NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|4504721|ref|NP_002189|]
View 

interferon regulatory factor 1 isoform 1 [Homo sapiens]

Protein Classification

interferon regulatory factor( domain architecture ID 10457092)

interferon regulatory factor is a transcription factor involved in host immune response, hematopoietic differentiation, and immunomodulation

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
IRF pfam00605
Interferon regulatory factor transcription factor; This family of transcription factors are ...
 7-112 4.25e-65

Interferon regulatory factor transcription factor; This family of transcription factors are important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. Three of the five conserved tryptophan residues bind to DNA.


:

Pssm-ID: 459863  Cd Length: 106  Bit Score: 200.48  E-value: 4.25e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504721      7 RMRPWLEMQINSNQIPGLIWINKEEMIFQIPWKHAAKHGWDINKDACLFRSWAIHTGRYKAGEKEPDPKTWKANFRCAMN 86
Cdd:pfam00605   1 RLRPWLVEQIDSGKYPGLEWLDEEKTIFRIPWKHASRQDWNQEEDAAIFKAWAVHTGKYREGVDKPDPATWKTNFRCALN 80

                          90       100
                  ....*....|....*....|....*.
gi 4504721     87 SLPDIEEVKDQSRNKGSSAVRVYRML 112
Cdd:pfam00605  81 KLPDFEEVKDRSKDDGSDPYKVYRIL 106
 
Name Accession Description Interval E-value
IRF pfam00605
Interferon regulatory factor transcription factor; This family of transcription factors are ...
 7-112 4.25e-65

Interferon regulatory factor transcription factor; This family of transcription factors are important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. Three of the five conserved tryptophan residues bind to DNA.


Pssm-ID: 459863  Cd Length: 106  Bit Score: 200.48  E-value: 4.25e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504721      7 RMRPWLEMQINSNQIPGLIWINKEEMIFQIPWKHAAKHGWDINKDACLFRSWAIHTGRYKAGEKEPDPKTWKANFRCAMN 86
Cdd:pfam00605   1 RLRPWLVEQIDSGKYPGLEWLDEEKTIFRIPWKHASRQDWNQEEDAAIFKAWAVHTGKYREGVDKPDPATWKTNFRCALN 80

                          90       100
                  ....*....|....*....|....*.
gi 4504721     87 SLPDIEEVKDQSRNKGSSAVRVYRML 112
Cdd:pfam00605  81 KLPDFEEVKDRSKDDGSDPYKVYRIL 106
IRF cd00103
Interferon Regulatory Factor (IRF); also known as tryptophan pentad repeat. The family of IRF ...
 5-113 2.97e-52

Interferon Regulatory Factor (IRF); also known as tryptophan pentad repeat. The family of IRF transcription factors is important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. The IRF family is characterized by a unique 'tryptophan cluster' DNA-binding region. Viral IRFs bind to cellular IRFs; block type I and II interferons and host IRF-mediated transcriptional activation.


Pssm-ID: 238051  Cd Length: 107  Bit Score: 167.47  E-value: 2.97e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504721    5 RMRMRPWLEMQINSNQIPGLIWINKEEMIFQIPWKHAAKHGwDINKDACLFRSWAIHTGRYKAGEkEPDPKTWKANFRCA 84
Cdd:cd00103   1 KMRLRPWLVEQVDSGTYPGLIWLDEEKTIFRIPWKHAARHD-VQEADAKIFKAWAVERGIYQPGG-TPDPAEWKARLLCA 78

                        90       100
                ....*....|....*....|....*....
gi 4504721   85 MNSLPDIEEVKDQSRNKGSSAVRVYRMLP 113
Cdd:cd00103  79 LRSSRGFEEVKDKSKDTPGDPHRVYRLLP 107
IRF smart00348
interferon regulatory factor; interferon regulatory factor, also known as trytophan pentad ...
 7-114 4.36e-52

interferon regulatory factor; interferon regulatory factor, also known as trytophan pentad repeat


Pssm-ID: 128642  Cd Length: 107  Bit Score: 167.12  E-value: 4.36e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504721       7 RMRPWLEMQINSNQIPGLIWINKEEMIFQIPWKHAAKHGWDINKDACLFRSWAIHTGRYKAGEKEPDPKTWKANFRCAMN 86
Cdd:smart00348   1 RLRPWLVEQVESGQYPGLCWEDEEKTRFRIPWKHAGRSGFDEERDAEIFKAYCVARGIYQPGGRSPDPKTWKARLRCALR 80

                           90       100
                   ....*....|....*....|....*...
gi 4504721      87 SLPDIEEVKDQSRnKGSSAVRVYRMLPP 114
Cdd:smart00348  81 KSRDFEEIKDAST-DPPDPYRVYRLLPE 107
 
Name Accession Description Interval E-value
IRF pfam00605
Interferon regulatory factor transcription factor; This family of transcription factors are ...
 7-112 4.25e-65

Interferon regulatory factor transcription factor; This family of transcription factors are important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. Three of the five conserved tryptophan residues bind to DNA.


Pssm-ID: 459863  Cd Length: 106  Bit Score: 200.48  E-value: 4.25e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504721      7 RMRPWLEMQINSNQIPGLIWINKEEMIFQIPWKHAAKHGWDINKDACLFRSWAIHTGRYKAGEKEPDPKTWKANFRCAMN 86
Cdd:pfam00605   1 RLRPWLVEQIDSGKYPGLEWLDEEKTIFRIPWKHASRQDWNQEEDAAIFKAWAVHTGKYREGVDKPDPATWKTNFRCALN 80

                          90       100
                  ....*....|....*....|....*.
gi 4504721     87 SLPDIEEVKDQSRNKGSSAVRVYRML 112
Cdd:pfam00605  81 KLPDFEEVKDRSKDDGSDPYKVYRIL 106
IRF cd00103
Interferon Regulatory Factor (IRF); also known as tryptophan pentad repeat. The family of IRF ...
 5-113 2.97e-52

Interferon Regulatory Factor (IRF); also known as tryptophan pentad repeat. The family of IRF transcription factors is important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. The IRF family is characterized by a unique 'tryptophan cluster' DNA-binding region. Viral IRFs bind to cellular IRFs; block type I and II interferons and host IRF-mediated transcriptional activation.


Pssm-ID: 238051  Cd Length: 107  Bit Score: 167.47  E-value: 2.97e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504721    5 RMRMRPWLEMQINSNQIPGLIWINKEEMIFQIPWKHAAKHGwDINKDACLFRSWAIHTGRYKAGEkEPDPKTWKANFRCA 84
Cdd:cd00103   1 KMRLRPWLVEQVDSGTYPGLIWLDEEKTIFRIPWKHAARHD-VQEADAKIFKAWAVERGIYQPGG-TPDPAEWKARLLCA 78

                        90       100
                ....*....|....*....|....*....
gi 4504721   85 MNSLPDIEEVKDQSRNKGSSAVRVYRMLP 113
Cdd:cd00103  79 LRSSRGFEEVKDKSKDTPGDPHRVYRLLP 107
IRF smart00348
interferon regulatory factor; interferon regulatory factor, also known as trytophan pentad ...
 7-114 4.36e-52

interferon regulatory factor; interferon regulatory factor, also known as trytophan pentad repeat


Pssm-ID: 128642  Cd Length: 107  Bit Score: 167.12  E-value: 4.36e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504721       7 RMRPWLEMQINSNQIPGLIWINKEEMIFQIPWKHAAKHGWDINKDACLFRSWAIHTGRYKAGEKEPDPKTWKANFRCAMN 86
Cdd:smart00348   1 RLRPWLVEQVESGQYPGLCWEDEEKTRFRIPWKHAGRSGFDEERDAEIFKAYCVARGIYQPGGRSPDPKTWKARLRCALR 80

                           90       100
                   ....*....|....*....|....*...
gi 4504721      87 SLPDIEEVKDQSRnKGSSAVRVYRMLPP 114
Cdd:smart00348  81 KSRDFEEIKDAST-DPPDPYRVYRLLPE 107
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH