NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|170172526|ref|NP_032351|]
View 

alpha-L-iduronidase isoform 1 precursor [Mus musculus]

Protein Classification

6-phospho-beta-glucosidase; DMT family transporter( domain architecture ID 10472212)

6-phospho-beta-glucosidase catalyzes the conversion of 6-phospho-beta-D-glucosyl-(1,4)-D-glucose to glucose and glucose 6-phosphate| DMT (drug/metabolite transporter) family transporter is an inner membrane protein involved in the transport of one or more of a variety of substrates such as amino acids, drugs, metabolites, and sugar phosphates, among others

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Glyco_hydro_39 pfam01229
Glycosyl hydrolases family 39;
29-524 0e+00

Glycosyl hydrolases family 39;


:

Pssm-ID: 426141  Cd Length: 472  Bit Score: 732.10  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170172526   29 YLVRVDAARPLRPLLPFWRST-GFCPPLPHDQADqydlsWDQQLNLAYigavPHSGIEQVRIH-WLLDLITA-RKSPGQG 105
Cdd:pfam01229   1 VKIKVDAARDLRKLTPFWRSCvGFCPPLPALQAD-----WDQQLNLAY----PHIGFEYVRGHgWLLDDITAyRESVDQG 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170172526  106 LMYNFTHLDAFLDLLMENQLLPGFEL--------MGSPSGYF--TDFDDKQQVFEWKDLVSLLARRYIGRYGLTHVSKWN 175
Cdd:pfam01229  72 LFYNFTHIDRILDLLLENGLLPFFELgfmpkrlaSGTPTVFFweGNFTPPKQYEEWKNLVSLLARHYIGRYGLDEVSKWN 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170172526  176 FETWNEPDHHDFDNVSMTTQGFLNYYDACSEGLRIASPTLKLGGPGDSFHPLPRspmcwSLLGHCANGTnfftgevgVRL 255
Cdd:pfam01229 152 FETWNEPNLKDFDWVDMTEQEYFNLYKACAEAIKEVSPNLKVGGPADSFDPWIR-----SLLEFCYNGN--------VPL 218

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170172526  256 DYISLH---KKGAGSSIAILEQEMAV------VEQVQQLFPEFKDTPIYNDEADPlvGWSLPQPWRADVTYAALVVKVIA 326
Cdd:pfam01229 219 DFISLHaysKKGAGSSILILEEEMASeymlneVKQVRELIPEFPDLPVYNTEANP--SWSPPQPWHDDPTYAAYVVKVIA 296

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170172526  327 QHQNLLFANSSSSMRYVLLSNDNAFLSYHpypfsqrtltARFQVNNTHPphvqlLRKPVLTVMGLMALLDGEQLWAEVSk 406
Cdd:pfam01229 297 QHQDLPDANSYWTFRDVFEENDNAFLSFH----------GGFGLNNTHP-----IPKPVLTAFKLLALLDGEQLWAEVS- 360

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170172526  407 agavlDSNHTVGVLASTHHPEGSAAAWSTTVLIYTSDDTHAHPNHSIPVTLRLRGvPPGLDLVYIVLYLDNQLSSPYSAW 486
Cdd:pfam01229 361 -----DSNHTVGVIASRHDPSGALIAWNEIVLIYSSDDTTAHPDKEYPVTLRLNG-PVGFKLVYIKLMIDEDHGNPWGTW 434

                         490       500       510
                  ....*....|....*....|....*....|....*...
gi 170172526  487 QHMGQPVFPSAEQFRRMRMVEDPVAEAPRPFPARGRLT 524
Cdd:pfam01229 435 QHMGRPVFPSKEQIRRLRDAEKPKAEAPRPFPADGRLT 472
 
Name Accession Description Interval E-value
Glyco_hydro_39 pfam01229
Glycosyl hydrolases family 39;
29-524 0e+00

Glycosyl hydrolases family 39;


Pssm-ID: 426141  Cd Length: 472  Bit Score: 732.10  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170172526   29 YLVRVDAARPLRPLLPFWRST-GFCPPLPHDQADqydlsWDQQLNLAYigavPHSGIEQVRIH-WLLDLITA-RKSPGQG 105
Cdd:pfam01229   1 VKIKVDAARDLRKLTPFWRSCvGFCPPLPALQAD-----WDQQLNLAY----PHIGFEYVRGHgWLLDDITAyRESVDQG 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170172526  106 LMYNFTHLDAFLDLLMENQLLPGFEL--------MGSPSGYF--TDFDDKQQVFEWKDLVSLLARRYIGRYGLTHVSKWN 175
Cdd:pfam01229  72 LFYNFTHIDRILDLLLENGLLPFFELgfmpkrlaSGTPTVFFweGNFTPPKQYEEWKNLVSLLARHYIGRYGLDEVSKWN 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170172526  176 FETWNEPDHHDFDNVSMTTQGFLNYYDACSEGLRIASPTLKLGGPGDSFHPLPRspmcwSLLGHCANGTnfftgevgVRL 255
Cdd:pfam01229 152 FETWNEPNLKDFDWVDMTEQEYFNLYKACAEAIKEVSPNLKVGGPADSFDPWIR-----SLLEFCYNGN--------VPL 218

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170172526  256 DYISLH---KKGAGSSIAILEQEMAV------VEQVQQLFPEFKDTPIYNDEADPlvGWSLPQPWRADVTYAALVVKVIA 326
Cdd:pfam01229 219 DFISLHaysKKGAGSSILILEEEMASeymlneVKQVRELIPEFPDLPVYNTEANP--SWSPPQPWHDDPTYAAYVVKVIA 296

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170172526  327 QHQNLLFANSSSSMRYVLLSNDNAFLSYHpypfsqrtltARFQVNNTHPphvqlLRKPVLTVMGLMALLDGEQLWAEVSk 406
Cdd:pfam01229 297 QHQDLPDANSYWTFRDVFEENDNAFLSFH----------GGFGLNNTHP-----IPKPVLTAFKLLALLDGEQLWAEVS- 360

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170172526  407 agavlDSNHTVGVLASTHHPEGSAAAWSTTVLIYTSDDTHAHPNHSIPVTLRLRGvPPGLDLVYIVLYLDNQLSSPYSAW 486
Cdd:pfam01229 361 -----DSNHTVGVIASRHDPSGALIAWNEIVLIYSSDDTTAHPDKEYPVTLRLNG-PVGFKLVYIKLMIDEDHGNPWGTW 434

                         490       500       510
                  ....*....|....*....|....*....|....*...
gi 170172526  487 QHMGQPVFPSAEQFRRMRMVEDPVAEAPRPFPARGRLT 524
Cdd:pfam01229 435 QHMGRPVFPSKEQIRRLRDAEKPKAEAPRPFPADGRLT 472
XynB COG3664
Beta-xylosidase [Carbohydrate transport and metabolism];
31-537 1.41e-38

Beta-xylosidase [Carbohydrate transport and metabolism];


Pssm-ID: 442881  Cd Length: 490  Bit Score: 148.91  E-value: 1.41e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170172526  31 VRVDAARPLRPLLPFWRSTGfcpplphDQADQY----DLSWDQQLNLAYIGAVPHsgieqVRIHWLL--DLITARKSPGQ 104
Cdd:COG3664   19 ITVDLAKVAGPMKPLWAWFG-------YDEPNYtymkDGKKLLSEGAGLSPVFRY-----IRFHGLFhdDMGVYREDADG 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170172526 105 GLMYNFTHLDAFLDLLMENQLLP----GF---ELMGSPSGYF---------TDFDdkqqvfEWKDLVSLLARRYIGRYGL 168
Cdd:COG3664   87 NPVYNFTYVDKIFDFLLELGMKPfvelGFmpeALASGPQTVFwwkgnvtppKDYA------KWADLVRAFVRHLIDRYGI 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170172526 169 THVSKWNFETWNEPDHHDFdnVSMTTQGFLNYYDACSEGLRIASPTLKLGGPGDSfhplPRSPMcW--SLLGHCAngtnf 246
Cdd:COG3664  161 DEVRSWYFEVWNEPNLSGF--WKGTQEEYFKLYDYTARAVKSVDPRLRVGGPATA----GGAAA-WlpDFLEHCA----- 228

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170172526 247 ftgEVGVRLDYISLHKKGAGSSI--AILEQEMAVVEQVQQLF-----PEFKDTPIYNDEADplVGWSLPQPWRADVTYAA 319
Cdd:COG3664  229 ---KNGVPVDFVSTHAYGTDPGFdgQLSMNPDAVLRDVEKVRkliaaSAFPNLPLHITEWN--TSYTPRDPYHDTAFYAA 303

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170172526 320 LVVKVIAQHQNLlfANSsssmryvllsndnaflsyhpypFSQRTLTARF--QVNNTHPPH-------VQLLRKPVLTVMG 390
Cdd:COG3664  304 YIAKSLKRAGDL--ADS----------------------MSYWTFSDIFeeAGPPTQPFHggfgllnTNGIKKPVYHAFR 359

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170172526 391 LMALLDGEQLWAEVSKAGAVLDSNHTVGVLASTHHpegsaaawsttvliytsDDTHAHPNHsiPVTLRLRGVPPGldLVY 470
Cdd:COG3664  360 MLNRLGGERLAVGDDDAVATRDDDGRVAVLVWNYH-----------------DDDPAGPAR--TVELTLTGLPAG--KYR 418

                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 170172526 471 IVLY-LDNQLSSPYSAWQHMGQPVFPSAEQFRRMRMVEDPVAEAPRPFPARGRLTLHRKLPVPSLLLV 537
Cdd:COG3664  419 LTVYrVDEEHGNAYAAWLEMGSPQQPTREQIAELKAAAELQTSPEVVVVADGKLTLDLTLPRNSVVLI 486
 
Name Accession Description Interval E-value
Glyco_hydro_39 pfam01229
Glycosyl hydrolases family 39;
29-524 0e+00

Glycosyl hydrolases family 39;


Pssm-ID: 426141  Cd Length: 472  Bit Score: 732.10  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170172526   29 YLVRVDAARPLRPLLPFWRST-GFCPPLPHDQADqydlsWDQQLNLAYigavPHSGIEQVRIH-WLLDLITA-RKSPGQG 105
Cdd:pfam01229   1 VKIKVDAARDLRKLTPFWRSCvGFCPPLPALQAD-----WDQQLNLAY----PHIGFEYVRGHgWLLDDITAyRESVDQG 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170172526  106 LMYNFTHLDAFLDLLMENQLLPGFEL--------MGSPSGYF--TDFDDKQQVFEWKDLVSLLARRYIGRYGLTHVSKWN 175
Cdd:pfam01229  72 LFYNFTHIDRILDLLLENGLLPFFELgfmpkrlaSGTPTVFFweGNFTPPKQYEEWKNLVSLLARHYIGRYGLDEVSKWN 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170172526  176 FETWNEPDHHDFDNVSMTTQGFLNYYDACSEGLRIASPTLKLGGPGDSFHPLPRspmcwSLLGHCANGTnfftgevgVRL 255
Cdd:pfam01229 152 FETWNEPNLKDFDWVDMTEQEYFNLYKACAEAIKEVSPNLKVGGPADSFDPWIR-----SLLEFCYNGN--------VPL 218

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170172526  256 DYISLH---KKGAGSSIAILEQEMAV------VEQVQQLFPEFKDTPIYNDEADPlvGWSLPQPWRADVTYAALVVKVIA 326
Cdd:pfam01229 219 DFISLHaysKKGAGSSILILEEEMASeymlneVKQVRELIPEFPDLPVYNTEANP--SWSPPQPWHDDPTYAAYVVKVIA 296

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170172526  327 QHQNLLFANSSSSMRYVLLSNDNAFLSYHpypfsqrtltARFQVNNTHPphvqlLRKPVLTVMGLMALLDGEQLWAEVSk 406
Cdd:pfam01229 297 QHQDLPDANSYWTFRDVFEENDNAFLSFH----------GGFGLNNTHP-----IPKPVLTAFKLLALLDGEQLWAEVS- 360

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170172526  407 agavlDSNHTVGVLASTHHPEGSAAAWSTTVLIYTSDDTHAHPNHSIPVTLRLRGvPPGLDLVYIVLYLDNQLSSPYSAW 486
Cdd:pfam01229 361 -----DSNHTVGVIASRHDPSGALIAWNEIVLIYSSDDTTAHPDKEYPVTLRLNG-PVGFKLVYIKLMIDEDHGNPWGTW 434

                         490       500       510
                  ....*....|....*....|....*....|....*...
gi 170172526  487 QHMGQPVFPSAEQFRRMRMVEDPVAEAPRPFPARGRLT 524
Cdd:pfam01229 435 QHMGRPVFPSKEQIRRLRDAEKPKAEAPRPFPADGRLT 472
XynB COG3664
Beta-xylosidase [Carbohydrate transport and metabolism];
31-537 1.41e-38

Beta-xylosidase [Carbohydrate transport and metabolism];


Pssm-ID: 442881  Cd Length: 490  Bit Score: 148.91  E-value: 1.41e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170172526  31 VRVDAARPLRPLLPFWRSTGfcpplphDQADQY----DLSWDQQLNLAYIGAVPHsgieqVRIHWLL--DLITARKSPGQ 104
Cdd:COG3664   19 ITVDLAKVAGPMKPLWAWFG-------YDEPNYtymkDGKKLLSEGAGLSPVFRY-----IRFHGLFhdDMGVYREDADG 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170172526 105 GLMYNFTHLDAFLDLLMENQLLP----GF---ELMGSPSGYF---------TDFDdkqqvfEWKDLVSLLARRYIGRYGL 168
Cdd:COG3664   87 NPVYNFTYVDKIFDFLLELGMKPfvelGFmpeALASGPQTVFwwkgnvtppKDYA------KWADLVRAFVRHLIDRYGI 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170172526 169 THVSKWNFETWNEPDHHDFdnVSMTTQGFLNYYDACSEGLRIASPTLKLGGPGDSfhplPRSPMcW--SLLGHCAngtnf 246
Cdd:COG3664  161 DEVRSWYFEVWNEPNLSGF--WKGTQEEYFKLYDYTARAVKSVDPRLRVGGPATA----GGAAA-WlpDFLEHCA----- 228

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170172526 247 ftgEVGVRLDYISLHKKGAGSSI--AILEQEMAVVEQVQQLF-----PEFKDTPIYNDEADplVGWSLPQPWRADVTYAA 319
Cdd:COG3664  229 ---KNGVPVDFVSTHAYGTDPGFdgQLSMNPDAVLRDVEKVRkliaaSAFPNLPLHITEWN--TSYTPRDPYHDTAFYAA 303

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170172526 320 LVVKVIAQHQNLlfANSsssmryvllsndnaflsyhpypFSQRTLTARF--QVNNTHPPH-------VQLLRKPVLTVMG 390
Cdd:COG3664  304 YIAKSLKRAGDL--ADS----------------------MSYWTFSDIFeeAGPPTQPFHggfgllnTNGIKKPVYHAFR 359

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170172526 391 LMALLDGEQLWAEVSKAGAVLDSNHTVGVLASTHHpegsaaawsttvliytsDDTHAHPNHsiPVTLRLRGVPPGldLVY 470
Cdd:COG3664  360 MLNRLGGERLAVGDDDAVATRDDDGRVAVLVWNYH-----------------DDDPAGPAR--TVELTLTGLPAG--KYR 418

                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 170172526 471 IVLY-LDNQLSSPYSAWQHMGQPVFPSAEQFRRMRMVEDPVAEAPRPFPARGRLTLHRKLPVPSLLLV 537
Cdd:COG3664  419 LTVYrVDEEHGNAYAAWLEMGSPQQPTREQIAELKAAAELQTSPEVVVVADGKLTLDLTLPRNSVVLI 486
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH