NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2775958808|ref|NP_001418858|]
View 

lysocardiolipin acyltransferase 1 isoform 1 [Rattus norvegicus]

Protein Classification

lysophospholipid acyltransferase family protein( domain architecture ID 10870651)

lysophospholipid acyltransferase (LPLAT) family protein may act as an acyltransferase of a de novo or remodeling pathway of glycerophospholipid biosynthesis, catalyzing the incorporation of an acyl group from either acyl-CoAs or acyl-acyl carrier proteins (acyl-ACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid

CATH:  1.10.1200.50
EC:  2.3.1.-
Gene Ontology:  GO:0016746|GO:0008654|GO:0006644
PubMed:  18287005|18931347|18718904|37611890
SCOP:  4003349

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
LPLAT_LCLAT1-like cd07990
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; ...
 55-248 6.38e-87

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as Lysocardiolipin acyltransferase 1 (LCLAT1) or 1-acyl-sn-glycerol-3-phosphate acyltransferase and similar proteins.


:

Pssm-ID: 153252 [Multi-domain]  Cd Length: 193  Bit Score: 261.02  E-value: 6.38e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2775958808  55 VALLETMFGVKVVITGDAF-VPGERSVIIMNHRTRVDWMFLWNCLMRYSYLRLEKICLKSSLKSVPGFGWAMQVAAFIFI 133
Cdd:cd07990     1 VFLFEWLSGVKVVVYGDEPkLPKERALIISNHRSEVDWLVLWMLADRFGRLGRLKIVLKDSLKYPPLGGWGWQLGEFIFL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2775958808 134 HRKWKDDKSHFEDMVDYFCAIHEPLQLLIFPEGTDLTENNKARSNDFAEKNGLQKYEYVLHPRTTGFTFVVDRLRERrnL 213
Cdd:cd07990    81 KRKWEKDEKTIKRQLKRLKDSPEPFWLLIFPEGTRFTEEKKERSQEFAEKNGLPPLKHVLLPRTKGFVAILETLRDA--V 158

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 2775958808 214 DAVHDITVAYPYNIPQTEKHLLLGDFPKEIHFHVH 248
Cdd:cd07990   159 DAVYDVTIAYPDGKPPSEQRLLLGGKPREVHVHVR 193
Acyltransf_C pfam16076
Acyltransferase C-terminus; This domain is found at the C-terminus of several different ...
 233-307 7.35e-16

Acyltransferase C-terminus; This domain is found at the C-terminus of several different acyltransferases including 1-acyl-sn-glycerol-3-phosphate acyltransferase, acyl-CoA:lysophosphatidylglycerol acyltransferase 1 and lysocardiolipin acyltransferase 1.


:

Pssm-ID: 465006 [Multi-domain]  Cd Length: 74  Bit Score: 71.45  E-value: 7.35e-16
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2775958808 233 HLLLGdFPKEIHFHVHRYPVDTLPTSKEDLQLWCHKRWEEKEERLRSFYQgEKNFHFTGQSTVPPCKSELRVLVV 307
Cdd:pfam16076   1 SLLNG-KPSEVHMYIRRIPLEELPEDEEELAQWLHDLFVEKDKLLDYFYE-TGTFFPGKEHIIPRRLKSLLVFIF 73
 
Name Accession Description Interval E-value
LPLAT_LCLAT1-like cd07990
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; ...
 55-248 6.38e-87

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as Lysocardiolipin acyltransferase 1 (LCLAT1) or 1-acyl-sn-glycerol-3-phosphate acyltransferase and similar proteins.


Pssm-ID: 153252 [Multi-domain]  Cd Length: 193  Bit Score: 261.02  E-value: 6.38e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2775958808  55 VALLETMFGVKVVITGDAF-VPGERSVIIMNHRTRVDWMFLWNCLMRYSYLRLEKICLKSSLKSVPGFGWAMQVAAFIFI 133
Cdd:cd07990     1 VFLFEWLSGVKVVVYGDEPkLPKERALIISNHRSEVDWLVLWMLADRFGRLGRLKIVLKDSLKYPPLGGWGWQLGEFIFL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2775958808 134 HRKWKDDKSHFEDMVDYFCAIHEPLQLLIFPEGTDLTENNKARSNDFAEKNGLQKYEYVLHPRTTGFTFVVDRLRERrnL 213
Cdd:cd07990    81 KRKWEKDEKTIKRQLKRLKDSPEPFWLLIFPEGTRFTEEKKERSQEFAEKNGLPPLKHVLLPRTKGFVAILETLRDA--V 158

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 2775958808 214 DAVHDITVAYPYNIPQTEKHLLLGDFPKEIHFHVH 248
Cdd:cd07990   159 DAVYDVTIAYPDGKPPSEQRLLLGGKPREVHVHVR 193
PLN02510 PLN02510
probable 1-acyl-sn-glycerol-3-phosphate acyltransferase
 5-327 9.18e-63

probable 1-acyl-sn-glycerol-3-phosphate acyltransferase


Pssm-ID: 178126 [Multi-domain]  Cd Length: 374  Bit Score: 205.32  E-value: 9.18e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2775958808   5 KGIYFILFLFAGSFFGSIFmLGPILPLM--FINLSWYRWISSRLVAMWLTLPVALLETMFGVKVVITGDAFVPGERSVII 82
Cdd:PLN02510   19 RGLICLLVLLSTAFMMLVY-LAPVSAVLlrLFSVHYSRKATSFFFGSWLALWPFLFEKINKTKVVFSGDKVPPEERVLLI 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2775958808  83 MNHRTRVDWMFLWNCLMRYSYLRLEKICLKSSLKSVPGFGWAMQVAAFIFIHRKWKDDKSHFEDMVDYFCAIHEPLQLLI 162
Cdd:PLN02510   98 ANHRTEVDWMYLWDLALRKGCLGYIKYVLKSSLMKLPVFGWAFHIFEFIPVERKWEVDEPNIRQMLSSFKDPRDPLWLAL 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2775958808 163 FPEGTDLTENNKARSNDFAEKNGLQKYEYVLHPRTTGFTFVVDRLRErrNLDAVHDITVAYPYNIPqTEKHLLLGDFPKE 242
Cdd:PLN02510  178 FPEGTDYTEAKCQRSQKFAAEHGLPILNNVLLPKTKGFVSCLQELRC--SLDAVYDVTIGYKHRCP-SFLDNVFGIDPSE 254

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2775958808 243 IHFHVHRYPVDTLPTSKEDLQLWCHKRWEEKEERLRSFYqgeKNFHFTGQST-----VPPCKSELrVLVVKLLSILYWAL 317
Cdd:PLN02510  255 VHIHIRRIPLKQIPTSEDEVSAWLMDRFQLKDQLLSDFY---AQGHFPNEGTegelsTLKCLANF-LAVIALTTVFTYLT 330

                         330
                  ....*....|
gi 2775958808 318 FCSAMCLLIY 327
Cdd:PLN02510  331 LFSSVWFKIY 340
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 80-171 1.09e-16

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 75.47  E-value: 1.09e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2775958808   80 VIIMNHRTRVDWMFLWNCLmrYSYLRLEKICLKSSLKSVPGFGWAMQVAAFIFIHRKWKDDKSHFedMVDYFCAIHEPLQ 159
Cdd:smart00563   2 LVVANHQSFLDPLVLSALL--PRKLGRVRFVAKKELFYVPLLGWLLRLLGAIFIDRSNGRKARAA--LREAVELLKEGEW 77

                           90
                   ....*....|..
gi 2775958808  160 LLIFPEGTDLTE 171
Cdd:smart00563  78 LLIFPEGTRSRP 89
Acyltransf_C pfam16076
Acyltransferase C-terminus; This domain is found at the C-terminus of several different ...
 233-307 7.35e-16

Acyltransferase C-terminus; This domain is found at the C-terminus of several different acyltransferases including 1-acyl-sn-glycerol-3-phosphate acyltransferase, acyl-CoA:lysophosphatidylglycerol acyltransferase 1 and lysocardiolipin acyltransferase 1.


Pssm-ID: 465006 [Multi-domain]  Cd Length: 74  Bit Score: 71.45  E-value: 7.35e-16
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2775958808 233 HLLLGdFPKEIHFHVHRYPVDTLPTSKEDLQLWCHKRWEEKEERLRSFYQgEKNFHFTGQSTVPPCKSELRVLVV 307
Cdd:pfam16076   1 SLLNG-KPSEVHMYIRRIPLEELPEDEEELAQWLHDLFVEKDKLLDYFYE-TGTFFPGKEHIIPRRLKSLLVFIF 73
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 65-223 5.67e-14

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 68.07  E-value: 5.67e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2775958808  65 KVVITGDAFVP-GERSVIIMNHRTRVDWMFLWNCLmrYSYLRLEKICLKSSLKSVPGFGWAMQVAAFIFIHRKWKDDKSH 143
Cdd:pfam01553   1 RIEVHGLENLPrGGPAIVVANHQSYLDVLLLSLAL--YKRGRPLVFVAKKELFDIPLVGWLMRLLGCIFIDRKNRKDAAG 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2775958808 144 FEDMVDYfcAIHEPLQLLIFPEGTdltennkaRSNdfaeknglqkyEYVLHPRTTGFTFVVDRLRerrnldaVHDITVAY 223
Cdd:pfam01553  79 TLEYLVE--LLREGKLVVIFPEGT--------RSR-----------EGELLPFKKGAFRLAIEAG-------VPIVPVAI 130
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 31-167 1.86e-13

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 68.88  E-value: 1.86e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2775958808  31 LMFINLSWYRWISSRLVAMWLTLpvalletmFGVKVVITGDAFVPGERSVIIM-NHRTRVDWMFLWNCLMRY-SYLrlek 108
Cdd:COG0204     4 LFLLLRRFRYRLVRLWARLLLRL--------LGVRVRVEGLENLPADGPVLIVaNHQSWLDILLLLAALPRPvRFV---- 71

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2775958808 109 icLKSSLKSVPGFGWAMQVAAFIFIHR-KWKDDKSHFEDMVDyfcAIHEPLQLLIFPEGT 167
Cdd:COG0204    72 --AKKELFKIPLLGWLLRALGAIPVDRsKRRAALRALRQAVE---ALKAGESLVIFPEGT 126
AGP_acyltrn TIGR00530
1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous ...
 63-167 7.54e-07

1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous region of a collection of related proteins, several of which are known to act as 1-acyl-sn-glycerol-3-phosphate acyltransferases (EC 2.3.1.51). Proteins scoring above the trusted cutoff are likely to have the same general activity. However, there is variation among characterized members as to whether the acyl group can be donated by acyl carrier protein or coenzyme A, and in the length and saturation of the donated acyl group. 1-acyl-sn-glycerol-3-phosphate acyltransferase is also called 1-AGP acyltransferase, lysophosphatidic acid acyltransferase, and LPA acyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 129621 [Multi-domain]  Cd Length: 130  Bit Score: 47.73  E-value: 7.54e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2775958808  63 GVKVVITGDAFVPGERSVIIM-NHRTRVDwMFLWNCLMRYSYLRLEKIclksSLKSVPGFGWAMQVAAFIFIHRkwKDDK 141
Cdd:TIGR00530   1 GLKVEVVGPENLPAKSPVLVVaNHQSNLD-PLTLSAAFPPPIVFIAKK----ELKWIPFFGIMLWLTGAIFIDR--ENIR 73

                          90       100
                  ....*....|....*....|....*.
gi 2775958808 142 SHFEDMVDYFCAIHEPLQLLIFPEGT 167
Cdd:TIGR00530  74 AIATALKAAIEVLKQGRSIGVFPEGT 99
 
Name Accession Description Interval E-value
LPLAT_LCLAT1-like cd07990
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; ...
 55-248 6.38e-87

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as Lysocardiolipin acyltransferase 1 (LCLAT1) or 1-acyl-sn-glycerol-3-phosphate acyltransferase and similar proteins.


Pssm-ID: 153252 [Multi-domain]  Cd Length: 193  Bit Score: 261.02  E-value: 6.38e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2775958808  55 VALLETMFGVKVVITGDAF-VPGERSVIIMNHRTRVDWMFLWNCLMRYSYLRLEKICLKSSLKSVPGFGWAMQVAAFIFI 133
Cdd:cd07990     1 VFLFEWLSGVKVVVYGDEPkLPKERALIISNHRSEVDWLVLWMLADRFGRLGRLKIVLKDSLKYPPLGGWGWQLGEFIFL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2775958808 134 HRKWKDDKSHFEDMVDYFCAIHEPLQLLIFPEGTDLTENNKARSNDFAEKNGLQKYEYVLHPRTTGFTFVVDRLRERrnL 213
Cdd:cd07990    81 KRKWEKDEKTIKRQLKRLKDSPEPFWLLIFPEGTRFTEEKKERSQEFAEKNGLPPLKHVLLPRTKGFVAILETLRDA--V 158

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 2775958808 214 DAVHDITVAYPYNIPQTEKHLLLGDFPKEIHFHVH 248
Cdd:cd07990   159 DAVYDVTIAYPDGKPPSEQRLLLGGKPREVHVHVR 193
PLN02510 PLN02510
probable 1-acyl-sn-glycerol-3-phosphate acyltransferase
 5-327 9.18e-63

probable 1-acyl-sn-glycerol-3-phosphate acyltransferase


Pssm-ID: 178126 [Multi-domain]  Cd Length: 374  Bit Score: 205.32  E-value: 9.18e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2775958808   5 KGIYFILFLFAGSFFGSIFmLGPILPLM--FINLSWYRWISSRLVAMWLTLPVALLETMFGVKVVITGDAFVPGERSVII 82
Cdd:PLN02510   19 RGLICLLVLLSTAFMMLVY-LAPVSAVLlrLFSVHYSRKATSFFFGSWLALWPFLFEKINKTKVVFSGDKVPPEERVLLI 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2775958808  83 MNHRTRVDWMFLWNCLMRYSYLRLEKICLKSSLKSVPGFGWAMQVAAFIFIHRKWKDDKSHFEDMVDYFCAIHEPLQLLI 162
Cdd:PLN02510   98 ANHRTEVDWMYLWDLALRKGCLGYIKYVLKSSLMKLPVFGWAFHIFEFIPVERKWEVDEPNIRQMLSSFKDPRDPLWLAL 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2775958808 163 FPEGTDLTENNKARSNDFAEKNGLQKYEYVLHPRTTGFTFVVDRLRErrNLDAVHDITVAYPYNIPqTEKHLLLGDFPKE 242
Cdd:PLN02510  178 FPEGTDYTEAKCQRSQKFAAEHGLPILNNVLLPKTKGFVSCLQELRC--SLDAVYDVTIGYKHRCP-SFLDNVFGIDPSE 254

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2775958808 243 IHFHVHRYPVDTLPTSKEDLQLWCHKRWEEKEERLRSFYqgeKNFHFTGQST-----VPPCKSELrVLVVKLLSILYWAL 317
Cdd:PLN02510  255 VHIHIRRIPLKQIPTSEDEVSAWLMDRFQLKDQLLSDFY---AQGHFPNEGTegelsTLKCLANF-LAVIALTTVFTYLT 330

                         330
                  ....*....|
gi 2775958808 318 FCSAMCLLIY 327
Cdd:PLN02510  331 LFSSVWFKIY 340
PLN02380 PLN02380
1-acyl-sn-glycerol-3-phosphate acyltransferase
 10-344 2.38e-34

1-acyl-sn-glycerol-3-phosphate acyltransferase


Pssm-ID: 178006 [Multi-domain]  Cd Length: 376  Bit Score: 130.25  E-value: 2.38e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2775958808  10 ILFLFAGSFFGSI----FMLgpILPLmfiNLSWYRWISSRLV-AMWLTLpVALLETMFGVKVVITGDA----FVPGERSV 80
Cdd:PLN02380   14 LLFLLSGLIVNLIqavcFIL--VRPL---SKSLYRRINRAVAeLLWLEL-IWLVDWWAGVKVQLYADEetfeLMGKEHAL 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2775958808  81 IIMNHRTRVDWMFLWNCLMRYSYLRLEKICLKSSLKSVPGFGWAMQVAAFIFIHRKWKDD----KSHFEDMVDYfcaiHE 156
Cdd:PLN02380   88 VISNHRSDIDWLVGWILAQRSGCLGSALAVMKKSSKFLPVIGWSMWFSEYVFLERSWAKDentlKSGFQRLKDF----PR 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2775958808 157 PLQLLIFPEGTDLTENNKARSNDFAEKNGLQKYEYVLHPRTTGFTFVVDRLRERrnLDAVHDITVAYPYNIPQTEKHLLL 236
Cdd:PLN02380  164 PFWLALFVEGTRFTQAKLLAAQEYAASRGLPVPRNVLIPRTKGFVSAVSNMRSF--VPAIYDVTVAVPKGQPAPTMLRIF 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2775958808 237 GDFPKEIHFHVHRYPVDTLPTSKEDLQLWCHKRWEEKEERLRSFyqgEKNFHFTGQSTVP---PCKSelrvlvvkLLSIL 313
Cdd:PLN02380  242 RGQSSVVHVHIKRHSMKELPETDDGIAQWCKDVFVAKDALLDKH---FAEDTFGDQEYQDigrPKKS--------LIVVI 310

                         330       340       350
                  ....*....|....*....|....*....|....*.
gi 2775958808 314 YWAlfcsamCLLIY-LYSPVRWYFIIS----IVFFV 344
Cdd:PLN02380  311 SWA------CLLILgAIKFLQWLSLLSswkgIASLA 340
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 80-171 1.09e-16

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 75.47  E-value: 1.09e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2775958808   80 VIIMNHRTRVDWMFLWNCLmrYSYLRLEKICLKSSLKSVPGFGWAMQVAAFIFIHRKWKDDKSHFedMVDYFCAIHEPLQ 159
Cdd:smart00563   2 LVVANHQSFLDPLVLSALL--PRKLGRVRFVAKKELFYVPLLGWLLRLLGAIFIDRSNGRKARAA--LREAVELLKEGEW 77

                           90
                   ....*....|..
gi 2775958808  160 LLIFPEGTDLTE 171
Cdd:smart00563  78 LLIFPEGTRSRP 89
Acyltransf_C pfam16076
Acyltransferase C-terminus; This domain is found at the C-terminus of several different ...
 233-307 7.35e-16

Acyltransferase C-terminus; This domain is found at the C-terminus of several different acyltransferases including 1-acyl-sn-glycerol-3-phosphate acyltransferase, acyl-CoA:lysophosphatidylglycerol acyltransferase 1 and lysocardiolipin acyltransferase 1.


Pssm-ID: 465006 [Multi-domain]  Cd Length: 74  Bit Score: 71.45  E-value: 7.35e-16
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2775958808 233 HLLLGdFPKEIHFHVHRYPVDTLPTSKEDLQLWCHKRWEEKEERLRSFYQgEKNFHFTGQSTVPPCKSELRVLVV 307
Cdd:pfam16076   1 SLLNG-KPSEVHMYIRRIPLEELPEDEEELAQWLHDLFVEKDKLLDYFYE-TGTFFPGKEHIIPRRLKSLLVFIF 73
LPLAT cd06551
Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; ...
 63-247 2.08e-15

Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Lysophospholipid acyltransferase (LPLAT) superfamily members are acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis. These proteins catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this superfamily are LPLATs such as glycerol-3-phosphate 1-acyltransferase (GPAT, PlsB), 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), lysophosphatidylcholine acyltransferase 1 (LPCAT-1), lysophosphatidylethanolamine acyltransferase (LPEAT, also known as, MBOAT2, membrane-bound O-acyltransferase domain-containing protein 2), lipid A biosynthesis lauroyl/myristoyl acyltransferase, 2-acylglycerol O-acyltransferase (MGAT), dihydroxyacetone phosphate acyltransferase (DHAPAT, also known as 1 glycerol-3-phosphate O-acyltransferase 1) and Tafazzin (the protein product of the Barth syndrome (TAZ) gene).


Pssm-ID: 153244 [Multi-domain]  Cd Length: 187  Bit Score: 73.60  E-value: 2.08e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2775958808  63 GVKVVITGDAFVPGERSVIIM-NHRTRVDWMFLWnCLMRYSYLRLEKICLK-SSLKSVPGFGWamqvAAFIFIHRKW-KD 139
Cdd:cd06551    11 FVRLEVKGPPPPPGGGPVLFVsNHSSWWDGLILF-LLLERGLRRDVYGLMDeELLERYPFFTR----LGAFSVDRDSpRS 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2775958808 140 DKSHFEDMVDYFCAIHEplQLLIFPEGTDLTEnnkarsndfaEKNGLQKYEYVLHP-RTTGFTFVVDRLR-ERRNLDAVH 217
Cdd:cd06551    86 AAKSLKYVARLLSKPGS--VVWIFPEGTRTRR----------DKRPLQFKPGVAHLaEKAGVPIVPVALRyTFELFEQFP 153

                         170       180       190
                  ....*....|....*....|....*....|...
gi 2775958808 218 DITVAYPYNIPQTEKH---LLLGDFPKEIHFHV 247
Cdd:cd06551   154 EIFVRIGPPIPYAETAlgeELAAELANRLTRLL 186
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 65-223 5.67e-14

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 68.07  E-value: 5.67e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2775958808  65 KVVITGDAFVP-GERSVIIMNHRTRVDWMFLWNCLmrYSYLRLEKICLKSSLKSVPGFGWAMQVAAFIFIHRKWKDDKSH 143
Cdd:pfam01553   1 RIEVHGLENLPrGGPAIVVANHQSYLDVLLLSLAL--YKRGRPLVFVAKKELFDIPLVGWLMRLLGCIFIDRKNRKDAAG 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2775958808 144 FEDMVDYfcAIHEPLQLLIFPEGTdltennkaRSNdfaeknglqkyEYVLHPRTTGFTFVVDRLRerrnldaVHDITVAY 223
Cdd:pfam01553  79 TLEYLVE--LLREGKLVVIFPEGT--------RSR-----------EGELLPFKKGAFRLAIEAG-------VPIVPVAI 130
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 31-167 1.86e-13

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 68.88  E-value: 1.86e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2775958808  31 LMFINLSWYRWISSRLVAMWLTLpvalletmFGVKVVITGDAFVPGERSVIIM-NHRTRVDWMFLWNCLMRY-SYLrlek 108
Cdd:COG0204     4 LFLLLRRFRYRLVRLWARLLLRL--------LGVRVRVEGLENLPADGPVLIVaNHQSWLDILLLLAALPRPvRFV---- 71

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2775958808 109 icLKSSLKSVPGFGWAMQVAAFIFIHR-KWKDDKSHFEDMVDyfcAIHEPLQLLIFPEGT 167
Cdd:COG0204    72 --AKKELFKIPLLGWLLRALGAIPVDRsKRRAALRALRQAVE---ALKAGESLVIFPEGT 126
LPLAT_AGPAT-like cd07989
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; ...
 61-167 3.92e-11

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.


Pssm-ID: 153251 [Multi-domain]  Cd Length: 184  Bit Score: 61.52  E-value: 3.92e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2775958808  61 MFGVKVVITGDAFVPGERSVIIM-NHRTRVDWMFLWNCLMRY-SYLrlekicLKSSLKSVPGFGWAMQVAAFIFIHR-KW 137
Cdd:cd07989     7 LLGVRVRVEGLENLPPKGPVIIVaNHQSYLDPLVLGAALPRPiRFV------AKKELFKIPFLGWLLRLLGAIPIDRgNG 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 2775958808 138 KDDKSHFEDMVDyfcAIHEPLQLLIFPEGT 167
Cdd:cd07989    81 RSAREALREAIE---ALKEGESVVIFPEGT 107
PRK14014 PRK14014
putative acyltransferase; Provisional
 8-286 1.30e-09

putative acyltransferase; Provisional


Pssm-ID: 237584 [Multi-domain]  Cd Length: 301  Bit Score: 58.71  E-value: 1.30e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2775958808   8 YFILFLFAGSFFG--SIFMLGPILPLMFINL-----SWYRWISSRLVAM---WLTLPVALLETMFGVKVVITGDA-FVPG 76
Cdd:PRK14014    7 APLRGLLSILLLIlnTLFWSVPIIILGLLKLllpipAIRRACSRLLNFIaeaWISINNVILRLLPRTQWDVEGLEgLSKK 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2775958808  77 ERSVIIMNHRTRVDWMFLwnclMRYSYLR--LEKICLKSSLKSVP--GFG-WAMQvaaFIFIHR------------KWKD 139
Cdd:PRK14014   87 GWYLVISNHQSWVDILVL----QYVFNRRipMLKFFLKQELIWVPflGLAwWALD---FPFMKRyskaylaknpelKGKD 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2775958808 140 ----DKShfedmvdyfCAI--HEPLQLLIFPEGTDLTENNKARSNdfaeknglQKYEYVLHPRTTGFTFVVDRLRERrnL 213
Cdd:PRK14014  160 lettRRA---------CEKfkRMPTTIVNFVEGTRFTPEKHQQQQ--------SPYQHLLKPKAGGIAFALNAMGEQ--F 220

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2775958808 214 DAVHDITVAYPYNIPqTEKHLLLGDfPKEIHFHVHRYPVDTL--------PTSKEDLQLWCHKRWEEKEERLRSFYQGEK 285
Cdd:PRK14014  221 DGLLDVTIVYPDGRP-SFWDLLSGR-VKKIVVHVRLLPIPEEligdyfndKEFRRRFQQWLNQLWQEKDQLIEQLLAQYN 298


                  .
gi 2775958808 286 N 286
Cdd:PRK14014  299 Q 299
AGP_acyltrn TIGR00530
1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous ...
 63-167 7.54e-07

1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous region of a collection of related proteins, several of which are known to act as 1-acyl-sn-glycerol-3-phosphate acyltransferases (EC 2.3.1.51). Proteins scoring above the trusted cutoff are likely to have the same general activity. However, there is variation among characterized members as to whether the acyl group can be donated by acyl carrier protein or coenzyme A, and in the length and saturation of the donated acyl group. 1-acyl-sn-glycerol-3-phosphate acyltransferase is also called 1-AGP acyltransferase, lysophosphatidic acid acyltransferase, and LPA acyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 129621 [Multi-domain]  Cd Length: 130  Bit Score: 47.73  E-value: 7.54e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2775958808  63 GVKVVITGDAFVPGERSVIIM-NHRTRVDwMFLWNCLMRYSYLRLEKIclksSLKSVPGFGWAMQVAAFIFIHRkwKDDK 141
Cdd:TIGR00530   1 GLKVEVVGPENLPAKSPVLVVaNHQSNLD-PLTLSAAFPPPIVFIAKK----ELKWIPFFGIMLWLTGAIFIDR--ENIR 73

                          90       100
                  ....*....|....*....|....*.
gi 2775958808 142 SHFEDMVDYFCAIHEPLQLLIFPEGT 167
Cdd:TIGR00530  74 AIATALKAAIEVLKQGRSIGVFPEGT 99
LPLAT_LPCAT1-like cd07991
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like; ...
 80-175 7.98e-04

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as lysophosphatidylcholine acyltransferase 1 (LPCAT-1), glycerol-3-phosphate acyltransferase 3 (GPAT3), and similar sequences.


Pssm-ID: 153253 [Multi-domain]  Cd Length: 211  Bit Score: 40.28  E-value: 7.98e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2775958808  80 VIIMNHRTRVDWMFLWNCLMrYSYLRlekiclKSSLKSVPGFGWAMQVAAFIFIHRKWKDD--------KSHFEDMvdyf 151
Cdd:cd07991    27 IIVANHTSFIDPLILFSDLF-PSIVA------KKELGKLPFIGTILRALGCIFVDRSEPKDrkkvveeiKERATDP---- 95

                          90       100
                  ....*....|....*....|....
gi 2775958808 152 caihEPLQLLIFPEGTdlTENNKA 175
Cdd:cd07991    96 ----NWPPILIFPEGT--TTNGKA 113
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH