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Conserved domains on  [gi|2330050962|ref|NP_001401229|]
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adhesion G protein-coupled receptor E5 isoform 9 precursor [Mus musculus]

Protein Classification

EGF_CA domain-containing protein( domain architecture ID 10541502)

EGF_CA domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
EGF_CA pfam07645
Calcium-binding EGF domain;
165-196 4.86e-12

Calcium-binding EGF domain;


:

Pssm-ID: 429571  Cd Length: 32  Bit Score: 60.33  E-value: 4.86e-12
                          10        20        30
                  ....*....|....*....|....*....|..
gi 2330050962 165 DVNECISGQNHCHQSTHCINKLGGYSCICRQG 196
Cdd:pfam07645   1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32
EGF_CA pfam07645
Calcium-binding EGF domain;
214-245 6.47e-11

Calcium-binding EGF domain;


:

Pssm-ID: 429571  Cd Length: 32  Bit Score: 56.86  E-value: 6.47e-11
                          10        20        30
                  ....*....|....*....|....*....|..
gi 2330050962 214 DVDECSSGQHQCHNSTVCKNTVGSYKCHCRPG 245
Cdd:pfam07645   1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32
EGF_CA pfam07645
Calcium-binding EGF domain;
69-97 1.21e-05

Calcium-binding EGF domain;


:

Pssm-ID: 429571  Cd Length: 32  Bit Score: 42.22  E-value: 1.21e-05
                          10        20
                  ....*....|....*....|....*....
gi 2330050962  69 DINECLLPGFSCGDFAMCKNSEGSYTCVC 97
Cdd:pfam07645   1 DVDECATGTHNCPANTVCVNTIGSFECRC 29
 
Name Accession Description Interval E-value
EGF_CA pfam07645
Calcium-binding EGF domain;
165-196 4.86e-12

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 60.33  E-value: 4.86e-12
                          10        20        30
                  ....*....|....*....|....*....|..
gi 2330050962 165 DVNECISGQNHCHQSTHCINKLGGYSCICRQG 196
Cdd:pfam07645   1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32
EGF_CA pfam07645
Calcium-binding EGF domain;
214-245 6.47e-11

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 56.86  E-value: 6.47e-11
                          10        20        30
                  ....*....|....*....|....*....|..
gi 2330050962 214 DVDECSSGQHQCHNSTVCKNTVGSYKCHCRPG 245
Cdd:pfam07645   1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
214-246 3.06e-09

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 52.25  E-value: 3.06e-09
                           10        20        30
                   ....*....|....*....|....*....|...
gi 2330050962  214 DVDECSSGqHQCHNSTVCKNTVGSYKCHCRPGW 246
Cdd:smart00179   1 DIDECASG-NPCQNGGTCVNTVGSYRCECPPGY 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 214-246 1.05e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 50.71  E-value: 1.05e-08
                          10        20        30
                  ....*....|....*....|....*....|...
gi 2330050962 214 DVDECSSGqHQCHNSTVCKNTVGSYKCHCRPGW 246
Cdd:cd00054     1 DIDECASG-NPCQNGGTCVNTVGSYRCSCPPGY 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
165-197 2.85e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.16  E-value: 2.85e-06
                           10        20        30
                   ....*....|....*....|....*....|...
gi 2330050962  165 DVNECISGqNHCHQSTHCINKLGGYSCICRQGW 197
Cdd:smart00179   1 DIDECASG-NPCQNGGTCVNTVGSYRCECPPGY 32
EGF_CA pfam07645
Calcium-binding EGF domain;
69-97 1.21e-05

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 42.22  E-value: 1.21e-05
                          10        20
                  ....*....|....*....|....*....
gi 2330050962  69 DINECLLPGFSCGDFAMCKNSEGSYTCVC 97
Cdd:pfam07645   1 DVDECATGTHNCPANTVCVNTIGSFECRC 29
EGF_CA smart00179
Calcium-binding EGF-like domain;
69-101 1.50e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.85  E-value: 1.50e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 2330050962   69 DINECLLPGfSCGDFAMCKNSEGSYTCVCNLGY 101
Cdd:smart00179   1 DIDECASGN-PCQNGGTCVNTVGSYRCECPPGY 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 69-103 2.71e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.08  E-value: 2.71e-05
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 2330050962  69 DINECLLPGfSCGDFAMCKNSEGSYTCVCNLGYKL 103
Cdd:cd00054     1 DIDECASGN-PCQNGGTCVNTVGSYRCSCPPGYTG 34
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 165-197 2.77e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.08  E-value: 2.77e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 2330050962 165 DVNECISGqNHCHQSTHCINKLGGYSCICRQGW 197
Cdd:cd00054     1 DIDECASG-NPCQNGGTCVNTVGSYRCSCPPGY 32
 
Name Accession Description Interval E-value
EGF_CA pfam07645
Calcium-binding EGF domain;
165-196 4.86e-12

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 60.33  E-value: 4.86e-12
                          10        20        30
                  ....*....|....*....|....*....|..
gi 2330050962 165 DVNECISGQNHCHQSTHCINKLGGYSCICRQG 196
Cdd:pfam07645   1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32
EGF_CA pfam07645
Calcium-binding EGF domain;
214-245 6.47e-11

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 56.86  E-value: 6.47e-11
                          10        20        30
                  ....*....|....*....|....*....|..
gi 2330050962 214 DVDECSSGQHQCHNSTVCKNTVGSYKCHCRPG 245
Cdd:pfam07645   1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
214-246 3.06e-09

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 52.25  E-value: 3.06e-09
                           10        20        30
                   ....*....|....*....|....*....|...
gi 2330050962  214 DVDECSSGqHQCHNSTVCKNTVGSYKCHCRPGW 246
Cdd:smart00179   1 DIDECASG-NPCQNGGTCVNTVGSYRCECPPGY 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 214-246 1.05e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 50.71  E-value: 1.05e-08
                          10        20        30
                  ....*....|....*....|....*....|...
gi 2330050962 214 DVDECSSGqHQCHNSTVCKNTVGSYKCHCRPGW 246
Cdd:cd00054     1 DIDECASG-NPCQNGGTCVNTVGSYRCSCPPGY 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
165-197 2.85e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.16  E-value: 2.85e-06
                           10        20        30
                   ....*....|....*....|....*....|...
gi 2330050962  165 DVNECISGqNHCHQSTHCINKLGGYSCICRQGW 197
Cdd:smart00179   1 DIDECASG-NPCQNGGTCVNTVGSYRCECPPGY 32
EGF_CA pfam07645
Calcium-binding EGF domain;
69-97 1.21e-05

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 42.22  E-value: 1.21e-05
                          10        20
                  ....*....|....*....|....*....
gi 2330050962  69 DINECLLPGFSCGDFAMCKNSEGSYTCVC 97
Cdd:pfam07645   1 DVDECATGTHNCPANTVCVNTIGSFECRC 29
EGF_CA smart00179
Calcium-binding EGF-like domain;
69-101 1.50e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.85  E-value: 1.50e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 2330050962   69 DINECLLPGfSCGDFAMCKNSEGSYTCVCNLGY 101
Cdd:smart00179   1 DIDECASGN-PCQNGGTCVNTVGSYRCECPPGY 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 69-103 2.71e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.08  E-value: 2.71e-05
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 2330050962  69 DINECLLPGfSCGDFAMCKNSEGSYTCVCNLGYKL 103
Cdd:cd00054     1 DIDECASGN-PCQNGGTCVNTVGSYRCSCPPGYTG 34
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 165-197 2.77e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.08  E-value: 2.77e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 2330050962 165 DVNECISGqNHCHQSTHCINKLGGYSCICRQGW 197
Cdd:cd00054     1 DIDECASG-NPCQNGGTCVNTVGSYRCSCPPGY 32
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 218-245 4.04e-05

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 40.66  E-value: 4.04e-05
                          10        20
                  ....*....|....*....|....*...
gi 2330050962 218 CSSGQHQCHNSTVCKNTVGSYKCHCRPG 245
Cdd:pfam12947   1 CSDNNGGCHPNATCTNTGGSFTCTCNDG 28
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 217-246 1.24e-04

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 39.38  E-value: 1.24e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 2330050962 217 ECSSgQHQCHNSTVCKNTVGSYKCHCRPGW 246
Cdd:cd00053     1 ECAA-SNPCSNGGTCVNTPGSYRCVCPPGY 29
hEGF pfam12661
Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six ...
 225-246 1.72e-03

Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six conserved residues disulfide-bonded into the characteriztic 'ababcc' pattern. They are involved in growth and proliferation of cells, in proteins of the Notch/Delta pathway, neurogulin and selectins. hEGFs are also found in mosaic proteins with four-disulfide laminin EGFs such as aggrecan and perlecan. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal Cys residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In hEGFs the C-terminal thiol resides in the beta-turn, resulting in shorter loop-lengths between the Cys residues of disulfide 'c', typically C[8-9]XC. These shorter loop-lengths are also typical of the four-disulfide EGF domains, laminin ad integrin. Tandem hEGF domains have six linking residues between terminal cysteines of adjacent domains. hEGF domains may or may not bind calcium in the linker region. hEGF domains with the consensus motif CXD4X[F,Y]XCXC are hydroxylated exclusively in the Asp residue.


Pssm-ID: 463660  Cd Length: 22  Bit Score: 35.77  E-value: 1.72e-03
                          10        20
                  ....*....|....*....|..
gi 2330050962 225 CHNSTVCKNTVGSYKCHCRPGW 246
Cdd:pfam12661   1 CQNGGTCVDGVNGYKCQCPPGY 22
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 80-102 2.10e-03

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 35.65  E-value: 2.10e-03
                          10        20
                  ....*....|....*....|...
gi 2330050962  80 CGDFAMCKNSEGSYTCVCNLGYK 102
Cdd:pfam12947   8 CHPNATCTNTGGSFTCTCNDGYT 30
EGF smart00181
Epidermal growth factor-like domain;
217-247 2.33e-03

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 35.57  E-value: 2.33e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 2330050962  217 ECSSGqHQCHNSTvCKNTVGSYKCHCRPGWK 247
Cdd:smart00181   1 ECASG-GPCSNGT-CINTPGSYTCSCPPGYT 29
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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