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Conserved domains on  [gi|2202952938|ref|NP_001388936|]
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zinc finger protein LOC728743 homolog [Mus musculus]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
37-188 4.39e-07

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 49.31  E-value: 4.39e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2202952938  37 HRCPLCGQTFSQQPSLVRHQKA--HVGAGrAAAFVCPE--CGKAFSVKHNLEVHQRTHTGERPFACPECGRCFSLKQNL- 111
Cdd:COG5048   290 IKSKQCNISFSRSSPLTRHLRSvnHSGES-LKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLn 368

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2202952938 112 ------LTHQRIHSGEKPHQCA--QCGRCFREPRFLLNHQRTHARMPTPHprrpgvfgerrpYFCPRCGKSFAREGSLKT 183
Cdd:COG5048   369 neppqsLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPYN------------CKNPPCSKSFNRHYNLIP 436


                  ....*
gi 2202952938 184 HQRSH 188
Cdd:COG5048   437 HKKIH 441
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
37-188 4.39e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 49.31  E-value: 4.39e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2202952938  37 HRCPLCGQTFSQQPSLVRHQKA--HVGAGrAAAFVCPE--CGKAFSVKHNLEVHQRTHTGERPFACPECGRCFSLKQNL- 111
Cdd:COG5048   290 IKSKQCNISFSRSSPLTRHLRSvnHSGES-LKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLn 368

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2202952938 112 ------LTHQRIHSGEKPHQCA--QCGRCFREPRFLLNHQRTHARMPTPHprrpgvfgerrpYFCPRCGKSFAREGSLKT 183
Cdd:COG5048   369 neppqsLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPYN------------CKNPPCSKSFNRHYNLIP 436


                  ....*
gi 2202952938 184 HQRSH 188
Cdd:COG5048   437 HKKIH 441
zf-H2C2_2 pfam13465
Zinc-finger double domain;
82-106 2.31e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 2.31e-04
                          10        20
                  ....*....|....*....|....*
gi 2202952938  82 NLEVHQRTHTGERPFACPECGRCFS 106
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
37-188 4.39e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 49.31  E-value: 4.39e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2202952938  37 HRCPLCGQTFSQQPSLVRHQKA--HVGAGrAAAFVCPE--CGKAFSVKHNLEVHQRTHTGERPFACPECGRCFSLKQNL- 111
Cdd:COG5048   290 IKSKQCNISFSRSSPLTRHLRSvnHSGES-LKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLn 368

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2202952938 112 ------LTHQRIHSGEKPHQCA--QCGRCFREPRFLLNHQRTHARMPTPHprrpgvfgerrpYFCPRCGKSFAREGSLKT 183
Cdd:COG5048   369 neppqsLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPYN------------CKNPPCSKSFNRHYNLIP 436


                  ....*
gi 2202952938 184 HQRSH 188
Cdd:COG5048   437 HKKIH 441
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
94-146 9.67e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.46  E-value: 9.67e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2202952938  94 RPFACPECGRCFSLKQNLLTHQRIHSGEKPHQCAQCGR--CFREPRFLLNHQRTH 146
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCdkSFSRPLELSRHLRTH 86
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 92-190 9.01e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.40  E-value: 9.01e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2202952938  92 GERPFACP--ECGRCFSlKQNLLTHQRIHsgekphqcaqcGRCfreprfllnHQRTHarmPTPHPRRPGVF-GERRPYFC 168
Cdd:COG5189   346 DGKPYKCPveGCNKKYK-NQNGLKYHMLH-----------GHQ---------NQKLH---ENPSPEKMNIFsAKDKPYRC 401

                          90       100
                  ....*....|....*....|..
gi 2202952938 169 PRCGKSFAREGSLKTHqRSHGH 190
Cdd:COG5189   402 EVCDKRYKNLNGLKYH-RKHSH 422
zf-H2C2_2 pfam13465
Zinc-finger double domain;
82-106 2.31e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 2.31e-04
                          10        20
                  ....*....|....*....|....*
gi 2202952938  82 NLEVHQRTHTGERPFACPECGRCFS 106
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
CpXC pfam14353
CpXC protein; This presumed domain is functionally uncharacterized. This domain is found in ...
 38-90 2.85e-04

CpXC protein; This presumed domain is functionally uncharacterized. This domain is found in bacteria and archaea, and is typically between 122 and 134 amino acids in length. It contains four conserved cysteines forming two CpXC motifs.


Pssm-ID: 433895  Cd Length: 121  Bit Score: 39.24  E-value: 2.85e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2202952938  38 RCPLCGQTF----------SQQPSLvrhqKAHVGAGRAAAFVCPECGKAFSVKHNLEVHQRTH 90
Cdd:pfam14353   2 TCPKCGKEFeaevwtsinaDEDPEL----KEKVLDGSLFSFTCPKCGASFRLEYPLLYHDPEK 60
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 68-90 1.26e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 1.26e-03
                          10        20
                  ....*....|....*....|...
gi 2202952938  68 FVCPECGKAFSVKHNLEVHQRTH 90
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
110-133 2.70e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 2.70e-03
                          10        20
                  ....*....|....*....|....
gi 2202952938 110 NLLTHQRIHSGEKPHQCAQCGRCF 133
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
68-131 6.09e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 36.98  E-value: 6.09e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2202952938  68 FVCPECGKAFSVKHNLEVHQRTHTGERPFACPECGR--CFSLKQNLLTHQRIHSGEKPHQCAQCGR 131
Cdd:COG5048    34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCdkSFSRPLELSRHLRTHHNNPSDLNSKSLP 99
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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