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Conserved domains on  [gi|2186591158|ref|NP_001387961|]
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non-selective voltage-gated ion channel VDAC1 isoform 7 [Homo sapiens]

Protein Classification

mitochondrial porin family protein( domain architecture ID 1295)

mitochondrial porin family protein is found in the outer membrane of mitochondria and is a pore-forming protein that allows ions and small molecules to pass through the membrane

Gene Ontology:  GO:0015288
PubMed:  11450972

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Porin3 super family cl03224
Eukaryotic porin family that forms channels in the mitochondrial outer membrane; The porin ...
1-154 1.42e-65

Eukaryotic porin family that forms channels in the mitochondrial outer membrane; The porin family 3 contains two sub-families that play vital roles in the mitochondrial outer membrane, a translocase for unfolded pre-proteins (Tom40) and the voltage-dependent anion channel (VDAC) that regulates the flux of mostly anionic metabolites through the outer mitochondrial membrane.


The actual alignment was detected with superfamily member cd07303:

Pssm-ID: 470762 [Multi-domain]  Cd Length: 274  Bit Score: 200.96  E-value: 1.42e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2186591158   1 MDFDIAGPSIRGALVLGYEGWLAGYQMNFETAKsRVTQSNFAVGYKTD--EFQLHTNVNDGTEFGGSIYQKVNKKLETAV 78
Cdd:cd07303   123 VDFDIAGPLIRGALVLGYEGWLAGYQMVFETVS-RVTQSNFAVGYKTDynEFQAHTNVNDGTEFGGSIYHKVNDKLEVGV 201
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2186591158  79 NLAWTAGNSNTRFGIAAKYQIDPDACFSAKVNNSSLIGLGYTQTLKPGIKLTLSALLDGKNvnaGGHKLGLGLEFQ 154
Cdd:cd07303   202 NLAATAGNSNTRFGIAAKYQVDPDACFSASVNNSSLVGLGYTQTLKPGIKLTLSALLDHKA---GGHKLGLGLEFQ 274
 
Name Accession Description Interval E-value
Porin3 cd07303
Eukaryotic porin family that forms channels in the mitochondrial outer membrane; The porin ...
1-154 1.42e-65

Eukaryotic porin family that forms channels in the mitochondrial outer membrane; The porin family 3 contains two sub-families that play vital roles in the mitochondrial outer membrane, a translocase for unfolded pre-proteins (Tom40) and the voltage-dependent anion channel (VDAC) that regulates the flux of mostly anionic metabolites through the outer mitochondrial membrane.


Pssm-ID: 132765 [Multi-domain]  Cd Length: 274  Bit Score: 200.96  E-value: 1.42e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2186591158   1 MDFDIAGPSIRGALVLGYEGWLAGYQMNFETAKsRVTQSNFAVGYKTD--EFQLHTNVNDGTEFGGSIYQKVNKKLETAV 78
Cdd:cd07303   123 VDFDIAGPLIRGALVLGYEGWLAGYQMVFETVS-RVTQSNFAVGYKTDynEFQAHTNVNDGTEFGGSIYHKVNDKLEVGV 201
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2186591158  79 NLAWTAGNSNTRFGIAAKYQIDPDACFSAKVNNSSLIGLGYTQTLKPGIKLTLSALLDGKNvnaGGHKLGLGLEFQ 154
Cdd:cd07303   202 NLAATAGNSNTRFGIAAKYQVDPDACFSASVNNSSLVGLGYTQTLKPGIKLTLSALLDHKA---GGHKLGLGLEFQ 274
Porin_3 pfam01459
Eukaryotic porin;
1-148 2.41e-49

Eukaryotic porin;


Pssm-ID: 460220 [Multi-domain]  Cd Length: 269  Bit Score: 159.30  E-value: 2.41e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2186591158   1 MDFDI-AGPSIRGALVLGYEGWLAGYQMNFETAKSRVTQSNFAVGYKTDEFQLHTN-VNDGTEFGGSIYQKVNKKLETAV 78
Cdd:pfam01459 121 LKVGLlAGPVVVGSYLQGVTGLALGAEASYDTASGKLTKYNAALGYTARDYIASLTlVNNGGVLTASYYHKVSEKLEVGA 200
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2186591158  79 NLAWTAGNSNTRFGIAAKYQIDPDACFSAKVNNSSLIGLGYTQTLKPGIKLTLSALLDGKNvNAGGHKLG 148
Cdd:pfam01459 201 ELTLNFSSNENTVTIGYKYDLDKSTTVKAKVNSNGKVGLLYEQKLRPGVTLTLSAEVDHKK-LNGAHKFG 269
 
Name Accession Description Interval E-value
Porin3 cd07303
Eukaryotic porin family that forms channels in the mitochondrial outer membrane; The porin ...
1-154 1.42e-65

Eukaryotic porin family that forms channels in the mitochondrial outer membrane; The porin family 3 contains two sub-families that play vital roles in the mitochondrial outer membrane, a translocase for unfolded pre-proteins (Tom40) and the voltage-dependent anion channel (VDAC) that regulates the flux of mostly anionic metabolites through the outer mitochondrial membrane.


Pssm-ID: 132765 [Multi-domain]  Cd Length: 274  Bit Score: 200.96  E-value: 1.42e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2186591158   1 MDFDIAGPSIRGALVLGYEGWLAGYQMNFETAKsRVTQSNFAVGYKTD--EFQLHTNVNDGTEFGGSIYQKVNKKLETAV 78
Cdd:cd07303   123 VDFDIAGPLIRGALVLGYEGWLAGYQMVFETVS-RVTQSNFAVGYKTDynEFQAHTNVNDGTEFGGSIYHKVNDKLEVGV 201
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2186591158  79 NLAWTAGNSNTRFGIAAKYQIDPDACFSAKVNNSSLIGLGYTQTLKPGIKLTLSALLDGKNvnaGGHKLGLGLEFQ 154
Cdd:cd07303   202 NLAATAGNSNTRFGIAAKYQVDPDACFSASVNNSSLVGLGYTQTLKPGIKLTLSALLDHKA---GGHKLGLGLEFQ 274
Porin3_VDAC cd07306
Voltage-dependent anion channel of the outer mitochondrial membrane; The voltage-dependent ...
1-154 4.01e-65

Voltage-dependent anion channel of the outer mitochondrial membrane; The voltage-dependent anion channel (VDAC) regulates the flux of mostly anionic metabolites through the outer mitochondrial membrane, which is highly permeable to small molecules. VDAC is the most abundant protein in the outer membrane, and membrane potentials can toggle VDAC between open or high-conducting and closed or low-conducting forms. VDAC binds to and is regulated in part by hexokinase, an interaction that renders mitochondria less susceptible to pro-apoptotic signals, most likely by intefering with VDAC's capability to respond to Bcl-2 family proteins. While VDAC appears to play a key role in mitochondrially induced cell death, a proposed involvement in forming the mitochondrial permeability transition pore, which is characteristic for damaged mitochondria and apoptosis, has been challenged by more recent studies.


Pssm-ID: 132767 [Multi-domain]  Cd Length: 276  Bit Score: 199.74  E-value: 4.01e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2186591158   1 MDFDI-AGPSIRGALVLGYEGWLAGYQMNFETAKSRVTQSNFAVGYKTDEFQLHTNVNDGTEFGGSIYQKVNKKLETAVN 79
Cdd:cd07306   122 ADVDLnKGPLVGASAVLGYKGFLLGAEVVYDTAKSKFTKYNFALGYTNGDFELSLKLNNGKTLRGSYFHKVSPRLAVGAK 201
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2186591158  80 LAWTAGNSNTRFGIAAKYQIDPDACFSAKVNNSSLIGLGYTQTLKPGIKLTLSALLDGKNVNAGGHKLGLGLEFQ 154
Cdd:cd07306   202 VTWYSGTNETTFAVGGQYALDPDALVKAKVNNDGQLGLSYQHKLRPGVTLTLSAGFDAKNLNQGGHKFGLSLSLK 276
Porin_3 pfam01459
Eukaryotic porin;
1-148 2.41e-49

Eukaryotic porin;


Pssm-ID: 460220 [Multi-domain]  Cd Length: 269  Bit Score: 159.30  E-value: 2.41e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2186591158   1 MDFDI-AGPSIRGALVLGYEGWLAGYQMNFETAKSRVTQSNFAVGYKTDEFQLHTN-VNDGTEFGGSIYQKVNKKLETAV 78
Cdd:pfam01459 121 LKVGLlAGPVVVGSYLQGVTGLALGAEASYDTASGKLTKYNAALGYTARDYIASLTlVNNGGVLTASYYHKVSEKLEVGA 200
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2186591158  79 NLAWTAGNSNTRFGIAAKYQIDPDACFSAKVNNSSLIGLGYTQTLKPGIKLTLSALLDGKNvNAGGHKLG 148
Cdd:pfam01459 201 ELTLNFSSNENTVTIGYKYDLDKSTTVKAKVNSNGKVGLLYEQKLRPGVTLTLSAEVDHKK-LNGAHKFG 269
Porin3_Tom40 cd07305
Translocase of outer mitochondrial membrane 40 (Tom40); Tom40 forms a channel in the ...
14-151 1.94e-07

Translocase of outer mitochondrial membrane 40 (Tom40); Tom40 forms a channel in the mitochondrial outer membrane with a pore about 1.5 to 2.5 nanometers wide. It functions as a transport channel for unfolded protein chains and forms a complex with Tom5, Tom6, Tom7, and Tom22. The primary receptors Tom20 and Tom70 recruit the unfolded precursor protein from the mitochondrial-import stimulating factor (MSF) or cytosolic Hsc70. The precursor passes through the Tom40 channel and through another channel in the inner membrane, formed by Tim23, to be finally translocated into the mitochondrial matrix. The process depends on a proton motive force across the inner membrane and requires a contact site where the outer and inner membranes come close. Tom40 is also involved in inserting outer membrane proteins into the membrane, most likely not via a lateral opening in the pore, but by transfering precursor proteins to an outer membrane sorting and assembly machinery.


Pssm-ID: 132766 [Multi-domain]  Cd Length: 279  Bit Score: 48.74  E-value: 1.94e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2186591158  14 LVLGYEG-WLAGYQMNfetaksrVTQSNFAVGYKTDEFQLHTNVNDGTEFGGSIYQKVNKKLETAVNLAWTAGNSNTRFG 92
Cdd:cd07305   149 LALGGELvYQRVPGNG-------ISVLSYAARYTAGNWIASGQLGAQGGLHLSYYRKLSDKLQLGVELELNLRTRESTAT 221
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2186591158  93 IAAKYQIdPDACFSAKVNNSSLIGLGYTQTLKPGIKLTLSALLDGKnvnAGGHKLGLGL 151
Cdd:cd07305   222 LGYQYDF-RQSRFRGSIDSNGKVSAVLEKRLPLPLSLLLSGELNHV---KNDYKFGFGL 276
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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