non-selective voltage-gated ion channel VDAC1 isoform 7 [Homo sapiens]
mitochondrial porin family protein( domain architecture ID 1295)
mitochondrial porin family protein is found in the outer membrane of mitochondria and is a pore-forming protein that allows ions and small molecules to pass through the membrane
List of domain hits
Name | Accession | Description | Interval | E-value | |||
Porin3 super family | cl03224 | Eukaryotic porin family that forms channels in the mitochondrial outer membrane; The porin ... |
1-154 | 1.42e-65 | |||
Eukaryotic porin family that forms channels in the mitochondrial outer membrane; The porin family 3 contains two sub-families that play vital roles in the mitochondrial outer membrane, a translocase for unfolded pre-proteins (Tom40) and the voltage-dependent anion channel (VDAC) that regulates the flux of mostly anionic metabolites through the outer mitochondrial membrane. The actual alignment was detected with superfamily member cd07303: Pssm-ID: 470762 [Multi-domain] Cd Length: 274 Bit Score: 200.96 E-value: 1.42e-65
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Name | Accession | Description | Interval | E-value | |||
Porin3 | cd07303 | Eukaryotic porin family that forms channels in the mitochondrial outer membrane; The porin ... |
1-154 | 1.42e-65 | |||
Eukaryotic porin family that forms channels in the mitochondrial outer membrane; The porin family 3 contains two sub-families that play vital roles in the mitochondrial outer membrane, a translocase for unfolded pre-proteins (Tom40) and the voltage-dependent anion channel (VDAC) that regulates the flux of mostly anionic metabolites through the outer mitochondrial membrane. Pssm-ID: 132765 [Multi-domain] Cd Length: 274 Bit Score: 200.96 E-value: 1.42e-65
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Porin_3 | pfam01459 | Eukaryotic porin; |
1-148 | 2.41e-49 | |||
Eukaryotic porin; Pssm-ID: 460220 [Multi-domain] Cd Length: 269 Bit Score: 159.30 E-value: 2.41e-49
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Name | Accession | Description | Interval | E-value | |||
Porin3 | cd07303 | Eukaryotic porin family that forms channels in the mitochondrial outer membrane; The porin ... |
1-154 | 1.42e-65 | |||
Eukaryotic porin family that forms channels in the mitochondrial outer membrane; The porin family 3 contains two sub-families that play vital roles in the mitochondrial outer membrane, a translocase for unfolded pre-proteins (Tom40) and the voltage-dependent anion channel (VDAC) that regulates the flux of mostly anionic metabolites through the outer mitochondrial membrane. Pssm-ID: 132765 [Multi-domain] Cd Length: 274 Bit Score: 200.96 E-value: 1.42e-65
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Porin3_VDAC | cd07306 | Voltage-dependent anion channel of the outer mitochondrial membrane; The voltage-dependent ... |
1-154 | 4.01e-65 | |||
Voltage-dependent anion channel of the outer mitochondrial membrane; The voltage-dependent anion channel (VDAC) regulates the flux of mostly anionic metabolites through the outer mitochondrial membrane, which is highly permeable to small molecules. VDAC is the most abundant protein in the outer membrane, and membrane potentials can toggle VDAC between open or high-conducting and closed or low-conducting forms. VDAC binds to and is regulated in part by hexokinase, an interaction that renders mitochondria less susceptible to pro-apoptotic signals, most likely by intefering with VDAC's capability to respond to Bcl-2 family proteins. While VDAC appears to play a key role in mitochondrially induced cell death, a proposed involvement in forming the mitochondrial permeability transition pore, which is characteristic for damaged mitochondria and apoptosis, has been challenged by more recent studies. Pssm-ID: 132767 [Multi-domain] Cd Length: 276 Bit Score: 199.74 E-value: 4.01e-65
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Porin_3 | pfam01459 | Eukaryotic porin; |
1-148 | 2.41e-49 | |||
Eukaryotic porin; Pssm-ID: 460220 [Multi-domain] Cd Length: 269 Bit Score: 159.30 E-value: 2.41e-49
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Porin3_Tom40 | cd07305 | Translocase of outer mitochondrial membrane 40 (Tom40); Tom40 forms a channel in the ... |
14-151 | 1.94e-07 | |||
Translocase of outer mitochondrial membrane 40 (Tom40); Tom40 forms a channel in the mitochondrial outer membrane with a pore about 1.5 to 2.5 nanometers wide. It functions as a transport channel for unfolded protein chains and forms a complex with Tom5, Tom6, Tom7, and Tom22. The primary receptors Tom20 and Tom70 recruit the unfolded precursor protein from the mitochondrial-import stimulating factor (MSF) or cytosolic Hsc70. The precursor passes through the Tom40 channel and through another channel in the inner membrane, formed by Tim23, to be finally translocated into the mitochondrial matrix. The process depends on a proton motive force across the inner membrane and requires a contact site where the outer and inner membranes come close. Tom40 is also involved in inserting outer membrane proteins into the membrane, most likely not via a lateral opening in the pore, but by transfering precursor proteins to an outer membrane sorting and assembly machinery. Pssm-ID: 132766 [Multi-domain] Cd Length: 279 Bit Score: 48.74 E-value: 1.94e-07
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Blast search parameters | ||||
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