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Conserved domains on  [gi|2509786629|ref|NP_001408680|]
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pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial-like [Homo sapiens]

Protein Classification

FAD-dependent oxidoreductase( domain architecture ID 11429831)

FAD-dependent oxidoreductase containing a GcvT (glycine cleavage system T) domain such as sarcosine dehydrogenase and dimethylglycine dehydrogenase

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GcvT COG0404
Glycine cleavage system protein T (aminomethyltransferase) [Amino acid transport and ...
 454-852 9.41e-86

Glycine cleavage system protein T (aminomethyltransferase) [Amino acid transport and metabolism]; Glycine cleavage system protein T (aminomethyltransferase) is part of the Pathway/BioSystem: Glycine cleavage


:

Pssm-ID: 440173 [Multi-domain]  Cd Length: 372  Bit Score: 278.50  E-value: 9.41e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2509786629 454 GRQLRTSPLYDRLDAQGARWMEKHGFERPKYFVppdkdllaleqsktfykpdwfDIVESEVKCCKEAVCVIDMSSFTKFE 533
Cdd:COG0404     1 FRPLRRTPLHDRHVALGAKFVDFGGWEMPVQYP---------------------GGVIAEHLAVREAVGLFDVSHMGKIE 59

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2509786629 534 ITstGDQALEVLQYLFSNDLDV-PVGHIVHTGMLNEGGGYENDCSIARLNKRSFFMISPTDQQVHCWAWLKKHMPKDSNL 612
Cdd:COG0404    60 VT--GPDAAAFLDRLVTNDVSKlKPGRARYTLMLNEDGGIIDDLTVYRLGEDRFLLVVNAANAAKDLAWLEEHLPPDFDV 137

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2509786629 613 LLEDVTWKYTALNLIGPRAVDVLSELsyAPMTPDHFPSLFCKEMSVGYAKgIRVMSMTHTGEPGFMLYIPIEYALHVYNE 692
Cdd:COG0404   138 TITDVTDDWALLAVQGPKAREVLAKL--TDADLSALPFMSFREGTVAGVP-VRVSRTGYTGEDGFEIYVPAEDAEALWDA 214

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2509786629 693 VMSVGQKYGIRNAGYYALRSLRIEKFFAFWGQDINNLTTPLECGRESRVKLEKGmDFIGRDALLQQKQNGVYKRLTMFIL 772
Cdd:COG0404   215 LLEAGEEFGVKPCGLGARDTLRLEAGYPLYGHELDETTTPLEAGLGWAVKLDKG-DFIGKEALLRQKEEGPRRKLVGLEL 293

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2509786629 773 DDHDSdldlwPWWGEPIYRNGQYVGKTTSSAYSYSLERHVCLGFVHNFSEDTGEeqvvtadfinrgEYEIDIAGYRFQAK 852
Cdd:COG0404   294 DGRGV-----PRAGAPVLADGEVVGEVTSGTFSPTLGKSIALAYVPAGLARPGT------------ELEVEIRGKRVPAE 356
DadA COG0665
Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];
41-419 5.61e-70

Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];


:

Pssm-ID: 440429 [Multi-domain]  Cd Length: 364  Bit Score: 235.95  E-value: 5.61e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2509786629  41 TQAQVVVCGGGITGTSVAHHQSKMGWkDIVLLEQGRLAAGSTRFCAGILST---ARHLTIEQKMADYSNKLYHQLEQETG 117
Cdd:COG0665     1 ATADVVVIGGGIAGLSTAYHLARRGL-DVTVLERGRPGSGASGRNAGQLRPglaALADRALVRLAREALDLWRELAAELG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2509786629 118 IQTGYTRTGSIFLAQTQDRLISLKRINAGLNVIGIPSEIISPKKVAELHHLLNVHDLVGAMHVPEDAVVSSADVALALAS 197
Cdd:COG0665    80 IDCDFRRTGVLYLARTEAELAALRAEAEALRALGLPVELLDAAELREREPGLGSPDYAGGLYDPDDGHVDPAKLVRALAR 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2509786629 198 AASQNGVQVYDRTSVLHVMVKKGQVTGVETDKGQIECQYFVNCAGQWAYELGlsNEEPVSIPLHACEHFYLLTRPLETPL 277
Cdd:COG0665   160 AARAAGVRIREGTPVTGLEREGGRVTGVRTERGTVRADAVVLAAGAWSARLL--PMLGLRLPLRPVRGYVLVTEPLPDLP 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2509786629 278 qssTPTIVDaDGRIYIRNWQGG--ILSGGFEKNPkpiftegknqleiQNLQEDWDHFEPLLSSLLRRMPELETLEIMKLV 355
Cdd:COG0665   238 ---LRPVLD-DTGVYLRPTADGrlLVGGTAEPAG-------------FDRAPTPERLEALLRRLRRLFPALADAEIVRAW 300

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2509786629 356 NCPETFTPDMRCIMGESPAVQGYFVLAGMNSAGLSFGGGAGKYLAEWMVHGYPSENVWELDLKR 419
Cdd:COG0665   301 AGLRPMTPDGLPIIGRLPGAPGLYVATGHGGHGVTLAPAAGRLLADLILGGEPPLDLAPFSPDR 364
FAO_M pfam16350
FAD dependent oxidoreductase central domain; This domain occurs in several FAD dependent ...
 405-460 7.56e-16

FAD dependent oxidoreductase central domain; This domain occurs in several FAD dependent oxidoreductases: Sarcosine dehydrogenase, Dimethylglycine dehydrogenase and Dimethylglycine dehydrogenase. It is situated between the DAO domain (pfam01266) and the GCV_T domain (pfam01571).


:

Pssm-ID: 465100  Cd Length: 56  Bit Score: 72.10  E-value: 7.56e-16
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2509786629 405 HGYPSENVWELDLKRFGALQSSRTFLRHRVMEVMPLMYDLKVPRWDFQTGRQLRTS 460
Cdd:pfam16350   1 DGEPPIDLWECDIRRFGPHQNNREYLRERVAENYGEVYDIHHPNEEREAGRPLRTS 56
 
Name Accession Description Interval E-value
GcvT COG0404
Glycine cleavage system protein T (aminomethyltransferase) [Amino acid transport and ...
 454-852 9.41e-86

Glycine cleavage system protein T (aminomethyltransferase) [Amino acid transport and metabolism]; Glycine cleavage system protein T (aminomethyltransferase) is part of the Pathway/BioSystem: Glycine cleavage


Pssm-ID: 440173 [Multi-domain]  Cd Length: 372  Bit Score: 278.50  E-value: 9.41e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2509786629 454 GRQLRTSPLYDRLDAQGARWMEKHGFERPKYFVppdkdllaleqsktfykpdwfDIVESEVKCCKEAVCVIDMSSFTKFE 533
Cdd:COG0404     1 FRPLRRTPLHDRHVALGAKFVDFGGWEMPVQYP---------------------GGVIAEHLAVREAVGLFDVSHMGKIE 59

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2509786629 534 ITstGDQALEVLQYLFSNDLDV-PVGHIVHTGMLNEGGGYENDCSIARLNKRSFFMISPTDQQVHCWAWLKKHMPKDSNL 612
Cdd:COG0404    60 VT--GPDAAAFLDRLVTNDVSKlKPGRARYTLMLNEDGGIIDDLTVYRLGEDRFLLVVNAANAAKDLAWLEEHLPPDFDV 137

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2509786629 613 LLEDVTWKYTALNLIGPRAVDVLSELsyAPMTPDHFPSLFCKEMSVGYAKgIRVMSMTHTGEPGFMLYIPIEYALHVYNE 692
Cdd:COG0404   138 TITDVTDDWALLAVQGPKAREVLAKL--TDADLSALPFMSFREGTVAGVP-VRVSRTGYTGEDGFEIYVPAEDAEALWDA 214

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2509786629 693 VMSVGQKYGIRNAGYYALRSLRIEKFFAFWGQDINNLTTPLECGRESRVKLEKGmDFIGRDALLQQKQNGVYKRLTMFIL 772
Cdd:COG0404   215 LLEAGEEFGVKPCGLGARDTLRLEAGYPLYGHELDETTTPLEAGLGWAVKLDKG-DFIGKEALLRQKEEGPRRKLVGLEL 293

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2509786629 773 DDHDSdldlwPWWGEPIYRNGQYVGKTTSSAYSYSLERHVCLGFVHNFSEDTGEeqvvtadfinrgEYEIDIAGYRFQAK 852
Cdd:COG0404   294 DGRGV-----PRAGAPVLADGEVVGEVTSGTFSPTLGKSIALAYVPAGLARPGT------------ELEVEIRGKRVPAE 356
GCV_T pfam01571
Aminomethyltransferase folate-binding domain; This is a family of glycine cleavage T-proteins, ...
 463-736 4.15e-84

Aminomethyltransferase folate-binding domain; This is a family of glycine cleavage T-proteins, part of the glycine cleavage multienzyme complex (GCV) found in bacteria and the mitochondria of eukaryotes. GCV catalyzes the catabolism of glycine in eukaryotes. The T-protein is an aminomethyl transferase.


Pssm-ID: 460255  Cd Length: 254  Bit Score: 269.84  E-value: 4.15e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2509786629 463 YDRLDAQGARWMEKHGFERPKYFVPPDKDllaleqsktfykpdwfdiveSEVKCCKEAVCVIDMSSFTKFEITstGDQAL 542
Cdd:pfam01571   1 YDRHVALGAKFVEFAGWEMPVQYGSNGIL--------------------AEHRAVREAAGLFDVSHMGKIEVS--GPDAA 58

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2509786629 543 EVLQYLFSNDLD-VPVGHIVHTGMLNEGGGYENDCSIARLNKRSFFMISPTDQQVHCWAWLKKHMPKDsNLLLEDVTWKY 621
Cdd:pfam01571  59 AFLQRLTTNDVSkLKPGRATYTLMLNERGGVIDDLTVYRLGDDHFLLVVNAANREKDLAWLRKHAEKL-DVVVVDVTDDY 137

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2509786629 622 TALNLIGPRAVDVLSELSYAPMTPDhFPSLFCKEMSVGYAKgIRVMSMTHTGEPGFMLYIPIEYALHVYNEVMSVGQKYG 701
Cdd:pfam01571 138 ALLALQGPKAREVLEKLTDGDLLEA-LPFFSFREIEIGGVP-VRVSRTGYTGEDGFEIYVPAEDAVELWEALLEAGAELG 215

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 2509786629 702 IRNAGYYALRSLRIEKFFAFWGQDINNLTTPLECG 736
Cdd:pfam01571 216 LRPAGLGARDSLRLEAGLPLYGHDLDEETTPLEAG 250
DadA COG0665
Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];
41-419 5.61e-70

Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];


Pssm-ID: 440429 [Multi-domain]  Cd Length: 364  Bit Score: 235.95  E-value: 5.61e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2509786629  41 TQAQVVVCGGGITGTSVAHHQSKMGWkDIVLLEQGRLAAGSTRFCAGILST---ARHLTIEQKMADYSNKLYHQLEQETG 117
Cdd:COG0665     1 ATADVVVIGGGIAGLSTAYHLARRGL-DVTVLERGRPGSGASGRNAGQLRPglaALADRALVRLAREALDLWRELAAELG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2509786629 118 IQTGYTRTGSIFLAQTQDRLISLKRINAGLNVIGIPSEIISPKKVAELHHLLNVHDLVGAMHVPEDAVVSSADVALALAS 197
Cdd:COG0665    80 IDCDFRRTGVLYLARTEAELAALRAEAEALRALGLPVELLDAAELREREPGLGSPDYAGGLYDPDDGHVDPAKLVRALAR 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2509786629 198 AASQNGVQVYDRTSVLHVMVKKGQVTGVETDKGQIECQYFVNCAGQWAYELGlsNEEPVSIPLHACEHFYLLTRPLETPL 277
Cdd:COG0665   160 AARAAGVRIREGTPVTGLEREGGRVTGVRTERGTVRADAVVLAAGAWSARLL--PMLGLRLPLRPVRGYVLVTEPLPDLP 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2509786629 278 qssTPTIVDaDGRIYIRNWQGG--ILSGGFEKNPkpiftegknqleiQNLQEDWDHFEPLLSSLLRRMPELETLEIMKLV 355
Cdd:COG0665   238 ---LRPVLD-DTGVYLRPTADGrlLVGGTAEPAG-------------FDRAPTPERLEALLRRLRRLFPALADAEIVRAW 300

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2509786629 356 NCPETFTPDMRCIMGESPAVQGYFVLAGMNSAGLSFGGGAGKYLAEWMVHGYPSENVWELDLKR 419
Cdd:COG0665   301 AGLRPMTPDGLPIIGRLPGAPGLYVATGHGGHGVTLAPAAGRLLADLILGGEPPLDLAPFSPDR 364
DAO pfam01266
FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: ...
 45-402 3.84e-52

FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: Glycerol-3-phosphate dehydrogenase EC:1.1.99.5, Sarcosine oxidase beta subunit EC:1.5.3.1, D-alanine oxidase EC:1.4.99.1, D-aspartate oxidase EC:1.4.3.1.


Pssm-ID: 426168 [Multi-domain]  Cd Length: 339  Bit Score: 185.68  E-value: 3.84e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2509786629  45 VVVCGGGITGTSVAHHQSKMGWkDIVLLEQG-RLAAGSTRFCAGILSTARHLTIEQ---KMADYSNKLYHQLEQETGIQT 120
Cdd:pfam01266   2 VVVIGGGIVGLSTAYELARRGL-SVTLLERGdDPGSGASGRNAGLIHPGLRYLEPSelaRLALEALDLWEELEEELGIDC 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2509786629 121 GYTRTGSIFLAQTQDRlISLKRINAGLNVIGIPSEIISPKKVAELHHLLNvhDLVGAMHVPEDAVVSSADVALALASAAS 200
Cdd:pfam01266  81 GFRRCGVLVLARDEEE-EALEKLLAALRRLGVPAELLDAEELRELEPLLP--GLRGGLFYPDGGHVDPARLLRALARAAE 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2509786629 201 QNGVQVYDRTSVLHVmVKKGQVTGVETDkGQIECqyFVNCAGQWAYELGLSneePVSIPLHACEHFYLLTRPL-ETPLQS 279
Cdd:pfam01266 158 ALGVRIIEGTEVTGI-EEEGGVWGVVTT-GEADA--VVNAAGAWADLLALP---GLRLPVRPVRGQVLVLEPLpEALLIL 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2509786629 280 STPTIVDADGRIYIRN-WQGGILSGGFEknpkpiFTEGKNQLEIqnlqeDWDHFEPLLSSLLRRMPELETLEimklvncp 358
Cdd:pfam01266 231 PVPITVDPGRGVYLRPrADGRLLLGGTD------EEDGFDDPTP-----DPEEIEELLEAARRLFPALADIE-------- 291

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*....
gi 2509786629 359 ETF-----TPDMRCIMGEsPAVQGYFVLAGMNSAGLSFGGGAGKYLAEW 402
Cdd:pfam01266 292 RAWaglrpLPDGLPIIGR-PGSPGLYLATGHGGHGLTLAPGIGKLLAEL 339
gcvT PRK00389
glycine cleavage system aminomethyltransferase GcvT;
457-838 3.12e-38

glycine cleavage system aminomethyltransferase GcvT;


Pssm-ID: 234742 [Multi-domain]  Cd Length: 359  Bit Score: 146.42  E-value: 3.12e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2509786629 457 LRTSPLYDRLDAQGARWMEKHGFERP-KYfvppdkdllaleQSktfykpdwfdIVEsEVKCCKEAVCVIDMSSFTKFEIT 535
Cdd:PRK00389    2 LKRTPLYDLHVALGAKMVDFGGWEMPvQY------------GS----------IIE-EHHAVRTDAGLFDVSHMGEVDVT 58

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2509786629 536 stGDQALEVLQYLFSNDLD-VPVGHIVHTGMLNEGGGYENDCSIARLNKRSFFMI--SPTDQQVhcWAWLKKHMpKDSNL 612
Cdd:PRK00389   59 --GPDALAFLQYLLANDVSkLKPGKAQYTCMLNEDGGVIDDLIVYKLSEDEYLLVvnAANREKD--LAWIKSHA-AGFGV 133

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2509786629 613 LLEDVTWKYTALNLIGPRAVDVLSELSYAPMtpDHFPSLFCKEMSVGYAKGIRVmSMT-HTGEPGFMLYIPIEYALHVYN 691
Cdd:PRK00389  134 EVTDRSDDLAMIAVQGPKAREKLQKLTDADL--SELKPFFGAQGAEVGGGDVLV-ARTgYTGEDGFEIYLPAEDAEALWD 210

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2509786629 692 EVMSVGqkygIRNAGYYALRSLRIEKFFAFWGQDINNLTTPLECGRESRVKLEKGMDFIGRDALLQQKQNGVYKRLTMF- 770
Cdd:PRK00389  211 ALLEAG----VKPCGLGARDTLRLEAGMPLYGQDMDETITPLEAGLGWTVKLEEKRDFIGREALEAQKEAGVERKLVGLe 286

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2509786629 771 -----IlddhdsdldlwPWWGEPIYRNGQYVGKTTSSAYSYSLERHVCLGFVhnfSEDTGEE------------QVVTAD 833
Cdd:PRK00389  287 leergI-----------PRHGYPVLADGEEIGEVTSGTFSPTLGKSIALAYV---PAGVGDEveveirgkqvpaKVVKPP 352


                  ....*
gi 2509786629 834 FINRG 838
Cdd:PRK00389  353 FVRRG 357
FAO_M pfam16350
FAD dependent oxidoreductase central domain; This domain occurs in several FAD dependent ...
 405-460 7.56e-16

FAD dependent oxidoreductase central domain; This domain occurs in several FAD dependent oxidoreductases: Sarcosine dehydrogenase, Dimethylglycine dehydrogenase and Dimethylglycine dehydrogenase. It is situated between the DAO domain (pfam01266) and the GCV_T domain (pfam01571).


Pssm-ID: 465100  Cd Length: 56  Bit Score: 72.10  E-value: 7.56e-16
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2509786629 405 HGYPSENVWELDLKRFGALQSSRTFLRHRVMEVMPLMYDLKVPRWDFQTGRQLRTS 460
Cdd:pfam16350   1 DGEPPIDLWECDIRRFGPHQNNREYLRERVAENYGEVYDIHHPNEEREAGRPLRTS 56
soxA_mon TIGR01377
sarcosine oxidase, monomeric form; Sarcosine oxidase catalyzes the oxidative demethylation of ...
 45-420 1.64e-10

sarcosine oxidase, monomeric form; Sarcosine oxidase catalyzes the oxidative demethylation of sarcosine to glycine. The reaction converts tetrahydrofolate to 5,10-methylene-tetrahydrofolate. The enzyme is known in monomeric and heterotetrameric (alpha,beta,gamma,delta) forms [Energy metabolism, Amino acids and amines]


Pssm-ID: 130444 [Multi-domain]  Cd Length: 380  Bit Score: 63.70  E-value: 1.64e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2509786629  45 VVVCGGGITGTSVAHHQSKMGwKDIVLLEQGRL--AAGSTRfcaGILSTARHLTIEQ---KMADYSNKLYHQLEQETGIQ 119
Cdd:TIGR01377   3 VIVVGAGIMGCFAAYHLAKHG-KKTLLLEQFDLphSRGSSH---GQSRIIRKAYPEDfytPMMLECYQLWAQLEKEAGTK 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2509786629 120 TgYTRTGSIFLAQTQDRliSLKRINAGLNVIGIPSEIISPKKVAELHHLLNVHDLVGAMHVPEDAVVSSADVALALASAA 199
Cdd:TIGR01377  79 L-HRQTGLLLLGPKENQ--FLKTIQATLSRHGLEHELLSSKQLKQRFPNIRVPRNEVGLLDPNGGVLYAEKALRALQELA 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2509786629 200 SQNGVQVYDRTSVLHVMVKKGQVTgVETDKGQIECQYFVNCAGQWAYEL--GLSNEEPVSiPLHACEHFYLLTRPLETPL 277
Cdd:TIGR01377 156 EAHGATVRDGTKVVEIEPTELLVT-VKTTKGSYQANKLVVTAGAWTSKLlsPLGIEIPLQ-PLRINVCYWREKEPGSYGV 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2509786629 278 QSSTPTIV--DADGRIYirnwqgGILSGGFEKNPKPIFTEGKN----------QLEIQNLQEdwdhfeplLSSLLR-RMP 344
Cdd:TIGR01377 234 SQAFPCFLvlGLNPHIY------GLPSFEYPGLMKVYYHHGQQidpderdcpfGADIEDVQI--------LRKFVRdHLP 299

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2509786629 345 EL-ETLEIMKLvnCPETFTPDMRCIMGESPAVQGYFVLAGMNSAGLSFGGGAGKYLAEWMVHGYPSENVWELDLKRF 420
Cdd:TIGR01377 300 GLnGEPKKGEV--CMYTNTPDEHFVIDLHPKYDNVVIGAGFSGHGFKLAPVVGKILAELAMKLKPSYDLAIFSLNRF 374
PRK00711 PRK00711
D-amino acid dehydrogenase;
90-293 2.20e-04

D-amino acid dehydrogenase;


Pssm-ID: 234819 [Multi-domain]  Cd Length: 416  Bit Score: 44.79  E-value: 2.20e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2509786629  90 STARHLTIeqkmADYSNKLYHQLEQETGIQTGYTRTGSIFLAQTQDRLISLKRINAGLNVIGIPSEIISPKKVAELH-HL 168
Cdd:PRK00711  104 NKSRMVRL----AEYSRDCLKALRAETGIQYEGRQGGTLQLFRTQQQLDAAAKDIAVLEEAGVPYELLDRDELAAVEpAL 179

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2509786629 169 LNV-HDLVGAMHVPEDAV-------VSSADvalalasAASQNGVQVYDRTSVLHVMVKKGQVTGVETDKGQIECQYFVNC 240
Cdd:PRK00711  180 AGVrHKLVGGLRLPNDETgdcqlftQRLAA-------MAEQLGVKFRFNTPVDGLLVEGGRITGVQTGGGVITADAYVVA 252

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2509786629 241 AGQWAYEL--GLSNEEPVsIPLHAcehfYLLTRPLETPLQSSTPTIVDADGRIYI 293
Cdd:PRK00711  253 LGSYSTALlkPLGVDIPV-YPLKG----YSLTVPITDEDRAPVSTVLDETYKIAI 302
 
Name Accession Description Interval E-value
GcvT COG0404
Glycine cleavage system protein T (aminomethyltransferase) [Amino acid transport and ...
 454-852 9.41e-86

Glycine cleavage system protein T (aminomethyltransferase) [Amino acid transport and metabolism]; Glycine cleavage system protein T (aminomethyltransferase) is part of the Pathway/BioSystem: Glycine cleavage


Pssm-ID: 440173 [Multi-domain]  Cd Length: 372  Bit Score: 278.50  E-value: 9.41e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2509786629 454 GRQLRTSPLYDRLDAQGARWMEKHGFERPKYFVppdkdllaleqsktfykpdwfDIVESEVKCCKEAVCVIDMSSFTKFE 533
Cdd:COG0404     1 FRPLRRTPLHDRHVALGAKFVDFGGWEMPVQYP---------------------GGVIAEHLAVREAVGLFDVSHMGKIE 59

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2509786629 534 ITstGDQALEVLQYLFSNDLDV-PVGHIVHTGMLNEGGGYENDCSIARLNKRSFFMISPTDQQVHCWAWLKKHMPKDSNL 612
Cdd:COG0404    60 VT--GPDAAAFLDRLVTNDVSKlKPGRARYTLMLNEDGGIIDDLTVYRLGEDRFLLVVNAANAAKDLAWLEEHLPPDFDV 137

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2509786629 613 LLEDVTWKYTALNLIGPRAVDVLSELsyAPMTPDHFPSLFCKEMSVGYAKgIRVMSMTHTGEPGFMLYIPIEYALHVYNE 692
Cdd:COG0404   138 TITDVTDDWALLAVQGPKAREVLAKL--TDADLSALPFMSFREGTVAGVP-VRVSRTGYTGEDGFEIYVPAEDAEALWDA 214

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2509786629 693 VMSVGQKYGIRNAGYYALRSLRIEKFFAFWGQDINNLTTPLECGRESRVKLEKGmDFIGRDALLQQKQNGVYKRLTMFIL 772
Cdd:COG0404   215 LLEAGEEFGVKPCGLGARDTLRLEAGYPLYGHELDETTTPLEAGLGWAVKLDKG-DFIGKEALLRQKEEGPRRKLVGLEL 293

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2509786629 773 DDHDSdldlwPWWGEPIYRNGQYVGKTTSSAYSYSLERHVCLGFVHNFSEDTGEeqvvtadfinrgEYEIDIAGYRFQAK 852
Cdd:COG0404   294 DGRGV-----PRAGAPVLADGEVVGEVTSGTFSPTLGKSIALAYVPAGLARPGT------------ELEVEIRGKRVPAE 356
GCV_T pfam01571
Aminomethyltransferase folate-binding domain; This is a family of glycine cleavage T-proteins, ...
 463-736 4.15e-84

Aminomethyltransferase folate-binding domain; This is a family of glycine cleavage T-proteins, part of the glycine cleavage multienzyme complex (GCV) found in bacteria and the mitochondria of eukaryotes. GCV catalyzes the catabolism of glycine in eukaryotes. The T-protein is an aminomethyl transferase.


Pssm-ID: 460255  Cd Length: 254  Bit Score: 269.84  E-value: 4.15e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2509786629 463 YDRLDAQGARWMEKHGFERPKYFVPPDKDllaleqsktfykpdwfdiveSEVKCCKEAVCVIDMSSFTKFEITstGDQAL 542
Cdd:pfam01571   1 YDRHVALGAKFVEFAGWEMPVQYGSNGIL--------------------AEHRAVREAAGLFDVSHMGKIEVS--GPDAA 58

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2509786629 543 EVLQYLFSNDLD-VPVGHIVHTGMLNEGGGYENDCSIARLNKRSFFMISPTDQQVHCWAWLKKHMPKDsNLLLEDVTWKY 621
Cdd:pfam01571  59 AFLQRLTTNDVSkLKPGRATYTLMLNERGGVIDDLTVYRLGDDHFLLVVNAANREKDLAWLRKHAEKL-DVVVVDVTDDY 137

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2509786629 622 TALNLIGPRAVDVLSELSYAPMTPDhFPSLFCKEMSVGYAKgIRVMSMTHTGEPGFMLYIPIEYALHVYNEVMSVGQKYG 701
Cdd:pfam01571 138 ALLALQGPKAREVLEKLTDGDLLEA-LPFFSFREIEIGGVP-VRVSRTGYTGEDGFEIYVPAEDAVELWEALLEAGAELG 215

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 2509786629 702 IRNAGYYALRSLRIEKFFAFWGQDINNLTTPLECG 736
Cdd:pfam01571 216 LRPAGLGARDSLRLEAGLPLYGHDLDEETTPLEAG 250
DadA COG0665
Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];
41-419 5.61e-70

Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];


Pssm-ID: 440429 [Multi-domain]  Cd Length: 364  Bit Score: 235.95  E-value: 5.61e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2509786629  41 TQAQVVVCGGGITGTSVAHHQSKMGWkDIVLLEQGRLAAGSTRFCAGILST---ARHLTIEQKMADYSNKLYHQLEQETG 117
Cdd:COG0665     1 ATADVVVIGGGIAGLSTAYHLARRGL-DVTVLERGRPGSGASGRNAGQLRPglaALADRALVRLAREALDLWRELAAELG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2509786629 118 IQTGYTRTGSIFLAQTQDRLISLKRINAGLNVIGIPSEIISPKKVAELHHLLNVHDLVGAMHVPEDAVVSSADVALALAS 197
Cdd:COG0665    80 IDCDFRRTGVLYLARTEAELAALRAEAEALRALGLPVELLDAAELREREPGLGSPDYAGGLYDPDDGHVDPAKLVRALAR 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2509786629 198 AASQNGVQVYDRTSVLHVMVKKGQVTGVETDKGQIECQYFVNCAGQWAYELGlsNEEPVSIPLHACEHFYLLTRPLETPL 277
Cdd:COG0665   160 AARAAGVRIREGTPVTGLEREGGRVTGVRTERGTVRADAVVLAAGAWSARLL--PMLGLRLPLRPVRGYVLVTEPLPDLP 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2509786629 278 qssTPTIVDaDGRIYIRNWQGG--ILSGGFEKNPkpiftegknqleiQNLQEDWDHFEPLLSSLLRRMPELETLEIMKLV 355
Cdd:COG0665   238 ---LRPVLD-DTGVYLRPTADGrlLVGGTAEPAG-------------FDRAPTPERLEALLRRLRRLFPALADAEIVRAW 300

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2509786629 356 NCPETFTPDMRCIMGESPAVQGYFVLAGMNSAGLSFGGGAGKYLAEWMVHGYPSENVWELDLKR 419
Cdd:COG0665   301 AGLRPMTPDGLPIIGRLPGAPGLYVATGHGGHGVTLAPAAGRLLADLILGGEPPLDLAPFSPDR 364
DAO pfam01266
FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: ...
 45-402 3.84e-52

FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: Glycerol-3-phosphate dehydrogenase EC:1.1.99.5, Sarcosine oxidase beta subunit EC:1.5.3.1, D-alanine oxidase EC:1.4.99.1, D-aspartate oxidase EC:1.4.3.1.


Pssm-ID: 426168 [Multi-domain]  Cd Length: 339  Bit Score: 185.68  E-value: 3.84e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2509786629  45 VVVCGGGITGTSVAHHQSKMGWkDIVLLEQG-RLAAGSTRFCAGILSTARHLTIEQ---KMADYSNKLYHQLEQETGIQT 120
Cdd:pfam01266   2 VVVIGGGIVGLSTAYELARRGL-SVTLLERGdDPGSGASGRNAGLIHPGLRYLEPSelaRLALEALDLWEELEEELGIDC 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2509786629 121 GYTRTGSIFLAQTQDRlISLKRINAGLNVIGIPSEIISPKKVAELHHLLNvhDLVGAMHVPEDAVVSSADVALALASAAS 200
Cdd:pfam01266  81 GFRRCGVLVLARDEEE-EALEKLLAALRRLGVPAELLDAEELRELEPLLP--GLRGGLFYPDGGHVDPARLLRALARAAE 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2509786629 201 QNGVQVYDRTSVLHVmVKKGQVTGVETDkGQIECqyFVNCAGQWAYELGLSneePVSIPLHACEHFYLLTRPL-ETPLQS 279
Cdd:pfam01266 158 ALGVRIIEGTEVTGI-EEEGGVWGVVTT-GEADA--VVNAAGAWADLLALP---GLRLPVRPVRGQVLVLEPLpEALLIL 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2509786629 280 STPTIVDADGRIYIRN-WQGGILSGGFEknpkpiFTEGKNQLEIqnlqeDWDHFEPLLSSLLRRMPELETLEimklvncp 358
Cdd:pfam01266 231 PVPITVDPGRGVYLRPrADGRLLLGGTD------EEDGFDDPTP-----DPEEIEELLEAARRLFPALADIE-------- 291

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*....
gi 2509786629 359 ETF-----TPDMRCIMGEsPAVQGYFVLAGMNSAGLSFGGGAGKYLAEW 402
Cdd:pfam01266 292 RAWaglrpLPDGLPIIGR-PGSPGLYLATGHGGHGLTLAPGIGKLLAEL 339
gcvT PRK00389
glycine cleavage system aminomethyltransferase GcvT;
457-838 3.12e-38

glycine cleavage system aminomethyltransferase GcvT;


Pssm-ID: 234742 [Multi-domain]  Cd Length: 359  Bit Score: 146.42  E-value: 3.12e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2509786629 457 LRTSPLYDRLDAQGARWMEKHGFERP-KYfvppdkdllaleQSktfykpdwfdIVEsEVKCCKEAVCVIDMSSFTKFEIT 535
Cdd:PRK00389    2 LKRTPLYDLHVALGAKMVDFGGWEMPvQY------------GS----------IIE-EHHAVRTDAGLFDVSHMGEVDVT 58

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2509786629 536 stGDQALEVLQYLFSNDLD-VPVGHIVHTGMLNEGGGYENDCSIARLNKRSFFMI--SPTDQQVhcWAWLKKHMpKDSNL 612
Cdd:PRK00389   59 --GPDALAFLQYLLANDVSkLKPGKAQYTCMLNEDGGVIDDLIVYKLSEDEYLLVvnAANREKD--LAWIKSHA-AGFGV 133

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2509786629 613 LLEDVTWKYTALNLIGPRAVDVLSELSYAPMtpDHFPSLFCKEMSVGYAKGIRVmSMT-HTGEPGFMLYIPIEYALHVYN 691
Cdd:PRK00389  134 EVTDRSDDLAMIAVQGPKAREKLQKLTDADL--SELKPFFGAQGAEVGGGDVLV-ARTgYTGEDGFEIYLPAEDAEALWD 210

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2509786629 692 EVMSVGqkygIRNAGYYALRSLRIEKFFAFWGQDINNLTTPLECGRESRVKLEKGMDFIGRDALLQQKQNGVYKRLTMF- 770
Cdd:PRK00389  211 ALLEAG----VKPCGLGARDTLRLEAGMPLYGQDMDETITPLEAGLGWTVKLEEKRDFIGREALEAQKEAGVERKLVGLe 286

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2509786629 771 -----IlddhdsdldlwPWWGEPIYRNGQYVGKTTSSAYSYSLERHVCLGFVhnfSEDTGEE------------QVVTAD 833
Cdd:PRK00389  287 leergI-----------PRHGYPVLADGEEIGEVTSGTFSPTLGKSIALAYV---PAGVGDEveveirgkqvpaKVVKPP 352


                  ....*
gi 2509786629 834 FINRG 838
Cdd:PRK00389  353 FVRRG 357
LhgO COG0579
L-2-hydroxyglutarate oxidase LhgO [Carbohydrate transport and metabolism];
45-245 1.69e-17

L-2-hydroxyglutarate oxidase LhgO [Carbohydrate transport and metabolism];


Pssm-ID: 440344 [Multi-domain]  Cd Length: 418  Bit Score: 85.97  E-value: 1.69e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2509786629  45 VVVCGGGITGTSVAHHQSK-MGWKdIVLLEQG-RLAAGSTRFCAGILstarH--L-----TIEQKMADYSNKLYHQLEQE 115
Cdd:COG0579     7 VVIIGAGIVGLALARELSRyEDLK-VLVLEKEdDVAQESSGNNSGVI----HagLyytpgSLKARLCVEGNELFYELCRE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2509786629 116 TGIQtgYTRTGSIFLAQTQDRLISLKRINAGLNVIGIPS-EIISPKKVAELHHLLNvHDLVGAMHVPEDAVVSSADVALA 194
Cdd:COG0579    82 LGIP--FKRCGKLVVATGEEEVAFLEKLYERGKANGVPGlEILDREELRELEPLLS-DEGVAALYSPSTGIVDPGALTRA 158

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2509786629 195 LASAASQNGVQVYDRTSVLHVMVKKGQVTgVETDKGQIECQYFVNCAGQWA 245
Cdd:COG0579   159 LAENAEANGVELLLNTEVTGIEREGDGWE-VTTNGGTIRARFVINAAGLYA 208
FAO_M pfam16350
FAD dependent oxidoreductase central domain; This domain occurs in several FAD dependent ...
 405-460 7.56e-16

FAD dependent oxidoreductase central domain; This domain occurs in several FAD dependent oxidoreductases: Sarcosine dehydrogenase, Dimethylglycine dehydrogenase and Dimethylglycine dehydrogenase. It is situated between the DAO domain (pfam01266) and the GCV_T domain (pfam01571).


Pssm-ID: 465100  Cd Length: 56  Bit Score: 72.10  E-value: 7.56e-16
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2509786629 405 HGYPSENVWELDLKRFGALQSSRTFLRHRVMEVMPLMYDLKVPRWDFQTGRQLRTS 460
Cdd:pfam16350   1 DGEPPIDLWECDIRRFGPHQNNREYLRERVAENYGEVYDIHHPNEEREAGRPLRTS 56
dmdA PRK12486
dimethylsulfoniopropionate demethylase;
455-839 3.36e-15

dimethylsulfoniopropionate demethylase;


Pssm-ID: 237113 [Multi-domain]  Cd Length: 368  Bit Score: 78.25  E-value: 3.36e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2509786629 455 RQLRTSPLYDRLDAQGARwmekhGFerpkyfvppdkdllaleqskTFYK----PDWFDIVESEVKCCKEAVCVIDMSSFT 530
Cdd:PRK12486    9 RRLRRTPFSDGVEAAGVK-----AY--------------------TVYNhmllPTVFESVEDDYAHLKEHVQVWDVAVER 63

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2509786629 531 KFEITstGDQALEVLQYLFSNDLD-VPVGHIVHTGMLNEGGGYENDCSIARLNKRSFFmISPTDQQVHCWAwlkKHMPKD 609
Cdd:PRK12486   64 QVEIR--GPDAARLVQMLTPRDLRgMKPGQCYYVPIVDETGGMLNDPVALKLAEDRWW-ISIADSDLLLWV---KGLANG 137

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2509786629 610 SNLLLEDVTWKYTALNLIGPRAVDVLSELSYAPMTPDHF-----PSLFCKEMSV---GYAKgirvmsmthtgEPGFMLYI 681
Cdd:PRK12486  138 RKLDVLVVEPDVSPLAVQGPKADALMARVFGEAIRDLRFfrfgyFDFEGTDLVIarsGYSK-----------QGGFEIYV 206

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2509786629 682 P-IEYALHVYNEVMSVGQKYGIRnAGYYALRSlRIEKFFAFWGQDINNLTTPLECGRESRVKLEKGMDFIGRDALLQQKQ 760
Cdd:PRK12486  207 EgSDLGMPLWDALFEAGKDLNVR-AGCPNLIE-RIEGGLLSYGNDMTRDNTPHECGLGRFCNTQTDIGCIGKDALLRVAK 284

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2509786629 761 NGVYKRLTMFILDDHDSDLDLWPWwgePIYRNGQYVGKTTSSAYSYSLERHVCLGFVHNFSEDTGEE-QVVTADFINRGE 839
Cdd:PRK12486  285 EGPQKQIRGIKIGGERIPPCDRAW---PLLAGDNRVGQVTSAAYSPDFQTNVAIGMVRMTHWDPGTGlEVETPDGMRPAT 361
PLN02319 PLN02319
aminomethyltransferase
 563-817 1.77e-12

aminomethyltransferase


Pssm-ID: 177953 [Multi-domain]  Cd Length: 404  Bit Score: 70.14  E-value: 1.77e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2509786629 563 TGML----NEGGGYENDCSIARLNKRSFFMI-----SPTDQqvhcwAWLKKHMpKDSNLLLEDVTW----KYTALNLIGP 629
Cdd:PLN02319  112 TGTLsvftNEKGGIIDDTVITKVTDDHIYLVvnagcRDKDL-----AHIEEHM-KAFKAKGGDVSWhvhdERSLLALQGP 185

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2509786629 630 RAVDVLSELSYAPMTPDHFpSLFcKEMSVGyAKGIRVMSMTHTGEPGFMLYIPIEYALHVYNEVMSVGQKyGIRNAGYYA 709
Cdd:PLN02319  186 LAAPVLQHLTKEDLSKMYF-GDF-RITDIN-GADCFLTRTGYTGEDGFEISVPSEHAVDLAKALLEKSEG-KVRLTGLGA 261

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2509786629 710 LRSLRIEKFFAFWGQDINNLTTPLECGRE----SRVKlEKGmDFIGRDALLQQKQNGVYKRLTMFILDdhdsdldlwpww 785
Cdd:PLN02319  262 RDSLRLEAGLCLYGNDLEEHITPVEAGLAwtigKRRR-AEG-GFLGADVILKQLKEGVSRRRVGFISS------------ 327

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 2509786629 786 GEP------IY-RNGQYVGKTTSSAYSYSLERHVCLGFV 817
Cdd:PLN02319  328 GAParshseILdESGEKIGEVTSGGFSPCLKKNIAMGYV 366
GCV_T_C pfam08669
Glycine cleavage T-protein C-terminal barrel domain; This is a family of glycine cleavage ...
 786-852 6.20e-11

Glycine cleavage T-protein C-terminal barrel domain; This is a family of glycine cleavage T-proteins, part of the glycine cleavage multienzyme complex (GCV) found in bacteria and the mitochondria of eukaryotes. GCV catalyzes the catabolism of glycine in eukaryotes. The T-protein is an aminomethyl transferase.


Pssm-ID: 462554 [Multi-domain]  Cd Length: 80  Bit Score: 59.03  E-value: 6.20e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2509786629 786 GEPIYRNGQYVGKTTSSAYSYSLERHVCLGFVHnfsedtgeeqvvtADFINRG-EYEIDIAGYRFQAK 852
Cdd:pfam08669  18 GEPVLRDGEVVGYVTSGAYSPTLGKSIALAYVD-------------AELAKPGtEVEVEIRGKRVPAT 72
soxA_mon TIGR01377
sarcosine oxidase, monomeric form; Sarcosine oxidase catalyzes the oxidative demethylation of ...
 45-420 1.64e-10

sarcosine oxidase, monomeric form; Sarcosine oxidase catalyzes the oxidative demethylation of sarcosine to glycine. The reaction converts tetrahydrofolate to 5,10-methylene-tetrahydrofolate. The enzyme is known in monomeric and heterotetrameric (alpha,beta,gamma,delta) forms [Energy metabolism, Amino acids and amines]


Pssm-ID: 130444 [Multi-domain]  Cd Length: 380  Bit Score: 63.70  E-value: 1.64e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2509786629  45 VVVCGGGITGTSVAHHQSKMGwKDIVLLEQGRL--AAGSTRfcaGILSTARHLTIEQ---KMADYSNKLYHQLEQETGIQ 119
Cdd:TIGR01377   3 VIVVGAGIMGCFAAYHLAKHG-KKTLLLEQFDLphSRGSSH---GQSRIIRKAYPEDfytPMMLECYQLWAQLEKEAGTK 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2509786629 120 TgYTRTGSIFLAQTQDRliSLKRINAGLNVIGIPSEIISPKKVAELHHLLNVHDLVGAMHVPEDAVVSSADVALALASAA 199
Cdd:TIGR01377  79 L-HRQTGLLLLGPKENQ--FLKTIQATLSRHGLEHELLSSKQLKQRFPNIRVPRNEVGLLDPNGGVLYAEKALRALQELA 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2509786629 200 SQNGVQVYDRTSVLHVMVKKGQVTgVETDKGQIECQYFVNCAGQWAYEL--GLSNEEPVSiPLHACEHFYLLTRPLETPL 277
Cdd:TIGR01377 156 EAHGATVRDGTKVVEIEPTELLVT-VKTTKGSYQANKLVVTAGAWTSKLlsPLGIEIPLQ-PLRINVCYWREKEPGSYGV 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2509786629 278 QSSTPTIV--DADGRIYirnwqgGILSGGFEKNPKPIFTEGKN----------QLEIQNLQEdwdhfeplLSSLLR-RMP 344
Cdd:TIGR01377 234 SQAFPCFLvlGLNPHIY------GLPSFEYPGLMKVYYHHGQQidpderdcpfGADIEDVQI--------LRKFVRdHLP 299

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2509786629 345 EL-ETLEIMKLvnCPETFTPDMRCIMGESPAVQGYFVLAGMNSAGLSFGGGAGKYLAEWMVHGYPSENVWELDLKRF 420
Cdd:TIGR01377 300 GLnGEPKKGEV--CMYTNTPDEHFVIDLHPKYDNVVIGAGFSGHGFKLAPVVGKILAELAMKLKPSYDLAIFSLNRF 374
gcvT PRK13579
glycine cleavage system aminomethyltransferase GcvT;
534-817 2.98e-09

glycine cleavage system aminomethyltransferase GcvT;


Pssm-ID: 237435 [Multi-domain]  Cd Length: 370  Bit Score: 59.96  E-value: 2.98e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2509786629 534 ITSTGDQALEVLQYLFSND-LDVPVGHIVHTGMLNEGGGYENDCSIARLNKRsFFMISPTDQQVHCWAWLKKHMPKDSNL 612
Cdd:PRK13579   63 IEVSGKDAAAALERLVPVDiLALKEGRQRYTFFTNEQGGILDDLMVTNLGDH-LFLVVNAACKDADIAHLREHLSDECEV 141

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2509786629 613 -LLEDvtwkYTALNLIGPRAVDVLSELSyapmtPDHFPSLFckeMSVGyakGIRVMSMT-------HTGEPGFMLYIPIE 684
Cdd:PRK13579  142 nPLDD----RALLALQGPEAEAVLADLG-----PPVAALRF---MDGF---EPRLHGVDcfvsrsgYTGEDGFEISVPAD 206

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2509786629 685 YA------LHVYNEVMSVGqkYGIRNagyyalrSLRIEKFFAFWGQDINNLTTPLECGRE---SRVKLEKGmDFIGRDAL 755
Cdd:PRK13579  207 AAealaeaLLADPRVEPIG--LGARD-------SLRLEAGLCLYGHDIDTTTTPVEAALEwaiQKARREAG-GFPGAKAI 276

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2509786629 756 LQQKQNGV-YKRLTMFILDDHDSDLdlwpwwGEPIYRN-GQYVGKTTSSAYSYSLERHVCLGFV 817
Cdd:PRK13579  277 LAALAKGAsRRRVGLKPEGRAPVRE------GAPLFDDaGTEIGTVTSGGFGPSVGGPVAMGYV 334
PRK00711 PRK00711
D-amino acid dehydrogenase;
90-293 2.20e-04

D-amino acid dehydrogenase;


Pssm-ID: 234819 [Multi-domain]  Cd Length: 416  Bit Score: 44.79  E-value: 2.20e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2509786629  90 STARHLTIeqkmADYSNKLYHQLEQETGIQTGYTRTGSIFLAQTQDRLISLKRINAGLNVIGIPSEIISPKKVAELH-HL 168
Cdd:PRK00711  104 NKSRMVRL----AEYSRDCLKALRAETGIQYEGRQGGTLQLFRTQQQLDAAAKDIAVLEEAGVPYELLDRDELAAVEpAL 179

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2509786629 169 LNV-HDLVGAMHVPEDAV-------VSSADvalalasAASQNGVQVYDRTSVLHVMVKKGQVTGVETDKGQIECQYFVNC 240
Cdd:PRK00711  180 AGVrHKLVGGLRLPNDETgdcqlftQRLAA-------MAEQLGVKFRFNTPVDGLLVEGGRITGVQTGGGVITADAYVVA 252

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2509786629 241 AGQWAYEL--GLSNEEPVsIPLHAcehfYLLTRPLETPLQSSTPTIVDADGRIYI 293
Cdd:PRK00711  253 LGSYSTALlkPLGVDIPV-YPLKG----YSLTVPITDEDRAPVSTVLDETYKIAI 302
solA PRK11259
N-methyl-L-tryptophan oxidase;
108-422 6.83e-04

N-methyl-L-tryptophan oxidase;


Pssm-ID: 236887 [Multi-domain]  Cd Length: 376  Bit Score: 42.90  E-value: 6.83e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2509786629 108 LYHQLEQETGiQTGYTRTGSIFLAQTQDRLISlkrinaglNVI------GIPSEIISPKKVAELHHLLNVHDlvGAMHV- 180
Cdd:PRK11259   71 LWRELERESG-EPLFVRTGVLNLGPADSDFLA--------NSIrsarqhGLPHEVLDAAEIRRRFPQFRLPD--GYIALf 139

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2509786629 181 --------PEDAVVSSADVALalasaasQNGVQVYDRTSVLHVMVKKGQVTgVETDKGQIECQYFVNCAGQWAYELgLSn 252
Cdd:PRK11259  140 epdggflrPELAIKAHLRLAR-------EAGAELLFNEPVTAIEADGDGVT-VTTADGTYEAKKLVVSAGAWVKDL-LP- 209

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2509786629 253 eePVSIPLHACEH-FYLLTRPLETPLQSSTPtivdadgrIYIRNWQGGILSGGFEKNPKPIFTEGKNQ--LEIQNLQE-- 327
Cdd:PRK11259  210 --PLELPLTPVRQvLAWFQADGRYSEPNRFP--------AFIWEVPDGDQYYGFPAENGPGLKIGKHNggQEITSPDErd 279

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2509786629 328 ---DWDHFEPLLSSLLRR-MPELETLeiMKLVNCPETFTPDMRCIMGESPAVQGYFVLAGMNSAGLSFGGGAGKYLAEWM 403
Cdd:PRK11259  280 rfvTVAEDGAELRPFLRNyLPGVGPC--LRGAACTYTNTPDEHFIIDTLPGHPNVLVASGCSGHGFKFASVLGEILADLA 357

                         330
                  ....*....|....*....
gi 2509786629 404 VHGYPSENVWELDLKRFGA 422
Cdd:PRK11259  358 QDGTSDFDLSPFSLSRFAA 376
PRK11728 PRK11728
L-2-hydroxyglutarate oxidase;
45-242 2.78e-03

L-2-hydroxyglutarate oxidase;


Pssm-ID: 183292 [Multi-domain]  Cd Length: 393  Bit Score: 40.96  E-value: 2.78e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2509786629  45 VVVCGGGITGTSVAHH-QSKMGWKDIVLLE-QGRLAA------------------GS--TRFC-AGilstarhltieqkm 101
Cdd:PRK11728    5 FVIIGGGIVGLSTAMQlQERYPGARIAVLEkESGPARhqtghnsgvihagvyytpGSlkARFCrRG-------------- 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2509786629 102 adysNKLYHQLEQETGIqtGYTRTGSIFLAQTQDRLISLKRI--NAGLNviGIPSEIISPKKVAELHHllNVHDLvGAMH 179
Cdd:PRK11728   71 ----NEATKAFCDQHGI--PYEECGKLLVATSELELERMEALyeRARAN--GIEVERLDAEELREREP--NIRGL-GAIF 139

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2509786629 180 VPEDAVVSSADVALALASAASQNGVQVYDRTSVLHVMVKKGQVTgVETDKGQIECQYFVNCAG 242
Cdd:PRK11728  140 VPSTGIVDYRAVAEAMAELIQARGGEIRLGAEVTALDEHANGVV-VRTTQGEYEARTLINCAG 201
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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