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Conserved domains on  [gi|4758772|ref|NP_004533|]
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NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [Homo sapiens]

Protein Classification

NDUFA3 domain-containing protein( domain architecture ID 10633185)

NDUFA3 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NADHdh_A3 pfam14987
NADH dehydrogenase 1 alpha subcomplex subunit 3; This family of proteins are accessory ...
 7-84 1.92e-52

NADH dehydrogenase 1 alpha subcomplex subunit 3; This family of proteins are accessory subunits of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I). This subunit is not believed to be catalytic.


:

Pssm-ID: 464423  Cd Length: 78  Bit Score: 158.05  E-value: 1.92e-52
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 4758772     7 AFLKNAWDKEPVLVVSFVVGGLAVILPPLSPYFKYSVMINKATPYNYPVPVRDDGNMPDVPSHPQDPQGPSLEWLKKL 84
Cdd:pfam14987  1 AFLKNAWAKEPVLVVSFVIGGLAVILPFFSPYTKYSGMINKATPYNYPVPVRDDGNMPDVPSHPQDPQGPSLEWLKNL 78
 
Name Accession Description Interval E-value
NADHdh_A3 pfam14987
NADH dehydrogenase 1 alpha subcomplex subunit 3; This family of proteins are accessory ...
 7-84 1.92e-52

NADH dehydrogenase 1 alpha subcomplex subunit 3; This family of proteins are accessory subunits of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I). This subunit is not believed to be catalytic.


Pssm-ID: 464423  Cd Length: 78  Bit Score: 158.05  E-value: 1.92e-52
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 4758772     7 AFLKNAWDKEPVLVVSFVVGGLAVILPPLSPYFKYSVMINKATPYNYPVPVRDDGNMPDVPSHPQDPQGPSLEWLKKL 84
Cdd:pfam14987  1 AFLKNAWAKEPVLVVSFVIGGLAVILPFFSPYTKYSGMINKATPYNYPVPVRDDGNMPDVPSHPQDPQGPSLEWLKNL 78
NDUFA3 cd22902
NADH dehydrogenase 1 alpha subcomplex subunit 3; NADH dehydrogenase 1 alpha subcomplex subunit ...
 5-84 1.92e-41

NADH dehydrogenase 1 alpha subcomplex subunit 3; NADH dehydrogenase 1 alpha subcomplex subunit 3 (NDUFA3) is a subunit of the of NADH:ubiquinone oxidoreductase (Respiratory complex I), which is a redox-driven proton pump that plays an important role in creating the electrochemical gradient that powers mitochondrial adenosine triphosphate synthesis. Subunit NDUFA3 is a single-pass membrane protein and is considered an accessory subunit. NDUFA3, along with subunit NDUFA5, have been shown to be necessary for assembly and/or stability of the matrix arm of human mitochondrial complex I.


Pssm-ID: 438577  Cd Length: 80  Bit Score: 130.34  E-value: 1.92e-41
                       10        20        30        40        50        60        70        80
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758772   5 VGAFLKNAWDKEPVLVVSFVVGGLAVILPPLSPYFKYSVMINKATPYNYPVPVRDDGNMPDVPSHPQDPQGPSLEWLKKL 84
Cdd:cd22902  1 VGAFLKNAWDKEPVIVVSFVIGGLAVILPYVSPYTKYKKMINKATPYNYPVPVRDDGNMPDVPSHPQDPLGPNLEWLKNL 80
 
Name Accession Description Interval E-value
NADHdh_A3 pfam14987
NADH dehydrogenase 1 alpha subcomplex subunit 3; This family of proteins are accessory ...
 7-84 1.92e-52

NADH dehydrogenase 1 alpha subcomplex subunit 3; This family of proteins are accessory subunits of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I). This subunit is not believed to be catalytic.


Pssm-ID: 464423  Cd Length: 78  Bit Score: 158.05  E-value: 1.92e-52
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 4758772     7 AFLKNAWDKEPVLVVSFVVGGLAVILPPLSPYFKYSVMINKATPYNYPVPVRDDGNMPDVPSHPQDPQGPSLEWLKKL 84
Cdd:pfam14987  1 AFLKNAWAKEPVLVVSFVIGGLAVILPFFSPYTKYSGMINKATPYNYPVPVRDDGNMPDVPSHPQDPQGPSLEWLKNL 78
NDUFA3 cd22902
NADH dehydrogenase 1 alpha subcomplex subunit 3; NADH dehydrogenase 1 alpha subcomplex subunit ...
 5-84 1.92e-41

NADH dehydrogenase 1 alpha subcomplex subunit 3; NADH dehydrogenase 1 alpha subcomplex subunit 3 (NDUFA3) is a subunit of the of NADH:ubiquinone oxidoreductase (Respiratory complex I), which is a redox-driven proton pump that plays an important role in creating the electrochemical gradient that powers mitochondrial adenosine triphosphate synthesis. Subunit NDUFA3 is a single-pass membrane protein and is considered an accessory subunit. NDUFA3, along with subunit NDUFA5, have been shown to be necessary for assembly and/or stability of the matrix arm of human mitochondrial complex I.


Pssm-ID: 438577  Cd Length: 80  Bit Score: 130.34  E-value: 1.92e-41
                       10        20        30        40        50        60        70        80
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758772   5 VGAFLKNAWDKEPVLVVSFVVGGLAVILPPLSPYFKYSVMINKATPYNYPVPVRDDGNMPDVPSHPQDPQGPSLEWLKKL 84
Cdd:cd22902  1 VGAFLKNAWDKEPVIVVSFVIGGLAVILPYVSPYTKYKKMINKATPYNYPVPVRDDGNMPDVPSHPQDPLGPNLEWLKNL 80
NDUFA3-like cd22889
NADH:Ubiquinone Oxidoreductase, NDUFA3 subunit and related proteins; This family includes the ...
 5-56 1.57e-15

NADH:Ubiquinone Oxidoreductase, NDUFA3 subunit and related proteins; This family includes the NDUFA3 subunit of NADH:ubiquinone oxidoreductase (Respiratory complex I), which is a redox-driven proton pump that plays an important role in creating the electrochemical gradient that powers mitochondrial adenosine triphosphate synthesis. Complex I catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane (NADH + ubiquinone = NAD(+) + ubiquinol). Subunit NDUFA3 is a single-pass membrane protein and is considered an accessory subunit. This family also includes N9IM, the homologous subunit from fungi, as well as some plant homologs.


Pssm-ID: 438576  Cd Length: 54  Bit Score: 63.79  E-value: 1.57e-15
                       10        20        30        40        50
               ....*....|....*....|....*....|....*....|....*....|....
gi 4758772   5 VGAFLKNAWDKEPVLVVSFVVGGLAVILPPLS--PYFKYSVMINKATPYNYPVP 56
Cdd:cd22889  1 VMAKLRMFVAQEPVLAASFLIGGVGLFLPAVVrpILDKYEASKQVKAPPLYPVP 54
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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