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Conserved domains on  [gi|2772229914|ref|NP_001418622|]
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kelch-like protein 23 isoform a [Rattus norvegicus]

Protein Classification

kelch-like protein; BTB/POZ domain-containing protein 16( domain architecture ID 13033142)

kelch-like protein may act as substrate adaptors for Cullin 3 ubiquitin ligases| BTB/POZ domain-containing protein 16 (BTBD16) is a BTB-domain-containing Kelch-like protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BTB_POZ_KLHL23 cd18252
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-141 3.95e-90

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 23 (KLHL23); KLHL23 overexpression is associated with increased cell proliferation and invasion in gastric cancer. Downregulation of KLHL23 is associated with invasion, metastasis, and poor prognosis of hepatocellular carcinoma and pancreatic cancer. KLHL23 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


:

Pssm-ID: 349561 [Multi-domain]  Cd Length: 127  Bit Score: 272.85  E-value: 3.95e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  15 DSSHPVDFLDAFRTFYMDGLFTDITLQCPSGIIFHCHRAVLAACSNYFKAMFTADMKEKFKSKIKLSGIHHDILEGLVNY 94
Cdd:cd18252     1 DSSHPADFLDAFRTFYLDGLFTDITLQCASGQIFHCHKAALAACSSYFKVMFTADMKEKSNNVIKLSGIDHDILEALVNY 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 2772229914  95 AYTSQIEITKRNVQSLLEAADLLQFLSVKKACEQFLVRHLDIDNCIG 141
Cdd:cd18252    81 VYTSQICITERNVQSLLEAADLLQFISVKKACEQFLVRHLDIDNCLG 127
BACK_KLHL23 cd18462
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 23 (KLHL23); KLHL23 is ...
 134-235 2.79e-61

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 23 (KLHL23); KLHL23 is involved in tumorigenesis and resistance to anticancer drug treatment. It also associates with cone-rod dystrophy.


:

Pssm-ID: 350537 [Multi-domain]  Cd Length: 102  Bit Score: 197.26  E-value: 2.79e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914 134 LDIDNCIGMHSFAEFHVCSELEKESRRILCSRFKEVWQQEEFLEISLEKFLFILSRKNLSVWKEEAILEPVIKWTAHDVE 213
Cdd:cd18462     1 LDIDNCLGMHSFAEFHVCPELEKESRRIILSRFEEVWQQEEFLELSKEKLLYILSRENLNVWKEEVLIEAVVKWVAHDVE 80

                          90       100
                  ....*....|....*....|..
gi 2772229914 214 NRVECLYNLLSYVNIDIDPVYL 235
Cdd:cd18462    81 KRIECAYDLLSSIKLDLDEIYL 102
PHA03098 super family cl33709
kelch-like protein; Provisional
 45-545 1.89e-59

kelch-like protein; Provisional


The actual alignment was detected with superfamily member PHA03098:

Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 206.16  E-value: 1.89e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  45 GIIFHCHRAVLAACSNYFKAMFTADMKEKfksKIKLSgIHHDILEGLVNYAYTSQIEITKRNVQSLLEAADLLQFLSVKK 124
Cdd:PHA03098   20 GGIIKVHKIILSSSSEYFKKMFKNNFKEN---EINLN-IDYDSFNEVIKYIYTGKINITSNNVKDILSIANYLIIDFLIN 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914 125 ACEQFLVRHLDIDNCIGMHSFAEFHVCSELEKESRRILCSRFKEVWQQEEFLEISLEKFLFILSRKNLSVWKEEAILEPV 204
Cdd:PHA03098   96 LCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDFIYLSKNELIKILSDDKLNVSSEDVVLEII 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914 205 IKWTAHDVENRVECLYNLL-----SYVNIDIDPVYLKTALGLQRSCLLTENKIRSLIYNALNPMHKEISQRSTATMYI-I 278
Cdd:PHA03098  176 IKWLTSKKNNKYKDICLILkvlriTFLSEEGIKKLKRWKLRIKKKKIVFNKRCIKIIYSKKYNLNKILPRSSTFGSIIyI 255

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914 279 GGYYWHPLSEVHIWDPLTNVWIQGAEIPDytRESYGVTCLGPNIYVTGGYRTDNiDALDTVWIYNSEGDEWTEGLPMLNA 358
Cdd:PHA03098  256 HITMSIFTYNYITNYSPLSEINTIIDIHY--VYCFGSVVLNNVIYFIGGMNKNN-LSVNSVVSYDTKTKSWNKVPELIYP 332

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914 359 RYYHCAVTLGGCVYALGGYRKGAPAEEAEFYDPLKEKWLPIANMIKGVGNATACVLHEVIYVIGGhcGYRGSCTYDKVQS 438
Cdd:PHA03098  333 RKNPGVTVFNNRIYVIGGIYNSISLNTVESWKPGESKWREEPPLIFPRYNPCVVNVNNLIYVIGG--ISKNDELLKTVEC 410

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914 439 YNSDINEWSLITASPHPEYGLCSVPFENKLYLVGGQTTIT--------ECYDPEQNEWRETAPMMERRMECGAVIMNGCI 510
Cdd:PHA03098  411 FSLNTNKWSKGSPLPISHYGGCAIYHDGKIYVIGGISYIDnikvynivESYNPVTNKWTELSSLNFPRINASLCIFNNKI 490

                         490       500       510
                  ....*....|....*....|....*....|....*
gi 2772229914 511 YVTGGYSYSKgtYLQSIEKYDPDLNKWEIVGNLPS 545
Cdd:PHA03098  491 YVVGGDKYEY--YINEIEVYDDKTNTWTLFCKFPK 523
 
Name Accession Description Interval E-value
BTB_POZ_KLHL23 cd18252
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-141 3.95e-90

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 23 (KLHL23); KLHL23 overexpression is associated with increased cell proliferation and invasion in gastric cancer. Downregulation of KLHL23 is associated with invasion, metastasis, and poor prognosis of hepatocellular carcinoma and pancreatic cancer. KLHL23 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349561 [Multi-domain]  Cd Length: 127  Bit Score: 272.85  E-value: 3.95e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  15 DSSHPVDFLDAFRTFYMDGLFTDITLQCPSGIIFHCHRAVLAACSNYFKAMFTADMKEKFKSKIKLSGIHHDILEGLVNY 94
Cdd:cd18252     1 DSSHPADFLDAFRTFYLDGLFTDITLQCASGQIFHCHKAALAACSSYFKVMFTADMKEKSNNVIKLSGIDHDILEALVNY 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 2772229914  95 AYTSQIEITKRNVQSLLEAADLLQFLSVKKACEQFLVRHLDIDNCIG 141
Cdd:cd18252    81 VYTSQICITERNVQSLLEAADLLQFISVKKACEQFLVRHLDIDNCLG 127
BACK_KLHL23 cd18462
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 23 (KLHL23); KLHL23 is ...
 134-235 2.79e-61

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 23 (KLHL23); KLHL23 is involved in tumorigenesis and resistance to anticancer drug treatment. It also associates with cone-rod dystrophy.


Pssm-ID: 350537 [Multi-domain]  Cd Length: 102  Bit Score: 197.26  E-value: 2.79e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914 134 LDIDNCIGMHSFAEFHVCSELEKESRRILCSRFKEVWQQEEFLEISLEKFLFILSRKNLSVWKEEAILEPVIKWTAHDVE 213
Cdd:cd18462     1 LDIDNCLGMHSFAEFHVCPELEKESRRIILSRFEEVWQQEEFLELSKEKLLYILSRENLNVWKEEVLIEAVVKWVAHDVE 80

                          90       100
                  ....*....|....*....|..
gi 2772229914 214 NRVECLYNLLSYVNIDIDPVYL 235
Cdd:cd18462    81 KRIECAYDLLSSIKLDLDEIYL 102
PHA03098 PHA03098
kelch-like protein; Provisional
 45-545 1.89e-59

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 206.16  E-value: 1.89e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  45 GIIFHCHRAVLAACSNYFKAMFTADMKEKfksKIKLSgIHHDILEGLVNYAYTSQIEITKRNVQSLLEAADLLQFLSVKK 124
Cdd:PHA03098   20 GGIIKVHKIILSSSSEYFKKMFKNNFKEN---EINLN-IDYDSFNEVIKYIYTGKINITSNNVKDILSIANYLIIDFLIN 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914 125 ACEQFLVRHLDIDNCIGMHSFAEFHVCSELEKESRRILCSRFKEVWQQEEFLEISLEKFLFILSRKNLSVWKEEAILEPV 204
Cdd:PHA03098   96 LCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDFIYLSKNELIKILSDDKLNVSSEDVVLEII 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914 205 IKWTAHDVENRVECLYNLL-----SYVNIDIDPVYLKTALGLQRSCLLTENKIRSLIYNALNPMHKEISQRSTATMYI-I 278
Cdd:PHA03098  176 IKWLTSKKNNKYKDICLILkvlriTFLSEEGIKKLKRWKLRIKKKKIVFNKRCIKIIYSKKYNLNKILPRSSTFGSIIyI 255

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914 279 GGYYWHPLSEVHIWDPLTNVWIQGAEIPDytRESYGVTCLGPNIYVTGGYRTDNiDALDTVWIYNSEGDEWTEGLPMLNA 358
Cdd:PHA03098  256 HITMSIFTYNYITNYSPLSEINTIIDIHY--VYCFGSVVLNNVIYFIGGMNKNN-LSVNSVVSYDTKTKSWNKVPELIYP 332

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914 359 RYYHCAVTLGGCVYALGGYRKGAPAEEAEFYDPLKEKWLPIANMIKGVGNATACVLHEVIYVIGGhcGYRGSCTYDKVQS 438
Cdd:PHA03098  333 RKNPGVTVFNNRIYVIGGIYNSISLNTVESWKPGESKWREEPPLIFPRYNPCVVNVNNLIYVIGG--ISKNDELLKTVEC 410

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914 439 YNSDINEWSLITASPHPEYGLCSVPFENKLYLVGGQTTIT--------ECYDPEQNEWRETAPMMERRMECGAVIMNGCI 510
Cdd:PHA03098  411 FSLNTNKWSKGSPLPISHYGGCAIYHDGKIYVIGGISYIDnikvynivESYNPVTNKWTELSSLNFPRINASLCIFNNKI 490

                         490       500       510
                  ....*....|....*....|....*....|....*
gi 2772229914 511 YVTGGYSYSKgtYLQSIEKYDPDLNKWEIVGNLPS 545
Cdd:PHA03098  491 YVVGGDKYEY--YINEIEVYDDKTNTWTLFCKFPK 523
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
299-553 7.15e-48

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 168.03  E-value: 7.15e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914 299 WIQGAEIPDYTRESYGVTcLGPNIYVTGGYRTDniDALDTVWIYNSEGDEWTEGLPM-LNARYYHCAVTLGGCVYALGGY 377
Cdd:COG3055     3 WSSLPDLPTPRSEAAAAL-LDGKVYVAGGLSGG--SASNSFEVYDPATNTWSELAPLpGPPRHHAAAVAQDGKLYVFGGF 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914 378 RKGAPAEE----AEFYDPLKEKWLPIANMIKGVGNATACVLHEVIYVIGGhcgYRGSCTYDKVQSYNSDINEWSLITASP 453
Cdd:COG3055    80 TGANPSSTplndVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGG---WDDGGNVAWVEVYDPATGTWTQLAPLP 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914 454 HPEYGLCSVPF-ENKLYLVGGQTtitecYDPEQNEWRETAPMMERRMECGAVIMNGCIYVTGGYSyskgTYLQSIEKYDP 532
Cdd:COG3055   157 TPRDHLAAAVLpDGKILVIGGRN-----GSGFSNTWTTLAPLPTARAGHAAAVLGGKILVFGGES----GFSDEVEAYDP 227

                         250       260
                  ....*....|....*....|.
gi 2772229914 533 DLNKWEIVGNLPSAMRSHGCV 553
Cdd:COG3055   228 ATNTWTALGELPTPRHGHAAV 248
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 139-239 2.71e-31

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 116.88  E-value: 2.71e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914 139 CIGMHSFAEFHVCSELEKESRRILCSRFKEVWQQEEFLEISLEKFLFILSRKNLSVWKEEAILEPVIKWTAHDVENRVEC 218
Cdd:pfam07707   1 CLGIYRFADAYGCTELAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLNVPSEEEVFEAVIRWVKHDVERRKKH 80

                          90       100
                  ....*....|....*....|..
gi 2772229914 219 LYNLLSYVNID-IDPVYLKTAL 239
Cdd:pfam07707  81 LPELLSAVRLPlLSPQYLLNLV 102
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 33-134 1.09e-29

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 112.74  E-value: 1.09e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  33 GLFTDITLQCpSGIIFHCHRAVLAACSNYFKAMFTADMKEKFKSKIKLSGIHHDILEGLVNYAYTSQIeITKRNVQSLLE 112
Cdd:pfam00651   8 GELCDVTLVV-GDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDDVSPEDFEALLEFMYTGKL-ISEENVDDLLA 85

                          90       100
                  ....*....|....*....|..
gi 2772229914 113 AADLLQFLSVKKACEQFLVRHL 134
Cdd:pfam00651  86 AADKLQIPSLVDKCEEFLIKSL 107
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 37-134 1.89e-26

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 103.15  E-value: 1.89e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914   37 DITLQCpSGIIFHCHRAVLAACSNYFKAMFTADMKEKFKSKIKLSGIHHDILEGLVNYAYTSQIEITKRNVQSLLEAADL 116
Cdd:smart00225   1 DVTLVV-GGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADY 79

                           90
                   ....*....|....*...
gi 2772229914  117 LQFLSVKKACEQFLVRHL 134
Cdd:smart00225  80 LQIPGLVELCEEFLLKLL 97
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 139-236 6.89e-25

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 98.95  E-value: 6.89e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  139 CIGMHSFAEFHVCSELEKESRRILCSRFKEVWQQEEFLEISLEKFLFILSRKNLSVWKEEAILEPVIKWTAHDVENRVEC 218
Cdd:smart00875   1 CLGIRRFADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVSSEEEVFEAVLRWVKHDPEKRREH 80

                           90
                   ....*....|....*....
gi 2772229914  219 LYNLLSYVNID-IDPVYLK 236
Cdd:smart00875  81 LPELLEHVRLPlLSPDYLL 99
Kelch smart00612
Kelch domain;
509-557 5.79e-12

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 60.26  E-value: 5.79e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 2772229914  509 CIYVTGGYSYskGTYLQSIEKYDPDLNKWEIVGNLPSAmRSHGCVCVYN 557
Cdd:smart00612   1 KIYVVGGFDG--GQRLKSVEVYDPETNKWTPLPSMPTP-RSGHGVAVIN 46
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 497-544 3.36e-09

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 52.61  E-value: 3.36e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 2772229914 497 RRMECGAVIMNGCIYVTGGYSysKGTYLQSIEKYDPDLNKWEIVGNLP 544
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFD--GNQSLNSVEVYDPETNTWSKLPSMP 46
 
Name Accession Description Interval E-value
BTB_POZ_KLHL23 cd18252
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-141 3.95e-90

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 23 (KLHL23); KLHL23 overexpression is associated with increased cell proliferation and invasion in gastric cancer. Downregulation of KLHL23 is associated with invasion, metastasis, and poor prognosis of hepatocellular carcinoma and pancreatic cancer. KLHL23 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349561 [Multi-domain]  Cd Length: 127  Bit Score: 272.85  E-value: 3.95e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  15 DSSHPVDFLDAFRTFYMDGLFTDITLQCPSGIIFHCHRAVLAACSNYFKAMFTADMKEKFKSKIKLSGIHHDILEGLVNY 94
Cdd:cd18252     1 DSSHPADFLDAFRTFYLDGLFTDITLQCASGQIFHCHKAALAACSSYFKVMFTADMKEKSNNVIKLSGIDHDILEALVNY 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 2772229914  95 AYTSQIEITKRNVQSLLEAADLLQFLSVKKACEQFLVRHLDIDNCIG 141
Cdd:cd18252    81 VYTSQICITERNVQSLLEAADLLQFISVKKACEQFLVRHLDIDNCLG 127
BACK_KLHL23 cd18462
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 23 (KLHL23); KLHL23 is ...
 134-235 2.79e-61

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 23 (KLHL23); KLHL23 is involved in tumorigenesis and resistance to anticancer drug treatment. It also associates with cone-rod dystrophy.


Pssm-ID: 350537 [Multi-domain]  Cd Length: 102  Bit Score: 197.26  E-value: 2.79e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914 134 LDIDNCIGMHSFAEFHVCSELEKESRRILCSRFKEVWQQEEFLEISLEKFLFILSRKNLSVWKEEAILEPVIKWTAHDVE 213
Cdd:cd18462     1 LDIDNCLGMHSFAEFHVCPELEKESRRIILSRFEEVWQQEEFLELSKEKLLYILSRENLNVWKEEVLIEAVVKWVAHDVE 80

                          90       100
                  ....*....|....*....|..
gi 2772229914 214 NRVECLYNLLSYVNIDIDPVYL 235
Cdd:cd18462    81 KRIECAYDLLSSIKLDLDEIYL 102
PHA03098 PHA03098
kelch-like protein; Provisional
 45-545 1.89e-59

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 206.16  E-value: 1.89e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  45 GIIFHCHRAVLAACSNYFKAMFTADMKEKfksKIKLSgIHHDILEGLVNYAYTSQIEITKRNVQSLLEAADLLQFLSVKK 124
Cdd:PHA03098   20 GGIIKVHKIILSSSSEYFKKMFKNNFKEN---EINLN-IDYDSFNEVIKYIYTGKINITSNNVKDILSIANYLIIDFLIN 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914 125 ACEQFLVRHLDIDNCIGMHSFAEFHVCSELEKESRRILCSRFKEVWQQEEFLEISLEKFLFILSRKNLSVWKEEAILEPV 204
Cdd:PHA03098   96 LCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDFIYLSKNELIKILSDDKLNVSSEDVVLEII 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914 205 IKWTAHDVENRVECLYNLL-----SYVNIDIDPVYLKTALGLQRSCLLTENKIRSLIYNALNPMHKEISQRSTATMYI-I 278
Cdd:PHA03098  176 IKWLTSKKNNKYKDICLILkvlriTFLSEEGIKKLKRWKLRIKKKKIVFNKRCIKIIYSKKYNLNKILPRSSTFGSIIyI 255

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914 279 GGYYWHPLSEVHIWDPLTNVWIQGAEIPDytRESYGVTCLGPNIYVTGGYRTDNiDALDTVWIYNSEGDEWTEGLPMLNA 358
Cdd:PHA03098  256 HITMSIFTYNYITNYSPLSEINTIIDIHY--VYCFGSVVLNNVIYFIGGMNKNN-LSVNSVVSYDTKTKSWNKVPELIYP 332

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914 359 RYYHCAVTLGGCVYALGGYRKGAPAEEAEFYDPLKEKWLPIANMIKGVGNATACVLHEVIYVIGGhcGYRGSCTYDKVQS 438
Cdd:PHA03098  333 RKNPGVTVFNNRIYVIGGIYNSISLNTVESWKPGESKWREEPPLIFPRYNPCVVNVNNLIYVIGG--ISKNDELLKTVEC 410

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914 439 YNSDINEWSLITASPHPEYGLCSVPFENKLYLVGGQTTIT--------ECYDPEQNEWRETAPMMERRMECGAVIMNGCI 510
Cdd:PHA03098  411 FSLNTNKWSKGSPLPISHYGGCAIYHDGKIYVIGGISYIDnikvynivESYNPVTNKWTELSSLNFPRINASLCIFNNKI 490

                         490       500       510
                  ....*....|....*....|....*....|....*
gi 2772229914 511 YVTGGYSYSKgtYLQSIEKYDPDLNKWEIVGNLPS 545
Cdd:PHA03098  491 YVVGGDKYEY--YINEIEVYDDKTNTWTLFCKFPK 523
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
299-553 7.15e-48

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 168.03  E-value: 7.15e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914 299 WIQGAEIPDYTRESYGVTcLGPNIYVTGGYRTDniDALDTVWIYNSEGDEWTEGLPM-LNARYYHCAVTLGGCVYALGGY 377
Cdd:COG3055     3 WSSLPDLPTPRSEAAAAL-LDGKVYVAGGLSGG--SASNSFEVYDPATNTWSELAPLpGPPRHHAAAVAQDGKLYVFGGF 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914 378 RKGAPAEE----AEFYDPLKEKWLPIANMIKGVGNATACVLHEVIYVIGGhcgYRGSCTYDKVQSYNSDINEWSLITASP 453
Cdd:COG3055    80 TGANPSSTplndVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGG---WDDGGNVAWVEVYDPATGTWTQLAPLP 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914 454 HPEYGLCSVPF-ENKLYLVGGQTtitecYDPEQNEWRETAPMMERRMECGAVIMNGCIYVTGGYSyskgTYLQSIEKYDP 532
Cdd:COG3055   157 TPRDHLAAAVLpDGKILVIGGRN-----GSGFSNTWTTLAPLPTARAGHAAAVLGGKILVFGGES----GFSDEVEAYDP 227

                         250       260
                  ....*....|....*....|.
gi 2772229914 533 DLNKWEIVGNLPSAMRSHGCV 553
Cdd:COG3055   228 ATNTWTALGELPTPRHGHAAV 248
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
274-531 7.04e-42

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 151.85  E-value: 7.04e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914 274 TMYIIGGY-YWHPLSEVHIWDPLTNVWIQGAEIPDYTRESYGVTCLGPNIYVTGGYRTDNID--ALDTVWIYNSEGDEWT 350
Cdd:COG3055    24 KVYVAGGLsGGSASNSFEVYDPATNTWSELAPLPGPPRHHAAAVAQDGKLYVFGGFTGANPSstPLNDVYVYDPATNTWT 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914 351 EGLPMLNARYYHCAVTLGGCVYALGGYRKGAPAEEAEFYDPLKEKWLPIANMIKGVGNATACVLHE-VIYVIGGhcgyrg 429
Cdd:COG3055   104 KLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPTPRDHLAAAVLPDgKILVIGG------ 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914 430 sctydkvQSYNSDINEWSLITASPHPEYGLCSVPFENKLYLVGGQTTI---TECYDPEQNEWRETAPMMERRMECGAVIM 506
Cdd:COG3055   178 -------RNGSGFSNTWTTLAPLPTARAGHAAAVLGGKILVFGGESGFsdeVEAYDPATNTWTALGELPTPRHGHAAVLT 250

                         250       260
                  ....*....|....*....|....*...
gi 2772229914 507 NGCIYVTGGYSySKG---TYLQSIEKYD 531
Cdd:COG3055   251 DGKVYVIGGET-KPGvrtPLVTSAEVYD 277
BTB_POZ_KLHL8 cd18238
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-141 2.25e-36

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349547 [Multi-domain]  Cd Length: 120  Bit Score: 131.26  E-value: 2.25e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  21 DFLDAFRTFYMDGLFTDITLQCPSGIIfHCHRAVLAACSNYFKAMFTADMKEKFKSKIKLSGIHHDILEGLVNYAYTSQI 100
Cdd:cd18238     1 DSFKVLHQFYENGELCDVTLKVGEKSI-HCHRLVLACVSPYFRAMFTSEMAESKQDSITIKDIDEEAVELLVDFAYTGKL 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2772229914 101 EITKRNVQSLLEAADLLQFLSVKKACEQFLVRHLDIDNCIG 141
Cdd:cd18238    80 TLTVDNVQSLLYAASLLQVEEVAKACCEFMKDHLHPSNCLG 120
BTB_POZ_KLHL21 cd18250
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-139 3.29e-36

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349559 [Multi-domain]  Cd Length: 124  Bit Score: 131.04  E-value: 3.29e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  15 DSSHPVDFLDAFRTFYMDGLFTDITLqCPSGIIFHCHRAVLAACSNYFKAMFTADMKEKFKSKIKLSGIHHDILEGLVNY 94
Cdd:cd18250     1 DPAHALHLLRGLSELRAERKFFDVTL-CAGGREFPCHRTVLAAASSYFRAMFAGELRESRADRVVLHGVSAEILGLLLDF 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2772229914  95 AYTSQIEITKRNVQSLLEAADLLQFLSVKKACEQFLVRHLDIDNC 139
Cdd:cd18250    80 SYTGRVTVTQDNVEALLRAADLFQFPSVKEACCAYLQQRLDVSNC 124
BTB_POZ_KLHL6 cd18236
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 12-141 8.08e-34

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349545 [Multi-domain]  Cd Length: 129  Bit Score: 124.96  E-value: 8.08e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  12 LFKDSSHPVDFLDAFRTFYMDGLFTDITLqCPSGIIFHCHRAVLAACSNYFKAMFTADMKEKFKSKIKLSGIHHDILEGL 91
Cdd:cd18236     1 KFDDTGLSLVLQNGLENLRLENSLTDVIL-CVDSQEFSCHRVVLAAASNYFRAMFCNDLKEKYEEKIIIKGVDAETMQIL 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 2772229914  92 VNYAYTSQIEITKRNVQSLLEAADLLQFLSVKKACEQFLVRHLDIDNCIG 141
Cdd:cd18236    80 LDYTYTSKVLITKQNVQRVLEAASLFQFLRMVDACASFLTEALHPENCVG 129
BTB_POZ_KLHL12_C3IP1_DKIR cd18242
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 17-139 1.19e-33

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349551 [Multi-domain]  Cd Length: 124  Bit Score: 124.09  E-value: 1.19e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  17 SHPVDFLDAFRTFYMDGLFTDITLQCpSGIIFHCHRAVLAACSNYFKAMFTADMKEKFKSKIKLSGIHHDILEGLVNYAY 96
Cdd:cd18242     3 SHAKSILNTMNSLRKSNTLCDVTLRV-EGKEFPAHRIVLAACSDYFCAMFTSEMSEKGKSEVELQGLTASTMEILLDFVY 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 2772229914  97 TSQIEITKRNVQSLLEAADLLQFLSVKKACEQFLVRHLDIDNC 139
Cdd:cd18242    82 TETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQLDPSNC 124
BTB_POZ_KLHL37_ENC1 cd18267
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 10-142 1.91e-33

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ectoderm-neural cortex protein 1 (ENC-1); ENC-1 is also called Kelch-like protein 37 (KLHL37), nuclear matrix protein NRP/B, or p53-induced gene 10 protein. It is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349576 [Multi-domain]  Cd Length: 147  Bit Score: 124.33  E-value: 1.91e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  10 IYLFKDSSHPVDFLDAFRTFYMDGLFTDITLQCPSGIiFHCHRAVLAACSNYFKAMFTADMKEKFKSKIKL-SGIHHDIL 88
Cdd:cd18267    15 IYLFHKSSYADSVLTHLNLLRQQRLFTDVLLHAGNRS-FPCHRAVLAACSRYFEAMFSGGLKESQDSEVNFhDSIHPEVL 93

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2772229914  89 EGLVNYAYTSQIEITKRNVQSLLEAADLLQFLSVKKACEQFLVRHLDIDNCIGM 142
Cdd:cd18267    94 ELLLDYAYSSRVIINEENAESLLEAGDMLEFQDIRDACAEFLEKNLHPTNCLGM 147
BTB_POZ_KLHL7 cd18237
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 16-141 8.16e-33

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349546 [Multi-domain]  Cd Length: 126  Bit Score: 121.83  E-value: 8.16e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  16 SSHPVDFLDAFRTFYMDGLFTDITLQCpSGIIFHCHRAVLAACSNYFKAMFTADMKEKFKSKIKLSGIHHDILEGLVNYA 95
Cdd:cd18237     2 AKLLADFMGVMNNMRKQKTLCDVILIV-EGREIKAHRVVLAAASHFFHLMFTSNMTESKSSEVELKDAEPDIIELLVEFA 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 2772229914  96 YTSQIEITKRNVQSLLEAADLLQFLSVKKACEQFLVRHLDIDNCIG 141
Cdd:cd18237    81 YTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQLDASNCLG 126
BTB_POZ_KBTBD6_7 cd18273
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 12-142 9.60e-33

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing proteins KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349582 [Multi-domain]  Cd Length: 142  Bit Score: 122.24  E-value: 9.60e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  12 LFKDSSHPVDFLDAFRTFYMDGLFTDITLQC-------PSGIIFHCHRAVLAACSNYFKAMFTADMKEKFKSKIKLSGIH 84
Cdd:cd18273     3 ELEDAAHARALLAQLKSFYDARLLTDVTIEVngpgsgpGSGRLFPCNRNVLAAASPYFKSMFTGGLYESKQETVTIHDVD 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2772229914  85 HDILEGLVNYAYTSQIEITKRNVQSLLEAADLLQFLSVKKACEQFLVRHLDIDNCIGM 142
Cdd:cd18273    83 SESMALIIDYCYTGRVTLSEANVQRLYAAANMLQLEYVREACASFLARRLDLSNCVGI 140
BTB_POZ_KLHL38 cd18268
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-142 1.85e-32

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 38 (KLHL38); KLHL38 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The KLHL38 gene is significantly up-regulated during diapause, a temporary arrest of development during early ontogeny. It may also function in preadipocyte differentiation in the chicken. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349577 [Multi-domain]  Cd Length: 129  Bit Score: 121.05  E-value: 1.85e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  13 FKDSSHPVDFLDAFRTFYMDGLFTDITLqCPSGIIFHCHRAVLAACSNYFKAMFTADMKEKFKSKIKLSGIHHDILEGLV 92
Cdd:cd18268     1 FKDQDLSSELLRQLNSLRQERILTDVIL-CTGDKEIPCHRNVLASSSPYFRAMFCNNFRESSQAKVDLKGIDSDVLDQIV 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 2772229914  93 NYAYTSQIEITKRNVQSLLEAADLLQFLSVKKACEQFLVRHLDIDNCIGM 142
Cdd:cd18268    80 DYVYTGEILITRDNVLPLMEAASMLQYPKLFEACSLYLQDQLTPENCLSM 129
BTB_POZ_KBTBD8 cd18274
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-142 2.11e-32

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralog TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349583 [Multi-domain]  Cd Length: 129  Bit Score: 120.86  E-value: 2.11e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  15 DSSHPVDFLDAFRTFYMDGLFTDITLQCPSGIIFHCHRAVLAACSNYFKAMFTADMKEKFKSKIKLSGIHHDILEGLVNY 94
Cdd:cd18274     2 DPLHACSILQQLKAMYDEGQLTDIVVEVDHGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMHLVLDY 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2772229914  95 AYTSQIEITKRNVQSLLEAADLLQFLSVKKACEQFLVRHLDIDNCIGM 142
Cdd:cd18274    82 AYTSRVTLTEANVQALFTAASIFQIPSLQDQCAQFMISRLDPQNSIGV 129
BTB_POZ_KLHL24_KRIP6 cd18253
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 18-139 6.87e-32

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349562 [Multi-domain]  Cd Length: 121  Bit Score: 119.17  E-value: 6.87e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  18 HPVDFLDAFRTFYMDGLFTDITLqCPSGIIFHCHRAVLAACSNYFKAMFTADMKEKFKSKIKLSGIHHDILEGLVNYAYT 97
Cdd:cd18253     1 HSESILQVFNEFRDSRLFTDVII-CVEGREFPCHRAILSACSSYFRAMFCNDHRESREMLVEINGILAEAMDCFLQYVYT 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 2772229914  98 SQIEITKRNVQSLLEAADLLQFLSVKKACEQFLVRHLDIDNC 139
Cdd:cd18253    80 GKVKITTENVQYLFETSSLFQISPLRDACAKFLEEQLDPCNC 121
BTB_POZ_KLHL27_IPP cd18256
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 35-141 7.40e-32

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349565 [Multi-domain]  Cd Length: 125  Bit Score: 119.05  E-value: 7.40e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  35 FTDITLQCpSGIIFHCHRAVLAACSNYFKAMFTADMKEKFKSKIKLSGIHHDILEGLVNYAYTSQIEITKRNVQSLLEAA 114
Cdd:cd18256    20 FCDVQLQV-GMELFSVHRLVLAASSPYFAALFAGGMSESSKDVVQIHGVEPDIFHILLDFIYTGVVEVTVSNVQELLVAA 98

                          90       100
                  ....*....|....*....|....*..
gi 2772229914 115 DLLQFLSVKKACEQFLVRHLDIDNCIG 141
Cdd:cd18256    99 DMLQLTEVVEICCEFLKGQLHPSNCIG 125
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 139-239 2.71e-31

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 116.88  E-value: 2.71e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914 139 CIGMHSFAEFHVCSELEKESRRILCSRFKEVWQQEEFLEISLEKFLFILSRKNLSVWKEEAILEPVIKWTAHDVENRVEC 218
Cdd:pfam07707   1 CLGIYRFADAYGCTELAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLNVPSEEEVFEAVIRWVKHDVERRKKH 80

                          90       100
                  ....*....|....*....|..
gi 2772229914 219 LYNLLSYVNID-IDPVYLKTAL 239
Cdd:pfam07707  81 LPELLSAVRLPlLSPQYLLNLV 102
BTB_POZ_KLHL30 cd18259
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 16-141 1.36e-30

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 30 (KLHL30); KLHL30 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349568 [Multi-domain]  Cd Length: 137  Bit Score: 116.08  E-value: 1.36e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  16 SSHPVDFLDAFRTFYMDGLFTDITLQCpSGIIFHCHRAVLAACSNYFKAMFTADMKEKFKSKIKLSGIHHDILEGLVNYA 95
Cdd:cd18259    13 PSHPQSILDGLQTLRSNPKLSDVTLLV-GGREFPCHRSVLALCSHYFNAMFTGDFVESISARVEIKDVDPAVMESLIDFA 91

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 2772229914  96 YTSQIEITKRNVQSLLEAADLLQFLSVKKACEQFLVRHLDIDNCIG 141
Cdd:cd18259    92 YTGKLTINQGNVEALIRTSNRLQFPTVRKVCSRYLQQQIDATNCLG 137
BTB_POZ_KLHL25 cd18254
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 17-141 6.37e-30

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that is required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). Cullin3-KLHL25 ubiquitin ligase also targets ATP-citrate lyase (ACLY), a key enzyme for lipid synthesis, for degradation to inhibit lipid synthesis and tumor progression. KLHL25 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349563 [Multi-domain]  Cd Length: 128  Bit Score: 113.95  E-value: 6.37e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  17 SHPVDFLDAFRTFYMDGLFTDITLQCPSGIiFHCHRAVLAACSNYFKAMFTADMKEKFKSKIKL-SGIHHDILEGLVNYA 95
Cdd:cd18254     4 SHPDCVLTHLNTLRKQCMFTDVTLWAGNRS-FPCHRAVLAACSRYFEAMFSNGLRESLDSTVNFhDSLHPEVLELLLDFA 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 2772229914  96 YTSQIEITKRNVQSLLEAADLLQFLSVKKACEQFLVRHLDIDNCIG 141
Cdd:cd18254    83 YSSRIIINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLYPSNCLG 128
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 33-134 1.09e-29

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 112.74  E-value: 1.09e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  33 GLFTDITLQCpSGIIFHCHRAVLAACSNYFKAMFTADMKEKFKSKIKLSGIHHDILEGLVNYAYTSQIeITKRNVQSLLE 112
Cdd:pfam00651   8 GELCDVTLVV-GDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDDVSPEDFEALLEFMYTGKL-ISEENVDDLLA 85

                          90       100
                  ....*....|....*....|..
gi 2772229914 113 AADLLQFLSVKKACEQFLVRHL 134
Cdd:pfam00651  86 AADKLQIPSLVDKCEEFLIKSL 107
BTB_POZ_ZBTB_KLHL-like cd18186
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 35-117 1.64e-29

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349497 [Multi-domain]  Cd Length: 82  Bit Score: 111.11  E-value: 1.64e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  35 FTDITLQCpSGIIFHCHRAVLAACSNYFKAMFTADMKEKFKSKIKLSGIHHDILEGLVNYAYTSQIEITKRNVQSLLEAA 114
Cdd:cd18186     1 LCDVTLVV-GGREFPAHRAVLAARSPYFRAMFSSGMKESSSSEIELDDVSPEAFEALLDYIYTGELELSEENVEELLAAA 79


                  ...
gi 2772229914 115 DLL 117
Cdd:cd18186    80 DKL 82
BTB_POZ_KLHL18 cd18247
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 26-130 2.04e-29

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349556 [Multi-domain]  Cd Length: 116  Bit Score: 111.99  E-value: 2.04e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  26 FRTFYMDGLFTDITLQCpSGIIFHCHRAVLAACSNYFKAMFTADMKEKFKSKIKLSGIHHDILEGLVNYAYTSQIEITKR 105
Cdd:cd18247    10 MEEIRRQGKLCDVTLKV-GDQKFSAHRIVLAATIPYFHAMFTHDMVESKQDEITMQGIEPSALEALINFAYSGRIAIDTS 88

                          90       100
                  ....*....|....*....|....*
gi 2772229914 106 NVQSLLEAADLLQFLSVKKACEQFL 130
Cdd:cd18247    89 NVQSLLVGASFLQLQSVKDACCEFL 113
BTB_POZ_KLHL26 cd18255
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-139 7.96e-29

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349564 [Multi-domain]  Cd Length: 121  Bit Score: 110.56  E-value: 7.96e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  23 LDAFRTfymDGLFTDITLQCpSGIIFHCHRAVLAACSNYFKAMFTADMKEKFKSKIKLSGIHHDILEGLVNYAYTSQIEI 102
Cdd:cd18255     9 LNALRA---KGQLLDVTLIA-DGQRFQAHKVVLASCSDYFRAMFTGGMRESSQDEIELKGVSAKGLKHILDFAYTSELTL 84

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2772229914 103 TKRNVQSLLEAADLLQFLSVKKACEQFLVRHLDIDNC 139
Cdd:cd18255    85 DLDCIQDVLGAAVHLQMLPVVELCEEFLKSAMSVENC 121
BTB_POZ_KLHL2-like cd18235
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 18-135 9.68e-29

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349544 [Multi-domain]  Cd Length: 121  Bit Score: 110.60  E-value: 9.68e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  18 HPVDFLDAFRTFYM---DGLFTDITLQCpSGIIFHCHRAVLAACSNYFKAMFTADMKEKFKSKIKLSGIHHDILEGLVNY 94
Cdd:cd18235     1 NPQHTQKAFDVMNElrkQNLLCDVILVA-DGVEIPAHRVVLASCSPYFHAMFTGDLSESRANRVTLQDVDGKALLLLIDY 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2772229914  95 AYTSQIEITKRNVQSLLEAADLLQFLSVKKACEQFLVRHLD 135
Cdd:cd18235    80 VYTAEIQVTEENVQVLLPAANLLQLTDVRDACCDFLQSQLH 120
BTB_POZ_KLHL1-like cd18234
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 51-140 6.85e-27

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This family contains the Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. Family members contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349543 [Multi-domain]  Cd Length: 105  Bit Score: 104.76  E-value: 6.85e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  51 HRAVLAACSNYFKAMFTADMKEKFKSKIKLSGIHHDILEGLVNYAYTSQIEITKRNVQSLLEAADLLQFLSVKKACEQFL 130
Cdd:cd18234    16 HRLVLSAVSDYFAAMFTNDVREATEEEIKLKDVDPDALWTLVQYCYTGRLELKEDNVESLLATACLLQLSEVVEACCGFL 95

                          90
                  ....*....|
gi 2772229914 131 VRHLDIDNCI 140
Cdd:cd18234    96 MKQLHPSNCL 105
BTB_POZ_KLHL19_KEAP1 cd18248
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-135 1.19e-26

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also called cytosolic inhibitor of Nrf2 (INrf2) or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349557 [Multi-domain]  Cd Length: 124  Bit Score: 104.77  E-value: 1.19e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  15 DSSHPVDfldAFRTFYM---DGLFTDITLQCPSGII---FHCHRAVLAACSNYFKAMFTADMKEKFKSKIKLSGIHHDIL 88
Cdd:cd18248     1 LEDHTKE---AFQIMNElrlSQQLCDVTLKVKYQDPkeeFMAHKVVLASSSPYFKAMFTSGLRECGMEVVPIEGVHPCVM 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 2772229914  89 EGLVNYAYTSQIEITKRNVQSLLEAADLLQFLSVKKACEQFLVRHLD 135
Cdd:cd18248    78 SRLIEFAYTASISVGEKCVLHVLPGAVMYQMDSVVKACCDFLEQQLD 124
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 37-134 1.89e-26

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 103.15  E-value: 1.89e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914   37 DITLQCpSGIIFHCHRAVLAACSNYFKAMFTADMKEKFKSKIKLSGIHHDILEGLVNYAYTSQIEITKRNVQSLLEAADL 116
Cdd:smart00225   1 DVTLVV-GGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADY 79

                           90
                   ....*....|....*...
gi 2772229914  117 LQFLSVKKACEQFLVRHL 134
Cdd:smart00225  80 LQIPGLVELCEEFLLKLL 97
BTB_POZ_KLHL10 cd18240
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-139 2.94e-26

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349549 [Multi-domain]  Cd Length: 120  Bit Score: 103.56  E-value: 2.94e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  23 LDAFRTFYMDGLFTDITLQCpSGIIFHCHRAVLAACSNYFKAMFTADMKEKFKSKIKLSGIHHDILEGLVNYAYTSQIEI 102
Cdd:cd18240     5 CNVFNELRLEGKLCDVVIRV-NGVEFPAHRNILCACSPYFRALFTNGWNETEKKVYKIPGVSPEMMELIIEYAYTRTVPI 83

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2772229914 103 TKRNVQSLLEAADLLQFLSVKKACEQFLVRHLDIDNC 139
Cdd:cd18240    84 TAENVEELLPAADQFNIMGIVKACCDFLEDQLCPENC 120
BTB_POZ_KLHL9_13 cd18239
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-139 4.69e-26

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13; KLHL9 and KLHL13 (also called BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes, thereby coordinating faithful mitotic progression and completion of cytokinesis. They contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349548 [Multi-domain]  Cd Length: 128  Bit Score: 103.35  E-value: 4.69e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  13 FKDSSHPVDFLDAFRTFYMDGLFTDITLQCPSGI-IFHCHRAVLAACSNYFKAMFTADMKEKFKSKIKLSGIHHDILEGL 91
Cdd:cd18239     1 FTSNTHSSVVLQGFDQLRGEGLLCDVTLVPGDGDeTFPVHRAMMASASDYFKAMFTGGMKEQELMCIKLHGVSKIGLKNI 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2772229914  92 VNYAYTSQIEITKRNVQSLLEAADLLQFLSVKKACEQFLVRHLDIDNC 139
Cdd:cd18239    81 IDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVLLISGVTLENC 128
BTB_POZ_KLHL28_BTBD5 cd18257
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 37-135 5.18e-26

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also called BTB/POZ domain-containing protein 5 (BTBD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349566 [Multi-domain]  Cd Length: 118  Bit Score: 102.62  E-value: 5.18e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  37 DITLQCpSGIIFHCHRAVLAACSNYFKAMFTADMKEKFKSKIKLSGIHHDILEGLVNYAYTSQIEITKRNVQSLLEAADL 116
Cdd:cd18257    20 DVVLRV-GDVKIHAHKVVLASCSPYFKAMFTGNLSEKENSEVEFQCIDETALQAIVEYAYTGTVFISQATVESLLPAANL 98

                          90
                  ....*....|....*....
gi 2772229914 117 LQFLSVKKACEQFLVRHLD 135
Cdd:cd18257    99 LQIKLVLKECCDFLESQLD 117
BTB_POZ_NS1BP cd18306
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 18-141 7.25e-26

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349615 [Multi-domain]  Cd Length: 124  Bit Score: 102.34  E-value: 7.25e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  18 HPVDFLDAFRTFYMDGLFTDITLQCpSGIIFHCHRAVLAACSNYFKAMFTADMKEKFKSKIKLSGIHHDILEGLVNYAYT 97
Cdd:cd18306     1 HPESVLAKLNALRKNRQFCDVILQV-GGHEIPAHRAVLACASPYLFELFSSDSDGESILTVKLDGLDPDAVEVLVNYAYT 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 2772229914  98 SQIEITKRNVQSLLEAADLLQFLSVKKACEQFLVRHLDIDNCIG 141
Cdd:cd18306    80 SRLEVPADLVKSVYSAAKKLKMDRVKKACGDFLLEKLTPQNCIG 123
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 139-236 6.89e-25

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 98.95  E-value: 6.89e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  139 CIGMHSFAEFHVCSELEKESRRILCSRFKEVWQQEEFLEISLEKFLFILSRKNLSVWKEEAILEPVIKWTAHDVENRVEC 218
Cdd:smart00875   1 CLGIRRFADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVSSEEEVFEAVLRWVKHDPEKRREH 80

                           90
                   ....*....|....*....
gi 2772229914  219 LYNLLSYVNID-IDPVYLK 236
Cdd:smart00875  81 LPELLEHVRLPlLSPDYLL 99
BTB_POZ_KLHL20_KLEIP cd18249
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 18-141 7.31e-25

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also called Kelch-like ECT2-interacting protein (KLEIP) or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349558 [Multi-domain]  Cd Length: 128  Bit Score: 99.83  E-value: 7.31e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  18 HPVDFLDAFRTFYMDGLFTDITLQCPSGIIFhCHRAVLAACSNYFKAMFTADMKEKFKSKIKLSGIHHDILEGLVNYAYT 97
Cdd:cd18249     6 HPRQTLEAINLLRKHRELCDVVLVVGAKKIY-AHRVILSACSPYFRAMFTGELAESRQTEVTIRDIDERAMELLIDFAYT 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 2772229914  98 SQIEITKRNVQSLLEAADLLQFLSVKKACEQFLVRHLDIDNCIG 141
Cdd:cd18249    85 SQITVEEGNVQTLLPAACLLQLAEIQEVCCEFLKRQLDPSNCLG 128
BTB_POZ_KLHL35 cd18265
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 16-141 1.22e-24

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349574 [Multi-domain]  Cd Length: 128  Bit Score: 99.08  E-value: 1.22e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  16 SSHPVDFLDAFRTFYMDGLFTDITLQCpSGIIFHCHRAVLAACSNYFKAMFTADMKEKFKSKIKLSGIHHDILEGLVNYA 95
Cdd:cd18265     4 PCHAERILQVLNAYRRSGTFTDVVLLV-DGKDFPCHRATLSANSAYFRAMFGGHLKESRQAVVEIQKVSAAAMEVLLDYM 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 2772229914  96 YTSQIEITKRNVQSLLEAADLLQFLSVKKACEQFLVRHLDIDNCIG 141
Cdd:cd18265    83 YGGGLRIQEDNVESVLEASDLLQVSKLREACVRFLEGQLHPCNCLG 128
BTB_POZ_KBTBD3_BKLHD3 cd18271
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 17-140 4.38e-24

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also called BTB and kelch domain-containing protein 3 (BKLHD3), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349580 [Multi-domain]  Cd Length: 130  Bit Score: 97.60  E-value: 4.38e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  17 SHPVDFLDAFRTFYMDGLFTDITLQCpSGIIFHCHRAVLAACSNYFKAMFTADMKEKFKSKIKLSGIHHDILEGLVNYAY 96
Cdd:cd18271     6 CHGQQILSVLQNFREQNAFFDFNIIV-KDETIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTISNLSPKAVKAFLDYAY 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 2772229914  97 TSQIEITKRNVQSLLEAADLLQFLSVKKACEQFLVRHLDIDNCI 140
Cdd:cd18271    85 TGKAEITDDNVEMFFQMSSFLQVSLLSKACSDFLIKSIDLTNCL 128
BTB_POZ_KLHL3 cd18339
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 34-134 7.26e-24

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 3 (KLHL3); KLHL3 is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349648 [Multi-domain]  Cd Length: 121  Bit Score: 96.71  E-value: 7.26e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  34 LFTDITLQCPSgIIFHCHRAVLAACSNYFKAMFTADMKEKFKSKIKLSGIHHDILEGLVNYAYTSQIEITKRNVQSLLEA 113
Cdd:cd18339    20 LLCDVTIVAED-VEIEAHRVVLAACSPYFCAMFTGDMSESKAKKIEIKDVDGQTLSKLIDYIYTAEIEVTEENVQVLLPA 98

                          90       100
                  ....*....|....*....|.
gi 2772229914 114 ADLLQFLSVKKACEQFLVRHL 134
Cdd:cd18339    99 ASLLQLMDVRQNCCDFLQSQL 119
BTB_POZ_KLHL40_KBTBD5 cd18340
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 48-142 9.18e-23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5 (KBTBD5) or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy. KLHL40 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349649 [Multi-domain]  Cd Length: 134  Bit Score: 94.13  E-value: 9.18e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  48 FHCHRAVLAACSNYFKAMFTADMKEKFKSKIKLSGIHHDILEGLVNYAYTSQIEITKRNVQSLLEAADLLQFLSVKKACE 127
Cdd:cd18340    39 FPCHRLVLAACSPYFRAMFLSDLEESKKREIVLEDVDPDVMGKILHYIYTSEIEITEQNVQDIFAAANMFQIPSIFTVCV 118

                          90
                  ....*....|....*
gi 2772229914 128 QFLVRHLDIDNCIGM 142
Cdd:cd18340   119 SFLQKRLCLSNCLAI 133
BTB_POZ_KBTBD2_BKLHD1 cd18270
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-142 1.91e-22

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulation of insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349579 [Multi-domain]  Cd Length: 133  Bit Score: 93.14  E-value: 1.91e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  15 DSSHPVDFLDAFRTFYMDGLFTDITLqCPSGIIFHCHRAVLAACSNYFKAMFTADMKEKFKSKIKLSGIHHDILEGLVNY 94
Cdd:cd18270     6 NTEYAVSLLEQLKFFYEQQLLTDIVL-IVEGTEFPCHKMVLATCSSYFRAMFMSGLSESKQTHVHLRNVDAATLQIIITY 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2772229914  95 AYTSQIEITKRNVQSLLEAADLLQFLSVKKACEQFLVRHLDIDNCIGM 142
Cdd:cd18270    85 AYTGNLAINDSTVEQLYETACFLQVEDVLQRCREYLIKKINAENCVRL 132
BTB_POZ_KLHL4 cd18336
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 51-142 7.51e-22

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It may be associated with X-linked cleft palate (CPX) and is also a candidate gene in the impairment of mullerian duct development. In addition, it has been identified as a target of insulin-like growth factor binding protein 5 (IGFBP5). KLHL4 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349645 [Multi-domain]  Cd Length: 126  Bit Score: 91.26  E-value: 7.51e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  51 HRAVLAACSNYFKAMFTADMKEKFKSKIKLSGIHHDILEGLVNYAYTSQIEITKRNVQSLLEAADLLQFLSVKKACEQFL 130
Cdd:cd18336    34 HRLVLSAVSDYFAAMFTNDVREAKQEEIKMEGVDPDALKALVHYAYTGVLELKEDTIESLLAAACLLQLSQVIDVCCNFL 113

                          90
                  ....*....|..
gi 2772229914 131 VRHLDIDNCIGM 142
Cdd:cd18336   114 MKQLHPSNCLGI 125
BTB_POZ_KLHL2_Mayven cd18338
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 51-134 7.65e-22

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349647 [Multi-domain]  Cd Length: 121  Bit Score: 90.90  E-value: 7.65e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  51 HRAVLAACSNYFKAMFTADMKEKFKSKIKLSGIHHDILEGLVNYAYTSQIEITKRNVQSLLEAADLLQFLSVKKACEQFL 130
Cdd:cd18338    36 HRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDGWTLKMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFL 115


                  ....
gi 2772229914 131 VRHL 134
Cdd:cd18338   116 ESQL 119
BTB_POZ_KLHL40-like cd18269
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 48-140 7.51e-21

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL40 and KLHL41; This family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349578 [Multi-domain]  Cd Length: 133  Bit Score: 88.62  E-value: 7.51e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  48 FHCHRAVLAACSNYFKAMFTADMKEKFKSKIKLSGIHHDILEGLVNYAYTSQIEITKRNVQSLLEAADLLQFLSVKKACE 127
Cdd:cd18269    39 FPCHRLVLAACSPYFRAMFLSDLEESKKKEVVLEDVDPDVMGMILKYLYTSEIDLNDQNVQDIFALASRFQIPSIFTVCV 118

                          90
                  ....*....|...
gi 2772229914 128 QFLVRHLDIDNCI 140
Cdd:cd18269   119 SYLQKRLSLSNCL 131
BTB_POZ_KLHL17_actinfilin cd18246
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 33-135 1.30e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also called actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GLUR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in actin-based neuronal function. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349555 [Multi-domain]  Cd Length: 139  Bit Score: 88.16  E-value: 1.30e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  33 GLFTDITLQCPSGIIfHCHRAVLAACSNYFKAMFTADMKEKFKSKIKLSGIHHDILEGLVNYAYTSQIEITKRNVQSLLE 112
Cdd:cd18246    37 GLLCDIVLHVGTKEI-KAHKVVLASCSPYFHAMFTNEMSESRQTHVTLHDIDPQALEQLVQYAYTAEIVVGEGNVQTLLP 115

                          90       100
                  ....*....|....*....|...
gi 2772229914 113 AADLLQFLSVKKACEQFLVRHLD 135
Cdd:cd18246   116 AASLLQLNGVRDACCKFLLSQLD 138
BTB_POZ_KBTBD12 cd18276
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 36-142 1.78e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also called Kelch domain-containing protein 6 (KLHDC6), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349585 [Multi-domain]  Cd Length: 127  Bit Score: 84.47  E-value: 1.78e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  36 TDITLqCPSGIIFHCHRAVLAACSNYFKAMFTADMKEKFKSKIKLSGIHHDILEGLVNYAYTSQIEITKRNVQSLLEAAD 115
Cdd:cd18276    22 TDVVL-VAEGEKFPCHRLVLAAFSPYFKAMFTCGLMECSQREVVLHDITAESVSIILNYMYSSDLHLTNSNVQGVATAAF 100

                          90       100
                  ....*....|....*....|....*..
gi 2772229914 116 LLQFLSVKKACEQFLVRHLDIDNCIGM 142
Cdd:cd18276   101 FLQMEDIFSVCQKYMMDHMDASNCLGI 127
BTB_POZ_KLHL15 cd18244
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-139 2.81e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that targets the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits. It also plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR), by targeting the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. KLHL15 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349553 [Multi-domain]  Cd Length: 137  Bit Score: 84.24  E-value: 2.81e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  13 FKDSSHPVDFLDAFRTFYMDGLFTDITLqcpsgII----FHCHRAVLAACSNYFKAMFTADMKEKFKSKIKLSGIHHDIL 88
Cdd:cd18244     8 YNSSIHDTSVSAGFRALYEEGLLLDVTL-----VIedhqFQAHKALLATQSDYFRIMFTADMRERDQDKIHLKGLTATGF 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2772229914  89 EGLVNYAYTSQIEITKRNVQSLLEAADLLQFLSVKKACEQFLVRHLDIDNC 139
Cdd:cd18244    83 SHVLQFMYYGTIELSMLTVHEILQAAMYVQLTEVVKFCCSFLLAKICLDNC 133
BACK_KLHL18 cd18457
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as ...
 134-226 3.36e-19

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A.


Pssm-ID: 350532 [Multi-domain]  Cd Length: 107  Bit Score: 83.13  E-value: 3.36e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914 134 LDIDNCIGMHSFAEFHVCSELEKESRRILCSRFKEVWQQEEFLEISLEKFLFILSRKNLSVWKEEAILEPVIKWTAHDVE 213
Cdd:cd18457     1 LHPNNCLGIRQFAETMMCSSLVDAANKYIQQHFIEVSKSEEFLALSKEEVLEILSRDELNVKSEEQVFEAALAWVKYDRE 80

                          90
                  ....*....|...
gi 2772229914 214 NRVECLYNLLSYV 226
Cdd:cd18457    81 NREEYLPELLSKV 93
BACK_KEL_like cd18508
BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster ring canal kelch ...
 135-211 3.97e-19

BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster ring canal kelch protein (KEL) and similar proteins; KEL, also termed kelch short protein, is a component of ring canals that regulates the flow of cytoplasm between cells. It binds actin and may be involved in the regulation of cytoplasm flow from nurse cells to the oocyte during oogenesis.


Pssm-ID: 350583 [Multi-domain]  Cd Length: 77  Bit Score: 81.69  E-value: 3.97e-19
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2772229914 135 DIDNCIGMHSFAEFHVCSELEKESRRILCSRFKEVWQQEEFLEISLEKFLFILSRKNLSVWKEEAILEPVIKWTAHD 211
Cdd:cd18508     1 DATNCLGIHEFADAHSCVELEEAAQNYIYQHFNEVIQGEEFLSLDHESLTELISSDRLNVPSEERVYEAAVAWLKHD 77
BTB_POZ_KLHL32 cd18261
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 12-135 5.20e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also called BTB and kelch domain-containing protein 5 (BKLHD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Deletion of KLHL32 may be ssociated with Tourette syndrome and obsessive-compulsive disorder. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349570 [Multi-domain]  Cd Length: 133  Bit Score: 83.48  E-value: 5.20e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  12 LFKDSSHPVDFLDAFRTFYMDGLFTDITLQCPSGIiFHCHRAVLAACSNYFKAMFTADMKEKFKSKIKLSGIHHDILEGL 91
Cdd:cd18261     5 LCQSKSHKDAVLAALNQQRNDGILCDITLVAEEQK-FHAHKAVLAACSDYFRAMFSLCMVESEADEVNLHGVTSLGLKQA 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 2772229914  92 VNYAYTSQIEITKRNVQSLLEAADLLQFLSVKKACEQFLVRHLD 135
Cdd:cd18261    84 LDFAYTGQILLEPGVIQDVLAAGSHLQLLELLSLCSHYLIQELN 127
PHA02713 PHA02713
hypothetical protein; Provisional
 32-445 8.43e-19

hypothetical protein; Provisional


Pssm-ID: 165086 [Multi-domain]  Cd Length: 557  Bit Score: 89.68  E-value: 8.43e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  32 DGLFTDITLQCPSGIIFHCHRAVLAACSNYFKAMFTADM-KEKFKSKIKLSGIHHDILEGLVNYAYTSQieITKRNVQSL 110
Cdd:PHA02713   22 DDILCDVIITIGDGEEIKAHKTILAAGSKYFRTLFTTPMiIRDLVTRVNLQMFDKDAVKNIVQYLYNRH--ISSMNVIDV 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914 111 LEAADLLQFLSVKKACEQFLVRHLDIDNCIGMHSFAEFHVCSELEKESRRILCSRFKEVWQQEEFLEISLEKFLFILS-R 189
Cdd:PHA02713  100 LKCADYLLIDDLVTDCESYIKDYTNHDTCIYMYHRLYEMSHIPIVKYIKRMLMSNIPTLITTDAFKKTVFEILFDIIStN 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914 190 KNLSVWKEEAILEPVIKWTAHD--VENRVECLYNLLSYVNIDIDP---VYLKTALGLQRSC---LLTENKIRSLI----- 256
Cdd:PHA02713  180 DNVYLYREGYKVTILLKWLEYNyiTEEQLLCILSCIDIQNLDKKSrllLYSNKTINMYPSCiqfLLDNKQNRNIIprqlc 259

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914 257 -------YNALNPmhkeisqrsTATMYIIGGYYWHPLSEVHiwDPLTNvwiqgaeipdytresYGVTCLGPNIYVTGGYR 329
Cdd:PHA02713  260 lvchdtkYNVCNP---------CILVYNINTMEYSVISTIP--NHIIN---------------YASAIVDNEIIIAGGYN 313

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914 330 TDNIdALDTVWIYNSEGDEWTEGLPMLNARYYHCAVTLGGCVYALGGYRKGAPAEEAEFYDPLKEKWLPIANMIKGVGNA 409
Cdd:PHA02713  314 FNNP-SLNKVYKINIENKIHVELPPMIKNRCRFSLAVIDDTIYAIGGQNGTNVERTIECYTMGDDKWKMLPDMPIALSSY 392

                         410       420       430
                  ....*....|....*....|....*....|....*.
gi 2772229914 410 TACVLHEVIYVIGGHCGYRGSCTYDKVQSYNSDINE 445
Cdd:PHA02713  393 GMCVLDQYIYIIGGRTEHIDYTSVHHMNSIDMEEDT 428
BTB_POZ_KBTBD4 cd18272
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 7-140 1.73e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also called BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349581 [Multi-domain]  Cd Length: 140  Bit Score: 82.25  E-value: 1.73e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914   7 EDYI--YLFKDSSHPVDFLDAFRTFYM-DGLFTDITLQCpSGIIFHCHRAVLAACSNYFKAMFTADMKEKFKSKIKLSGI 83
Cdd:cd18272     1 ENYFvsYTFTDRSHSSRVAQSIMDLCLeDGLFADVTISV-EGKEFQLHRLVLSAQSCFFRSMFTSNLKEARNRVIELKDV 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2772229914  84 HHDILEGLVNYAYTSQIEITKRNVQSLLEAADLLQFLSVKKACEQFLVRHLDIDNCI 140
Cdd:cd18272    80 SESVFQLLVDYIYHGTVKLRVEELQETYEVADMYQLTALFEECSRFLARTVQVRNCL 136
BTB_POZ_KLHL5 cd18337
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 51-142 2.21e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It is abundantly expressed in the ovary, adrenal gland, and thymus. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349646 [Multi-domain]  Cd Length: 130  Bit Score: 81.65  E-value: 2.21e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  51 HRAVLAACSNYFKAMFTADMKEKFKSKIKLSGIHHDILEGLVNYAYTSQIEITKRNVQSLLEAADLLQFLSVKKACEQFL 130
Cdd:cd18337    38 HRLVLSSVSDYFAAMFTNDVREAKQEEIKMEGVEPNALWALVQYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFL 117

                          90
                  ....*....|..
gi 2772229914 131 VRHLDIDNCIGM 142
Cdd:cd18337   118 MKQLHPSNCLGI 129
BACK_KLHL19_KEAP1 cd18458
BACK (BTB and C-terminal Kelch) domain found in Kelch-like ECH-associated protein 1 (KEAP1); ...
 134-223 2.25e-18

BACK (BTB and C-terminal Kelch) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also termed cytosolic inhibitor of Nrf2 (INrf2), or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression.


Pssm-ID: 350533 [Multi-domain]  Cd Length: 91  Bit Score: 80.03  E-value: 2.25e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914 134 LDIDNCIGMHSFAEFHVCSELEKESRRILCSRFKEVWQQEEFLEISLEKFLFILSRKNLSVWKEEAILEPVIKWTAHDVE 213
Cdd:cd18458     2 LDPSNCIGIANFAEQHGCTELHKKAREYIYMHFSEVSQSEEFFNLSPCQLVALISRDELNVRCESEVYNAVIRWVKYDEE 81

                          90
                  ....*....|
gi 2772229914 214 NRVECLYNLL 223
Cdd:cd18458    82 NRRQYLEALL 91
BACK_KLHL8 cd18448
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a ...
 133-226 2.32e-18

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL8) ubiquitin ligase complex mediates ubiquitination and degradation of RAPSN.


Pssm-ID: 350523 [Multi-domain]  Cd Length: 97  Bit Score: 80.43  E-value: 2.32e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914 133 HLDIDNCIGMHSFAEFHVCSELEKESRRILCSRFKEVWQQEEFLEISLEKFLFILSRKNLSVWKEEAILEPVIKWTAHDV 212
Cdd:cd18448     1 HLHPSNCLGVRTFAEQHNRVDLMKMADKYACDHFNEVVECEEFVSISAQHLEKLISSSDLNVESESQVYEAVMKWVKHDP 80

                          90
                  ....*....|....
gi 2772229914 213 ENRVECLYNLLSYV 226
Cdd:cd18448    81 QHRKRHLDDLLSQV 94
BACK_KBTBD2 cd18479
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 134-229 2.71e-18

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulating the insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation.


Pssm-ID: 350554 [Multi-domain]  Cd Length: 96  Bit Score: 80.10  E-value: 2.71e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914 134 LDIDNCIGMHSFAEFHVCSELEKESRRILCSRFKEVWQQEEFLEISLEKFLFILSRKNLSVWKEEAILEPVIKWTAHDVE 213
Cdd:cd18479     1 INAENCVRLLSFADLFSCEELKQSAKRMVEHKFTAVYHQEAFMQLSHDLLIDILSSDNLNVEKEETVREAAMLWLEYNTE 80

                          90
                  ....*....|....*.
gi 2772229914 214 NRVECLYNLLSYVNID 229
Cdd:cd18479    81 SRSQYLSSVLSQIRID 96
BACK_KLHL2_like cd18445
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This ...
 134-226 7.94e-18

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This subfamily includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. Both KLHL2 and KLHL3 function as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins.


Pssm-ID: 350520 [Multi-domain]  Cd Length: 114  Bit Score: 79.20  E-value: 7.94e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914 134 LDIDNCIGMHSFAEFHVCSELEKESRRILCSRFKEVWQQEEFLEISLEKFLFILSRKNLSVWKEEAILEPVIKWTAHDVE 213
Cdd:cd18445     1 LHPSNCLGIRAFADLHSCTDLLKYAQTYTEQHFSEVVKGEEFLLLSKEQVCELISSDDLTVPSEEKVFEAVMSWVNHDPE 80

                          90
                  ....*....|...
gi 2772229914 214 NRVECLYNLLSYV 226
Cdd:cd18445    81 NRKEHLAELLEHV 93
BACK_KLHL29_KBTBD9 cd18468
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29); KLHL29, also ...
 138-235 1.97e-17

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29); KLHL29, also termed Kelch repeat and BTB domain-containing protein 9 (KBTBD9), belongs to the KLHL family. Its function remains unclear. A nuclear receptor subfamily 5, group A, member 2 (NR5A2)-Kelch-like family member 29 (KLHL29) fusion transcript may participate in the origin or progression of some colon cancers.


Pssm-ID: 350543 [Multi-domain]  Cd Length: 102  Bit Score: 77.84  E-value: 1.97e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914 138 NCIGMHSFAEFHVCSELEKESRRILCSRFKEVWQQEEFLEISLEKFLFILSRKNLSVWKEEAILEPVIKWTAHDVENRVE 217
Cdd:cd18468     4 NCLGIWALAEALQCTELHNMAKAYALQNFPDVARQEEILSISKDDIVEYLSHDSLNTKAEELVFETAIKWLKKDPKNRKQ 83

                          90
                  ....*....|....*....
gi 2772229914 218 CLYNLLSYVNID-IDPVYL 235
Cdd:cd18468    84 HIAELLAVVRLPfIHPSYL 102
BACK_KLHL16_gigaxonin cd18455
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, ...
 138-226 3.32e-17

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, also termed Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy.


Pssm-ID: 350530 [Multi-domain]  Cd Length: 97  Bit Score: 76.97  E-value: 3.32e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914 138 NCIGMHSFAEFHVCSELEKESRRILCSRFKEVWQQEEFLEISLEKFLFILSRKNLSVWKEEAILEPVIKWTAHDVENRVE 217
Cdd:cd18455     4 NCIGIRDFAERFSCPHVHYVATEYLETHFRDVSSTEEFLELSPEKLKELLSRDKLNVGNEEYIFEAVLRWVRHDPEERKV 83


                  ....*....
gi 2772229914 218 CLYNLLSYV 226
Cdd:cd18455    84 HLKDLMSSC 92
BACK_KLHL12 cd18452
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also ...
 134-226 1.96e-16

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also termed CUL3-interacting protein 1 (C3IP1), or DKIR, is a substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport.


Pssm-ID: 350527 [Multi-domain]  Cd Length: 136  Bit Score: 75.90  E-value: 1.96e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914 134 LDIDNCIGMHSFAEFHVCSELEKESRRILCSRFKEVWQQEEFLEISLEKFLFILSRKNLSVWKEEAILEPVIKWTAHDVE 213
Cdd:cd18452     1 LDPSNCLGIRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFMLLSQEEVEKLIKSDEIQVDSEEPVFEAVLNWVKHDKE 80

                          90
                  ....*....|...
gi 2772229914 214 NRVECLYNLLSYV 226
Cdd:cd18452    81 EREDYLPELLQYV 93
BTB_POZ_KLHL1 cd18335
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 51-142 2.45e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton the brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349644 [Multi-domain]  Cd Length: 126  Bit Score: 75.47  E-value: 2.45e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  51 HRAVLAACSNYFKAMFTADMKEKFKSKIKLSGIHHDILEGLVNYAYTSQIEITKRNVQSLLEAADLLQFLSVKKACEQFL 130
Cdd:cd18335    34 HRLVLSAVSDYFAAMFTSDVCEAKQEEIKMEGIDPNALWDLVQFAYTGCLELKEDTIENLLAAACLLQLSQVVEVCCHFL 113

                          90
                  ....*....|..
gi 2772229914 131 VRHLDIDNCIGM 142
Cdd:cd18335   114 MKLLHPSNCLGI 125
BACK_KLHL1_like cd18444
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; ...
 138-226 2.86e-16

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This subfamily contains Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. Members of this subfamily contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels.


Pssm-ID: 350519 [Multi-domain]  Cd Length: 106  Bit Score: 74.67  E-value: 2.86e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914 138 NCIGMHSFAEFHVCSELEKESRRILCSRFKEVWQQEEFLEISLEKFLFILSRKNLSVWKEEAILEPVIKWTAHDVENRVE 217
Cdd:cd18444     6 NCLGIRSFADAQGCTDLLKVAHNYTMEHFMEVIQNQEFLLLPAEEVAKLLASDDLNVPSEETIFHALLLWVKHDLPERKK 85


                  ....*....
gi 2772229914 218 CLYNLLSYV 226
Cdd:cd18444    86 HLAKLLALI 94
BACK_KLHL30 cd18469
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 30 (KLHL30); KLHL30 belongs ...
 134-233 3.28e-16

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 30 (KLHL30); KLHL30 belongs to the KLHL family. Its function remains unclear. Differential expression of the KLHL30 gene has been observed in glioblastoma multiforme versus normal brain.


Pssm-ID: 350544 [Multi-domain]  Cd Length: 104  Bit Score: 74.41  E-value: 3.28e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914 134 LDIDNCIGMHSFAEFHVCSELEKESRRILCSRFKEVWQQEEFLEISLEKFLFILSRKNLSVWKEEAILEPVIKWTAHDVE 213
Cdd:cd18469     3 IDATNCLGICEFGETHGCPEVAAKAWSFLLENFEAVSQEEEFLQLEKERLVACLGDDLLQVRDEQSRLEAVLRWVGHDPQ 82

                          90       100
                  ....*....|....*....|
gi 2772229914 214 NRVECLYNLLSYVNIDIDPV 233
Cdd:cd18469    83 ARAAHLPELLSLVHLSLLTD 102
BACK_KBTBD12 cd18485
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 134-226 3.61e-16

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also termed Kelch domain-containing protein 6 (KLHDC6), is a BTB-Kelch family protein. Its function remains unclear.


Pssm-ID: 350560 [Multi-domain]  Cd Length: 100  Bit Score: 73.99  E-value: 3.61e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914 134 LDIDNCIGMHSFAEfHVCSE-LEKESRRILCSRFKEVWQQEEFLEISLEKFLFILSRKNLSVWKEEAILEPVIKWTAHDV 212
Cdd:cd18485     1 MDASNCLGIYYFAK-QIGAEdLSDRARKYLYQHFTEVCLHEEVLEIEAHQLLTLIKSDDLNVSREESILDLVLRWVNHNR 79

                          90
                  ....*....|....
gi 2772229914 213 ENRVECLYNLLSYV 226
Cdd:cd18485    80 KSRVQHLVELLKQV 93
BACK_KLHL24 cd18463
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also ...
 134-210 4.35e-16

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6), or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of the BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation.


Pssm-ID: 350538 [Multi-domain]  Cd Length: 78  Bit Score: 73.20  E-value: 4.35e-16
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2772229914 134 LDIDNCIGMHSFAEFHVCSELEKESRRILCSRFKEVWQQEEFLEISLEKFLFILSRKNLSVWKEEAILEPVIKWTAH 210
Cdd:cd18463     2 LDPCNCLGIQKFADTHSLKQLFEKCKKFALENFVEVSQHEEFLELCKDELIEYISNDELVVPKEEEVFEAVMRWVYH 78
BTB_POZ_trishanku-like cd18314
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 30-126 5.72e-16

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349623 [Multi-domain]  Cd Length: 96  Bit Score: 73.53  E-value: 5.72e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  30 YMDGLFTDITLQCpSGIIFHCHRAVLAACSNYFKAMFTADMKEKFKSKIKLSGIHHDILEGLVNYAYTSQIEITKRNVQS 109
Cdd:cd18314     1 YNDSEFSDVVLCV-GDRKFFAHRIVLCARSPVFRSMLTGSMIESNLKEVTLEDVEPEIFETVLKYMYTGQVTLSEENVLD 79

                          90
                  ....*....|....*..
gi 2772229914 110 LLEAADLLQFLSVKKAC 126
Cdd:cd18314    80 LLMLASKYQVPDLEKLC 96
BTB_POZ_KLHL16_gigaxonin cd18245
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-130 5.95e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349554 [Multi-domain]  Cd Length: 111  Bit Score: 73.91  E-value: 5.95e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  23 LDAFRTFYMDGLFTDITLQCpSGIIFHCHRAVLAACSNYFKAMFTADMKEKFKS--KIKLSGIHHDILEGLVNYAYTSQI 100
Cdd:cd18245     2 LRALNSFREEPHLCDATLVV-GGEEIPVQKNVLAAASPYFRAKLNYNPPKDDGStyKIELEGISVEVMEEILDYIYTGQI 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 2772229914 101 EITKRNVQSLLEAADLLQFLSVKKACEQFL 130
Cdd:cd18245    81 KLSEDNIQDIVQAADLLLMTDLKDLCCEFL 110
BACK_KLHL3 cd18513
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as ...
 138-232 5.99e-16

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as a substrate adapter in Cullin3 (Cul3) E3 ubiquitin ligase complexes. It is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation.


Pssm-ID: 350588 [Multi-domain]  Cd Length: 130  Bit Score: 74.72  E-value: 5.99e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914 138 NCIGMHSFAEFHVCSELEKESRRILCSRFKEVWQQEEFLEISLEKFLFILSRKNLSVWKEEAILEPVIKWTAHDVENRVE 217
Cdd:cd18513     5 NCLGIRAFADVHTCTELLQQANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSDKLTVSSEEKVFEAVISWIKYDKEARLE 84

                          90
                  ....*....|....*
gi 2772229914 218 CLYNLLSYVNIDIDP 232
Cdd:cd18513    85 HMAKLMEHVRLPLLP 99
BTB_POZ_KLHL41_KBTBD10 cd18341
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-142 6.71e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 41 (KLHL41); KLHL41 is also called Kel-like protein 23, Kelch repeat and BTB domain-containing protein 10 (KBTBD10), Kelch-related protein 1 (Krp1), or sarcosine. It is a novel kelch-related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349650 [Multi-domain]  Cd Length: 133  Bit Score: 74.50  E-value: 6.71e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  28 TFYMDGL--------FTDITLQCPSGIiFHCHRAVLAACSNYFKAMFTADMKEKFKSKIKLSGIHHDILEGLVNYAYTSQ 99
Cdd:cd18341    12 TLLQDGLkelldenkFVDCTLKAGDKS-LPCHRLILAACSPYFREYFLSEESEEKKKEVVLDNVDPNIMDMILKYLYSAE 90

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 2772229914 100 IEITKRNVQSLLEAADLLQFLSVKKACEQFLVRHLDIDNCIGM 142
Cdd:cd18341    91 IDLNDGNVQDIFALASRFQIPSVFTVCVTYLQKRLSPANCLAI 133
BTB_POZ_KLHL29_KBTBD9 cd18258
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 35-141 7.22e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 29 (KLHL29); KLHL29 is also called Kelch repeat and BTB domain-containing protein 9 (KBTBD9). A novel fusion transcript NR5A2-KLHL29FT, resulting from transchromosomal insertion, may influence the origin or progression of colon cancer. KLHL29 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349567 [Multi-domain]  Cd Length: 125  Bit Score: 74.24  E-value: 7.22e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  35 FTDITLQCpSGIIFHCHRAVLAACSNYFKAMF---TADMKEKFKSKIKLSGIHHDILEGLVNYAYTSQIEITKRNVQSLL 111
Cdd:cd18258    17 FTDLKIIV-EGKEFEVHQNVLASCSLYFKDLIkrsSRDSGGGEKLELTMSNINADVLELLLEFVYTGSLIIDSANAKTLL 95

                          90       100       110
                  ....*....|....*....|....*....|
gi 2772229914 112 EAADLLQFLSVKKACEQFLVRHLDIDNCIG 141
Cdd:cd18258    96 EAANKFQFHTFCKVCVSFLEKQLTASNCLG 125
BTB_POZ_SPOP-like cd18279
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 34-138 1.59e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349588 [Multi-domain]  Cd Length: 120  Bit Score: 72.95  E-value: 1.59e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  34 LFTDITLqCPSGIIFHCHRAVLAACSNYFKAMFTADMKEKFKSKIKLSGIHHDILEGLVNYAYTSQIEITKRNVQSLLEA 113
Cdd:cd18279    17 RFTDCCL-CVGGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVDPEVFKEMMRFIYTGKAPNLDKMADDLLAA 95

                          90       100
                  ....*....|....*....|....*
gi 2772229914 114 ADLLQFLSVKKACEQFLVRHLDIDN 138
Cdd:cd18279    96 ADKYALERLKVMCEDALCSNLSVEN 120
BTB_POZ_KLHL34 cd18264
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-140 1.90e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 34 (KLHL34); KLHL34 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The methylation status of KLHL34 cg14232291 appears to be predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349573 [Multi-domain]  Cd Length: 136  Bit Score: 73.29  E-value: 1.90e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  11 YLFKDSSHPVDFLDAFRTFYMDGLFTDITLQCpSGIIFHCHRAVLAACSNYFKAMFTADMKEKFKSKIKLSGIHHDILEG 90
Cdd:cd18264     4 FLAYSKSHGEAVLSQYQSLRAEGFLCDVVLEA-EGNEFPAHRSLLACSSDYFRALFKDYTQESKARVIHLPVVSAAGLQR 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 2772229914  91 LVNYAYTSQIEITKRNVQSLLEAADLLQFLSVKKACEQFLVRHLDIDNCI 140
Cdd:cd18264    83 VLDFIYTSWLSLSLDTLEDTLEAASYLQVTEAIGLCSQYLINNLAPENCC 132
BACK_KLHL2_Mayven cd18512
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also ...
 138-228 2.21e-15

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation.


Pssm-ID: 350587 [Multi-domain]  Cd Length: 130  Bit Score: 72.76  E-value: 2.21e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914 138 NCIGMHSFAEFHVCSELEKESRRILCSRFKEVWQQEEFLEISLEKFLFILSRKNLSVWKEEAILEPVIKWTAHDVENRVE 217
Cdd:cd18512     5 NCLGIRAFADMHACTELLNQANTYAEQHFSDVVLSEEFLNLGIEQVCSLIASDKLTISSEEKVFEAVIAWVNHDKEVRQE 84

                          90
                  ....*....|.
gi 2772229914 218 CLYNLLSYVNI 228
Cdd:cd18512    85 HMAHLMEHVRL 95
BACK_KBTBD3 cd18480
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 134-215 2.47e-15

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also termed BTB and kelch domain-containing protein 3 (BKLHD3), is a BTB-Kelch family protein. Its function remains unclear.


Pssm-ID: 350555 [Multi-domain]  Cd Length: 82  Bit Score: 71.20  E-value: 2.47e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914 134 LDIDNCIGMHSFAEFHVCSELEKESRRILCSRFKEVWQQEEFLEISLEKFLFILSRKNLSVWKEEAILEPVIKWTAHDVE 213
Cdd:cd18480     1 LDLSNCLQLLSFAESYGSTRLLDHALEFVMQHFSLLSQSQEFLELNFEVLEKILEADELNVPDEEAVLKAVLRWTKHDLE 80


                  ..
gi 2772229914 214 NR 215
Cdd:cd18480    81 AR 82
BTB_POZ_KLHL36 cd18266
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 12-146 3.32e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349575 [Multi-domain]  Cd Length: 135  Bit Score: 72.62  E-value: 3.32e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  12 LFKDSSHPVDFLDAFRTFYMDGLFTDITLQCPSGIIfHCHRAVLAACSNYFKAMFTADMKEKFKSKIKLSGIHHDILEGL 91
Cdd:cd18266     2 VYRWADHSNLVLQGLNEQRQRGLFCDVVLVADEQRV-PAHRNLLAVCSDYFNSMFTIGMREAHQKEVELVGASYIGLKAV 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2772229914  92 VNYAYTSQIEITKRNVQSLLEAADLLQFLSVKKACEQFLVRHLDIDNCIGMHSFA 146
Cdd:cd18266    81 IDFLYSSELPLDGGNIDYVLETAHLLQIWKVVDFCCEYLENEVSEENYLYLQELA 135
BTB_POZ_ABTB2-like cd18297
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 45-138 3.77e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349606 [Multi-domain]  Cd Length: 117  Bit Score: 71.92  E-value: 3.77e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  45 GIIFHCHRAVLAACSNYFKAMFTADMKEKFKSKIKLSGIHHDILEGLVNYAYTSQIEITK---RNVQSLLEAADLLQFLS 121
Cdd:cd18297    21 GRPFYAHKIVLVTASDRFKSMLSSGSTEAQTPVIEIPDIRYDIFQLMMQYLYTGGVESLDvaqDDALELLRAASFFQLDG 100

                          90
                  ....*....|....*..
gi 2772229914 122 VKKACEQFLVRHLDIDN 138
Cdd:cd18297   101 LKRHCEILLSQQIDLDN 117
BTB_POZ_roadkill-like cd18345
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 35-138 4.85e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein roadkill and similar proteins; Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349654 [Multi-domain]  Cd Length: 121  Bit Score: 71.80  E-value: 4.85e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  35 FTDITLqCPSGIIFHCHRAVLAACSNYFKAMFTADMKEKFKSKIKLSGIHHDILEGLVNYAYTSQIEITKRNVQSLLEAA 114
Cdd:cd18345    18 FSDVTL-CVGGREFQAHKAILAARSPVFNAMFEHEMEERKQNRVEITDVDHEVMREMLRFIYTGKAPNLDKMADDLLAAA 96

                          90       100
                  ....*....|....*....|....
gi 2772229914 115 DLLQFLSVKKACEQFLVRHLDIDN 138
Cdd:cd18345    97 DKYALERLKVMCEEALCSNLSVEN 120
BTB_POZ_ZBTB7A cd18326
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 18-130 4.85e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A); ZBTB7A is also called factor binding IST protein 1 (FBI-1), factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor (LRF), POZ and Krueppel erythroid myeloid ontogenic factor, POK erythroid myeloid ontogenic factor, Pokemon, TTF-I-interacting peptide 21 (TIP21), or zinc finger protein 857A (ZNF857A). It is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. It has been implicated in carcinogenesis and cell differentiation and development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349635 [Multi-domain]  Cd Length: 120  Bit Score: 71.50  E-value: 4.85e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  18 HPVDFLDAFRTFYMDGLFTDITLqCPSGIIFHCHRAVLAACSNYFKAMFTADMKEKFKSKIKLSGIHHDILEGLVNYAYT 97
Cdd:cd18326     8 HSSDILSSLNEQRTQGLLCDVVI-LVEGREFPTHRSVLAACSQYFKKLFTSGAVVDQQNVYEIDFVSAEALTALLDFAYT 86

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2772229914  98 SQIEITKRNVQSLLEAADLLQFLSVKKACEQFL 130
Cdd:cd18326    87 ATLTVSTSNVGDILSAARLLEIPAVSHVCADLL 119
BTB_POZ_BAB-like cd18315
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 35-118 5.81e-15

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349624 [Multi-domain]  Cd Length: 85  Bit Score: 70.27  E-value: 5.81e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  35 FTDITLQCpSGIIFHCHRAVLAACSNYFKAMFTADMKEKfKSKIKLSGIHHDILEGLVNYAYTSQIEITKRNVQSLLEAA 114
Cdd:cd18315     1 LVDVTLAC-EGGSLKAHKLVLAAASPYFAALLKETPPDE-HPVIILPDVPYSELKALLDFIYTGEVNVSQEQLESLLKLA 78


                  ....
gi 2772229914 115 DLLQ 118
Cdd:cd18315    79 ELLQ 82
BTB_POZ_KLHL22 cd18251
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-138 1.56e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates mono-ubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349560 [Multi-domain]  Cd Length: 125  Bit Score: 70.23  E-value: 1.56e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  13 FKDSSHPVDFLDAFRTFYMDGLFTDITLQCpSGIIFHCHRAVLAACSNYFKAMFTADMKEKFKSKIKLSGIHHDILEGLV 92
Cdd:cd18251     1 YRSVAHSQALLDGLVALRDSGILFDVVLVV-EGKPIEAHRILLAASCDYFRGMFAGGLREMQQTEVLIHGVSYNAMCKIL 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 2772229914  93 NYAYTSQIEITKRNVQSLLEAADLLQFLSVKKACEQFLVRHLDIDN 138
Cdd:cd18251    80 DFIYTSELELSLDNVQETLTAACQLQIPEVIGFCCDFLMSWVDNEN 125
BTB_POZ_ZBTB44 cd18228
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 17-130 2.81e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44); ZBTB44, also called BTB/POZ domain-containing protein 15 (BTBD15) or zinc finger protein 851 (ZNF851), may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB44 showed a suggestive association with disease progression of Crohn's disease. ZBTB44 has also preferentially been recognized by sera of patients with peripheral T-cell lymphoma (PTCL). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349537 [Multi-domain]  Cd Length: 126  Bit Score: 69.50  E-value: 2.81e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  17 SHPVDFLDAFRTFYMDGLFTDITLQCpSGIIFHCHRAVLAACSNYFKAMF-----TADMKEKFKSKIKLSgIHHDILEG- 90
Cdd:cd18228     1 SHSQELLGKLNSLRNEGHFCDVTIRV-QDKIFRAHKVVLAACSDFFRSKLvgqasPRLVLVSPAGKCVLD-LHHVTVTGf 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 2772229914  91 --LVNYAYTSQIEITKRNVQSLLEAADLLQFLSVKKACEQFL 130
Cdd:cd18228    79 apLLEYAYTSTLSINTENIIDVLAAASYMQMFNVANTCSEFM 120
PHA02790 PHA02790
Kelch-like protein; Provisional
 54-539 3.87e-14

Kelch-like protein; Provisional


Pssm-ID: 165153 [Multi-domain]  Cd Length: 480  Bit Score: 74.69  E-value: 3.87e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  54 VLAACSNYFKAmftaDMKEKF-KSKIKLSGIHHDI----LEGLVNYAYTSQIEITKRNVQSLLEAADLLQFLSVKKACEQ 128
Cdd:PHA02790   39 ILKKLSPYFRT----HLRQKYtKNKDPVTRVCLDLdihsLTSIVIYSYTGKVYIDSHNVVNLLRASILTSVEFIIYTCIN 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914 129 FLVRHLDIDNCIGMHSFAEFHVCSELEKESRRILCSRFKEVWQQ--EEFLEISLEkflFILSRKNLSVWKEEAILEPVIK 206
Cdd:PHA02790  115 FILRDFRKEYCVECYMMGIEYGLSNLLCHTKDFIAKHFLELEDDiiDNFDYLSMK---LILESDELNVPDEDYVVDFVIK 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914 207 WTAhdveNRVECLYNLLSYVNIDIdpvylktalglqRSCLLTENKIRSL--IYNALNPMHKEISQRSTatmyiiggyYWH 284
Cdd:PHA02790  192 WYM----KRRNRLGNLLLLIKNVI------------RSNYLSPRGINNVkwILDCTKIFHCDKQPRKS---------YKY 246

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914 285 PLSEVHI-WDPLTNVWIQGAEipdytresygvTCLGPNIYVTGGYRTDNIDalDTVWIYNSEGDEWTEGLPMLNARYYHC 363
Cdd:PHA02790  247 PFIEYPMnMDQIIDIFHMCTS-----------THVGEVVYLIGGWMNNEIH--NNAIAVNYISNNWIPIPPMNSPRLYAS 313

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914 364 AVTLGGCVYALGGYRKGAPAEEAEFYDplkEKWLPIANMIKGVGNATACVLHEVIYVIGGHcgyrgSCTYDKVQSYNSDI 443
Cdd:PHA02790  314 GVPANNKLYVVGGLPNPTSVERWFHGD---AAWVNMPSLLKPRCNPAVASINNVIYVIGGH-----SETDTTTEYLLPNH 385

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914 444 NEWSLITASPHPEYGLCSVPFENKLYLVGGQttiTECYDPEQNEWRETAPMMERRMECGAVIMNGCIYVTGGysYSKGTY 523
Cdd:PHA02790  386 DQWQFGPSTYYPHYKSCALVFGRRLFLVGRN---AEFYCESSNTWTLIDDPIYPRDNPELIIVDNKLLLIGG--FYRGSY 460

                         490
                  ....*....|....*.
gi 2772229914 524 LQSIEKYDPDLNKWEI 539
Cdd:PHA02790  461 IDTIEVYNNRTYSWNI 476
BTB_POZ_KLHL11 cd18241
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 33-139 5.16e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349550 [Multi-domain]  Cd Length: 135  Bit Score: 69.12  E-value: 5.16e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  33 GLFTDITL--QCPSGIIFHCHRAVLAACSNYFKAMFTADMKEKFKSKIKL------SGIHHDILEGLVNYAYTSQIEITK 104
Cdd:cd18241    21 GLFCDITLafGGAGGREFRAHRSVLAAATEYFTPLLSGQFSESRSGRVEMrkwssePGPDPDTVEAVIQYMYTGRIRVST 100

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 2772229914 105 RNVQSLLEAADLLQFLSVKKACEQFLVRHLDIDNC 139
Cdd:cd18241   101 GNVHEVLELADRFLLIRLKEFCGEFLKKKLNLSNC 135
BTB2_POZ_KLHL33 cd18263
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 23-140 6.51e-14

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349572 [Multi-domain]  Cd Length: 118  Bit Score: 68.30  E-value: 6.51e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  23 LDAFRTFYMDGLFTDITLQCpSGIIFHCHRAVLAACSNYFKAMFTADMKEKFKSKIKLSGIHHDILEGLVNYAYTSQIEI 102
Cdd:cd18263     1 LQSIEGLWEKGVGCDVQLEA-DGSIFRVHRVILAAGSDYFRAMFTSGMKESTQSVVQLPTIPAKDLRLLISFAYSGILHL 79

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 2772229914 103 TKRNVQSLLEAADLLQFLSVKKACEQFLVRHLDIDNCI 140
Cdd:cd18263    80 SWENLFEATCTALQLQISGALALCLDFLQREISPARCL 117
BTB2_POZ_RhoBTB cd18300
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 27-134 1.04e-13

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349609 [Multi-domain]  Cd Length: 108  Bit Score: 67.26  E-value: 1.04e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  27 RTFYMDGLFTDITLQCPSGIIFhCHRAVLAACSNYFKAMFTADMKEKFKSKIKLSGIHHDILEGLVNYAYTSQIEITK-R 105
Cdd:cd18300     1 KLFLNKGLFSDVTFIVEDGTIP-AHKALLVARCDVMAAMFGGNFRESSAKEVELPGVSKETFLALLEYLYTDQAPILEdG 79

                          90       100
                  ....*....|....*....|....*....
gi 2772229914 106 NVQSLLEAADLLQFLSVKKACEQFLVRHL 134
Cdd:cd18300    80 DCVGLIVLANRLCLPRLVALCEQYIVKEL 108
BTB_POZ_ZBTB7 cd18198
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 18-130 1.07e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7 (ZBTB7); There are three ZBTB7 isoforms: ZBTB7A, ZBTB7B, and ZBTB7C. ZBTB7A is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. ZBTB7B is a transcriptional regulator of extracellular matrix gene expression. ZBTB7C is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. ZBTB7 isoforms contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349507 [Multi-domain]  Cd Length: 120  Bit Score: 67.58  E-value: 1.07e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  18 HPVDFLDAFRTFYMDGLFTDITLQCpSGIIFHCHRAVLAACSNYFKAMFTADMKEKFKSKIKLSGIHHDILEGLVNYAYT 97
Cdd:cd18198     8 HSSEILSGLNEQRTQGLLCDVVILV-QGREYRTHRSVLAACSQYFKKLFTSGAVVDQQNVYEIDFVSPEALTALLEFAYT 86

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2772229914  98 SQIEITKRNVQSLLEAADLLQFLSVKKACEQFL 130
Cdd:cd18198    87 ATLTVSTANVGDILSAARLLEIPCVSHVCAEIL 119
BTB_POZ_ZBTB14 cd18204
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 18-128 1.38e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 14 (ZBTB14); ZBTB14 is also called zinc finger protein 161 (Zfp-161), zinc finger protein 478, zinc finger protein 5 (ZF5), or Zfp-5. It is a novel transcriptional activator of the dopamine transporter, binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. It also binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. ZBTB14 acts as a transcriptional repressor of MYC and thymidine kinase promoters. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349513 [Multi-domain]  Cd Length: 114  Bit Score: 67.37  E-value: 1.38e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  18 HPVDFLDAFRTFYMDGLFTDITLQCPSgIIFHCHRAVLAACSNYFKAMFTaDMKEKFKSKIKLSGIHHDILEGLVNYAYT 97
Cdd:cd18204     1 HKTVFLKTLNEQRLEGEFCDIAIVVED-VKFRAHRCVLAACSTYFKKLFK-KLEVDSSSVIEIDFLRSDIFEEVLNYMYT 78

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2772229914  98 SQIEITKRNVQSLLEAADLLQFLSVKKACEQ 128
Cdd:cd18204    79 AKISVKKEDVNLMMSSGQILGIRFLDKLCSQ 109
BTB_POZ_KLHL31_KBTBD1 cd18260
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 18-140 1.43e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 31 (KLHL31); KLHL31 is also called BTB and kelch domain-containing protein 6 (BKLHD6), Kelch repeat and BTB domain-containing protein 1 (KBTBD1), or Kelch-like protein KLHL. It is a transcriptional repressor in the MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE). It is also a novel modulator of canonical Wnt signaling, which is important for vertebrate myogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349569 [Multi-domain]  Cd Length: 120  Bit Score: 67.53  E-value: 1.43e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  18 HPVDFLDAFRTFYMDGLFTDITLQCPSGIiFHCHRAVLAACSNYFKAMFTadmKEKFKSKIKLSGIHHDILEGLVNYAYT 97
Cdd:cd18260     1 YGANLLEGLNRMRQERFLCDLTIATKTKS-FDVHKVVMASCSEYFRNILK---KDPSLQRVELNDISPLGLATVITYAYT 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 2772229914  98 SQIEITKRNVQSLLEAADLLQFLSVKKACEQFLVRHLDIDNCI 140
Cdd:cd18260    77 GKLTLSLYTIGSTISAASYLQIHALVKMCCDFLMQEMNVENCM 119
BTB_POZ_BTBD9 cd18287
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 30-130 1.45e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349596 [Multi-domain]  Cd Length: 119  Bit Score: 67.26  E-value: 1.45e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  30 YMDGLFTDITLqcpsgII----FHCHRAVLAACSNYFKAMFTADMKEKFKSKIKLSGIHHDILEGLVNYAYTSQIEITK- 104
Cdd:cd18287    17 FLNEEYSDVTF-----VVeekrFPAHRVILAARSEYFRALLYGGMRESQQSEIELKDTNAEAFKALLKYIYTGRLTLTDl 91

                          90       100
                  ....*....|....*....|....*...
gi 2772229914 105 --RNVQSLLEAADLLQFLSVKKACEQFL 130
Cdd:cd18287    92 keDVLLDVLGLAHQYGFEELEAAISDYL 119
BACK_KLHL17 cd18456
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also ...
 134-228 1.57e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also termed actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GluR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in the actin-based neuronal function.


Pssm-ID: 350531 [Multi-domain]  Cd Length: 102  Bit Score: 66.56  E-value: 1.57e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914 134 LDIDNCIGMHSFAEFHVCSELEKESRRILCSRFKEVWQQEEFLEISLEKFLFILSRKNLSVWKEEAILEPVIKWTAHDVE 213
Cdd:cd18456     1 LDPSNCLGIRGFADTHSCSDLLKSAHKYVLQHFVEVSKTEEFMLLPLKQVLDLISSDSLNVPSEEEVYRAVLSWVKHDVD 80

                          90
                  ....*....|....*
gi 2772229914 214 NRVECLYNLLSYVNI 228
Cdd:cd18456    81 GRRQHVPRLMKCVRL 95
BACK_KLHL4 cd18510
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares ...
 138-232 1.69e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein.


Pssm-ID: 350585 [Multi-domain]  Cd Length: 106  Bit Score: 66.86  E-value: 1.69e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914 138 NCIGMHSFAEFHVCSELEKESRRILCSRFKEVWQQEEFLEISLEKFLFILSRKNLSVWKEEAILEPVIKWTAHDVENRVE 217
Cdd:cd18510     6 NCLGIRSFGDAQGCTELLKVAHSYTMEHFLEVIKNQEFLLLPASEIVKLLASDDINVPDEETIFQALMMWVRHDLQNRQK 85

                          90
                  ....*....|....*
gi 2772229914 218 CLYNLLSYVNIDIDP 232
Cdd:cd18510    86 DLGMLLSYIRLPLLP 100
BACK_KLHL28_BTBD5 cd18467
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also ...
 134-228 2.11e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also termed BTB/POZ domain-containing protein 5 (BTBD5), belongs to the KLHL family. Its function remains unclear.


Pssm-ID: 350542 [Multi-domain]  Cd Length: 99  Bit Score: 66.12  E-value: 2.11e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914 134 LDIDNCIGMHSFAEFHVCSELEKESRRILCSRFKEVWQQEEFLEISLEKFLFILSRKNLSVWKEEAILEPVIKWTAHDVE 213
Cdd:cd18467     1 LDPGNCIGISRFAETYGCHDLYLAANKYICQNFEDVCQTEEFFELTHAELDEIVSNDCLNVVTEETVFYALESWIKYDVQ 80

                          90
                  ....*....|....*
gi 2772229914 214 NRVECLYNLLSYVNI 228
Cdd:cd18467    81 ERQKYLAQLLHCVRL 95
BACK cd14733
BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal ...
 135-189 4.00e-13

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal to a BTB domain, in a diverse set of architectures together with Kelch, MATH, and/or TAZ domains. It is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization. Most proteins containing the BACK domain are understood to function as adaptor proteins that play a role in ubiquitination of various substrates.


Pssm-ID: 350515 [Multi-domain]  Cd Length: 55  Bit Score: 63.83  E-value: 4.00e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2772229914 135 DIDNCIGMHSFAEFHVCSELEKESRRILCSRFKEVWQQEEFLEISLEKFLFILSR 189
Cdd:cd14733     1 DPENCLGILELADLYNLEELKEKALKFILENFEEVSKSEEFLELSVELLLELLSS 55
BTB_POZ_ARIA_plant cd18352
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 48-138 6.66e-13

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant ARM repeat protein interacting with ABF2 (ARIA) and similar proteins; ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2, a transcription factor which controls ABA-dependent gene expression via the G-box-type ABA-responsive elements. ARIA is a novel abscisic acid signaling component. It negatively regulates seed germination and young seedling growth. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349661 [Multi-domain]  Cd Length: 116  Bit Score: 65.19  E-value: 6.66e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  48 FHCHRAVLAACSNYFKAMFTADMKEKFKSKIKLSGIHHDILEGLVNYAYTSQIEITKRNVQSLLEAADLLQFLSVKKACE 127
Cdd:cd18352    25 FYAHRIALLASSDAFRAMFDGGYREKEARDIEIPNIRWEVFELMMRFIYTGSVDITNDIAKDLLRAADQYLLEGLKRLCE 104

                          90
                  ....*....|.
gi 2772229914 128 QFLVRHLDIDN 138
Cdd:cd18352   105 YTIAQDLTLEN 115
BACK_KLHL5 cd18511
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares ...
 138-228 7.16e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. It is abundantly expressed in ovary, adrenal gland, and thymus.


Pssm-ID: 350586 [Multi-domain]  Cd Length: 106  Bit Score: 65.09  E-value: 7.16e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914 138 NCIGMHSFAEFHVCSELEKESRRILCSRFKEVWQQEEFLEISLEKFLFILSRKNLSVWKEEAILEPVIKWTAHDVENRVE 217
Cdd:cd18511     6 NCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFLLLPASEIAKLLASDDMNIPNEETILNALLSWVRHDVEQRRK 85

                          90
                  ....*....|.
gi 2772229914 218 CLYNLLSYVNI 228
Cdd:cd18511    86 DLSKLLAYIRL 96
BTB_POZ_BTBD19 cd18294
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 22-130 8.95e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349603 [Multi-domain]  Cd Length: 111  Bit Score: 64.96  E-value: 8.95e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  22 FLDAFRTFYMDGLFTDIT-LQCPSGIIFHCHRAVLAACSNYFKAMF-TADMKEKFKSKIKLSGIHHDILEGLVNYAYTSQ 99
Cdd:cd18294     1 FAADMKSLINNPEFSDVKfLVGPERQEIFAHKCILAARCEVFRAMFlTGPQKESTQSPLVLSDIEPEVFRAVLEFIYTNC 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2772229914 100 IEITKRNVQSLLEAADLLQFLSVKKACEQFL 130
Cdd:cd18294    81 VTLSNHTVIEVLAAAVEYGLDELRKLCERFI 111
BTB_POZ_ZBTB7B_ZBTB15 cd18327
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 33-130 9.47e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7B (ZBTB7B); ZBTB7B is also called Krueppel-related zinc finger protein cKrox, T-helper-inducing POZ/Krueppel-like factor, zinc finger and BTB domain-containing protein 15 (ZBTB15), zinc finger protein 67 (ZNF67), Zfp67, zinc finger protein 857B (ZNF857B), or zinc finger protein Th-POK. It is a transcriptional regulator of extracellular matrix gene expression. It plays widespread and critical roles in T-cell development, particularly as the master regulator of CD4 commitment. It also plays a role as a potent driver of brown fat development and thermogenesis, as well as cold-induced beige fat formation. ZBTB7B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349636 [Multi-domain]  Cd Length: 127  Bit Score: 65.25  E-value: 9.47e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  33 GLFTDITLQCpSGIIFHCHRAVLAACSNYFKAMFTADMKEKFKSKI-------KLSGIHHDILEGLVNYAYTSQIEITKR 105
Cdd:cd18327    23 GLLCDLTIKT-RGLEYRTHRAVLAACSLYFRKLFTGGGGGSGDLGAgggqdvcELDFVGPEALGALLEFAYTATLTISSS 101

                          90       100
                  ....*....|....*....|....*
gi 2772229914 106 NVQSLLEAADLLQFLSVKKACEQFL 130
Cdd:cd18327   102 NMREVLRAARLLEIPCVADACADIL 126
BTB2_POZ_ABTB1_BPOZ1 cd18296
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 35-135 1.13e-12

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349605 [Multi-domain]  Cd Length: 121  Bit Score: 65.01  E-value: 1.13e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  35 FTDITLQCpSGIIFHCHRAVLAACSNYFKAMFTADMKEKFK-----SKIKLSGIHHDILEGLVNYAYTSQIEITKRNVQS 109
Cdd:cd18296    17 FPDVCFQV-EGHRFPCHKAFFCGRSDYFKALLRDHFAESEEnngsiPVVTLHDVSPEVFAIVLYYIYTDDTDLPPENAYD 95

                          90       100
                  ....*....|....*....|....*.
gi 2772229914 110 LLEAADLLQFLSVKKACEQFLVRHLD 135
Cdd:cd18296    96 VLYVADMYLLPGLKRLCGTVLAQSLD 121
BTB_POZ_BTBD18 cd18293
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 32-118 1.21e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 18 (BTBD18); BTBD18 acts as a specific controller for transcription activation through RNA polymerase II elongation at a subset of genomic PIWI-interacting RNA (piRNA) loci. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349602 [Multi-domain]  Cd Length: 120  Bit Score: 64.81  E-value: 1.21e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  32 DGLFTDITLQCpSGIIFHCHRAVLAACSNYFKAMFTADMKEK-FKSKIKLSGIHHDILEGLVNYAYTSQIEITKRNVQSL 110
Cdd:cd18293    12 SGVFCDVLLQA-EGESVPAHCCVLSACSPYLTERLSSEPPPAgQKVVLELQGLKAHTLLKLVDFLYTSELEVSSEEAQDV 90


                  ....*...
gi 2772229914 111 LEAADLLQ 118
Cdd:cd18293    91 LAAARRLQ 98
BACK_KLHL10 cd18450
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 10 (KLHL10); KLHL10 may be ...
 134-211 1.32e-12

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 10 (KLHL10); KLHL10 may be a substrate-specific adapter of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during spermatogenesis.


Pssm-ID: 350525 [Multi-domain]  Cd Length: 80  Bit Score: 63.40  E-value: 1.32e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2772229914 134 LDIDNCIGMHSFAEFHVCSELEKESRRILCSRFKEVWQQ-EEFLEISLEKFLFILSRKNLSVWKEEAILEPVIKWTAHD 211
Cdd:cd18450     1 LTPENCIGIRKFARYYFCPELERKAYRYILRNFEEVAKDsEEFLELSCEELEDIIEDDELNVKEEEVVFEAIVKWIDHD 79
BTB_POZ_ZBTB7C_ZBTB36 cd18328
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 17-126 1.36e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C); ZBTB7C is also called affected by papillomavirus DNA integration in ME180 cells protein 1 (APM-1), zinc finger and BTB domain-containing protein 36 (ZBTB36), zinc finger protein 857C (ZNF857C), or kidney cancer-related POZ domain and Kruppel-like protein (Kr-POK). It is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. It may act as an important regulator of fatty acid synthesis and may induce rapid cancer cell proliferation by increasing palmitate synthesis. The ZBTB7C gene has been identified as a susceptibility gene to ischemic injury. ZBTB7C contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349637 [Multi-domain]  Cd Length: 120  Bit Score: 64.52  E-value: 1.36e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  17 SHPVDFLDAFRTFYMDGLFTDITLqcpsgII----FHCHRAVLAACSNYFKAMFTADMKEKFKSKIKLSGIHHDILEGLV 92
Cdd:cd18328     7 NHSSEVLCSLNEQRHDGLLCDVVL-----IVqdqeYRTHRSVLAACSKYFKKLFTAGTLADQPYVYEIDFVTPEALSAIL 81

                          90       100       110
                  ....*....|....*....|....*....|....
gi 2772229914  93 NYAYTSQIEITKRNVQSLLEAADLLQFLSVKKAC 126
Cdd:cd18328    82 EFAYTSTLTITTSNVKHILNAAQMLEIQCIINVC 115
BTB2_POZ_BTBD8 cd18286
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 30-132 1.93e-12

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349595 [Multi-domain]  Cd Length: 121  Bit Score: 64.20  E-value: 1.93e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  30 YMDGLFTDITLQCPSGIiFHCHRAVLAACSNYFKAMFTADMKEKFKSKIKLSGIHHDILEGLVNYAYTSQIEITKR-NVQ 108
Cdd:cd18286    12 FLNGEDSDITIKVDGKT-FKAHRCILCARSSYFAAMLSGSWAESNSSEITLTGVSHAAVSFVLLFIYGGVLDLPDDvNLG 90

                          90       100
                  ....*....|....*....|....
gi 2772229914 109 SLLEAADLLQFLSVKKACEQFLVR 132
Cdd:cd18286    91 ELLSLADMYGLDGLKDVVAYTLRR 114
BACK_KLHL20 cd18459
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also ...
 134-228 2.24e-12

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also termed Kelch-like ECT2-interacting protein (KLEIP), or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis.


Pssm-ID: 350534 [Multi-domain]  Cd Length: 100  Bit Score: 63.22  E-value: 2.24e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914 134 LDIDNCIGMHSFAEFHVCSELEKESRRILCSRFKEVWQQEEFLEISLEKFLFILSRKNLSVWKEEAILEPVIKWTAHDVE 213
Cdd:cd18459     2 LDPSNCLGIRAFADTHACRELLRIADKFTQHNFQEVMESEEFMLLPVNQLIDIISSDELNVRSEEQVFNAVMAWVKYNIQ 81

                          90
                  ....*....|....*
gi 2772229914 214 NRVECLYNLLSYVNI 228
Cdd:cd18459    82 ERRPHLPQVLQHVRL 96
BACK_KLHL1 cd18509
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a ...
 138-235 2.35e-12

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton in brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein.


Pssm-ID: 350584 [Multi-domain]  Cd Length: 106  Bit Score: 63.50  E-value: 2.35e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914 138 NCIGMHSFAEFHVCSELEKESRRILCSRFKEVWQQEEFLEISLEKFLFILSRKNLSVWKEEAILEPVIKWTAHDVENRVE 217
Cdd:cd18509     6 NCLGIRAFADAQGCIELMKVAHSYTMENIMEVIRNQEFLLLPAEELHKLLASDDVNVPDEETIFHALMMWVKYDMQRRCS 85

                          90
                  ....*....|....*...
gi 2772229914 218 CLYNLLSYVNIDIDPVYL 235
Cdd:cd18509    86 DLSMLLAYIRLPLLPPQL 103
BTB_POZ_KLHL14_printor cd18243
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-138 4.03e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 14 (KLHL14); KLHL14 is also called protein interactor of Torsin-1A (TOR1A), protein interactor of torsinA, or Printor. It is a novel torsinA-interacting protein that preferentially interacts with ATP-free form of TOR1A and is implicated in dystonia pathogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349552 [Multi-domain]  Cd Length: 130  Bit Score: 63.52  E-value: 4.03e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  15 DSSHPVDFLDAFRTFYMDGLFTDITLQCpSGIIFHCHRAVLAACSNYFKAMFTADmkekfksKIKLSGIHHDILEGLVNY 94
Cdd:cd18243    12 DPSHSDNLLHGLNLLWRKQLFCDVTLTA-QGQQFHCHKAVLASCSQYFRSLFSIN-------NLVLQGCSSIGLRLVLEY 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 2772229914  95 AYTSQIEITKRNVQSLLEAADLLQFLSVKKACEQFLVRHLDIDN 138
Cdd:cd18243    84 LYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQFLNDQISVQN 127
BACK_KLHL40_like cd18477
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL40 and KLHL41; The ...
 134-219 4.93e-12

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL40 and KLHL41; The family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells.


Pssm-ID: 350552 [Multi-domain]  Cd Length: 99  Bit Score: 62.17  E-value: 4.93e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914 134 LDIDNCIGMHSFAEFHVCSELEKESRRILCSRFKEVWQQEEFLEISLEKFLFILSRKNLSVWKEEAILEPVIKWTAHDVE 213
Cdd:cd18477     1 LCLGNCLAIFRLGLLLDCPRLAVSARDFICAHFTLVAKDEDFLGLSADELIAIISSDGLNVEKEEAVFEAVMKWVREAKE 80


                  ....*.
gi 2772229914 214 NRVECL 219
Cdd:cd18477    81 NRQKAL 86
BACK_KLHL41_KBTBD10 cd18517
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 41 (KLHL41); KLHL41, also ...
 134-219 5.54e-12

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 41 (KLHL41); KLHL41, also called Kel-like protein 23, or Kelch repeat and BTB domain-containing protein 10, or Kelch-related protein 1 (Krp1), or sarcosine, is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils.


Pssm-ID: 350592 [Multi-domain]  Cd Length: 99  Bit Score: 62.10  E-value: 5.54e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914 134 LDIDNCIGMHSFAEFHVCSELEKESRRILCSRFKEVWQQEEFLEISLEKFLFILSRKNLSVWKEEAILEPVIKWTAHDVE 213
Cdd:cd18517     1 LSVGNCLAIFRLGLLLDCPRLAVSARDFVSDRFEQISKEEDFLQLAPHELIAIISSDSLNVEKEELVFEAVMKWVRTDKE 80


                  ....*.
gi 2772229914 214 NRVECL 219
Cdd:cd18517    81 NRVKSL 86
Kelch smart00612
Kelch domain;
509-557 5.79e-12

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 60.26  E-value: 5.79e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 2772229914  509 CIYVTGGYSYskGTYLQSIEKYDPDLNKWEIVGNLPSAmRSHGCVCVYN 557
Cdd:smart00612   1 KIYVVGGFDG--GQRLKSVEVYDPETNKWTPLPSMPTP-RSGHGVAVIN 46
BACK_KLHL40_KBTBD5 cd18516
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also ...
 134-232 9.20e-12

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5, or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy.


Pssm-ID: 350591 [Multi-domain]  Cd Length: 99  Bit Score: 61.70  E-value: 9.20e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914 134 LDIDNCIGMHSFAEFHVCSELEKESRRILCSRFKEVWQQEEFLEISLEKFLFILSRKNLSVWKEEAILEPVIKWTAHDVE 213
Cdd:cd18516     1 LCLSNCLAIFRLGLLLDCPRLAVAARDFICDRFQLIARDEDFLQLSPDELIAIISSDSLNVEKEEDVFEAVMKWVGKDQE 80

                          90
                  ....*....|....*....
gi 2772229914 214 NRVECLYNLLSYVNIDIDP 232
Cdd:cd18516    81 ERTKALPVLLESIRFRLMP 99
BTB_POZ_ZBTB17_MIZ1 cd18206
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 33-129 1.21e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 17 (ZBTB17); ZBTB1 is also called c-Myc-interacting zinc finger protein 1 (Miz-1), zinc finger protein 151, or zinc finger protein 60. It is a poly-Cys2His2 zinc finger (ZF) transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. ZBTB17 has been implicated in cardiomyopathy and is important in cardiac stress response. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349515 [Multi-domain]  Cd Length: 112  Bit Score: 61.48  E-value: 1.21e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  33 GLFTDITLQCpSGIIFHCHRAVLAACSNYFKAMFTaDMKEKfkskiklsgIHHDI-----LEGLVNYAYTSQIEITKRNV 107
Cdd:cd18206    20 GLLCDCTFVV-DGVDFKAHKAVLAACSEYFRMLFV-DQKDV---------VHLDIsnaagLGQVLEFMYTAKLSLSPENV 88

                          90       100
                  ....*....|....*....|..
gi 2772229914 108 QSLLEAADLLQFLSVKKACEQF 129
Cdd:cd18206    89 DDVLAVATFLQMQDIVTACHAL 110
BTB2_POZ_IBtk cd18302
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 35-138 1.32e-11

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349611 [Multi-domain]  Cd Length: 113  Bit Score: 61.61  E-value: 1.32e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  35 FTDITLQCPSGIIFHCHRAVLAACSNYFKAMFTADMKEKFKSKIKLSGIHHDILEGLVNYAYTSQIEITK--RNVQSL-- 110
Cdd:cd18302     5 LYDVTIVSEDGKEFPCHKCVLVARLEYFHSMLSSSWIEASSCSALTMPIPSDILEIILDYLYTDEASAVKesQNVEFLcn 84

                          90       100
                  ....*....|....*....|....*....
gi 2772229914 111 -LEAADLLQFLSVKKACEQFLVRHLDIDN 138
Cdd:cd18302    85 vLVIADQLLITRLKEICEVALVELLSLKN 113
BTB_POZ_SPOP cd18342
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 24-138 1.61e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP); SPOP, also called HIB homolog 1 or Roadkill homolog 1, is a novel nuclear speckle-type protein which serves as an adaptor of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and proteasomal degradation of target proteins, such as BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349651 [Multi-domain]  Cd Length: 125  Bit Score: 61.66  E-value: 1.61e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  24 DAFRTFYMDGLFTDITLqCPSGIIFHCHRAVLAACSNYFKAMFTADMKEKFKSKIKLSGIHHDILEGLVNYAYTSQIEIT 103
Cdd:cd18342    11 DELGGLWENSRFTDCCL-CVAGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVEPEVFKEMMCFIYTGKAPNL 89

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 2772229914 104 KRNVQSLLEAADLLQFLSVKKACEQFLVRHLDIDN 138
Cdd:cd18342    90 DKMADDLLAAADKYALERLKVMCEDALCSNLSVEN 124
BTB_POZ_ZBTB23_GZF1 cd18211
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 12-128 2.04e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in glial cell line-derived neurotrophic factor-inducible zinc finger protein 1 (GZF1); GZF1 is also called GDNF-inducible zinc finger protein 1, zinc finger and BTB domain-containing protein 23 (ZBTB23), or zinc finger protein 336 (ZNF336). It is a sequence-specific transcriptional repressor that binds the GZF1 responsive element (GRE), with the consensus sequence of 5'-TGCGCN[TG][CA]TATA-3'. It may play a role in renal branching morphogenesis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349520 [Multi-domain]  Cd Length: 128  Bit Score: 61.41  E-value: 2.04e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  12 LFKDSSHPVDFLDAFRTFYMDGLFTDITLQCP---SGIIFHCHRAVLAACSNYFKAMFTADMKEKFK-SKIKLSGIHHDI 87
Cdd:cd18211     2 LLESKSAPSNLLNEMHKLRLLGHLCDVTVQVEhqgSKEEFSAHKAVLAASSKYFKEVFLNEKISDGKnTNVMLNEIYTAD 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2772229914  88 LEGLVNYAYTSQIEITKRNVQSLLEAADLLQFLSVKKACEQ 128
Cdd:cd18211    82 FASFLEFVYTAKVEVEEDRVQRMLEIAEKLKCLDLSETCFQ 122
BTB_POZ_TDPOZ cd18344
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-138 2.42e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in TD and POZ domain-containing proteins (TDPOZ); TDPOZ is a family of bipartite animal and plant proteins that contains a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domain. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. This subfamily contains only mammalian members. Plant TDPOZ proteins contain a MATH domain at the N-terminal region and are named "BTB/POZ and MATH domain-containing proteins (BPM)", not included in this subfamily. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349653 [Multi-domain]  Cd Length: 128  Bit Score: 61.13  E-value: 2.42e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  14 KDSSHPVDflDAFRTFYMDGLFTDITLQCpSGIIFHCHRAVLAACSNYFKAMFTADMKEKFKSKIKLSGIHHDILEGLVN 93
Cdd:cd18344     4 KDPRHMLT--DDLGELWENSLFTDCCLLV-AGHEFRAHKAILAARSPVFRAMFEHEMEERLKNPIEIHDLDPQVFKEMMG 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 2772229914  94 YAYTSQIEITKRNVQS--LLEAADLLQFLSVKKACEQFLVRHLDIDN 138
Cdd:cd18344    81 FIYTGKAPHLHSHSMAcdVLAAADKYGLEGLKVLCEDALCRNLSVEN 127
BACK_KLHL21 cd18460
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a ...
 134-226 5.27e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively.


Pssm-ID: 350535 [Multi-domain]  Cd Length: 101  Bit Score: 59.43  E-value: 5.27e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914 134 LDIDNCIGMHSFAEFHVCSELEKESRRILCSRFKEVWQQEEFLEISLEKFLFILSRKNLSVWKEEAILEPVIKWTAHDVE 213
Cdd:cd18460     1 LDVSNCLEMQDFAEAFACRGLAEAAKRFILRHIVELAKGEQFERLPLKRLLEYLSDDGLCVDKEETAYQIALRWVKADPK 80

                          90
                  ....*....|...
gi 2772229914 214 NRVECLYNLLSYV 226
Cdd:cd18460    81 HRQHFWPELLQHV 93
BACK_KLHL7 cd18447
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a ...
 133-226 5.65e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a BTB-Kelch protein that constitutes a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 cause autosomal-dominant retinitis pigmentosa.


Pssm-ID: 350522 [Multi-domain]  Cd Length: 98  Bit Score: 59.29  E-value: 5.65e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914 133 HLDIDNCIGMHSFAEFHVCSELEKESRRILCSRFKEVWQQEEFLEISLEKFLFILSRKNLSVWKEEAILEPVIKWTAHDV 212
Cdd:cd18447     1 QVDASNCLGISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKYDE 80

                          90
                  ....*....|....
gi 2772229914 213 ENRVECLYNLLSYV 226
Cdd:cd18447    81 PNRQPYMVDILAKV 94
BTB_POZ_SPOPL cd18343
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 35-138 5.97e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL); SPOPL, also called HIB homolog 2 or Roadkill homolog 2, is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The complexes may contain homodimeric SPOPL or the heterodimers formed by speckle-type POZ protein (SPOP) and SPOPL, which are less efficient than ubiquitin ligase complexes containing only SPOP. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349652 [Multi-domain]  Cd Length: 123  Bit Score: 60.02  E-value: 5.97e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  35 FTDITLQCpSGIIFHCHRAVLAACSNYFKAMFTADMKEKFKSKIKLSGIHHDILEGLVNYAYTSQIEITKRNVQSLLEAA 114
Cdd:cd18343    21 FTDCSLFV-GGQEFKAHKSILAARSPVFNAMFEHEMEESKKNRVEINDVDPEVFKEMMRFIYTGKAPNLDKMADNLLAAA 99

                          90       100
                  ....*....|....*....|....
gi 2772229914 115 DLLQFLSVKKACEQFLVRHLDIDN 138
Cdd:cd18343   100 DKYALERLKVMCEEALCNNLSVEN 123
BTB_POZ_CP190-like cd18311
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 22-128 7.76e-11

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster centrosomal protein 190kD (CP190) and similar proteins; CP190 is a large, multi-domain protein, first identified as a centrosome protein with oscillatory localization over the course of the cell cycle. It has an essential function in the nucleus as a chromatin insulator. It is known to associate with the nuclear matrix, components of the RNAi machinery, active promoters and borders of the repressive chromatin domains. CP190 contains an N-terminal BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349620 [Multi-domain]  Cd Length: 110  Bit Score: 59.14  E-value: 7.76e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  22 FLDAFRTFYMDGLFTDITLQCPSGIIFHCHRAVLAACSNYFKAMFTADMKEKfKSKIKLSGIHHDILEGLVNYAYTSQIE 101
Cdd:cd18311     1 FLQRLQNLFNKTEYCDLTLQFRDNEQLKVHRLVLSACTDYFNVLEQTCEIVD-DTLIMPNELQADAVVPVINFMYTGQLE 79

                          90       100
                  ....*....|....*....|....*..
gi 2772229914 102 ITKRNVQSLLEAADLLQFLSVKKACEQ 128
Cdd:cd18311    80 FEEKSYGKLLRTAKELNMTVLLKLLEA 106
BACK_KLHL25_like cd18464
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL25 and KLHL37; The ...
 138-232 8.38e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL25 and KLHL37; The family includes KLHL25 and KLHL37. KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). KLHL37, also called ectoderm-neural cortex protein 1 (ENC-1), or nuclear matrix protein NRP/B, or p53-induced gene 10 protein, is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells.


Pssm-ID: 350539 [Multi-domain]  Cd Length: 98  Bit Score: 58.66  E-value: 8.38e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914 138 NCIGMHSFAEFHVCSELEKESRRILCSRFKEVWQQEEFLEISLEKFLFILSRKNLSVWKEEAILEPVIKWTAHDVENRVE 217
Cdd:cd18464     4 NCLGMLLLSDAHQCQRLYELSWRMCLANFTTLRKTEDFLSLPKDKLLELVSSEELEVEDERLVYEAVIGWIRYDLPRRHE 83

                          90
                  ....*....|....*
gi 2772229914 218 CLYNLLSYVNIDIDP 232
Cdd:cd18464    84 VLPELLRSVRLALLP 98
BACK_KLHL25_ENC2 cd18514
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also ...
 138-232 9.87e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1).


Pssm-ID: 350589 [Multi-domain]  Cd Length: 99  Bit Score: 58.70  E-value: 9.87e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914 138 NCIGMHSFAEFHVCSELEKESRRILCSRFKEVWQQEEFLEISLEKFLFILSRKNLSVWKEEAILEPVIKWTAHDVENRVE 217
Cdd:cd18514     5 NCLGMMLLSDAHQCRRLYELSWRMCLVHFETVRESEDFYSLSKDKLLDLISSDELEIEDEQVVFNAVLQWVKYDLEKRKD 84

                          90
                  ....*....|....*
gi 2772229914 218 CLYNLLSYVNIDIDP 232
Cdd:cd18514    85 YLPELLRNVRLALLP 99
BTB_POZ_ZBTB47_ZNF651 cd18231
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 20-130 1.02e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 47 (ZBTB47); ZBTB47, also called zinc finger protein 651 (ZNF651), is a paralog of ZNF652, a novel zinc-finger transcriptional repressor. It interacts with CBFA2T3 via its carboxy-terminal proline-rich region. CBFA2T3-ZNF651 functions as a transcriptional co-repressor complex. ZBTB47 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349540 [Multi-domain]  Cd Length: 115  Bit Score: 59.17  E-value: 1.02e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  20 VDFLDAFRTFYMDGLFTDITLqCPSGIIFHCHRAVLAACSNYFKAMFTADmKEKFKSKIKLSGIHHDILEGLVNYAYTSQ 99
Cdd:cd18231     1 MDRLNEQRLFQPDLCDVDIVL-VRQRSTFPAHKGVLAAYSQFFHSLFTQN-KQLQRVELSLEALTSQGLQQILNFIYTSK 78

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2772229914 100 IEITKRNVQSLLEAADLLQFLSVKKACEQFL 130
Cdd:cd18231    79 LLVNSCNVQDVLNAAAVLQMNDIAASCQELI 109
Kelch smart00612
Kelch domain;
322-369 1.12e-10

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 56.80  E-value: 1.12e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 2772229914  322 IYVTGGYrtDNIDALDTVWIYNSEGDEWTEGLPMLNARYYHCAVTLGG 369
Cdd:smart00612   2 IYVVGGF--DGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
BACK_KLHL37_ENC1 cd18515
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37); KLHL37, also ...
 138-232 1.86e-10

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37); KLHL37, also called ectoderm-neural cortex protein 1 (ENC-1), or nuclear matrix protein NRP/B, or p53-induced gene 10 protein, is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells.


Pssm-ID: 350590 [Multi-domain]  Cd Length: 98  Bit Score: 57.68  E-value: 1.86e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914 138 NCIGMHSFAEFHVCSELEKESRRILCSRFKEVWQQEEFLEISLEKFLFILSRKNLSVWKEEAILEPVIKWTAHDVENRVE 217
Cdd:cd18515     4 NCLGMLLLSDAHQCTKLYELSWRMCLSNFQTICKTEDFLQLPKDMVVQLLSSEELETEDERLVYEAAINWVNYDLKKRHC 83

                          90
                  ....*....|....*
gi 2772229914 218 CLYNLLSYVNIDIDP 232
Cdd:cd18515    84 YLSELLQTVRLALLP 98
BTB_POZ_BACH1 cd18277
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 10-130 2.26e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 1 (BACH1); BACH1, also called BTB-basic leucine zipper transcription factor 1, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. It can act as repressor or activator. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. It is also a negative regulator of nuclear factor erythroid 2-related factor 2 (Nrf2) that controls antioxidant response elements (ARE)-dependent gene expressions. BACH1 binds to NF-E2 binding sites in vitro, and plays important roles in coordinating transcription activation and repression by MafK. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349586 [Multi-domain]  Cd Length: 120  Bit Score: 58.15  E-value: 2.26e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  10 IYLFKDSSHPVDFLDAFRTFYMDGLFTDITLQCpSGIIFHCHRAVLAACSNYFKAMFT----ADMKEKFKSKIKLSGihh 85
Cdd:cd18277     2 VFAYESSVHSTNVLLSLNDQRKKDVLCDVTILV-EGQRFRAHRSVLAACSSYFHSRIVgqadAELNITLPEEVTVKG--- 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2772229914  86 diLEGLVNYAYTSQIEITKRNVQSLLEAADLLQFLSVKKACEQFL 130
Cdd:cd18277    78 --FEPLIQFAYTAKLILSKDNVDEVCKCVEFLSVHNIEESCFQFL 120
BACK_KBTBD8 cd18483
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 134-215 2.46e-10

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor for a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralogue TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome.


Pssm-ID: 350558 [Multi-domain]  Cd Length: 97  Bit Score: 57.56  E-value: 2.46e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914 134 LDIDNCIGMHSFAEFHVCSELEKESRRILCSRFKEVWQQEEFLEISLEKFLFILSRKNLSVWKEEAILEPVIKWTAHDVE 213
Cdd:cd18483     1 LDPQNSIGVFIFADHYGHQELKERSQDYIRKKFLSVTKEQEFLHLTKDQLISILNSDDLNVEKEEHVYESIIHWFEHEQS 80


                  ..
gi 2772229914 214 NR 215
Cdd:cd18483    81 KR 82
BTB_POZ_ZBTB49 cd18233
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 18-130 2.83e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 49 (ZBTB49); ZBTB49, also called zinc finger protein 509 (ZNF509), is a transcription factor that inhibits cell proliferation by activating either CDKN1A/p21 transcription or RB1 transcription. There are four ZNF509 isoforms generated by alternative splicing. Short ZNF509 (ZNF509S1, -S2 and -S3) isoforms contain one or two out of the seven zinc-fingers contained in long ZNF509 (ZNF509L). ZBTB49 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349542 [Multi-domain]  Cd Length: 112  Bit Score: 57.60  E-value: 2.83e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  18 HPVDFLDAFRTFYMDGLFTDITLQCpSGIIFHCHRAVLAACSNYFKAMFTADMKEK---FKSKIK-LSGIHHdilegLVN 93
Cdd:cd18233     1 HSCHLLQQLHEQRIQGLLCDCMLVV-KGVCFKAHKNVLAAFSQYFRSLFQNSSSQKndvFHLDIKnVGGIGQ-----ILD 74

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2772229914  94 YAYTSQIEITKRNVQSLLEAADLLQFLSVKKACEQFL 130
Cdd:cd18233    75 FMYTSHLDLNQDNVQVMLDIAQCLQVQNVLNMCYTFL 111
BTB_POZ_BACH cd18955
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 48-130 3.26e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog (BACH) proteins; This subfamily includes BACH1 (also called BTB-basic leucine zipper transcription factor 1), BACH2 (also called BTB-basic leucine zipper transcription factor 2), and similar proteins. They belong to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). Subfamily members contain a BTB domain and a basic leucine zipper (bZIP) domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349736 [Multi-domain]  Cd Length: 94  Bit Score: 57.09  E-value: 3.26e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  48 FHCHRAVLAACSNYFKAMFTADMKEKFKskIKL-SGIHHDILEGLVNYAYTSQIEITKRNVQSLLEAADLLQFLSVKKAC 126
Cdd:cd18955    13 FRAHRAVLAACSDYFLSRVVGQTDGDLV--ITLpEEVTVKGFEPLLQFAYTAKLLLSKENVLEVCRCAEFLGVHNIEKAC 90


                  ....
gi 2772229914 127 EQFL 130
Cdd:cd18955    91 FDFL 94
BTB_POZ_ZBTB19_PATZ1 cd18207
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-130 3.84e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1); PATZ1 is also called zinc finger and BTB domain-containing protein 19 (ZBTB19), BTB/POZ domain zinc finger transcription factor, protein kinase A RI subunit alpha-associated protein, zinc finger protein 278, or zinc finger sarcoma gene protein. It is an important transcriptional regulatory factor that regulates divergent pathways depending on the cellular context. For instance, it acts as a transcriptional suppressor that functions in T lymphocytes. It is also a DNA damage-responsive transcription factor that inhibits p53 function. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349516 [Multi-domain]  Cd Length: 128  Bit Score: 57.67  E-value: 3.84e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  11 YLFKDSSHPVDFLDAFRTFYMDG-LFTDITLQCPSGIiFHCHRAVLAACSNYFKAMFTADMKEKFKSK-IKLSGIHHDIL 88
Cdd:cd18207     2 YTYQVSQHSADMLHNLNQQRKSGgRFCDVLLRVGEES-FPAHRAVLAACSEYFESVFSAQEGDGGTPReLEMHTISSKVF 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 2772229914  89 EGLVNYAYTSQIEITKRNVQSLLEAADLLQFLSVKKACEQFL 130
Cdd:cd18207    81 GDILDFAYTSRIVVRLESFPELMTAAKFLLMRSVIDICQEVI 122
BACK_KLHL38 cd18476
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 38 (KLHL38); KLHL38 belongs ...
 134-226 4.31e-10

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 38 (KLHL38); KLHL38 belongs to the KLHL family. Its function remains unclear. The klhl38 gene has recently been identified as a possible diapause (a temporary arrest of development during early ontogeny) gene, as it is significantly up-regulated during diapause. It may also be involved in chicken preadipocyte differentiation.


Pssm-ID: 350551 [Multi-domain]  Cd Length: 99  Bit Score: 56.67  E-value: 4.31e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914 134 LDIDNCIGMHSFAEFHVCSELEKESRRILCSRFKEVWQQEEFLEISLEKFLFILSRKNLsVWKEEAILEPVIKWTAHDVE 213
Cdd:cd18476     1 LTPSNCLSMIRLSEILNCETLKKKAKDMALQCFPDVAASEDLKELCASELLDYLGDDEL-CGEEEQVFETLMVWIRHDPK 79

                          90
                  ....*....|...
gi 2772229914 214 NRVECLYNLLSYV 226
Cdd:cd18476    80 ARKGYIHDLFKKV 92
BTB_POZ cd01165
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 44-117 5.48e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.


Pssm-ID: 349496 [Multi-domain]  Cd Length: 79  Bit Score: 55.75  E-value: 5.48e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2772229914  44 SGIIFHCHRAVLAACSNYFKAMFTADMKEKFKSKIKLSGIHHDILEGLVNYAYTSQIEITKRNVQSLLEAADLL 117
Cdd:cd01165     6 EGEKFHVNKELLAQSSEYFRALFRGGFRESGQAEINLRDISPEDFRALLEFLYGGKRDLDASNLLELLEAANFL 79
BTB_POZ_BTBD17 cd18292
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-129 6.18e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349601 [Multi-domain]  Cd Length: 114  Bit Score: 56.91  E-value: 6.18e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  21 DFLDAFRTFYMDGLFTDITLQCpSGIIFHCHRAVLAACSNYFKAMFT-ADMKEKFKSKIKLsgiHHD-----ILEGLVNY 94
Cdd:cd18292     3 EFLQDIAQLYNNEELSDIVLRV-GGKVFHAHRLILAKSSDVFRVMLSnDWWSESKQSEIEL---VEDpecaaVFEKFLRY 78

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 2772229914  95 AYTSQIEITKRNVQSLLEAADLLQFLSVKKACEQF 129
Cdd:cd18292    79 LYTGQISVNLETALPLLMLADKYNVTDLKQLCVDF 113
BTB_POZ_ZBTB28_BCL6B cd18332
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 18-130 8.05e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell CLL/lymphoma 6 member B protein (BCL6B); BCL6B is also called Bcl6-associated zinc finger protein, zinc finger protein 62, or zinc finger and BTB domain-containing protein 28 (ZBTB28). It is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. BCL6B plays an important role as a potential tumor suppressor in gastric cancer; it is found preferentially methylated in gastric cancer. It also inhibits both colorectal cancer growth and hepatocellular carcinoma metastases. BCL6B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349641 [Multi-domain]  Cd Length: 114  Bit Score: 56.40  E-value: 8.05e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  18 HPVDFLDAFRTFYMDGLFTDITLQCpSGIIFHCHRAVLAACSNYFKAMFTADMKEKFKSKIKLSGIHHDILEGLVNYAYT 97
Cdd:cd18332     2 HSSDVLLNLNELRKRDILTDVTLLV-GGTPLRAHKAVLIACSGFFYSIFSGRVGEGVSVLTLPSGLEARGFQLLLDFMYT 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2772229914  98 SQIEITKRNVQSLLEAADLLQFLSVKKACEQFL 130
Cdd:cd18332    81 SRLPLTPRTVPAVLAAATYLQMEHVVETCRRFI 113
BTB_POZ_ZBTB24_ZNF450 cd18212
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 17-129 1.12e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 24 (ZBTB24); ZBTB24, also called zinc finger protein 450, functions as a transcription factor essentially involved in B-cell functions in humans. The loss-of-function mutations in ZBTB24 can cause ICF2 (immunodeficiency, centromeric instability and facial anomalies syndrome 2) with immunological characteristics of greatly reduced serum antibodies and circulating memory B cells. ZBTB24 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349521 [Multi-domain]  Cd Length: 118  Bit Score: 56.34  E-value: 1.12e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  17 SHPVDFLDAFRTFYMDGLFTDITLQCpSGIIFHCHRAVLAACSNYFKAMFTADMkEKFKSKIKLSGIHHDILEGLVNYAY 96
Cdd:cd18212     5 THKDTVLTNFEEQRKKDFLCDITLIV-ENVQFRAHKALLAASSEYFSMMFADEG-EVGQSIYMLEGMVAETFGALLEFIY 82

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2772229914  97 TSQIEITKRNVQSLLEAADLLQFLSVKKACEQF 129
Cdd:cd18212    83 TGCLQVGEKSLEQILATAQFLKVNDLVKAYSDY 115
Kelch smart00612
Kelch domain;
467-508 1.63e-09

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 53.33  E-value: 1.63e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 2772229914  467 KLYLVGGQTTI-----TECYDPEQNEWRETAPMMERRMECGAVIMNG 508
Cdd:smart00612   1 KIYVVGGFDGGqrlksVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
BTB_POZ_ZBTB5 cd18196
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 48-130 1.74e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 5 (ZBTB5); ZBTB5 is a POZ domain Kruppel-like zinc finger (POK) family transcription repressor of cell cycle arrest gene p21 and a potential proto-oncogene stimulating cell proliferation. ZBTB5 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349505 [Multi-domain]  Cd Length: 126  Bit Score: 55.82  E-value: 1.74e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  48 FHCHRAVLAACSNYFKAMFTADMKEKFKSKIKLSG--IHHDILEGLVNYAYTSQIEITKRNVQSLLEAADLLQFLSVKKA 125
Cdd:cd18196    33 FKAHRSVLAACSTHFRALFTVAEGDQTMNMIQLDSevVTAEAFAALIDMMYTSTLMLGESNVMDVLLAASHLHLNSVVKA 112


                  ....*
gi 2772229914 126 CEQFL 130
Cdd:cd18196   113 CKHYL 117
BACK_KLHL6 cd18446
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a ...
 134-235 2.58e-09

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation.


Pssm-ID: 350521 [Multi-domain]  Cd Length: 108  Bit Score: 54.78  E-value: 2.58e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914 134 LDIDNCIGMHSFAEFHVCSELEKESRRILCSRFKEVWQQEEFLEISLEKFLFILSRKNLSVWKEEAILEPVIKWTAHDVE 213
Cdd:cd18446     1 LHPENCVGILRLADAHSLESLKKQVQNYIIQNFSQVLNHEEFLELPVDILCHILKSDDLYVTEEEQVFETVMRWVRYKES 80

                          90       100
                  ....*....|....*....|...
gi 2772229914 214 NRVECLYNLLSYVNID-IDPVYL 235
Cdd:cd18446    81 ERLPLLPRVLENVRLPlLDPWYF 103
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 497-544 3.36e-09

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 52.61  E-value: 3.36e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 2772229914 497 RRMECGAVIMNGCIYVTGGYSysKGTYLQSIEKYDPDLNKWEIVGNLP 544
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFD--GNQSLNSVEVYDPETNTWSKLPSMP 46
BTB_POZ_calicin cd18307
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 35-129 3.73e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa. It contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349616 [Multi-domain]  Cd Length: 97  Bit Score: 54.04  E-value: 3.73e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  35 FTDITLQCPSgIIFHCHRAVLAACSNYFKAMFTADMKEKFKS---KIKLSGIHHDILEGLVNYAYTSQIEITKRNVQSLL 111
Cdd:cd18307     1 FCDVVISVDN-HSFAAHRNVLAAVSPFVKSLISSNDMKATDElsiTIDCDYLSPETVEQLLDYFYTGKIVISEKNVEDLL 79

                          90
                  ....*....|....*...
gi 2772229914 112 EAADLLQFLSVKKACEQF 129
Cdd:cd18307    80 KGAKYFNIPRLKDHCVDF 97
BACK_KLHL35 cd18474
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs ...
 134-211 3.91e-09

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs to the KLHL family. Its function remains unclear. Hypermethylation of KLHL35 is associated with hepatocellular carcinoma and abdominal aortic aneurysm.


Pssm-ID: 350549 [Multi-domain]  Cd Length: 79  Bit Score: 53.28  E-value: 3.91e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2772229914 134 LDIDNCIGMHSFAEFHVCSELEKESRRILCSRFKEVWQQEEFLEISLEKFLFILSRKNLSVWKEEAILEPVIKWTAHD 211
Cdd:cd18474     1 IGANNCLALLAAADALHCAPLQEHCIRVLLRDFAQAARHPSFLKLELQLVLELLADDSLAVRSEEVVLEAALRWVDAD 78
BTB_POZ_ZBTB46 cd18230
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 16-136 7.94e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 46 (ZBTB46); ZBTB46 is also called BTB-ZF protein expressed in effector lymphocytes (BZEL), BTB/POZ domain-containing protein 4 (BTBD4), or zinc finger protein 340 (ZNF340). It is a conventional dendritic cell (cDC) lineage specific transcription factor that acts as a negative regulator required to prevent activation of classical dendritic cells in the steady state. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349539 [Multi-domain]  Cd Length: 125  Bit Score: 53.91  E-value: 7.94e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  16 SSHPVDFLDAFRTFYMDGLFTDITLQCpSGIIFHCHRAVLAACSNYFKAMFTADMKEKFKSKIKlsgiHHDIL-----EG 90
Cdd:cd18230     2 TSHYRHLLRELNEQRQHGILCDVCIIV-EGKIFKAHKNVLLGSSRYFKTLYCQVQKTSDQATVT----HLDIVtaqgfKA 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 2772229914  91 LVNYAYTSQIEITKRNVQSLLEAADLLQFLSVKKACEQFLVRHLDI 136
Cdd:cd18230    77 IIDFMYSAHLALTSKNVIEVMSAASYLQMTDIVQACHNFIKAALDI 122
BTB_POZ_ABTB2_BPOZ2 cd18350
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 45-140 1.33e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2); ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins with various functions ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. It inhibits the aggregation of alpha-synuclein, with implications for Parkinson's disease. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. It is also involved in the growth suppressive effect of the phosphatase and tensin homolog (PTEN). It contains an ankyrin repeat, BTB/POZ, and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349659 [Multi-domain]  Cd Length: 134  Bit Score: 53.70  E-value: 1.33e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  45 GIIFHCHRAVLAACSNYFKAMFTADMKEKFKSK--IKLSGIHHDILEGLVNYAY---TSQIEITKRNVQSLLEAADLLQF 119
Cdd:cd18350    33 GKLFYAHKVLLVTASNRFKSLLTNKSEQESQGSktIEISDIKYHIFQMLMQYLYyggTESMEIPIADVLELLSAASLFQL 112

                          90       100
                  ....*....|....*....|.
gi 2772229914 120 LSVKKACEQFLVRHLDIDNCI 140
Cdd:cd18350   113 DALQRHCEILCSQTINLENAV 133
BTB_POZ_ZBTB35_ZNF131 cd18221
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 35-127 2.82e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131); ZNF131, also called zinc finger and BTB domain-containing protein 35 (ZBTB35), is a transcriptional activator implicated as a regulator of Kaiso-mediated biological processes. It regulates cell growth of developing and mature T cells. It inhibits estrogen signaling by suppressing estrogen receptor alpha homo-dimerization, and plays a role in breast cancer cell proliferation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349530 [Multi-domain]  Cd Length: 113  Bit Score: 51.93  E-value: 2.82e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  35 FTDITLQCpSGIIFHCHRAVLAACSNYFKAMFTADMKEKFkskIKLSGIHHDILEGLVNYAYTSQIEIT-KRNVQSLLEA 113
Cdd:cd18221    18 FTDITLIV-DGHQFKAHKAVLAACSQFFYKFFQDFTQEPL---VEIEGVSNMAFRHLIEFTYTAKLMVQgEEEANDVWKA 93

                          90
                  ....*....|....
gi 2772229914 114 ADLLQFLSVKKACE 127
Cdd:cd18221    94 AEYLQMQEAIKALE 107
BTB_POZ_BACH2 cd18278
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 7-130 2.87e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 2 (BACH2); BACH2, also called BTB-basic leucine zipper transcription factor 2, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). It is also a potent general repressor of effector differentiation in naive T cells. Moreover, BACH2 is required for pulmonary surfactant homeostasis and alveolar macrophage function. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349587 [Multi-domain]  Cd Length: 124  Bit Score: 52.26  E-value: 2.87e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914   7 EDYIYLFKDSSHPVDFLDAFRTFYMDGLFTDITLQCpSGIIFHCHRAVLAACSNYFKAMFTADMKE----KFKSKIKLSG 82
Cdd:cd18278     3 ESPMYVYESTVHCTNILLCLNDQRKQDILCDVTLIV-EGKEFRAHRAVLAACSEYFLQALVGQTENdlvvSLPEEVTARG 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2772229914  83 ihhdiLEGLVNYAYTSQIEITKRNVQSLLEAADLLQFLSVKKACEQFL 130
Cdd:cd18278    82 -----FGPLLQFAYTAKLLLSRENIQEVIRCAEFLRMHNLEDSCFRFL 124
BTB_POZ_KBTBD11 cd18275
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 44-139 3.22e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 11 (KBTBD11); KBTBD11 is also called chronic myelogenous leukemia-associated protein (CMLAP) or Kelch domain-containing protein 7B, or KLHDC7C. It is a BTB-Kelch family protein whose function remains unclear. A novel polymorphism rs11777210 in KBTBD11 is significantly associated with colorectal cancer risk. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349584 [Multi-domain]  Cd Length: 104  Bit Score: 51.72  E-value: 3.22e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  44 SGIIFHCHRAVLAACSNYFKAMFTADMkekfkskIKLSGIHHDILEGLVNYAYTSQIEITKRNVQSLLEAADLLQFLSVK 123
Cdd:cd18275    12 SGQRIRAHKSVLAAKSDYFRARLSRDI-------LKVKGLSYATLRLLVDYVYSGRMAVSKDNVVEVVAGARFLQMPCAA 84

                          90
                  ....*....|....*.
gi 2772229914 124 KACEQFLVRHLDIDNC 139
Cdd:cd18275    85 QCAVDAVRAQLCLGNC 100
BTB_POZ_ZBTB8A_BOZF1 cd18329
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 16-130 5.44e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8A (ZBTB8A); ZBTB8A, also called BTB/POZ and zinc-finger domain-containing factor or BTB/POZ and zinc-finger domains factor on chromosome 1 (BOZ-F1), is a novel proto-oncoprotein that stimulates cell proliferation. It binds to all the proximal GC boxes to repress transcription, and it inhibits p53 acetylation without affecting p53 stability. It may be involved in gastric adenocarcinoma cell differentiation, cancer invasion, and metastasis. ZBTB8A contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349638 [Multi-domain]  Cd Length: 116  Bit Score: 51.36  E-value: 5.44e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  16 SSHPVDFLDAFRTFYMDGLFTDITLQCpSGIIFHCHRAVLAACSNYFKAMFTADMKEKFKSKI-KLSGIHHDILEGLVNY 94
Cdd:cd18329     2 SSHQSRLLQQLDEQRKQELFCDCSILV-EGQVFKAHRNVLFASSGYFKMLLSQNAKETGQPTVaTFDVFSPDTFTIILDF 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2772229914  95 AYTSQIEITKRNVQSLLEAADLLQFLSVKKACEQFL 130
Cdd:cd18329    81 VYSGKLSLTSQNVIEVMSAASYLQMTDVISVCKTFI 116
BTB1_POZ_RhoBTB cd18299
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 24-130 8.70e-08

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349608 [Multi-domain]  Cd Length: 103  Bit Score: 50.29  E-value: 8.70e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  24 DAFRTFYMDGLFTDITLQCPSGIIFHCHRAVLAACSNYFKAMFTADMKEKFKSKIKLSGIHHdILEglvnYAYTSQIEIT 103
Cdd:cd18299     1 EDLRNLLHSPSCADVVFILQGGVRIFAHRIVLAAASSVFADLFLMMTVVTLDSDITPEAFRR-VLE----FLYTGVLDEN 75

                          90       100
                  ....*....|....*....|....*..
gi 2772229914 104 KRNVQSLLEAADLLQFLSVKKACEQFL 130
Cdd:cd18299    76 EDDLKELKDAAELLELFDLVMMCTNVL 102
BTB_POZ_ZBTB48_TZAP_KR3 cd18232
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 18-129 9.33e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in telomere zinc finger-associated protein (TZAP); TZAP is also called Krueppel-related zinc finger protein 3 (KR3), zinc finger and BTB domain-containing protein 48 (ZBTB48), or zinc finger protein 855 (ZNF855). It is a vertebrate telomere-binding protein involved in telomere length control. It directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. TZAP also acts as a transcription regulator that binds to promoter regions. It is a transcriptional activator of alternate reading frame (ARF) gene. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349541 [Multi-domain]  Cd Length: 108  Bit Score: 50.53  E-value: 9.33e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  18 HPVDFLDAFRTFYMDGLFTDITLQCpSGIIFHCHRAVLAACSNYFKAMFTADMKekfkSKIKLSGIHHDILEGLVNYAYT 97
Cdd:cd18232     1 HSVKVLQALNKQREEGQYCDATLDV-GGRVFKAHWSVLACCSHFFQSLYGDGTS----GSVVLPESFAEVFGLLLDFFYT 75

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2772229914  98 SQIEITKRNVQSLLEAADLLQFLSVKKACEQF 129
Cdd:cd18232    76 GELALTRENRDRVLLAAKELRVPEAVELCQRF 107
BTB_POZ_ZBTB27-like cd18215
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 18-129 1.43e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 proteins, BCL-6 and BCL-6B; This family includes B-cell lymphoma 6 proteins, BCL-6 and BCL-6B. BCL-6 is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. BCL-6B is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349524 [Multi-domain]  Cd Length: 113  Bit Score: 49.87  E-value: 1.43e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  18 HPVDFLDAFRTFYMDGLFTDITLQCpSGIIFHCHRAVLAACSNYFKAMFTADMKEKFkSKIKLSG-IHHDILEGLVNYAY 96
Cdd:cd18215     2 HASDVLLNLNRLRSRDILTDVVLVV-GREQFRAHKTVLMACSGLFYSIFTDQLKNNV-SVINLDPeIEPEGFRILLDFMY 79

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2772229914  97 TSQIEITKRNVQSLLEAADLLQFLSVKKACEQF 129
Cdd:cd18215    80 TSRLNLREGNIMAVMATAMYLQMEHVVDTCRKF 112
BTB_POZ_Rank-5 cd18303
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 34-140 1.76e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in rabankyrin-5 (Rank-5); Rank-5, also called ankyrin repeat and FYVE domain-containing protein 1 (ANKFY1) or ankyrin repeats hooked to a zinc finger motif (ANKHZN), is a Rab5 effector that regulates and coordinates different endocytic mechanisms. It contains an N-terminal BTB domain, followed by a BACK domain, several ankyrin (ANK) repeats and a C-terminal FYVE domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349612 [Multi-domain]  Cd Length: 120  Bit Score: 50.01  E-value: 1.76e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  34 LFTDITLQCpSGIIFHCHRAVLAACSNYFKAMFTADMKEkfkskIKLSGIHHDILEGLVNYAYTSQIEITKRNVQ--SLL 111
Cdd:cd18303    17 LYSDITIKL-ADKSIPAHKFVLAARSEKWSNENLASTNE-----LDLSDISYEVVLALLRWLYTDELDLTLDDEFllELM 90

                          90       100
                  ....*....|....*....|....*....
gi 2772229914 112 EAADLLQFLSVKKACEQFLVRHLDIDNCI 140
Cdd:cd18303    91 KAAKRFQLTDLVERCERALMSSVNVDNCI 119
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 358-402 2.14e-07

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 47.61  E-value: 2.14e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 2772229914 358 ARYYHCAVTLGGCVYALGGYRKGAPAEEAEFYDPLKEKWLPIANM 402
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSM 45
BACK_KLHL11 cd18451
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a ...
 134-217 3.83e-07

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation.


Pssm-ID: 350526 [Multi-domain]  Cd Length: 88  Bit Score: 48.03  E-value: 3.83e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914 134 LDIDNCIGMHSFAEFHVCSELEKESRRILCSRFKEVWQQEEFLEISLEKFLFILSRKNLSVWKEEAILEPVIKWTAHDVE 213
Cdd:cd18451     1 LNLSNCVAIHSLAHMYSLDQLALKAADMIRRNFHKVIQDEEFYTLPFHLVRDWLSDAEITVDSEEVLFEAVLKWVQRNAE 80


                  ....
gi 2772229914 214 NRVE 217
Cdd:cd18451    81 ERER 84
BTB_POZ_BPM_plant cd18280
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 36-130 4.97e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349589 [Multi-domain]  Cd Length: 121  Bit Score: 48.86  E-value: 4.97e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  36 TDITLQCpSGIIFHCHRAVLAACSNYFKAMFTADMKEKFKSKIKLSGIHHDILEGLVNYAYTSQI------------EIT 103
Cdd:cd18280    15 ADVTFNV-DGEKFRAHKLVLAARSPVFRSMLFGPMREENEGEIVIEDVEPPVFKALLHFIYKDELpddvepagsdssSLD 93

                          90       100
                  ....*....|....*....|....*..
gi 2772229914 104 KRNVQSLLEAADLLQFLSVKKACEQFL 130
Cdd:cd18280    94 TTMAQHLLAAADRYALERLRLLCESRL 120
BTB_POZ_BTBD1_2 cd18281
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 51-138 6.43e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD1 and BTBD2; This family includes BTB/POZ domain-containing proteins BTBD1 and BTBD2, both of which are BTB-domain-containing Kelch-like proteins that interact with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349590 [Multi-domain]  Cd Length: 127  Bit Score: 48.59  E-value: 6.43e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  51 HRAVLAACSNYFKAMFTADMKEKfKSKIKLSGIHHDILEGLVNYAYTSQIEITKRNVQSLLEAADLLQFLSVKKACEQFL 130
Cdd:cd18281    41 HKFVLSIGSAVFDAMFNGGMATT-SAEIELPDVEPAAFLALLRFLYSDEVQIGPETVMTTLYTAKKYAVPALESACVEFL 119


                  ....*...
gi 2772229914 131 VRHLDIDN 138
Cdd:cd18281   120 KKNLSSDN 127
BTB_POZ_ZBTB41 cd18226
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 35-117 1.14e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 41 (ZBTB41); ZBTB41, also called FRBZ1, may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349535 [Multi-domain]  Cd Length: 114  Bit Score: 47.49  E-value: 1.14e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  35 FTDITLQCpSGIIFHCHRAVLAACSNYFKAMFTadmKEKFKSKIKLSGIHHDILEGLVNYAYTSQIEITKRNVQSLLEAA 114
Cdd:cd18226    22 FCDLVITV-EGKEFSAHKVVVAVGSSYFHACLS---KNPNTDAVTLDHVSYSVFQHLLEFLYTSEFFVYENEIPLVLEAA 97


                  ...
gi 2772229914 115 DLL 117
Cdd:cd18226    98 KFL 100
BACK_KLHL27_IPP cd18466
BACK (BTB and C-terminal Kelch) domain found in intracisternal A particle-promoted polypeptide ...
 134-215 1.20e-06

BACK (BTB and C-terminal Kelch) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also termed Kelch-like protein 27 (KLHL27), is an actin-binding protein that may play a role in organizing the actin cytoskeleton.


Pssm-ID: 350541 [Multi-domain]  Cd Length: 103  Bit Score: 47.09  E-value: 1.20e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914 134 LDIDNCIGMHSFAEFHVCSELEKESRRILCSRFKEVWQQEEFLEISLEKFLFILSRKNLSVWKEEAILEPVIKWTAHDVE 213
Cdd:cd18466     1 IDPANCIGIFQFSEQIACHDLLEFTENYIHVHFLEVQSGEEFLGLTKDQLVKILRSEELSIEDEYQVFTAAMEWILKDVG 80


                  ..
gi 2772229914 214 NR 215
Cdd:cd18466    81 KR 82
BTB_POZ_ZBTB31_myoneurin cd18217
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 48-127 1.28e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in myoneurin; Myoneurin, also called zinc finger and BTB domain-containing protein 31 (ZBTB31), is a novel member of the BTB/POZ-zinc finger family highly expressed in the neuromuscular system and is associated with neuromuscular junctions during the late embryonic period. It may function as a synaptic gene regulator. Myoneurin contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349526 [Multi-domain]  Cd Length: 111  Bit Score: 47.44  E-value: 1.28e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  48 FHCHRAVLAACSNYFKAMF-TADMKEKFKSKIKLSGihhDILEGLVNYAYTSQIEITKRNVQSLLEAADLLQFLSVKKAC 126
Cdd:cd18217    30 FKAHRNVLAAFSEYFGAQYkDTEDNIVFLDQSQVSA---DGFQKLLEFIYTGNLNLDSWNVAEIHQAASYLGMEEVVAKC 106


                  .
gi 2772229914 127 E 127
Cdd:cd18217   107 K 107
BTB_POZ_BTBD3_6 cd18282
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 51-134 1.61e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD3 and BTBD6; This family includes BTB/POZ domain-containing proteins BTBD3 and BTBD6, both of which are BTB-domain-containing Kelch-like proteins. BTBD3 controls dendrite orientation toward active axons in mammalian neocortex. BTBD6 is required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349591 [Multi-domain]  Cd Length: 108  Bit Score: 47.00  E-value: 1.61e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  51 HRAVLAACSNYFKAMFTADMKEKfKSKIKLSGIHHDILEGLVNYAYTSQIEITKRNVQSLLEAADLLQFLSVKKACEQFL 130
Cdd:cd18282    26 HKYVLATGSSVFYAMFYGGLAEN-KNEIEIPDVEPAAFLNLLRYLYCDEIDLEPDTVLATLYAAKKYLVPHLARACVQFL 104


                  ....
gi 2772229914 131 VRHL 134
Cdd:cd18282   105 ETSL 108
BTB_POZ_ZBTB8 cd18199
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 45-130 1.65e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8 (ZBTB8); There are two ZBTB8 isoforms: ZBTB8A and ZBTB8B. ZBTB8A is a novel proto-oncoprotein that stimulates cell proliferation. ZBTB8B may be involved in transcriptional regulation. They both contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349508 [Multi-domain]  Cd Length: 113  Bit Score: 47.03  E-value: 1.65e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  45 GIIFHCHRAVLAACSNYFKAMFTADMKEKFK-SKIKLSGIHHDILEGLVNYAYTSQIEITKRNVQSLLEAADLLQFLSVK 123
Cdd:cd18199    27 GRIFKAHRNVLFASSGYFRMLLSHYIQDTGRpSTASFDVFSSDAFSIILDFVYSGKLSLTSQNVIEVMSAASYLQMTDVI 106


                  ....*..
gi 2772229914 124 KACEQFL 130
Cdd:cd18199   107 NVCKTFI 113
BTB_POZ_GCL cd18305
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 26-133 1.96e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein germ cell-less (GCL) and similar proteins; GCL proteins are nuclear envelope proteins highly conserved between the mammalian and Drosophila orthologs. Drosophila melanogaster GCL is a key regulator required for the specification of pole cells and primordial germ cell formation in embryos. Both, human germ cell-less protein-like 1 (GMCL1) and germ cell-less protein-like 2 (GMCL2), also called germ cell-less protein-like 1-like (GMCL1P1 or GMCL1L), may function in spermatogenesis. They may also be substrate-specific adaptors of E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. They contain BTB and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349614 [Multi-domain]  Cd Length: 115  Bit Score: 46.89  E-value: 1.96e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  26 FRTFYMDGLFTDITLqCPSGIIFHCHRAVLAACSnYFKAMFTADMKEKFKSKIKLSGIHHDILEGLVNYA----YTSQIE 101
Cdd:cd18305     6 YQTLFLNGENSDITI-CALGREWKLHKIYLCQSG-YFASMFSGSWKESKETVINLEIPDDNITVEALNVVfgslYRDEIE 83

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2772229914 102 ITKRNVQSLLEAADLLQFLSVKKACEQFLVRH 133
Cdd:cd18305    84 IKPSRVVSILAAATLLQLDGLIQQCSEVMKET 115
BTB_POZ_BTBD1 cd18346
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 51-138 1.97e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 1 (BTBD1); BTBD1, also called Hepatitis C virus NS5A-transactivated protein 8 or HCV NS5A-transactivated protein 8, is a BTB-domain-containing Kelch-like protein that is expressed in skeletal muscle and interacts with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. BTBD1 may serve as substrate-specific adaptor of an E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349655 [Multi-domain]  Cd Length: 133  Bit Score: 47.36  E-value: 1.97e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  51 HRAVLAACSNYFKAMFTADMKEKfKSKIKLSGIHHDILEGLVNYAYTSQIEITKRNVQSLLEAADLLQFLSVKKACEQFL 130
Cdd:cd18346    47 HRFVLAAGSAVFDAMFNGGMATT-SAEIELPDVEPAAFLALLRFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFL 125


                  ....*...
gi 2772229914 131 VRHLDIDN 138
Cdd:cd18346   126 TKHLRADN 133
BTB_POZ_ZBTB21_ZNF295 cd18209
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 18-112 5.64e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21); ZBTB21, also called zinc finger protein 295 (ZNF295), is a transcription repressor that acts in a selective manner on different promoters. It may be involved in the bi-directional control of gene expression in concert with another transcription factor ZFP161. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349518 [Multi-domain]  Cd Length: 112  Bit Score: 45.63  E-value: 5.64e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  18 HPVDFLDAFRTFYMDGLFTDITLqcpsgII----FHCHRAVLAACSNYFKAMFTADMKEKfKSKIKLSGIHHDILEGLVN 93
Cdd:cd18209     1 HAISLLSALNEERLKGQLCDVLL-----IVgdqkFRAHKNVLAASSEYFQSLFTEKENES-QSVFQLDFCEPDAFENVLN 74

                          90
                  ....*....|....*....
gi 2772229914  94 YAYTSQIEITKRNVQSLLE 112
Cdd:cd18209    75 YIYSSSLFVEKSSLAAVQE 93
BTB_POZ_ZBTB34 cd18220
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-130 6.58e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 34 (ZBTB34); ZBTB34 acts as a transcriptional regulator. It downregulates specificity protein (Sp) transcription factors Sp1, Sp3, and Sp4 in pancreatic cancer cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349529 [Multi-domain]  Cd Length: 120  Bit Score: 45.40  E-value: 6.58e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  23 LDAFRTFYMDGLFTDITLQCpSGIIFHCHRAVLAACSNYFKAMFTADMKekfkSKIKLSGIHH-DILEGLVNYAYTSQIE 101
Cdd:cd18220    13 LSQLNELRLQGKLCDIIVHI-QGQPFRAHKAVLAASSPYFRDHSALSTM----SGLSISVIKNpNVFEQLLSFCYTGRMS 87

                          90       100
                  ....*....|....*....|....*....
gi 2772229914 102 ITKRNVQSLLEAADLLQFLSVKKACEQFL 130
Cdd:cd18220    88 LQLKDVVSFLTAASFLQMQCVIDKCTQIL 116
BTB_POZ_ZBTB37 cd18222
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 31-130 9.61e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37); ZBTB37 may be involved in transcriptional regulation. It is differentially expressed in aryl hydrocarbon receptor (AhR)-KO mice compared with WT mice, and may potentially contribute to the aging phenotype of AhR-KO mice. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349531 [Multi-domain]  Cd Length: 123  Bit Score: 45.03  E-value: 9.61e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  31 MDGLFTDITLQCpSGIIFHCHRAVLAACSNYFK-AMFTADMkekfkSKIKLSGIHH-DILEGLVNYAYTSQIEITKRNVQ 108
Cdd:cd18222    21 MQGRLCDIVVNV-QGQSFRAHKVVLAASSPYFRdHMSLNEM-----STVSISVIKNpTVFEQLLSFCYTGRICLQLADII 94

                          90       100
                  ....*....|....*....|..
gi 2772229914 109 SLLEAADLLQFLSVKKACEQFL 130
Cdd:cd18222    95 SYLTAASFLQMQHIIDKCTQIL 116
BTB_POZ_BTBD11 cd18351
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 36-140 1.38e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 11 (BTBD11); BTBD11, also called ankyrin repeat and BTB/POZ domain-containing protein BTBD11, is a BTB-domain-containing protein. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349660 [Multi-domain]  Cd Length: 131  Bit Score: 44.97  E-value: 1.38e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  36 TDITLQCpSGIIFHCHRAVLAACSNYFKAMFTADMKEKfKSKIKLSGIHHDILEGLVNYAY---TSQIEITKRNVQSLLE 112
Cdd:cd18351    25 SDVTFLV-EGRPFYAHKVLLFTASPRFKALLSNKPSAE-NTCIEISYVKYHIFQLVMQYLYcggTESLLIKNNEIMELLS 102

                          90       100
                  ....*....|....*....|....*...
gi 2772229914 113 AADLLQFLSVKKACEQFLVRHLDIDNCI 140
Cdd:cd18351   103 AAKFFQLEALQRHCEIICAKSINTENCV 130
Kelch smart00612
Kelch domain;
370-416 1.42e-05

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 42.16  E-value: 1.42e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 2772229914  370 CVYALGGYRKGAPAEEAEFYDPLKEKWLPIANMIKGVGNATACVLHE 416
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
BTB_POZ_ZBTB27_BCL6 cd18331
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 34-130 1.61e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 protein (BCL-6); BCL-6 is also called B-cell lymphoma 5 protein (BCL-5), zinc finger and BTB domain-containing protein 27 (ZBTB27), protein LAZ-3, or zinc finger protein 51 (ZNF51). It is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. It represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' or indirectly by repressing the transcriptional activity of transcription factors. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349640 [Multi-domain]  Cd Length: 118  Bit Score: 44.46  E-value: 1.61e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  34 LFTDITLQCpSGIIFHCHRAVLAACSNYFKAMFTADMKEKFkSKIKLS-GIHHDILEGLVNYAYTSQIEITKRNVQSLLE 112
Cdd:cd18331    23 ILTDVVIVV-SREQFRAHKTVLMACSGLFYSIFTDQLKCNL-SVINLDpEINPEGFNILLDFMYTSRLNLREGNIMAVMA 100

                          90
                  ....*....|....*...
gi 2772229914 113 AADLLQFLSVKKACEQFL 130
Cdd:cd18331   101 TAMYLQMEHVVDTCRKFI 118
Kelch_4 pfam13418
Galactose oxidase, central domain;
497-545 1.72e-05

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 42.21  E-value: 1.72e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 2772229914 497 RRMECGAV-IMNGCIYVTGGYsYSKGTYLQSIEKYDPDLNKWEIVGNLPS 545
Cdd:pfam13418   1 PRAYHTSTsIPDDTIYLFGGE-GEDGTLLSDLWVFDLSTNEWTRLGSLPS 49
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 310-355 1.81e-05

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 41.83  E-value: 1.81e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 2772229914 310 RESYGVTCLGPNIYVTGGYrtDNIDALDTVWIYNSEGDEWTEGLPM 355
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGGF--DGNQSLNSVEVYDPETNTWSKLPSM 45
BTB_POZ_ZBTB33_KAISO cd18219
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-100 1.85e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kaiso; Kaiso, also called zinc finger and BTB domain-containing protein 33 (ZBTB33), is a DNA methylation-dependent transcriptional repressor that binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3'. It also binds to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349528 [Multi-domain]  Cd Length: 106  Bit Score: 43.67  E-value: 1.85e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  15 DSSHPVDFLDAFRTFYMDGLFTDITLqcpsgII----FHCHRAVLAACSNYFKAMFTADMKekfksKIKLSGIHHDILEG 90
Cdd:cd18219     1 DTQYSGSLLKSLNEQRGHGLFCDVTV-----IVedrkFRAHKNILSASSTYFHQLFSVAGQ-----VVELNFIRADIFAE 70

                          90
                  ....*....|
gi 2772229914  91 LVNYAYTSQI 100
Cdd:cd18219    71 ILNYIYSSKI 80
BTB_POZ_RCBTB1_2 cd18298
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 49-130 1.92e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2; The RCC1-related guanine nucleotide exchange factor (GEF) family includes RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2, both of which are chromosome condensation regulator-like guanine nucleotide exchange factors. They contain an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349607 [Multi-domain]  Cd Length: 108  Bit Score: 43.78  E-value: 1.92e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  49 HCHRAVLAACSNYFKAMFTADMKEKFKSKIKLSGIHHDILEGLVNYAYTSQIEITKRNVQSLLEAADLLQFLSVKKACEQ 128
Cdd:cd18298    25 YVHKAILKIRCEYFRSMFQSHWNEDDKNVIEIDQYSYPVYYAFLRYLYTDQVDLPPEDAIGLLDLANSYCEERLKKLCED 104


                  ..
gi 2772229914 129 FL 130
Cdd:cd18298   105 II 106
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 457-495 2.47e-05

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 41.44  E-value: 2.47e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 2772229914 457 YGLCSVPFENKLYLVGGQTTIT-----ECYDPEQNEWRETAPMM 495
Cdd:pfam01344   3 SGAGVVVVGGKIYVIGGFDGNQslnsvEVYDPETNTWSKLPSMP 46
BTB_POZ_BTBD6 cd18349
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 51-130 3.01e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 6 (BTBD6); BTBD6, also termed lens BTB domain protein, is a BTB-domain-containing Kelch-like protein required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349658 [Multi-domain]  Cd Length: 109  Bit Score: 43.43  E-value: 3.01e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  51 HRAVLAACSNYFKAMFTADMKEKfKSKIKLSGIHHDILEGLVNYAYTSQIEITKRNVQSLLEAADLLQFLSVKKACEQFL 130
Cdd:cd18349    27 HKYVLAVGSSVFYAMFYGDLAEV-KSEIHIPDVEPAAFLILLKYMYSDEIDLEADTVLATLYAAKKYIVPALAKACVNFL 105
Kelch_3 pfam13415
Galactose oxidase, central domain;
507-553 3.19e-05

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 41.51  E-value: 3.19e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 2772229914 507 NGCIYVTGGYSYSKGTYLQSIEKYDPDLNKWEIVGNLPSAMRSHGCV 553
Cdd:pfam13415   1 GDKLYIFGGLGFDGQTRLNDLYVYDLDTNTWTQIGDLPPPRSGHSAT 47
Kelch_3 pfam13415
Galactose oxidase, central domain;
319-365 3.41e-05

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 41.51  E-value: 3.41e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 2772229914 319 GPNIYVTGGYRTDNIDALDTVWIYNSEGDEWTEGLPMLNARYYHCAV 365
Cdd:pfam13415   1 GDKLYIFGGLGFDGQTRLNDLYVYDLDTNTWTQIGDLPPPRSGHSAT 47
BTB_POZ_ZBTB12 cd18203
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 35-135 3.81e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 12 (ZBTB12); ZBTB12, also called protein G10, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349512 [Multi-domain]  Cd Length: 122  Bit Score: 43.33  E-value: 3.81e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  35 FTDITLqCPSGIIFHCHRAVLAACSNYFKAMFTADMkekfKSKIKLSGIHHD-ILEGLVNYAYTSQIEITKRNVQSLLEA 113
Cdd:cd18203    25 FCDVTI-VADSLKFRGHKVVLAACSPFLRDQFLLNP----SSELQVSLMHSSrVVADLLLSCYTGALEFSVRDIVNYLTA 99

                          90       100
                  ....*....|....*....|..
gi 2772229914 114 ADLLQFLSVKKACEQFLVRHLD 135
Cdd:cd18203   100 ASYLQMEHVVEKCRGALSQFIE 121
BTB_POZ_ETO1-like cd18190
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 37-114 4.62e-05

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana ethylene-overproduction protein 1 (ETO1) and similar proteins; ETO1, also called protein ethylene overproducer 1, is an essential regulator of the ethylene pathway, which acts by regulating the stability of 1-aminocyclopropane-1-carboxylate synthase (ACS) enzymes. It may act as a substrate-specific adaptor that connects ACS enzymes, such as ACS5, to ubiquitin ligase complexes, leading to proteasomal degradation of ACS enzymes. The family also includes ETO1-like proteins 1 (EOL1) and 2 (EOL2). ETO1, EOL1, and EOL2 contain a BTB domain and tetratricopeptide (TPR) repeats. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349499 [Multi-domain]  Cd Length: 83  Bit Score: 42.12  E-value: 4.62e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  37 DITLqCPSGIIFHCHRAVLAACSNYFKAMFTADMKEKFKSKIKLSGIHHDI--LEGLVNYAYTSQIEIT-KRNVQSLLEA 113
Cdd:cd18190     1 DLVF-CVGGEKFCCVRKKIASLSRPFKAMLYGNFRESTSDCIDFEENGISIeaMRAVIDFSVTGRLDLFsVENVHEVLEL 79


                  .
gi 2772229914 114 A 114
Cdd:cd18190    80 A 80
BTB_POZ_ZBTB1 cd18192
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 46-127 4.64e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 1 (ZBTB1); ZBTB1 acts as a transcriptional repressor that represses cAMP-responsive element (CRE)-mediated transcriptional activation. It also has a role in translesion DNA synthesis, and is essential for lymphocyte development. ZBTB1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349501 [Multi-domain]  Cd Length: 114  Bit Score: 42.89  E-value: 4.64e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  46 IIFHCHRAVLAACSNYFKAMFTADmkEKFKSKIKLSG--IHHDILEGLVNYAYTSQIEITKRNVQSLLEAADLLQFLSVK 123
Cdd:cd18192    31 IYFQAHKAVLAACSSYFRMMFINH--QHTTAQLNLSNmkISAECFDLILQFMYLGKIMTAPSDFEQLKVAMNYLQLYYIP 108


                  ....
gi 2772229914 124 KACE 127
Cdd:cd18192   109 ECLE 112
BTB_POZ_ZBTB10 cd18201
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 33-130 4.92e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 10 (ZBTB10); ZBTB10, also called zinc finger protein RIN ZF, is an mRNA target of miR-27a and a transcriptional repressor of Specificity protein (Sp) expression. The microRNA-27a:ZBTB10-specificity protein pathway is involved in follicle stimulating hormone-induced VEGF, Cox2, and survivin expression in ovarian epithelial cancer cells. ZBTB10 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349510 [Multi-domain]  Cd Length: 122  Bit Score: 43.02  E-value: 4.92e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  33 GLFTDITLQCpSGIIFHCHRAVLAACSNYFKAMFTADMKEkfkSKIKLSGIHHDI--LEG---LVNYAYTSQIEITKRNV 107
Cdd:cd18201    19 GILCDVNIVV-SGKVFRAHKNILVAGSRFFKTLYCFTNKE---SCDQTTVTHLDVvaVQGfsvILDFMYSGNLVLTSQNA 94

                          90       100
                  ....*....|....*....|...
gi 2772229914 108 QSLLEAADLLQFLSVKKACEQFL 130
Cdd:cd18201    95 IEVMSVASYLQMTEVVQSCRNFI 117
BTB_POZ_ZBTB11 cd18202
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 18-128 5.17e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 11 (ZBTB11); ZBTB11 is a transcriptional repressor of TP53. It is critical for basal and emergency granulopoiesis. It regulates neutrophil development through its integrase-like zinc finger domain. ZBTB11 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349511 [Multi-domain]  Cd Length: 118  Bit Score: 42.92  E-value: 5.17e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  18 HPVDFLDAFRTFYMDGLFTDITLQCpSGIIFHCHRAVLAACSNYFKAMFTadmkEK-----FKSKIKLSGIHHDILEGLV 92
Cdd:cd18202     2 HGQTVLDQLNQQRLNNQFCDVTLLI-EGEEYKAHKSVLAANSEYFRELFI----EKgavssHEAVVDLSGFCKSSFLPLL 76

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2772229914  93 NYAYTSQIEITKRNVQSLLEAADLLQFLSVKKACEQ 128
Cdd:cd18202    77 EFAYTSELTFDFCSMAEVAMLARHLFMNEVLEICES 112
BTB_POZ_ZBTB8B cd18330
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 45-130 6.04e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8B (ZBTB8B); ZBTB8B may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349639 [Multi-domain]  Cd Length: 113  Bit Score: 42.61  E-value: 6.04e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  45 GIIFHCHRAVLAACSNYFKAMFTADMKEKFK-SKIKLSGIHHDILEGLVNYAYTSQIEITKRNVQSLLEAADLLQFLSVK 123
Cdd:cd18330    27 GRIFKAHRNILFANSGYFRALLIHYIQDSGRhSTASLDIVTSEAFSIILDFLYSGKLDLCSENVIEVMSAASYLQMTDVV 106


                  ....*..
gi 2772229914 124 KACEQFL 130
Cdd:cd18330   107 NFCKGYI 113
Kelch_6 pfam13964
Kelch motif;
498-544 6.94e-05

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 40.40  E-value: 6.94e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 2772229914 498 RMECGAVIMNGCIYVTGGYSYSkGTYLQSIEKYDPDLNKWEIVGNLP 544
Cdd:pfam13964   2 RTFHSVVSVGGYIYVFGGYTNA-SPALNKLEVYNPLTKSWEELPPLP 47
BTB1_POZ_ABTB1_BPOZ1 cd18295
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 21-115 7.63e-05

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349604 [Multi-domain]  Cd Length: 119  Bit Score: 42.24  E-value: 7.63e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  21 DFLDAF-RTFYMDGLFTDITLQCpSGIIFHCHRAVLAACSNYFKAMFTADMKEKFKSKIKLSGIHHDILEGLVNYAYTSQ 99
Cdd:cd18295     4 DYYDEFlRRLLEQGSYSDVTFNV-HGESFPAHRCILSARSPYFAEMFETKWKDKREINLKHPLVNPDAFRALLQYLYTGR 82

                          90
                  ....*....|....*.
gi 2772229914 100 IEITKRNVQSLLEAAD 115
Cdd:cd18295    83 LEIHVDDVEDCKRLAK 98
BTB_POZ_ZBTB42 cd18956
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 48-127 8.08e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 42 (ZBTB42); ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. It is enriched in skeletal muscles, especially at the neuromuscular junction. A ZBTB42 mutation has been identified to define a novel lethal congenital contracture syndrome (LCCS6), a lethal autosomal recessive form of arthrogryposis multiplex congenita (AMC). ZBTB42 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349737 [Multi-domain]  Cd Length: 129  Bit Score: 42.49  E-value: 8.08e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  48 FHCHRAVLAACSNYFKaMFTADMKEKFKSKIKLSGihhDILEG-----LVNYAYTSQIEITKRNVQSLLEAADLLQFLSV 122
Cdd:cd18956    35 FPAHRAVLAACSVYFH-LFYRDRPAGGRDTVRLNG---DIVTApafgrLLDFMYEGRLDLRSLPVEDVLAAASYLHMYDI 110


                  ....*
gi 2772229914 123 KKACE 127
Cdd:cd18956   111 VKVCK 115
BTB_POZ_BTBD14B_NAC1 cd18290
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 31-130 1.01e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 1 (NAC-1); NAC-1, also called BTB/POZ domain-containing protein 14B (BTBD14B), is a transcriptional repressor that contributes to tumor progression, tumor cell proliferation, and survival. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349599 [Multi-domain]  Cd Length: 123  Bit Score: 42.33  E-value: 1.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  31 MDGLFTDITLQCpSGIIFHCHRAVLAACSNYFKAMFTADMKEKFKSKiklSGIHHDILEGLVNYAYTSQIEITKRNVQSL 110
Cdd:cd18290    23 LQGLYCDVSVVV-KGHAFKAHRAVLAASSSYFRDLFNSSRSAVVELP---AAVQPQSFQQILSFCYTGRLSMNVGDQFLL 98

                          90       100
                  ....*....|....*....|.
gi 2772229914 111 LEAADLLQFLSV-KKACEQFL 130
Cdd:cd18290    99 MYTAGFLQIQEImEKGTEFFL 119
BTB1_POZ_KLHL33 cd18262
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 18-117 1.13e-04

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349571 [Multi-domain]  Cd Length: 101  Bit Score: 41.42  E-value: 1.13e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  18 HPVDFLDAFRTFYMDGLFTDITLQCpSGIIFHCHRAVLAACSnyfkAMFTADMKEKFKSKIKLSGIHHDI-LEGLVNYAY 96
Cdd:cd18262     1 HPSQFFGEAQRLREQRLLLDETVSV-GGRSYGVHSVILAAVS----SLFRERLLGSNGPLPPLSLEVTPVgWEAVLTFAY 75

                          90       100
                  ....*....|....*....|.
gi 2772229914  97 TSQIEITKRNVQSLLEAADLL 117
Cdd:cd18262    76 TGVLGRNPATVGDILVAAEAL 96
BTB_POZ_ZBTB3-like cd18194
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 48-127 1.19e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18, ZBTB42 and similar proteins; The family includes zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18 and ZBTB42. ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB18 is a sequence-specific transrepressor associated with heterochromatin. ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349503 [Multi-domain]  Cd Length: 128  Bit Score: 42.12  E-value: 1.19e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  48 FHCHRAVLAACSNYFKaMFTADMKEKFkskiKLSGIHHDILEG-----LVNYAYTSQIEITKRNVQSLLEAADLLQFLSV 122
Cdd:cd18194    35 FPAHRAVLASCSMYFH-LFYRDRLDKR----DLVRLNSDIVTApafglLLDFMYEGRLALRDLPVEDVLAAASYLHMYDI 109


                  ....*
gi 2772229914 123 KKACE 127
Cdd:cd18194   110 VKVCK 114
BTB_POZ_ZBTB18_2-like cd18325
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 48-127 1.40e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18.2 and similar proteins; This subfamily is composed of Xenopus laevis zinc finger and BTB domain-containing protein 18.2, encoded by the znf238.2.L gene, and similar proteins. Many proteins in this group are annotated as zinc finger and BTB domain-containing protein 42 (ZBTB42). However, characterized mammalian ZBTB42 does not belong to this subfamily. ZBTB18.2, like ZBTB18, functions as a transcriptional repressor that plays a role in various developmental processes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349634 [Multi-domain]  Cd Length: 128  Bit Score: 41.94  E-value: 1.40e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  48 FHCHRAVLAACSNYFKaMFTADMKEKfKSKIKLSGihhDILEG-----LVNYAYTSQIEITKRNVQSLLEAADLLQFLSV 122
Cdd:cd18325    35 FRAHRAVLASCSMYFH-LFYRDQLDK-RDIVHLNS---DIVTApafslLLEFMYEGKLEFSSLPVEDVLAAASYLHMYDI 109


                  ....*
gi 2772229914 123 KKACE 127
Cdd:cd18325   110 VKVCK 114
BTB_POZ_RCBTB1_CLLD7 cd18353
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 42-132 1.87e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 1 (RCBTB1); RCBTB1 is also called chronic lymphocytic leukemia deletion region gene 7 protein (CLLD7), CLL deletion region gene 7 protein, regulator of chromosome condensation and BTB domain-containing protein 1, or E4.5. It is a novel chromosome condensation regulator-like guanine nucleotide exchange factor that may be involved in cell cycle regulation by chromatin remodeling. It may also function as a tumor suppressor that regulates pathways of DNA damage/repair and apoptosis. RCBTB1 may also be a substrate adaptor for a cullin3 (CUL3) E3 ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Biallelic mutations in RCBTB1 may cause isolated and syndromic retinal dystrophy. It contains an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349662 [Multi-domain]  Cd Length: 117  Bit Score: 41.09  E-value: 1.87e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  42 CPSGIIFHCHRAVLAACSNYFKAMFTADMKEKFKSKIKLSGIHHDILEGLVNYAYTSQIEITKRNVQSLLEAADLLQFLS 121
Cdd:cd18353    26 RVDGKYIHVHKAVLKIRCEHFRTMFQSHWNEDMKEVIEIDQFSYPVYRAFLEYLYTDSVDLPPEDAIGLLDLATSYCENR 105

                          90
                  ....*....|.
gi 2772229914 122 VKKACEQFLVR 132
Cdd:cd18353   106 LKKLCQHIIKR 116
BTB_POZ_ZBTB6 cd18197
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 34-130 2.05e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 6 (ZBTB6); ZBTB6, also called zinc finger protein 482 (ZNF482) or zinc finger protein with interaction domain, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349506 [Multi-domain]  Cd Length: 116  Bit Score: 41.01  E-value: 2.05e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  34 LFTDITLQCpSGIIFHCHRAVLAACSNYFKAMFTADMKEKFKSKIKLSGihhDILEGLVNYAYTSQIEITKRNVQSLLEA 113
Cdd:cd18197    24 LFCDVSIYI-NDTEFHGHKVILAACSTFMRDQFLLNQSKQVRITILQSA---EVGRKLLLSCYTGALEVKKKELLKYLTA 99

                          90
                  ....*....|....*..
gi 2772229914 114 ADLLQFLSVKKACEQFL 130
Cdd:cd18197   100 ASYLQMVHIVEKCTEAL 116
BTB_POZ_ZBTB22_BING1 cd18210
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 31-130 2.66e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 22 (ZBTB22); ZBTB22, also called protein BING1 or zinc finger protein 297, may be involved in transcriptional regulation. Its gene, together with BING 3-5, TAPASIN, DAXX, RGL2, and HKE2, form a dense cluster at the centromeric end of the major histocompatibility complex class I region. ZBTB22 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349519 [Multi-domain]  Cd Length: 112  Bit Score: 40.59  E-value: 2.66e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  31 MDGLFTDITLQCpSGIIFHCHRAVLAACSNYFKAMFTAdmkeKFKSKIKLSGIHHDI-LEGLVNYAYTSQIEITKRNVQS 109
Cdd:cd18210    17 MEGKLCDISIHV-QGRVFRAHRAVLAASSPYFHDQVLL----KNMSSISLPGVMDPGaFESVLASAYTGKLTMLADEIVN 91

                          90       100
                  ....*....|....*....|.
gi 2772229914 110 LLEAADLLQFLSVKKACEQFL 130
Cdd:cd18210    92 YLTVGSVLQMWHIVDKCTELL 112
BTB_POZ_ZBTB4 cd18195
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 31-102 2.68e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 4 (ZBTB4); ZBTB4, also called KAISO-like zinc finger protein 1 (KAISO-L1), is a transcriptional repressor with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It can also bind specifically to a single methyl-CpG pair and can bind hemimethylated DNA but with a lower affinity compared to methylated DNA. ZBTB4 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349504 [Multi-domain]  Cd Length: 124  Bit Score: 41.03  E-value: 2.68e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  31 MDGLFTDITLqCPSGIIFHCHRAVLAACSNYFKAMFTADMKEKFKSK-------------IKLSGIHHDILEGLVNYAYT 97
Cdd:cd18195    14 LRGLFCDVTL-IAGDTKFRAHRSVLAASSPYFRELLSSPLPLGAAAVaaapgatqspervLELPGVKAGVFSDVLNFIYS 92


                  ....*
gi 2772229914  98 SQIEI 102
Cdd:cd18195    93 SRVAL 97
BTB_POZ_BTBD14A_NAC2 cd18289
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 33-118 3.08e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 2 (NAC-2); NAC-2, also called BTB/POZ domain-containing protein 14A (BTBD14A) or repressor with BTB domain and BEN domain (RBB), is a novel transcription repressor through its association with the NuRD complex. It recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349598 [Multi-domain]  Cd Length: 131  Bit Score: 40.78  E-value: 3.08e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  33 GLFTDITLQCpSGIIFHCHRAVLAACSNYFKAMFTADMKEKFKSKiklSGIHHDILEGLVNYAYTSQIEITKRNVQSLLE 112
Cdd:cd18289    27 GLYCDVSIVV-KGQAFKAHRAVLAASSLYFRDLFSGNSKSAFELP---ATVPPACFQQILSFCYTGKLTMAASEQLVVMY 102


                  ....*.
gi 2772229914 113 AADLLQ 118
Cdd:cd18289   103 TAGFLQ 108
BTB_POZ_ZBTB16_PLZF cd18205
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 18-130 3.34e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 16 (ZBTB16); ZBTB16 is also called promyelocytic leukemia zinc finger protein, zinc finger protein 145, or zinc finger protein PLZF. It is a DNA-binding transcription factor essential for undifferentiated cell maintenance. ZBTB16 also acts as a downstream transcriptional regulator of Osterix and can be useful as a late marker of osteoblastic differentiation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349514 [Multi-domain]  Cd Length: 107  Bit Score: 40.40  E-value: 3.34e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  18 HPVDFLDAFRTFYMDGLFTDITLQCPSGIiFHCHRAVLAACSNYFKAMFtadmkEKFKSKIKLSGIHHDILEGLVNYAYT 97
Cdd:cd18205     1 HPTGLLHKANQMRLAGTLCDVVIMVDSQE-FHAHRTVLACTSKMFEILF-----HRNSQHYTLDFLSPKTFQQILEYAYT 74

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2772229914  98 SQIEITKRNVQSLLEAADLLQFLSVKKACEQFL 130
Cdd:cd18205    75 ATLQAKVEDLDDLLYAAEILEIEYLEEQCLKIL 107
BTB_POZ_ZBTB25_ZNF46_KUP cd18213
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 46-97 3.46e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 25 (ZBTB25); ZBTB25, also called zinc finger protein 46 (ZNF46) or zinc finger protein KUP, is a transcription repressor that facilitates viral RNA transcription and replication. It interacts with viral RNA-dependent RNA polymerase (RdRp) proteins and modulates their transcription activity. It also functions as a viral RNA-binding protein, binding preferentially to the U-rich sequence within 5' UTR of vRNA. ZBTB25 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349522 [Multi-domain]  Cd Length: 128  Bit Score: 40.65  E-value: 3.46e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2772229914  46 IIFHCHRAVLAACSNYFKAMFTADMKEKFksKIKLSGIHHDILEGLVNYAYT 97
Cdd:cd18213    31 VYFKAHRAVLAAFSNYFKMIFIHQSSECI--KIQPTDIQPDIFSYLLHIMYT 80
BACK_calicin cd18503
BACK (BTB and C-terminal Kelch) domain found in calicin; Calicin is a basic cytoskeletal ...
 134-210 3.56e-04

BACK (BTB and C-terminal Kelch) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa.


Pssm-ID: 350578 [Multi-domain]  Cd Length: 78  Bit Score: 39.25  E-value: 3.56e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2772229914 134 LDIDNCIGMHSFAEFHVCSELEKESRRILCSRFKEVWQQEEFLEISLEKFLFILSRKNLSVWKEEAILEPVIKWTAH 210
Cdd:cd18503     1 LDRDNCLTALCLATTAGLKDLSDEIYDYIRDNFFDVSGTREFLQCPYDIFSRLLKDENLHVNNEDQVLLALLNWTEH 77
BTB_POZ_ZBTB3 cd18323
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 18-130 3.99e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 3 (ZBTB3); ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB3 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349632 [Multi-domain]  Cd Length: 128  Bit Score: 40.58  E-value: 3.99e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  18 HPVDFLDAFRTFYMDGLFTDITLQCPSgIIFHCHRAVLAACSNYFKaMFTADMKEKFkskiKLSGIHHDILEG-----LV 92
Cdd:cd18323     6 HSRHLLQSLREQRHQGFLCDCTVLVGS-TQFLAHRAVLASCSPFFH-MFYKEQLDKR----DLVCINNEIVTApafslLL 79

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 2772229914  93 NYAYTSQIEITKRNVQSLLEAADLLQFLSVKKACEQFL 130
Cdd:cd18323    80 EFMYEGRLSFNDTPVEDVLAAASYLHMNDIVKVCKKRL 117
BTB_POZ_BTBD2 cd18347
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 51-138 5.00e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 2 (BTBD2); BTBD2 is a BTB-domain-containing Kelch-like protein that interacts with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349656 [Multi-domain]  Cd Length: 127  Bit Score: 40.44  E-value: 5.00e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  51 HRAVLAACSNYFKAMFTADMKEKfKSKIKLSGIHHDILEGLVNYAYTSQIEITKRNVQSLLEAADLLQFLSVKKACEQFL 130
Cdd:cd18347    41 HRFVLAVGSAVFDAMFNGGMATT-STEIELPDVEPAAFLALLKFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFL 119


                  ....*...
gi 2772229914 131 VRHLDIDN 138
Cdd:cd18347   120 KKNLRADN 127
BTB_POZ_ZBTB18_RP58 cd18324
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 48-130 5.64e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18 (ZBTB18); ZBTB18 is also called 58 kDa repressor protein (RP58), transcriptional repressor RP58, translin-associated zinc finger protein 1 (TAZ-1), zinc finger protein 238 (ZNF238), or zinc finger protein C2H2-171. It is a sequence-specific transrepressor associated with heterochromatin. It plays a role in various developmental processes such as myogenesis and brain development. It specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. ZBTB18 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349633 [Multi-domain]  Cd Length: 147  Bit Score: 40.41  E-value: 5.64e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  48 FHCHRAVLAACSNYFKaMFTADMKEKfKSKIKLSGihhDILEG-----LVNYAYTSQIEITKRNVQSLLEAADLLQFLSV 122
Cdd:cd18324    35 FRAHRAVLASCSMYFH-LFYKDQLDK-RDIVHLNS---DIVTApafalLLEFMYEGKLQFKDLPIEDVLAAASYLHMYDI 109


                  ....*...
gi 2772229914 123 KKACEQFL 130
Cdd:cd18324   110 VKVCKKKL 117
BTB1_POZ_IBtk cd18301
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 37-98 6.98e-04

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349610 [Multi-domain]  Cd Length: 99  Bit Score: 39.19  E-value: 6.98e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2772229914  37 DITLQCpSGIIFHCHRAVLAACSNYFKAMFTADMKEKFKS----KIKLSGIHHDILEGLVNYAYTS 98
Cdd:cd18301    20 DVVFQV-GGKTFPAHKFILASRSDYFRKLFLSSLLTSEDAvgcdVVHIEKVPPEIFEQLLQFIYTD 84
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 408-450 7.01e-04

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 37.59  E-value: 7.01e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 2772229914 408 NATACVLHEVIYVIGGHCGYRGSCTydkVQSYNSDINEWSLIT 450
Cdd:pfam01344   4 GAGVVVVGGKIYVIGGFDGNQSLNS---VEVYDPETNTWSKLP 43
BTB2_POZ_LZTR1 cd18309
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 35-72 7.51e-04

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1); LZTR-1 is a golgi BTB-kelch protein that is degraded upon induction of apoptosis. It may also function as a transcriptional regulator that plays a crucial role in embryogenesis. Germline loss-of-function mutations in LZTR-1 predispose to an inherited disorder of multiple schwannomas. LZTR-1 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349618 [Multi-domain]  Cd Length: 126  Bit Score: 39.68  E-value: 7.51e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 2772229914  35 FTDITLQCpSGIIFHCHRAVLAACSNYFKAMFTADMKE 72
Cdd:cd18309    20 FCDITLLL-DGHPIPAHKAILAARCSYFEAMFRSFMPE 56
BTB_POZ_ZBTB2 cd18193
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-100 1.08e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 2 (ZBTB2); ZBTB2 is a POZ domain Kruppel-like zinc finger (POK) family transcription factor acting as a potent repressor of the ARF-HDM2-p53-p21 pathway, which is important in cell cycle regulation. It represses transcription of the ARF, p53, and p21 genes, but activates the HDM2 gene. ZBTB2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349502 [Multi-domain]  Cd Length: 115  Bit Score: 39.20  E-value: 1.08e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2772229914  23 LDAFRTFymdGLFTDITLQCpSGIIFHCHRAVLAACSNYFKAMFTADMKEKFksKIKLSGIHHDILEGLVNYAYTSQI 100
Cdd:cd18193    12 LNAQREF---GFLCDCTVAI-GDVYFKAHKSVLASFSNYFKMLFVHQTSECV--RLKPTDIQPDIFSYLLHLMYTGKM 83
Kelch_6 pfam13964
Kelch motif;
358-405 1.44e-03

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 36.93  E-value: 1.44e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2772229914 358 ARYYHCAVTLGGCVYALGGY-RKGAPAEEAEFYDPLKEKWLPIANMIKG 405
Cdd:pfam13964   1 PRTFHSVVSVGGYIYVFGGYtNASPALNKLEVYNPLTKSWEELPPLPTP 49
BTB_POZ_ZBTB38_CIBZ cd18223
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 31-114 1.63e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 38 (ZBTB38); ZBTB38, also termed CIBZ, is a transcriptional regulator with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3', as well as E-box elements (5'-CACGTG-3'). It can also bind specifically to a single methyl-CpG pair. ZBTB38 represses transcription in a methyl-CpG-dependent manner. It is a negative regulator of endoplasmic reticulum stress-associated apoptosis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349532 [Multi-domain]  Cd Length: 114  Bit Score: 38.62  E-value: 1.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  31 MDGLFTDITLQCPSgIIFHCHRAVLAACSNYFKAMFTADMKEKFKSKIKLSGIHHDILEGLVNYAYTSQIEITKRNVQSL 110
Cdd:cd18223    14 IQGILCDVTIVVED-TKFKAHKNVLAASSLYFKNAFSSQEIWISSHVLELPDLKAEVFAEILNFIYSSKVVVKRQETVTD 92


                  ....
gi 2772229914 111 LEAA 114
Cdd:cd18223    93 LVAA 96
BTB_POZ_NPR_plant cd18310
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 32-101 1.70e-03

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant regulatory proteins, NPR1-4, and similar proteins; NPR1 and NPR2 are essential for pathogenicity and the utilization of many nitrogen sources. NPR1 is also called nitrogen pathogenicity regulation protein NPR1, non-inducible immunity protein 1 (Nim1), nonexpresser of PR genes 1, or salicylic acid insensitive 1 (Sai1). It acts as a transcription coactivator that plays dual roles in regulating plant immunity. NPR3 and NPR4 are involved in negative regulation of defense responses against pathogens in plant. NPR proteins contain a BTB domain, DUF3420, ankyrin (ANK) repeats, and a conserved C-terminal domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349619 [Multi-domain]  Cd Length: 145  Bit Score: 39.21  E-value: 1.70e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2772229914  32 DGLFTDITLQCPSGIIFHCHRAVLAACSNYFKAMFTADMKEKFKSKIKLS--------GIHHDILEGLVNYAYTSQIE 101
Cdd:cd18310    15 DLFYSDAEIIVEGGRPVPVHRCILAARSPFFRDIFASAKAEGANTKPKLElrelipggIVGYDAFMLVLSYLYSGRLR 92
BTB_POZ_ZBTB43 cd18227
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 33-130 1.93e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 43 (ZBTB43); ZBTB43, also called zinc finger and BTB domain-containing protein 22B (ZBTB22b), zinc finger protein 297B (ZNF297B), or ZnF-x, may be involved in transcriptional regulation. It interacts with BDP1, a subunit of transcription factor IIIB (TFIIIB). Since BDP1 is essential in Pol III transcription, ZBTB43 may also regulate these transcriptional pathways. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349536 [Multi-domain]  Cd Length: 121  Bit Score: 38.38  E-value: 1.93e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  33 GLFTDITLQCpSGIIFHCHRAVLAACSNYfkamFTADMKEKFKSKIKLSGIHHD-ILEGLVNYAYTSQIEITKRNVQSLL 111
Cdd:cd18227    23 GQLCDISVVV-QGHLFRAHKAVLAASSPY----FCDQVLLKNSRRIVLPDVMNPrVFENILLSCYTGRLVLPAPEIVSYL 97

                          90
                  ....*....|....*....
gi 2772229914 112 EAADLLQFLSVKKACEQFL 130
Cdd:cd18227    98 TAASFLQMWHVVDKCTELL 116
BACK_KLHL9_13 cd18449
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL9 and KLHL13; KLHL9 ...
 136-224 1.97e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL9 and KLHL13; KLHL9 and KLHL13 (also termed BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis.


Pssm-ID: 350524 [Multi-domain]  Cd Length: 95  Bit Score: 37.79  E-value: 1.97e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914 136 IDNCIGMHSFAEFHVCSELEKESRRILCSRFKEVWQQEEFLEISLEKFLFILSRKNLSVWKEEAILEPVIKWTAHDvENR 215
Cdd:cd18449     3 LENCVEIGRIANTYHLTEVDKYVNDFILKNFPALLSTGDFVKLPFERLAFVLSSNSLKGCTELELFKAACRWLRHE-DDR 81


                  ....*....
gi 2772229914 216 VECLYNLLS 224
Cdd:cd18449    82 MQFAAKLME 90
BTB_POZ_ZBTB32_FAZF_TZFP cd18218
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 18-130 2.22e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 32 (ZBTB32); ZBTB32 is also called FANCC-interacting protein, fanconi anemia zinc finger protein (FAZF), testis zinc finger protein (TZFP), or zinc finger protein 538 (ZNF538). It is a DNA-binding transcription factor that binds to the 5'-TGTACAGTGT-3' core sequence. It acts as a transcription suppressor that controls T cell-mediated autoimmunity. ZBTB32 is essential for down-regulation of GATA3 via ZPO2; this promotes aggressive breast cancer development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349527 [Multi-domain]  Cd Length: 110  Bit Score: 38.00  E-value: 2.22e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  18 HPVDFLDAFRTFYMDGLFTDiTLQCPSGIIFHCHRAVLAACSNYFKAMFTADMKEKFKSkikLSGIHHDILEGLVNYAYT 97
Cdd:cd18218     1 HSDRLLHLAARLRPAGALCD-TLITVGSQEFPAHSLVLAGASQQLGRQLTNPNPGQWCL---GEGISPSTFKQLLDFVYG 76

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2772229914  98 SQIEITKRNVQSLLEAADLLQFLSVKKACEQFL 130
Cdd:cd18218    77 ESVEVQPGELRPLLEAARALEVESLEEACWRAL 109
PHA02713 PHA02713
hypothetical protein; Provisional
 439-557 2.29e-03

hypothetical protein; Provisional


Pssm-ID: 165086 [Multi-domain]  Cd Length: 557  Bit Score: 40.76  E-value: 2.29e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914 439 YNSDINEWSLITASPHPEYGLCSVPFENKLYLVGG----QTTITECY--DPEQNEWRETAPMMERRMECGAVIMNGCIYV 512
Cdd:PHA02713  277 YNINTMEYSVISTIPNHIINYASAIVDNEIIIAGGynfnNPSLNKVYkiNIENKIHVELPPMIKNRCRFSLAVIDDTIYA 356

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 2772229914 513 TGGysySKGTYLQ-SIEKYDPDLNKWEIVGNLPSAMRSHGcVCVYN 557
Cdd:PHA02713  357 IGG---QNGTNVErTIECYTMGDDKWKMLPDMPIALSSYG-MCVLD 398
BTB2_POZ_RHOBTB1 cd18358
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 33-158 2.42e-03

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1); RhoBTB1 is an atypical Rho family small guanosine triphosphatase (GTPase) and is a member of the RhoBTB subfamily, which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. The carboxyl terminal extension that harbors two BTB domains is capable of assembling cullin 3-dependent ubiquitin ligase complexes. RhoBTB1 functions as a tumor suppressor that regulates the integrity of the Golgi complex through the methyltransferase METTL7B. It also acts an adaptor of the Cullin-3-dependent E3 ubiquitin ligase complex. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349667 [Multi-domain]  Cd Length: 126  Bit Score: 38.41  E-value: 2.42e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  33 GLFTDITLQCPSGIIfHCHRAVLAACSNYFKAMFTADMKEKFKSKIKLSGIHHDILEGLVNYAYTSQIeitkrnvqSLLE 112
Cdd:cd18358    18 GTFSDVTFKLDDGTI-NAHKPLLICSCEWMAAMFGGSFIESANSEVVLPNISKVSMQAVLDYLYTKQL--------SPTA 88

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 2772229914 113 AADLLQFLSVkkaCEQFLVRHLDidncigmhSFAEFHVCSELEKES 158
Cdd:cd18358    89 DLDPLELIAL---ANRFCLPHLV--------ALTEQHAVQELTKAS 123
Kelch_2 pfam07646
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 497-543 2.52e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 462220 [Multi-domain]  Cd Length: 47  Bit Score: 36.16  E-value: 2.52e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 2772229914 497 RRMECGAVIMNGCIYVTGGYSYSKGTYLQSIEKYDPDLNKWEIVGNL 543
Cdd:pfam07646   1 PRYPHASSVPGGKLYVVGGSDGLGDLSSSDVLVYDPETNVWTEVPRL 47
BTB2_POZ_RHOBTB3 cd18360
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 27-134 2.98e-03

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 3 (RhoBTB3); RhoBTB3 is an atypical Rho family small guanosine triphosphatase (GTPase) and is a member of the RhoBTB subfamily, which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. The carboxyl terminal extension that harbors two BTB domains is capable of assembling cullin 3-dependent ubiquitin ligase complexes. RhoBTB3 is a Golgi-associated Rho-related ATPase that regulates the S/G2 transition of the cell cycle by targeting cyclin E for ubiquitylation. It is involved in vesicle trafficking and in targeting proteins for degradation in the proteasome. It binds directly to Rab9 GTPase and functions with Rab9 in protein transport from endosomes to the trans Golgi network. It also promotes proteasomal degradation of Hypoxia-inducible factor alpha (HIFalpha) through facilitating hydroxylation and suppresses the Warburg effect. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349669 [Multi-domain]  Cd Length: 110  Bit Score: 37.52  E-value: 2.98e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  27 RTFYMDGLFTDITLQCpSGIIFHCHRAVLAACSNYFKAMFTADMKEKFKSKIKLSGIHHDILEGLVNYAYT-SQIEITKR 105
Cdd:cd18360     2 GLFFNSPLLADVVFKI-QGTTVPAHRAVLVARCEVMAAMFNGNYAEAKSFLVPIYGVSKDTFLSFLEYLYTdSCCPASIL 80

                          90       100
                  ....*....|....*....|....*....
gi 2772229914 106 NVQSLLEAADLLQFLSVKKACEQFLVRHL 134
Cdd:cd18360    81 QAMALLICAEMYQVSRLQHICELYIITQL 109
BTB_POZ_ZBTB9 cd18200
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 18-130 3.12e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 9 (ZBTB9); ZBTB9 may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349509 [Multi-domain]  Cd Length: 111  Bit Score: 37.53  E-value: 3.12e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  18 HPVDFLDAFRTFYMDGLFTDITLQCpSGIIFHCHRAVLAACSNYF-KAMFTADmkekfKSKIKL-SGIHHDILEGLVNYA 95
Cdd:cd18200     1 YSSALLETLNKHRLEGKFCDLSVHV-QGRVFRAHKAVLAASSPYFhDKLLLND-----TNCLVLpSVIEAAAFENLLQLI 74

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 2772229914  96 YTSQIEITKRNVQSLLEAADLLQFLSVKKACEQFL 130
Cdd:cd18200    75 YSGRLTLCMDALPSHLLVASGLQMWQVVDRCSELL 109
BTB_POZ_ZBTB39 cd18224
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 16-126 3.56e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 39 (ZBTB39); ZBTB39 may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349533 [Multi-domain]  Cd Length: 123  Bit Score: 37.89  E-value: 3.56e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  16 SSHPVDFLDAFRTFYMDGLFTDITLQCpSGIIFHCHRAVLAACSNYFKAMFTADMKEKFKSKIkLSGIHHDILEGLVNYA 95
Cdd:cd18224     7 SDHPNNLLKELNKCRLSETMCDVTIVV-GNRSFAAHKAVLACAAGYFQKLFLSTELDVARTYV-VDFITPANFEKVLSFI 84

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2772229914  96 YTSQIEITKRNVQSLLEAADLLQFLSVKKAC 126
Cdd:cd18224    85 YTSELFTDLINVGVIYEVAEKLGMEDLLKAC 115
BTB_POZ_ZBTB30_HIC2 cd18334
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 47-132 3.68e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 2 protein (Hic-2); Hic-2 is also called HIC1-related gene on chromosome 22 protein (HRG22), Hic-3, or zinc finger and BTB domain-containing protein 30 (ZBTB30). It is a homolog of tumor suppressor Hic-1. It functions as a transcriptional regulator. It is a dosage-dependent regulator of cardiac development located within the distal 22q11 deletion syndrome region. Hic-2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349643 [Multi-domain]  Cd Length: 120  Bit Score: 37.64  E-value: 3.68e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  47 IFHCHRAVLAACSNYFKAMFTADMKEKFKSKIKLSGIHHDILEglvnYAYTSQI----EITKRNVQSLLEAADLLQFLSV 122
Cdd:cd18334    32 LFRAHKNILAASSMYFKSLVLHDNLINLDTDMVNPTVFRQILD----FIYTGKLltsdQPGEQNFNALLTAASYLQLHDL 107

                          90
                  ....*....|
gi 2772229914 123 KKACEQFLVR 132
Cdd:cd18334   108 AALCRKKLKR 117
BACK_KLHL26 cd18465
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is a ...
 134-215 4.16e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is a kelch family protein encoded by gene klhl26, which is regulated by p53 via fuzzy tandem repeats.


Pssm-ID: 350540  Cd Length: 97  Bit Score: 36.81  E-value: 4.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914 134 LDIDNCIGMHSFAEFHVCSELEKESRRILCSRFKEVWQQEEFLEISLEKFLFILSRKNLSVWKEEAILEPVIKWTAHDVE 213
Cdd:cd18465     1 MSVETCLNIGQMATTFSLASLKESVDAFTFRHFLQIAEEEDFLHLPLERLVFFLQSNKLKNCSEIDLFRAAIRWLQHDPS 80


                  ..
gi 2772229914 214 NR 215
Cdd:cd18465    81 RR 82
BACK_KLHL33 cd18472
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 33 (KLHL33); KLHL33 belongs ...
 134-207 4.18e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 33 (KLHL33); KLHL33 belongs to the KLHL family. Its function remains unclear. KLHL33 SNPs may be associated with prostate cancer risk.


Pssm-ID: 350547 [Multi-domain]  Cd Length: 75  Bit Score: 36.21  E-value: 4.18e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2772229914 134 LDIDNCIGMHSFAEFHVCSELEKESRRILCSRFKEVWQQEEFLEISLEKFLFILSRKNLSVWKEEAILEPVIKW 207
Cdd:cd18472     1 LSPANCLELWAFADAATLPRLAAAARAFALKHFAEVAASAAFLSLPLARLLELLRSDELEVAEEEAVFEAAVRW 74
BTB_POZ_KLHL42 cd18319
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 55-118 4.49e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 42 (KLHL42); KLHL42, also called Cullin-3-binding protein 9 (Ctb9) or Kelch domain-containing protein 5, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL42) E3 ubiquitin ligase complex mediates the ubiquitination and subsequent degradation of katanin (KATNA1). KLHL42 is involved in microtubule dynamics throughout mitosis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349628 [Multi-domain]  Cd Length: 93  Bit Score: 36.77  E-value: 4.49e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2772229914  55 LAACSNYFKAMFTADMKEKFKSKIKLSGIHHDILEGLVNYAYTSQIEITKRN----------VQSLLEAADLLQ 118
Cdd:cd18319    20 LIEQSDYFRALYRSGMRESGEEVVQLRGLSAPGLELVLDFINTSKVHESQGDstdtleenelLEDLVEAASFLQ 93
BTB_POZ_BTBD3 cd18348
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 51-138 4.64e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 3 (BTBD3); BTBD3 is a BTB-domain-containing Kelch-like protein that controls dendrite orientation toward active axons in the mammalian neocortex. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349657 [Multi-domain]  Cd Length: 131  Bit Score: 37.69  E-value: 4.64e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  51 HRAVLAACSNYFKAMFTADMKEKfKSKIKLSGIHHDILEGLVNYAYTSQIEITKRNVQSLLEAADLLQFLSVKKACEQFL 130
Cdd:cd18348    40 HKYVLAVGSSVFHAMFYGELAED-KDEIRIPDVEPAAFLAMLKYIYCDEIDLAADTVLATLYAAKKYIVPHLARACVNFL 118


                  ....*...
gi 2772229914 131 VRHLDIDN 138
Cdd:cd18348   119 ETSLSAKN 126
Kelch_6 pfam13964
Kelch motif;
461-498 4.75e-03

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 35.39  E-value: 4.75e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 2772229914 461 SVPFENKLYLVGGQTTIT------ECYDPEQNEWRETAPMMERR 498
Cdd:pfam13964   7 VVSVGGYIYVFGGYTNASpalnklEVYNPLTKSWEELPPLPTPR 50
BTB_POZ_ZBTB29-like cd18216
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 47-133 5.08e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer proteins, Hic-1 and Hic-2; The family includes hypermethylated in cancer proteins, Hic-1 and Hic-2. Hic-1 is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. Hic-2 is a homolog of tumor suppressor Hic-1 that functions as a transcriptional regulator. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349525 [Multi-domain]  Cd Length: 118  Bit Score: 37.13  E-value: 5.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  47 IFHCHRAVLAACSNYFKAMFTADmkekfkSKIKLS--GIHHDILEGLVNYAYTSQI---EITKRNVQSLLEAADLLQFLS 121
Cdd:cd18216    31 LFRAHKNVLAASSGYFKSLVLHD------NLIHLDqdMVSPTVFQQILDFIYTGKLldsLFEEPNLSEVLAAANYLQLPD 104

                          90
                  ....*....|..
gi 2772229914 122 VKKACEQFLVRH 133
Cdd:cd18216   105 LAALCRSKLKRG 116
BTB_POZ_ZBTB29_HIC1 cd18333
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 47-133 8.97e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 1 protein (Hic-1); Hic-1, also called zinc finger and BTB domain-containing protein 29 (ZBTB29), is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. It may act as a tumor suppressor, and is involved in regulatory loops modulating P53-dependent and E2F1-dependent cell survival, growth control, and stress responses. It also regulates intestinal immunity and homeostasis. Hic-1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349642 [Multi-domain]  Cd Length: 121  Bit Score: 36.42  E-value: 8.97e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2772229914  47 IFHCHRAVLAACSNYFKAMFTADMKEKFKSKIKLSGIHHDILEglvnYAYTSQI----EITKRNVQSLLEAADLLQFLSV 122
Cdd:cd18333    32 LFRAHKNILAASSVYLKSLVVHDNLINLDHEMVSPGIFRLILD----YIYTGRLsegdPGSEQNLGAVLAAASYLQIPDL 107

                          90
                  ....*....|.
gi 2772229914 123 KKACEQFLVRH 133
Cdd:cd18333   108 VALCKKKLKRN 118
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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