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Conserved domains on  [gi|2215162867|ref|NP_001390515|]
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WD repeat-containing protein 26 isoform 7 [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 10652957)

WD40 repeat domain-containing protein with a CTLH (C-terminal to LisH) motif, similar to human WD repeat-containing protein 26 (WDR26), a Gbeta-like protein that suppresses MAPK signaling pathways

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
184-478 1.74e-50

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 177.41  E-value: 1.74e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2215162867 184 TQQILTEHCNEVWFCKFSNDGTKLATGSKDTTVIIWqvdpDTHLLKLLKTLEGHAYGVSYIAWSPDDSYLVACGPDDcsE 263
Cdd:COG2319   112 LLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLW----DLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDG--T 185

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2215162867 264 LWLWNVQTGELRTKMsQSHEDSLTSVAWNPDGKRFVTGGQRGQFYQCDLD-GNLLDSWEG--VRVQCLWCLSDGKTVLAS 340
Cdd:COG2319   186 VRLWDLATGKLLRTL-TGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLAtGKLLRTLTGhsGSVRSVAFSPDGRLLASG 264

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2215162867 341 DTHQRVRGYnfeDLTDRNIVQ----EDHPIMSFTISKNGRLALLNVATQGVHLWDLQDRVLVRKYQGVTQGFYTIhsCFG 416
Cdd:COG2319   265 SADGTVRLW---DLATGELLRtltgHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV--AFS 339

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2215162867 417 gHNEDFIASGSEDHKVYIWHKRSELPIAELTGHTRTVNCVSWNPQiPSMMASASDDGTVRIW 478
Cdd:COG2319   340 -PDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPD-GRTLASGSADGTVRLW 399
CTLH smart00668
C-terminal to LisH motif; Alpha-helical motif of unknown function.
 9-68 3.13e-07

C-terminal to LisH motif; Alpha-helical motif of unknown function.


:

Pssm-ID: 128914  Cd Length: 58  Bit Score: 47.18  E-value: 3.13e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2215162867    9 EHPSATKFRNHVMEGDWDKAENDLNELKPLVHSPHAivRMKFLLLQQKYLEYLEDGKVLE 68
Cdd:smart00668   1 EFDERKRIRELILKGDWDEALEWLSSLKPPLLERNS--KLEFELRKQKFLELVRQGKLEE 58
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
184-478 1.74e-50

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 177.41  E-value: 1.74e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2215162867 184 TQQILTEHCNEVWFCKFSNDGTKLATGSKDTTVIIWqvdpDTHLLKLLKTLEGHAYGVSYIAWSPDDSYLVACGPDDcsE 263
Cdd:COG2319   112 LLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLW----DLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDG--T 185

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2215162867 264 LWLWNVQTGELRTKMsQSHEDSLTSVAWNPDGKRFVTGGQRGQFYQCDLD-GNLLDSWEG--VRVQCLWCLSDGKTVLAS 340
Cdd:COG2319   186 VRLWDLATGKLLRTL-TGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLAtGKLLRTLTGhsGSVRSVAFSPDGRLLASG 264

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2215162867 341 DTHQRVRGYnfeDLTDRNIVQ----EDHPIMSFTISKNGRLALLNVATQGVHLWDLQDRVLVRKYQGVTQGFYTIhsCFG 416
Cdd:COG2319   265 SADGTVRLW---DLATGELLRtltgHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV--AFS 339

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2215162867 417 gHNEDFIASGSEDHKVYIWHKRSELPIAELTGHTRTVNCVSWNPQiPSMMASASDDGTVRIW 478
Cdd:COG2319   340 -PDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPD-GRTLASGSADGTVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 186-478 1.78e-43

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 155.19  E-value: 1.78e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2215162867 186 QILTEHCNEVWFCKFSNDGTKLATGSKDTTVIIWQVDPDTHLLKLlktlEGHAYGVSYIAWSPDDSYLVACGPDDCseLW 265
Cdd:cd00200     3 RTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTL----KGHTGPVRDVAASADGTYLASGSSDKT--IR 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2215162867 266 LWNVQTGELRTKMSQsHEDSLTSVAWNPDGKRFVTGGQrgqfyqcdlDGNLLdSWEGVRVQCL----------WCLS--- 332
Cdd:cd00200    77 LWDLETGECVRTLTG-HTSYVSSVAFSPDGRILSSSSR---------DKTIK-VWDVETGKCLttlrghtdwvNSVAfsp 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2215162867 333 DGKTVLASDTHQRVRGYNFEDL-TDRNIVQEDHPIMSFTISKNGRLALLNVATQGVHLWDLQDRVLVRKYQGVTQGFYTI 411
Cdd:cd00200   146 DGTFVASSSQDGTIKLWDLRTGkCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSV 225

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2215162867 412 hsCFGGHNeDFIASGSEDHKVYIWHKRSELPIAELTGHTRTVNCVSWNPQIPsMMASASDDGTVRIW 478
Cdd:cd00200   226 --AFSPDG-YLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGK-RLASGSADGTIRIW 288
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 442-478 7.27e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.46  E-value: 7.27e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2215162867  442 PIAELTGHTRTVNCVSWNPQiPSMMASASDDGTVRIW 478
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPD-GKYLASGSDDGTIKLW 39
CTLH smart00668
C-terminal to LisH motif; Alpha-helical motif of unknown function.
 9-68 3.13e-07

C-terminal to LisH motif; Alpha-helical motif of unknown function.


Pssm-ID: 128914  Cd Length: 58  Bit Score: 47.18  E-value: 3.13e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2215162867    9 EHPSATKFRNHVMEGDWDKAENDLNELKPLVHSPHAivRMKFLLLQQKYLEYLEDGKVLE 68
Cdd:smart00668   1 EFDERKRIRELILKGDWDEALEWLSSLKPPLLERNS--KLEFELRKQKFLELVRQGKLEE 58
WD40 pfam00400
WD domain, G-beta repeat;
442-478 4.52e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.18  E-value: 4.52e-07
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 2215162867 442 PIAELTGHTRTVNCVSWNPQiPSMMASASDDGTVRIW 478
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPD-GKLLASGSDDGTVKVW 38
PTZ00420 PTZ00420
coronin; Provisional
 414-478 4.51e-06

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 49.18  E-value: 4.51e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2215162867 414 CFgghnEDFIASGSEDHKVYIWHKRSEL--------PIAELTGHTRTVNCVSWNPQIPSMMASASDDGTVRIW 478
Cdd:PTZ00420   85 CF----SEILASGSEDLTIRVWEIPHNDesvkeikdPQCILKGHKKKISIIDWNPMNYYIMCSSGFDSFVNIW 153
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
184-478 1.74e-50

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 177.41  E-value: 1.74e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2215162867 184 TQQILTEHCNEVWFCKFSNDGTKLATGSKDTTVIIWqvdpDTHLLKLLKTLEGHAYGVSYIAWSPDDSYLVACGPDDcsE 263
Cdd:COG2319   112 LLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLW----DLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDG--T 185

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2215162867 264 LWLWNVQTGELRTKMsQSHEDSLTSVAWNPDGKRFVTGGQRGQFYQCDLD-GNLLDSWEG--VRVQCLWCLSDGKTVLAS 340
Cdd:COG2319   186 VRLWDLATGKLLRTL-TGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLAtGKLLRTLTGhsGSVRSVAFSPDGRLLASG 264

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2215162867 341 DTHQRVRGYnfeDLTDRNIVQ----EDHPIMSFTISKNGRLALLNVATQGVHLWDLQDRVLVRKYQGVTQGFYTIhsCFG 416
Cdd:COG2319   265 SADGTVRLW---DLATGELLRtltgHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV--AFS 339

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2215162867 417 gHNEDFIASGSEDHKVYIWHKRSELPIAELTGHTRTVNCVSWNPQiPSMMASASDDGTVRIW 478
Cdd:COG2319   340 -PDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPD-GRTLASGSADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
185-478 1.16e-47

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 169.71  E-value: 1.16e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2215162867 185 QQILTEHCNEVWFCKFSNDGTKLATGSKDTTVIIWQVDPdthlLKLLKTLEGHAYGVSYIAWSPDDSYLVACGPDDcsEL 264
Cdd:COG2319    71 LATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLAT----GLLLRTLTGHTGAVRSVAFSPDGKTLASGSADG--TV 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2215162867 265 WLWNVQTGELRTKMSqSHEDSLTSVAWNPDGKRFVTGGQRGQFYQCDLD-GNLLDSWEG--VRVQCLWCLSDGKTVLASD 341
Cdd:COG2319   145 RLWDLATGKLLRTLT-GHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLAtGKLLRTLTGhtGAVRSVAFSPDGKLLASGS 223

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2215162867 342 THQRVRGYnfeDLTDRNIVQE----DHPIMSFTISKNGRLALLNVATQGVHLWDLQDRVLVRKYQGVTQGFYTIhsCFGG 417
Cdd:COG2319   224 ADGTVRLW---DLATGKLLRTltghSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSV--AFSP 298

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2215162867 418 hNEDFIASGSEDHKVYIWHKRSELPIAELTGHTRTVNCVSWNPQiPSMMASASDDGTVRIW 478
Cdd:COG2319   299 -DGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPD-GKTLASGSDDGTVRLW 357
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 186-478 1.78e-43

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 155.19  E-value: 1.78e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2215162867 186 QILTEHCNEVWFCKFSNDGTKLATGSKDTTVIIWQVDPDTHLLKLlktlEGHAYGVSYIAWSPDDSYLVACGPDDCseLW 265
Cdd:cd00200     3 RTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTL----KGHTGPVRDVAASADGTYLASGSSDKT--IR 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2215162867 266 LWNVQTGELRTKMSQsHEDSLTSVAWNPDGKRFVTGGQrgqfyqcdlDGNLLdSWEGVRVQCL----------WCLS--- 332
Cdd:cd00200    77 LWDLETGECVRTLTG-HTSYVSSVAFSPDGRILSSSSR---------DKTIK-VWDVETGKCLttlrghtdwvNSVAfsp 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2215162867 333 DGKTVLASDTHQRVRGYNFEDL-TDRNIVQEDHPIMSFTISKNGRLALLNVATQGVHLWDLQDRVLVRKYQGVTQGFYTI 411
Cdd:cd00200   146 DGTFVASSSQDGTIKLWDLRTGkCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSV 225

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2215162867 412 hsCFGGHNeDFIASGSEDHKVYIWHKRSELPIAELTGHTRTVNCVSWNPQIPsMMASASDDGTVRIW 478
Cdd:cd00200   226 --AFSPDG-YLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGK-RLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
188-478 1.03e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 103.07  E-value: 1.03e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2215162867 188 LTEHCNEVWFCKFSNDGTKLATGSKDTTVIIWqvdpDTHLLKLLKTLEGHAYGVSYIAWSPDDSYLVACGPDdcSELWLW 267
Cdd:COG2319    32 LLGLAAAVASLAASPDGARLAAGAGDLTLLLL----DAAAGALLATLLGHTAAVLSVAFSPDGRLLASASAD--GTVRLW 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2215162867 268 NVQTGELRTKmSQSHEDSLTSVAWNPDGKRFVTGgqrgqfyqcdldgnlldswegvrvqclwclSDGKTVlasdthqrvr 347
Cdd:COG2319   106 DLATGLLLRT-LTGHTGAVRSVAFSPDGKTLASG------------------------------SADGTV---------- 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2215162867 348 gynfedltdrnivqedhpimsftiskngrlallnvatqgvHLWDLQDRVLVRKYQGVTQGFYTIhsCFGgHNEDFIASGS 427
Cdd:COG2319   145 ----------------------------------------RLWDLATGKLLRTLTGHSGAVTSV--AFS-PDGKLLASGS 181

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2215162867 428 EDHKVYIWHKRSELPIAELTGHTRTVNCVSWNPQiPSMMASASDDGTVRIW 478
Cdd:COG2319   182 DDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPD-GKLLASGSADGTVRLW 231
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 182-303 7.76e-19

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 86.62  E-value: 7.76e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2215162867 182 CYTQQILTEHCNEVWFCKFSNDGTKLATGSKDTTVIIWqvdpDTHLLKLLKTLEGHAYGVSYIAWSPdDSYLVACGPDDC 261
Cdd:cd00200   167 GKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLW----DLSTGKCLGTLRGHENGVNSVAFSP-DGYLLASGSEDG 241

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 2215162867 262 SeLWLWNVQTGELrTKMSQSHEDSLTSVAWNPDGKRFVTGGQ 303
Cdd:cd00200   242 T-IRVWDLRTGEC-VQTLSGHTNSVTSLAWSPDGKRLASGSA 281
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 188-315 5.78e-09

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 55.06  E-value: 5.78e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2215162867 188 LTEHCNEVWFCKFSNDGTKLA-TGSKDTTVIIWQVDPDTHLLKLLKTLEGHAYGVSyiaWSPDDSYLV-ACGPDDCSELW 265
Cdd:COG0823    26 LTNSPGIDTSPAWSPDGRRIAfTSDRGGGPQIYVVDADGGEPRRLTFGGGYNASPS---WSPDGKRLAfVSRSDGRFDIY 102

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2215162867 266 LWNVQTGELRTkmsqsHEDSLTSVAWNPDGKRFV---TGGQRGQFYQCDLDGN 315
Cdd:COG0823   103 VLDLDGGAPRR-----LTDGPGSPSWSPDGRRIVfssDRGGRPDLYVVDLDGR 150
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 442-478 7.27e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.46  E-value: 7.27e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2215162867  442 PIAELTGHTRTVNCVSWNPQiPSMMASASDDGTVRIW 478
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPD-GKYLASGSDDGTIKLW 39
CTLH smart00668
C-terminal to LisH motif; Alpha-helical motif of unknown function.
 9-68 3.13e-07

C-terminal to LisH motif; Alpha-helical motif of unknown function.


Pssm-ID: 128914  Cd Length: 58  Bit Score: 47.18  E-value: 3.13e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2215162867    9 EHPSATKFRNHVMEGDWDKAENDLNELKPLVHSPHAivRMKFLLLQQKYLEYLEDGKVLE 68
Cdd:smart00668   1 EFDERKRIRELILKGDWDEALEWLSSLKPPLLERNS--KLEFELRKQKFLELVRQGKLEE 58
WD40 pfam00400
WD domain, G-beta repeat;
442-478 4.52e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.18  E-value: 4.52e-07
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 2215162867 442 PIAELTGHTRTVNCVSWNPQiPSMMASASDDGTVRIW 478
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPD-GKLLASGSDDGTVKVW 38
PTZ00420 PTZ00420
coronin; Provisional
 414-478 4.51e-06

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 49.18  E-value: 4.51e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2215162867 414 CFgghnEDFIASGSEDHKVYIWHKRSEL--------PIAELTGHTRTVNCVSWNPQIPSMMASASDDGTVRIW 478
Cdd:PTZ00420   85 CF----SEILASGSEDLTIRVWEIPHNDesvkeikdPQCILKGHKKKISIIDWNPMNYYIMCSSGFDSFVNIW 153
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 186-219 1.91e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.53  E-value: 1.91e-05
                           10        20        30
                   ....*....|....*....|....*....|....
gi 2215162867  186 QILTEHCNEVWFCKFSNDGTKLATGSKDTTVIIW 219
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 COG2319
WD40 repeat [General function prediction only];
186-222 2.44e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 46.44  E-value: 2.44e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 2215162867 186 QILTEHCNEVWFCKFSNDGTKLATGSKDTTVIIWQVD 222
Cdd:COG2319   366 RTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 pfam00400
WD domain, G-beta repeat;
185-219 5.71e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.41  E-value: 5.71e-05
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 2215162867 185 QQILTEHCNEVWFCKFSNDGTKLATGSKDTTVIIW 219
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 423-478 6.45e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 45.85  E-value: 6.45e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2215162867 423 IASGSEDHKVYIWHKRS-ELPIAELTGHTRTVNCVSWNPQipSMMASASDDGTVRIW 478
Cdd:PLN00181  633 LAFGSADHKVYYYDLRNpKLPLCTMIGHSKTVSYVRFVDS--STLVSSSTDNTLKLW 687
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 442-478 1.05e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 44.25  E-value: 1.05e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 2215162867 442 PIAELTGHTRTVNCVSWNPQiPSMMASASDDGTVRIW 478
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPD-GKLLATGSGDGTIKVW 36
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 414-478 1.96e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 43.92  E-value: 1.96e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2215162867 414 CFGGHNEDFIASGSEDHKVYIWH-KRSELpIAELTGHTRTVNCVSWNPQIPSMMASASDDGTVRIW 478
Cdd:PLN00181  539 CWNSYIKSQVASSNFEGVVQVWDvARSQL-VTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLW 603
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 199-296 2.56e-04

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 43.87  E-value: 2.56e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2215162867  199 KFSNDGTKLATGSKDTTviIW----------QVDPDthllkllktleGHAYGVSYIAWSPDDSYLV--ACGPDDCSELWL 266
Cdd:COG4946    395 VWSPDGKKIAFTDNRGR--LWvvdlasgkvrKVDTD-----------GYGDGISDLAWSPDSKWLAysKPGPNQLSQIFL 461

                           90       100       110
                   ....*....|....*....|....*....|
gi 2215162867  267 WNVQTGELrTKMSQSHEDSlTSVAWNPDGK 296
Cdd:COG4946    462 YDVETGKT-VQLTDGRYDD-GSPAFSPDGK 489
PTZ00421 PTZ00421
coronin; Provisional
 203-330 4.93e-04

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 42.57  E-value: 4.93e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2215162867 203 DGTKLATGSKDTTVIIWQVDPDTHLLKLLK---TLEGHAYGVSYIAWSPDDSYLVACGPDDcSELWLWNVQTGELRTKMS 279
Cdd:PTZ00421   87 DPQKLFTASEDGTIMGWGIPEEGLTQNISDpivHLQGHTKKVGIVSFHPSAMNVLASAGAD-MVVNVWDVERGKAVEVIK 165

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2215162867 280 qSHEDSLTSVAWNPDGKRFVTGGQRGQFYQCD-LDGNLLDSWE---GVRVQ-CLWC 330
Cdd:PTZ00421  166 -CHSDQITSLEWNLDGSLLCTTSKDKKLNIIDpRDGTIVSSVEahaSAKSQrCLWA 220
eIF2A pfam08662
Eukaryotic translation initiation factor eIF2A; This is a family of eukaryotic translation ...
 244-300 1.47e-03

Eukaryotic translation initiation factor eIF2A; This is a family of eukaryotic translation initiation factors.


Pssm-ID: 462552 [Multi-domain]  Cd Length: 194  Bit Score: 39.95  E-value: 1.47e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2215162867 244 IAWSPDDSYLVACGPDDCS-ELWLWNVQTgelRTKMSQSHEDSLTSVAWNPDGKRFVT 300
Cdd:pfam08662 106 IFWSPFGRLVLLAGFGNLAgDIEFWDVVN---KKKIATAEASNATLCEWSPDGRYFLT 160
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 200-296 2.55e-03

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 40.41  E-value: 2.55e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2215162867  200 FSNDGTKLA-----TGSKDttviIWQVDPDTHLLKLLKTLEGHAYgVSYIAWSPDDSYLVACgpDDCSELWLWNVQTGEL 274
Cdd:COG4946    350 WSPDGKSIAyfsdaSGEYE----LYIAPADGSGEPKQLTLGDLGR-VFNPVWSPDGKKIAFT--DNRGRLWVVDLASGKV 422

                           90       100
                   ....*....|....*....|..
gi 2215162867  275 RTKMSQSHEDSLTSVAWNPDGK 296
Cdd:COG4946    423 RKVDTDGYGDGISDLAWSPDSK 444
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 186-220 3.12e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 39.63  E-value: 3.12e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 2215162867 186 QILTEHCNEVWFCKFSNDGTKLATGSKDTTVIIWQ 220
Cdd:cd00200   255 QTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
PTZ00420 PTZ00420
coronin; Provisional
 442-478 4.25e-03

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 39.55  E-value: 4.25e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 2215162867 442 PIAELTGHTRTVNCVSWNPQIPSMMASASDDGTVRIW 478
Cdd:PTZ00420   66 PVIKLKGHTSSILDLQFNPCFSEILASGSEDLTIRVW 102
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 262-314 7.67e-03

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 37.34  E-value: 7.67e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2215162867 262 SELWLWNVQTGELRTKMSQSHEDslTSVAWNPDGKRFV---TGGQRGQFYQCDLDG 314
Cdd:COG0823    11 SDIYVVDLDGGEPRRLTNSPGID--TSPAWSPDGRRIAftsDRGGGPQIYVVDADG 64
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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