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Conserved domains on  [gi|2330743721|ref|NP_001401263|]
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transmembrane protein 132E precursor [Rattus norvegicus]

Protein Classification

transmembrane protein 132( domain architecture ID 12174329)

transmembrane protein 132 (TMEM132) such as Rattus norvegicus TMEM132D, also called mature oligodendrocytes transmembrane protein (MOLT), that may serve as a cell-surface marker for oligodendrocyte differentiation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TMEM132 pfam16070
Transmembrane protein family 132; This presumed domain is found in members of the TMEM132 ...
 449-795 1.51e-169

Transmembrane protein family 132; This presumed domain is found in members of the TMEM132 family. TMEM132A may be involved in embryonic and postnatal brain development. TMEM132D may be a marker for oligodendrocyte differentiation.


:

Pssm-ID: 465003  Cd Length: 344  Bit Score: 501.05  E-value: 1.51e-169
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2330743721  449 EIINTAILTGRTVAIPVKVIAIEVTGVVLDVSDLVECQSHREDIIKVSSSCDYVFVSGKESRGSMNARVTFRYDVLSAPL 528
Cdd:pfam16070    1 EILNTAILTGRTVAVPVKVVAVEADGTVTDVTESVSCSSTDEDVLKVSSSCDSVYVNGKESRGSSNASVNFTYGTLSAQL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2330743721  529 EMTVWVPKLPLHIELSDARLSQVKGWRVPILPDRRSARESEDEEEEEEerrqSANRGCTLQYQHATLQVFTQFHTTSSEg 608
Cdd:pfam16070   81 EFTVWVPRLPLEIEVSDTELSQIKGWRVPIGSNKRRPARDSEDEEEDD----RKGRGCRLQYQHATVRVLARFVAEDAD- 155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2330743721  609 TEQVVTMLGPDWLVEVTDLVSDFMRVGDPRVAHLVDSNTLAGLEPGTTPFKVVSPLTEAVLGETLLTVTEEKVSITQLQA 688
Cdd:pfam16070  156 TGQVSYLLGSDWQVDVTDLVADFLRVEDPRVARLQDGRVLQGREPGTTTVQVLSPLSDSVLGEKTITVLDDKVTITDLGV 235

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2330743721  689 QVVASLTLSLRPSPGSSHTILATTAAQPTLSSVKQEALLSLWLSYSDGTTAPLSLYSPRDYGLLVNSLDERVATVTQDKA 768
Cdd:pfam16070  236 QLVSGLSLSLQPSPGSNRAIVATTTAQETLTAPKQEALLSAWLQFSDGSVTPLDLYDPSDYNLSVTSLDEAVVAVSQDPA 315

                          330       340
                   ....*....|....*....|....*....
gi 2330743721  769 --FPLLVAEAEGAGDLLRAELTISESCQK 795
Cdd:pfam16070  316 srWPVVVAEGEGQGPLVRVELTISEACQK 344
TMEM132D_N pfam15705
Mature oligodendrocyte transmembrane protein, TMEM132D, N-term; TMEM132D_N is the N-terminal ...
 45-174 1.42e-61

Mature oligodendrocyte transmembrane protein, TMEM132D, N-term; TMEM132D_N is the N-terminal family of chordate proteins implicated in panic disorder. TMEM132D is a single-pass transmembrane protein that is highly expressed in the cortical regions of the human and mouse brain. The function is still unknown. It may act as a cell-surface marker for oligodendrocyte differentiation. Additionally, as it may be most strongly expressed in neurons and it colocalizes with actin filaments TMEM132D may be implicated in neuronal sprouting and connectivity in brain regions important for anxiety-related behaviour.


:

Pssm-ID: 464813 [Multi-domain]  Cd Length: 129  Bit Score: 205.53  E-value: 1.42e-61
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2330743721   45 VSYRLSHTRLAFFLKEARPPTPTamNGSLQ-RSEPFVVFQTKELPVLNVSLGPFSTSQVVARELLQPSSTLDIPERLTVN 123
Cdd:pfam15705    1 VSYQLSNADSAFFLKEANQDLMR--NSSLQsRSESFFIYQARQPPVLNASYGPFSVEQVVPLELLLPSSPLGSPNKFTFN 78

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2330743721  124 WKVRAFIVRARVPASQPVAQVLFYVAGRDWDDFGVTERLPCVRLHAFRDAR 174
Cdd:pfam15705   79 WKLRAHILDSRVYSSRPKVQVLFYIAGRDWDDYDPSERLPCVRLFAFRETR 129
TMEM132D_C pfam15706
Mature oligodendrocyte transmembrane protein, TMEM132D, C-term; TMEM132D_C is the C-terminal ...
 875-940 8.67e-37

Mature oligodendrocyte transmembrane protein, TMEM132D, C-term; TMEM132D_C is the C-terminal family of chordate proteins implicated in panic disorder. TMEM132D is a single-pass transmembrane protein that is highly expressed in the cortical regions of the human and mouse brain. The function is still unknown. It may act as a cell-surface marker for oligodendrocyte differentiation. Additionally, as it may be most strongly expressed in neurons and it colocalizes with actin filaments TMEM132D may be implicated in neuronal sprouting and connectivity in brain regions important for anxiety-related behaviour.


:

Pssm-ID: 464814  Cd Length: 84  Bit Score: 133.19  E-value: 8.67e-37
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2330743721  875 GFLQMPRGLTDLEIGMYALLGVFCLAILVFLINCIVFVLRYRHKRIPPEGQTSMDHSHHWVFLGNG 940
Cdd:pfam15706   19 DLVQAFRGLTDLEIGMYALLGVFCLAILVFLINCVVYALKFRHKQVPVEGQGPVPHSHDWVWLGRE 84
 
Name Accession Description Interval E-value
TMEM132 pfam16070
Transmembrane protein family 132; This presumed domain is found in members of the TMEM132 ...
 449-795 1.51e-169

Transmembrane protein family 132; This presumed domain is found in members of the TMEM132 family. TMEM132A may be involved in embryonic and postnatal brain development. TMEM132D may be a marker for oligodendrocyte differentiation.


Pssm-ID: 465003  Cd Length: 344  Bit Score: 501.05  E-value: 1.51e-169
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2330743721  449 EIINTAILTGRTVAIPVKVIAIEVTGVVLDVSDLVECQSHREDIIKVSSSCDYVFVSGKESRGSMNARVTFRYDVLSAPL 528
Cdd:pfam16070    1 EILNTAILTGRTVAVPVKVVAVEADGTVTDVTESVSCSSTDEDVLKVSSSCDSVYVNGKESRGSSNASVNFTYGTLSAQL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2330743721  529 EMTVWVPKLPLHIELSDARLSQVKGWRVPILPDRRSARESEDEEEEEEerrqSANRGCTLQYQHATLQVFTQFHTTSSEg 608
Cdd:pfam16070   81 EFTVWVPRLPLEIEVSDTELSQIKGWRVPIGSNKRRPARDSEDEEEDD----RKGRGCRLQYQHATVRVLARFVAEDAD- 155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2330743721  609 TEQVVTMLGPDWLVEVTDLVSDFMRVGDPRVAHLVDSNTLAGLEPGTTPFKVVSPLTEAVLGETLLTVTEEKVSITQLQA 688
Cdd:pfam16070  156 TGQVSYLLGSDWQVDVTDLVADFLRVEDPRVARLQDGRVLQGREPGTTTVQVLSPLSDSVLGEKTITVLDDKVTITDLGV 235

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2330743721  689 QVVASLTLSLRPSPGSSHTILATTAAQPTLSSVKQEALLSLWLSYSDGTTAPLSLYSPRDYGLLVNSLDERVATVTQDKA 768
Cdd:pfam16070  236 QLVSGLSLSLQPSPGSNRAIVATTTAQETLTAPKQEALLSAWLQFSDGSVTPLDLYDPSDYNLSVTSLDEAVVAVSQDPA 315

                          330       340
                   ....*....|....*....|....*....
gi 2330743721  769 --FPLLVAEAEGAGDLLRAELTISESCQK 795
Cdd:pfam16070  316 srWPVVVAEGEGQGPLVRVELTISEACQK 344
TMEM132D_N pfam15705
Mature oligodendrocyte transmembrane protein, TMEM132D, N-term; TMEM132D_N is the N-terminal ...
 45-174 1.42e-61

Mature oligodendrocyte transmembrane protein, TMEM132D, N-term; TMEM132D_N is the N-terminal family of chordate proteins implicated in panic disorder. TMEM132D is a single-pass transmembrane protein that is highly expressed in the cortical regions of the human and mouse brain. The function is still unknown. It may act as a cell-surface marker for oligodendrocyte differentiation. Additionally, as it may be most strongly expressed in neurons and it colocalizes with actin filaments TMEM132D may be implicated in neuronal sprouting and connectivity in brain regions important for anxiety-related behaviour.


Pssm-ID: 464813 [Multi-domain]  Cd Length: 129  Bit Score: 205.53  E-value: 1.42e-61
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2330743721   45 VSYRLSHTRLAFFLKEARPPTPTamNGSLQ-RSEPFVVFQTKELPVLNVSLGPFSTSQVVARELLQPSSTLDIPERLTVN 123
Cdd:pfam15705    1 VSYQLSNADSAFFLKEANQDLMR--NSSLQsRSESFFIYQARQPPVLNASYGPFSVEQVVPLELLLPSSPLGSPNKFTFN 78

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2330743721  124 WKVRAFIVRARVPASQPVAQVLFYVAGRDWDDFGVTERLPCVRLHAFRDAR 174
Cdd:pfam15705   79 WKLRAHILDSRVYSSRPKVQVLFYIAGRDWDDYDPSERLPCVRLFAFRETR 129
TMEM132D_C pfam15706
Mature oligodendrocyte transmembrane protein, TMEM132D, C-term; TMEM132D_C is the C-terminal ...
 875-940 8.67e-37

Mature oligodendrocyte transmembrane protein, TMEM132D, C-term; TMEM132D_C is the C-terminal family of chordate proteins implicated in panic disorder. TMEM132D is a single-pass transmembrane protein that is highly expressed in the cortical regions of the human and mouse brain. The function is still unknown. It may act as a cell-surface marker for oligodendrocyte differentiation. Additionally, as it may be most strongly expressed in neurons and it colocalizes with actin filaments TMEM132D may be implicated in neuronal sprouting and connectivity in brain regions important for anxiety-related behaviour.


Pssm-ID: 464814  Cd Length: 84  Bit Score: 133.19  E-value: 8.67e-37
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2330743721  875 GFLQMPRGLTDLEIGMYALLGVFCLAILVFLINCIVFVLRYRHKRIPPEGQTSMDHSHHWVFLGNG 940
Cdd:pfam15706   19 DLVQAFRGLTDLEIGMYALLGVFCLAILVFLINCVVYALKFRHKQVPVEGQGPVPHSHDWVWLGRE 84
 
Name Accession Description Interval E-value
TMEM132 pfam16070
Transmembrane protein family 132; This presumed domain is found in members of the TMEM132 ...
 449-795 1.51e-169

Transmembrane protein family 132; This presumed domain is found in members of the TMEM132 family. TMEM132A may be involved in embryonic and postnatal brain development. TMEM132D may be a marker for oligodendrocyte differentiation.


Pssm-ID: 465003  Cd Length: 344  Bit Score: 501.05  E-value: 1.51e-169
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2330743721  449 EIINTAILTGRTVAIPVKVIAIEVTGVVLDVSDLVECQSHREDIIKVSSSCDYVFVSGKESRGSMNARVTFRYDVLSAPL 528
Cdd:pfam16070    1 EILNTAILTGRTVAVPVKVVAVEADGTVTDVTESVSCSSTDEDVLKVSSSCDSVYVNGKESRGSSNASVNFTYGTLSAQL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2330743721  529 EMTVWVPKLPLHIELSDARLSQVKGWRVPILPDRRSARESEDEEEEEEerrqSANRGCTLQYQHATLQVFTQFHTTSSEg 608
Cdd:pfam16070   81 EFTVWVPRLPLEIEVSDTELSQIKGWRVPIGSNKRRPARDSEDEEEDD----RKGRGCRLQYQHATVRVLARFVAEDAD- 155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2330743721  609 TEQVVTMLGPDWLVEVTDLVSDFMRVGDPRVAHLVDSNTLAGLEPGTTPFKVVSPLTEAVLGETLLTVTEEKVSITQLQA 688
Cdd:pfam16070  156 TGQVSYLLGSDWQVDVTDLVADFLRVEDPRVARLQDGRVLQGREPGTTTVQVLSPLSDSVLGEKTITVLDDKVTITDLGV 235

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2330743721  689 QVVASLTLSLRPSPGSSHTILATTAAQPTLSSVKQEALLSLWLSYSDGTTAPLSLYSPRDYGLLVNSLDERVATVTQDKA 768
Cdd:pfam16070  236 QLVSGLSLSLQPSPGSNRAIVATTTAQETLTAPKQEALLSAWLQFSDGSVTPLDLYDPSDYNLSVTSLDEAVVAVSQDPA 315

                          330       340
                   ....*....|....*....|....*....
gi 2330743721  769 --FPLLVAEAEGAGDLLRAELTISESCQK 795
Cdd:pfam16070  316 srWPVVVAEGEGQGPLVRVELTISEACQK 344
TMEM132D_N pfam15705
Mature oligodendrocyte transmembrane protein, TMEM132D, N-term; TMEM132D_N is the N-terminal ...
 45-174 1.42e-61

Mature oligodendrocyte transmembrane protein, TMEM132D, N-term; TMEM132D_N is the N-terminal family of chordate proteins implicated in panic disorder. TMEM132D is a single-pass transmembrane protein that is highly expressed in the cortical regions of the human and mouse brain. The function is still unknown. It may act as a cell-surface marker for oligodendrocyte differentiation. Additionally, as it may be most strongly expressed in neurons and it colocalizes with actin filaments TMEM132D may be implicated in neuronal sprouting and connectivity in brain regions important for anxiety-related behaviour.


Pssm-ID: 464813 [Multi-domain]  Cd Length: 129  Bit Score: 205.53  E-value: 1.42e-61
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2330743721   45 VSYRLSHTRLAFFLKEARPPTPTamNGSLQ-RSEPFVVFQTKELPVLNVSLGPFSTSQVVARELLQPSSTLDIPERLTVN 123
Cdd:pfam15705    1 VSYQLSNADSAFFLKEANQDLMR--NSSLQsRSESFFIYQARQPPVLNASYGPFSVEQVVPLELLLPSSPLGSPNKFTFN 78

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2330743721  124 WKVRAFIVRARVPASQPVAQVLFYVAGRDWDDFGVTERLPCVRLHAFRDAR 174
Cdd:pfam15705   79 WKLRAHILDSRVYSSRPKVQVLFYIAGRDWDDYDPSERLPCVRLFAFRETR 129
TMEM132D_C pfam15706
Mature oligodendrocyte transmembrane protein, TMEM132D, C-term; TMEM132D_C is the C-terminal ...
 875-940 8.67e-37

Mature oligodendrocyte transmembrane protein, TMEM132D, C-term; TMEM132D_C is the C-terminal family of chordate proteins implicated in panic disorder. TMEM132D is a single-pass transmembrane protein that is highly expressed in the cortical regions of the human and mouse brain. The function is still unknown. It may act as a cell-surface marker for oligodendrocyte differentiation. Additionally, as it may be most strongly expressed in neurons and it colocalizes with actin filaments TMEM132D may be implicated in neuronal sprouting and connectivity in brain regions important for anxiety-related behaviour.


Pssm-ID: 464814  Cd Length: 84  Bit Score: 133.19  E-value: 8.67e-37
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2330743721  875 GFLQMPRGLTDLEIGMYALLGVFCLAILVFLINCIVFVLRYRHKRIPPEGQTSMDHSHHWVFLGNG 940
Cdd:pfam15706   19 DLVQAFRGLTDLEIGMYALLGVFCLAILVFLINCVVYALKFRHKQVPVEGQGPVPHSHDWVWLGRE 84
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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