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Conserved domains on  [gi|6754500|ref|NP_034809|]
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alpha-lactalbumin precursor [Mus musculus]

Protein Classification

lysozyme family protein; bifunctional lytic transglycosylase/C40 family peptidase( domain architecture ID 11081454)

lysozyme family protein| bifunctional lytic transglycosylase/C40 family peptidase may catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), and/or cleave peptide cross-bridges between glycan chains

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Lys pfam00062
C-type lysozyme/alpha-lactalbumin family; Alpha-lactalbumin is the regulatory subunit of ...
 21-138 6.35e-60

C-type lysozyme/alpha-lactalbumin family; Alpha-lactalbumin is the regulatory subunit of lactose synthase, changing the substrate specificity of galactosyltransferase from N-acetylglucosamine to glucose. C-type lysozymes are secreted bacteriolytic enzymes that cleave the peptidoglycan of bacterial cell walls. Structure is a multi-domain, mixed alpha and beta fold, containing four conserved disulfide bonds.


:

Pssm-ID: 395016  Cd Length: 123  Bit Score: 180.69  E-value: 6.35e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754500     21 TELTKCKVSHAIK--DIDGYQGISLLEWACVLFHTSGYDTQAVVNDNGSTEYGLFQISDRFWCKSSEFPESENICGISCD 98
Cdd:pfam00062   1 KQFTRCELARELKklGMDGYRGISLAEWVCLAFHESGYDTQAIVYNNGSTDYGIFQINDKYWCKDGKTPQSVNICGISCD 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 6754500     99 KLLDDELDDDIACAKKILAIKGIDYWKAYKPMCSEKLEQW 138
Cdd:pfam00062  81 KLLDDDITDDIMCAKKILDPQGIDAWLAWKPHCSEDLEQW 120
 
Name Accession Description Interval E-value
Lys pfam00062
C-type lysozyme/alpha-lactalbumin family; Alpha-lactalbumin is the regulatory subunit of ...
 21-138 6.35e-60

C-type lysozyme/alpha-lactalbumin family; Alpha-lactalbumin is the regulatory subunit of lactose synthase, changing the substrate specificity of galactosyltransferase from N-acetylglucosamine to glucose. C-type lysozymes are secreted bacteriolytic enzymes that cleave the peptidoglycan of bacterial cell walls. Structure is a multi-domain, mixed alpha and beta fold, containing four conserved disulfide bonds.


Pssm-ID: 395016  Cd Length: 123  Bit Score: 180.69  E-value: 6.35e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754500     21 TELTKCKVSHAIK--DIDGYQGISLLEWACVLFHTSGYDTQAVVNDNGSTEYGLFQISDRFWCKSSEFPESENICGISCD 98
Cdd:pfam00062   1 KQFTRCELARELKklGMDGYRGISLAEWVCLAFHESGYDTQAIVYNNGSTDYGIFQINDKYWCKDGKTPQSVNICGISCD 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 6754500     99 KLLDDELDDDIACAKKILAIKGIDYWKAYKPMCSEKLEQW 138
Cdd:pfam00062  81 KLLDDDITDDIMCAKKILDPQGIDAWLAWKPHCSEDLEQW 120
LYZ_LA cd16898
alpha lactalbumin; alpha-lactalbumin (lactose synthase B protein, LA) is a calcium-binding ...
 21-140 2.91e-58

alpha lactalbumin; alpha-lactalbumin (lactose synthase B protein, LA) is a calcium-binding metalloprotein that is expressed exclusively in the mammary gland during lactation. LA is the regulatory subunit of the enzyme lactose synthase. The association of LA with the catalytic component of lactose synthase, galactosyltransferase, alters the acceptor substrate specificity of this glycosyltransferase, facilitating biosynthesis of lactose.


Pssm-ID: 340384  Cd Length: 123  Bit Score: 176.86  E-value: 2.91e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754500   21 TELTKCKVSHAIKDI--DGYQGISLLEWACVLFHTSGYDTQAVVNDNGSTEYGLFQISDRFWCKSSEFPESENICGISCD 98
Cdd:cd16898   1 IIFTKCELSQILKEHglDGFNGISLPEWICVTFHTSGYDTQALVYNNGSTEYGLFQISNKGWCDDSQEPVSRNICGISCS 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 6754500   99 KLLDDELDDDIACAKKILAI-KGIDYWKAYKPMCSEKLEQWRC 140
Cdd:cd16898  81 KLLDDDITDDIACAKKILAIpKGIDYWKAHKPFCREDLDQWRC 123
LYZ1 smart00263
Alpha-lactalbumin / lysozyme C;
21-141 2.45e-52

Alpha-lactalbumin / lysozyme C;


Pssm-ID: 197612  Cd Length: 127  Bit Score: 161.69  E-value: 2.45e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754500      21 TELTKCKVSHAIKD--IDGYQGISLLEWACVLFHTSGYDTQAVVNDNG-STEYGLFQISDRFWCKSSEFPESENICGISC 97
Cdd:smart00263   1 KVFTRCELARELKRlgLDGYRGISLANWVCLAFHESGYNTQATNYNNGgSTDYGIFQINSKYWCNDGKTPGSVNACGISC 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 6754500      98 DKLLDDELDDDIACAKKILAIKGIDYWKAYKPMC-SEKLEQWR--CE 141
Cdd:smart00263  81 SKLLDDDITDDVKCAKKIVSDQGIDAWVAWKNHCqGEDLSQWIrgCG 127
 
Name Accession Description Interval E-value
Lys pfam00062
C-type lysozyme/alpha-lactalbumin family; Alpha-lactalbumin is the regulatory subunit of ...
 21-138 6.35e-60

C-type lysozyme/alpha-lactalbumin family; Alpha-lactalbumin is the regulatory subunit of lactose synthase, changing the substrate specificity of galactosyltransferase from N-acetylglucosamine to glucose. C-type lysozymes are secreted bacteriolytic enzymes that cleave the peptidoglycan of bacterial cell walls. Structure is a multi-domain, mixed alpha and beta fold, containing four conserved disulfide bonds.


Pssm-ID: 395016  Cd Length: 123  Bit Score: 180.69  E-value: 6.35e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754500     21 TELTKCKVSHAIK--DIDGYQGISLLEWACVLFHTSGYDTQAVVNDNGSTEYGLFQISDRFWCKSSEFPESENICGISCD 98
Cdd:pfam00062   1 KQFTRCELARELKklGMDGYRGISLAEWVCLAFHESGYDTQAIVYNNGSTDYGIFQINDKYWCKDGKTPQSVNICGISCD 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 6754500     99 KLLDDELDDDIACAKKILAIKGIDYWKAYKPMCSEKLEQW 138
Cdd:pfam00062  81 KLLDDDITDDIMCAKKILDPQGIDAWLAWKPHCSEDLEQW 120
LYZ_LA cd16898
alpha lactalbumin; alpha-lactalbumin (lactose synthase B protein, LA) is a calcium-binding ...
 21-140 2.91e-58

alpha lactalbumin; alpha-lactalbumin (lactose synthase B protein, LA) is a calcium-binding metalloprotein that is expressed exclusively in the mammary gland during lactation. LA is the regulatory subunit of the enzyme lactose synthase. The association of LA with the catalytic component of lactose synthase, galactosyltransferase, alters the acceptor substrate specificity of this glycosyltransferase, facilitating biosynthesis of lactose.


Pssm-ID: 340384  Cd Length: 123  Bit Score: 176.86  E-value: 2.91e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754500   21 TELTKCKVSHAIKDI--DGYQGISLLEWACVLFHTSGYDTQAVVNDNGSTEYGLFQISDRFWCKSSEFPESENICGISCD 98
Cdd:cd16898   1 IIFTKCELSQILKEHglDGFNGISLPEWICVTFHTSGYDTQALVYNNGSTEYGLFQISNKGWCDDSQEPVSRNICGISCS 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 6754500   99 KLLDDELDDDIACAKKILAI-KGIDYWKAYKPMCSEKLEQWRC 140
Cdd:cd16898  81 KLLDDDITDDIACAKKILAIpKGIDYWKAHKPFCREDLDQWRC 123
LYZ1 smart00263
Alpha-lactalbumin / lysozyme C;
21-141 2.45e-52

Alpha-lactalbumin / lysozyme C;


Pssm-ID: 197612  Cd Length: 127  Bit Score: 161.69  E-value: 2.45e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754500      21 TELTKCKVSHAIKD--IDGYQGISLLEWACVLFHTSGYDTQAVVNDNG-STEYGLFQISDRFWCKSSEFPESENICGISC 97
Cdd:smart00263   1 KVFTRCELARELKRlgLDGYRGISLANWVCLAFHESGYNTQATNYNNGgSTDYGIFQINSKYWCNDGKTPGSVNACGISC 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 6754500      98 DKLLDDELDDDIACAKKILAIKGIDYWKAYKPMC-SEKLEQWR--CE 141
Cdd:smart00263  81 SKLLDDDITDDVKCAKKIVSDQGIDAWVAWKNHCqGEDLSQWIrgCG 127
LYZ cd00119
C-type lysozyme and alpha-lactalbumin; C-type lysozyme (chicken or conventional type, 1, ...
 24-138 1.36e-45

C-type lysozyme and alpha-lactalbumin; C-type lysozyme (chicken or conventional type, 1,4-beta-N-acetylmuramidase) and alpha-lactalbumin (lactose synthase B protein, LA). They have a close evolutionary relationship and similar tertiary structure, however, functionally they are quite different. Lysozymes have primarily bacteriolytic function; hydrolysis of peptidoglycans of prokaryotic cell walls and transglycosylation. LA is a calcium-binding metalloprotein that is expressed exclusively in the mammary gland during lactation. LA is the regulatory subunit of the enzyme lactose synthase. The association of LA with the catalytic component of lactose synthase, galactosyltransferase, alters the acceptor substrate specificity of this glycosyltransferase, facilitating biosynthesis of lactose. Some lysozymes have evolved into digestive enzymes, both in mammals and invertebrates.


Pssm-ID: 340357  Cd Length: 122  Bit Score: 144.63  E-value: 1.36e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754500   24 TKCKVSHAIKDIDGYQGISLLEWACVLFHTSGYDTQAVV-NDNGSTEYGLFQISDRFWCKSSEFPESENICGISCDKLLD 102
Cdd:cd00119   4 TRCELARLLKDIGGYGGISLPNWVCLMKHESGYDTQATNeNNNGSTDYGLFQINSRYWCKDGQTPGARNICDISCSKLLT 83

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 6754500  103 DELDDDIACAKKILAIKGIDYWKAYKPMCSEKLEQW 138
Cdd:cd00119  84 DDITDAIMCAKKIVDDKGIDAWVAWKNHCQNKLRQY 119
LYZ_C cd16897
C-type lysozyme; C-type lysozyme (chicken or conventional type; 1, 4-beta-N-acetylmuramidase). ...
 23-138 1.56e-28

C-type lysozyme; C-type lysozyme (chicken or conventional type; 1, 4-beta-N-acetylmuramidase). In humans, lysozyme is found in a wide variety of tissue types and body fluids. It has bacteriolytic properties through the hydolysis of beta-1,4, glyocosidic linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan, as well as between N-acetyl-D-glucosamine residues in chitodextrins. This family also includes digestive stomach lysozyme, which allow ruminants to digest bacteria in the foregut. The mammalian enzyme is related to lysozyme found hen egg-whites and related species.


Pssm-ID: 340383  Cd Length: 126  Bit Score: 101.19  E-value: 1.56e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754500   23 LTKCKVSHAIKD--IDGYQGISLLEWACVLFHTSGYDTQAVV-NDNGSTEYGLFQISDRFWCKSSEFPeSENICGISCDK 99
Cdd:cd16897   3 FSRCELARILKRggLDGYRGYSLANWVCLAYYESGFNTRATNeNPDGSTDYGIFQINSRYWCNDGKTP-SKNLCHISCSD 81

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 6754500  100 LLDDELDDDIACAKKILA-IKGIDYWKAYKPMCSEK-LEQW 138
Cdd:cd16897  82 LLNDDITDDIKCAKKIVKdPQGMGAWVAWRLHCEGRdLSRW 122
LYZ_C_invert cd16899
C-type invertebrate lysozyme; C-type lysozyme proteins of invertebrates, including digestive ...
 46-134 1.09e-20

C-type invertebrate lysozyme; C-type lysozyme proteins of invertebrates, including digestive lysozymes 1 and 2 from Musca domestica, which aid in the use of bacteria as a food source. These lysozymes have high expression in the gut and optimal lytic activity at a lower pH. Other lysozymes in this subfamily have immunological roles. e.g. Anopheles gambiae has eight lysozymes, most of which seem to have immunological roles, those some may function as digestive enzymes in larvae. C-type lysozyme (chicken or conventional type; 1, 4-beta-N-acetylmuramidase) has bacteriolytic properties through the hydolysis of beta-1,4, glyocosidic linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan, as well as between N-acetyl-D-glucosamine residues in chitodextrins.


Pssm-ID: 381618 [Multi-domain]  Cd Length: 121  Bit Score: 81.12  E-value: 1.09e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754500   46 WACVLFHTSGYDTQAV--VNDNGSTEYGLFQISDRFWCKSSEfpESENICGISCDKLLDDELDDDIACAKKILAIKGIDY 123
Cdd:cd16899  25 WVCLAEHESSFNTTAVggPNSDGSGDYGLFQINDKYWCSPGG--GSGNGCNVKCEDLLDDDISDDVKCAKKIYKEQGFNA 102

                        90
                ....*....|.
gi 6754500  124 WKAYKPMCSEK 134
Cdd:cd16899 103 WVGWKNKCKGK 113
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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