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Conserved domains on  [gi|6324992|ref|NP_015060|]
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Kel3p [Saccharomyces cerevisiae S288C]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF4110 pfam13422
Domain of unknown function (DUF4110); This is a family that is found predominantly at the ...
 564-651 3.52e-23

Domain of unknown function (DUF4110); This is a family that is found predominantly at the C-terminus of Kelch-containing proteins. However, the exact function of this region is not known.


:

Pssm-ID: 463871  Cd Length: 95  Bit Score: 94.29  E-value: 3.52e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324992    564 PDERSWLPHPKPFETLRAFYLREGANFLTWSISNNR-----NLKGKQLKTKSFELCEDRWWERR---DQVTLEEERlEDT 635
Cdd:pfam13422   1 LGLRDSLPTPRPFESLRDFFARTSAEWQEIAIESLRdkgstSHSGKELKKEAFDLAEERYWELRpllEELRALEDE-QEE 79

                          90
                  ....*....|....*.
gi 6324992    636 GGIIErdtTTKPSKRR 651
Cdd:pfam13422  80 AGIGE---VVSRAKRK 92
NanM super family cl34543
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
79-268 7.37e-14

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


The actual alignment was detected with superfamily member COG3055:

Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 72.50  E-value: 7.37e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324992   79 RTHPLMFAnpQHNKheLFIFGGeFTDPETKLThFYNDLYSYSIKNNSWKKYVsqNAPLPRSSAAVAVhPSGIALLHGGEF 158
Cdd:COG3055  61 RHHAAAVA--QDGK--LYVFGG-FTGANPSST-PLNDVYVYDPATNTWTKLA--PMPTPRGGATALL-LDGKIYVVGGWD 131

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324992  159 SSPKQSKFYHY---SDTWlfdcverkfTKLE---------------------FGGRDSS------------PSARSGHRI 202
Cdd:COG3055 132 DGGNVAWVEVYdpaTGTW---------TQLAplptprdhlaaavlpdgkilvIGGRNGSgfsntwttlaplPTARAGHAA 202

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6324992  203 IAWKNYFILFGgfrdlgnGQTSYLNDLWCFDISTYKWTKLetNSKPDARSGHCFIPTDNSAILMGG 268
Cdd:COG3055 203 AVLGGKILVFG-------GESGFSDEVEAYDPATNTWTAL--GELPTPRHGHAAVLTDGKVYVIGG 259
Kelch_4 pfam13418
Galactose oxidase, central domain;
315-371 7.82e-04

Galactose oxidase, central domain;


:

Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 37.59  E-value: 7.82e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 6324992    315 PRVGYSFNLWKQNKSVAFGGvydlqeteESLESVFYNDLYMFHLELNKWSKLRIKPQ 371
Cdd:pfam13418   1 PRAYHTSTSIPDDTIYLFGG--------EGEDGTLLSDLWVFDLSTNEWTRLGSLPS 49
Kelch_4 pfam13418
Galactose oxidase, central domain;
250-308 7.62e-03

Galactose oxidase, central domain;


:

Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 34.90  E-value: 7.62e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324992    250 ARSGHCFIPT-DNSAILMGGYCKiiaknnknlmKGKILNDAWKLNLTPDpkkwQWEKLKN 308
Cdd:pfam13418   1 PRAYHTSTSIpDDTIYLFGGEGE----------DGTLLSDLWVFDLSTN----EWTRLGS 46
 
Name Accession Description Interval E-value
DUF4110 pfam13422
Domain of unknown function (DUF4110); This is a family that is found predominantly at the ...
 564-651 3.52e-23

Domain of unknown function (DUF4110); This is a family that is found predominantly at the C-terminus of Kelch-containing proteins. However, the exact function of this region is not known.


Pssm-ID: 463871  Cd Length: 95  Bit Score: 94.29  E-value: 3.52e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324992    564 PDERSWLPHPKPFETLRAFYLREGANFLTWSISNNR-----NLKGKQLKTKSFELCEDRWWERR---DQVTLEEERlEDT 635
Cdd:pfam13422   1 LGLRDSLPTPRPFESLRDFFARTSAEWQEIAIESLRdkgstSHSGKELKKEAFDLAEERYWELRpllEELRALEDE-QEE 79

                          90
                  ....*....|....*.
gi 6324992    636 GGIIErdtTTKPSKRR 651
Cdd:pfam13422  80 AGIGE---VVSRAKRK 92
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
79-268 7.37e-14

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 72.50  E-value: 7.37e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324992   79 RTHPLMFAnpQHNKheLFIFGGeFTDPETKLThFYNDLYSYSIKNNSWKKYVsqNAPLPRSSAAVAVhPSGIALLHGGEF 158
Cdd:COG3055  61 RHHAAAVA--QDGK--LYVFGG-FTGANPSST-PLNDVYVYDPATNTWTKLA--PMPTPRGGATALL-LDGKIYVVGGWD 131

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324992  159 SSPKQSKFYHY---SDTWlfdcverkfTKLE---------------------FGGRDSS------------PSARSGHRI 202
Cdd:COG3055 132 DGGNVAWVEVYdpaTGTW---------TQLAplptprdhlaaavlpdgkilvIGGRNGSgfsntwttlaplPTARAGHAA 202

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6324992  203 IAWKNYFILFGgfrdlgnGQTSYLNDLWCFDISTYKWTKLetNSKPDARSGHCFIPTDNSAILMGG 268
Cdd:COG3055 203 AVLGGKILVFG-------GESGFSDEVEAYDPATNTWTAL--GELPTPRHGHAAVLTDGKVYVIGG 259
Kelch_3 pfam13415
Galactose oxidase, central domain;
206-255 3.58e-07

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 47.28  E-value: 3.58e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 6324992    206 KNYFILFGGFRDLGNgqtSYLNDLWCFDISTYKWTKLETnsKPDARSGHC 255
Cdd:pfam13415   1 GDKLYIFGGLGFDGQ---TRLNDLYVYDLDTNTWTQIGD--LPPPRSGHS 45
PLN02153 PLN02153
epithiospecifier protein
 94-316 6.63e-06

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 48.83  E-value: 6.63e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324992    94 ELFIFGGEFTDPEtkltHFYNDLYSYSIKNNSWKkYVSQNAPLPR-SSAAVAVHPSGIAL-LHGGEFSSPKQSKFYHYsD 171
Cdd:PLN02153  34 KLYSFGGELKPNE----HIDKDLYVFDFNTHTWS-IAPANGDVPRiSCLGVRMVAVGTKLyIFGGRDEKREFSDFYSY-D 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324992   172 T----WLFdcverkFTKLEFGGrdsSPSARSGHRIIAWKNYFILFGGFRDLGNGQT-SYLNDLWCFDISTYKWTKL-ETN 245
Cdd:PLN02153 108 TvkneWTF------LTKLDEEG---GPEARTFHSMASDENHVYVFGGVSKGGLMKTpERFRTIEAYNIADGKWVQLpDPG 178

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6324992   246 SKPDARSGHCFIPTDNSAILMGGYCKIIAKNNKNLMKGKILNdawklnlTPDPKKWQWEKLKNFKNQPSPR 316
Cdd:PLN02153 179 ENFEKRGGAGFAVVQGKIWVVYGFATSILPGGKSDYESNAVQ-------FFDPASGKWTEVETTGAKPSAR 242
Kelch_4 pfam13418
Galactose oxidase, central domain;
315-371 7.82e-04

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 37.59  E-value: 7.82e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 6324992    315 PRVGYSFNLWKQNKSVAFGGvydlqeteESLESVFYNDLYMFHLELNKWSKLRIKPQ 371
Cdd:pfam13418   1 PRAYHTSTSIPDDTIYLFGG--------EGEDGTLLSDLWVFDLSTNEWTRLGSLPS 49
muta_rot_YjhT TIGR03547
mutatrotase, YjhT family; Members of this protein family contain multiple copies of the ...
 95-268 2.75e-03

mutatrotase, YjhT family; Members of this protein family contain multiple copies of the beta-propeller-forming Kelch repeat. All are full-length homologs to YjhT of Escherichia coli, which has been identified as a mutarotase for sialic acid. This protein improves bacterial ability to obtain host sialic acid, and thus serves as a virulence factor. Some bacteria carry what appears to be a cyclically permuted homolog of this protein.


Pssm-ID: 274641 [Multi-domain]  Cd Length: 346  Bit Score: 40.39  E-value: 2.75e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324992     95 LFIFGGEFTDPETKLTHFYNDLYSYSIKNNSWKKYvsqNAPLPRS---SAAVAVHPSGIALLHGgefsspkqskfyhySD 171
Cdd:TIGR03547  66 LYVFGGIGKANSEGSPQVFDDVYRYDPKKNSWQKL---DTRSPVGllgASGFSLHNGQAYFTGG--------------VN 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324992    172 TWLFDcveRKFTKLEFGGRDSSPSarsgHRIIAwkNYFilfggfrdlgnGQTS----YLNDLWCFDISTYKWTKLETNSk 247
Cdd:TIGR03547 129 KNIFD---GYFADLSAADKDSEPK----DKLIA--AYF-----------SQPPedyfWNKNVLSYDPSTNQWRNLGENP- 187

                         170       180
                  ....*....|....*....|.
gi 6324992    248 pdarsghcFIPTDNSAILMGG 268
Cdd:TIGR03547 188 --------FLGTAGSAIVHKG 200
Kelch_4 pfam13418
Galactose oxidase, central domain;
250-308 7.62e-03

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 34.90  E-value: 7.62e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324992    250 ARSGHCFIPT-DNSAILMGGYCKiiaknnknlmKGKILNDAWKLNLTPDpkkwQWEKLKN 308
Cdd:pfam13418   1 PRAYHTSTSIpDDTIYLFGGEGE----------DGTLLSDLWVFDLSTN----EWTRLGS 46
 
Name Accession Description Interval E-value
DUF4110 pfam13422
Domain of unknown function (DUF4110); This is a family that is found predominantly at the ...
 564-651 3.52e-23

Domain of unknown function (DUF4110); This is a family that is found predominantly at the C-terminus of Kelch-containing proteins. However, the exact function of this region is not known.


Pssm-ID: 463871  Cd Length: 95  Bit Score: 94.29  E-value: 3.52e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324992    564 PDERSWLPHPKPFETLRAFYLREGANFLTWSISNNR-----NLKGKQLKTKSFELCEDRWWERR---DQVTLEEERlEDT 635
Cdd:pfam13422   1 LGLRDSLPTPRPFESLRDFFARTSAEWQEIAIESLRdkgstSHSGKELKKEAFDLAEERYWELRpllEELRALEDE-QEE 79

                          90
                  ....*....|....*.
gi 6324992    636 GGIIErdtTTKPSKRR 651
Cdd:pfam13422  80 AGIGE---VVSRAKRK 92
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
79-268 7.37e-14

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 72.50  E-value: 7.37e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324992   79 RTHPLMFAnpQHNKheLFIFGGeFTDPETKLThFYNDLYSYSIKNNSWKKYVsqNAPLPRSSAAVAVhPSGIALLHGGEF 158
Cdd:COG3055  61 RHHAAAVA--QDGK--LYVFGG-FTGANPSST-PLNDVYVYDPATNTWTKLA--PMPTPRGGATALL-LDGKIYVVGGWD 131

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324992  159 SSPKQSKFYHY---SDTWlfdcverkfTKLE---------------------FGGRDSS------------PSARSGHRI 202
Cdd:COG3055 132 DGGNVAWVEVYdpaTGTW---------TQLAplptprdhlaaavlpdgkilvIGGRNGSgfsntwttlaplPTARAGHAA 202

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6324992  203 IAWKNYFILFGgfrdlgnGQTSYLNDLWCFDISTYKWTKLetNSKPDARSGHCFIPTDNSAILMGG 268
Cdd:COG3055 203 AVLGGKILVFG-------GESGFSDEVEAYDPATNTWTAL--GELPTPRHGHAAVLTDGKVYVIGG 259
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
95-366 7.04e-13

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 69.41  E-value: 7.04e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324992   95 LFIFGGEFTDPETklthfyNDLYSYSIKNNSWKKYVSqnAPLPRSSAAVAVHPSGIALLHGGEFSSPKQSKFyhYSDTWL 174
Cdd:COG3055  25 VYVAGGLSGGSAS------NSFEVYDPATNTWSELAP--LPGPPRHHAAAVAQDGKLYVFGGFTGANPSSTP--LNDVYV 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324992  175 FDCVERKFTKLefggrDSSPSARSGHRIIAWKNYFILFGGFRDLGngqtsYLNDLWCFDISTYKWTKLEtnSKPDARSGH 254
Cdd:COG3055  95 YDPATNTWTKL-----APMPTPRGGATALLLDGKIYVVGGWDDGG-----NVAWVEVYDPATGTWTQLA--PLPTPRDHL 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324992  255 CFIPTDNSAIL-MGGYckiiaknnknlmKGKILNDAWklnltpdpkkwqweklKNFKNQPSPRVGYSFNLWKqNKSVAFG 333
Cdd:COG3055 163 AAAVLPDGKILvIGGR------------NGSGFSNTW----------------TTLAPLPTARAGHAAAVLG-GKILVFG 213

                       250       260       270
                ....*....|....*....|....*....|...
gi 6324992  334 GvydlqeteeslESVFYNDLYMFHLELNKWSKL 366
Cdd:COG3055 214 G-----------ESGFSDEVEAYDPATNTWTAL 235
Kelch_3 pfam13415
Galactose oxidase, central domain;
206-255 3.58e-07

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 47.28  E-value: 3.58e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 6324992    206 KNYFILFGGFRDLGNgqtSYLNDLWCFDISTYKWTKLETnsKPDARSGHC 255
Cdd:pfam13415   1 GDKLYIFGGLGFDGQ---TRLNDLYVYDLDTNTWTQIGD--LPPPRSGHS 45
Kelch_3 pfam13415
Galactose oxidase, central domain;
92-146 4.62e-07

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 46.90  E-value: 4.62e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 6324992     92 KHELFIFGGEFTDPETklthFYNDLYSYSIKNNSWKKYvsQNAPLPRSSAAVAVH 146
Cdd:pfam13415   1 GDKLYIFGGLGFDGQT----RLNDLYVYDLDTNTWTQI--GDLPPPRSGHSATYI 49
Kelch_4 pfam13418
Galactose oxidase, central domain;
196-244 3.76e-06

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 44.14  E-value: 3.76e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 6324992    196 ARSGHRIIAW-KNYFILFGGFRDLGngqtSYLNDLWCFDISTYKWTKLET 244
Cdd:pfam13418   1 PRAYHTSTSIpDDTIYLFGGEGEDG----TLLSDLWVFDLSTNEWTRLGS 46
PLN02153 PLN02153
epithiospecifier protein
 94-316 6.63e-06

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 48.83  E-value: 6.63e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324992    94 ELFIFGGEFTDPEtkltHFYNDLYSYSIKNNSWKkYVSQNAPLPR-SSAAVAVHPSGIAL-LHGGEFSSPKQSKFYHYsD 171
Cdd:PLN02153  34 KLYSFGGELKPNE----HIDKDLYVFDFNTHTWS-IAPANGDVPRiSCLGVRMVAVGTKLyIFGGRDEKREFSDFYSY-D 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324992   172 T----WLFdcverkFTKLEFGGrdsSPSARSGHRIIAWKNYFILFGGFRDLGNGQT-SYLNDLWCFDISTYKWTKL-ETN 245
Cdd:PLN02153 108 TvkneWTF------LTKLDEEG---GPEARTFHSMASDENHVYVFGGVSKGGLMKTpERFRTIEAYNIADGKWVQLpDPG 178

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6324992   246 SKPDARSGHCFIPTDNSAILMGGYCKIIAKNNKNLMKGKILNdawklnlTPDPKKWQWEKLKNFKNQPSPR 316
Cdd:PLN02153 179 ENFEKRGGAGFAVVQGKIWVVYGFATSILPGGKSDYESNAVQ-------FFDPASGKWTEVETTGAKPSAR 242
PLN02193 PLN02193
nitrile-specifier protein
 95-316 9.26e-06

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 48.41  E-value: 9.26e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324992    95 LFIFGGEftDPETKlthfYNDLYSYSIKNNSWKKYVS-QNAPLPRSSAAVAVHPSGIALLhGGEFSSPKQSKFYHYsdtw 173
Cdd:PLN02193 231 LYVFGGR--DASRQ----YNGFYSFDTTTNEWKLLTPvEEGPTPRSFHSMAADEENVYVF-GGVSATARLKTLDSY---- 299

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324992   174 lfDCVERKFTKLEFGGRDSSPSARSGHRIIAWKNYFILfgGFrdlgNGqtSYLNDLWCFDISTYKWTKLET-NSKPDARS 252
Cdd:PLN02193 300 --NIVDKKWFHCSTPGDSFSIRGGAGLEVVQGKVWVVY--GF----NG--CEVDDVHYYDPVQDKWTQVETfGVRPSERS 369

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6324992   253 GHCFIPTDNSAILMGGycKIIAKNNKNLMKGKILNDAWKLnltpDPKKWQWEKLKNFKNQ---PSPR 316
Cdd:PLN02193 370 VFASAAVGKHIVIFGG--EIAMDPLAHVGPGQLTDGTFAL----DTETLQWERLDKFGEEeetPSSR 430
PLN02153 PLN02153
epithiospecifier protein
 76-253 1.07e-04

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 44.98  E-value: 1.07e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324992    76 PSCRTHPLMFANPQHnkheLFIFGGEFTDPETKLTHFYNDLYSYSIKNNSWKKYvsqnaPLP------RSSAAVAVHPSG 149
Cdd:PLN02153 125 PEARTFHSMASDENH----VYVFGGVSKGGLMKTPERFRTIEAYNIADGKWVQL-----PDPgenfekRGGAGFAVVQGK 195

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324992   150 IALLHGGEFSS-PKQSKFYHYSDTWLFDCVERKFTKLEFGGrdSSPSARS--GHRIIAwkNYFILFGG--FRD----LGN 220
Cdd:PLN02153 196 IWVVYGFATSIlPGGKSDYESNAVQFFDPASGKWTEVETTG--AKPSARSvfAHAVVG--KYIIIFGGevWPDlkghLGP 271

                        170       180       190
                 ....*....|....*....|....*....|...
gi 6324992   221 GQTSylNDLWCFDISTYKWTKLETNSKPDARSG 253
Cdd:PLN02153 272 GTLS--NEGYALDTETLVWEKLGECGEPAMPRG 302
PRK14131 PRK14131
N-acetylneuraminate epimerase;
94-271 2.59e-04

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 43.85  E-value: 2.59e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324992    94 ELFIFGGEFTDPETKLTHFYNDLYSYSIKNNSWKKYVSQNaplPRS---SAAVAVHpSGIALLHGGefsspkqskfyhyS 170
Cdd:PRK14131  86 KLYVFGGIGKTNSEGSPQVFDDVYKYDPKTNSWQKLDTRS---PVGlagHVAVSLH-NGKAYITGG-------------V 148

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324992   171 DTWLFDcveRKFTKLEFGGRDSSPSarsgHRIIawKNYFilfggfrdlgnGQTS----YLNDLWCFDISTYKWTKLETNS 246
Cdd:PRK14131 149 NKNIFD---GYFEDLAAAGKDKTPK----DKIN--DAYF-----------DKKPedyfFNKEVLSYDPSTNQWKNAGESP 208

                        170       180
                 ....*....|....*....|....*
gi 6324992   247 KPdARSGHCFIPTDNSAILMGGYCK 271
Cdd:PRK14131 209 FL-GTAGSAVVIKGNKLWLINGEIK 232
Kelch_4 pfam13418
Galactose oxidase, central domain;
89-128 2.75e-04

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 39.13  E-value: 2.75e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 6324992     89 QHNKHELFIFGGEFTDpetklTHFYNDLYSYSIKNNSWKK 128
Cdd:pfam13418   9 SIPDDTIYLFGGEGED-----GTLLSDLWVFDLSTNEWTR 43
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 196-242 6.34e-04

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 37.98  E-value: 6.34e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 6324992    196 ARSGHRIIAWKNYFILFGGFRDlgngqTSYLNDLWCFDISTYKWTKL 242
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDG-----NQSLNSVEVYDPETNTWSKL 42
Kelch_6 pfam13964
Kelch motif;
196-242 6.54e-04

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 38.09  E-value: 6.54e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 6324992    196 ARSGHRIIAWKNYFILFGGFrdlgNGQTSYLNDLWCFDISTYKWTKL 242
Cdd:pfam13964   1 PRTFHSVVSVGGYIYVFGGY----TNASPALNKLEVYNPLTKSWEEL 43
Kelch_4 pfam13418
Galactose oxidase, central domain;
315-371 7.82e-04

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 37.59  E-value: 7.82e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 6324992    315 PRVGYSFNLWKQNKSVAFGGvydlqeteESLESVFYNDLYMFHLELNKWSKLRIKPQ 371
Cdd:pfam13418   1 PRAYHTSTSIPDDTIYLFGG--------EGEDGTLLSDLWVFDLSTNEWTRLGSLPS 49
PRK14131 PRK14131
N-acetylneuraminate epimerase;
196-306 1.72e-03

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 41.15  E-value: 1.72e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324992   196 ARSGHRIIAWKNYFILFGGFRDLGN-GQTSYLNDLWCFDISTYKWTKLETNSkPDARSGHC-FIPTDNSAILMGGYCKII 273
Cdd:PRK14131  74 PREQAVAAFIDGKLYVFGGIGKTNSeGSPQVFDDVYKYDPKTNSWQKLDTRS-PVGLAGHVaVSLHNGKAYITGGVNKNI 152

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 6324992   274 ----------AKNNKNLmKGKILND-------AWKLN---LTPDPKKWQWEKL 306
Cdd:PRK14131 153 fdgyfedlaaAGKDKTP-KDKINDAyfdkkpeDYFFNkevLSYDPSTNQWKNA 204
muta_rot_YjhT TIGR03547
mutatrotase, YjhT family; Members of this protein family contain multiple copies of the ...
 95-268 2.75e-03

mutatrotase, YjhT family; Members of this protein family contain multiple copies of the beta-propeller-forming Kelch repeat. All are full-length homologs to YjhT of Escherichia coli, which has been identified as a mutarotase for sialic acid. This protein improves bacterial ability to obtain host sialic acid, and thus serves as a virulence factor. Some bacteria carry what appears to be a cyclically permuted homolog of this protein.


Pssm-ID: 274641 [Multi-domain]  Cd Length: 346  Bit Score: 40.39  E-value: 2.75e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324992     95 LFIFGGEFTDPETKLTHFYNDLYSYSIKNNSWKKYvsqNAPLPRS---SAAVAVHPSGIALLHGgefsspkqskfyhySD 171
Cdd:TIGR03547  66 LYVFGGIGKANSEGSPQVFDDVYRYDPKKNSWQKL---DTRSPVGllgASGFSLHNGQAYFTGG--------------VN 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324992    172 TWLFDcveRKFTKLEFGGRDSSPSarsgHRIIAwkNYFilfggfrdlgnGQTS----YLNDLWCFDISTYKWTKLETNSk 247
Cdd:TIGR03547 129 KNIFD---GYFADLSAADKDSEPK----DKLIA--AYF-----------SQPPedyfWNKNVLSYDPSTNQWRNLGENP- 187

                         170       180
                  ....*....|....*....|.
gi 6324992    248 pdarsghcFIPTDNSAILMGG 268
Cdd:TIGR03547 188 --------FLGTAGSAIVHKG 200
Kelch_4 pfam13418
Galactose oxidase, central domain;
250-308 7.62e-03

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 34.90  E-value: 7.62e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324992    250 ARSGHCFIPT-DNSAILMGGYCKiiaknnknlmKGKILNDAWKLNLTPDpkkwQWEKLKN 308
Cdd:pfam13418   1 PRAYHTSTSIpDDTIYLFGGEGE----------DGTLLSDLWVFDLSTN----EWTRLGS 46
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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