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Conserved domains on  [gi|2255446603|ref|NP_001395482|]
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transcription factor Dp-2 isoform 15 [Mus musculus]

Protein Classification

E2F/DP family transcription factor( domain architecture ID 11180313)

E2F/DP family transcription factor can stimulate E2F-dependent transcription; it binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3'

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DP pfam08781
Transcription factor DP; DP forms a heterodimer with E2F and regulates genes involved in cell ...
 175-305 2.06e-73

Transcription factor DP; DP forms a heterodimer with E2F and regulates genes involved in cell cycle progression. The transcriptional activity of E2F is inhibited by the retinoblastoma protein which binds to the E2F-DP heterodimer and negatively regulates the G1-S transition.


:

Pssm-ID: 462601  Cd Length: 138  Bit Score: 225.16  E-value: 2.06e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2255446603 175 EKQRRIERIKQKRAQLQELLLQQIAFKNLVQRNRQNEQQNqGPPAVNSTIQLPFIIINTSRKTVIDCSISSDKFEYLFNF 254
Cdd:pfam08781   9 EKEKRLERIKKKKAQLQELILQQVAFKNLVQRNRELEQKG-GPPSPNSAIQLPFIIVNTSKKTVIDCSISNDKSEYLFNF 87

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2255446603 255 DNTFEIHDDIEVLKRMGMSFGLESGKCSLEDLKIAKSLVPKALEGYITDIS 305
Cdd:pfam08781  88 DNTFEIHDDIEVLKRMGLALGLENGECTDEDLEKAKSLVPKALEPYVDEMA 138
 
Name Accession Description Interval E-value
DP pfam08781
Transcription factor DP; DP forms a heterodimer with E2F and regulates genes involved in cell ...
 175-305 2.06e-73

Transcription factor DP; DP forms a heterodimer with E2F and regulates genes involved in cell cycle progression. The transcriptional activity of E2F is inhibited by the retinoblastoma protein which binds to the E2F-DP heterodimer and negatively regulates the G1-S transition.


Pssm-ID: 462601  Cd Length: 138  Bit Score: 225.16  E-value: 2.06e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2255446603 175 EKQRRIERIKQKRAQLQELLLQQIAFKNLVQRNRQNEQQNqGPPAVNSTIQLPFIIINTSRKTVIDCSISSDKFEYLFNF 254
Cdd:pfam08781   9 EKEKRLERIKKKKAQLQELILQQVAFKNLVQRNRELEQKG-GPPSPNSAIQLPFIIVNTSKKTVIDCSISNDKSEYLFNF 87

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2255446603 255 DNTFEIHDDIEVLKRMGMSFGLESGKCSLEDLKIAKSLVPKALEGYITDIS 305
Cdd:pfam08781  88 DNTFEIHDDIEVLKRMGLALGLENGECTDEDLEKAKSLVPKALEPYVDEMA 138
DP_DD cd14458
Dimerization domain of DP; DP functions as a binding partner for E2F transcription factors. DP ...
 175-270 1.95e-47

Dimerization domain of DP; DP functions as a binding partner for E2F transcription factors. DP and E2F form heterodimers and play important roles in regulating genes involved in DNA synthesis, cell cycle progression, proliferation and apoptosis. The transcriptional activity of E2F is inhibited by the retinoblastoma protein (Rb) which binds to the E2F-DP heterodimer, blocks the transactivation domain, and negatively regulates the G1-S transition. DP is distantly related to E2F. In humans, there are at least six closely related E2F and two DP family members, all containing a DNA binding domain, a coiled-coil (CC) region, and a marked-box domain. E2F1 to E2F5 also contain a C-terminal transactivation domain.


Pssm-ID: 271217  Cd Length: 105  Bit Score: 157.35  E-value: 1.95e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2255446603 175 EKQRRIERIKQKRAQLQELLLQQIAFKNLVQRNRQNEQQNQGPPAvNSTIQLPFIIINTSRKTVIDCSISSDKFEYLFNF 254
Cdd:cd14458    11 EKERRRERIEKKKAQLQELILQQIALKNLVERNREREAQGEAPAP-NSKIQLPFIIVNTSKDAVIDCEISEDRSEYLFNF 89

                          90
                  ....*....|....*.
gi 2255446603 255 DNTFEIHDDIEVLKRM 270
Cdd:cd14458    90 NSPFEIHDDIEILKRM 105
 
Name Accession Description Interval E-value
DP pfam08781
Transcription factor DP; DP forms a heterodimer with E2F and regulates genes involved in cell ...
 175-305 2.06e-73

Transcription factor DP; DP forms a heterodimer with E2F and regulates genes involved in cell cycle progression. The transcriptional activity of E2F is inhibited by the retinoblastoma protein which binds to the E2F-DP heterodimer and negatively regulates the G1-S transition.


Pssm-ID: 462601  Cd Length: 138  Bit Score: 225.16  E-value: 2.06e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2255446603 175 EKQRRIERIKQKRAQLQELLLQQIAFKNLVQRNRQNEQQNqGPPAVNSTIQLPFIIINTSRKTVIDCSISSDKFEYLFNF 254
Cdd:pfam08781   9 EKEKRLERIKKKKAQLQELILQQVAFKNLVQRNRELEQKG-GPPSPNSAIQLPFIIVNTSKKTVIDCSISNDKSEYLFNF 87

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2255446603 255 DNTFEIHDDIEVLKRMGMSFGLESGKCSLEDLKIAKSLVPKALEGYITDIS 305
Cdd:pfam08781  88 DNTFEIHDDIEVLKRMGLALGLENGECTDEDLEKAKSLVPKALEPYVDEMA 138
DP_DD cd14458
Dimerization domain of DP; DP functions as a binding partner for E2F transcription factors. DP ...
 175-270 1.95e-47

Dimerization domain of DP; DP functions as a binding partner for E2F transcription factors. DP and E2F form heterodimers and play important roles in regulating genes involved in DNA synthesis, cell cycle progression, proliferation and apoptosis. The transcriptional activity of E2F is inhibited by the retinoblastoma protein (Rb) which binds to the E2F-DP heterodimer, blocks the transactivation domain, and negatively regulates the G1-S transition. DP is distantly related to E2F. In humans, there are at least six closely related E2F and two DP family members, all containing a DNA binding domain, a coiled-coil (CC) region, and a marked-box domain. E2F1 to E2F5 also contain a C-terminal transactivation domain.


Pssm-ID: 271217  Cd Length: 105  Bit Score: 157.35  E-value: 1.95e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2255446603 175 EKQRRIERIKQKRAQLQELLLQQIAFKNLVQRNRQNEQQNQGPPAvNSTIQLPFIIINTSRKTVIDCSISSDKFEYLFNF 254
Cdd:cd14458    11 EKERRRERIEKKKAQLQELILQQIALKNLVERNREREAQGEAPAP-NSKIQLPFIIVNTSKDAVIDCEISEDRSEYLFNF 89

                          90
                  ....*....|....*.
gi 2255446603 255 DNTFEIHDDIEVLKRM 270
Cdd:cd14458    90 NSPFEIHDDIEILKRM 105
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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