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Conserved domains on  [gi|2186591313|ref|NP_001387956|]
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non-selective voltage-gated ion channel VDAC1 isoform 5 [Homo sapiens]

Protein Classification

porin( domain architecture ID 10163986)

porin forms an aqueous channel for the diffusion of small hydrophilic molecules across the outer membrane, similar to mammalian voltage-dependent anion-selective channel proteins

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Porin3_VDAC cd07306
Voltage-dependent anion channel of the outer mitochondrial membrane; The voltage-dependent ...
 4-109 1.86e-47

Voltage-dependent anion channel of the outer mitochondrial membrane; The voltage-dependent anion channel (VDAC) regulates the flux of mostly anionic metabolites through the outer mitochondrial membrane, which is highly permeable to small molecules. VDAC is the most abundant protein in the outer membrane, and membrane potentials can toggle VDAC between open or high-conducting and closed or low-conducting forms. VDAC binds to and is regulated in part by hexokinase, an interaction that renders mitochondria less susceptible to pro-apoptotic signals, most likely by intefering with VDAC's capability to respond to Bcl-2 family proteins. While VDAC appears to play a key role in mitochondrially induced cell death, a proposed involvement in forming the mitochondrial permeability transition pore, which is characteristic for damaged mitochondria and apoptosis, has been challenged by more recent studies.


:

Pssm-ID: 132767 [Multi-domain]  Cd Length: 276  Bit Score: 154.29  E-value: 1.86e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2186591313   4 PPTYADLGKSARDVFTKGYGFGLIKLDLKTKSENGLEFTSSGSANTETTKVTGSLETKYRWteYGLTFTEKWNTDNTLGT 83
Cdd:cd07306     1 PPTYFDIGKSAKDLLTKGYNFGAWKLDVKTKTPNGVEFTSTGSKKPDTGKVSGSLEAKYKI--KGLTLTQKWNTDNVLLT 78

                          90       100
                  ....*....|....*....|....*.
gi 2186591313  84 EITVEDQLARGLKLTFDSSFSPNTGY 109
Cdd:cd07306    79 EITIEDLLAPGLKLTLDTTFPPNTGK 104
 
Name Accession Description Interval E-value
Porin3_VDAC cd07306
Voltage-dependent anion channel of the outer mitochondrial membrane; The voltage-dependent ...
 4-109 1.86e-47

Voltage-dependent anion channel of the outer mitochondrial membrane; The voltage-dependent anion channel (VDAC) regulates the flux of mostly anionic metabolites through the outer mitochondrial membrane, which is highly permeable to small molecules. VDAC is the most abundant protein in the outer membrane, and membrane potentials can toggle VDAC between open or high-conducting and closed or low-conducting forms. VDAC binds to and is regulated in part by hexokinase, an interaction that renders mitochondria less susceptible to pro-apoptotic signals, most likely by intefering with VDAC's capability to respond to Bcl-2 family proteins. While VDAC appears to play a key role in mitochondrially induced cell death, a proposed involvement in forming the mitochondrial permeability transition pore, which is characteristic for damaged mitochondria and apoptosis, has been challenged by more recent studies.


Pssm-ID: 132767 [Multi-domain]  Cd Length: 276  Bit Score: 154.29  E-value: 1.86e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2186591313   4 PPTYADLGKSARDVFTKGYGFGLIKLDLKTKSENGLEFTSSGSANTETTKVTGSLETKYRWteYGLTFTEKWNTDNTLGT 83
Cdd:cd07306     1 PPTYFDIGKSAKDLLTKGYNFGAWKLDVKTKTPNGVEFTSTGSKKPDTGKVSGSLEAKYKI--KGLTLTQKWNTDNVLLT 78

                          90       100
                  ....*....|....*....|....*.
gi 2186591313  84 EITVEDQLARGLKLTFDSSFSPNTGY 109
Cdd:cd07306    79 EITIEDLLAPGLKLTLDTTFPPNTGK 104
Porin_3 pfam01459
Eukaryotic porin;
3-107 1.61e-38

Eukaryotic porin;


Pssm-ID: 460220 [Multi-domain]  Cd Length: 269  Bit Score: 131.18  E-value: 1.61e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2186591313   3 VPPTYADLGKSARDVFTKGYGFGLIKLDLKTKSENGLEFTSSGSANTETTKVTGSLETKYRWteYGLTFTEKWNTDNTLG 82
Cdd:pfam01459   1 NPGTYEDIGKEAKDLLNKDYHFDGAKLDVTTKSGLGVAFQVSGSFSLGSGLSSGDFEAKYKD--KGLTLTLKGDTDNDLS 78

                          90       100
                  ....*....|....*....|....*
gi 2186591313  83 TEITVEDQLARGLKLTFDSSFSPNT 107
Cdd:pfam01459  79 TTATVNEQLTPGLKTKLSTQFVPGK 103
 
Name Accession Description Interval E-value
Porin3_VDAC cd07306
Voltage-dependent anion channel of the outer mitochondrial membrane; The voltage-dependent ...
 4-109 1.86e-47

Voltage-dependent anion channel of the outer mitochondrial membrane; The voltage-dependent anion channel (VDAC) regulates the flux of mostly anionic metabolites through the outer mitochondrial membrane, which is highly permeable to small molecules. VDAC is the most abundant protein in the outer membrane, and membrane potentials can toggle VDAC between open or high-conducting and closed or low-conducting forms. VDAC binds to and is regulated in part by hexokinase, an interaction that renders mitochondria less susceptible to pro-apoptotic signals, most likely by intefering with VDAC's capability to respond to Bcl-2 family proteins. While VDAC appears to play a key role in mitochondrially induced cell death, a proposed involvement in forming the mitochondrial permeability transition pore, which is characteristic for damaged mitochondria and apoptosis, has been challenged by more recent studies.


Pssm-ID: 132767 [Multi-domain]  Cd Length: 276  Bit Score: 154.29  E-value: 1.86e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2186591313   4 PPTYADLGKSARDVFTKGYGFGLIKLDLKTKSENGLEFTSSGSANTETTKVTGSLETKYRWteYGLTFTEKWNTDNTLGT 83
Cdd:cd07306     1 PPTYFDIGKSAKDLLTKGYNFGAWKLDVKTKTPNGVEFTSTGSKKPDTGKVSGSLEAKYKI--KGLTLTQKWNTDNVLLT 78

                          90       100
                  ....*....|....*....|....*.
gi 2186591313  84 EITVEDQLARGLKLTFDSSFSPNTGY 109
Cdd:cd07306    79 EITIEDLLAPGLKLTLDTTFPPNTGK 104
Porin_3 pfam01459
Eukaryotic porin;
3-107 1.61e-38

Eukaryotic porin;


Pssm-ID: 460220 [Multi-domain]  Cd Length: 269  Bit Score: 131.18  E-value: 1.61e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2186591313   3 VPPTYADLGKSARDVFTKGYGFGLIKLDLKTKSENGLEFTSSGSANTETTKVTGSLETKYRWteYGLTFTEKWNTDNTLG 82
Cdd:pfam01459   1 NPGTYEDIGKEAKDLLNKDYHFDGAKLDVTTKSGLGVAFQVSGSFSLGSGLSSGDFEAKYKD--KGLTLTLKGDTDNDLS 78

                          90       100
                  ....*....|....*....|....*
gi 2186591313  83 TEITVEDQLARGLKLTFDSSFSPNT 107
Cdd:pfam01459  79 TTATVNEQLTPGLKTKLSTQFVPGK 103
Porin3 cd07303
Eukaryotic porin family that forms channels in the mitochondrial outer membrane; The porin ...
 6-109 3.30e-34

Eukaryotic porin family that forms channels in the mitochondrial outer membrane; The porin family 3 contains two sub-families that play vital roles in the mitochondrial outer membrane, a translocase for unfolded pre-proteins (Tom40) and the voltage-dependent anion channel (VDAC) that regulates the flux of mostly anionic metabolites through the outer mitochondrial membrane.


Pssm-ID: 132765 [Multi-domain]  Cd Length: 274  Bit Score: 120.07  E-value: 3.30e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2186591313   6 TYADLGKSARDVFTKGYgFGLIKLDLKTKSENglEFTSSGSANTET----TKVTGSLETKYRWTEYGLTFTEKWNTDNTL 81
Cdd:cd07303     1 TYAELGKSARDLFTKGY-GGGIKLDVKTKSEL--EFTSSGSANTETiestTKVGGSLETKYRWSPYGLTFTEKWNTDNTL 77

                          90       100
                  ....*....|....*....|....*...
gi 2186591313  82 GTEITVEDQLARGLKLTFDSSFSPNTGY 109
Cdd:cd07303    78 GLEITVEDQLSRGLKSTFDSSFSPNTGK 105
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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