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Conserved domains on  [gi|2429714623|ref|NP_001403123|]
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lipase maturation factor 2 isoform 5 [Mus musculus]

Protein Classification

lipase maturation factor family protein( domain architecture ID 10535984)

lipase maturation factor family protein similar to vertebrate lipase maturation factor, which is involved in the maturation of specific proteins in the endoplasmic reticulum, and may be required for maturation and transport of active lipoprotein lipase through the secretory pathway

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LMF1 pfam06762
Lipase maturation factor; This family of transmembrane proteins includes the lipase maturation ...
 1-408 3.97e-165

Lipase maturation factor; This family of transmembrane proteins includes the lipase maturation factor, LMF1. Lipoprotein lipase and hepatic lipase require LMF1 to fold into their active states. It acts as a chaperone required for maturation and transport of active lipoprotein lipase (LPL), through the secretory pathway.


:

Pssm-ID: 462004  Cd Length: 419  Bit Score: 474.52  E-value: 3.97e-165
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2429714623   1 MFASGVVKLTSRCPTWWGLTALTYHYETQCLPTPAAWFAHHLPVWLHKLSVVATFLIEIAVPPLFFAPIRRLRLTAFYAQ 80
Cdd:pfam06762  49 MFGAGLVKLRSDCPTWWDLTALDYHYETQPLPTPLSWYAHQLPSWFHKLETLGNHVVELVVPFLFFAPIRRLRIVAFFIQ 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2429714623  81 ALLQVLIIITGNYNFFNLLTLVLTTALLDDRHLSAEPGlrchKKMPTSWPKALLTALSLLLELTVYGLLAYGTVYYFGLE 160
Cdd:pfam06762 129 VLLQLLIILTGNYGFLNLLTIVLSLSLLDDAFLYFWTP----ESRKKPPRTRLLSVIETLLSLLVYGLLIYGTVSLFGLK 204

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2429714623 161 VDWQQhiilskttftfhqfsQWLKTVTLPTVWLGTASLAWELLVVLWRwiqvqgwSRKFSAGIQLSVLGTATVALFLISL 240
Cdd:pfam06762 205 ISENG---------------TFLRRVTLPSIVLGLVSLLSVPVCALLR-------SNKLIQSIQLAIVTLAAVLLFALSL 262

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2429714623 241 VPYSyvepgthgrLWTGAHRLFGSVEHLQLANSYGLFRRMTgvGGRPEVVLEGSYDG-QHWTEIEFMYKPGNVSRPPPFL 319
Cdd:pfam06762 263 VPFS---------VRNLLSRMNASFNPLHLVNSYGLFGSMT--GGRPEVVIEGSNDGeGPWKEYEFKYKPGDVNRRPPFV 331

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2429714623 320 TPHQPRLDWQMWFAALGPHTHSPWFTGLVLRLLQGKEPVIRLVQShvanYPFHERPPTYLRAQRYKYWFSKPGDQSR--- 396
Cdd:pfam06762 332 APYHPRLDWQMWFAALGTYQQNPWFLSLLYRLLQNDPEVLGLLDH----NPFPDKPPKYVRAELYRYRFTTPGERRAtga 407

                         410
                  ....*....|..
gi 2429714623 397 WWHRQWVEEFFP 408
Cdd:pfam06762 408 WWKRERVGEYFP 419
 
Name Accession Description Interval E-value
LMF1 pfam06762
Lipase maturation factor; This family of transmembrane proteins includes the lipase maturation ...
 1-408 3.97e-165

Lipase maturation factor; This family of transmembrane proteins includes the lipase maturation factor, LMF1. Lipoprotein lipase and hepatic lipase require LMF1 to fold into their active states. It acts as a chaperone required for maturation and transport of active lipoprotein lipase (LPL), through the secretory pathway.


Pssm-ID: 462004  Cd Length: 419  Bit Score: 474.52  E-value: 3.97e-165
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2429714623   1 MFASGVVKLTSRCPTWWGLTALTYHYETQCLPTPAAWFAHHLPVWLHKLSVVATFLIEIAVPPLFFAPIRRLRLTAFYAQ 80
Cdd:pfam06762  49 MFGAGLVKLRSDCPTWWDLTALDYHYETQPLPTPLSWYAHQLPSWFHKLETLGNHVVELVVPFLFFAPIRRLRIVAFFIQ 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2429714623  81 ALLQVLIIITGNYNFFNLLTLVLTTALLDDRHLSAEPGlrchKKMPTSWPKALLTALSLLLELTVYGLLAYGTVYYFGLE 160
Cdd:pfam06762 129 VLLQLLIILTGNYGFLNLLTIVLSLSLLDDAFLYFWTP----ESRKKPPRTRLLSVIETLLSLLVYGLLIYGTVSLFGLK 204

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2429714623 161 VDWQQhiilskttftfhqfsQWLKTVTLPTVWLGTASLAWELLVVLWRwiqvqgwSRKFSAGIQLSVLGTATVALFLISL 240
Cdd:pfam06762 205 ISENG---------------TFLRRVTLPSIVLGLVSLLSVPVCALLR-------SNKLIQSIQLAIVTLAAVLLFALSL 262

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2429714623 241 VPYSyvepgthgrLWTGAHRLFGSVEHLQLANSYGLFRRMTgvGGRPEVVLEGSYDG-QHWTEIEFMYKPGNVSRPPPFL 319
Cdd:pfam06762 263 VPFS---------VRNLLSRMNASFNPLHLVNSYGLFGSMT--GGRPEVVIEGSNDGeGPWKEYEFKYKPGDVNRRPPFV 331

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2429714623 320 TPHQPRLDWQMWFAALGPHTHSPWFTGLVLRLLQGKEPVIRLVQShvanYPFHERPPTYLRAQRYKYWFSKPGDQSR--- 396
Cdd:pfam06762 332 APYHPRLDWQMWFAALGTYQQNPWFLSLLYRLLQNDPEVLGLLDH----NPFPDKPPKYVRAELYRYRFTTPGERRAtga 407

                         410
                  ....*....|..
gi 2429714623 397 WWHRQWVEEFFP 408
Cdd:pfam06762 408 WWKRERVGEYFP 419
 
Name Accession Description Interval E-value
LMF1 pfam06762
Lipase maturation factor; This family of transmembrane proteins includes the lipase maturation ...
 1-408 3.97e-165

Lipase maturation factor; This family of transmembrane proteins includes the lipase maturation factor, LMF1. Lipoprotein lipase and hepatic lipase require LMF1 to fold into their active states. It acts as a chaperone required for maturation and transport of active lipoprotein lipase (LPL), through the secretory pathway.


Pssm-ID: 462004  Cd Length: 419  Bit Score: 474.52  E-value: 3.97e-165
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2429714623   1 MFASGVVKLTSRCPTWWGLTALTYHYETQCLPTPAAWFAHHLPVWLHKLSVVATFLIEIAVPPLFFAPIRRLRLTAFYAQ 80
Cdd:pfam06762  49 MFGAGLVKLRSDCPTWWDLTALDYHYETQPLPTPLSWYAHQLPSWFHKLETLGNHVVELVVPFLFFAPIRRLRIVAFFIQ 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2429714623  81 ALLQVLIIITGNYNFFNLLTLVLTTALLDDRHLSAEPGlrchKKMPTSWPKALLTALSLLLELTVYGLLAYGTVYYFGLE 160
Cdd:pfam06762 129 VLLQLLIILTGNYGFLNLLTIVLSLSLLDDAFLYFWTP----ESRKKPPRTRLLSVIETLLSLLVYGLLIYGTVSLFGLK 204

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2429714623 161 VDWQQhiilskttftfhqfsQWLKTVTLPTVWLGTASLAWELLVVLWRwiqvqgwSRKFSAGIQLSVLGTATVALFLISL 240
Cdd:pfam06762 205 ISENG---------------TFLRRVTLPSIVLGLVSLLSVPVCALLR-------SNKLIQSIQLAIVTLAAVLLFALSL 262

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2429714623 241 VPYSyvepgthgrLWTGAHRLFGSVEHLQLANSYGLFRRMTgvGGRPEVVLEGSYDG-QHWTEIEFMYKPGNVSRPPPFL 319
Cdd:pfam06762 263 VPFS---------VRNLLSRMNASFNPLHLVNSYGLFGSMT--GGRPEVVIEGSNDGeGPWKEYEFKYKPGDVNRRPPFV 331

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2429714623 320 TPHQPRLDWQMWFAALGPHTHSPWFTGLVLRLLQGKEPVIRLVQShvanYPFHERPPTYLRAQRYKYWFSKPGDQSR--- 396
Cdd:pfam06762 332 APYHPRLDWQMWFAALGTYQQNPWFLSLLYRLLQNDPEVLGLLDH----NPFPDKPPKYVRAELYRYRFTTPGERRAtga 407

                         410
                  ....*....|..
gi 2429714623 397 WWHRQWVEEFFP 408
Cdd:pfam06762 408 WWKRERVGEYFP 419
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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