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Conserved domains on  [gi|2775958902|ref|NP_001418863|]
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lysocardiolipin acyltransferase 1 isoform 2 [Rattus norvegicus]

Protein Classification

lysophospholipid acyltransferase family protein( domain architecture ID 10870651)

lysophospholipid acyltransferase (LPLAT) family protein may act as an acyltransferase of a de novo or remodeling pathway of glycerophospholipid biosynthesis, catalyzing the incorporation of an acyl group from either acyl-CoAs or acyl-acyl carrier proteins (acyl-ACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid

CATH:  1.10.1200.50
EC:  2.3.1.-
Gene Ontology:  GO:0016746|GO:0008654|GO:0006644
PubMed:  18287005|18931347|18718904|37611890
SCOP:  4003349

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LPLAT_LCLAT1-like cd07990
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; ...
 1-188 4.03e-86

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as Lysocardiolipin acyltransferase 1 (LCLAT1) or 1-acyl-sn-glycerol-3-phosphate acyltransferase and similar proteins.


:

Pssm-ID: 153252 [Multi-domain]  Cd Length: 193  Bit Score: 256.78  E-value: 4.03e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2775958902   1 MFGVKVVITGDAF-VPGERSVIIMNHRTRVDWMFLWNCLMRYSYLRLEKICLKSSLKSVPGFGWAMQVAAFIFIHRKWKD 79
Cdd:cd07990     7 LSGVKVVVYGDEPkLPKERALIISNHRSEVDWLVLWMLADRFGRLGRLKIVLKDSLKYPPLGGWGWQLGEFIFLKRKWEK 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2775958902  80 DKSHFEDMVDYFCAIHEPLQLLIFPEGTDLTENNKARSNDFAEKNGLQKYEYVLHPRTTGFTFVVDRLRERrnLDAVHDI 159
Cdd:cd07990    87 DEKTIKRQLKRLKDSPEPFWLLIFPEGTRFTEEKKERSQEFAEKNGLPPLKHVLLPRTKGFVAILETLRDA--VDAVYDV 164

                         170       180
                  ....*....|....*....|....*....
gi 2775958902 160 TVAYPYNIPQTEKHLLLGDFPKEIHFHVH 188
Cdd:cd07990   165 TIAYPDGKPPSEQRLLLGGKPREVHVHVR 193
Acyltransf_C pfam16076
Acyltransferase C-terminus; This domain is found at the C-terminus of several different ...
 173-247 6.27e-16

Acyltransferase C-terminus; This domain is found at the C-terminus of several different acyltransferases including 1-acyl-sn-glycerol-3-phosphate acyltransferase, acyl-CoA:lysophosphatidylglycerol acyltransferase 1 and lysocardiolipin acyltransferase 1.


:

Pssm-ID: 465006 [Multi-domain]  Cd Length: 74  Bit Score: 71.45  E-value: 6.27e-16
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2775958902 173 HLLLGdFPKEIHFHVHRYPVDTLPTSKEDLQLWCHKRWEEKEERLRSFYQgEKNFHFTGQSTVPPCKSELRVLVV 247
Cdd:pfam16076   1 SLLNG-KPSEVHMYIRRIPLEELPEDEEELAQWLHDLFVEKDKLLDYFYE-TGTFFPGKEHIIPRRLKSLLVFIF 73
 
Name Accession Description Interval E-value
LPLAT_LCLAT1-like cd07990
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; ...
 1-188 4.03e-86

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as Lysocardiolipin acyltransferase 1 (LCLAT1) or 1-acyl-sn-glycerol-3-phosphate acyltransferase and similar proteins.


Pssm-ID: 153252 [Multi-domain]  Cd Length: 193  Bit Score: 256.78  E-value: 4.03e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2775958902   1 MFGVKVVITGDAF-VPGERSVIIMNHRTRVDWMFLWNCLMRYSYLRLEKICLKSSLKSVPGFGWAMQVAAFIFIHRKWKD 79
Cdd:cd07990     7 LSGVKVVVYGDEPkLPKERALIISNHRSEVDWLVLWMLADRFGRLGRLKIVLKDSLKYPPLGGWGWQLGEFIFLKRKWEK 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2775958902  80 DKSHFEDMVDYFCAIHEPLQLLIFPEGTDLTENNKARSNDFAEKNGLQKYEYVLHPRTTGFTFVVDRLRERrnLDAVHDI 159
Cdd:cd07990    87 DEKTIKRQLKRLKDSPEPFWLLIFPEGTRFTEEKKERSQEFAEKNGLPPLKHVLLPRTKGFVAILETLRDA--VDAVYDV 164

                         170       180
                  ....*....|....*....|....*....
gi 2775958902 160 TVAYPYNIPQTEKHLLLGDFPKEIHFHVH 188
Cdd:cd07990   165 TIAYPDGKPPSEQRLLLGGKPREVHVHVR 193
PLN02510 PLN02510
probable 1-acyl-sn-glycerol-3-phosphate acyltransferase
 3-267 7.91e-60

probable 1-acyl-sn-glycerol-3-phosphate acyltransferase


Pssm-ID: 178126 [Multi-domain]  Cd Length: 374  Bit Score: 195.69  E-value: 7.91e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2775958902   3 GVKVVITGDAFVPGERSVIIMNHRTRVDWMFLWNCLMRYSYLRLEKICLKSSLKSVPGFGWAMQVAAFIFIHRKWKDDKS 82
Cdd:PLN02510   78 KTKVVFSGDKVPPEERVLLIANHRTEVDWMYLWDLALRKGCLGYIKYVLKSSLMKLPVFGWAFHIFEFIPVERKWEVDEP 157

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2775958902  83 HFEDMVDYFCAIHEPLQLLIFPEGTDLTENNKARSNDFAEKNGLQKYEYVLHPRTTGFTFVVDRLRErrNLDAVHDITVA 162
Cdd:PLN02510  158 NIRQMLSSFKDPRDPLWLALFPEGTDYTEAKCQRSQKFAAEHGLPILNNVLLPKTKGFVSCLQELRC--SLDAVYDVTIG 235

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2775958902 163 YPYNIPqTEKHLLLGDFPKEIHFHVHRYPVDTLPTSKEDLQLWCHKRWEEKEERLRSFYqgeKNFHFTGQST-----VPP 237
Cdd:PLN02510  236 YKHRCP-SFLDNVFGIDPSEVHIHIRRIPLKQIPTSEDEVSAWLMDRFQLKDQLLSDFY---AQGHFPNEGTegelsTLK 311

                         250       260       270
                  ....*....|....*....|....*....|
gi 2775958902 238 CKSELrVLVVKLLSILYWALFCSAMCLLIY 267
Cdd:PLN02510  312 CLANF-LAVIALTTVFTYLTLFSSVWFKIY 340
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 20-111 1.45e-17

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 77.01  E-value: 1.45e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2775958902   20 VIIMNHRTRVDWMFLWNCLmrYSYLRLEKICLKSSLKSVPGFGWAMQVAAFIFIHRKWKDDKSHFedMVDYFCAIHEPLQ 99
Cdd:smart00563   2 LVVANHQSFLDPLVLSALL--PRKLGRVRFVAKKELFYVPLLGWLLRLLGAIFIDRSNGRKARAA--LREAVELLKEGEW 77

                           90
                   ....*....|..
gi 2775958902  100 LLIFPEGTDLTE 111
Cdd:smart00563  78 LLIFPEGTRSRP 89
Acyltransf_C pfam16076
Acyltransferase C-terminus; This domain is found at the C-terminus of several different ...
 173-247 6.27e-16

Acyltransferase C-terminus; This domain is found at the C-terminus of several different acyltransferases including 1-acyl-sn-glycerol-3-phosphate acyltransferase, acyl-CoA:lysophosphatidylglycerol acyltransferase 1 and lysocardiolipin acyltransferase 1.


Pssm-ID: 465006 [Multi-domain]  Cd Length: 74  Bit Score: 71.45  E-value: 6.27e-16
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2775958902 173 HLLLGdFPKEIHFHVHRYPVDTLPTSKEDLQLWCHKRWEEKEERLRSFYQgEKNFHFTGQSTVPPCKSELRVLVV 247
Cdd:pfam16076   1 SLLNG-KPSEVHMYIRRIPLEELPEDEEELAQWLHDLFVEKDKLLDYFYE-TGTFFPGKEHIIPRRLKSLLVFIF 73
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 5-163 1.53e-14

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 69.23  E-value: 1.53e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2775958902   5 KVVITGDAFVP-GERSVIIMNHRTRVDWMFLWNCLmrYSYLRLEKICLKSSLKSVPGFGWAMQVAAFIFIHRKWKDDKSH 83
Cdd:pfam01553   1 RIEVHGLENLPrGGPAIVVANHQSYLDVLLLSLAL--YKRGRPLVFVAKKELFDIPLVGWLMRLLGCIFIDRKNRKDAAG 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2775958902  84 FEDMVDYfcAIHEPLQLLIFPEGTdltennkaRSNdfaeknglqkyEYVLHPRTTGFTFVVDRLRerrnldaVHDITVAY 163
Cdd:pfam01553  79 TLEYLVE--LLREGKLVVIFPEGT--------RSR-----------EGELLPFKKGAFRLAIEAG-------VPIVPVAI 130
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 1-107 8.01e-13

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 66.57  E-value: 8.01e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2775958902   1 MFGVKVVITGDAFVPGERSVIIM-NHRTRVDWMFLWNCLMRY-SYLrlekicLKSSLKSVPGFGWAMQVAAFIFIHR-KW 77
Cdd:COG0204    26 LLGVRVRVEGLENLPADGPVLIVaNHQSWLDILLLLAALPRPvRFV------AKKELFKIPLLGWLLRALGAIPVDRsKR 99

                          90       100       110
                  ....*....|....*....|....*....|
gi 2775958902  78 KDDKSHFEDMVDyfcAIHEPLQLLIFPEGT 107
Cdd:COG0204   100 RAALRALRQAVE---ALKAGESLVIFPEGT 126
AGP_acyltrn TIGR00530
1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous ...
 3-107 4.63e-07

1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous region of a collection of related proteins, several of which are known to act as 1-acyl-sn-glycerol-3-phosphate acyltransferases (EC 2.3.1.51). Proteins scoring above the trusted cutoff are likely to have the same general activity. However, there is variation among characterized members as to whether the acyl group can be donated by acyl carrier protein or coenzyme A, and in the length and saturation of the donated acyl group. 1-acyl-sn-glycerol-3-phosphate acyltransferase is also called 1-AGP acyltransferase, lysophosphatidic acid acyltransferase, and LPA acyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 129621 [Multi-domain]  Cd Length: 130  Bit Score: 48.11  E-value: 4.63e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2775958902   3 GVKVVITGDAFVPGERSVIIM-NHRTRVDwMFLWNCLMRYSYLRLEKIclksSLKSVPGFGWAMQVAAFIFIHRkwKDDK 81
Cdd:TIGR00530   1 GLKVEVVGPENLPAKSPVLVVaNHQSNLD-PLTLSAAFPPPIVFIAKK----ELKWIPFFGIMLWLTGAIFIDR--ENIR 73

                          90       100
                  ....*....|....*....|....*.
gi 2775958902  82 SHFEDMVDYFCAIHEPLQLLIFPEGT 107
Cdd:TIGR00530  74 AIATALKAAIEVLKQGRSIGVFPEGT 99
 
Name Accession Description Interval E-value
LPLAT_LCLAT1-like cd07990
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; ...
 1-188 4.03e-86

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as Lysocardiolipin acyltransferase 1 (LCLAT1) or 1-acyl-sn-glycerol-3-phosphate acyltransferase and similar proteins.


Pssm-ID: 153252 [Multi-domain]  Cd Length: 193  Bit Score: 256.78  E-value: 4.03e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2775958902   1 MFGVKVVITGDAF-VPGERSVIIMNHRTRVDWMFLWNCLMRYSYLRLEKICLKSSLKSVPGFGWAMQVAAFIFIHRKWKD 79
Cdd:cd07990     7 LSGVKVVVYGDEPkLPKERALIISNHRSEVDWLVLWMLADRFGRLGRLKIVLKDSLKYPPLGGWGWQLGEFIFLKRKWEK 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2775958902  80 DKSHFEDMVDYFCAIHEPLQLLIFPEGTDLTENNKARSNDFAEKNGLQKYEYVLHPRTTGFTFVVDRLRERrnLDAVHDI 159
Cdd:cd07990    87 DEKTIKRQLKRLKDSPEPFWLLIFPEGTRFTEEKKERSQEFAEKNGLPPLKHVLLPRTKGFVAILETLRDA--VDAVYDV 164

                         170       180
                  ....*....|....*....|....*....
gi 2775958902 160 TVAYPYNIPQTEKHLLLGDFPKEIHFHVH 188
Cdd:cd07990   165 TIAYPDGKPPSEQRLLLGGKPREVHVHVR 193
PLN02510 PLN02510
probable 1-acyl-sn-glycerol-3-phosphate acyltransferase
 3-267 7.91e-60

probable 1-acyl-sn-glycerol-3-phosphate acyltransferase


Pssm-ID: 178126 [Multi-domain]  Cd Length: 374  Bit Score: 195.69  E-value: 7.91e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2775958902   3 GVKVVITGDAFVPGERSVIIMNHRTRVDWMFLWNCLMRYSYLRLEKICLKSSLKSVPGFGWAMQVAAFIFIHRKWKDDKS 82
Cdd:PLN02510   78 KTKVVFSGDKVPPEERVLLIANHRTEVDWMYLWDLALRKGCLGYIKYVLKSSLMKLPVFGWAFHIFEFIPVERKWEVDEP 157

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2775958902  83 HFEDMVDYFCAIHEPLQLLIFPEGTDLTENNKARSNDFAEKNGLQKYEYVLHPRTTGFTFVVDRLRErrNLDAVHDITVA 162
Cdd:PLN02510  158 NIRQMLSSFKDPRDPLWLALFPEGTDYTEAKCQRSQKFAAEHGLPILNNVLLPKTKGFVSCLQELRC--SLDAVYDVTIG 235

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2775958902 163 YPYNIPqTEKHLLLGDFPKEIHFHVHRYPVDTLPTSKEDLQLWCHKRWEEKEERLRSFYqgeKNFHFTGQST-----VPP 237
Cdd:PLN02510  236 YKHRCP-SFLDNVFGIDPSEVHIHIRRIPLKQIPTSEDEVSAWLMDRFQLKDQLLSDFY---AQGHFPNEGTegelsTLK 311

                         250       260       270
                  ....*....|....*....|....*....|
gi 2775958902 238 CKSELrVLVVKLLSILYWALFCSAMCLLIY 267
Cdd:PLN02510  312 CLANF-LAVIALTTVFTYLTLFSSVWFKIY 340
PLN02380 PLN02380
1-acyl-sn-glycerol-3-phosphate acyltransferase
 17-284 1.48e-33

1-acyl-sn-glycerol-3-phosphate acyltransferase


Pssm-ID: 178006 [Multi-domain]  Cd Length: 376  Bit Score: 126.78  E-value: 1.48e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2775958902  17 ERSVIIMNHRTRVDWMFLWNCLMRYSYLRLEKICLKSSLKSVPGFGWAMQVAAFIFIHRKWKDD----KSHFEDMVDYfc 92
Cdd:PLN02380   84 EHALVISNHRSDIDWLVGWILAQRSGCLGSALAVMKKSSKFLPVIGWSMWFSEYVFLERSWAKDentlKSGFQRLKDF-- 161

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2775958902  93 aiHEPLQLLIFPEGTDLTENNKARSNDFAEKNGLQKYEYVLHPRTTGFTFVVDRLRERrnLDAVHDITVAYPYNIPQTEK 172
Cdd:PLN02380  162 --PRPFWLALFVEGTRFTQAKLLAAQEYAASRGLPVPRNVLIPRTKGFVSAVSNMRSF--VPAIYDVTVAVPKGQPAPTM 237

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2775958902 173 HLLLGDFPKEIHFHVHRYPVDTLPTSKEDLQLWCHKRWEEKEERLRSFyqgEKNFHFTGQSTVP---PCKSelrvlvvkL 249
Cdd:PLN02380  238 LRIFRGQSSVVHVHIKRHSMKELPETDDGIAQWCKDVFVAKDALLDKH---FAEDTFGDQEYQDigrPKKS--------L 306

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 2775958902 250 LSILYWAlfcsamCLLIY-LYSPVRWYFIIS----IVFFV 284
Cdd:PLN02380  307 IVVISWA------CLLILgAIKFLQWLSLLSswkgIASLA 340
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 20-111 1.45e-17

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 77.01  E-value: 1.45e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2775958902   20 VIIMNHRTRVDWMFLWNCLmrYSYLRLEKICLKSSLKSVPGFGWAMQVAAFIFIHRKWKDDKSHFedMVDYFCAIHEPLQ 99
Cdd:smart00563   2 LVVANHQSFLDPLVLSALL--PRKLGRVRFVAKKELFYVPLLGWLLRLLGAIFIDRSNGRKARAA--LREAVELLKEGEW 77

                           90
                   ....*....|..
gi 2775958902  100 LLIFPEGTDLTE 111
Cdd:smart00563  78 LLIFPEGTRSRP 89
LPLAT cd06551
Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; ...
 3-187 2.51e-16

Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Lysophospholipid acyltransferase (LPLAT) superfamily members are acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis. These proteins catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this superfamily are LPLATs such as glycerol-3-phosphate 1-acyltransferase (GPAT, PlsB), 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), lysophosphatidylcholine acyltransferase 1 (LPCAT-1), lysophosphatidylethanolamine acyltransferase (LPEAT, also known as, MBOAT2, membrane-bound O-acyltransferase domain-containing protein 2), lipid A biosynthesis lauroyl/myristoyl acyltransferase, 2-acylglycerol O-acyltransferase (MGAT), dihydroxyacetone phosphate acyltransferase (DHAPAT, also known as 1 glycerol-3-phosphate O-acyltransferase 1) and Tafazzin (the protein product of the Barth syndrome (TAZ) gene).


Pssm-ID: 153244 [Multi-domain]  Cd Length: 187  Bit Score: 75.53  E-value: 2.51e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2775958902   3 GVKVVITGDAFVPGERSVIIM-NHRTRVDWMFLWnCLMRYSYLRLEKICLK-SSLKSVPGFGWamqvAAFIFIHRKW-KD 79
Cdd:cd06551    11 FVRLEVKGPPPPPGGGPVLFVsNHSSWWDGLILF-LLLERGLRRDVYGLMDeELLERYPFFTR----LGAFSVDRDSpRS 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2775958902  80 DKSHFEDMVDYFCAIHEplQLLIFPEGTDLTEnnkarsndfaEKNGLQKYEYVLHP-RTTGFTFVVDRLR-ERRNLDAVH 157
Cdd:cd06551    86 AAKSLKYVARLLSKPGS--VVWIFPEGTRTRR----------DKRPLQFKPGVAHLaEKAGVPIVPVALRyTFELFEQFP 153

                         170       180       190
                  ....*....|....*....|....*....|...
gi 2775958902 158 DITVAYPYNIPQTEKH---LLLGDFPKEIHFHV 187
Cdd:cd06551   154 EIFVRIGPPIPYAETAlgeELAAELANRLTRLL 186
Acyltransf_C pfam16076
Acyltransferase C-terminus; This domain is found at the C-terminus of several different ...
 173-247 6.27e-16

Acyltransferase C-terminus; This domain is found at the C-terminus of several different acyltransferases including 1-acyl-sn-glycerol-3-phosphate acyltransferase, acyl-CoA:lysophosphatidylglycerol acyltransferase 1 and lysocardiolipin acyltransferase 1.


Pssm-ID: 465006 [Multi-domain]  Cd Length: 74  Bit Score: 71.45  E-value: 6.27e-16
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2775958902 173 HLLLGdFPKEIHFHVHRYPVDTLPTSKEDLQLWCHKRWEEKEERLRSFYQgEKNFHFTGQSTVPPCKSELRVLVV 247
Cdd:pfam16076   1 SLLNG-KPSEVHMYIRRIPLEELPEDEEELAQWLHDLFVEKDKLLDYFYE-TGTFFPGKEHIIPRRLKSLLVFIF 73
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 5-163 1.53e-14

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 69.23  E-value: 1.53e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2775958902   5 KVVITGDAFVP-GERSVIIMNHRTRVDWMFLWNCLmrYSYLRLEKICLKSSLKSVPGFGWAMQVAAFIFIHRKWKDDKSH 83
Cdd:pfam01553   1 RIEVHGLENLPrGGPAIVVANHQSYLDVLLLSLAL--YKRGRPLVFVAKKELFDIPLVGWLMRLLGCIFIDRKNRKDAAG 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2775958902  84 FEDMVDYfcAIHEPLQLLIFPEGTdltennkaRSNdfaeknglqkyEYVLHPRTTGFTFVVDRLRerrnldaVHDITVAY 163
Cdd:pfam01553  79 TLEYLVE--LLREGKLVVIFPEGT--------RSR-----------EGELLPFKKGAFRLAIEAG-------VPIVPVAI 130
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 1-107 8.01e-13

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 66.57  E-value: 8.01e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2775958902   1 MFGVKVVITGDAFVPGERSVIIM-NHRTRVDWMFLWNCLMRY-SYLrlekicLKSSLKSVPGFGWAMQVAAFIFIHR-KW 77
Cdd:COG0204    26 LLGVRVRVEGLENLPADGPVLIVaNHQSWLDILLLLAALPRPvRFV------AKKELFKIPLLGWLLRALGAIPVDRsKR 99

                          90       100       110
                  ....*....|....*....|....*....|
gi 2775958902  78 KDDKSHFEDMVDyfcAIHEPLQLLIFPEGT 107
Cdd:COG0204   100 RAALRALRQAVE---ALKAGESLVIFPEGT 126
LPLAT_AGPAT-like cd07989
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; ...
 1-107 1.01e-11

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.


Pssm-ID: 153251 [Multi-domain]  Cd Length: 184  Bit Score: 62.67  E-value: 1.01e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2775958902   1 MFGVKVVITGDAFVPGERSVIIM-NHRTRVDWMFLWNCLMRY-SYLrlekicLKSSLKSVPGFGWAMQVAAFIFIHR-KW 77
Cdd:cd07989     7 LLGVRVRVEGLENLPPKGPVIIVaNHQSYLDPLVLGAALPRPiRFV------AKKELFKIPFLGWLLRLLGAIPIDRgNG 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 2775958902  78 KDDKSHFEDMVDyfcAIHEPLQLLIFPEGT 107
Cdd:cd07989    81 RSAREALREAIE---ALKEGESVVIFPEGT 107
PRK14014 PRK14014
putative acyltransferase; Provisional
 103-226 1.38e-08

putative acyltransferase; Provisional


Pssm-ID: 237584 [Multi-domain]  Cd Length: 301  Bit Score: 55.24  E-value: 1.38e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2775958902 103 FPEGTDLTENNKARSNdfaeknglQKYEYVLHPRTTGFTFVVDRLRERrnLDAVHDITVAYPYNIPqTEKHLLLGDfPKE 182
Cdd:PRK14014  180 FVEGTRFTPEKHQQQQ--------SPYQHLLKPKAGGIAFALNAMGEQ--FDGLLDVTIVYPDGRP-SFWDLLSGR-VKK 247

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2775958902 183 IHFHVHRYPVDTL--------PTSKEDLQLWCHKRWEEKEERLRSFYQGEKN 226
Cdd:PRK14014  248 IVVHVRLLPIPEEligdyfndKEFRRRFQQWLNQLWQEKDQLIEQLLAQYNQ 299
AGP_acyltrn TIGR00530
1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous ...
 3-107 4.63e-07

1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous region of a collection of related proteins, several of which are known to act as 1-acyl-sn-glycerol-3-phosphate acyltransferases (EC 2.3.1.51). Proteins scoring above the trusted cutoff are likely to have the same general activity. However, there is variation among characterized members as to whether the acyl group can be donated by acyl carrier protein or coenzyme A, and in the length and saturation of the donated acyl group. 1-acyl-sn-glycerol-3-phosphate acyltransferase is also called 1-AGP acyltransferase, lysophosphatidic acid acyltransferase, and LPA acyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 129621 [Multi-domain]  Cd Length: 130  Bit Score: 48.11  E-value: 4.63e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2775958902   3 GVKVVITGDAFVPGERSVIIM-NHRTRVDwMFLWNCLMRYSYLRLEKIclksSLKSVPGFGWAMQVAAFIFIHRkwKDDK 81
Cdd:TIGR00530   1 GLKVEVVGPENLPAKSPVLVVaNHQSNLD-PLTLSAAFPPPIVFIAKK----ELKWIPFFGIMLWLTGAIFIDR--ENIR 73

                          90       100
                  ....*....|....*....|....*.
gi 2775958902  82 SHFEDMVDYFCAIHEPLQLLIFPEGT 107
Cdd:TIGR00530  74 AIATALKAAIEVLKQGRSIGVFPEGT 99
LPLAT_LPCAT1-like cd07991
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like; ...
 20-115 3.42e-04

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as lysophosphatidylcholine acyltransferase 1 (LPCAT-1), glycerol-3-phosphate acyltransferase 3 (GPAT3), and similar sequences.


Pssm-ID: 153253 [Multi-domain]  Cd Length: 211  Bit Score: 41.05  E-value: 3.42e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2775958902  20 VIIMNHRTRVDWMFLWNCLMrYSYLRlekiclKSSLKSVPGFGWAMQVAAFIFIHRKWKDD--------KSHFEDMvdyf 91
Cdd:cd07991    27 IIVANHTSFIDPLILFSDLF-PSIVA------KKELGKLPFIGTILRALGCIFVDRSEPKDrkkvveeiKERATDP---- 95

                          90       100
                  ....*....|....*....|....
gi 2775958902  92 caihEPLQLLIFPEGTdlTENNKA 115
Cdd:cd07991    96 ----NWPPILIFPEGT--TTNGKA 113
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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