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Conserved domains on  [gi|2287254631|ref|NP_001397710|]
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CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform w [Homo sapiens]

Protein Classification

glycosyltransferase family 29 protein( domain architecture ID 10466376)

glycosyltransferase family 29 protein catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds; uses a nucleotide monophosphosugar as the donor instead of a nucleotide diphosphosugar

CATH:  3.90.1480.20
CAZY:  GT29
EC:  2.4.-.-
Gene Ontology:  GO:0006486|GO:0008373
PubMed:  9334165

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
GT29 super family cl45931
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 140-334 1.06e-150

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


The actual alignment was detected with superfamily member cd23981:

Pssm-ID: 480271  Cd Length: 207  Bit Score: 425.11  E-value: 1.06e-150
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287254631 140 RCRRCIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPVKGFEKDVGSKTTLRITYPEGAMQRPEQYERDSLFVLAGFKWQD 219
Cdd:cd23981     1 SCRRCIIVGNGGVLANKSLGSKIDDYDVVVRLNSAPVKGFEKDVGSKTTLRITYPEGAIQKPEQYEKDSLFVLAGFKWQD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287254631 220 FKWLKYIVYKERVSASDGFWKSVATRVPKEPPEIRILNPYFIQEAAFTLIGLPFNNGLMGRGNIPTLGSVAVTMALHGCD 299
Cdd:cd23981    81 FKWLKYIVYKEKVSASDGFWKSVATRVPREPHEIRILNPYFIQEAAFSFIGLPFNNGLMGRGNIPTLGSVAITMALHNCD 160

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 2287254631 300 EVAVAGFGYDMSTPNAPLHYYETVRMAAIKEPRPH 334
Cdd:cd23981   161 EVAVAGFGYDMNTPNAPLHYYETIKMSAIKESWTH 195
 
Name Accession Description Interval E-value
GT29_ST3GAL3 cd23981
beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from ...
 140-334 1.06e-150

beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL3 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,3GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467709  Cd Length: 207  Bit Score: 425.11  E-value: 1.06e-150
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287254631 140 RCRRCIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPVKGFEKDVGSKTTLRITYPEGAMQRPEQYERDSLFVLAGFKWQD 219
Cdd:cd23981     1 SCRRCIIVGNGGVLANKSLGSKIDDYDVVVRLNSAPVKGFEKDVGSKTTLRITYPEGAIQKPEQYEKDSLFVLAGFKWQD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287254631 220 FKWLKYIVYKERVSASDGFWKSVATRVPKEPPEIRILNPYFIQEAAFTLIGLPFNNGLMGRGNIPTLGSVAVTMALHGCD 299
Cdd:cd23981    81 FKWLKYIVYKEKVSASDGFWKSVATRVPREPHEIRILNPYFIQEAAFSFIGLPFNNGLMGRGNIPTLGSVAITMALHNCD 160

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 2287254631 300 EVAVAGFGYDMSTPNAPLHYYETVRMAAIKEPRPH 334
Cdd:cd23981   161 EVAVAGFGYDMNTPNAPLHYYETIKMSAIKESWTH 195
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 100-334 1.09e-77

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 241.36  E-value: 1.09e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287254631 100 KWARIREFVPPFgiKGQDNLIKAILSVTKeyrltpaLDSLRCRRCIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPVKGF 179
Cdd:pfam00777  11 EWIRYSEWWLPF--TVTEELLELLPKVSP-------FDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTKGY 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287254631 180 EKDVGSKTTLRITYPEGAMQR-------PEQYERDSLFVLAGFKWQDFKWLKYIVYKERVSAS---DGFWKSVatRVPKE 249
Cdd:pfam00777  82 EKDVGSKTTLRTMNPESAIDSkygnlgfSHPRDPFVEFVLVPFKGRDLLWLPAFLTKGNVSRSlrvLYTLKEV--KIPVD 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287254631 250 PPEIRILNPYFIQEAAFTLIGLPFNNglmgrGNIPTLGSVAVTMALHGCDEVAVAGFGYDMSTPNAPLHYYETVRMAAIK 329
Cdd:pfam00777 160 PDKVLFLHPDFLRYVANFWLRSHGLK-----GRRPSTGLLMLSLALHLCDEVSLYGFGPFLDSRGNSHHYYDNVLMKKGG 234


                  ....*
gi 2287254631 330 EPRPH 334
Cdd:pfam00777 235 FYGVH 239
 
Name Accession Description Interval E-value
GT29_ST3GAL3 cd23981
beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from ...
 140-334 1.06e-150

beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL3 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,3GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467709  Cd Length: 207  Bit Score: 425.11  E-value: 1.06e-150
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287254631 140 RCRRCIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPVKGFEKDVGSKTTLRITYPEGAMQRPEQYERDSLFVLAGFKWQD 219
Cdd:cd23981     1 SCRRCIIVGNGGVLANKSLGSKIDDYDVVVRLNSAPVKGFEKDVGSKTTLRITYPEGAIQKPEQYEKDSLFVLAGFKWQD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287254631 220 FKWLKYIVYKERVSASDGFWKSVATRVPKEPPEIRILNPYFIQEAAFTLIGLPFNNGLMGRGNIPTLGSVAVTMALHGCD 299
Cdd:cd23981    81 FKWLKYIVYKEKVSASDGFWKSVATRVPREPHEIRILNPYFIQEAAFSFIGLPFNNGLMGRGNIPTLGSVAITMALHNCD 160

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 2287254631 300 EVAVAGFGYDMSTPNAPLHYYETVRMAAIKEPRPH 334
Cdd:cd23981   161 EVAVAGFGYDMNTPNAPLHYYETIKMSAIKESWTH 195
GT29_ST3GAL3_4_5_6 cd23967
beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid ...
 140-330 1.04e-116

beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL3 and 4 utilize bothGalbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates. ST3GAL5 is also known as GM3 ganglioside synthase. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467695  Cd Length: 205  Bit Score: 338.88  E-value: 1.04e-116
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287254631 140 RCRRCIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPVKGFEKDVGSKTTLRITYPEGAMQRPEQYERDSLFVLAGFKWQD 219
Cdd:cd23967     1 SCRRCVVVGNGGVLKGKSLGSVIDKYDVVIRMNDAPVKGYEKDVGSKTTFRMFYPESAFRDPEEYDSDWLLVLVPFKSMD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287254631 220 FKWLKYIVYKERVSASDGFWKSVATRVPKEPPEIRILNPYFIQEAAFTLIGLPFNNglMGRGNIPTLGSVAVTMALHGCD 299
Cdd:cd23967    81 LLWLQAVIKGKKPNGKGGFWKKIATSVPKPPKKIRILNPYILQEAAFDLIGLPMNG--KQGKNVPTTGIIAIVMALHYCD 158

                         170       180       190
                  ....*....|....*....|....*....|.
gi 2287254631 300 EVAVAGFGYDMSTPNAPLHYYETVRMAAIKE 330
Cdd:cd23967   159 EVDIAGFGYDPSDPNAPLHYYDSLTMKAIKR 189
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 141-334 2.34e-80

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467711  Cd Length: 211  Bit Score: 246.57  E-value: 2.34e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287254631 141 CRRCIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPVKGFEKDVGSKTTLRITYPEGAMQRPEQYERDSLFVLAGFKWQDF 220
Cdd:cd23983     2 CRRCVVVGSGGILHGLELGHLLDQFDIVIRLNNAPVQGYSQDVGNKTTIRMTYPEGAPKSEQEYDPTSLFVAVLFKSVDF 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287254631 221 KWLKYIVYKERVSASDG--FWKSVATRVPKEPPEIRILNPYFIQEAAFTLIGL--PFNNGLMGRGNIPTLGSVAVTMALH 296
Cdd:cd23983    82 AWLKAMVKKEPLSFWSRlfFWKEVADSIPLKPSQFRILNPLIIKETALDILQYpePQSRLWGWDKNVPTLGVTAVVLATH 161

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 2287254631 297 GCDEVAVAGFGYDMSTPNAPLHYYETVRMAAIKEPRPH 334
Cdd:cd23983   162 LCDEVSLAGFGYDLSQPHAPLHYYDSVCMAAMNTQTMH 199
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 100-334 1.09e-77

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 241.36  E-value: 1.09e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287254631 100 KWARIREFVPPFgiKGQDNLIKAILSVTKeyrltpaLDSLRCRRCIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPVKGF 179
Cdd:pfam00777  11 EWIRYSEWWLPF--TVTEELLELLPKVSP-------FDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTKGY 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287254631 180 EKDVGSKTTLRITYPEGAMQR-------PEQYERDSLFVLAGFKWQDFKWLKYIVYKERVSAS---DGFWKSVatRVPKE 249
Cdd:pfam00777  82 EKDVGSKTTLRTMNPESAIDSkygnlgfSHPRDPFVEFVLVPFKGRDLLWLPAFLTKGNVSRSlrvLYTLKEV--KIPVD 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287254631 250 PPEIRILNPYFIQEAAFTLIGLPFNNglmgrGNIPTLGSVAVTMALHGCDEVAVAGFGYDMSTPNAPLHYYETVRMAAIK 329
Cdd:pfam00777 160 PDKVLFLHPDFLRYVANFWLRSHGLK-----GRRPSTGLLMLSLALHLCDEVSLYGFGPFLDSRGNSHHYYDNVLMKKGG 234


                  ....*
gi 2287254631 330 EPRPH 334
Cdd:pfam00777 235 FYGVH 239
GT29_ST3GAL6 cd23984
beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from ...
 141-334 5.19e-70

beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467712  Cd Length: 206  Bit Score: 219.62  E-value: 5.19e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287254631 141 CRRCIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPVKGFEKDVGSKTTLRITYPEGAMQRPEQYERDSLFVLAGFKWQDF 220
Cdd:cd23984     2 CKKCVVVGNGGVLRNKSLGKKIDSYDVIIRMNNGPVIGYENDVGKRTTFRLCYPESIFSDPSHYDPNTTVVLIPFKPHDL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287254631 221 KWLKYIVYKERVSASdGFWKSVATRVPKEPPEIRILNPYFIQEAAFTLIGLPFNNGLMGRGNIPTLGSVAVTMALHGCDE 300
Cdd:cd23984    82 RWLLDLLMGKKVSAK-GFWKKPALNLIYKPNQIRILNPFILRIAAYELLHFPKRFPKEKKPKHPTTGIIAITLALHICNE 160

                         170       180       190
                  ....*....|....*....|....*....|....
gi 2287254631 301 VAVAGFGYDMSTPNAPLHYYETVRMAAIKEPRPH 334
Cdd:cd23984   161 VHIAGFKYDFSNLNSTLHYYGNETMSVMTKNEYH 194
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 140-325 3.13e-68

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467710  Cd Length: 204  Bit Score: 214.91  E-value: 3.13e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287254631 140 RCRRCIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPVKGFEKDVGSKTTLRITYPEGAMQRP-EQYERDSLFVLAGFKWQ 218
Cdd:cd23982     1 RCRRCVVVGNGHNLKNSSLGDVIDSYDVVIRLNDAPVRGFEKDVGSKTTIRLFYPESAQFDPgIENDPDTLLVLVPFKPL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287254631 219 DFKWLKYIVYKERVSAsDGFWKSVATRVPKEPPEIRILNPYFIQEAAFTLIGLPfnnGLMGRGNIPTLGSVAVTMALHGC 298
Cdd:cd23982    81 DFYWLYEILSNEKRVR-KGFWKQPPRIWDANPKQIRILNPYYTYVAATKLLQVP---GQRKKKQKPTTGLLAITLALHLC 156

                         170       180
                  ....*....|....*....|....*...
gi 2287254631 299 DEVAVAGFGY-DMSTPNAPLHYYETVRM 325
Cdd:cd23982   157 DEVHIAGFGYpDNGNSNQPIHYYNQITL 184
GT29 cd19952
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 144-327 1.67e-46

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


Pssm-ID: 467690  Cd Length: 193  Bit Score: 158.29  E-value: 1.67e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287254631 144 CIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPVKGFEKDVGSKTTLRITYPEGAMQR---------PEQYERDSLFVLAG 214
Cdd:cd19952     1 CAVVGNSGILLGSEYGKEIDSHDAVFRFNQAPTKGFEKDVGSKTTFRVLNSKWAGFYlrgprcgchPLPLEEEVVLILSR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287254631 215 FKWQDFKWLKYIVYkervsasdgfwksvatRVPKEPPEIRILNPYFIQEAAFTLIGLpfNNGLMGRGNIPTLGSVAVTMA 294
Cdd:cd19952    81 AAAADFKRLKRRKK----------------RHDNAVLLLTDPAPDLLSYVRKRLEKL--GLKSFFGGNAPSSGLLAVLLA 142

                         170       180       190
                  ....*....|....*....|....*....|....
gi 2287254631 295 LHGCDEVAVAGFGYDMS-TPNAPLHYYETVRMAA 327
Cdd:cd19952   143 LQLCDSVDLYGFGVDSGhAPKVPYHYYDLVEAEE 176
GT29_ST3GAL1_2 cd23966
beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from ...
 140-324 2.16e-38

beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL1 and 2 preferentially utilize the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1O-glycans) and on glycolipids as an acceptor substrate, respectively. Members ofthis family belong to glycosyltransferase family 29.


Pssm-ID: 467694  Cd Length: 276  Bit Score: 139.72  E-value: 2.16e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287254631 140 RCRRCIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPVKGFEKDVGSKTTLRITYPEGAM-QRPEQYerdslFVLAGFKWQ 218
Cdd:cd23966    76 RCRRCAVVGNSGNLRGSRYGKLIDSHDFVIRMNKAPTKGFEKDVGSKTTHHFMYPESAVdLDPGVH-----LVLVPFKVL 150

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287254631 219 DFKWLKyivykervSA-SDGFWKSVATRVPK----EPPEIRILNPYFIQEAAFTLIGlpfnnglmGRGNIPTLGSVAVTM 293
Cdd:cd23966   151 DLQWLI--------SAlTTGEITRTYTPVKRfikaDKDKVLVINPAFIKYVHDNWTE--------HHGRYPSTGFLALIF 214

                         170       180       190
                  ....*....|....*....|....*....|.
gi 2287254631 294 ALHGCDEVAVAGFGYDmSTPNAPlHYYETVR 324
Cdd:cd23966   215 ALHICDEVSVFGFGAD-SKGNWH-HYWEKNR 243
GT29_ST6GALNAC1_2 cd23964
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members ...
 91-324 5.24e-38

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 and 2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467692  Cd Length: 292  Bit Score: 138.93  E-value: 5.24e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287254631  91 PMFLDDS---FRKWARIREFVPPFGIKGQD-NLIKAILSVTK----EYRLTPALDSLRCRRCIIVGNGGVLANKSLGSRI 162
Cdd:cd23964    24 KVLLDSEdfnPEEYNRLSHYKLPFGWGGLNrEVVERLLRNLNltssRYMFVLRGGRPRCIRCAVVGNGGILNGSGKGKEI 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287254631 163 DDYDIVVRLNSAPVKGFEKDVGSKTTLRITYPE---GAMQRPEQYERDSLFVLAGFKWQDFKWLKYIVYKERVSASDGFW 239
Cdd:cd23964   104 DAHDYVFRVNHALTKGFEKDVGTKTSFYTFFPEslhNSLLKHVPQDKDTKYLFIPFKIRDYDYLDAVLSGKPVPDGCDKG 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287254631 240 KSV-ATRVPKEPPE-IRILNPYFIQEAaftliglpFNNGL-MGRGNIPTLGSVAVTMALHGCDEVAVAGFGYDmstPNAP 316
Cdd:cd23964   184 KRPpPLFGPKLNATnVRLLHPDFIRYL--------FNRWLnSSTSYRPTTGALMLLTALHTCDQVSVYGFGYD---PRFS 252


                  ....*...
gi 2287254631 317 LHYYETVR 324
Cdd:cd23964   253 LHYYDKTF 260
GT29_ST3GAL1 cd23980
beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from ...
 95-321 4.62e-29

beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL1 preferentially utilizes the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1 O-glycans) as an acceptor substrate. Members of this family belong to glycosyltransferase family29 (GT29).


Pssm-ID: 467708  Cd Length: 280  Bit Score: 114.59  E-value: 4.62e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287254631  95 DDSFRKWARIREFVPPfgiKGQDNLIKAILSVTK-EYRLTPALDSLRCRRCIIVGNGGVLANKSLGSRIDDYDIVVRLNS 173
Cdd:cd23980    37 EDTYKWWLRLQREKKP---KNLNDTIRELFQVVPgNVDPLLEKRLVSCRRCAVVGNSGNLKESYYGPQIDSHDFVLRMNK 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287254631 174 APVKGFEKDVGSKTTLRITYPEGAMQRPEQYErdslFVLAGFKWQDFKWLKYIVYKERVSASdgfWKSVATRVPKEPPEI 253
Cdd:cd23980   114 APTEGFEADVGSKTTHHFVYPESFRELAQNVS----MILVPFKTLDLEWVISATTTGTISHT---YVPVPRKIKVKKEKI 186

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2287254631 254 RILNPYFIQEAaftliglpFNNGLMGRGNIPTLGSVAVTMALHGCDEVAVAGFGYDmSTPNAPlHYYE 321
Cdd:cd23980   187 LIYHPAFIKYV--------FDRWLQGHGRYPSTGILSVIFSLHVCDEVDLYGFGAD-SKGNWH-HYWE 244
GT29_ST3GAL2 cd23979
beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from ...
 137-326 1.21e-24

beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL2 preferentially utilizes the Galbeta1,3GalNAc on glycolipids as an acceptor substrate. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467707  Cd Length: 279  Bit Score: 102.26  E-value: 1.21e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287254631 137 DSLRCRRCIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPVKGFEKDVGSKTTLRITYPEGAMQRPEQYErdslFVLAGFK 216
Cdd:cd23979    76 DPSRCRRCAVVGNSGNLRGSGYGKDIDGHDFIMRMNQAPTVGFEADVGSRTTHHFMYPESAKNLPANVS----FVLVPFK 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287254631 217 WQDFKWLKYIVYKERVSASDGFWKSVaTRVPKEppEIRILNPYFiqeaaFTLIglpFNNGLMGRGNIPTLGSVAVTMALH 296
Cdd:cd23979   152 TLDLLWITSALSTGQIRFTYAPVKQF-LRVDKD--KVQIYNPAF-----FKYI---HDRWTEHHGRYPSTGMLVLFFALH 220

                         170       180       190
                  ....*....|....*....|....*....|
gi 2287254631 297 GCDEVAVAGFGYDmSTPNAPlHYYETVRMA 326
Cdd:cd23979   221 VCDEVNVYGFGAD-SRGNWH-HYWENNRYA 248
GT29_ST6GALNAC1 cd23973
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are ...
 92-322 3.47e-21

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467701  Cd Length: 309  Bit Score: 93.28  E-value: 3.47e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287254631  92 MFLDD---SFRKWARIREFVPPFGIKGQD-NLIKAILSV---TKEYRLTPAL--DSLRCRRCIIVGNGGVLANKSLGSRI 162
Cdd:cd23973    25 LFLDKdhfNMSEWDRLEHFNPPFGFMGLNyTLVKEVVELipkPKEQQLLALSppGGDGCIRCAVVGNGGILNGSKMGQEI 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287254631 163 DDYDIVVRLNSAPVKGFEKDVGSKT------------TLRITYPEGAMQRPEQYERDSLFVLAGFKwqDFKWLKYIVYKE 230
Cdd:cd23973   105 DSHDYVFRVNGAVIKGYEEDVGTRTsfyvhtahsitsSLMILQKRGFKNIPQDKDIKYILFPEGPR--DYQWLEALLKNK 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287254631 231 RVsaSDGFWKSvatRVPKE-------PPEIRILNPYFIQEAAFTLIGLPFNNGLMGRGNIPTLGSVAVTMALHGCDEVAV 303
Cdd:cd23973   183 TI--PSGAYYG---RRPRSyfsgdftEDKYLVLHPDFLRYVKNRFLRSKTLKGKYWAIYRPTTGAFLLLTALHLCDTVSA 257

                         250       260
                  ....*....|....*....|..
gi 2287254631 304 AGF---GYDmstpNAPLHYYET 322
Cdd:cd23973   258 YGFiteDYR----KYPDHYYDK 275
GT29_ST6GAL1_2 cd23968
beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are ...
 142-323 5.83e-20

beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are beta-galactosidealpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the terminal galactose residue of a glycochain, by transfering sialic acid fromCMP-Sia. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467696  Cd Length: 266  Bit Score: 88.87  E-value: 5.83e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287254631 142 RRCIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPVKGFEKDVGSKTTLRITYPEgAMQRPEQ-------YERDSLFV--- 211
Cdd:cd23968    46 NTCAVVSSSGALLGSKLGKEIDSHDAVLRFNDAPTKGFEKDVGSKTTLRLINSQ-ILSKPEFnfltdplYRNVTLLVwdp 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287254631 212 -------LAGFKWQDFKWL-KYIVYKErvsasdgfwksvatRVPKEPPEirILNPYF-------IQEAAFTliglpfnng 276
Cdd:cd23968   125 ssynvnlEKWYKKPDFDFFpNYIKYRR--------------RHPEEPFY--LIDPRFlwrlwdiLQEYTPE--------- 179

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 2287254631 277 lMGRGNIPTLGSVAVTMALHGCDEVAVagFGYDMSTPNAPL-HYYETV 323
Cdd:cd23968   180 -KIKPNPPSSGFIGIVLMLHLCDWVDV--YEYVPSVRQTDRcHYYDVE 224
GT29_ST6GALNAC3_4_5_6 cd23965
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family ...
 141-322 2.89e-19

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, bytransfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substratespecificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467693  Cd Length: 225  Bit Score: 86.14  E-value: 2.89e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287254631 141 CRRCIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPVKGFEKDVGSKTTLRI----TYPEGAMQRPEQYERDS---LFVLa 213
Cdd:cd23965     1 CDTCALVSSSGQLLGSGAGKEIDSADCVIRMNDAPTRGYEKDVGRRTTIRVvshsSLPRLLRNAILLLAGTRaptVVVF- 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287254631 214 gfkwqdfkWLKYIVYKERVSASDGFWKSVATRVPKeppeiriLNPYFiqeaaftliglpFNNGLMGRGN--------IPT 285
Cdd:cd23965    80 --------WGPETKMNKDGAGKYNLLRSLSKKYPD-------VEFYS------------LTPEKMDYADelfeketgKSR 132

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2287254631 286 LGS--------VAVTMALHGCDEVAVagfgYDMSTPN---------APLHYYET 322
Cdd:cd23965   133 IKSgtwlstgwFTMLLALDVCDEIKV----YGMVPENycrehpnskVPYHYYEP 182
GT29_ST6GALNAC2 cd23972
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are ...
 101-324 1.51e-17

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467700  Cd Length: 308  Bit Score: 82.56  E-value: 1.51e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287254631 101 WARIREFVPPFGIKG-QDNLIKAILSV---TKEYRLTPALDS-LRCRRCIIVGNGGVLANKSLGSRIDDYDIVVRLNSAP 175
Cdd:cd23972    37 WDRLSQRKVPYGWKGlSHQVVASTLSLlndSANAKLFFPRDTpGKCIRCAVVGNGGILNGSRQGRAIDAHDYVFRLNGAV 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287254631 176 VKGFEKDVGSKTTLR-----------ITYPEGAMQRPEQyERDSLFVLAGFKWQDFKWLKYIVYKERV-SASDGFWKSVA 243
Cdd:cd23972   117 IKGFEEDVGTKTSFYgftvntmknslISYWNLGFTRTPQ-GQDLQYIFIPSDIRDYVMLRSAILGVPVpEGLDKGDRPHK 195

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287254631 244 TRVPKEPPE-IRILNPYFIQEAAFTLIGLPFNNGLMGRGNIPTLGSVAVTMALHGCDEVAVAGFgydmSTPNAPL---HY 319
Cdd:cd23972   196 YFGPEASAKkFKLLHPDFISYLTDRFLKSKLLNTHYGHLYMPSTGALMLLTALHTCDQVSAYGF----ITSNYWKfsdHY 271


                  ....*
gi 2287254631 320 YETVR 324
Cdd:cd23972   272 YERKK 276
GT29_ST8SIA cd23963
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are ...
 142-334 1.60e-16

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on their catalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467691  Cd Length: 274  Bit Score: 79.23  E-value: 1.60e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287254631 142 RRCIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPVKGFEKDVGSKTTL------RITYPEGAMQRPEQYERdslFVlagf 215
Cdd:cd23963    64 KTCAVVGNSGILLGSGCGKEIDSHDFVIRCNLPPIKGFEKDVGRKTNLttlnpsILKRRYNSLKKNRDRDK---FL---- 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287254631 216 kwQDFKWLK--YIVY-KERVSASDGFWKSVATRVPKEPPEIRIL--NP-YFIQEAAFtliglpfnNGLMGRGNIPTLGSV 289
Cdd:cd23963   137 --NRLKEYNgsILWYpKFSFKSSTNLLLKAARALKKNGLNLTVVysNPeHFLAVQKF--------WKRRGLEKRPSTGLY 206

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 2287254631 290 AVTMALHGCDEVAVAGF---GYDMSTPNAPLHYYEtvRMAAIKEPRPH 334
Cdd:cd23963   207 LVSLALTFCDEIHLYGFwpfPTDPNGRPVPYHYYD--DLSPSTKNKVH 252
GT29_ST8SIA2 cd23987
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase ...
 130-347 3.28e-15

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia2 catalyzes shorter polysialic acid formation of NCAMs than ST8Sia4. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467715  Cd Length: 278  Bit Score: 75.36  E-value: 3.28e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287254631 130 YRLTPALDSLRCRR---CIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPVKGFEKDVGSKTTLRI--------------- 191
Cdd:cd23987    50 YELLPRTSPLKNKHfktCAIVGNSGILLNSGCGREIDSHDFVIRCNLAPVEEYAKDVGTKTDLVTmnpsvvqrafedlvn 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287254631 192 -TYPEGAMQRPEQYERDSLFV---LAGFKWQDFKWLKYIVYKERVSASDGFwksvatrvpkepPEIRILNP---YFIQea 264
Cdd:cd23987   130 eTWKEKFLQRLQSLNGSILWIpafMAKGGEERVEWVNDLILKHHINVRTAY------------PSLRLLHAvrgYWLT-- 195

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287254631 265 aftliglpfNNGLMGRgniPTLGSVAVTMALHGCDEVAVAG---FGYDMSTPNAPLHYYETVRMAAIKEPRPHVENLNPS 341
Cdd:cd23987   196 ---------NKVHIKR---PTTGLLMYTLATRFCNRIHLYGfwpFPRDQNQNPVKYHYYDSLKYGYTSQASPHTMPLEFK 263


                  ....*.
gi 2287254631 342 ELRLPH 347
Cdd:cd23987   264 ALKNLH 269
GT29_ST6GALNAC4 cd23977
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are ...
 141-325 6.95e-15

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467705  Cd Length: 228  Bit Score: 73.36  E-value: 6.95e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287254631 141 CRRCIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPVKGFEKDVGSKTTLRI----TYPEGAMQRPE--QYERDSLFVLAG 214
Cdd:cd23977     1 CRRCAVVSSSGQMLGSGLGPEIDQQECVLRMNVAPTAGYEADVGNRSSLRVvshtSVPLLLRNQGYffQQSRDTKYVIWG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287254631 215 FKWQDFKWLKYIVYKervsasdgfwksVATRVPKEPPEIRIlnpYFIQEAAFTLIGLPFNN----GLMGRGNIPTLGSVA 290
Cdd:cd23977    81 PERNMDRDGGGKTYR------------ALLTLAKMYPHLQV---YTLTEEKMAYCDGVFQNetgkNRMKSGSFLSTGWFT 145

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 2287254631 291 VTMALHGCDEVAVAG-----FGYDMSTPNAPLHYYETVRM 325
Cdd:cd23977   146 MILALELCEEILVYGmvsdsYCRNKNHSSVPYHYYEKGRL 185
GT29_ST6GALNAC2L cd23974
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are ...
 141-324 2.13e-14

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467702  Cd Length: 309  Bit Score: 73.63  E-value: 2.13e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287254631 141 CRRCIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPVKGFEKDVGSKTTLRITYPEGAMQRPEQYERDSLFVLAGFKWQDF 220
Cdd:cd23974    84 CIRCAVVGNGGILNGSRMGAEIDGHDYVFRVNGAITKGFEKDVGRRTSFYTFSTNTLMNSLRAYAGVGFNGPPQSKETRY 163

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287254631 221 KWL-----KYIVYKERVSasdgfwKSVATRVP---KEPP----------EIRILNPYFIQEAAFTLIGLPFNNGLMGRGN 282
Cdd:cd23974   164 IFLpdhdrDYLLVKAALT------HTPIDRGRdksKRPSkyfgkdvtaeKFKIYHPDFIRYLRNRFLWSPILNTKQRDIY 237

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 2287254631 283 IPTLGSVAVTMALHGCDEVAVAGFgydmSTPNAPL---HYYETVR 324
Cdd:cd23974   238 RPSTGAVMLLAALHTCDQVSAYGF----MTPDYGKysdHYYDKTY 278
GT29_ST6GAL1 cd23985
beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside ...
 142-306 3.06e-14

beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by transfering sialic acid from CMP-Sia. ST6Gal1 play important roles in the immune system. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467713  Cd Length: 266  Bit Score: 72.43  E-value: 3.06e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287254631 142 RRCIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPVKGFEKDVGSKTTLRITYPEgAMQRPE-QYERDSLF---VL----- 212
Cdd:cd23985    46 GRCAVVSSAGSLKSSGLGREIDSHDAVLRFNGAPTAGFQQDVGTKTTIRLINSQ-LVTTEKhKFLKDSLYnegILivwdp 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287254631 213 AGFKWQDFKWLKYIVYK--ERvsasdgfWKSVATRVPKEPpeIRILNPYF-------IQEAAFTLIGL-PFNNGLMGrgn 282
Cdd:cd23985   125 APYHSDIPEWYKNPDYNffEN-------YKTYRRLNPNQP--FYILHPQMqwelwdiIQENSPEEIQPnPPSSGMLG--- 192

                         170       180
                  ....*....|....*....|....
gi 2287254631 283 iptlgsVAVTMALhgCDEVAVAGF 306
Cdd:cd23985   193 ------IILMMTL--CDQVDVYEF 208
GT29_ST6GAL2 cd23986
beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside ...
 142-327 4.80e-14

beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside alpha-2,3-sialyltransferases that catalyze an alpha2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by a transfering sialic acid from CMP-Sia. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467714  Cd Length: 270  Bit Score: 71.79  E-value: 4.80e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287254631 142 RRCIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPVKGFEKDVGSKTTLRITYPEGAMQRPEQYERDSLF---VL-----A 213
Cdd:cd23986    50 RSCAVVTSAGAILNSSLGKEIDSHDAVLRFNSAPTRGYEKDVGNKTTIRIINSQILTNPNHHFIDSSLYkdvILvawdpA 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287254631 214 GFKWQDFKWLK---------YIVYKErvsasdgfwksvatRVPKEPpeIRILNPYF-------IQEaaftliglpfNNGL 277
Cdd:cd23986   130 PYSANLHKWYKkpdynlftpYVQYRK--------------RNPNQP--FYILHPKFiwqlwdiIQE----------NTQE 183

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2287254631 278 MGRGNIPTLGSVAVTMALHGCDEVAVagFGYDMSTPNAPL-HYYETVRMAA 327
Cdd:cd23986   184 KIQPNPPSSGFIGILIMMSMCREVHV--YEYIPSVRQTDLcHYHERYYDAA 232
GT29_ST8SIA3_oligo cd23970
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2, ...
 130-321 6.42e-14

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3 synthesizes polysialic acid and has been shown to autopolysialylate. ST8Sia3 utilizes the Siaalpha2,3Galbeta1,4GlcNAc structure on N-glycans of glycoproteins and glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acidand the terminal sialic acid residues of glycochains, by transfering sialic acidfrom CMP-Sia and they belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467698  Cd Length: 284  Bit Score: 71.66  E-value: 6.42e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287254631 130 YRLTPA---LDSLRCRRCIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPVKGFEKDVGSKTTLrITYPEGAMQRpeQYER 206
Cdd:cd23970    54 RSLLPEvspFQNKHYNTCAVVGNSGILTNSQCGNEIDKSDFVFRCNFAPTEGFEKDVGRKTNL-TTFNPSILEK--YYNN 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287254631 207 dsLFVLagfkwQDFKwlkyiVYKERVSASDG--FWKSVATRvPKEPPEIRILNPYFIQEAAFTLIGLPFNNGLMGRGN-- 282
Cdd:cd23970   131 --LLTI-----QDRN-----NFFLSLKKLDGaiLWIPAFFF-HTSATVTRTLVDFFVEHRGQLKVQLAWPGNIMQHVNry 197

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2287254631 283 ----------IPTlGSVAVTMALHGCDEVAVAGF---GYDMSTPNAPLHYYE 321
Cdd:cd23970   198 wktkhlspkrLST-GILMYTLASAICEEIHLYGFwpfGFDPTGTPLPYHYYD 248
GT29_ST8SIA_poly cd23969
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be ...
 133-334 4.15e-13

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be polysialyltransferases, and they can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467697  Cd Length: 276  Bit Score: 68.98  E-value: 4.15e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287254631 133 TPALDSLRCRRCIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPVKGFEKDVGSKTTLRITYPE------GAMQRPEQYER 206
Cdd:cd23969    56 VSPLKGKHFRTCAVVGNSGILLNSGCGQEIDSHDFVIRCNLAPVEGYEKDVGTKSNLTTMNPSviphayGDLVNATDKEK 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287254631 207 ---------DSLFVLAGF--KW--QDFKWLKYIVYKERVSASDGFwksvatrvpkepPEIRILNpyfiqeaafTLIGLPF 273
Cdd:cd23969   136 fverlrqlgDSILWIPAFvsKGgeEHVQWTNEIILKHKLNVKTAY------------PPLRLNH---------AIRGYWL 194

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2287254631 274 NNGLmgRGNIPTLGSVAVTMALHGCDEVAVAG---FGYDMSTPNAPLHYYETVRMAAikEPRPH 334
Cdd:cd23969   195 TTKF--RIKRPSTGLLMYTLATRFCDEIHLYGfypFSEDGNGRAVKYHYYDNRKYLT--TARPH 254
GT29_ST8SIA4 cd23988
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase ...
 130-347 3.96e-12

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia4 catalyzes longer polysialicacid formation of NCAMs than ST8Sia2. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467716  Cd Length: 278  Bit Score: 66.13  E-value: 3.96e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287254631 130 YRLTPALDSLRCRR---CIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPVKGFEKDVGSKTTLRITYPE------GAMQR 200
Cdd:cd23988    50 HSLLPEVSPMKNRRfktCAVVGNSGILLDSGCGKEIDSHDFVIRCNLAPVVEFAADVGTKSDFITMNPSvvqrafGGFRN 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287254631 201 PEQYER---------DSLFVLAGFK----WQDFKWLKYIVYKERVSASDGFwksvatrvpkepPEIRILNpyfiqeaafT 267
Cdd:cd23988   130 ESDREKfvhrlsmlnDSVLWIPAFMvkggEKHVEWVNALILKNKLKVRTAY------------PSLRLIH---------A 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287254631 268 LIGLPFNNGLmgrgNI--PTLGSVAVTMALHGCDEVAVAG---FGYDMSTPNAPLHYYETVRMAAIKEPRPHVENLNPSE 342
Cdd:cd23988   189 VRGYWLTNKV----NIkrPSTGLLMYTLATRFCDEIHLYGfwpFPKDANGNPVKYHYYDDLKYRYFSNAGPHRMPLEFKT 264


                  ....*
gi 2287254631 343 LRLPH 347
Cdd:cd23988   265 LNVLH 269
GT29_ST8SIA_mono cd23971
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are ...
 143-342 6.30e-12

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on theircatalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467699  Cd Length: 271  Bit Score: 65.74  E-value: 6.30e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287254631 143 RCIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPVKgFEKDVGSKTTL--------RITYPEGAMQRPEQYER-----DSL 209
Cdd:cd23971    66 TCAVVGNGGILKNSSCGREIDSADFVIRCNLPPLN-DSKDVGSKTNLvtanpsilREKFHNLKKRRRPFVERmkvygNAL 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287254631 210 FVLAGFKW--------------QDFKWLKYIVY--KERVSASDGFWKSVATRvpkeppEIRIlnpyfiqeaaftliglpf 273
Cdd:cd23971   145 LLLPAFSYtsntepslralytlEDFGSPQKVLFfnPEYLRNLSRYWKSKGLK------ARRL------------------ 200

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2287254631 274 NNGLMgrgniptlgsvAVTMALHGCDEVAVAGF---GYDMSTPNAPLHYYETVRmaaikePRPHVENLnPSE 342
Cdd:cd23971   201 STGLM-----------LVSAALELCENVHLYGFwpfSTDLDGNPISHHYYDNVL------PKKGVHAM-PEE 254
GT29_ST8SIA6 cd23991
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2, ...
 121-189 2.38e-11

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6 (also known as alpha-2,8-sialyltransferase 8F) prefers O-glycans to N-glycans or glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29(GT29).


Pssm-ID: 467719  Cd Length: 273  Bit Score: 64.00  E-value: 2.38e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2287254631 121 KAILSVTKEYRLTPALDSLRCR---RCIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPVKG-FEKDVGSKTTL 189
Cdd:cd23991    41 KKILITENIFRMFPKSQPFRGYpykQCAVVGNGGILKNSSCGAEIDQADFVFRCNLPPTGGnISKDVGSKTNL 113
GT29_ST6GALNAC3 cd23975
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are ...
 141-324 1.64e-10

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467703  Cd Length: 226  Bit Score: 60.72  E-value: 1.64e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287254631 141 CRRCIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPVKGFEKDVGSKTTLRI---TYPEGAMQRPEQYERD---SLFVLag 214
Cdd:cd23975     1 CDLCAVVSNSGQMVGQKVGAEIDQSSCIWRMNNAPTKGYEEDVGKRTTIRVvshTSVPLLLKNPDYFFKEtneTIYVI-- 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287254631 215 fkWQDFKWLK-----------------------YIVYKERVSASDGFWKsvatrvpKEPPEIRILNPYFIQEAAFTLIgl 271
Cdd:cd23975    79 --WGPFRNMRkdgkgivynmlkkavesypqakiYVTTEKRMSYCDTVFK-------KETGKDRVQSGSYLSTGWFTLI-- 147

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2287254631 272 pfnnglmgrgniptlgsvavtMALHGCDEVAVAGFGYDMSTPN-----APLHYYETVR 324
Cdd:cd23975   148 ---------------------LAMDACYGIHVYGMINDTYCKTegyrkVPYHYYEPGR 184
GT29_ST6GALNAC5 cd23976
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are ...
 139-321 3.15e-10

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilize Sia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467704  Cd Length: 244  Bit Score: 60.27  E-value: 3.15e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287254631 139 LRCRRCIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPVKGFEKDVGSKTTLRITyPEGAMQR--PEQYE-----RDSLFV 211
Cdd:cd23976    13 MHCKSCALVTSSGHLTGSNRGNEIDETECVIRMNDAPTRGYGKDVGNKTSLRVI-AHSSIQRilRNRNEllnvsQGTVFI 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287254631 212 LAG---FKWQDFKWLKY----------------IVYKERVSASDGFWKsvatrvpKEPPEIRILNPYFIQEAAFTLiglp 272
Cdd:cd23976    92 FWGpsnYMRRDGKGLVYnnlqlmnqilpklkvyTITRHKMLQFDELFK-------RETGKDRKISNTWLSTGWFTM---- 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2287254631 273 fnnglmgrgniptlgsvavTMALHGCDEVAVAG-----FGYDMSTPNAPLHYYE 321
Cdd:cd23976   161 -------------------IIALELCDRINVYGmvppdFCRDPNHPSVPYHYYE 195
GT29_ST6GALNAC6 cd23978
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are ...
 141-191 3.34e-10

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467706  Cd Length: 229  Bit Score: 59.87  E-value: 3.34e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2287254631 141 CRRCIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPVKGFEKDVGSKTTLRI 191
Cdd:cd23978     1 CHQCALITSSSHLLGTSLGPEIDQTECTIRMNDAPTTGYEKDVGNKTTLRV 51
GT29_ST8SIA5 cd23990
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2, ...
 142-355 1.10e-08

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5 (also known as alpha-2,8-sialyltransferase 8E) is involved in the biosynthesis of gangliosides, such as GD1c, GT1a, GQ1b, and GT3. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467718  Cd Length: 273  Bit Score: 56.00  E-value: 1.10e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287254631 142 RRCIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPV-KGFEKDVGSKTTLRITYPEGAMQRPEQYErdslfvlagfKWQDF 220
Cdd:cd23990    65 KKCAVVGNGGILKNSKCGREIDSADFVFRCNLPPIsEKYVRDVGVKTDVVTINPSIITERFHKLE----------KWRRP 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287254631 221 KWLKYIVYKERVSASDGFWKS----VATRVP------KEPPEIRILNP-YFIQEAAFTLiglpfNNGLmgRGNIPTLGSV 289
Cdd:cd23990   135 FYEVLQVYENASVVLPAFYNTrntdVSIRVKyvlddfESQQAVYYFHPqYLLNVSRFWL-----RQGV--RAKRISSGLM 207

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2287254631 290 AVTMALHGCDEVAVAGF-GYDMSTPNAPL--HYYETVRmaaikePRPHVENLnPSELrlphFCFDHQPS 355
Cdd:cd23990   208 LVTAALELCEEVHLYGFwAFPMNPSGIFIthHYYDNVK------PRPGFHAM-PSEI----FNFLHMHS 265
GT29_ST8SIA1 cd23989
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2, ...
 139-323 3.51e-08

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1 (also known as ganglioside GD3 synthase) adds sialic acids to GM3 ganglioside. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze analpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467717  Cd Length: 272  Bit Score: 54.45  E-value: 3.51e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287254631 139 LRCRRCIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPV-KGFEKDVGSKTTLRITYPEGAMQRPEQ--YERDSLfvLAGF 215
Cdd:cd23989    61 LPLKKCSVVGNGGILKNSGCGQQIDRADFVMRCNLPPLsREYTDDVGTKTQLVTANPSIIDKRFQNllWSRKSF--VESM 138

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287254631 216 KWQDFKWLKYIVYKERVSASDGFWKSVATRVPKEPPEIRILNPYFIQEaaftlIGLPFNNGLMGRGNIPTlGSVAVTMAL 295
Cdd:cd23989   139 KVYGRSYIYMPAFSMKTGTDPSLRVYYTLADVGANQTVLFANPNFLRN-----VGKFWKSKGVHAKRLST-GLFLVSAAL 212

                         170       180       190
                  ....*....|....*....|....*....|.
gi 2287254631 296 HGCDEVAVAGF-GYDMSTPNAPL--HYYETV 323
Cdd:cd23989   213 GLCEEVTIYGFwPFSVDLDERTIshHYYDNV 243
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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