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Conserved domains on  [gi|4502673|ref|NP_001768|]
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leukocyte surface antigen CD47 isoform 1 precursor [Homo sapiens]

Protein Classification

immunoglobulin domain-containing family protein; immunoglobulin domain-containing protein( domain architecture ID 11610724)

immunoglobulin (Ig) domain-containing family protein is a member of a large superfamily containing cell surface antigen receptors, co-receptors and co-stimulatory molecules of the immune system, molecules involved in antigen presentation to lymphocytes, cell adhesion molecules, certain cytokine receptors and intracellular muscle proteins; immunoglobulin domains are typically divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets| immunoglobulin (Ig) domain-containing protein adopts a fold comprised of a sandwich of two beta sheets and may function in cell adhesion and/or pattern recognition

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IgV_CD47 cd16090
Immunoglobulin variable region (IgV) in Cluster of Differentiation (CD) 47; The members here ...
 20-133 1.55e-67

Immunoglobulin variable region (IgV) in Cluster of Differentiation (CD) 47; The members here are composed of immunoglobulin variable (IgV) region in the Cluster of Differentiation (CD) 47 (also known as integrin associated protein/IAP). CD47 partners with membrane integrins and binds thrombospondin-1 (TSP-1) and signal-regulatory protein alpha (SIRP alpha). It is involved in apoptosis, proliferation, adhesion, migration, and immune and angiogenic responses. Members of the IgV family are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond.


:

Pssm-ID: 409511  Cd Length: 112  Bit Score: 206.71  E-value: 1.55e-67
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502673   20 LLFNKTKSVEFTFCNDTVVIPCFVTNMEAQNTTEVYVKWKFKGRDIYTFDGALNKSTVPTDFSSAKIEVSQLLKGDASLK 99
Cdd:cd16090   1 LLFNKIKSVEITDCNKTVVLPCYVTNLEANNINEMFVKWKFQGKDIFSFDGAENKVTRNPAFSSANILSSDLLKGNASLT 80

                        90       100       110
                ....*....|....*....|....*....|....
gi 4502673  100 MDKSDAVshTGNYTCEVTELTREGETIIELKYRV 133
Cdd:cd16090  81 LSKAEAV--LGNYTCEVTELNREGETTVELKYRS 112
CD47 pfam04549
CD47 transmembrane region; This family represents the transmembrane region of CD47 leukocyte ...
 144-292 8.49e-57

CD47 transmembrane region; This family represents the transmembrane region of CD47 leukocyte antigen.


:

Pssm-ID: 367985  Cd Length: 147  Bit Score: 180.51  E-value: 8.49e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502673    144 LIVIFPIFAILLFWGQFGIKTLKYRSggMDEKTIALLVAGLVITVIVIVGAILFVPGEYSLKNATGLGLIVTSTGILILL 223
Cdd:pfam04549   1 LIIILLILAIILFWGQLGIITLKYKS--VLKKKIYLYVAGLWITIIVIVGAYLFIPGGYSFKNVIGLGLIVLPAVILIFL 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 4502673    224 HYYVFSTAIGLTSFVIAILVIQVIAYILAVVGLSLCIAACIPMHGPLLISGLSILALAQLLGLVYMKFV 292
Cdd:pfam04549  79 QYYLFKTVFKMTYFVIAILILQVIGYVLAVVGLALCVSACPPVYGSLLISGLGIIALAELLGLVYLKIF 147
 
Name Accession Description Interval E-value
IgV_CD47 cd16090
Immunoglobulin variable region (IgV) in Cluster of Differentiation (CD) 47; The members here ...
 20-133 1.55e-67

Immunoglobulin variable region (IgV) in Cluster of Differentiation (CD) 47; The members here are composed of immunoglobulin variable (IgV) region in the Cluster of Differentiation (CD) 47 (also known as integrin associated protein/IAP). CD47 partners with membrane integrins and binds thrombospondin-1 (TSP-1) and signal-regulatory protein alpha (SIRP alpha). It is involved in apoptosis, proliferation, adhesion, migration, and immune and angiogenic responses. Members of the IgV family are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond.


Pssm-ID: 409511  Cd Length: 112  Bit Score: 206.71  E-value: 1.55e-67
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502673   20 LLFNKTKSVEFTFCNDTVVIPCFVTNMEAQNTTEVYVKWKFKGRDIYTFDGALNKSTVPTDFSSAKIEVSQLLKGDASLK 99
Cdd:cd16090   1 LLFNKIKSVEITDCNKTVVLPCYVTNLEANNINEMFVKWKFQGKDIFSFDGAENKVTRNPAFSSANILSSDLLKGNASLT 80

                        90       100       110
                ....*....|....*....|....*....|....
gi 4502673  100 MDKSDAVshTGNYTCEVTELTREGETIIELKYRV 133
Cdd:cd16090  81 LSKAEAV--LGNYTCEVTELNREGETTVELKYRS 112
CD47 pfam04549
CD47 transmembrane region; This family represents the transmembrane region of CD47 leukocyte ...
 144-292 8.49e-57

CD47 transmembrane region; This family represents the transmembrane region of CD47 leukocyte antigen.


Pssm-ID: 367985  Cd Length: 147  Bit Score: 180.51  E-value: 8.49e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502673    144 LIVIFPIFAILLFWGQFGIKTLKYRSggMDEKTIALLVAGLVITVIVIVGAILFVPGEYSLKNATGLGLIVTSTGILILL 223
Cdd:pfam04549   1 LIIILLILAIILFWGQLGIITLKYKS--VLKKKIYLYVAGLWITIIVIVGAYLFIPGGYSFKNVIGLGLIVLPAVILIFL 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 4502673    224 HYYVFSTAIGLTSFVIAILVIQVIAYILAVVGLSLCIAACIPMHGPLLISGLSILALAQLLGLVYMKFV 292
Cdd:pfam04549  79 QYYLFKTVFKMTYFVIAILILQVIGYVLAVVGLALCVSACPPVYGSLLISGLGIIALAELLGLVYLKIF 147
V-set_CD47 pfam08204
CD47 immunoglobulin-like domain; This family represents the CD47 leukocyte antigen V-set like ...
 20-136 5.90e-40

CD47 immunoglobulin-like domain; This family represents the CD47 leukocyte antigen V-set like Ig domain.


Pssm-ID: 400488  Cd Length: 93  Bit Score: 135.28  E-value: 5.90e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502673     20 LLFNKTKSVEFTFCNDTVVIPCFVTNMEAQNTTEVYVKWKFKGRDIYTFDGALNKSTvptdfssakievsqllkgdasLK 99
Cdd:pfam08204   1 LVFNNTKSVEYTACNDTVVIPCDVDNLEYNNISEVHVKWKFNNKDIFIFNGTNNIST---------------------LK 59

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 4502673    100 MDKSDAVshTGNYTCEVTELTREGETIIELKYrVVSW 136
Cdd:pfam08204  60 FDFSDAL--SGNYTCEVTELFNEGKTTIELKY-VVSW 93
PHA03042 PHA03042
CD47-like protein; Provisional
 23-287 8.71e-16

CD47-like protein; Provisional


Pssm-ID: 222964 [Multi-domain]  Cd Length: 286  Bit Score: 76.29  E-value: 8.71e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502673    23 NKTKSVEFTFCNDTVVIPCFVTNMEAQNTTEVYVKWKFKGRDIyTFDGALNKSTVPTDFSSakievsqllkgdaslkmdk 102
Cdd:PHA03042  20 NKVSTYIYTTCNKTIVIVCNLNLLIYYNISNIHINWKFNNKVI-FKKNNTNTSSLKFNFSK------------------- 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502673   103 sdavSHTGNYTCEVTELTREGETIIELKYrVVSWFSPNENILIVIFPIFAILLFWGQFGIKTLKYRSggmDEKTIALLVA 182
Cdd:PHA03042  80 ----NLSGNYTCEAINKFNKIKNTIELQY-VIKWFTSEEINVILSLLSIYIIILWGTIITLTFKINK---LKKIIYLYAI 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502673   183 GLVITVIVIVGA-ILFVPGEYSLKNATGLGLIVTSTGILILLHYYVFSTAIGLTSFVIaILVIQVIAYILAVVGLSLCIA 261
Cdd:PHA03042 152 SIWITLIMLVGQyMIGLNTNYIFVKIQGIILIQVSIFSSIFLQIILYKKIKNSYLLII-VIILKVISYIISFIVIILSFI 230

                        250       260
                 ....*....|....*....|....*..
gi 4502673   262 ACI-PMHGPLLISGLSILALAQLLGLV 287
Cdd:PHA03042 231 GCYnSIYGYLFIYKLLFINILELSSLV 257
 
Name Accession Description Interval E-value
IgV_CD47 cd16090
Immunoglobulin variable region (IgV) in Cluster of Differentiation (CD) 47; The members here ...
 20-133 1.55e-67

Immunoglobulin variable region (IgV) in Cluster of Differentiation (CD) 47; The members here are composed of immunoglobulin variable (IgV) region in the Cluster of Differentiation (CD) 47 (also known as integrin associated protein/IAP). CD47 partners with membrane integrins and binds thrombospondin-1 (TSP-1) and signal-regulatory protein alpha (SIRP alpha). It is involved in apoptosis, proliferation, adhesion, migration, and immune and angiogenic responses. Members of the IgV family are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond.


Pssm-ID: 409511  Cd Length: 112  Bit Score: 206.71  E-value: 1.55e-67
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502673   20 LLFNKTKSVEFTFCNDTVVIPCFVTNMEAQNTTEVYVKWKFKGRDIYTFDGALNKSTVPTDFSSAKIEVSQLLKGDASLK 99
Cdd:cd16090   1 LLFNKIKSVEITDCNKTVVLPCYVTNLEANNINEMFVKWKFQGKDIFSFDGAENKVTRNPAFSSANILSSDLLKGNASLT 80

                        90       100       110
                ....*....|....*....|....*....|....
gi 4502673  100 MDKSDAVshTGNYTCEVTELTREGETIIELKYRV 133
Cdd:cd16090  81 LSKAEAV--LGNYTCEVTELNREGETTVELKYRS 112
CD47 pfam04549
CD47 transmembrane region; This family represents the transmembrane region of CD47 leukocyte ...
 144-292 8.49e-57

CD47 transmembrane region; This family represents the transmembrane region of CD47 leukocyte antigen.


Pssm-ID: 367985  Cd Length: 147  Bit Score: 180.51  E-value: 8.49e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502673    144 LIVIFPIFAILLFWGQFGIKTLKYRSggMDEKTIALLVAGLVITVIVIVGAILFVPGEYSLKNATGLGLIVTSTGILILL 223
Cdd:pfam04549   1 LIIILLILAIILFWGQLGIITLKYKS--VLKKKIYLYVAGLWITIIVIVGAYLFIPGGYSFKNVIGLGLIVLPAVILIFL 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 4502673    224 HYYVFSTAIGLTSFVIAILVIQVIAYILAVVGLSLCIAACIPMHGPLLISGLSILALAQLLGLVYMKFV 292
Cdd:pfam04549  79 QYYLFKTVFKMTYFVIAILILQVIGYVLAVVGLALCVSACPPVYGSLLISGLGIIALAELLGLVYLKIF 147
V-set_CD47 pfam08204
CD47 immunoglobulin-like domain; This family represents the CD47 leukocyte antigen V-set like ...
 20-136 5.90e-40

CD47 immunoglobulin-like domain; This family represents the CD47 leukocyte antigen V-set like Ig domain.


Pssm-ID: 400488  Cd Length: 93  Bit Score: 135.28  E-value: 5.90e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502673     20 LLFNKTKSVEFTFCNDTVVIPCFVTNMEAQNTTEVYVKWKFKGRDIYTFDGALNKSTvptdfssakievsqllkgdasLK 99
Cdd:pfam08204   1 LVFNNTKSVEYTACNDTVVIPCDVDNLEYNNISEVHVKWKFNNKDIFIFNGTNNIST---------------------LK 59

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 4502673    100 MDKSDAVshTGNYTCEVTELTREGETIIELKYrVVSW 136
Cdd:pfam08204  60 FDFSDAL--SGNYTCEVTELFNEGKTTIELKY-VVSW 93
PHA03042 PHA03042
CD47-like protein; Provisional
 23-287 8.71e-16

CD47-like protein; Provisional


Pssm-ID: 222964 [Multi-domain]  Cd Length: 286  Bit Score: 76.29  E-value: 8.71e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502673    23 NKTKSVEFTFCNDTVVIPCFVTNMEAQNTTEVYVKWKFKGRDIyTFDGALNKSTVPTDFSSakievsqllkgdaslkmdk 102
Cdd:PHA03042  20 NKVSTYIYTTCNKTIVIVCNLNLLIYYNISNIHINWKFNNKVI-FKKNNTNTSSLKFNFSK------------------- 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502673   103 sdavSHTGNYTCEVTELTREGETIIELKYrVVSWFSPNENILIVIFPIFAILLFWGQFGIKTLKYRSggmDEKTIALLVA 182
Cdd:PHA03042  80 ----NLSGNYTCEAINKFNKIKNTIELQY-VIKWFTSEEINVILSLLSIYIIILWGTIITLTFKINK---LKKIIYLYAI 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502673   183 GLVITVIVIVGA-ILFVPGEYSLKNATGLGLIVTSTGILILLHYYVFSTAIGLTSFVIaILVIQVIAYILAVVGLSLCIA 261
Cdd:PHA03042 152 SIWITLIMLVGQyMIGLNTNYIFVKIQGIILIQVSIFSSIFLQIILYKKIKNSYLLII-VIILKVISYIISFIVIILSFI 230

                        250       260
                 ....*....|....*....|....*..
gi 4502673   262 ACI-PMHGPLLISGLSILALAQLLGLV 287
Cdd:PHA03042 231 GCYnSIYGYLFIYKLLFINILELSSLV 257
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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