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Conserved domains on  [gi|2324175226|ref|NP_001400346|]
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alpha-tocopherol transfer protein isoform 5 [Homo sapiens]

Protein Classification

SEC14 family lipid-binding protein( domain architecture ID 10661230)

SEC14 family lipid-binding protein contains a lipid-binding domain that is found in secretory proteins and in lipid regulated proteins

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
CRAL_TRIO_N smart01100
CRAL/TRIO, N-terminal domain;
40-67 5.15e-07

CRAL/TRIO, N-terminal domain;


:

Pssm-ID: 215024  Cd Length: 48  Bit Score: 43.31  E-value: 5.15e-07
                           10        20
                   ....*....|....*....|....*...
gi 2324175226   40 VPLAPLPLTDSFLLRFLRARDFDLDLAW 67
Cdd:smart01100  15 PDLLPPRLDDAFLLRFLRARKFDVEKAK 42
SEC14 super family cl49645
Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p); Domain ...
64-95 1.09e-03

Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p); Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p) and in RhoGAPs, RhoGEFs and the RasGAP, neurofibromin (NF1). Lipid-binding domain. The SEC14 domain of Dbl is known to associate with G protein beta/gamma subunits.


The actual alignment was detected with superfamily member smart00516:

Pssm-ID: 214706 [Multi-domain]  Cd Length: 158  Bit Score: 36.51  E-value: 1.09e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 2324175226   64 DLAWRIHMHGNNYKQSLLQHF-PDILPLEYGGE 95
Cdd:smart00516 124 KTREKIRFVGNDSKEELLEYIdKEQLPEELGGT 156
 
Name Accession Description Interval E-value
CRAL_TRIO_N smart01100
CRAL/TRIO, N-terminal domain;
40-67 5.15e-07

CRAL/TRIO, N-terminal domain;


Pssm-ID: 215024  Cd Length: 48  Bit Score: 43.31  E-value: 5.15e-07
                           10        20
                   ....*....|....*....|....*...
gi 2324175226   40 VPLAPLPLTDSFLLRFLRARDFDLDLAW 67
Cdd:smart01100  15 PDLLPPRLDDAFLLRFLRARKFDVEKAK 42
CRAL_TRIO_N pfam03765
CRAL/TRIO, N-terminal domain; This all-alpha domain is found to the N-terminus of pfam00650.
49-67 1.08e-04

CRAL/TRIO, N-terminal domain; This all-alpha domain is found to the N-terminus of pfam00650.


Pssm-ID: 461043  Cd Length: 53  Bit Score: 37.25  E-value: 1.08e-04
                          10
                  ....*....|....*....
gi 2324175226  49 DSFLLRFLRARDFDLDLAW 67
Cdd:pfam03765  30 DVCLLRFLRARKWDVEKAI 48
SEC14 smart00516
Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p); Domain ...
64-95 1.09e-03

Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p); Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p) and in RhoGAPs, RhoGEFs and the RasGAP, neurofibromin (NF1). Lipid-binding domain. The SEC14 domain of Dbl is known to associate with G protein beta/gamma subunits.


Pssm-ID: 214706 [Multi-domain]  Cd Length: 158  Bit Score: 36.51  E-value: 1.09e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 2324175226   64 DLAWRIHMHGNNYKQSLLQHF-PDILPLEYGGE 95
Cdd:smart00516 124 KTREKIRFVGNDSKEELLEYIdKEQLPEELGGT 156
CRAL_TRIO pfam00650
CRAL/TRIO domain;
68-94 4.85e-03

CRAL/TRIO domain;


Pssm-ID: 459890 [Multi-domain]  Cd Length: 151  Bit Score: 34.92  E-value: 4.85e-03
                          10        20
                  ....*....|....*....|....*...
gi 2324175226  68 RIHMHGNNYKQSLLQHFP-DILPLEYGG 94
Cdd:pfam00650 124 KIVFLKNSNEEELEKYIPpEQLPKEYGG 151
 
Name Accession Description Interval E-value
CRAL_TRIO_N smart01100
CRAL/TRIO, N-terminal domain;
40-67 5.15e-07

CRAL/TRIO, N-terminal domain;


Pssm-ID: 215024  Cd Length: 48  Bit Score: 43.31  E-value: 5.15e-07
                           10        20
                   ....*....|....*....|....*...
gi 2324175226   40 VPLAPLPLTDSFLLRFLRARDFDLDLAW 67
Cdd:smart01100  15 PDLLPPRLDDAFLLRFLRARKFDVEKAK 42
CRAL_TRIO_N pfam03765
CRAL/TRIO, N-terminal domain; This all-alpha domain is found to the N-terminus of pfam00650.
49-67 1.08e-04

CRAL/TRIO, N-terminal domain; This all-alpha domain is found to the N-terminus of pfam00650.


Pssm-ID: 461043  Cd Length: 53  Bit Score: 37.25  E-value: 1.08e-04
                          10
                  ....*....|....*....
gi 2324175226  49 DSFLLRFLRARDFDLDLAW 67
Cdd:pfam03765  30 DVCLLRFLRARKWDVEKAI 48
SEC14 smart00516
Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p); Domain ...
64-95 1.09e-03

Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p); Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p) and in RhoGAPs, RhoGEFs and the RasGAP, neurofibromin (NF1). Lipid-binding domain. The SEC14 domain of Dbl is known to associate with G protein beta/gamma subunits.


Pssm-ID: 214706 [Multi-domain]  Cd Length: 158  Bit Score: 36.51  E-value: 1.09e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 2324175226   64 DLAWRIHMHGNNYKQSLLQHF-PDILPLEYGGE 95
Cdd:smart00516 124 KTREKIRFVGNDSKEELLEYIdKEQLPEELGGT 156
CRAL_TRIO pfam00650
CRAL/TRIO domain;
68-94 4.85e-03

CRAL/TRIO domain;


Pssm-ID: 459890 [Multi-domain]  Cd Length: 151  Bit Score: 34.92  E-value: 4.85e-03
                          10        20
                  ....*....|....*....|....*...
gi 2324175226  68 RIHMHGNNYKQSLLQHFP-DILPLEYGG 94
Cdd:pfam00650 124 KIVFLKNSNEEELEKYIPpEQLPKEYGG 151
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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