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Conserved domains on  [gi|2257907477|ref|NP_001395593|]
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WD repeat-containing protein 62 isoform 7 [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1019192)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
364-744 1.50e-36

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 143.90  E-value: 1.50e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257907477  364 ALTFDPVHQWLSCVYKDHSIYIWDVKDIDEVSKIWSelfHSSFVWNVevypefedqrACLPSGTFL-TCSSDNTIRFWNL 442
Cdd:COG2319     83 SVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTG---HTGAVRSV----------AFSPDGKTLaSGSADGTVRLWDL 149

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257907477  443 DSAsdtrwqknifsdsllkvvyvendiQHLQDLSHFPDRgsengtpmdmkagVRVMQVSPDGQHLASGDRSGNLRIHELH 522
Cdd:COG2319    150 ATG------------------------KLLRTLTGHSGA-------------VTSVAFSPDGKLLASGSDDGTVRLWDLA 192

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257907477  523 FMDELIKVEAHDAEVLCLEYSkPEtGvTLLASASRDRLIHVLNVEKNyNLEQTLDDHSSSITAIKFagTRDVQMI-SCGA 601
Cdd:COG2319    193 TGKLLRTLTGHTGAVRSVAFS-PD-G-KLLASGSADGTVRLWDLATG-KLLRTLTGHSGSVRSVAF--SPDGRLLaSGSA 266

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257907477  602 DKSIYFRSAQqaSDGLHFVRTHHVAektTLYDMDIDITQKYVAVACQDRNVRVYNTVSGKQKKCYKGSQGDEGSllkVHV 681
Cdd:COG2319    267 DGTVRLWDLA--TGELLRTLTGHSG---GVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRS---VAF 338

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2257907477  682 DPSGTFLATSCSDKSISLIDFYSGECVAKMFGHSEIVTGMKFTYDCRHLITVSGDSCVFIWHL 744
Cdd:COG2319    339 SPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
93-444 8.62e-23

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 102.68  E-value: 8.62e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257907477   93 VVVLNPKENKQQHIFNTTRKSLSALAFSPDGKYIVTGenGHRPAVRIWDVEEKTQVAEMLGHKYGVACVAFSPNMKHIVS 172
Cdd:COG2319    144 VRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASG--SDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLAS 221

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257907477  173 MGYqhDMVLNVWDWKKDIVVASNKV-SCRVIALSFSEDSSYFVTVG-NRHVRFWflEASTEAKVTStvpLVGRSGilgel 250
Cdd:COG2319    222 GSA--DGTVRLWDLATGKLLRTLTGhSGSVRSVAFSPDGRLLASGSaDGTVRLW--DLATGELLRT---LTGHSG----- 289

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257907477  251 hnnifcgvacgrgrmagntfcvsysgllcqfnekrvldkWINlkvslssCLCVS--DELIFCGCTDGIVRIFQAHSLLYL 328
Cdd:COG2319    290 ---------------------------------------GVN-------SVAFSpdGKLLASGSDDGTVRLWDLATGKLL 323

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257907477  329 TNLpKPHYLGVDvahgldssflfhrkaeavypdtvALTFDPVHQWLSCVYKDHSIYIWDVKDIDEVSKIWSelfHSSFVW 408
Cdd:COG2319    324 RTL-TGHTGAVR-----------------------SVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTG---HTGAVT 376

                          330       340       350
                   ....*....|....*....|....*....|....*..
gi 2257907477  409 NVevypefedqrACLPSGTFL-TCSSDNTIRFWNLDS 444
Cdd:COG2319    377 SV----------AFSPDGRTLaSGSADGTVRLWDLAT 403
Atrophin-1 super family cl38111
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 983-1447 6.02e-06

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


The actual alignment was detected with superfamily member pfam03154:

Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 51.31  E-value: 6.02e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257907477  983 EETEAGPEDQQGDTYLRVSSVSS-KDQSPPEDSGESEAELECS---FAAAHSSAPQTDPGPHLTMTAEYPsTEELSQPEL 1058
Cdd:pfam03154  128 DEGSSDPKDIDQDNRSTSPSIPSpQDNESDSDSSAQQQILQTQppvLQAQSGAASPPSPPPPGTTQAATA-GPTPSAPSV 206

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257907477 1059 PGLGNGSLPQTPEQEKflrhhfetltdapteelfhGSLGDIKISETEDYFFNPRLSISTqflSRLQKTSRCPPrlPLHLM 1138
Cdd:pfam03154  207 PPQGSPATSQPPNQTQ-------------------STAAPHTLIQQTPTLHPQRLPSPH---PPLQPMTQPPP--PSQVS 262

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257907477 1139 KSPEAQPVGQGGNQPKAGPLRAGTGYMSSDGTNVLSGQKAEETQEALslldrkPPTPTSVLTTGREQSISAPSSCSYLES 1218
Cdd:pfam03154  263 PQPLPQPSLHGQMPPMPHSLQTGPSHMQHPVPPQPFPLTPQSSQSQV------PPGPSPAAPGQSQQRIHTPPSQSQLQS 336

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257907477 1219 -------------TTSSHAKTTRSISLGDSEGPVTAELPQSLHKPlSPGQELQAIPTTVALT--SSIKDHEPAplswgnh 1283
Cdd:pfam03154  337 qqppreqplppapLSMPHIKPPPTTPIPQLPNPQSHKHPPHLSGP-SPFQMNSNLPPPPALKplSSLSTHHPP------- 408

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257907477 1284 eARASLKLTLSSVCEQLLSPPPQEPPITHVWSQEP--VDVPPSMAVTVASFCAPSP-----VDMSTLGLHSSMFLPKTSA 1356
Cdd:pfam03154  409 -SAHPPPLQLMPQSQQLPPPPAQPPVLTQSQSLPPpaASHPPTSGLHQVPSQSPFPqhpfvPGGPPPITPPSGPPTSTSS 487

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257907477 1357 SGPLTPPAHLQLLETRSRVPGSTAALLEPT------PDASGVIADSPGHWDTEVPTPELlgsVESVLHRLQTA-FQEAL- 1428
Cdd:pfam03154  488 AMPGIQPPSSASVSSSGPVPAAVSCPLPPVqikeeaLDEAEEPESPPPPPRSPSPEPTV---VNTPSHASQSArFYKHLd 564

                          490       500
                   ....*....|....*....|....*...
gi 2257907477 1429 ---------DLYRMLVSSSQLGPEQQQA 1447
Cdd:pfam03154  565 rgynscartDLYFMPLAGSKLAKKREEA 592
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
364-744 1.50e-36

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 143.90  E-value: 1.50e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257907477  364 ALTFDPVHQWLSCVYKDHSIYIWDVKDIDEVSKIWSelfHSSFVWNVevypefedqrACLPSGTFL-TCSSDNTIRFWNL 442
Cdd:COG2319     83 SVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTG---HTGAVRSV----------AFSPDGKTLaSGSADGTVRLWDL 149

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257907477  443 DSAsdtrwqknifsdsllkvvyvendiQHLQDLSHFPDRgsengtpmdmkagVRVMQVSPDGQHLASGDRSGNLRIHELH 522
Cdd:COG2319    150 ATG------------------------KLLRTLTGHSGA-------------VTSVAFSPDGKLLASGSDDGTVRLWDLA 192

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257907477  523 FMDELIKVEAHDAEVLCLEYSkPEtGvTLLASASRDRLIHVLNVEKNyNLEQTLDDHSSSITAIKFagTRDVQMI-SCGA 601
Cdd:COG2319    193 TGKLLRTLTGHTGAVRSVAFS-PD-G-KLLASGSADGTVRLWDLATG-KLLRTLTGHSGSVRSVAF--SPDGRLLaSGSA 266

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257907477  602 DKSIYFRSAQqaSDGLHFVRTHHVAektTLYDMDIDITQKYVAVACQDRNVRVYNTVSGKQKKCYKGSQGDEGSllkVHV 681
Cdd:COG2319    267 DGTVRLWDLA--TGELLRTLTGHSG---GVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRS---VAF 338

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2257907477  682 DPSGTFLATSCSDKSISLIDFYSGECVAKMFGHSEIVTGMKFTYDCRHLITVSGDSCVFIWHL 744
Cdd:COG2319    339 SPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 364-742 3.27e-27

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 113.20  E-value: 3.27e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257907477  364 ALTFDPVHQWLSCVYKDHSIYIWDVKDIDEVSKIWSelfHSSFVWNVevypefedqRACLPSGTFLTCSSDNTIRFWNLD 443
Cdd:cd00200     14 CVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKG---HTGPVRDV---------AASADGTYLASGSSDKTIRLWDLE 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257907477  444 SASDTRwqknIFsdsllkvvyvendIQHLQDlshfpdrgsengtpmdmkagVRVMQVSPDGQHLASGDRSGNLRIHELHF 523
Cdd:cd00200     82 TGECVR----TL-------------TGHTSY--------------------VSSVAFSPDGRILSSSSRDKTIKVWDVET 124

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257907477  524 MDELIKVEAHDAEVLCLEYSKPETgvtLLASASRDRLIHVLNVEKNYnLEQTLDDHSSSITAIKFAGTRDvQMISCGADK 603
Cdd:cd00200    125 GKCLTTLRGHTDWVNSVAFSPDGT---FVASSSQDGTIKLWDLRTGK-CVATLTGHTGEVNSVAFSPDGE-KLLSSSSDG 199

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257907477  604 SIyfrsaqqasdglhfvrthhvaekttlydmdiditqkyvavacqdrnvRVYNTVSGKQKKCYkgsQGDEGSLLKVHVDP 683
Cdd:cd00200    200 TI-----------------------------------------------KLWDLSTGKCLGTL---RGHENGVNSVAFSP 229

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2257907477  684 SGTFLATSCSDKSISLIDFYSGECVAKMFGHSEIVTGMKFTYDCRHLITVSGDSCVFIW 742
Cdd:cd00200    230 DGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
93-444 8.62e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 102.68  E-value: 8.62e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257907477   93 VVVLNPKENKQQHIFNTTRKSLSALAFSPDGKYIVTGenGHRPAVRIWDVEEKTQVAEMLGHKYGVACVAFSPNMKHIVS 172
Cdd:COG2319    144 VRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASG--SDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLAS 221

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257907477  173 MGYqhDMVLNVWDWKKDIVVASNKV-SCRVIALSFSEDSSYFVTVG-NRHVRFWflEASTEAKVTStvpLVGRSGilgel 250
Cdd:COG2319    222 GSA--DGTVRLWDLATGKLLRTLTGhSGSVRSVAFSPDGRLLASGSaDGTVRLW--DLATGELLRT---LTGHSG----- 289

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257907477  251 hnnifcgvacgrgrmagntfcvsysgllcqfnekrvldkWINlkvslssCLCVS--DELIFCGCTDGIVRIFQAHSLLYL 328
Cdd:COG2319    290 ---------------------------------------GVN-------SVAFSpdGKLLASGSDDGTVRLWDLATGKLL 323

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257907477  329 TNLpKPHYLGVDvahgldssflfhrkaeavypdtvALTFDPVHQWLSCVYKDHSIYIWDVKDIDEVSKIWSelfHSSFVW 408
Cdd:COG2319    324 RTL-TGHTGAVR-----------------------SVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTG---HTGAVT 376

                          330       340       350
                   ....*....|....*....|....*....|....*..
gi 2257907477  409 NVevypefedqrACLPSGTFL-TCSSDNTIRFWNLDS 444
Cdd:COG2319    377 SV----------AFSPDGRTLaSGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 111-441 1.85e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 99.33  E-value: 1.85e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257907477  111 RKSLSALAFSPDGKYIVTG-ENGHrpaVRIWDVEEKTQVAEMLGHKYGVACVAFSPNMKHIVSMGYqhDMVLNVWDWKKD 189
Cdd:cd00200      9 TGGVTCVAFSPDGKLLATGsGDGT---IKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSS--DKTIRLWDLETG 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257907477  190 IVVAS-NKVSCRVIALSFSEDSSYFVTVG-NRHVRFWFLEASTEAKVTSTvplvgrsgilgelHNN-IFCGVACGRGRMA 266
Cdd:cd00200     84 ECVRTlTGHTSYVSSVAFSPDGRILSSSSrDKTIKVWDVETGKCLTTLRG-------------HTDwVNSVAFSPDGTFV 150

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257907477  267 gntFCVSYSGL-----LCQFNEKRVL---DKWINlkvslssCLCVSD--ELIFCGCTDGIVRIFqahsllyltNLPKPHY 336
Cdd:cd00200    151 ---ASSSQDGTiklwdLRTGKCVATLtghTGEVN-------SVAFSPdgEKLLSSSSDGTIKLW---------DLSTGKC 211

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257907477  337 LGVDVAHGldssflfhrkaEAVYpdtvALTFDPVHQWLSCVYKDHSIYIWDVKDIDEVSKIWSelfHSSFVWNVevypef 416
Cdd:cd00200    212 LGTLRGHE-----------NGVN----SVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSG---HTNSVTSL------ 267

                          330       340
                   ....*....|....*....|....*.
gi 2257907477  417 edqrACLPSGTFL-TCSSDNTIRFWN 441
Cdd:cd00200    268 ----AWSPDGKRLaSGSADGTIRIWD 289
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 983-1447 6.02e-06

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 51.31  E-value: 6.02e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257907477  983 EETEAGPEDQQGDTYLRVSSVSS-KDQSPPEDSGESEAELECS---FAAAHSSAPQTDPGPHLTMTAEYPsTEELSQPEL 1058
Cdd:pfam03154  128 DEGSSDPKDIDQDNRSTSPSIPSpQDNESDSDSSAQQQILQTQppvLQAQSGAASPPSPPPPGTTQAATA-GPTPSAPSV 206

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257907477 1059 PGLGNGSLPQTPEQEKflrhhfetltdapteelfhGSLGDIKISETEDYFFNPRLSISTqflSRLQKTSRCPPrlPLHLM 1138
Cdd:pfam03154  207 PPQGSPATSQPPNQTQ-------------------STAAPHTLIQQTPTLHPQRLPSPH---PPLQPMTQPPP--PSQVS 262

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257907477 1139 KSPEAQPVGQGGNQPKAGPLRAGTGYMSSDGTNVLSGQKAEETQEALslldrkPPTPTSVLTTGREQSISAPSSCSYLES 1218
Cdd:pfam03154  263 PQPLPQPSLHGQMPPMPHSLQTGPSHMQHPVPPQPFPLTPQSSQSQV------PPGPSPAAPGQSQQRIHTPPSQSQLQS 336

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257907477 1219 -------------TTSSHAKTTRSISLGDSEGPVTAELPQSLHKPlSPGQELQAIPTTVALT--SSIKDHEPAplswgnh 1283
Cdd:pfam03154  337 qqppreqplppapLSMPHIKPPPTTPIPQLPNPQSHKHPPHLSGP-SPFQMNSNLPPPPALKplSSLSTHHPP------- 408

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257907477 1284 eARASLKLTLSSVCEQLLSPPPQEPPITHVWSQEP--VDVPPSMAVTVASFCAPSP-----VDMSTLGLHSSMFLPKTSA 1356
Cdd:pfam03154  409 -SAHPPPLQLMPQSQQLPPPPAQPPVLTQSQSLPPpaASHPPTSGLHQVPSQSPFPqhpfvPGGPPPITPPSGPPTSTSS 487

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257907477 1357 SGPLTPPAHLQLLETRSRVPGSTAALLEPT------PDASGVIADSPGHWDTEVPTPELlgsVESVLHRLQTA-FQEAL- 1428
Cdd:pfam03154  488 AMPGIQPPSSASVSSSGPVPAAVSCPLPPVqikeeaLDEAEEPESPPPPPRSPSPEPTV---VNTPSHASQSArFYKHLd 564

                          490       500
                   ....*....|....*....|....*...
gi 2257907477 1429 ---------DLYRMLVSSSQLGPEQQQA 1447
Cdd:pfam03154  565 rgynscartDLYFMPLAGSKLAKKREEA 592
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 704-743 2.92e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.68  E-value: 2.92e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 2257907477   704 SGECVAKMFGHSEIVTGMKFTYDCRHLITVSGDSCVFIWH 743
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
705-742 1.88e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.02  E-value: 1.88e-04
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2257907477  705 GECVAKMFGHSEIVTGMKFTYDCRHLITVSGDSCVFIW 742
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 145-185 4.37e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.52  E-value: 4.37e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 2257907477   145 KTQVAEMLGHKYGVACVAFSPNMKHIVSMGYqhDMVLNVWD 185
Cdd:smart00320    2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSD--DGTIKLWD 40
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
364-744 1.50e-36

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 143.90  E-value: 1.50e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257907477  364 ALTFDPVHQWLSCVYKDHSIYIWDVKDIDEVSKIWSelfHSSFVWNVevypefedqrACLPSGTFL-TCSSDNTIRFWNL 442
Cdd:COG2319     83 SVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTG---HTGAVRSV----------AFSPDGKTLaSGSADGTVRLWDL 149

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257907477  443 DSAsdtrwqknifsdsllkvvyvendiQHLQDLSHFPDRgsengtpmdmkagVRVMQVSPDGQHLASGDRSGNLRIHELH 522
Cdd:COG2319    150 ATG------------------------KLLRTLTGHSGA-------------VTSVAFSPDGKLLASGSDDGTVRLWDLA 192

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257907477  523 FMDELIKVEAHDAEVLCLEYSkPEtGvTLLASASRDRLIHVLNVEKNyNLEQTLDDHSSSITAIKFagTRDVQMI-SCGA 601
Cdd:COG2319    193 TGKLLRTLTGHTGAVRSVAFS-PD-G-KLLASGSADGTVRLWDLATG-KLLRTLTGHSGSVRSVAF--SPDGRLLaSGSA 266

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257907477  602 DKSIYFRSAQqaSDGLHFVRTHHVAektTLYDMDIDITQKYVAVACQDRNVRVYNTVSGKQKKCYKGSQGDEGSllkVHV 681
Cdd:COG2319    267 DGTVRLWDLA--TGELLRTLTGHSG---GVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRS---VAF 338

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2257907477  682 DPSGTFLATSCSDKSISLIDFYSGECVAKMFGHSEIVTGMKFTYDCRHLITVSGDSCVFIWHL 744
Cdd:COG2319    339 SPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 364-742 3.27e-27

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 113.20  E-value: 3.27e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257907477  364 ALTFDPVHQWLSCVYKDHSIYIWDVKDIDEVSKIWSelfHSSFVWNVevypefedqRACLPSGTFLTCSSDNTIRFWNLD 443
Cdd:cd00200     14 CVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKG---HTGPVRDV---------AASADGTYLASGSSDKTIRLWDLE 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257907477  444 SASDTRwqknIFsdsllkvvyvendIQHLQDlshfpdrgsengtpmdmkagVRVMQVSPDGQHLASGDRSGNLRIHELHF 523
Cdd:cd00200     82 TGECVR----TL-------------TGHTSY--------------------VSSVAFSPDGRILSSSSRDKTIKVWDVET 124

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257907477  524 MDELIKVEAHDAEVLCLEYSKPETgvtLLASASRDRLIHVLNVEKNYnLEQTLDDHSSSITAIKFAGTRDvQMISCGADK 603
Cdd:cd00200    125 GKCLTTLRGHTDWVNSVAFSPDGT---FVASSSQDGTIKLWDLRTGK-CVATLTGHTGEVNSVAFSPDGE-KLLSSSSDG 199

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257907477  604 SIyfrsaqqasdglhfvrthhvaekttlydmdiditqkyvavacqdrnvRVYNTVSGKQKKCYkgsQGDEGSLLKVHVDP 683
Cdd:cd00200    200 TI-----------------------------------------------KLWDLSTGKCLGTL---RGHENGVNSVAFSP 229

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2257907477  684 SGTFLATSCSDKSISLIDFYSGECVAKMFGHSEIVTGMKFTYDCRHLITVSGDSCVFIW 742
Cdd:cd00200    230 DGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 492-744 4.92e-27

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 112.81  E-value: 4.92e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257907477  492 KAGVRVMQVSPDGQHLASGDRSGNLRIHELHFMDELIKVEAHDAEVLCLEYSKpetGVTLLASASRDRLIHVLNVEKNyN 571
Cdd:cd00200      9 TGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASA---DGTYLASGSSDKTIRLWDLETG-E 84

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257907477  572 LEQTLDDHSSSITAIKFAGTRDVqMISCGADKSIyfRSAQQASDGLHFVRTHHvaeKTTLYDMDIDITQKYVAVACQDRN 651
Cdd:cd00200     85 CVRTLTGHTSYVSSVAFSPDGRI-LSSSSRDKTI--KVWDVETGKCLTTLRGH---TDWVNSVAFSPDGTFVASSSQDGT 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257907477  652 VRVYNTVSGKqkkCYKGSQGDEGSLLKVHVDPSGTFLATSCSDKSISLIDFYSGECVAKMFGHSEIVTGMKFTYDCRHLI 731
Cdd:cd00200    159 IKLWDLRTGK---CVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLA 235

                          250
                   ....*....|...
gi 2257907477  732 TVSGDSCVFIWHL 744
Cdd:cd00200    236 SGSEDGTIRVWDL 248
WD40 COG2319
WD40 repeat [General function prediction only];
42-567 1.30e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 111.16  E-value: 1.30e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257907477   42 LRRRTRLAAAPEDTVQNRVTLEKVLGITAQNSSGLTCDPGTGHVAYLAGCVVVVLNPKENKQQHIFNTTRKSLSALAFSP 121
Cdd:COG2319      9 LAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSP 88

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257907477  122 DGKYIVTGenGHRPAVRIWDVEEKTQVAEMLGHKYGVACVAFSPNMKHIVSMGYQHdmVLNVWDWKKDIVVAS-NKVSCR 200
Cdd:COG2319     89 DGRLLASA--SADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADG--TVRLWDLATGKLLRTlTGHSGA 164

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257907477  201 VIALSFSEDSSYFVTVG-NRHVRFWFLEASTEAKVtstvpLVGrsgilgelHNNIFCGVAcgrgrmagntfcVSYSGllc 279
Cdd:COG2319    165 VTSVAFSPDGKLLASGSdDGTVRLWDLATGKLLRT-----LTG--------HTGAVRSVA------------FSPDG--- 216

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257907477  280 qfnekrvldkwinlkvslssclcvsdELIFCGCTDGIVRIFQAHSLLYLTNLPkphylgvdvAHGldssflfhrkaEAVY 359
Cdd:COG2319    217 --------------------------KLLASGSADGTVRLWDLATGKLLRTLT---------GHS-----------GSVR 250

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257907477  360 pdtvALTFDPVHQWLSCVYKDHSIYIWDVKDiDEVSKIWSElfHSSFVWNVevypefedqrACLPSGTFL-TCSSDNTIR 438
Cdd:COG2319    251 ----SVAFSPDGRLLASGSADGTVRLWDLAT-GELLRTLTG--HSGGVNSV----------AFSPDGKLLaSGSDDGTVR 313

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257907477  439 FWNLDSAsdtrwqknifsdsllkvvyvendiQHLQDLSHFPDRgsengtpmdmkagVRVMQVSPDGQHLASGDRSGNLRI 518
Cdd:COG2319    314 LWDLATG------------------------KLLRTLTGHTGA-------------VRSVAFSPDGKTLASGSDDGTVRL 356

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....*....
gi 2257907477  519 HELHFMDELIKVEAHDAEVLCLEYSKPEtgvTLLASASRDRLIHVLNVE 567
Cdd:COG2319    357 WDLATGELLRTLTGHTGAVTSVAFSPDG---RTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 533-742 2.93e-25

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 107.42  E-value: 2.93e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257907477  533 HDAEVLCLEYSkpeTGVTLLASASRDRLIHVLNVEKNyNLEQTLDDHSSSITAIKFAGTRDvQMISCGADKSIYFrsaqQ 612
Cdd:cd00200      8 HTGGVTCVAFS---PDGKLLATGSGDGTIKVWDLETG-ELLRTLKGHTGPVRDVAASADGT-YLASGSSDKTIRL----W 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257907477  613 ASDGLHFVRTHHVAEKTtLYDMDIDITQKYVAVACQDRNVRVYNTVSGKQKKCYKGSQGDegsLLKVHVDPSGTFLATSC 692
Cdd:cd00200     79 DLETGECVRTLTGHTSY-VSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDW---VNSVAFSPDGTFVASSS 154

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|
gi 2257907477  693 SDKSISLIDFYSGECVAKMFGHSEIVTGMKFTYDCRHLITVSGDSCVFIW 742
Cdd:cd00200    155 QDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLW 204
WD40 COG2319
WD40 repeat [General function prediction only];
480-750 2.49e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 104.61  E-value: 2.49e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257907477  480 DRGSENGTPMDMKAGVRVMQVSPDGQHLASGDRSGNLRIHELHFMDELIKVEAHDAEVLCLEYSkPETgvTLLASASRDR 559
Cdd:COG2319     66 AAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFS-PDG--KTLASGSADG 142

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257907477  560 LIHVLNVEKNyNLEQTLDDHSSSITAIKFA--GTRdvqMISCGADKSIYFRSAQQASDgLHFVRTHhvaeKTTLYDMDID 637
Cdd:COG2319    143 TVRLWDLATG-KLLRTLTGHSGAVTSVAFSpdGKL---LASGSDDGTVRLWDLATGKL-LRTLTGH----TGAVRSVAFS 213

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257907477  638 ITQKYVAVACQDRNVRVYNTVSGKQKKCYKGsqgDEGSLLKVHVDPSGTFLATSCSDKSISLIDFYSGECVAKMFGHSEI 717
Cdd:COG2319    214 PDGKLLASGSADGTVRLWDLATGKLLRTLTG---HSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGG 290

                          250       260       270
                   ....*....|....*....|....*....|....*
gi 2257907477  718 VTGMKFTYDCRHLITVSGDSCVFIWHL--GPEITT 750
Cdd:COG2319    291 VNSVAFSPDGKLLASGSDDGTVRLWDLatGKLLRT 325
WD40 COG2319
WD40 repeat [General function prediction only];
93-444 8.62e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 102.68  E-value: 8.62e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257907477   93 VVVLNPKENKQQHIFNTTRKSLSALAFSPDGKYIVTGenGHRPAVRIWDVEEKTQVAEMLGHKYGVACVAFSPNMKHIVS 172
Cdd:COG2319    144 VRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASG--SDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLAS 221

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257907477  173 MGYqhDMVLNVWDWKKDIVVASNKV-SCRVIALSFSEDSSYFVTVG-NRHVRFWflEASTEAKVTStvpLVGRSGilgel 250
Cdd:COG2319    222 GSA--DGTVRLWDLATGKLLRTLTGhSGSVRSVAFSPDGRLLASGSaDGTVRLW--DLATGELLRT---LTGHSG----- 289

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257907477  251 hnnifcgvacgrgrmagntfcvsysgllcqfnekrvldkWINlkvslssCLCVS--DELIFCGCTDGIVRIFQAHSLLYL 328
Cdd:COG2319    290 ---------------------------------------GVN-------SVAFSpdGKLLASGSDDGTVRLWDLATGKLL 323

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257907477  329 TNLpKPHYLGVDvahgldssflfhrkaeavypdtvALTFDPVHQWLSCVYKDHSIYIWDVKDIDEVSKIWSelfHSSFVW 408
Cdd:COG2319    324 RTL-TGHTGAVR-----------------------SVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTG---HTGAVT 376

                          330       340       350
                   ....*....|....*....|....*....|....*..
gi 2257907477  409 NVevypefedqrACLPSGTFL-TCSSDNTIRFWNLDS 444
Cdd:COG2319    377 SV----------AFSPDGRTLaSGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
2-518 1.45e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 102.30  E-value: 1.45e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257907477    2 AALAAGGYTRSDTIEKLSSVMAGVPARRNQSSPPPAPPLCLRRRTRLAAAPEDTVQNRVTLEKVLGITAQNSSGLTCDPG 81
Cdd:COG2319     11 AASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDG 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257907477   82 TGHVAYLAGCVVVVLNPKENKQQHIFNTTRKSLSALAFSPDGKYIVTGENGHRpaVRIWDVEEKTQVAEMLGHKYGVACV 161
Cdd:COG2319     91 RLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGT--VRLWDLATGKLLRTLTGHSGAVTSV 168

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257907477  162 AFSPNMKHIVSMGYqhDMVLNVWDWKKDIVVAS-NKVSCRVIALSFSEDSSYFVTVG-NRHVRFWFLEASTEAKVtstvp 239
Cdd:COG2319    169 AFSPDGKLLASGSD--DGTVRLWDLATGKLLRTlTGHTGAVRSVAFSPDGKLLASGSaDGTVRLWDLATGKLLRT----- 241

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257907477  240 LVGRSGILgelhnnifcgvacgrgrmagntFCVSYSGllcqfnekrvldkwinlkvslssclcvSDELIFCGCTDGIVRI 319
Cdd:COG2319    242 LTGHSGSV----------------------RSVAFSP---------------------------DGRLLASGSADGTVRL 272

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257907477  320 FqahsllyltnlpkphylgvDVAHGLDSSFLFHRKAeAVYpdtvALTFDPVHQWLSCVYKDHSIYIWDVKDIDEVSKIWS 399
Cdd:COG2319    273 W-------------------DLATGELLRTLTGHSG-GVN----SVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTG 328

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257907477  400 elfHSSFVWNVevypefedqrACLPSGTFL-TCSSDNTIRFWNLdsasDTRWQKNIFSdsllkvvyvendiQHlqdlshf 478
Cdd:COG2319    329 ---HTGAVRSV----------AFSPDGKTLaSGSDDGTVRLWDL----ATGELLRTLT-------------GH------- 371

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|
gi 2257907477  479 pdrgsengtpmdmKAGVRVMQVSPDGQHLASGDRSGNLRI 518
Cdd:COG2319    372 -------------TGAVTSVAFSPDGRTLASGSADGTVRL 398
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 111-441 1.85e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 99.33  E-value: 1.85e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257907477  111 RKSLSALAFSPDGKYIVTG-ENGHrpaVRIWDVEEKTQVAEMLGHKYGVACVAFSPNMKHIVSMGYqhDMVLNVWDWKKD 189
Cdd:cd00200      9 TGGVTCVAFSPDGKLLATGsGDGT---IKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSS--DKTIRLWDLETG 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257907477  190 IVVAS-NKVSCRVIALSFSEDSSYFVTVG-NRHVRFWFLEASTEAKVTSTvplvgrsgilgelHNN-IFCGVACGRGRMA 266
Cdd:cd00200     84 ECVRTlTGHTSYVSSVAFSPDGRILSSSSrDKTIKVWDVETGKCLTTLRG-------------HTDwVNSVAFSPDGTFV 150

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257907477  267 gntFCVSYSGL-----LCQFNEKRVL---DKWINlkvslssCLCVSD--ELIFCGCTDGIVRIFqahsllyltNLPKPHY 336
Cdd:cd00200    151 ---ASSSQDGTiklwdLRTGKCVATLtghTGEVN-------SVAFSPdgEKLLSSSSDGTIKLW---------DLSTGKC 211

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257907477  337 LGVDVAHGldssflfhrkaEAVYpdtvALTFDPVHQWLSCVYKDHSIYIWDVKDIDEVSKIWSelfHSSFVWNVevypef 416
Cdd:cd00200    212 LGTLRGHE-----------NGVN----SVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSG---HTNSVTSL------ 267

                          330       340
                   ....*....|....*....|....*.
gi 2257907477  417 edqrACLPSGTFL-TCSSDNTIRFWN 441
Cdd:cd00200    268 ----AWSPDGKRLaSGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 299-605 1.26e-18

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 88.16  E-value: 1.26e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257907477  299 SCLCVSD--ELIFCGCTDGIVRIFQAHSLLYLTNLpKPHYLGV-DVAHGLDSSFLF------------------------ 351
Cdd:cd00200     13 TCVAFSPdgKLLATGSGDGTIKVWDLETGELLRTL-KGHTGPVrDVAASADGTYLAsgssdktirlwdletgecvrtltg 91

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257907477  352 HRKAeaVYpdtvALTFDPVHQWLSCVYKDHSIYIWDVKDIDEVSKIwseLFHSSFVWNVEVypefedqracLPSGTFLTC 431
Cdd:cd00200     92 HTSY--VS----SVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTL---RGHTDWVNSVAF----------SPDGTFVAS 152

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257907477  432 SS-DNTIRFWNLDSasdtrwqknifsdsllkvvyvendiqhlqdlshfpdrGSENGTPMDMKAGVRVMQVSPDGQHLASG 510
Cdd:cd00200    153 SSqDGTIKLWDLRT-------------------------------------GKCVATLTGHTGEVNSVAFSPDGEKLLSS 195

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257907477  511 DRSGNLRIHELHfMDELIKV-EAHDAEVLCLEYSKPEtgvTLLASASRDRLIHVLNVEKNYNLeQTLDDHSSSITAIKFA 589
Cdd:cd00200    196 SSDGTIKLWDLS-TGKCLGTlRGHENGVNSVAFSPDG---YLLASGSEDGTIRVWDLRTGECV-QTLSGHTNSVTSLAWS 270

                          330
                   ....*....|....*.
gi 2257907477  590 GTRDVqMISCGADKSI 605
Cdd:cd00200    271 PDGKR-LASGSADGTI 285
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 153-563 1.08e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 82.38  E-value: 1.08e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257907477  153 GHKYGVACVAFSPNMKHIVSMGYqhDMVLNVWDWKKDIVVASNKV-SCRVIALSFSEDSSYFVTVG-NRHVRFWFLEASt 230
Cdd:cd00200      7 GHTGGVTCVAFSPDGKLLATGSG--DGTIKVWDLETGELLRTLKGhTGPVRDVAASADGTYLASGSsDKTIRLWDLETG- 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257907477  231 eaKVTSTvpLVGrsgilgelHNnifcgvacgrgrmaGNTFCVSYSgllcqfnekrvldkwinlkvslssclcVSDELIFC 310
Cdd:cd00200     84 --ECVRT--LTG--------HT--------------SYVSSVAFS---------------------------PDGRILSS 110

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257907477  311 GCTDGIVRIFQAHSLLYLTnlpkphylgvdvahgldsSFLFHRKaeavypDTVALTFDPVHQWLSCVYKDHSIYIWDVKD 390
Cdd:cd00200    111 SSRDKTIKVWDVETGKCLT------------------TLRGHTD------WVNSVAFSPDGTFVASSSQDGTIKLWDLRT 166

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257907477  391 IdevSKIWSELFHSSFVWNVEVYPEfedqraclpSGTFLTCSSDNTIRFWNLDSAsdtrwqknifsdsllkvvyvendiQ 470
Cdd:cd00200    167 G---KCVATLTGHTGEVNSVAFSPD---------GEKLLSSSSDGTIKLWDLSTG------------------------K 210

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257907477  471 HLQDLshfpdRGSENgtpmdmkaGVRVMQVSPDGQHLASGDRSGNLRIHELHFMDELIKVEAHDAEVLCLEYSkPETGVt 550
Cdd:cd00200    211 CLGTL-----RGHEN--------GVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWS-PDGKR- 275

                          410
                   ....*....|...
gi 2257907477  551 lLASASRDRLIHV 563
Cdd:cd00200    276 -LASGSADGTIRI 287
WD40 COG2319
WD40 repeat [General function prediction only];
480-750 1.08e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 78.03  E-value: 1.08e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257907477  480 DRGSENGTPMDMKAGVRVMQVSPDGQHLASGDRSGNLRIHELHFMDELIKVEAHDAEVLCLEYSkpeTGVTLLASASRDR 559
Cdd:COG2319     24 ALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFS---PDGRLLASASADG 100

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257907477  560 LIHVLNVEKNYNLeQTLDDHSSSITAIKFAgtrdvqmiscgadksiyfrsaqqaSDGlhfvrthhvaekttlydmdidit 639
Cdd:COG2319    101 TVRLWDLATGLLL-RTLTGHTGAVRSVAFS------------------------PDG----------------------- 132

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257907477  640 qKYVAVACQDRNVRVYNTVSGKQKKCYKGSQGDEGSllkVHVDPSGTFLATSCSDKSISLIDFYSGECVAKMFGHSEIVT 719
Cdd:COG2319    133 -KTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTS---VAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVR 208

                          250       260       270
                   ....*....|....*....|....*....|...
gi 2257907477  720 GMKFTYDCRHLITVSGDSCVFIWHL--GPEITT 750
Cdd:COG2319    209 SVAFSPDGKLLASGSADGTVRLWDLatGKLLRT 241
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 632-755 1.46e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 70.06  E-value: 1.46e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257907477  632 YDMDIDITQKYVAVACQDRNVRVYNTVSGKQKKCYKGSqgdEGSLLKVHVDPSGTFLATSCSDKSISLIDFYSGECVAKM 711
Cdd:cd00200     13 TCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGH---TGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTL 89

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 2257907477  712 FGHSEIVTGMKFTYDCRHLITVSGDSCVFIWHL-GPEITTCMKQH 755
Cdd:cd00200     90 TGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVeTGKCLTTLRGH 134
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 87-224 1.59e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 70.06  E-value: 1.59e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257907477   87 YLAGC----VVVVLNPKENKQQHIFNTTRKSLSALAFSPDGKYIVTGENGHrpAVRIWDVEEKTQVAEMLGHKYGVACVA 162
Cdd:cd00200    107 ILSSSsrdkTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDG--TIKLWDLRTGKCVATLTGHTGEVNSVA 184

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2257907477  163 FSPNMKHIVSMGyqHDMVLNVWDWKKDIVVASNKVSC-RVIALSFSEDSSYFVTVG-NRHVRFW 224
Cdd:cd00200    185 FSPDGEKLLSSS--SDGTIKLWDLSTGKCLGTLRGHEnGVNSVAFSPDGYLLASGSeDGTIRVW 246
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 983-1447 6.02e-06

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 51.31  E-value: 6.02e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257907477  983 EETEAGPEDQQGDTYLRVSSVSS-KDQSPPEDSGESEAELECS---FAAAHSSAPQTDPGPHLTMTAEYPsTEELSQPEL 1058
Cdd:pfam03154  128 DEGSSDPKDIDQDNRSTSPSIPSpQDNESDSDSSAQQQILQTQppvLQAQSGAASPPSPPPPGTTQAATA-GPTPSAPSV 206

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257907477 1059 PGLGNGSLPQTPEQEKflrhhfetltdapteelfhGSLGDIKISETEDYFFNPRLSISTqflSRLQKTSRCPPrlPLHLM 1138
Cdd:pfam03154  207 PPQGSPATSQPPNQTQ-------------------STAAPHTLIQQTPTLHPQRLPSPH---PPLQPMTQPPP--PSQVS 262

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257907477 1139 KSPEAQPVGQGGNQPKAGPLRAGTGYMSSDGTNVLSGQKAEETQEALslldrkPPTPTSVLTTGREQSISAPSSCSYLES 1218
Cdd:pfam03154  263 PQPLPQPSLHGQMPPMPHSLQTGPSHMQHPVPPQPFPLTPQSSQSQV------PPGPSPAAPGQSQQRIHTPPSQSQLQS 336

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257907477 1219 -------------TTSSHAKTTRSISLGDSEGPVTAELPQSLHKPlSPGQELQAIPTTVALT--SSIKDHEPAplswgnh 1283
Cdd:pfam03154  337 qqppreqplppapLSMPHIKPPPTTPIPQLPNPQSHKHPPHLSGP-SPFQMNSNLPPPPALKplSSLSTHHPP------- 408

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257907477 1284 eARASLKLTLSSVCEQLLSPPPQEPPITHVWSQEP--VDVPPSMAVTVASFCAPSP-----VDMSTLGLHSSMFLPKTSA 1356
Cdd:pfam03154  409 -SAHPPPLQLMPQSQQLPPPPAQPPVLTQSQSLPPpaASHPPTSGLHQVPSQSPFPqhpfvPGGPPPITPPSGPPTSTSS 487

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257907477 1357 SGPLTPPAHLQLLETRSRVPGSTAALLEPT------PDASGVIADSPGHWDTEVPTPELlgsVESVLHRLQTA-FQEAL- 1428
Cdd:pfam03154  488 AMPGIQPPSSASVSSSGPVPAAVSCPLPPVqikeeaLDEAEEPESPPPPPRSPSPEPTV---VNTPSHASQSArFYKHLd 564

                          490       500
                   ....*....|....*....|....*...
gi 2257907477 1429 ---------DLYRMLVSSSQLGPEQQQA 1447
Cdd:pfam03154  565 rgynscartDLYFMPLAGSKLAKKREEA 592
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 704-743 2.92e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.68  E-value: 2.92e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 2257907477   704 SGECVAKMFGHSEIVTGMKFTYDCRHLITVSGDSCVFIWH 743
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
705-742 1.88e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.02  E-value: 1.88e-04
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2257907477  705 GECVAKMFGHSEIVTGMKFTYDCRHLITVSGDSCVFIW 742
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 634-726 3.28e-04

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 41.11  E-value: 3.28e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2257907477  634 MDIditqkyVAVACQDRNVRVYNTvSGKqkKCYKGSQGDEGSLLK-VHVDPSGTFLATSCSDKSISLIDFYSGECVAKMF 712
Cdd:pfam12894    7 MDL------IALATEDGELLLHRL-NWQ--RVWTLSPDKEDLEVTsLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFS 77

                           90
                   ....*....|....
gi 2257907477  713 GHSEIVTGMKFTYD 726
Cdd:pfam12894   78 AGSDLITCLGWGEN 91
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 117-170 4.15e-03

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 41.95  E-value: 4.15e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2257907477  117 LAFSPDGKYIV---TGENGHRpAVRIWDVEEK--TQVAEmlgHKYGVACVAFSPNMKHI 170
Cdd:COG4946    437 LAWSPDSKWLAyskPGPNQLS-QIFLYDVETGktVQLTD---GRYDDGSPAFSPDGKYL 491
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 145-185 4.37e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.52  E-value: 4.37e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 2257907477   145 KTQVAEMLGHKYGVACVAFSPNMKHIVSMGYqhDMVLNVWD 185
Cdd:smart00320    2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSD--DGTIKLWD 40
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 713-761 6.07e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 40.40  E-value: 6.07e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 2257907477  713 GHSEIVTGMKFTYDCRHLITVSGDSCVFIWHL-GPEITTCMKQHLLEINH 761
Cdd:cd00200      7 GHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLeTGELLRTLKGHTGPVRD 56
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 102-141 9.33e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.37  E-value: 9.33e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 2257907477   102 KQQHIFNTTRKSLSALAFSPDGKYIVTG-ENGHrpaVRIWD 141
Cdd:smart00320    3 ELLKTLKGHTGPVTSVAFSPDGKYLASGsDDGT---IKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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