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Conserved domains on  [gi|40254478|ref|NP_004162|]
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excitatory amino acid transporter 2 isoform 1 [Homo sapiens]

Protein Classification

dicarboxylate/amino acid:cation symporter( domain architecture ID 10448728)

dicarboxylate/amino acid:cation symporter facilitates H+ or Na+ symport with C4-dicarboxylates, dicarboxylic amino acids (aspartate, glutamate) or other amino acids; belongs to the sodium:dicarboxylate symporter family

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SDF pfam00375
Sodium:dicarboxylate symporter family;
46-496 9.93e-122

Sodium:dicarboxylate symporter family;


:

Pssm-ID: 425646 [Multi-domain]  Cd Length: 388  Bit Score: 364.15  E-value: 9.93e-122
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254478    46 LLTLTVFGVILGAVCGGLLrlaspihPDVVMLIAFPGDILMRMLKMLILPLIISSLITGLSGL-DAKASGRLGTRAMVYY 124
Cdd:pfam00375   1 LLLQILIALVLGILIGLFF-------PELAAWLKPLGDLFIRLLKMIIVPLIFASIISGIASLgDGKKLGKLGGKTLLYF 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254478   125 MSTTIIAAVLGVILVLAIHPGNPKLKKQLGPgkKNDEVSSLDAFLDLIRNLFPENLVQACFQQiqtvtkkvlvapppdee 204
Cdd:pfam00375  74 LVTTAIAALIGLLVANVFQPGSGLALIAASL--KEAKAAEAPSLLDFILNIIPSNIFEALAEG----------------- 134

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254478   205 anatsavvsllnetvtevpeetkmvikkglefkdgmNVLGLIGFFIAFGIAMGKMGDQAKLMVDFFNILNEIVMKLVIMI 284
Cdd:pfam00375 135 ------------------------------------NVLAVIVFAILFGIALAALGEKGEPLLNFIESLQEVMMKVIGWV 178

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254478   285 MWYSPLGIACLICgKIIAIKDLEVVArQLGMYMVTVIIGLIIHGGIFLPLIYFVVTRKNPFSFFAGIFQAWITALGTASS 364
Cdd:pfam00375 179 MKLAPIGVFALIA-NTVGTYGLGILS-SLAKFLLVVYLGLAIHLLIVYPLLIKFLGKVNPFKFLKKMLPALLTAFSTASS 256

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254478   365 AGTLPVTFRCLEENLGIDKRVTRFVLPVGATINMDGTALYEAVAAIFIAQMNGVVLDGGQIVTVSLTATLASVGAASIPS 444
Cdd:pfam00375 257 AATLPVTLECAEKNLGVSESIASFVLPLGATINMDGTAIYLAVAAIFIAQAYGVDLSFGQQLTLVLTATLASIGAAGVPG 336

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|..
gi 40254478   445 AGLVTMLLILTAVGLPTEDISLLVAVDWLLDRMRTSVNVVGDSFGAGIVYHL 496
Cdd:pfam00375 337 GGLVALGLVLSALGLPLEGIALILAIDRLLDMFRTAVNVTGDAAAAVIVAKL 388
 
Name Accession Description Interval E-value
SDF pfam00375
Sodium:dicarboxylate symporter family;
46-496 9.93e-122

Sodium:dicarboxylate symporter family;


Pssm-ID: 425646 [Multi-domain]  Cd Length: 388  Bit Score: 364.15  E-value: 9.93e-122
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254478    46 LLTLTVFGVILGAVCGGLLrlaspihPDVVMLIAFPGDILMRMLKMLILPLIISSLITGLSGL-DAKASGRLGTRAMVYY 124
Cdd:pfam00375   1 LLLQILIALVLGILIGLFF-------PELAAWLKPLGDLFIRLLKMIIVPLIFASIISGIASLgDGKKLGKLGGKTLLYF 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254478   125 MSTTIIAAVLGVILVLAIHPGNPKLKKQLGPgkKNDEVSSLDAFLDLIRNLFPENLVQACFQQiqtvtkkvlvapppdee 204
Cdd:pfam00375  74 LVTTAIAALIGLLVANVFQPGSGLALIAASL--KEAKAAEAPSLLDFILNIIPSNIFEALAEG----------------- 134

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254478   205 anatsavvsllnetvtevpeetkmvikkglefkdgmNVLGLIGFFIAFGIAMGKMGDQAKLMVDFFNILNEIVMKLVIMI 284
Cdd:pfam00375 135 ------------------------------------NVLAVIVFAILFGIALAALGEKGEPLLNFIESLQEVMMKVIGWV 178

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254478   285 MWYSPLGIACLICgKIIAIKDLEVVArQLGMYMVTVIIGLIIHGGIFLPLIYFVVTRKNPFSFFAGIFQAWITALGTASS 364
Cdd:pfam00375 179 MKLAPIGVFALIA-NTVGTYGLGILS-SLAKFLLVVYLGLAIHLLIVYPLLIKFLGKVNPFKFLKKMLPALLTAFSTASS 256

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254478   365 AGTLPVTFRCLEENLGIDKRVTRFVLPVGATINMDGTALYEAVAAIFIAQMNGVVLDGGQIVTVSLTATLASVGAASIPS 444
Cdd:pfam00375 257 AATLPVTLECAEKNLGVSESIASFVLPLGATINMDGTAIYLAVAAIFIAQAYGVDLSFGQQLTLVLTATLASIGAAGVPG 336

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|..
gi 40254478   445 AGLVTMLLILTAVGLPTEDISLLVAVDWLLDRMRTSVNVVGDSFGAGIVYHL 496
Cdd:pfam00375 337 GGLVALGLVLSALGLPLEGIALILAIDRLLDMFRTAVNVTGDAAAAVIVAKL 388
GltP COG1301
Na+/H+-dicarboxylate symporter [Energy production and conversion];
43-493 3.53e-120

Na+/H+-dicarboxylate symporter [Energy production and conversion];


Pssm-ID: 440912 [Multi-domain]  Cd Length: 406  Bit Score: 360.97  E-value: 3.53e-120
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254478  43 KNLLLTLTVFGVILGAVCGGLLrlaspiHPDVVMLIAFPGDILMRMLKMLILPLIISSLITGLSGL-DAKASGRLGTRAM 121
Cdd:COG1301   2 KLSLTLQILIALVLGILLGLLL------PELVAAVLKPLGDIFINLLKMIVVPLVFFSIVVGIASLgDLKKLGRIGGKTL 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254478 122 VYYMSTTIIAAVLGVILVLAIHPGNPkLKKQLGPGKKNDEVSSLDaFLDLIRNLFPENLVQAcfqqiqtvtkkvlvappp 201
Cdd:COG1301  76 LYFLVTTTIALVIGLVVANLFQPGAG-LNLDLADAAAAEAAEAPS-LLDFLLNIIPSNIFEA------------------ 135

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254478 202 deeanatsavvsllnetvtevpeetkmvikkgleFKDGmNVLGLIGFFIAFGIAMGKMGDQAKLMVDFFNILNEIVMKLV 281
Cdd:COG1301 136 ----------------------------------FAEG-NMLQIIFFAILFGIALAALGEKGKPLLDFFESLSEVMFKIV 180

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254478 282 IMIMWYSPLGIACLIcGKIIAIKDLEVVArQLGMYMVTVIIGLIIHGGIFLPLIYFVVTRKNPFSFFAGIFQAWITALGT 361
Cdd:COG1301 181 GWVMKLAPIGVFALI-AATVAKYGLDALG-SLGKLVLTVYLALLLHLFVVLPLILRLLTGLSPLKFLRAIRPALLLAFST 258

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254478 362 ASSAGTLPVTFRCLEENLGIDKRVTRFVLPVGATINMDGTALYEAVAAIFIAQMNGVVLDGGQIVTVSLTATLASVGAAS 441
Cdd:COG1301 259 SSSEATLPVTMEKAEEKLGVSKSVASFVLPLGATINMDGTAIYQAVAALFIAQAYGIDLSLGQQLTIVLTAVLASIGAAG 338

                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|..
gi 40254478 442 IPSAGLVTMLLILTAVGLPTEDISLLVAVDWLLDRMRTSVNVVGDSFGAGIV 493
Cdd:COG1301 339 VPGAGLVMLAAVLSAVGLPLEGIALILGIDRILDMARTAVNVTGDAVATVVV 390
gltP PRK11283
glutamate/aspartate:proton symporter; Provisional
 43-487 4.14e-40

glutamate/aspartate:proton symporter; Provisional


Pssm-ID: 183075 [Multi-domain]  Cd Length: 437  Bit Score: 151.45  E-value: 4.14e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254478   43 KNLLLTLT---VFGVILGAVCGGLLRLASPIHPDVVMLIAFP-GDILMRMLKMLILPLIISSLITGLSGL-DAKASGRLG 117
Cdd:PRK11283   2 KNIKFSLAwqiLIALVLGILLGAYLHYHSDSRDWLVSNLLSPaGDIFIHLIKMIVVPIVISTLIVGIAGVgDAKQLGRIG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254478  118 TRAMVYYMSTTIIAAVLGVILVLAIHPGNPKLKKQLGP------GKKNDEVSSLD-AFLDLIRNLFPENLVQAcfqqiqt 190
Cdd:PRK11283  82 AKTIIYFEVITTVAIILGITLANVFQPGAGIDMSQLATvdiskyQSTTEEVQSHShGLMGTILSLIPTNIFAS------- 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254478  191 vtkkvlvapppdeeanatsavvsllnetvtevpeetkmvIKKGlefkdgmNVLGLIGFFIAFGIAMGKMGDQAKL-MVDF 269
Cdd:PRK11283 155 ---------------------------------------MAKG-------EMLPIIFFSVLFGLGLSSLPATHREpLVTV 188

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254478  270 FNILNEIVMKLVIMIMWYSPLGIACLICgkiiaikdlevvarqlgmymVTVIIGLIIHggiFLPLIYFVVTRKNPFSFFA 349
Cdd:PRK11283 189 FRSVSETMFKVTHMVMRYAPVGVFALIA--------------------VTVANFGFAS---LWPLAKLVLLVYFAILFFA 245

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254478  350 GI----------FQAW----------ITALGTASSAGTLPvtfRCLE--ENLGIDKRVTRFVLPVGATINMDGTALYEAV 407
Cdd:PRK11283 246 LVvlgivarlcgLSIWilirilkdelILAYSTASSETVLP---RIIEkmEAYGAPKSITSFVVPTGYSFNLDGSTLYQSI 322

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254478  408 AAIFIAQMNGVVLDGGQIVTVSLTATLASVGAASIPSAGLVTMLLILTAVGLPTEDISLLVAVDWLLDRMRTSVNVVGDS 487
Cdd:PRK11283 323 AAIFIAQLYGIDLSIWQEIILVLTLMVTSKGIAGVPGVSFVVLLATLGSVGIPLEGLAFIAGVDRILDMARTALNVVGNA 402
 
Name Accession Description Interval E-value
SDF pfam00375
Sodium:dicarboxylate symporter family;
46-496 9.93e-122

Sodium:dicarboxylate symporter family;


Pssm-ID: 425646 [Multi-domain]  Cd Length: 388  Bit Score: 364.15  E-value: 9.93e-122
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254478    46 LLTLTVFGVILGAVCGGLLrlaspihPDVVMLIAFPGDILMRMLKMLILPLIISSLITGLSGL-DAKASGRLGTRAMVYY 124
Cdd:pfam00375   1 LLLQILIALVLGILIGLFF-------PELAAWLKPLGDLFIRLLKMIIVPLIFASIISGIASLgDGKKLGKLGGKTLLYF 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254478   125 MSTTIIAAVLGVILVLAIHPGNPKLKKQLGPgkKNDEVSSLDAFLDLIRNLFPENLVQACFQQiqtvtkkvlvapppdee 204
Cdd:pfam00375  74 LVTTAIAALIGLLVANVFQPGSGLALIAASL--KEAKAAEAPSLLDFILNIIPSNIFEALAEG----------------- 134

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254478   205 anatsavvsllnetvtevpeetkmvikkglefkdgmNVLGLIGFFIAFGIAMGKMGDQAKLMVDFFNILNEIVMKLVIMI 284
Cdd:pfam00375 135 ------------------------------------NVLAVIVFAILFGIALAALGEKGEPLLNFIESLQEVMMKVIGWV 178

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254478   285 MWYSPLGIACLICgKIIAIKDLEVVArQLGMYMVTVIIGLIIHGGIFLPLIYFVVTRKNPFSFFAGIFQAWITALGTASS 364
Cdd:pfam00375 179 MKLAPIGVFALIA-NTVGTYGLGILS-SLAKFLLVVYLGLAIHLLIVYPLLIKFLGKVNPFKFLKKMLPALLTAFSTASS 256

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254478   365 AGTLPVTFRCLEENLGIDKRVTRFVLPVGATINMDGTALYEAVAAIFIAQMNGVVLDGGQIVTVSLTATLASVGAASIPS 444
Cdd:pfam00375 257 AATLPVTLECAEKNLGVSESIASFVLPLGATINMDGTAIYLAVAAIFIAQAYGVDLSFGQQLTLVLTATLASIGAAGVPG 336

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|..
gi 40254478   445 AGLVTMLLILTAVGLPTEDISLLVAVDWLLDRMRTSVNVVGDSFGAGIVYHL 496
Cdd:pfam00375 337 GGLVALGLVLSALGLPLEGIALILAIDRLLDMFRTAVNVTGDAAAAVIVAKL 388
GltP COG1301
Na+/H+-dicarboxylate symporter [Energy production and conversion];
43-493 3.53e-120

Na+/H+-dicarboxylate symporter [Energy production and conversion];


Pssm-ID: 440912 [Multi-domain]  Cd Length: 406  Bit Score: 360.97  E-value: 3.53e-120
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254478  43 KNLLLTLTVFGVILGAVCGGLLrlaspiHPDVVMLIAFPGDILMRMLKMLILPLIISSLITGLSGL-DAKASGRLGTRAM 121
Cdd:COG1301   2 KLSLTLQILIALVLGILLGLLL------PELVAAVLKPLGDIFINLLKMIVVPLVFFSIVVGIASLgDLKKLGRIGGKTL 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254478 122 VYYMSTTIIAAVLGVILVLAIHPGNPkLKKQLGPGKKNDEVSSLDaFLDLIRNLFPENLVQAcfqqiqtvtkkvlvappp 201
Cdd:COG1301  76 LYFLVTTTIALVIGLVVANLFQPGAG-LNLDLADAAAAEAAEAPS-LLDFLLNIIPSNIFEA------------------ 135

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254478 202 deeanatsavvsllnetvtevpeetkmvikkgleFKDGmNVLGLIGFFIAFGIAMGKMGDQAKLMVDFFNILNEIVMKLV 281
Cdd:COG1301 136 ----------------------------------FAEG-NMLQIIFFAILFGIALAALGEKGKPLLDFFESLSEVMFKIV 180

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254478 282 IMIMWYSPLGIACLIcGKIIAIKDLEVVArQLGMYMVTVIIGLIIHGGIFLPLIYFVVTRKNPFSFFAGIFQAWITALGT 361
Cdd:COG1301 181 GWVMKLAPIGVFALI-AATVAKYGLDALG-SLGKLVLTVYLALLLHLFVVLPLILRLLTGLSPLKFLRAIRPALLLAFST 258

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254478 362 ASSAGTLPVTFRCLEENLGIDKRVTRFVLPVGATINMDGTALYEAVAAIFIAQMNGVVLDGGQIVTVSLTATLASVGAAS 441
Cdd:COG1301 259 SSSEATLPVTMEKAEEKLGVSKSVASFVLPLGATINMDGTAIYQAVAALFIAQAYGIDLSLGQQLTIVLTAVLASIGAAG 338

                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|..
gi 40254478 442 IPSAGLVTMLLILTAVGLPTEDISLLVAVDWLLDRMRTSVNVVGDSFGAGIV 493
Cdd:COG1301 339 VPGAGLVMLAAVLSAVGLPLEGIALILGIDRILDMARTAVNVTGDAVATVVV 390
gltP PRK11283
glutamate/aspartate:proton symporter; Provisional
 43-487 4.14e-40

glutamate/aspartate:proton symporter; Provisional


Pssm-ID: 183075 [Multi-domain]  Cd Length: 437  Bit Score: 151.45  E-value: 4.14e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254478   43 KNLLLTLT---VFGVILGAVCGGLLRLASPIHPDVVMLIAFP-GDILMRMLKMLILPLIISSLITGLSGL-DAKASGRLG 117
Cdd:PRK11283   2 KNIKFSLAwqiLIALVLGILLGAYLHYHSDSRDWLVSNLLSPaGDIFIHLIKMIVVPIVISTLIVGIAGVgDAKQLGRIG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254478  118 TRAMVYYMSTTIIAAVLGVILVLAIHPGNPKLKKQLGP------GKKNDEVSSLD-AFLDLIRNLFPENLVQAcfqqiqt 190
Cdd:PRK11283  82 AKTIIYFEVITTVAIILGITLANVFQPGAGIDMSQLATvdiskyQSTTEEVQSHShGLMGTILSLIPTNIFAS------- 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254478  191 vtkkvlvapppdeeanatsavvsllnetvtevpeetkmvIKKGlefkdgmNVLGLIGFFIAFGIAMGKMGDQAKL-MVDF 269
Cdd:PRK11283 155 ---------------------------------------MAKG-------EMLPIIFFSVLFGLGLSSLPATHREpLVTV 188

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254478  270 FNILNEIVMKLVIMIMWYSPLGIACLICgkiiaikdlevvarqlgmymVTVIIGLIIHggiFLPLIYFVVTRKNPFSFFA 349
Cdd:PRK11283 189 FRSVSETMFKVTHMVMRYAPVGVFALIA--------------------VTVANFGFAS---LWPLAKLVLLVYFAILFFA 245

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254478  350 GI----------FQAW----------ITALGTASSAGTLPvtfRCLE--ENLGIDKRVTRFVLPVGATINMDGTALYEAV 407
Cdd:PRK11283 246 LVvlgivarlcgLSIWilirilkdelILAYSTASSETVLP---RIIEkmEAYGAPKSITSFVVPTGYSFNLDGSTLYQSI 322

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254478  408 AAIFIAQMNGVVLDGGQIVTVSLTATLASVGAASIPSAGLVTMLLILTAVGLPTEDISLLVAVDWLLDRMRTSVNVVGDS 487
Cdd:PRK11283 323 AAIFIAQLYGIDLSIWQEIILVLTLMVTSKGIAGVPGVSFVVLLATLGSVGIPLEGLAFIAGVDRILDMARTALNVVGNA 402
PRK01663 PRK01663
C4-dicarboxylate transporter DctA; Reviewed
 52-503 6.31e-39

C4-dicarboxylate transporter DctA; Reviewed


Pssm-ID: 234968 [Multi-domain]  Cd Length: 428  Bit Score: 147.74  E-value: 6.31e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254478   52 FGVILGAVCGGLLRLaspIHPDVVMLIAFPGDILMRMLKMLILPLIISSLITGLSGL-DAKASGRLGTRAMVYYMSTTII 130
Cdd:PRK01663  11 FQVLVAIIIGILLGH---FYPELGAQMKPLGDGFIKLIKMIIAPIIFCTVVTGIAGMgDMKKVGRVGGKALLYFEIVSTI 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254478  131 AAVLGVILVLAIHPGNpklkkqlgpgKKNDEVSSLDA--------------FLDLIRNLFPENLVQAcfqqiqtvtkkvl 196
Cdd:PRK01663  88 ALIIGLIVVNVVQPGA----------GMNIDPATLDAkavaqyaaqaheqgTVDFLMDIIPTTVVGA------------- 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254478  197 vapppdeeanatsavvsllnetvtevpeetkmvikkgleFKDGmNVLGLIGFFIAFGIAMGKMGDQAKLMVDFFNILNEI 276
Cdd:PRK01663 145 ---------------------------------------FASG-DILQVLLFAVLFGFALARLGEKGKPVFDFIESLSHV 184

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254478  277 VMKLVIMIMWYSPLG----IACLIcGKIiAIKDLevvaRQLGMYMVTViigliihggiFLPLIYFV------VTRKNPFS 346
Cdd:PRK01663 185 LFGIVNMIMKLAPIGafgaMAFTI-GKY-GVGSL----VQLGQLIGCF----------YITCILFVfvvlgaIARLTGFS 248

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254478  347 FFAgiFQAWITA-----LGTASSAGTLPVTFRCLEeNLGIDKRVTRFVLPVGATINMDGTALYEAVAAIFIAQMNGVVLD 421
Cdd:PRK01663 249 IFK--FIRYIKEellivLGTSSSESALPRMMEKME-KLGCKKSVVGLVIPTGYSFNLDGTSIYLTMAAVFIAQATNTPLS 325

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254478  422 GGQIVTVSLTATLASVGAASIPSAGLVTMLLILTAVG-LPTEDISLLVAVDWLLDRMRTSVNVVGDSFgAGIVYHLSKSE 500
Cdd:PRK01663 326 IGHQITLLAVLLLTSKGAAGVTGSGFIVLAATLSAVPhIPVAGLALILGIDRFMSEARALTNLIGNGV-ATVVVAKWEKE 404


                 ...
gi 40254478  501 LDT 503
Cdd:PRK01663 405 LDR 407
PRK13027 PRK13027
C4-dicarboxylate transporter DctA; Reviewed
 51-486 4.38e-35

C4-dicarboxylate transporter DctA; Reviewed


Pssm-ID: 183850 [Multi-domain]  Cd Length: 421  Bit Score: 136.72  E-value: 4.38e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254478   51 VFGVILGAVCGGLLrlaspihPDVVMLIAFPGDILMRMLKMLILPLIISSLITGLSGL-DAKASGRLGTRAMVYYMSTTI 129
Cdd:PRK13027  13 VIALVLGVALGAFF-------PHFAESLKPLGDGFIKLIKMLIGPIVFCVVVSGIAGAgDLKKVGRVGLKAVIYFEVMTT 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254478  130 IAAVLGVILVLAIHPG---NPKLKkQLGPGKKNDEVS---SLDAFLDLIRNLFPENLVQAcfqqiqtvtkkvlvapppde 203
Cdd:PRK13027  86 IALVIGLVLAYLTGPGvgmNIDLR-SLDAASLAGYAKnaqSLKGTAGFLLKLIPTTAVDA-------------------- 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254478  204 eanatsavvsllnetvtevpeetkmvikkgleFKDGmNVLGLIGFFIAFGIAMGKMGDQAKLMVDFFNILNEIVMKLVIM 283
Cdd:PRK13027 145 --------------------------------FAKG-DILQVLLFSVLFGSALSLLGERAKRVNRLIDELSHVLFRIMGF 191

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254478  284 IMWYSPLGIACLIC---GKIiAIKDLevvaRQLGMYMVTVIIGLIIhggiFLPLIYFVVTRKNPFSFFAGIF---QAWIT 357
Cdd:PRK13027 192 IIKLAPLGVLGAIAfttGKY-GVGSL----KQLGMLVAVFYLTCFV----FVVVVLGAVMRLAGFSVFKLIRylrEELLI 262

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254478  358 ALGTASSAGTLPVTFRCLEeNLGIDKRVTRFVLPVGATINMDGTALYEAVAAIFIAQMNGVVLDGGQIVTVSLTATLASV 437
Cdd:PRK13027 263 VLGTASSDAVLPQVMRKLE-HMGIKDSTVGLVIPTGYSFNLDGFSIYLTLAAVFIAQATNTPLSMHDLITILLVSLVTSK 341

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|
gi 40254478  438 GAASIPSAGLVTMLLILTAVG-LPTEDISLLVAVDWLLDRMRTSVNVVGD 486
Cdd:PRK13027 342 GAHGIPGSAIVILAATLSAIPaIPVLGLVLILPVDWFMGIARALTNLIGN 391
TcyP COG1823
L-cystine transporter TcyP, sodium:dicarboxylate symporter family [Amino acid transport and ...
 43-493 2.60e-23

L-cystine transporter TcyP, sodium:dicarboxylate symporter family [Amino acid transport and metabolism];


Pssm-ID: 441428  Cd Length: 463  Bit Score: 102.98  E-value: 2.60e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254478  43 KNLLLTLTVF-GVILGAVCGGLLRLA----SPIHPDVVMLIAFPGDILMRMLKMLILPLIISSLITGLSGL-DAKASGRL 116
Cdd:COG1823  26 KHVSFSKRVFtGLGLGILFGLILQLIygagSPVIKQSIDWFNIVGNGYVRLLQMIVMPLVFVSILSAITKLkNASSLGKI 105

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254478 117 GTRAMVYYMSTTIIAAVLGVILVLAIHpgnpklkkqlgpgkkndevssLDAfldlirnlfpENLVQAcfqqiqtvtkkvl 196
Cdd:COG1823 106 SGLIIGILLGTTAIAALVGILVALLFG---------------------LTA----------EGLTQG------------- 141

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254478 197 vappPDEEANATSavvslLNETVTEVPEETkmVIKKGLE------FKD--GMNVLGLIG--FFIAF-GIA----MGKMGD 261
Cdd:COG1823 142 ----AAETARGEA-----LEERLGEVEDLS--LPQQILSfiptnpFADltGARPTSTIAvvIFAAFlGIAalglRRKKPE 210

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254478 262 QAKLMVDFFNILNEIVMKLVIMIMWYSPLGIACLICgKIIAIKDLEVVArQLGMYmvtVIIGLIIHGGIFL-PLIYFVVT 340
Cdd:COG1823 211 QAETFLKGIDALQAIVMRLVRLVLRLTPYGVLALMT-KVVATSDFADIL-NLGKF---VVASYVALIIMFIvHLLLLALA 285

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254478 341 RKNPFSFFAGIFQAWITALGTASSAGTLPVTFRCLEENLGIDKRVTRFVLPVGATINMDGTA-LYEAVAAIFIAQMNGV- 418
Cdd:COG1823 286 GLNPLTYFKKVWPVLTFAFTSRSSAGTIPLNIETQTKRLGVPEGIANFAASFGATIGQNGCAgIYPAMLAVMIAPTVGIn 365

                       410       420       430       440       450       460       470
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 40254478 419 VLDGGQIVTVSLTATLASVGAASIPSAGLVTMLLILTAVGLPTEDISLLVAVDWLLDRMRTSVNvVGDSFGAGIV 493
Cdd:COG1823 366 PLDPSFILTLIAVVTISSFGVAGVGGGATFAALIVLSAMGLPVALAGLLISIEPLIDMGRTALN-VSGSMTAGTV 439
PRK14695 PRK14695
serine/threonine transporter SstT; Provisional
 241-487 3.63e-13

serine/threonine transporter SstT; Provisional


Pssm-ID: 173158  Cd Length: 319  Bit Score: 70.85  E-value: 3.63e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254478  241 NVLGLIGFFIAFGIAMGKMGDQAKlmvDFFNILNEIVMKLVIMIMWYSPLGIACLICgKIIAIKDLEVVArQLGMYMVTV 320
Cdd:PRK14695  60 NYIGILSWAVIFGIAMREASKNSK---ELLKTIADVTSKIVEWIINLAPFGILGLVF-KTISDKGVGSLA-NYGILLVLL 134

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254478  321 IIGLIIHGGIFLPLIYFVVTRKNPFSFFAGIFQ-AWITALGTASSAGTLPVTFRcLEENLGIDKRVTRFVLPVGATINMD 399
Cdd:PRK14695 135 VTTMLFVAPVVNPLIAFFFMRRNPYPLVWNCLRvSGVTAFFTRSSATNIPVNMK-LCHDLGLNPDTYSVSIPLGSTINMA 213

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254478  400 GTALYEAVAAIFIAQMNGVVLDGGQIVTVSLTATLASVGAASIPSAGLVTMLLILTAVGLPTEDISLLVAVDWLLDRMRT 479
Cdd:PRK14695 214 GVAITINLLTLVTVNTLGIPVDFATAFVLSVVAAISACGASGIAGGSLLLIPVACSLFGISNDIAIQIVGVGFVIGVIQD 293


                 ....*...
gi 40254478  480 SVNVVGDS 487
Cdd:PRK14695 294 SCETALNS 301
PRK13628 PRK13628
serine/threonine transporter SstT; Provisional
 241-459 2.75e-11

serine/threonine transporter SstT; Provisional


Pssm-ID: 184190 [Multi-domain]  Cd Length: 402  Bit Score: 65.66  E-value: 2.75e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254478  241 NVLGLIGFFIAFGIAMGKMGDQAKlmvDFFNILNEIVMKLVIMIMWYSPLGIACLICGkIIAIKDLEVVARQLGMYMVTV 320
Cdd:PRK13628 146 NYIGILAWAIGLGLALRHASDTTK---NVVNDLSEAVSQIVKWVIRFAPIGIFGLVAS-TLAETGFSALAGYAQLLAVLV 221

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254478  321 IIGLIIHGGiFLPLIYFVVTRKNPFSF-FAGIFQAWITALGTASSAGTLPVTFRcLEENLGIDKRVTRFVLPVGATINMD 399
Cdd:PRK13628 222 GCMLFVALV-VNPLIVFWKIRRNPYPLvFTCLRESGVTAFFTRSSAANIPVNMA-LCEKLGLDEDTYSVSIPLGATINMA 299

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254478  400 GTALYEAVAAIFIAQMNGVVLDGGQIVTVSLTATLASVGAASIPSAGLvtmLLILTAVGL 459
Cdd:PRK13628 300 GAAITITVLTLAAVHTLGIPVDLPTALLLSVVAAISACGASGVAGGSL---LLIPLACSL 356
SstT COG3633
Na+/serine and Na+/threonine symporter SstT [Amino acid transport and metabolism];
54-459 1.88e-09

Na+/serine and Na+/threonine symporter SstT [Amino acid transport and metabolism];


Pssm-ID: 442850  Cd Length: 406  Bit Score: 59.80  E-value: 1.88e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254478  54 VILGAVCGGLLRLASPihpDVVMLIAFPGDILMRMLK----MLILPLIISSLitglsgldakASGRLGTRA-----MVYY 124
Cdd:COG3633  19 ILIGLVLGILLALLSP---EAAKSVGLLGTLFVGALKavapILVFVLVMSAI----------ANHKQGQKTnmkpiIVLY 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254478 125 MSTTIIAAVLGVILvlaihpgnpklkkqlgpgkkndevssldAFLdlirnlFPENLVqacfqqiqtvtkkvLVAPppDEE 204
Cdd:COG3633  86 LLGTFLAALVAVVA----------------------------SFL------FPTTLT--------------LVAA--AAD 115

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254478 205 ANATSAVVSLLNETVTevpeetKMV------IKKGlefkdgmNVLGLIGFFIAFGIAMGKMGDQAKLMvdfFNILNEIVM 278
Cdd:COG3633 116 LTPPGGIGEVLKTLLL------NVVdnpvnaLANA-------NYIGILAWAIGLGLALRHASDTTKTV---LSDLSDAVS 179

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254478 279 KLVIMIMWYSPLGIACLICGKI------IAIKDLEVVARQLGMyMVTVIIGLIihggiflPLIYFVVTRKNPFSF-FAGI 351
Cdd:COG3633 180 KIVRWVIRFAPLGIFGLVASTVattgfsALLGYAHLLAVLVGC-MLFVALVVN-------PLIVFLKIRRNPYPLvFTCL 251

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254478 352 FQAWITALGTASSAGTLPVTFRcLEENLGIDKRVTRFVLPVGATINMDGtalyeavAAIFIAQMN-------GVVLDGGQ 424
Cdd:COG3633 252 RESGITAFFTRSSAANIPVNMA-LCEKLGLDEDTYSVSIPLGATINMAG-------AAITITVLTlaavhtlGIEVDLPT 323

                       410       420       430
                ....*....|....*....|....*....|....*
gi 40254478 425 IVTVSLTATLASVGAASIPSAGLvtmLLILTAVGL 459
Cdd:COG3633 324 ALLLSVVAAVSACGASGVAGGSL---LLIPLACSL 355
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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