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Conserved domains on  [gi|2501356763|ref|NP_001407903|]
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zinc finger protein 106 isoform 4 [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 10077586)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 741-1018 3.96e-44

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 161.73  E-value: 3.96e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501356763  741 GSFEGHQAAVNAIQIF--GNFLYTCSADTTVRVYNLVSRKCVGVFEGHTSKVNCLLvthTSGKSSVLYTGSSDHTIRCYN 818
Cdd:cd00200      3 RTLKGHTGGVTCVAFSpdGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVA---ASADGTYLASGSSDKTIRLWD 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501356763  819 IKTRECMEQLQL-EDRVLCL--HNRWRTLYAGLANGTVVTFDIKNNKRQEIFECHgPRAVSCLATAQEGarKLLVVGSYD 895
Cdd:cd00200     80 LETGECVRTLTGhTSYVSSVafSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGH-TDWVNSVAFSPDG--TFVASSSQD 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501356763  896 CTISVRDARNGLLLRTLEGHSKTVLCMKVVND--LVFSGSSDQSVHAHNIHTGELVRIYKGHNHAVT--VVNILGKVMVT 971
Cdd:cd00200    157 GTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDgeKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNsvAFSPDGYLLAS 236

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*....
gi 2501356763  972 ACLDKFVRVYELQSHDRLQVYGGHKDMIMCMTIHKS--VIYTGCYDGSI 1018
Cdd:cd00200    237 GSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDgkRLASGSADGTI 285
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 741-1018 3.96e-44

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 161.73  E-value: 3.96e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501356763  741 GSFEGHQAAVNAIQIF--GNFLYTCSADTTVRVYNLVSRKCVGVFEGHTSKVNCLLvthTSGKSSVLYTGSSDHTIRCYN 818
Cdd:cd00200      3 RTLKGHTGGVTCVAFSpdGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVA---ASADGTYLASGSSDKTIRLWD 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501356763  819 IKTRECMEQLQL-EDRVLCL--HNRWRTLYAGLANGTVVTFDIKNNKRQEIFECHgPRAVSCLATAQEGarKLLVVGSYD 895
Cdd:cd00200     80 LETGECVRTLTGhTSYVSSVafSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGH-TDWVNSVAFSPDG--TFVASSSQD 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501356763  896 CTISVRDARNGLLLRTLEGHSKTVLCMKVVND--LVFSGSSDQSVHAHNIHTGELVRIYKGHNHAVT--VVNILGKVMVT 971
Cdd:cd00200    157 GTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDgeKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNsvAFSPDGYLLAS 236

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*....
gi 2501356763  972 ACLDKFVRVYELQSHDRLQVYGGHKDMIMCMTIHKS--VIYTGCYDGSI 1018
Cdd:cd00200    237 GSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDgkRLASGSADGTI 285
WD40 COG2319
WD40 repeat [General function prediction only];
743-1019 3.93e-42

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 159.69  E-value: 3.93e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501356763  743 FEGHQAAVNAIQIF--GNFLYTCSADTTVRVYNLVSRKCVGVFEGHTSKVNCLLVthtSGKSSVLYTGSSDHTIRCYNIK 820
Cdd:COG2319    116 LTGHTGAVRSVAFSpdGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAF---SPDGKLLASGSDDGTVRLWDLA 192

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501356763  821 TRECMEQLQL-EDRVLCLhnRW----RTLYAGLANGTVVTFDIKNNKRQEIFECHGPRaVSCLATAQEGarKLLVVGSYD 895
Cdd:COG2319    193 TGKLLRTLTGhTGAVRSV--AFspdgKLLASGSADGTVRLWDLATGKLLRTLTGHSGS-VRSVAFSPDG--RLLASGSAD 267

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501356763  896 CTISVRDARNGLLLRTLEGHSKTVLCMKVVND--LVFSGSSDQSVHAHNIHTGELVRIYKGHNHAVTVVNI--LGKVMVT 971
Cdd:COG2319    268 GTVRLWDLATGELLRTLTGHSGGVNSVAFSPDgkLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFspDGKTLAS 347

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|
gi 2501356763  972 ACLDKFVRVYELQSHDRLQVYGGHKDMIMCMTIHK--SVIYTGCYDGSIQ 1019
Cdd:COG2319    348 GSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPdgRTLASGSADGTVR 397
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 776-818 7.69e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.84  E-value: 7.69e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 2501356763   776 SRKCVGVFEGHTSKVNCLLVthtSGKSSVLYTGSSDHTIRCYN 818
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAF---SPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
777-818 6.57e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.18  E-value: 6.57e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2501356763  777 RKCVGVFEGHTSKVNCLLVthtSGKSSVLYTGSSDHTIRCYN 818
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAF---SPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 741-1018 3.96e-44

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 161.73  E-value: 3.96e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501356763  741 GSFEGHQAAVNAIQIF--GNFLYTCSADTTVRVYNLVSRKCVGVFEGHTSKVNCLLvthTSGKSSVLYTGSSDHTIRCYN 818
Cdd:cd00200      3 RTLKGHTGGVTCVAFSpdGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVA---ASADGTYLASGSSDKTIRLWD 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501356763  819 IKTRECMEQLQL-EDRVLCL--HNRWRTLYAGLANGTVVTFDIKNNKRQEIFECHgPRAVSCLATAQEGarKLLVVGSYD 895
Cdd:cd00200     80 LETGECVRTLTGhTSYVSSVafSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGH-TDWVNSVAFSPDG--TFVASSSQD 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501356763  896 CTISVRDARNGLLLRTLEGHSKTVLCMKVVND--LVFSGSSDQSVHAHNIHTGELVRIYKGHNHAVT--VVNILGKVMVT 971
Cdd:cd00200    157 GTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDgeKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNsvAFSPDGYLLAS 236

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*....
gi 2501356763  972 ACLDKFVRVYELQSHDRLQVYGGHKDMIMCMTIHKS--VIYTGCYDGSI 1018
Cdd:cd00200    237 GSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDgkRLASGSADGTI 285
WD40 COG2319
WD40 repeat [General function prediction only];
743-1019 3.93e-42

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 159.69  E-value: 3.93e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501356763  743 FEGHQAAVNAIQIF--GNFLYTCSADTTVRVYNLVSRKCVGVFEGHTSKVNCLLVthtSGKSSVLYTGSSDHTIRCYNIK 820
Cdd:COG2319    116 LTGHTGAVRSVAFSpdGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAF---SPDGKLLASGSDDGTVRLWDLA 192

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501356763  821 TRECMEQLQL-EDRVLCLhnRW----RTLYAGLANGTVVTFDIKNNKRQEIFECHGPRaVSCLATAQEGarKLLVVGSYD 895
Cdd:COG2319    193 TGKLLRTLTGhTGAVRSV--AFspdgKLLASGSADGTVRLWDLATGKLLRTLTGHSGS-VRSVAFSPDG--RLLASGSAD 267

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501356763  896 CTISVRDARNGLLLRTLEGHSKTVLCMKVVND--LVFSGSSDQSVHAHNIHTGELVRIYKGHNHAVTVVNI--LGKVMVT 971
Cdd:COG2319    268 GTVRLWDLATGELLRTLTGHSGGVNSVAFSPDgkLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFspDGKTLAS 347

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|
gi 2501356763  972 ACLDKFVRVYELQSHDRLQVYGGHKDMIMCMTIHK--SVIYTGCYDGSIQ 1019
Cdd:COG2319    348 GSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPdgRTLASGSADGTVR 397
WD40 COG2319
WD40 repeat [General function prediction only];
742-1019 8.82e-39

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 149.68  E-value: 8.82e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501356763  742 SFEGHQAAVNAIQIF--GNFLYTCSADTTVRVYNLVSRKCVGVFEGHTSKVNCLLVTHtSGKssVLYTGSSDHTIRCYNI 819
Cdd:COG2319     73 TLLGHTAAVLSVAFSpdGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSP-DGK--TLASGSADGTVRLWDL 149

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501356763  820 KTRECMEQLQL-EDRVLCLhnRW----RTLYAGLANGTVVTFDIKNNKRQEIFECHgPRAVSCLATAQEGarKLLVVGSY 894
Cdd:COG2319    150 ATGKLLRTLTGhSGAVTSV--AFspdgKLLASGSDDGTVRLWDLATGKLLRTLTGH-TGAVRSVAFSPDG--KLLASGSA 224

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501356763  895 DCTISVRDARNGLLLRTLEGHSKTVLCMKVVND--LVFSGSSDQSVHAHNIHTGELVRIYKGHNHAVTVVNIL--GKVMV 970
Cdd:COG2319    225 DGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDgrLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSpdGKLLA 304

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2501356763  971 TACLDKFVRVYELQSHDRLQVYGGHKDMIMCMTIH--KSVIYTGCYDGSIQ 1019
Cdd:COG2319    305 SGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSpdGKTLASGSDDGTVR 355
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 742-982 4.54e-38

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 144.40  E-value: 4.54e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501356763  742 SFEGHQAAVNAIQI--FGNFLYTCSADTTVRVYNLVSRKCVGVFEGHTSKVNCLLVTHtsgKSSVLYTGSSDHTIRCYNI 819
Cdd:cd00200     46 TLKGHTGPVRDVAAsaDGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSP---DGRILSSSSRDKTIKVWDV 122

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501356763  820 KTRECMEQLQL-EDRVLCLhnRW----RTLYAGLANGTVVTFDIKNNKRQEIFECHgPRAVSCLATAQEGARklLVVGSY 894
Cdd:cd00200    123 ETGKCLTTLRGhTDWVNSV--AFspdgTFVASSSQDGTIKLWDLRTGKCVATLTGH-TGEVNSVAFSPDGEK--LLSSSS 197

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501356763  895 DCTISVRDARNGLLLRTLEGHSKTVLCMKV--VNDLVFSGSSDQSVHAHNIHTGELVRIYKGHNHAVTVVNI--LGKVMV 970
Cdd:cd00200    198 DGTIKLWDLSTGKCLGTLRGHENGVNSVAFspDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWspDGKRLA 277

                          250
                   ....*....|..
gi 2501356763  971 TACLDKFVRVYE 982
Cdd:cd00200    278 SGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
742-985 2.27e-37

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 145.82  E-value: 2.27e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501356763  742 SFEGHQAAVNAIQIF--GNFLYTCSADTTVRVYNLVSRKCVGVFEGHTSKVNCLLVthtSGKSSVLYTGSSDHTIRCYNI 819
Cdd:COG2319    157 TLTGHSGAVTSVAFSpdGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAF---SPDGKLLASGSADGTVRLWDL 233

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501356763  820 KTRECMEQLQL-EDRVLCLhnRW----RTLYAGLANGTVVTFDIKNNKRQEIFEcHGPRAVSCLATAQEGarKLLVVGSY 894
Cdd:COG2319    234 ATGKLLRTLTGhSGSVRSV--AFspdgRLLASGSADGTVRLWDLATGELLRTLT-GHSGGVNSVAFSPDG--KLLASGSD 308

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501356763  895 DCTISVRDARNGLLLRTLEGHSKTVLCMKVVND--LVFSGSSDQSVHAHNIHTGELVRIYKGHNHAVTVVNIL--GKVMV 970
Cdd:COG2319    309 DGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDgkTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSpdGRTLA 388

                          250
                   ....*....|....*
gi 2501356763  971 TACLDKFVRVYELQS 985
Cdd:COG2319    389 SGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 779-1018 7.55e-34

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 132.07  E-value: 7.55e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501356763  779 CVGVFEGHTSKVNCLlvtHTSGKSSVLYTGSSDHTIRCYNIKTRECMEQLQLE----DRVLCLHNRwRTLYAGLANGTVV 854
Cdd:cd00200      1 LRRTLKGHTGGVTCV---AFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHtgpvRDVAASADG-TYLASGSSDKTIR 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501356763  855 TFDIKNNKRQEIFECHgPRAVSCLATAQEGarKLLVVGSYDCTISVRDARNGLLLRTLEGHSKTVLCMKV--VNDLVFSG 932
Cdd:cd00200     77 LWDLETGECVRTLTGH-TSYVSSVAFSPDG--RILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFspDGTFVASS 153

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501356763  933 SSDQSVHAHNIHTGELVRIYKGHNHAVTVVNIL--GKVMVTACLDKFVRVYELQSHDRLQVYGGHKDMIMCMTIHKS--V 1008
Cdd:cd00200    154 SQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSpdGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDgyL 233

                          250
                   ....*....|
gi 2501356763 1009 IYTGCYDGSI 1018
Cdd:cd00200    234 LASGSEDGTI 243
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 713-938 2.26e-27

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 113.20  E-value: 2.26e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501356763  713 TQTVISIKASKHSSEISSEPGD--------DEEPTEGSFEGHQAAVNAIQI--FGNFLYTCSADTTVRVYNLVSRKCVGV 782
Cdd:cd00200     93 TSYVSSVAFSPDGRILSSSSRDktikvwdvETGKCLTTLRGHTDWVNSVAFspDGTFVASSSQDGTIKLWDLRTGKCVAT 172

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501356763  783 FEGHTSKVNCLLVthtSGKSSVLYTGSSDHTIRCYNIKTRECMEQLQledrvlcLHNRWrtlyaglangtvvtfdiknnk 862
Cdd:cd00200    173 LTGHTGEVNSVAF---SPDGEKLLSSSSDGTIKLWDLSTGKCLGTLR-------GHENG--------------------- 221

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2501356763  863 rqeifechgpraVSCLATAQEgaRKLLVVGSYDCTISVRDARNGLLLRTLEGHSKTVLCMKVVND--LVFSGSSDQSV 938
Cdd:cd00200    222 ------------VNSVAFSPD--GYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDgkRLASGSADGTI 285
WD40 COG2319
WD40 repeat [General function prediction only];
870-1019 6.45e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 62.62  E-value: 6.45e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501356763  870 HGPRAVSCLATAQEGARklLVVGSYDCTISVRDARNGLLLRTLEGHSKTVLCMKVVND--LVFSGSSDQSVHAHNIHTGE 947
Cdd:COG2319     34 GLAAAVASLAASPDGAR--LAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDgrLLASASADGTVRLWDLATGL 111

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2501356763  948 LVRIYKGHNHAVTVVNIL--GKVMVTACLDKFVRVYELQSHDRLQVYGGHKDMIMCMTIHK--SVIYTGCYDGSIQ 1019
Cdd:COG2319    112 LLRTLTGHTGAVRSVAFSpdGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPdgKLLASGSDDGTVR 187
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 776-818 7.69e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.84  E-value: 7.69e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 2501356763   776 SRKCVGVFEGHTSKVNCLLVthtSGKSSVLYTGSSDHTIRCYN 818
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAF---SPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
777-818 6.57e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.18  E-value: 6.57e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2501356763  777 RKCVGVFEGHTSKVNCLLVthtSGKSSVLYTGSSDHTIRCYN 818
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAF---SPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 742-773 4.77e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.83  E-value: 4.77e-04
                            10        20        30
                    ....*....|....*....|....*....|....
gi 2501356763   742 SFEGHQAAVNAIQIF--GNFLYTCSADTTVRVYN 773
Cdd:smart00320    7 TLKGHTGPVTSVAFSpdGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
741-773 8.22e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.10  E-value: 8.22e-04
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2501356763  741 GSFEGHQAAVNAIQI--FGNFLYTCSADTTVRVYN 773
Cdd:pfam00400    5 KTLEGHTGSVTSLAFspDGKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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