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Conserved domains on  [gi|2465536027|ref|NP_001405800|]
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E3 ubiquitin-protein ligase E3D isoform 2 [Mus musculus]

Protein Classification

HECT-type E3 ubiquitin transferase( domain architecture ID 10561263)

HECT-type E3 ubiquitin transferase such as mammalian E3 ubiquitin-protein ligase E3D that accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HECT_2 pfam09814
HECT-like Ubiquitin-conjugating enzyme (E2)-binding; HECT_2 is a family of UbcH10-binding ...
 13-316 4.58e-85

HECT-like Ubiquitin-conjugating enzyme (E2)-binding; HECT_2 is a family of UbcH10-binding proteins.


:

Pssm-ID: 462911  Cd Length: 362  Bit Score: 260.47  E-value: 4.58e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2465536027  13 EVRRRLQSALLILGGPDEggmHLDISIT---PTSLLVRTPDGCTEIRLPAGVRLVPSSCGGLQYISGDGLHLRLRVQAES 89
Cdd:pfam09814   1 ELLPNIRSISVVVSLPSP---LKSTRVSlsdDGLLLVRHNGSSETIRLPAEVSVGSSLGRSQLPLPGDELSFRLPLADSS 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2465536027  90 SPQPISVFNQSLQAQEC-------------CTFYCQSCGEVTIKDRKLLRVLPLPSENWSALVGEWCCHPDPF------- 149
Cdd:pfam09814  78 SKFGSFDLESSLSAQKElevpwsakdlspgFSFCCRSCGNVLVESRNIKRWKDLPSENWAEMMDFWHCHKPDDhdhlatk 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2465536027 150 ---ANRPLHPRENDCFIGDSFFLVNlKSDLE------QEPKANTKVICKRCKVTLGETMSSETTKFYMTEVIIRPSEGSF 220
Cdd:pfam09814 158 gygANSKLVPQEGDGLVGLTFFLLN-ESDCQglklssKPPKDNLSVSCKRCGALLGEVDSLDGLKLYKWALSLQPSEGSD 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2465536027 221 PNiPRSQFLQSIIAQCLVELSSARSTFRFTIQGQDG-KVYILLWVLNSDSLVIeplrssscsrkfplleSSLEAGSGSAW 299
Cdd:pfam09814 237 SI-PRSFPPESIVAALLLELISRSSTRKFLIQPEDGeTHYLLLWVFNPDLLVS----------------SSSSSNSLIAK 299

                         330
                  ....*....|....*..
gi 2465536027 300 NAIKVLYQPCIKSRNKE 316
Cdd:pfam09814 300 RAMKVLYKDCIDSEEAN 316
 
Name Accession Description Interval E-value
HECT_2 pfam09814
HECT-like Ubiquitin-conjugating enzyme (E2)-binding; HECT_2 is a family of UbcH10-binding ...
 13-316 4.58e-85

HECT-like Ubiquitin-conjugating enzyme (E2)-binding; HECT_2 is a family of UbcH10-binding proteins.


Pssm-ID: 462911  Cd Length: 362  Bit Score: 260.47  E-value: 4.58e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2465536027  13 EVRRRLQSALLILGGPDEggmHLDISIT---PTSLLVRTPDGCTEIRLPAGVRLVPSSCGGLQYISGDGLHLRLRVQAES 89
Cdd:pfam09814   1 ELLPNIRSISVVVSLPSP---LKSTRVSlsdDGLLLVRHNGSSETIRLPAEVSVGSSLGRSQLPLPGDELSFRLPLADSS 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2465536027  90 SPQPISVFNQSLQAQEC-------------CTFYCQSCGEVTIKDRKLLRVLPLPSENWSALVGEWCCHPDPF------- 149
Cdd:pfam09814  78 SKFGSFDLESSLSAQKElevpwsakdlspgFSFCCRSCGNVLVESRNIKRWKDLPSENWAEMMDFWHCHKPDDhdhlatk 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2465536027 150 ---ANRPLHPRENDCFIGDSFFLVNlKSDLE------QEPKANTKVICKRCKVTLGETMSSETTKFYMTEVIIRPSEGSF 220
Cdd:pfam09814 158 gygANSKLVPQEGDGLVGLTFFLLN-ESDCQglklssKPPKDNLSVSCKRCGALLGEVDSLDGLKLYKWALSLQPSEGSD 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2465536027 221 PNiPRSQFLQSIIAQCLVELSSARSTFRFTIQGQDG-KVYILLWVLNSDSLVIeplrssscsrkfplleSSLEAGSGSAW 299
Cdd:pfam09814 237 SI-PRSFPPESIVAALLLELISRSSTRKFLIQPEDGeTHYLLLWVFNPDLLVS----------------SSSSSNSLIAK 299

                         330
                  ....*....|....*..
gi 2465536027 300 NAIKVLYQPCIKSRNKE 316
Cdd:pfam09814 300 RAMKVLYKDCIDSEEAN 316
COG5629 COG5629
Predicted metal-binding protein [Function unknown];
108-317 1.02e-08

Predicted metal-binding protein [Function unknown];


Pssm-ID: 227916  Cd Length: 321  Bit Score: 55.81  E-value: 1.02e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2465536027 108 TFYCQSCGEVTIKDRKLLRvlpLPSENWSALVGEWCCHPDPFANRP-------LHPRENDCFIGDSFFLVNLkSDLE--Q 178
Cdd:COG5629    87 GFRCKQGNEILHSIRSMND---LPSEGWEELIDCWSCHNDYCEFKSmlggpltPRPREGGLLLGDSYLLIND-ADLEgkV 162

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2465536027 179 EPKANTKVICKRCKVTLGETMSSETTK-FYMTEVIIRPSEGSFPNiprsqflQSIIAQCLVELSSARSTFRFTIqgQDGK 257
Cdd:COG5629   163 AYGPNFKLHCSFCNARLGLPNDSSIRKlFRYNKEVIPNGCTKIHP-------HEDLAYSYLNAYFRDKNVLLLE--ANQA 233

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2465536027 258 VYILLWVLNSDSLV-IEPlrSSSCSRKFPLLESsleagsgsawnaIKVLY-QPCIKSRNKEW 317
Cdd:COG5629   234 RSYEIWHFYRAILItVEP--NRSLSRAEAMKVT------------IKNTDvPPKITKSTESS 281
 
Name Accession Description Interval E-value
HECT_2 pfam09814
HECT-like Ubiquitin-conjugating enzyme (E2)-binding; HECT_2 is a family of UbcH10-binding ...
 13-316 4.58e-85

HECT-like Ubiquitin-conjugating enzyme (E2)-binding; HECT_2 is a family of UbcH10-binding proteins.


Pssm-ID: 462911  Cd Length: 362  Bit Score: 260.47  E-value: 4.58e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2465536027  13 EVRRRLQSALLILGGPDEggmHLDISIT---PTSLLVRTPDGCTEIRLPAGVRLVPSSCGGLQYISGDGLHLRLRVQAES 89
Cdd:pfam09814   1 ELLPNIRSISVVVSLPSP---LKSTRVSlsdDGLLLVRHNGSSETIRLPAEVSVGSSLGRSQLPLPGDELSFRLPLADSS 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2465536027  90 SPQPISVFNQSLQAQEC-------------CTFYCQSCGEVTIKDRKLLRVLPLPSENWSALVGEWCCHPDPF------- 149
Cdd:pfam09814  78 SKFGSFDLESSLSAQKElevpwsakdlspgFSFCCRSCGNVLVESRNIKRWKDLPSENWAEMMDFWHCHKPDDhdhlatk 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2465536027 150 ---ANRPLHPRENDCFIGDSFFLVNlKSDLE------QEPKANTKVICKRCKVTLGETMSSETTKFYMTEVIIRPSEGSF 220
Cdd:pfam09814 158 gygANSKLVPQEGDGLVGLTFFLLN-ESDCQglklssKPPKDNLSVSCKRCGALLGEVDSLDGLKLYKWALSLQPSEGSD 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2465536027 221 PNiPRSQFLQSIIAQCLVELSSARSTFRFTIQGQDG-KVYILLWVLNSDSLVIeplrssscsrkfplleSSLEAGSGSAW 299
Cdd:pfam09814 237 SI-PRSFPPESIVAALLLELISRSSTRKFLIQPEDGeTHYLLLWVFNPDLLVS----------------SSSSSNSLIAK 299

                         330
                  ....*....|....*..
gi 2465536027 300 NAIKVLYQPCIKSRNKE 316
Cdd:pfam09814 300 RAMKVLYKDCIDSEEAN 316
COG5629 COG5629
Predicted metal-binding protein [Function unknown];
108-317 1.02e-08

Predicted metal-binding protein [Function unknown];


Pssm-ID: 227916  Cd Length: 321  Bit Score: 55.81  E-value: 1.02e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2465536027 108 TFYCQSCGEVTIKDRKLLRvlpLPSENWSALVGEWCCHPDPFANRP-------LHPRENDCFIGDSFFLVNLkSDLE--Q 178
Cdd:COG5629    87 GFRCKQGNEILHSIRSMND---LPSEGWEELIDCWSCHNDYCEFKSmlggpltPRPREGGLLLGDSYLLIND-ADLEgkV 162

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2465536027 179 EPKANTKVICKRCKVTLGETMSSETTK-FYMTEVIIRPSEGSFPNiprsqflQSIIAQCLVELSSARSTFRFTIqgQDGK 257
Cdd:COG5629   163 AYGPNFKLHCSFCNARLGLPNDSSIRKlFRYNKEVIPNGCTKIHP-------HEDLAYSYLNAYFRDKNVLLLE--ANQA 233

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2465536027 258 VYILLWVLNSDSLV-IEPlrSSSCSRKFPLLESsleagsgsawnaIKVLY-QPCIKSRNKEW 317
Cdd:COG5629   234 RSYEIWHFYRAILItVEP--NRSLSRAEAMKVT------------IKNTDvPPKITKSTESS 281
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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