RNA N6-adenosine-methyltransferase METTL16 acts as a RNA N6-methyltransferase that methylates adenosine residues at the N(6) position of a subset of RNAs and is involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts
RNA methyltransferase; This family includes ribosomal RNA large subunit methyltransferase F, ...
1-291
3.03e-178
RNA methyltransferase; This family includes ribosomal RNA large subunit methyltransferase F, and related proteins, including methyltransferase-like protein 16 (METTL16). METTL16 is a conserved RNA methyltransferase which interacts specifically with the MALAT1 triple helix. METTL16 shows nuclear localization. Another functional study indicates that METTL16 regulates expression of human MAT2A, which encodes the SAM synthetase expressed in most cells. Furthermore, results indicate that METTL16 is the long-unknown methyltransferase for the U6 spliceosomal small nuclear RNA (snRNA) and it has evolved an additional function in vertebrates to control SAM homeostasis by post-transcriptionally regulating SAM synthetase gene expression.
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Pssm-ID: 399160 [Multi-domain] Cd Length: 291 Bit Score: 503.97 E-value: 3.03e-178
RNA methyltransferase; This family includes ribosomal RNA large subunit methyltransferase F, ...
1-291
3.03e-178
RNA methyltransferase; This family includes ribosomal RNA large subunit methyltransferase F, and related proteins, including methyltransferase-like protein 16 (METTL16). METTL16 is a conserved RNA methyltransferase which interacts specifically with the MALAT1 triple helix. METTL16 shows nuclear localization. Another functional study indicates that METTL16 regulates expression of human MAT2A, which encodes the SAM synthetase expressed in most cells. Furthermore, results indicate that METTL16 is the long-unknown methyltransferase for the U6 spliceosomal small nuclear RNA (snRNA) and it has evolved an additional function in vertebrates to control SAM homeostasis by post-transcriptionally regulating SAM synthetase gene expression.
Pssm-ID: 399160 [Multi-domain] Cd Length: 291 Bit Score: 503.97 E-value: 3.03e-178
23S rRNA A1618 N6-methylase RlmF [Translation, ribosomal structure and biogenesis]; 23S rRNA A1618 N6-methylase RlmF is part of the Pathway/BioSystem: 23S rRNA modification
Pssm-ID: 442363 Cd Length: 292 Bit Score: 206.56 E-value: 2.48e-62
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
105-215
1.75e-05
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).
Pssm-ID: 100107 [Multi-domain] Cd Length: 107 Bit Score: 43.96 E-value: 1.75e-05
RNA methyltransferase; This family includes ribosomal RNA large subunit methyltransferase F, ...
1-291
3.03e-178
RNA methyltransferase; This family includes ribosomal RNA large subunit methyltransferase F, and related proteins, including methyltransferase-like protein 16 (METTL16). METTL16 is a conserved RNA methyltransferase which interacts specifically with the MALAT1 triple helix. METTL16 shows nuclear localization. Another functional study indicates that METTL16 regulates expression of human MAT2A, which encodes the SAM synthetase expressed in most cells. Furthermore, results indicate that METTL16 is the long-unknown methyltransferase for the U6 spliceosomal small nuclear RNA (snRNA) and it has evolved an additional function in vertebrates to control SAM homeostasis by post-transcriptionally regulating SAM synthetase gene expression.
Pssm-ID: 399160 [Multi-domain] Cd Length: 291 Bit Score: 503.97 E-value: 3.03e-178
23S rRNA A1618 N6-methylase RlmF [Translation, ribosomal structure and biogenesis]; 23S rRNA A1618 N6-methylase RlmF is part of the Pathway/BioSystem: 23S rRNA modification
Pssm-ID: 442363 Cd Length: 292 Bit Score: 206.56 E-value: 2.48e-62
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification
Pssm-ID: 443299 [Multi-domain] Cd Length: 238 Bit Score: 49.37 E-value: 1.64e-06
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
105-215
1.75e-05
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).
Pssm-ID: 100107 [Multi-domain] Cd Length: 107 Bit Score: 43.96 E-value: 1.75e-05
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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