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Conserved domains on  [gi|2431125025|ref|NP_001403212|]
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rho GTPase-activating protein 39 isoform 4 [Mus musculus]

Protein Classification

Rho GTPase-activating protein( domain architecture ID 11108663)

Rho GTPase-activating protein for Rho/Rac/Cdc42-like small GTPases that act as molecular switches, active in their GTP-bound form but inactive when bound to GDP

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RhoGAP_KIAA1688 cd04389
RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 883-1068 2.31e-119

RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in KIAA1688-like proteins; KIAA1688 is a protein of unknown function that contains a RhoGAP domain and a myosin tail homology 4 (MyTH4) domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


:

Pssm-ID: 239854  Cd Length: 187  Bit Score: 364.40  E-value: 2.31e-119
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431125025  883 FGSALQEVMSMQKERYPDRQLPWVQTRLSEEVLALNGDQTEGIFRVPGDIDEVNALKLQVDQWKVP-TGLEDPHVPASLL 961
Cdd:cd04389      1 FGSSLEEIMDRQKEKYPELKLPWILTFLSEKVLALGGFQTEGIFRVPGDIDEVNELKLRVDQWDYPlSGLEDPHVPASLL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431125025  962 KLWYRELEEPLIPHEFYEQCIAHYESPEAAVAVVHALPRINRMVLCYLIRFLQVFVQPANVAITKMDVSNLAMVMAPNCL 1041
Cdd:cd04389     81 KLWLRELEEPLIPDALYQQCISASEDPDKAVEIVQKLPIINRLVLCYLINFLQVFAQPENVAHTKMDVSNLAMVFAPNIL 160

                          170       180
                   ....*....|....*....|....*..
gi 2431125025 1042 RCQSDDPRVIFENTRKEMSFLRVLIQH 1068
Cdd:cd04389    161 RCTSDDPRVIFENTRKEMSFLRTLIEH 187
MyTH4 pfam00784
MyTH4 domain; Domain in myosin and kinesin tails, present twice in myosin-VIIa, and also ...
 762-872 1.22e-36

MyTH4 domain; Domain in myosin and kinesin tails, present twice in myosin-VIIa, and also present in 3 other myosins.


:

Pssm-ID: 459939  Cd Length: 105  Bit Score: 133.47  E-value: 1.22e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431125025  762 ALEIATKGWSAQGLRDELYIQLCRQTTENFRLESLARGWELMAICLAFFPPTPKFHSYLEGYIYRHMDPvndtKGVAIST 841
Cdd:pfam00784    1 AQNILQKGLKRPELRDEIYCQLIKQTTNNPKPESLLRGWQLLALCLGTFPPSKKLLKYLLKFLKRHADD----PSREVGK 76

                           90       100       110
                   ....*....|....*....|....*....|.
gi 2431125025  842 YAKYCYHKLQKAALTGAKKglKKPNVEEIRH 872
Cdd:pfam00784   77 YAQFCLKRLKRTLKNGGRK--YPPSREEIEA 105
 
Name Accession Description Interval E-value
RhoGAP_KIAA1688 cd04389
RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 883-1068 2.31e-119

RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in KIAA1688-like proteins; KIAA1688 is a protein of unknown function that contains a RhoGAP domain and a myosin tail homology 4 (MyTH4) domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239854  Cd Length: 187  Bit Score: 364.40  E-value: 2.31e-119
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431125025  883 FGSALQEVMSMQKERYPDRQLPWVQTRLSEEVLALNGDQTEGIFRVPGDIDEVNALKLQVDQWKVP-TGLEDPHVPASLL 961
Cdd:cd04389      1 FGSSLEEIMDRQKEKYPELKLPWILTFLSEKVLALGGFQTEGIFRVPGDIDEVNELKLRVDQWDYPlSGLEDPHVPASLL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431125025  962 KLWYRELEEPLIPHEFYEQCIAHYESPEAAVAVVHALPRINRMVLCYLIRFLQVFVQPANVAITKMDVSNLAMVMAPNCL 1041
Cdd:cd04389     81 KLWLRELEEPLIPDALYQQCISASEDPDKAVEIVQKLPIINRLVLCYLINFLQVFAQPENVAHTKMDVSNLAMVFAPNIL 160

                          170       180
                   ....*....|....*....|....*..
gi 2431125025 1042 RCQSDDPRVIFENTRKEMSFLRVLIQH 1068
Cdd:cd04389    161 RCTSDDPRVIFENTRKEMSFLRTLIEH 187
RhoGAP pfam00620
RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.
 904-1045 1.64e-43

RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.


Pssm-ID: 459875  Cd Length: 148  Bit Score: 155.01  E-value: 1.64e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431125025  904 PWVQTRLSEEVLAlNGDQTEGIFRVPGDIDEVNALKLQVDQWKVP---TGLEDPHVPASLLKLWYRELEEPLIPHEFYEQ 980
Cdd:pfam00620    1 PLIVRKCVEYLEK-RGLDTEGIFRVSGSASRIKELREAFDRGPDVdldLEEEDVHVVASLLKLFLRELPEPLLTFELYEE 79

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2431125025  981 CIA------HYESPEAAVAVVHALPRINRMVLCYLIRFLQVFVQpaNVAITKMDVSNLAMVMAPNCLRCQS 1045
Cdd:pfam00620   80 FIEaaklpdEEERLEALRELLRKLPPANRDTLRYLLAHLNRVAQ--NSDVNKMNAHNLAIVFGPTLLRPPD 148
MyTH4 pfam00784
MyTH4 domain; Domain in myosin and kinesin tails, present twice in myosin-VIIa, and also ...
 762-872 1.22e-36

MyTH4 domain; Domain in myosin and kinesin tails, present twice in myosin-VIIa, and also present in 3 other myosins.


Pssm-ID: 459939  Cd Length: 105  Bit Score: 133.47  E-value: 1.22e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431125025  762 ALEIATKGWSAQGLRDELYIQLCRQTTENFRLESLARGWELMAICLAFFPPTPKFHSYLEGYIYRHMDPvndtKGVAIST 841
Cdd:pfam00784    1 AQNILQKGLKRPELRDEIYCQLIKQTTNNPKPESLLRGWQLLALCLGTFPPSKKLLKYLLKFLKRHADD----PSREVGK 76

                           90       100       110
                   ....*....|....*....|....*....|.
gi 2431125025  842 YAKYCYHKLQKAALTGAKKglKKPNVEEIRH 872
Cdd:pfam00784   77 YAQFCLKRLKRTLKNGGRK--YPPSREEIEA 105
RhoGAP smart00324
GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac ...
 918-1068 1.41e-31

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.


Pssm-ID: 214618  Cd Length: 174  Bit Score: 121.60  E-value: 1.41e-31
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431125025   918 NGDQTEGIFRVPGDIDEVNALKLQVDQWKVPTGLE---DPHVPASLLKLWYRELEEPLIPHEFYEQCIA------HYESP 988
Cdd:smart00324   17 RGLDTEGIYRVSGSKSRVKELRDAFDSGPDPDLDLseyDVHDVAGLLKLFLRELPEPLITYELYEEFIEaakledETERL 96

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431125025   989 EAAVAVVHALPRINRMVLCYLIRFLQVFVQpaNVAITKMDVSNLAMVMAPNCLRCQSDDPRVIFENTRKeMSFLRVLIQH 1068
Cdd:smart00324   97 RALRELLSLLPPANRATLRYLLAHLNRVAE--HSEENKMTARNLAIVFGPTLLRPPDGEVASLKDIRHQ-NTVIEFLIEN 173
MyTH4 smart00139
Domain in Myosin and Kinesin Tails; Domain present twice in myosin-VIIa, and also present in 3 ...
 717-871 1.54e-31

Domain in Myosin and Kinesin Tails; Domain present twice in myosin-VIIa, and also present in 3 other myosins.


Pssm-ID: 214535  Cd Length: 152  Bit Score: 120.93  E-value: 1.54e-31
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431125025   717 WSSESIKKPMIVTSDRHVKKEACEIFKLIQMYMGDRRAKADPLHVAL--EIATKGWSAQGLRDELYIQLCRQTTENFRLE 794
Cdd:smart00139    1 YTKDPIKTSLLKLESDELQKEAVKIFKAILKFMGDIPLPRPDSHLDLvqFILQKGLDHPELRDEIYCQLIKQLTDNPSRQ 80

                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2431125025   795 SLARGWELMAICLAFFPPTPKFHSYLEGYIYRHMDPVNDTKgvaistYAKYCYHKLQKAALTGAKKglKKPNVEEIR 871
Cdd:smart00139   81 SEERGWQLLYLCTSLFPPSERLLPYLLQFLSRRADPGSEQG------LAKYCLYRLERTLKNGARK--QPPSRLELE 149
 
Name Accession Description Interval E-value
RhoGAP_KIAA1688 cd04389
RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 883-1068 2.31e-119

RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in KIAA1688-like proteins; KIAA1688 is a protein of unknown function that contains a RhoGAP domain and a myosin tail homology 4 (MyTH4) domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239854  Cd Length: 187  Bit Score: 364.40  E-value: 2.31e-119
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431125025  883 FGSALQEVMSMQKERYPDRQLPWVQTRLSEEVLALNGDQTEGIFRVPGDIDEVNALKLQVDQWKVP-TGLEDPHVPASLL 961
Cdd:cd04389      1 FGSSLEEIMDRQKEKYPELKLPWILTFLSEKVLALGGFQTEGIFRVPGDIDEVNELKLRVDQWDYPlSGLEDPHVPASLL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431125025  962 KLWYRELEEPLIPHEFYEQCIAHYESPEAAVAVVHALPRINRMVLCYLIRFLQVFVQPANVAITKMDVSNLAMVMAPNCL 1041
Cdd:cd04389     81 KLWLRELEEPLIPDALYQQCISASEDPDKAVEIVQKLPIINRLVLCYLINFLQVFAQPENVAHTKMDVSNLAMVFAPNIL 160

                          170       180
                   ....*....|....*....|....*..
gi 2431125025 1042 RCQSDDPRVIFENTRKEMSFLRVLIQH 1068
Cdd:cd04389    161 RCTSDDPRVIFENTRKEMSFLRTLIEH 187
RhoGAP pfam00620
RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.
 904-1045 1.64e-43

RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.


Pssm-ID: 459875  Cd Length: 148  Bit Score: 155.01  E-value: 1.64e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431125025  904 PWVQTRLSEEVLAlNGDQTEGIFRVPGDIDEVNALKLQVDQWKVP---TGLEDPHVPASLLKLWYRELEEPLIPHEFYEQ 980
Cdd:pfam00620    1 PLIVRKCVEYLEK-RGLDTEGIFRVSGSASRIKELREAFDRGPDVdldLEEEDVHVVASLLKLFLRELPEPLLTFELYEE 79

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2431125025  981 CIA------HYESPEAAVAVVHALPRINRMVLCYLIRFLQVFVQpaNVAITKMDVSNLAMVMAPNCLRCQS 1045
Cdd:pfam00620   80 FIEaaklpdEEERLEALRELLRKLPPANRDTLRYLLAHLNRVAQ--NSDVNKMNAHNLAIVFGPTLLRPPD 148
RhoGAP cd00159
RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like ...
 904-1068 5.35e-41

RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to GDP. The Rho family of small G proteins, which includes Cdc42Hs, activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. G proteins generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude. The RhoGAPs are one of the major classes of regulators of Rho G proteins.


Pssm-ID: 238090 [Multi-domain]  Cd Length: 169  Bit Score: 148.60  E-value: 5.35e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431125025  904 PWVQTRLSEEVLAlNGDQTEGIFRVPGDIDEVNALKLQVDQWKVPTGLE--DPHVPASLLKLWYRELEEPLIPHEFYEQC 981
Cdd:cd00159      1 PLIIEKCIEYLEK-NGLNTEGIFRVSGSASKIEELKKKFDRGEDIDDLEdyDVHDVASLLKLYLRELPEPLIPFELYDEF 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431125025  982 IAHY------ESPEAAVAVVHALPRINRMVLCYLIRFLQVFVQpaNVAITKMDVSNLAMVMAPNCLRCQSDDpRVIFENT 1055
Cdd:cd00159     80 IELAkiedeeERIEALKELLKSLPPENRDLLKYLLKLLHKISQ--NSEVNKMTASNLAIVFAPTLLRPPDSD-DELLEDI 156

                          170
                   ....*....|...
gi 2431125025 1056 RKEMSFLRVLIQH 1068
Cdd:cd00159    157 KKLNEIVEFLIEN 169
MyTH4 pfam00784
MyTH4 domain; Domain in myosin and kinesin tails, present twice in myosin-VIIa, and also ...
 762-872 1.22e-36

MyTH4 domain; Domain in myosin and kinesin tails, present twice in myosin-VIIa, and also present in 3 other myosins.


Pssm-ID: 459939  Cd Length: 105  Bit Score: 133.47  E-value: 1.22e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431125025  762 ALEIATKGWSAQGLRDELYIQLCRQTTENFRLESLARGWELMAICLAFFPPTPKFHSYLEGYIYRHMDPvndtKGVAIST 841
Cdd:pfam00784    1 AQNILQKGLKRPELRDEIYCQLIKQTTNNPKPESLLRGWQLLALCLGTFPPSKKLLKYLLKFLKRHADD----PSREVGK 76

                           90       100       110
                   ....*....|....*....|....*....|.
gi 2431125025  842 YAKYCYHKLQKAALTGAKKglKKPNVEEIRH 872
Cdd:pfam00784   77 YAQFCLKRLKRTLKNGGRK--YPPSREEIEA 105
RhoGAP smart00324
GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac ...
 918-1068 1.41e-31

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.


Pssm-ID: 214618  Cd Length: 174  Bit Score: 121.60  E-value: 1.41e-31
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431125025   918 NGDQTEGIFRVPGDIDEVNALKLQVDQWKVPTGLE---DPHVPASLLKLWYRELEEPLIPHEFYEQCIA------HYESP 988
Cdd:smart00324   17 RGLDTEGIYRVSGSKSRVKELRDAFDSGPDPDLDLseyDVHDVAGLLKLFLRELPEPLITYELYEEFIEaakledETERL 96

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431125025   989 EAAVAVVHALPRINRMVLCYLIRFLQVFVQpaNVAITKMDVSNLAMVMAPNCLRCQSDDPRVIFENTRKeMSFLRVLIQH 1068
Cdd:smart00324   97 RALRELLSLLPPANRATLRYLLAHLNRVAE--HSEENKMTARNLAIVFGPTLLRPPDGEVASLKDIRHQ-NTVIEFLIEN 173
MyTH4 smart00139
Domain in Myosin and Kinesin Tails; Domain present twice in myosin-VIIa, and also present in 3 ...
 717-871 1.54e-31

Domain in Myosin and Kinesin Tails; Domain present twice in myosin-VIIa, and also present in 3 other myosins.


Pssm-ID: 214535  Cd Length: 152  Bit Score: 120.93  E-value: 1.54e-31
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431125025   717 WSSESIKKPMIVTSDRHVKKEACEIFKLIQMYMGDRRAKADPLHVAL--EIATKGWSAQGLRDELYIQLCRQTTENFRLE 794
Cdd:smart00139    1 YTKDPIKTSLLKLESDELQKEAVKIFKAILKFMGDIPLPRPDSHLDLvqFILQKGLDHPELRDEIYCQLIKQLTDNPSRQ 80

                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2431125025   795 SLARGWELMAICLAFFPPTPKFHSYLEGYIYRHMDPVNDTKgvaistYAKYCYHKLQKAALTGAKKglKKPNVEEIR 871
Cdd:smart00139   81 SEERGWQLLYLCTSLFPPSERLLPYLLQFLSRRADPGSEQG------LAKYCLYRLERTLKNGARK--QPPSRLELE 149
RhoGAP_ARHGAP22_24_25 cd04390
RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 882-1068 3.77e-25

RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for Rac1 and Cdc42. Short isoforms (without the PH domain) of ARHGAP24, called RC-GAP72 and p73RhoGAP, and of ARHGAP22, called p68RacGAP, has been shown to be involved in angiogenesis and endothelial cell capillary formation. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239855 [Multi-domain]  Cd Length: 199  Bit Score: 104.06  E-value: 3.77e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431125025  882 MFGSALQEVMSMQKeRYPDRQLPWVQTRLSEEVLAlNGDQTEGIFRVPGDIDEVNALKLQVDQWKVPT--GLEDPHVPAS 959
Cdd:cd04390      2 VFGQRLEDTVAYER-KFGPRLVPILVEQCVDFIRE-HGLKEEGLFRLPGQANLVKQLQDAFDAGERPSfdSDTDVHTVAS 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431125025  960 LLKLWYRELEEPLIPHEFYEQ---CIAHYESPEAA-----VAVVHALPRINRMVLCYLIRFLQVfVQpANVAITKMDVSN 1031
Cdd:cd04390     80 LLKLYLRELPEPVIPWAQYEDflsCAQLLSKDEEKglgelMKQVSILPKVNYNLLSYICRFLDE-VQ-SNSSVNKMSVQN 157

                          170       180       190
                   ....*....|....*....|....*....|....*..
gi 2431125025 1032 LAMVMAPNCLRCQSDDPRVIFENTRKEMSFLRVLIQH 1068
Cdd:cd04390    158 LATVFGPNILRPKVEDPATIMEGTPQIQQLMTVMISK 194
RhoGAP_nadrin cd04386
RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 881-1077 3.55e-21

RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been implicated in tight junction maintenance in mammalian epithelium. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239851  Cd Length: 203  Bit Score: 92.91  E-value: 3.55e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431125025  881 SMFGSALQEVMSMQKER--YPdrqlpwvqTRLSEEVLALNGDQTEGIFRVPGDIDEVNALKLQVDQWKVPTGLE----DP 954
Cdd:cd04386      3 PVFGTPLEEHLKRTGREiaLP--------IEACVMCLLETGMNEEGLFRVGGGASKLKRLKAALDAGTFSLPLDefysDP 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431125025  955 HVPASLLKLWYRELEEPLIPHEFYEQCIAHYESPE------AAVAVVHALPRINRMVLCYLIRFLQVFVQPANVaiTKMD 1028
Cdd:cd04386     75 HAVASALKSYLRELPDPLLTYNLYEDWVQAANKPDederlqAIWRILNKLPRENRDNLRYLIKFLSKLAQKSDE--NKMS 152

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 2431125025 1029 VSNLAMVMAPNCLrcqsddpRVIFENTRKEM---------SFLRVLIQHLDTSFMEGV 1077
Cdd:cd04386    153 PSNIAIVLAPNLL-------WAKNEGSLAEMaagtsvhvvAIVELIISHADWFFPGEV 203
RhoGAP-p50rhoGAP cd04404
RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 883-1073 5.86e-21

RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3). It is ubiquitously expressed and preferentially active on Cdc42. This subgroup also contains closely related ARHGAP8. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239869 [Multi-domain]  Cd Length: 195  Bit Score: 92.02  E-value: 5.86e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431125025  883 FGSALQEVmsmqKERYPDRQ-LPWVqTRLSEEVLALNGDQTEGIFRVPGDIDEVNALKLQVDQWKvP---TGLEDPHVPA 958
Cdd:cd04404      6 FGVSLQFL----KEKNPEQEpIPPV-VRETVEYLQAHALTTEGIFRRSANTQVVKEVQQKYNMGE-PvdfDQYEDVHLPA 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431125025  959 SLLKLWYRELEEPLIPHEFYE-----QCIAHYESPEAAVAVVHALPRINRMVLCYLIRFL-QVfvqPANVAITKMDVSNL 1032
Cdd:cd04404     80 VILKTFLRELPEPLLTFDLYDdivgfLNVDKEERVERVKQLLQTLPEENYQVLKYLIKFLvQV---SAHSDQNKMTNSNL 156

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*
gi 2431125025 1033 AMVMAPNCLRCQSDdprvifENTRKEM----SFLRVLIQHLDTSF 1073
Cdd:cd04404    157 AVVFGPNLLWAKDA------SMSLSAInpinTFTKFLLDHQDEIF 195
RhoGAP_ARHGAP18 cd04391
RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 882-1049 1.58e-17

RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP18-like proteins. The function of ArhGAP18 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239856  Cd Length: 216  Bit Score: 82.39  E-value: 1.58e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431125025  882 MFGSALQEVMSMQKERYPDRQLPWVQTRLSEEVLAlNGDQTEGIFRVPGDIDEVNALKLQVDQ--------WKVPTgled 953
Cdd:cd04391      1 LFGVPLSTLLERDQKKVPGSKVPLIFQKLINKLEE-RGLETEGILRIPGSAQRVKFLCQELEAkfyegtflWDQVK---- 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431125025  954 PHVPASLLKLWYRELEEPLIPHE----FYE-QCIAHYESPEAAVAV-VHALPRINRMVLCYLIRFLQVFVqpANVAITKM 1027
Cdd:cd04391     76 QHDAASLLKLFIRELPQPLLTVEylpaFYSvQGLPSKKDQLQALNLlVLLLPEANRDTLKALLEFLQKVV--DHEEKNKM 153

                          170       180
                   ....*....|....*....|..
gi 2431125025 1028 DVSNLAMVMAPNCLRCQSDDPR 1049
Cdd:cd04391    154 NLWNVAMIMAPNLFPPRGKHSK 175
RhoGAP_chimaerin cd04372
RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 902-1073 2.76e-17

RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms that each contain a C-terminal GAP domain, and a central C1 domain which binds phorbol esters, inducing a conformational change that activates the protein; one splice form is lacking the N-terminal Src homology-2 (SH2) domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239837 [Multi-domain]  Cd Length: 194  Bit Score: 81.41  E-value: 2.76e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431125025  902 QLPWVQTRLSEEVLAlNGDQTEGIFRVPGDIDEVNALKLQVDQWKVPTGL-----EDPHVPASLLKLWYRELEEPLIPHE 976
Cdd:cd04372     15 QRPMVVDMCIREIEA-RGLQSEGLYRVSGFAEEIEDVKMAFDRDGEKADIsatvyPDINVITGALKLYFRDLPIPVITYD 93

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431125025  977 FYEQCIA------HYESPEAAVAVVHALPRINRMVLCYLIRFLQVFVQpaNVAITKMDVSNLAMVMAPNCLRCQSDDPRV 1050
Cdd:cd04372     94 TYPKFIDaakisnPDERLEAVHEALMLLPPAHYETLRYLMEHLKRVTL--HEKDNKMNAENLGIVFGPTLMRPPEDSALT 171

                          170       180
                   ....*....|....*....|...
gi 2431125025 1051 IFENTRKEMSFLRVLIQHLDTSF 1073
Cdd:cd04372    172 TLNDMRYQILIVQLLITNEDVLF 194
RhoGAP_ARHGAP21 cd04395
RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 919-1073 2.09e-16

RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction complex. It has been shown to function as a GAP of Cdc42 and RhoA, and to interact with alpha-catenin and Arf6. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239860  Cd Length: 196  Bit Score: 78.60  E-value: 2.09e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431125025  919 GDQTEGIFRVPGDIDEVNALKLQVDQWKVPTGLEDP-----HVPASLLKLWYRELEEPLIPHEFYEQCIA--HYESPEAA 991
Cdd:cd04395     33 GLETVGIYRVPGNNAAISALQEELNRGGFDIDLQDPrwrdvNVVSSLLKSFFRKLPEPLFTNELYPDFIEanRIEDPVER 112

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431125025  992 VAV----VHALPRINRMVLCYLIRFLQVFVqpANVAITKMDVSNLAMVMAPNCLRCQSDDPRVIFENTRKEMSFLRVLIQ 1067
Cdd:cd04395    113 LKElrrlIHSLPDHHYETLKHLIRHLKTVA--DNSEVNKMEPRNLAIVFGPTLVRTSDDNMETMVTHMPDQCKIVETLIQ 190


                   ....*.
gi 2431125025 1068 HLDTSF 1073
Cdd:cd04395    191 HYDWFF 196
RhoGAP-ARHGAP11A cd04394
RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 922-1069 2.62e-16

RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP11A-like proteins. The mouse homolog of human ArhGAP11A has been detected as a gene exclusively expressed in immature ganglion cells, potentially playing a role in retinal development. The exact function of ArhGAP11A is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239859 [Multi-domain]  Cd Length: 202  Bit Score: 78.67  E-value: 2.62e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431125025  922 TEGIFRVPGDIDEVNALKLQVDQWKVPTGLEDPHVPASLLKLWYRELEEPLIP---HEFYEQCI---AHYESPEAAVAVV 995
Cdd:cd04394     37 TEGLFRKSGSVVRQKELKAKLEGGEACLSSALPCDVAGLLKQFFRELPEPLLPydlHEALLKAQelpTDEERKSATLLLT 116

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2431125025  996 HALPRINRMVLCYLIRFLQVFVQpaNVAITKMDVSNLAMVMAPNCLRCqSDDPRVIFENTRKEMSFLRVLIQHL 1069
Cdd:cd04394    117 CLLPDEHVNTLRYFFSFLYDVAQ--RCSENKMDSSNLAVIFAPNLFQS-EEGGEKMSSSTEKRLRLQAAVVQTL 187
RhoGAP_ARHGAP20 cd04402
RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 882-1068 1.08e-15

RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP20-like proteins. ArhGAP20, also known as KIAA1391 and RA-RhoGAP, contains a RhoGAP, a RA, and a PH domain, and ANXL repeats. ArhGAP20 is activated by Rap1 and induces inactivation of Rho, which in turn leads to neurite outgrowth. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239867  Cd Length: 192  Bit Score: 76.57  E-value: 1.08e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431125025  882 MFGSALQEVMsmqkeryPDRQLPW-VQTRLSeeVLALNGDQTEGIFRVPGDIDEVNALKLQVDqwkvpTGLEDP------ 954
Cdd:cd04402      1 LFGQPLSNIC-------EDDNLPKpILDMLS--LLYQKGPSTEGIFRRSANAKACKELKEKLN-----SGVEVDlkaepv 66

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431125025  955 HVPASLLKLWYRELEEPLIPHEFYEQCIAHYESP------EAAVAVVHALPRINRMVLCYLIRFLQVFVQPANVaiTKMD 1028
Cdd:cd04402     67 LLLASVLKDFLRNIPGSLLSSDLYEEWMSALDQEneeekiAELQRLLDKLPRPNVLLLKHLICVLHNISQNSET--NKMD 144

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|
gi 2431125025 1029 VSNLAMVMAPNCLrCQSDDPRVIFENTRKEMSFLRVLIQH 1068
Cdd:cd04402    145 AFNLAVCIAPSLL-WPPASSELQNEDLKKVTSLVQFLIEN 183
RhoGAP_myosin_IX cd04377
RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 900-1048 1.14e-15

RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a RhoGAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239842  Cd Length: 186  Bit Score: 76.32  E-value: 1.14e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431125025  900 DRQLPWVQTRLSEEVlALNGDQTEGIFRVPGDIDEVNALKLQVDQWKVPTGLED--PHVPASLLKLWYRELEEPLIPHEF 977
Cdd:cd04377     12 DRSVPLVLEKLLEHI-EMHGLYTEGIYRKSGSANKIKELRQGLDTDPDSVNLEDypIHVITSVLKQWLRELPEPLMTFEL 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431125025  978 YEQCIAHYESPE------AAVAVVHALPRINRMVLCYLIRFLqvfvqpANVA----ITKMDVSNLAMVMAPNCLRCQ-SD 1046
Cdd:cd04377     91 YENFLRAMELEEkqervrALYSVLEQLPRANLNTLERLIFHL------VRVAlqeeVNRMSANALAIVFAPCILRCPdTA 164


                   ..
gi 2431125025 1047 DP 1048
Cdd:cd04377    165 DP 166
RhoGAP_MgcRacGAP cd04382
RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 919-1073 1.91e-15

RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in MgcRacGAP proteins. MgcRacGAP plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin MKLP1, which is critical for the structure of the central spindle by promoting microtuble bundling. ii) after phosphorylation by aurora B MgcRacGAP becomes an effective regulator of RhoA and plays an important role in the assembly of the contractile ring and the initiation of cytokinesis. MgcRacGAP-like proteins contain a N-terminal C1-like domain, and a C-terminal RhoGAP domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239847  Cd Length: 193  Bit Score: 75.79  E-value: 1.91e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431125025  919 GDQTEGIFRVPGDIDEVNALKLQVDQWK-VPT-GLEDPHVPASLLKLWYRELEEPLIP---HEFYEQCIAHYESPEAAVA 993
Cdd:cd04382     32 GLTEEGLYRVSGSEREVKALKEKFLRGKtVPNlSKVDIHVICGCLKDFLRSLKEPLITfalWKEFMEAAEILDEDNSRAA 111

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431125025  994 ---VVHALPRINRMVLCYLIRFLQVFVQ-PANvaitKMDVSNLAMVMAPNCLRCQSDDPR--VIFENTRKEMSFLRVLIq 1067
Cdd:cd04382    112 lyqAISELPQPNRDTLAFLILHLQRVAQsPEC----KMDINNLARVFGPTIVGYSVPNPDpmTILQDTVRQPRVVERLL- 186


                   ....*.
gi 2431125025 1068 HLDTSF 1073
Cdd:cd04382    187 EIPSDY 192
RhoGAP_FAM13A1a cd04393
RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 882-1046 4.02e-15

RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by up several orders of magnitude.


Pssm-ID: 239858 [Multi-domain]  Cd Length: 189  Bit Score: 74.81  E-value: 4.02e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431125025  882 MFGSALQEVmsmQKERYPDRQLPWVQTRLSEeVLALNGDQTEGIFRVPGDIDEVNALKLQVDQwKVPTGLE---DPHVPA 958
Cdd:cd04393      2 VFGVPLQEL---QQAGQPENGVPAVVRHIVE-YLEQHGLEQEGLFRVNGNAETVEWLRQRLDS-GEEVDLSkeaDVCSAA 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431125025  959 SLLKLWYRELEEPLIPHE-------FYEQCIAHYESPEAAVAVVHALPRINRMVLCYLIRFLqvfvqpANVA----ITKM 1027
Cdd:cd04393     77 SLLRLFLQELPEGLIPASlqirlmqLYQDYNGEDEFGRKLRDLLQQLPPVNYSLLKFLCHFL------SNVAsqhhENRM 150

                          170
                   ....*....|....*....
gi 2431125025 1028 DVSNLAMVMAPNCLRCQSD 1046
Cdd:cd04393    151 TAENLAAVFGPDVFHVYTD 169
RhoGAP_ARHGAP27_15_12_9 cd04403
RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 883-1042 3.44e-14

RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are studied show GAP activity towards Rac1, some additionally show activity towards Cdc42. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239868 [Multi-domain]  Cd Length: 187  Bit Score: 72.04  E-value: 3.44e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431125025  883 FGSALQEVMSMQKERypdrqLPWVqTRLSEEVLALNGDQTEGIFRVPGDIDEVNALKLQVDQ----WKVPTGLEDPHVPA 958
Cdd:cd04403      1 FGCHLEALCQRENST-----VPKF-VRLCIEAVEKRGLDVDGIYRVSGNLAVIQKLRFAVDHdeklDLDDSKWEDIHVIT 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431125025  959 SLLKLWYRELEEPLIPHEFYEQCIAHYESPEAAVAV------VHALPRINRMVLCYLIRFLQVFVQPANVaiTKMDVSNL 1032
Cdd:cd04403     75 GALKLFFRELPEPLFPYSLFNDFVAAIKLSDYEQRVsavkdlIKSLPKPNHDTLKMLFRHLCRVIEHGEK--NRMTTQNL 152

                          170
                   ....*....|
gi 2431125025 1033 AMVMAPNCLR 1042
Cdd:cd04403    153 AIVFGPTLLR 162
RhoGAP_fRGD1 cd04398
RhoGAP_fRGD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 913-1047 1.75e-13

RhoGAP_fRGD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal RGD1-like proteins. Yeast Rgd1 is a GAP protein for Rho3 and Rho4 and plays a role in low-pH response. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239863  Cd Length: 192  Bit Score: 70.12  E-value: 1.75e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431125025  913 EVLALNGDQTEGIFRVPGDIDEVNALKLQVDqwKVPTG---------LEDPHVPASLLKLWYRELEEPLIPHEFYEQCI- 982
Cdd:cd04398     25 QAIENFGLNLEGIYRLSGNVSRVNKLKELFD--KDPLNvllispedyESDIHSVASLLKLFFRELPEPLLTKALSREFIe 102

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431125025  983 -AHYESP----EAAVAVVHALPRINRMVLCYLIRFLQVFVQpaNVAITKMDVSNLAMVMAPNCLRCQSDD 1047
Cdd:cd04398    103 aAKIEDEsrrrDALHGLINDLPDANYATLRALMFHLARIKE--HESVNRMSVNNLAIIWGPTLMNAAPDN 170
RhoGAP_ARHGAP6 cd04376
RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 919-1074 6.77e-13

RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP6-like proteins. ArhGAP6 shows GAP activity towards RhoA, but not towards Cdc42 and Rac1. ArhGAP6 is often deleted in microphthalmia with linear skin defects syndrome (MLS); MLS is a severe X-linked developmental disorder. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239841  Cd Length: 206  Bit Score: 68.62  E-value: 6.77e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431125025  919 GDQTEGIFRVPGDIDEVNALKLQVDQWKvPTGLED---PHVPASLLKLWYRELEEPLIPHEFYE-----QCIAHYESPEA 990
Cdd:cd04376     24 GLQTVGIFRVGSSKKRVRQLREEFDRGI-DVVLDEnhsVHDVAALLKEFFRDMPDPLLPRELYTafigtALLEPDEQLEA 102

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431125025  991 AVAVVHALPRINRMVLCYLIRFLQVFVQPANVAI---------TKMDVSNLAMVMAPNCLRCQSDDPRVI------FENT 1055
Cdd:cd04376    103 LQLLIYLLPPCNCDTLHRLLKFLHTVAEHAADSIdedgqevsgNKMTSLNLATIFGPNLLHKQKSGEREFvqaslrIEES 182

                          170
                   ....*....|....*....
gi 2431125025 1056 RKEMSFLRVLIQHLDTSFM 1074
Cdd:cd04376    183 TAIINVVQTMIDNYEELFM 201
RhoGAP_OCRL1 cd04380
RhoGAP_OCRL1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 876-1072 7.45e-13

RhoGAP_OCRL1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in OCRL1-like proteins. OCRL1 (oculocerebrorenal syndrome of Lowe 1)-like proteins contain two conserved domains: a central inositol polyphosphate 5-phosphatase domain and a C-terminal Rho GAP domain, this GAP domain lacks the catalytic residue and therefore maybe inactive. OCRL-like proteins are type II inositol polyphosphate 5-phosphatases that can hydrolyze lipid PI(4,5)P2 and PI(3,4,5)P3 and soluble Ins(1,4,5)P3 and Ins(1,3,4,5)P4, but their individual specificities vary. The functionality of the RhoGAP domain is still unclear. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239845  Cd Length: 220  Bit Score: 68.91  E-value: 7.45e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431125025  876 AVFSPSMFGSALQEVMSMQK--ERYPDRQL------PWVQTRLS---E-----EVLALNGDQTEGIFRVPGDIDEVNALK 939
Cdd:cd04380      6 GVYLPSCFGSSLETLIRLPDpgIRNLIDQLelgdnpDYSEVPLSipkEiwrlvDYLYTRGLAQEGLFEEPGLPSEPGELL 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431125025  940 LQV----DQWKVPTGLEDPHVPASLLKLWYRELEEPLIPHEFYEQCIAHYESP-EAAVAVV-HALPRINRMVLCYLIRFL 1013
Cdd:cd04380     86 AEIrdalDTGSPFNSPGSAESVAEALLLFLESLPDPIIPYSLYERLLEAVANNeEDKRQVIrISLPPVHRNVFVYLCSFL 165

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2431125025 1014 QVFVqpANVAITKMDVSNLAMVMAPNCLRCQSDDPRVIFENTRKEMSflRVLIQHLDTS 1072
Cdd:cd04380    166 RELL--SESADRGLDENTLATIFGRVLLRDPPRAGGKERRAERDRKR--AFIEQFLLND 220
RhoGAP_myosin_IXB cd04407
RhoGAP_myosin_IXB: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 890-1067 1.44e-12

RhoGAP_myosin_IXB: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXB. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239872 [Multi-domain]  Cd Length: 186  Bit Score: 67.32  E-value: 1.44e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431125025  890 VMSMQKERYPdrqLPWVQTRLSEEVlALNGDQTEGIFRVPGDIDEVNALK--LQVDQWKVPtgLED-P-HVPASLLKLWY 965
Cdd:cd04407      5 VGSLTSNKTS---VPIVLEKLLEHV-EMHGLYTEGIYRKSGSANRMKELHqlLQADPENVK--LENyPiHAITGLLKQWL 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431125025  966 RELEEPLIPHEFYEQCIAHYESPE------AAVAVVHALPRINRMVLCYLIRFLqvfVQPANVA-ITKMDVSNLAMVMAP 1038
Cdd:cd04407     79 RELPEPLMTFAQYNDFLRAVELPEkqeqlqAIYRVLEQLPTANHNTLERLIFHL---VKVALEEdVNRMSPNALAIVFAP 155

                          170       180       190
                   ....*....|....*....|....*....|
gi 2431125025 1039 NCLRC-QSDDPRVIFENTRKEMSFLRVLIQ 1067
Cdd:cd04407    156 CLLRCpDSSDPLTSMKDVAKTTTCVEMLIK 185
RhoGAP_srGAP cd04383
RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 914-1042 2.74e-12

RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs contain an N-terminal FCH domain, a central RhoGAP domain and a C-terminal SH3 domain; this SH3 domain interacts with the intracellular proline-rich-tail of the Roundabout receptor (Robo). This interaction with Robo then activates the rhoGAP domain which in turn inhibits Cdc42 activity. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239848  Cd Length: 188  Bit Score: 66.68  E-value: 2.74e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431125025  914 VLALNGDQTEGIFRVPGDIDEVNALKLQVDQWKVP-TGLEDPH---VPASLLKLWYRELEEPLIPHEFYEQCI--AHYES 987
Cdd:cd04383     28 FINLYGLQHQGIFRVSGSQVEVNDIKNAFERGEDPlADDQNDHdinSVAGVLKLYFRGLENPLFPKERFEDLMscVKLEN 107

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2431125025  988 PEAAV----AVVHALPRINRMVLCYLIRFLQVFVQPANVAItkMDVSNLAMVMAPNCLR 1042
Cdd:cd04383    108 PTERVhqirEILSTLPRSVIIVMRYLFAFLNHLSQFSDENM--MDPYNLAICFGPTLMP 164
RhoGAP_fBEM3 cd04400
RhoGAP_fBEM3: RhoGAP (GTPase-activator [GAP] protein for Rho-like small GTPases) domain of ...
 883-1038 6.50e-12

RhoGAP_fBEM3: RhoGAP (GTPase-activator [GAP] protein for Rho-like small GTPases) domain of fungal BEM3-like proteins. Bem3 is a GAP protein of Cdc42, and is specifically involved in the control of the initial assembly of the septin ring in yeast bud formation. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239865 [Multi-domain]  Cd Length: 190  Bit Score: 65.46  E-value: 6.50e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431125025  883 FGSALQEVMSMQKERYPDRQLPWVQTRLSEEVLALNGDQTEGIFRVPGDIDEVNALKLQ----VDQWKVPTGLE-DPHVP 957
Cdd:cd04400      2 FGSPLEEAVELSSHKYNGRDLPSVVYRCIEYLDKNRAIYEEGIFRLSGSASVIKQLKERfnteYDVDLFSSSLYpDVHTV 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431125025  958 ASLLKLWYRELEEPLIP---HEFYEQCIAHYESPEAAVA----VVHALPRINRMVLCYLIRFLQVFVQpaNVAITKMDVS 1030
Cdd:cd04400     82 AGLLKLYLRELPTLILGgelHNDFKRLVEENHDRSQRALelkdLVSQLPQANYDLLYVLFSFLRKIIE--HSDVNKMNLR 159


                   ....*...
gi 2431125025 1031 NLAMVMAP 1038
Cdd:cd04400    160 NVCIVFSP 167
RhoGAP_fLRG1 cd04397
RhoGAP_fLRG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 923-1071 3.45e-11

RhoGAP_fLRG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal LRG1-like proteins. Yeast Lrg1p is required for efficient cell fusion, and mother-daughter cell separation, possibly through acting as a RhoGAP specifically regulating 1,3-beta-glucan synthesis. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239862  Cd Length: 213  Bit Score: 63.92  E-value: 3.45e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431125025  923 EGIFRVPGDIDEVNALKLQVDqwKVPTGLED-----PHVPASLLKLWYRELEEPLIPHEFYEQCI--AHYESPEAAVAVV 995
Cdd:cd04397     46 EGVFRKNGNIRRLKELTEEID--KNPTEVPDlskenPVQLAALLKKFLRELPDPLLTFKLYRLWIssQKIEDEEERKRVL 123

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431125025  996 H----ALPRINRMVLCYLIRFLQ---VFVQPANVAITKMDVSNLAMVMAPNCLRCQSDDPrvifeNTRKEmSFLRV---- 1064
Cdd:cd04397    124 HlvycLLPKYHRDTMEVLFSFLKwvsSFSHIDEETGSKMDIHNLATVITPNILYSKTDNP-----NTGDE-YFLAIeavn 197


                   ....*...
gi 2431125025 1065 -LIQHLDT 1071
Cdd:cd04397    198 yLIENNEE 205
RhoGAP_Bcr cd04387
RhoGAP_Bcr: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr ...
 902-1042 1.13e-10

RhoGAP_Bcr: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr (breakpoint cluster region protein)-like proteins. Bcr is a multidomain protein with a variety of enzymatic functions. It contains a RhoGAP and a Rho GEF domain, a Ser/Thr kinase domain, an N-terminal oligomerization domain, and a C-terminal PDZ binding domain, in addition to PH and C2 domains. Bcr is a negative regulator of: i) RacGTPase, via the Rho GAP domain, ii) the Ras-Raf-MEK-ERK pathway, via phosphorylation of the Ras binding protein AF-6, and iii) the Wnt signaling pathway through binding beta-catenin. Bcr can form a complex with beta-catenin and Tcf1. The Wnt signaling pathway is involved in cell proliferation, differentiation, and cell renewal. Bcr was discovered as a fusion partner of Abl. The Bcr-Abl fusion is characteristic for a large majority of chronic myelogenous leukemias (CML). Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239852 [Multi-domain]  Cd Length: 196  Bit Score: 62.25  E-value: 1.13e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431125025  902 QLPWVQTRLSEEVlALNGDQTEGIFRVPGDIDEVNALK--LQVDQWKVPTGLEDPHVPA--SLLKLWYRELEEPLIPHEF 977
Cdd:cd04387     15 KVPYIVRQCVEEV-ERRGMEEVGIYRISGVATDIQALKaaFDTNNKDVSVMLSEMDVNAiaGTLKLYFRELPEPLFTDEL 93

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2431125025  978 YEQCIAHYESPEAAV------AVVHALPRINRMVLCYLIRFLQVFVQpaNVAITKMDVSNLAMVMAPNCLR 1042
Cdd:cd04387     94 YPNFAEGIALSDPVAkescmlNLLLSLPDPNLVTFLFLLHHLKRVAE--REEVNKMSLHNLATVFGPTLLR 162
RhoGAP_CdGAP cd04384
RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 923-1042 4.24e-10

RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP is recruited to focal adhesions via the interaction with the scaffold protein actopaxin (alpha-parvin). Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239849 [Multi-domain]  Cd Length: 195  Bit Score: 60.21  E-value: 4.24e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431125025  923 EGIFRVPGDIDEVNALKLQVDQWKVP-----TGLEDPHVPASLLKLWYRELEEPLIPHEFYE---QCIAHYESPEAAVA- 993
Cdd:cd04384     36 DGIYRLSGIASNIQRLRHEFDSEQIPdltkdVYIQDIHSVSSLCKLYFRELPNPLLTYQLYEkfsEAVSAASDEERLEKi 115

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2431125025  994 --VVHALPRINRMVLCYLIRFLQVFVQpaNVAITKMDVSNLAMVMAPNCLR 1042
Cdd:cd04384    116 hdVIQQLPPPHYRTLEFLMRHLSRLAK--YCSITNMHAKNLAIVWAPNLLR 164
RhoGAP_ARAP cd04385
RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 919-1068 6.99e-10

RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity is PIP3-dependent, ARAPs are considered integration points for phosphoinositide, Arf and Rho signaling. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239850  Cd Length: 184  Bit Score: 59.63  E-value: 6.99e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431125025  919 GDQTEGIFRVPGDIDEVNAL--KLQVDQWKVP--TGLEDPHVPASLLKLWYRELEEPLIPHEFYEQCI--AHYESPEAAV 992
Cdd:cd04385     30 GLMSEGIYRKNGKNSSVKKLleAFRKDARSVQlrEGEYTVHDVADVLKRFLRDLPDPLLTSELHAEWIeaAELENKDERI 109

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431125025  993 A----VVHALPRINRMVLCYLIRFLqVFVQpANVAITKMDVSNLAMVMAPnCLrCQSDDPRVifENTRKEMSFLRVLIQH 1068
Cdd:cd04385    110 ArykeLIRRLPPINRATLKVLIGHL-YRVQ-KHSDENQMSVHNLALVFGP-TL-FQTDEHSV--GQTSHEVKVIEDLIDN 183
RhoGAP_fSAC7_BAG7 cd04396
RhoGAP_fSAC7_BAG7: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 918-1070 7.84e-10

RhoGAP_fSAC7_BAG7: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal SAC7 and BAG7-like proteins. Both proteins are GTPase activating proteins of Rho1, but differ functionally in vivo: SAC7, but not BAG7, is involved in the control of Rho1-mediated activation of the PKC-MPK1 pathway. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239861  Cd Length: 225  Bit Score: 60.12  E-value: 7.84e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431125025  918 NGDQTEGIFRVPGDIDEVNALKLQVDqwKVP---TGLEDP----HVPASLLKLWYRELEEPLIPHEFYEQ---------C 981
Cdd:cd04396     46 NATEVEGIFRVAGSSKRIRELQLIFS--TPPdygKSFDWDgytvHDAASVLRRYLNNLPEPLVPLDLYEEfrnplrkrpR 123

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431125025  982 IAHY----------ESPEAAV----AVVHALPRINRMVLCYLIRFLQVFVqpANVAITKMDVSNLAMVMAPNCLRCQSDD 1047
Cdd:cd04396    124 ILQYmkgrineplnTDIDQAIkeyrDLITRLPNLNRQLLLYLLDLLAVFA--RNSDKNLMTASNLAAIFQPGILSHPDHE 201

                          170       180
                   ....*....|....*....|...
gi 2431125025 1048 prVIFENTRKEMSFLRVLIQHLD 1070
Cdd:cd04396    202 --MDPKEYKLSRLVVEFLIEHQD 222
RhoGAP_myosin_IXA cd04406
RhoGAP_myosin_IXA: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 900-1066 8.21e-10

RhoGAP_myosin_IXA: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXA. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239871  Cd Length: 186  Bit Score: 59.24  E-value: 8.21e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431125025  900 DRQLPWVQTRLSEEVlALNGDQTEGIFRVPGDIDEVNALKLQVDQWKVPTGLED--PHVPASLLKLWYRELEEPLIPHEF 977
Cdd:cd04406     12 DRSVPLVVEKLINYI-EMHGLYTEGIYRKSGSTNKIKELRQGLDTDANSVNLDDynIHVIASVFKQWLRDLPNPLMTFEL 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431125025  978 YEQ---CIAHYESPEAAVAVVHALPRINRMVLCYLIRFLQVFVQPA-NVAITKMDVSNLAMVMAPNCLRC-QSDDPRVIF 1052
Cdd:cd04406     91 YEEflrAMGLQERRETVRGVYSVIDQLSRTHLNTLERLIFHLVRIAlQEETNRMSANALAIVFAPCILRCpDTTDPLQSV 170

                          170
                   ....*....|....
gi 2431125025 1053 ENTRKEMSFLRVLI 1066
Cdd:cd04406    171 QDISKTTTCVELIV 184
RhoGAP_Graf cd04374
RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase ...
 913-1046 1.81e-09

RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal changes mediated by Rho proteins. Graf exhibits GAP activity toward RhoA and Cdc42, but only weakly activates Rac1. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239839  Cd Length: 203  Bit Score: 58.56  E-value: 1.81e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431125025  913 EVLALNGDQTEGIFRVPGDIDEVNAL-KLQVDQWKV-PTGLEDPHVP------ASLLKLWYRELEEPLIPHEFYEQCI-- 982
Cdd:cd04374     37 EAVETRGINEQGLYRVVGVNSKVQKLlSLGLDPKTStPGDVDLDNSEweiktiTSALKTYLRNLPEPLMTYELHNDFIna 116

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2431125025  983 AHYESPEAAV----AVVHALPRINRMVLCYLIRFLqvfvqpANVAI----TKMDVSNLAMVMAPNCLRCQSD 1046
Cdd:cd04374    117 AKSENLESRVnaihSLVHKLPEKNREMLELLIKHL------TNVSDhskkNLMTVSNLGVVFGPTLLRPQEE 182
RhoGap_RalBP1 cd04381
RhoGap_RalBP1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 919-1038 4.90e-09

RhoGap_RalBP1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in RalBP1 proteins, also known as RLIP, RLIP76 or cytocentrin. RalBP1 plays an important role in endocytosis during interphase. During mitosis, RalBP1 transiently associates with the centromere and has been shown to play an essential role in the proper assembly of the mitotic apparatus. RalBP1 is an effector of the Ral GTPase which itself is an effector of Ras. RalBP1 contains a RhoGAP domain, which shows weak activity towards Rac1 and Cdc42, but not towards Ral, and a Ral effector domain binding motif. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239846 [Multi-domain]  Cd Length: 182  Bit Score: 57.06  E-value: 4.90e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431125025  919 GDQTEGIFRVPGDIDEVNALKLQVDQWKVPTGLE-DPHVPASLLKLWYRELEEPLIPHE----FYEQCIAHYESPEAA-- 991
Cdd:cd04381     35 GMKCEGIYKVSGIKSKVDELKAAYNRRESPNLEEyEPPTVASLLKQYLRELPEPLLTKElmprFEEACGRPTEAEREQel 114

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 2431125025  992 VAVVHALPRINRMVLCYLIRFLQVFVQPAnvAITKMDVSNLAMVMAP 1038
Cdd:cd04381    115 QRLLKELPECNRLLLAWLIVHMDHVIAQE--LETKMNIQNISIVLSP 159
RhoGAP_DLC1 cd04375
RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 881-1038 6.41e-09

RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START (StAR-related lipid transfer action) domain. DLC1 has tumor suppressor activity in cell culture. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239840  Cd Length: 220  Bit Score: 57.43  E-value: 6.41e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431125025  881 SMFGSALqeVMSMQKERYPdrqLPwVQTRLSEEVLALNGDQTEGIFRVPGDIDEVNALKLQVDQWKVPTGLEDPHV--PA 958
Cdd:cd04375      3 NVFGVPL--LVNLQRTGQP---LP-RSIQQAMRWLRNNALDQVGLFRKSGVKSRIQKLRSMIESSTDNVNYDGQQAydVA 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431125025  959 SLLKLWYRELEEPLIPHEFYE------QCIAHYESPEAAVAVVHALPRINRMVLCYLIRFLQVFVqpANVAITKMDVSNL 1032
Cdd:cd04375     77 DMLKQYFRDLPEPLLTNKLSEtfiaifQYVPKEQRLEAVQCAILLLPDENREVLQTLLYFLSDVA--ANSQENQMTATNL 154


                   ....*.
gi 2431125025 1033 AMVMAP 1038
Cdd:cd04375    155 AVCLAP 160
RhoGAP_p190 cd04373
RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 891-1042 4.19e-07

RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p190-like proteins. p190, also named RhoGAP5, plays a role in neuritogenesis and axon branch stability. p190 shows a preference for Rho, over Rac and Cdc42, and consists of an N-terminal GTPase domain and a C-terminal GAP domain. The central portion of p190 contains important regulatory phosphorylation sites. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239838  Cd Length: 185  Bit Score: 51.30  E-value: 4.19e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431125025  891 MSMQKERYPDRQLPWVQTRLSEEVLAlNGDQTEGIFRVPGDIDEVNALKLQVDQWKvPTGLEDPHVP----ASLLKLWYR 966
Cdd:cd04373      3 VPLANVVTSEKPIPIFLEKCVEFIEA-TGLETEGIYRVSGNKTHLDSLQKQFDQDH-NLDLVSKDFTvnavAGALKSFFS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431125025  967 ELEEPLIPHEFYEQCIAHYESPE------AAVAVVHALPRINRMVLCYLIRFLQVFVQpaNVAITKMDVSNLAMVMAPNC 1040
Cdd:cd04373     81 ELPDPLIPYSMHLELVEAAKINDreqrlhALKELLKKFPPENFDVFKYVITHLNKVSQ--NSKVNLMTSENLSICFWPTL 158


                   ..
gi 2431125025 1041 LR 1042
Cdd:cd04373    159 MR 160
RhoGAP_GMIP_PARG1 cd04378
RhoGAP_GMIP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 897-1042 3.47e-06

RhoGAP_GMIP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP (Gem interacting protein) and PARG1 (PTPL1-associated RhoGAP1). GMIP plays important roles in neurite growth and axonal guidance, and interacts with Gem, a member of the RGK subfamily of the Ras small GTPase superfamily, through the N-terminal half of the protein. GMIP contains a C-terminal RhoGAP domain. GMIP inhibits RhoA function, but is inactive towards Rac1 and Cdc41. PARG1 interacts with Rap2, also a member of the Ras small GTPase superfamily whose exact function is unknown, and shows strong preference for Rho. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239843  Cd Length: 203  Bit Score: 48.96  E-value: 3.47e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431125025  897 RYPDrQLPWVQTRLSEEV--LALNgdqTEGIFRVPGDIDEVNAL-------KLQVDqwkvptgLED--PHVPASLLKLWY 965
Cdd:cd04378     11 DFPD-EVPFIIKKCTSEIenRALG---VQGIYRVSGSKARVEKLcqafengKDLVE-------LSElsPHDISSVLKLFL 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431125025  966 RELEEPLIPHEFYEQCIA-------------HYESPEAAVAVVHA-------LPRINRMVLCYLIRFLQVFVQPANVaiT 1025
Cdd:cd04378     80 RQLPEPLILFRLYNDFIAlakeiqrdteedkAPNTPIEVNRIIRKlkdllrqLPASNYNTLQHLIAHLYRVAEQFEE--N 157

                          170
                   ....*....|....*..
gi 2431125025 1026 KMDVSNLAMVMAPNCLR 1042
Cdd:cd04378    158 KMSPNNLGIVFGPTLIR 174
RhoGAP_SYD1 cd04379
RhoGAP_SYD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 883-1049 3.65e-06

RhoGAP_SYD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in SYD-1_like proteins. Syd-1, first identified and best studied in C.elegans, has been shown to play an important role in neuronal development by specifying axonal properties. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239844  Cd Length: 207  Bit Score: 49.00  E-value: 3.65e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431125025  883 FGSALQEVMsmQKERyPDRQLPWVQTRLSEEVlALNGDQTEGIFRVPGDIDEVNALKLQVDQWKVPTGLEDPHVP----- 957
Cdd:cd04379      1 FGVPLSRLV--EREG-ESRDVPIVLQKCVQEI-ERRGLDVIGLYRLCGSAAKKKELRDAFERNSAAVELSEELYPdinvi 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431125025  958 ASLLKLWYRELEEPLIPHEFYEQCI--AHYESP-------EAAVAVVHALPRINRMVLCYLIRFLQVFVqpANVAITKMD 1028
Cdd:cd04379     77 TGVLKDYLRELPEPLITPQLYEMVLeaLAVALPndvqtntHLTLSIIDCLPLSAKATLLLLLDHLSLVL--SNSERNKMT 154

                          170       180
                   ....*....|....*....|.
gi 2431125025 1029 VSNLAMVMAPNCLRCQSDDPR 1049
Cdd:cd04379    155 PQNLAVCFGPVLMFCSQEFSR 175
RhoGAP_GMIP cd04408
RhoGAP_GMIP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP ...
 894-1042 5.61e-06

RhoGAP_GMIP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP (Gem interacting protein). GMIP plays important roles in neurite growth and axonal guidance, and interacts with Gem, a member of the RGK subfamily of the Ras small GTPase superfamily, through the N-terminal half of the protein. GMIP contains a C-terminal RhoGAP domain. GMIP inhibits RhoA function, but is inactive towards Rac1 and Cdc41. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239873  Cd Length: 200  Bit Score: 48.27  E-value: 5.61e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431125025  894 QKERYPDRQLPWVQTRLSEEVLALNGDQtEGIFRVPGDIDEVNALKLQVDQWKVPTGLED--PHVPASLLKLWYRELEEP 971
Cdd:cd04408      7 QLPRDFPEEVPFVVVRCTAEIENRALGV-QGIYRISGSKARVEKLCQAFENGRDLVDLSGhsPHDITSVLKHFLKELPEP 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431125025  972 LIPHEFYEQCIA-----------HYESPEAAVAVVHA-------LPRINRMVLCYLIRFLqvFVQPANVAITKMDVSNLA 1033
Cdd:cd04408     86 VLPFQLYDDFIAlakelqrdsekAAESPSIVENIIRSlkellgrLPVSNYNTLRHLMAHL--YRVAERFEDNKMSPNNLG 163


                   ....*....
gi 2431125025 1034 MVMAPNCLR 1042
Cdd:cd04408    164 IVFGPTLLR 172
RhoGAP_ARHGAP19 cd04392
RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 922-1068 9.48e-06

RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP19-like proteins. The function of ArhGAP19 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239857  Cd Length: 208  Bit Score: 47.84  E-value: 9.48e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431125025  922 TEGIFRVPGDIDEVNALKLQVDQwKVPTGLED----PHVPASLLKLWYRELEEPLIPHEFY--------------EQCIA 983
Cdd:cd04392     26 VEGLFRKPGNSARQQELRDLLNS-GTDLDLESggfhAHDCATVLKGFLGELPEPLLTHAHYpahlqiadlcqfdeKGNKT 104

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431125025  984 HYESPEAAVAVVH----ALPRINRMVLCYLIRFLQVFVQpaNVAITKMDVSNLAMVMAPNCLRCQSDDPRVIFENTRKEM 1059
Cdd:cd04392    105 SAPDKERLLEALQllllLLPEENRNLLKLILDLLYQTAK--HEDKNKMSADNLALLFTPHLICPRNLTPEDLHENAQKLN 182


                   ....*....
gi 2431125025 1060 SFLRVLIQH 1068
Cdd:cd04392    183 SIVTFMIKH 191
RhoGAP_fRGD2 cd04399
RhoGAP_fRGD2: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 934-1075 1.51e-03

RhoGAP_fRGD2: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal RGD2-like proteins. Yeast Rgd2 is a GAP protein for Cdc42 and Rho5. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239864  Cd Length: 212  Bit Score: 41.16  E-value: 1.51e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431125025  934 EVNALKLQVDQWKVP-------TGLEDPHVpASLLKLWYRELEEPLIPHEFYEQCIAHY--------ESPEAAVAVVHA- 997
Cdd:cd04399     52 ETHQLRNLLNKPKKPdkeviilKKFEPSTV-ASVLKLYLLELPDSLIPHDIYDLIRSLYsayppsqeDSDTARIQGLQSt 130

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431125025  998 ---LPRINRMVLCYLIRFLQVFVQpanvaITKM------DVSNLAMVMAPNCLRCQSDDPRVIfeNTRKEMSFLRVLIQH 1068
Cdd:cd04399    131 lsqLPKSHIATLDAIITHFYRLIE-----ITKMgeseeeYADKLATSLSREILRPIIESLLTI--GDKHGYKFFRDLLTH 203


                   ....*..
gi 2431125025 1069 LDTSFME 1075
Cdd:cd04399    204 KDQIFSE 210
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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