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Conserved domains on  [gi|114326449|ref|NP_032849|]
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properdin precursor [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TSR pfam18487
Thrombospondin type 1 repeat; This is a thrombospondin type I repeat (TSR) found in properdin. ...
 24-73 2.75e-21

Thrombospondin type 1 repeat; This is a thrombospondin type I repeat (TSR) found in properdin. Properdin, also known as factor P (fP), is a glycoprotein constructed from a common pool of structure units or modules, which are homologous to the thrombospondin type 1 repeat, TSR. It is positive regulator of the complement system that stabilizes the alternative pathway C3-convertase C3bBb. Properdin also inhibits the factor H-mediated cleavage of C3b by factor I. In addition, properdin acts as a pattern recognition molecule capable of identifying and interacting with microbial surfaces, apoptotic cells, and necrotic cells. However this role of pattern recognition is controversial. Studies indicate that this domain is a TSR variants. It is present at the N-terminal of properdin and has been denoted as TSR-0. It is suggested that the TSR-0 domain of properdin which possesses only the six Cys residues and no CWR-layered motif (which is usually found in other TSR domains) may constitute a truncated TSR domain.


:

Pssm-ID: 408280  Cd Length: 50  Bit Score: 86.57  E-value: 2.75e-21
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 114326449   24 DPVLCFTQYEESSGRCKGLLGRDIRVEDCCLNAAYAFQEHDGGLCQACRS 73
Cdd:pfam18487   1 DPVLCFTQFEESSGKCKGLLGGGVSVEDCCLNPAYGFQEPGGGLCQSCRS 50
TSP_1 pfam00090
Thrombospondin type 1 domain;
136-184 2.04e-12

Thrombospondin type 1 domain;


:

Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 61.67  E-value: 2.04e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 114326449  136 SEWGPWGPCSVTCSKGTQIRQRVCDNPAPkCGGHCPGEAQQSQACDTQK 184
Cdd:pfam00090   1 SPWSPWSPCSVTCGKGIQVRQRTCKSPFP-GGEPCTGDDIETQACKMDK 48
TSP_1 pfam00090
Thrombospondin type 1 domain;
257-304 2.30e-10

Thrombospondin type 1 domain;


:

Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 55.89  E-value: 2.30e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 114326449  257 GPWSPLSPCSVTCGLGQTLEQRTCDHPAPrhGGPFCAGDATRNQMCNK 304
Cdd:pfam00090   1 SPWSPWSPCSVTCGKGIQVRQRTCKSPFP--GGEPCTGDDIETQACKM 46
TSP_1 pfam00090
Thrombospondin type 1 domain;
77-128 2.75e-07

Thrombospondin type 1 domain;


:

Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 47.03  E-value: 2.75e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 114326449   77 SAWSLWGPCSVTCSEGSQLRHRRCVGR---GGQCSENVApgtlewQLQACEDQPC 128
Cdd:pfam00090   1 SPWSPWSPCSVTCGKGIQVRQRTCKSPfpgGEPCTGDDI------ETQACKMDKC 49
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 192-251 5.41e-07

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


:

Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 46.43  E-value: 5.41e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326449   192 WASWGPWSPCSGSCLGGAQepkeTRSRSCSAPAPshQPPGKPCSGPAYEHKACSgLPPCP 251
Cdd:smart00209   1 WSEWSEWSPCSVTCGGGVQ----TRTRSCCSPPP--QNGGGPCTGEDVETRACN-EQPCP 53
 
Name Accession Description Interval E-value
TSR pfam18487
Thrombospondin type 1 repeat; This is a thrombospondin type I repeat (TSR) found in properdin. ...
 24-73 2.75e-21

Thrombospondin type 1 repeat; This is a thrombospondin type I repeat (TSR) found in properdin. Properdin, also known as factor P (fP), is a glycoprotein constructed from a common pool of structure units or modules, which are homologous to the thrombospondin type 1 repeat, TSR. It is positive regulator of the complement system that stabilizes the alternative pathway C3-convertase C3bBb. Properdin also inhibits the factor H-mediated cleavage of C3b by factor I. In addition, properdin acts as a pattern recognition molecule capable of identifying and interacting with microbial surfaces, apoptotic cells, and necrotic cells. However this role of pattern recognition is controversial. Studies indicate that this domain is a TSR variants. It is present at the N-terminal of properdin and has been denoted as TSR-0. It is suggested that the TSR-0 domain of properdin which possesses only the six Cys residues and no CWR-layered motif (which is usually found in other TSR domains) may constitute a truncated TSR domain.


Pssm-ID: 408280  Cd Length: 50  Bit Score: 86.57  E-value: 2.75e-21
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 114326449   24 DPVLCFTQYEESSGRCKGLLGRDIRVEDCCLNAAYAFQEHDGGLCQACRS 73
Cdd:pfam18487   1 DPVLCFTQFEESSGKCKGLLGGGVSVEDCCLNPAYGFQEPGGGLCQSCRS 50
TSP_1 pfam00090
Thrombospondin type 1 domain;
136-184 2.04e-12

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 61.67  E-value: 2.04e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 114326449  136 SEWGPWGPCSVTCSKGTQIRQRVCDNPAPkCGGHCPGEAQQSQACDTQK 184
Cdd:pfam00090   1 SPWSPWSPCSVTCGKGIQVRQRTCKSPFP-GGEPCTGDDIETQACKMDK 48
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 135-187 2.66e-11

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 58.37  E-value: 2.66e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 114326449   135 WSEWGPWGPCSVTCSKGTQIRQRVCDNPAPKCGG-HCPGEAQQSQACDTQKtCP 187
Cdd:smart00209   1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGgPCTGEDVETRACNEQP-CP 53
TSP_1 pfam00090
Thrombospondin type 1 domain;
257-304 2.30e-10

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 55.89  E-value: 2.30e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 114326449  257 GPWSPLSPCSVTCGLGQTLEQRTCDHPAPrhGGPFCAGDATRNQMCNK 304
Cdd:pfam00090   1 SPWSPWSPCSVTCGKGIQVRQRTCKSPFP--GGEPCTGDDIETQACKM 46
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 256-309 5.19e-08

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 49.12  E-value: 5.19e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 114326449   256 WGPWSPLSPCSVTCGLGQTLEQRTCDHPAPRHGGPFCAGDATRNQMCNKAvPCP 309
Cdd:smart00209   1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQ-PCP 53
TSP_1 pfam00090
Thrombospondin type 1 domain;
77-128 2.75e-07

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 47.03  E-value: 2.75e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 114326449   77 SAWSLWGPCSVTCSEGSQLRHRRCVGR---GGQCSENVApgtlewQLQACEDQPC 128
Cdd:pfam00090   1 SPWSPWSPCSVTCGKGIQVRQRTCKSPfpgGEPCTGDDI------ETQACKMDKC 49
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 192-251 5.41e-07

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 46.43  E-value: 5.41e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326449   192 WASWGPWSPCSGSCLGGAQepkeTRSRSCSAPAPshQPPGKPCSGPAYEHKACSgLPPCP 251
Cdd:smart00209   1 WSEWSEWSPCSVTCGGGVQ----TRTRSCCSPPP--QNGGGPCTGEDVETRACN-EQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 76-128 6.17e-06

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 43.34  E-value: 6.17e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 114326449    76 WSAWSLWGPCSVTCSEGSQLRHRRCVGRGGQCSENVAPGTLEwQLQACEDQPC 128
Cdd:smart00209   1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDV-ETRACNEQPC 52
PTZ00087 PTZ00087
thrombosponding-related protein; Provisional
 135-180 4.87e-04

thrombosponding-related protein; Provisional


Pssm-ID: 185438  Cd Length: 340  Bit Score: 42.24  E-value: 4.87e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 114326449 135 WSEWGPWGPCSVTCS--KGTQIRQRVCDNPAPKCgghCPGEAQQSQAC 180
Cdd:PTZ00087 233 YTEWGEWSNCSMECDhpDNVQIRERKCAHPSGDC---FKGDLKETRPC 277
TSP_1 pfam00090
Thrombospondin type 1 domain;
195-250 5.21e-04

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 37.78  E-value: 5.21e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 114326449  195 WGPWSPCSGSCLGGAQepkeTRSRSCSAPAPShqppGKPCSGPAYEHKACSgLPPC 250
Cdd:pfam00090   3 WSPWSPCSVTCGKGIQ----VRQRTCKSPFPG----GEPCTGDDIETQACK-MDKC 49
 
Name Accession Description Interval E-value
TSR pfam18487
Thrombospondin type 1 repeat; This is a thrombospondin type I repeat (TSR) found in properdin. ...
 24-73 2.75e-21

Thrombospondin type 1 repeat; This is a thrombospondin type I repeat (TSR) found in properdin. Properdin, also known as factor P (fP), is a glycoprotein constructed from a common pool of structure units or modules, which are homologous to the thrombospondin type 1 repeat, TSR. It is positive regulator of the complement system that stabilizes the alternative pathway C3-convertase C3bBb. Properdin also inhibits the factor H-mediated cleavage of C3b by factor I. In addition, properdin acts as a pattern recognition molecule capable of identifying and interacting with microbial surfaces, apoptotic cells, and necrotic cells. However this role of pattern recognition is controversial. Studies indicate that this domain is a TSR variants. It is present at the N-terminal of properdin and has been denoted as TSR-0. It is suggested that the TSR-0 domain of properdin which possesses only the six Cys residues and no CWR-layered motif (which is usually found in other TSR domains) may constitute a truncated TSR domain.


Pssm-ID: 408280  Cd Length: 50  Bit Score: 86.57  E-value: 2.75e-21
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 114326449   24 DPVLCFTQYEESSGRCKGLLGRDIRVEDCCLNAAYAFQEHDGGLCQACRS 73
Cdd:pfam18487   1 DPVLCFTQFEESSGKCKGLLGGGVSVEDCCLNPAYGFQEPGGGLCQSCRS 50
TSP_1 pfam00090
Thrombospondin type 1 domain;
136-184 2.04e-12

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 61.67  E-value: 2.04e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 114326449  136 SEWGPWGPCSVTCSKGTQIRQRVCDNPAPkCGGHCPGEAQQSQACDTQK 184
Cdd:pfam00090   1 SPWSPWSPCSVTCGKGIQVRQRTCKSPFP-GGEPCTGDDIETQACKMDK 48
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 135-187 2.66e-11

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 58.37  E-value: 2.66e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 114326449   135 WSEWGPWGPCSVTCSKGTQIRQRVCDNPAPKCGG-HCPGEAQQSQACDTQKtCP 187
Cdd:smart00209   1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGgPCTGEDVETRACNEQP-CP 53
TSP_1 pfam00090
Thrombospondin type 1 domain;
257-304 2.30e-10

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 55.89  E-value: 2.30e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 114326449  257 GPWSPLSPCSVTCGLGQTLEQRTCDHPAPrhGGPFCAGDATRNQMCNK 304
Cdd:pfam00090   1 SPWSPWSPCSVTCGKGIQVRQRTCKSPFP--GGEPCTGDDIETQACKM 46
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 256-309 5.19e-08

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 49.12  E-value: 5.19e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 114326449   256 WGPWSPLSPCSVTCGLGQTLEQRTCDHPAPRHGGPFCAGDATRNQMCNKAvPCP 309
Cdd:smart00209   1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQ-PCP 53
TSP_1 pfam00090
Thrombospondin type 1 domain;
77-128 2.75e-07

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 47.03  E-value: 2.75e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 114326449   77 SAWSLWGPCSVTCSEGSQLRHRRCVGR---GGQCSENVApgtlewQLQACEDQPC 128
Cdd:pfam00090   1 SPWSPWSPCSVTCGKGIQVRQRTCKSPfpgGEPCTGDDI------ETQACKMDKC 49
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 192-251 5.41e-07

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 46.43  E-value: 5.41e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326449   192 WASWGPWSPCSGSCLGGAQepkeTRSRSCSAPAPshQPPGKPCSGPAYEHKACSgLPPCP 251
Cdd:smart00209   1 WSEWSEWSPCSVTCGGGVQ----TRTRSCCSPPP--QNGGGPCTGEDVETRACN-EQPCP 53
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 136-184 3.02e-06

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 44.19  E-value: 3.02e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 114326449  136 SEWGPWGPCSVTCSKGTQIRQRVCDNPAPKCGGHCPGEaQQSQACDTQK 184
Cdd:pfam19028   4 SEWSEWSECSVTCGGGVQTRTRTVIVEPQNGGRPCPEL-LERRPCNLPP 51
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 76-128 6.17e-06

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 43.34  E-value: 6.17e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 114326449    76 WSAWSLWGPCSVTCSEGSQLRHRRCVGRGGQCSENVAPGTLEwQLQACEDQPC 128
Cdd:smart00209   1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDV-ETRACNEQPC 52
PTZ00087 PTZ00087
thrombosponding-related protein; Provisional
 135-180 4.87e-04

thrombosponding-related protein; Provisional


Pssm-ID: 185438  Cd Length: 340  Bit Score: 42.24  E-value: 4.87e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 114326449 135 WSEWGPWGPCSVTCS--KGTQIRQRVCDNPAPKCgghCPGEAQQSQAC 180
Cdd:PTZ00087 233 YTEWGEWSNCSMECDhpDNVQIRERKCAHPSGDC---FKGDLKETRPC 277
TSP_1 pfam00090
Thrombospondin type 1 domain;
195-250 5.21e-04

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 37.78  E-value: 5.21e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 114326449  195 WGPWSPCSGSCLGGAQepkeTRSRSCSAPAPShqppGKPCSGPAYEHKACSgLPPC 250
Cdd:pfam00090   3 WSPWSPCSVTCGKGIQ----VRQRTCKSPFPG----GEPCTGDDIETQACK-MDKC 49
PTZ00441 PTZ00441
sporozoite surface protein 2 (SSP2); Provisional
 138-157 1.72e-03

sporozoite surface protein 2 (SSP2); Provisional


Pssm-ID: 240420 [Multi-domain]  Cd Length: 576  Bit Score: 40.72  E-value: 1.72e-03
                         10        20
                 ....*....|....*....|
gi 114326449 138 WGPWGPCSVTCSKGTQIRQR 157
Cdd:PTZ00441 243 WDEWTPCSVTCGKGTHSRSR 262
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 77-128 3.52e-03

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 35.33  E-value: 3.52e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 114326449   77 SAWSLWGPCSVTCSEGSQLRHRRCV----GRGGQCsenvaPGTLewQLQACEDQPC 128
Cdd:pfam19028   4 SEWSEWSECSVTCGGGVQTRTRTVIvepqNGGRPC-----PELL--ERRPCNLPPC 52
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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