6755905     85 --GIDGPAAFLKPEAQDLESKPQVLSVG----SPAPEEGTEGSadGESPEETAPKPDLQEILQKHGILSSVNY 151
Cdd:pfam16322  81 gkGIDGPAAFLTEEPQDSGSELQILSVGdsptSPPPDEELQEP--GASGEEESSKQDLGDEMQKKGISSSMNF 151
 
Name Accession Description Interval E-value
Tub pfam01167
Tub family;
211-455 1.78e-138

Tub family;


Pssm-ID: 460094  Cd Length: 251  Bit Score: 397.72  E-value: 1.78e-138
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755905    211 YSPAPRGVTVKCKVTRDKKGMdrGLFPTYYMHLERE--ENRKiFLLAGRKRKKSKTSNYLVSTDPTDLSREGESYIGKLR 288
Cdd:pfam01167   1 KQPGPRDGTIQCFIKRDKSGM--GLTPTYHLYLELSpgDGGK-FLLAARKRRRSTTSNYLISLDADDLSRGSNGYIGKLR 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755905    289 SNLMGTKFTVYDH-----GVNPVKAQGLVEKAH---TRQELAAICYETNVLGFKGPRKMSVIIPGMNMNHERIPFRPRNE 360
Cdd:pfam01167  78 SNFLGTKFTLYDNqppynGANPSKSRSSFGSKKvspGRYELAAVSYELNVLGTRGPRRMKVIIPSIPASGQQVPIQPQSE 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755905    361 HeSLLSKWQNKSMENLIELHNKAPVWNDDTQSYVLNFHGRVTQASVKNFQIVHGNDPDYIVMQFGRVADDVFTLDYNYPL 440
Cdd:pfam01167 158 S-SLLEDFKSGRLDELLVLKNKPPRWNEQLQCYCLNFHGRVTVASVKNFQLVAPEDQDKVILQFGKVGKDMFTMDYRYPL 236

                         250
                  ....*....|....*
gi 6755905    441 CALQAFAIGLSSFDS 455
Cdd:pfam01167 237 SAFQAFAICLSSFDT 251
Tub_N pfam16322
Tubby N-terminal; Tub_N is the N-terminal region of Tubby proteins. It carries a nuclear ...
 30-151 3.25e-42

Tubby N-terminal; Tub_N is the N-terminal region of Tubby proteins. It carries a nuclear localization signal and is able to activate transcription.


Pssm-ID: 465092  Cd Length: 196  Bit Score: 148.42  E-value: 3.25e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755905     30 NQRALLEKKQRKKRLEPLMVQPNPEARLRRLKPRGSEEHTPLVDPQMP-RSDVILH------------------------ 84
Cdd:pfam16322   1 RQRALLEKKQRKKRQEPLMVQANPDARLRRRRPRRSEEQAPLVESYLSgNSGTIYHvqeaaprsakrsgahaalgtqggd 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6755905     85 --GIDGPAAFLKPEAQDLESKPQVLSVG----SPAPEEGTEGSadGESPEETAPKPDLQEILQKHGILSSVNY 151
Cdd:pfam16322  81 gkGIDGPAAFLTEEPQDSGSELQILSVGdsptSPPPDEELQEP--GASGEEESSKQDLGDEMQKKGISSSMNF 151
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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