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Conserved domains on  [gi|2186289376|ref|NP_001387875|]
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deoxyribonuclease TATDN1 isoform 2 [Rattus norvegicus]

Protein Classification

TatD family hydrolase( domain architecture ID 10101392)

TatD family hydrolase is a metal-dependent hydrolase similar to Saccharomyces cerevisiae deoxyribonuclease Tat-D, a cytoplasmic protein that exhibits magnesium-dependent exo- and endonuclease activities, and to Homo sapiens deoxyribonuclease TATDN1 which catalyzes (in vitro) the decatenation of kinetoplast DNA

CATH:  3.20.20.140
EC:  3.1.-.-
Gene Ontology:  GO:0004536|GO:0046872|GO:0016788

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
TatD_DNAse cd01310
TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent ...
3-226 3.44e-75

TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity.


:

Pssm-ID: 238635 [Multi-domain]  Cd Length: 251  Bit Score: 227.46  E-value: 3.44e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2186289376   3 FSTVGCHPTRCDEFEKDSPDQylagLLHLAENNKgkVVAIGECGLDFDRLQFcPKDTQLKYFEKQFELSEQTKLPMFLHC 82
Cdd:cd01310    56 YAAVGLHPHDADEHVDEDLDL----LELLAANPK--VVAIGEIGLDYYRDKS-PREVQKEVFRAQLELAKELNLPVVIHS 128
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2186289376  83 RNSHTEFLDIMRRNRDRcVGGVVHSFDGTKEAAAALIDLDLYIGFNGCSLKTEAN--LEVLKSIPSEKLMIETDAPWCGV 160
Cdd:cd01310   129 RDAHEDVLEILKEYGPP-KRGVFHCFSGSAEEAKELLDLGFYISISGIVTFKNANelREVVKEIPLERLLLETDSPYLAP 207
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2186289376 161 KSTHagskyiktafptkkkweagcclKDRNEPCHIVQILEIMSAVREEDPLELANTLYNNTIKIFF 226
Cdd:cd01310   208 VPFR----------------------GKRNEPAYVKHVAEKIAELKGISVEEVAEVTTENAKRLFG 251
 
Name Accession Description Interval E-value
TatD_DNAse cd01310
TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent ...
3-226 3.44e-75

TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity.


Pssm-ID: 238635 [Multi-domain]  Cd Length: 251  Bit Score: 227.46  E-value: 3.44e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2186289376   3 FSTVGCHPTRCDEFEKDSPDQylagLLHLAENNKgkVVAIGECGLDFDRLQFcPKDTQLKYFEKQFELSEQTKLPMFLHC 82
Cdd:cd01310    56 YAAVGLHPHDADEHVDEDLDL----LELLAANPK--VVAIGEIGLDYYRDKS-PREVQKEVFRAQLELAKELNLPVVIHS 128
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2186289376  83 RNSHTEFLDIMRRNRDRcVGGVVHSFDGTKEAAAALIDLDLYIGFNGCSLKTEAN--LEVLKSIPSEKLMIETDAPWCGV 160
Cdd:cd01310   129 RDAHEDVLEILKEYGPP-KRGVFHCFSGSAEEAKELLDLGFYISISGIVTFKNANelREVVKEIPLERLLLETDSPYLAP 207
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2186289376 161 KSTHagskyiktafptkkkweagcclKDRNEPCHIVQILEIMSAVREEDPLELANTLYNNTIKIFF 226
Cdd:cd01310   208 VPFR----------------------GKRNEPAYVKHVAEKIAELKGISVEEVAEVTTENAKRLFG 251
TatD_DNase pfam01026
TatD related DNase; This family of proteins are related to a large superfamily of ...
3-225 1.97e-62

TatD related DNase; This family of proteins are related to a large superfamily of metalloenzymes. TatD, a member of this family has been shown experimentally to be a DNase enzyme.


Pssm-ID: 425997 [Multi-domain]  Cd Length: 253  Bit Score: 195.17  E-value: 1.97e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2186289376   3 FSTVGCHPTRCDEFEKDSpdqyLAGLLHLAENnkGKVVAIGECGLDFDRLQFCPKDTQLKYFEKQFELSEQTKLPMFLHC 82
Cdd:pfam01026  56 YAAVGVHPHEADEASEDD----LEALEKLAEH--PKVVAIGEIGLDYYYVDESPKEAQEEVFRRQLELAKELGLPVVIHT 129
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2186289376  83 RNSHTEFLDIMRRNRDRCVGGVVHSFDGTKEAAAALIDLDLYIGFNGCSLKTEANL--EVLKSIPSEKLMIETDAPWCGv 160
Cdd:pfam01026 130 RDAEEDLLEILKEAGAPGARGVLHCFTGSVEEARKFLDLGFYISISGIVTFKNAKKlrEVAAAIPLDRLLVETDAPYLA- 208
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2186289376 161 ksthagskyiktafPTKKKweagcclKDRNEPCHIVQILEIMSAVREEDPLELANTLYNNTIKIF 225
Cdd:pfam01026 209 --------------PVPYR-------GKRNEPAYVPYVVEKLAELKGISPEEVAEITTENAERLF 252
TatD COG0084
3'->5' ssDNA/RNA exonuclease TatD [Cell motility];
3-225 2.33e-61

3'->5' ssDNA/RNA exonuclease TatD [Cell motility];


Pssm-ID: 439854 [Multi-domain]  Cd Length: 253  Bit Score: 192.19  E-value: 2.33e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2186289376   3 FSTVGCHPTRCDEFekdsPDQYLAGLLHLAENNKgkVVAIGECGLDFDRlQFCPKDTQLKYFEKQFELSEQTKLPMFLHC 82
Cdd:COG0084    56 YAAVGLHPHDAKEH----DEEDLAELEELAAHPK--VVAIGEIGLDYYR-DKSPREVQEEAFRAQLALAKELGLPVIIHS 128
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2186289376  83 RNSHTEFLDIMRRNRDRCVGGVVHSFDGTKEAAAALIDLDLYIGFNG-CSLKTEANL-EVLKSIPSEKLMIETDAPwcgv 160
Cdd:COG0084   129 RDAHDDTLEILKEEGAPALGGVFHCFSGSLEQAKRALDLGFYISFGGiVTFKNAKKLrEVAAAIPLDRLLLETDAP---- 204
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2186289376 161 ksthagskYIkTAFPTKKKweagcclkdRNEPCHIVQILEIMSAVREEDPLELANTLYNNTIKIF 225
Cdd:COG0084   205 --------YL-APVPFRGK---------RNEPAYVPHVAEKLAELRGISLEELAEATTANARRLF 251
TIGR00010 TIGR00010
hydrolase, TatD family; PSI-BLAST, starting with a urease alpha subunit, finds a large ...
1-227 1.34e-41

hydrolase, TatD family; PSI-BLAST, starting with a urease alpha subunit, finds a large superfamily of proteins, including a number of different enzymes that act as hydrolases at C-N bonds other than peptide bonds (EC 3.5.-.-), many uncharacterized proteins, and the members of this family. Several genomes have multiple paralogs related to this family. However, a set of 17 proteins can be found, one each from 17 of the first 20 genomes, such that each member forms a bidirectional best hit across genomes with all other members of the set. This core set (and one other near-perfect member), but not the other paralogs, form the seed for this model. Additionally, members of the seed alignment and all trusted hits, but not all paralogs, have a conserved motif DxHxH near the amino end. The member from E. coli was recently shown to have DNase activity. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 272852 [Multi-domain]  Cd Length: 252  Bit Score: 141.63  E-value: 1.34e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2186289376   1 MFFSTVGCHPTRCDEFEKDSPDQylagLLHLAenNKGKVVAIGECGLDFdRLQFCPKDTQLKYFEKQFELSEQTKLPMFL 80
Cdd:TIGR00010  54 NVYAAVGVHPLDVDDDTKEDIKE----LERLA--AHPKVVAIGETGLDY-YKADEYKRRQEEVFRAQLQLAEELNLPVII 126
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2186289376  81 HCRNSHTEFLDIMRRNRDRCvGGVVHSFDGTKEAAAALIDLDLYIGFNG-CSLKTEANL-EVLKSIPSEKLMIETDAPWC 158
Cdd:TIGR00010 127 HARDAEEDVLDILREEKPKV-GGVLHCFTGDAELAKKLLDLGFYISISGiVTFKNAKSLrEVVRKIPLERLLVETDSPYL 205
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2186289376 159 gvksthagskyikTAFPTKKKweagcclkdRNEPCHIVQILEIMSAVREEDPLELANTLYNNtIKIFFS 227
Cdd:TIGR00010 206 -------------APVPYRGK---------RNEPAFVRYTVEAIAEIKGIDVEELAQITTKN-AKRLFG 251
PRK10425 PRK10425
3'-5' ssDNA/RNA exonuclease TatD;
4-225 7.58e-41

3'-5' ssDNA/RNA exonuclease TatD;


Pssm-ID: 182449  Cd Length: 258  Bit Score: 140.19  E-value: 7.58e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2186289376   4 STVGCHPTRCDEFEKDSPDQylagLLHLAEnnKGKVVAIGECGLDFDRlQFCPKDTQLKYFEKQFELSEQTKLPMFLHCR 83
Cdd:PRK10425   57 STAGVHPHDSSQWQAATEEA----IIELAA--QPEVVAIGECGLDFNR-NFSTPEEQERAFVAQLAIAAELNMPVFMHCR 129
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2186289376  84 NSHTEFLDIMRRNRDRCVGGVVHSFDGTKEAAAALIDLDLYIGFNG--CSLKTEANL-EVLKSIPSEKLMIETDAPWCGV 160
Cdd:PRK10425  130 DAHERFMALLEPWLDKLPGAVLHCFTGTREEMQACLARGLYIGITGwvCDERRGLELrELLPLIPAERLLLETDAPYLLP 209
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2186289376 161 KSTHAGskyiktafPTKKkweagcclkdRNEPCHIVQILEIMSAVREEDPLELANTLYNNTIKIF 225
Cdd:PRK10425  210 RDLTPK--------PASR----------RNEPAFLPHILQRIAHWRGEDAAWLAATTDANARTLF 256
 
Name Accession Description Interval E-value
TatD_DNAse cd01310
TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent ...
3-226 3.44e-75

TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity.


Pssm-ID: 238635 [Multi-domain]  Cd Length: 251  Bit Score: 227.46  E-value: 3.44e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2186289376   3 FSTVGCHPTRCDEFEKDSPDQylagLLHLAENNKgkVVAIGECGLDFDRLQFcPKDTQLKYFEKQFELSEQTKLPMFLHC 82
Cdd:cd01310    56 YAAVGLHPHDADEHVDEDLDL----LELLAANPK--VVAIGEIGLDYYRDKS-PREVQKEVFRAQLELAKELNLPVVIHS 128
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2186289376  83 RNSHTEFLDIMRRNRDRcVGGVVHSFDGTKEAAAALIDLDLYIGFNGCSLKTEAN--LEVLKSIPSEKLMIETDAPWCGV 160
Cdd:cd01310   129 RDAHEDVLEILKEYGPP-KRGVFHCFSGSAEEAKELLDLGFYISISGIVTFKNANelREVVKEIPLERLLLETDSPYLAP 207
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2186289376 161 KSTHagskyiktafptkkkweagcclKDRNEPCHIVQILEIMSAVREEDPLELANTLYNNTIKIFF 226
Cdd:cd01310   208 VPFR----------------------GKRNEPAYVKHVAEKIAELKGISVEEVAEVTTENAKRLFG 251
TatD_DNase pfam01026
TatD related DNase; This family of proteins are related to a large superfamily of ...
3-225 1.97e-62

TatD related DNase; This family of proteins are related to a large superfamily of metalloenzymes. TatD, a member of this family has been shown experimentally to be a DNase enzyme.


Pssm-ID: 425997 [Multi-domain]  Cd Length: 253  Bit Score: 195.17  E-value: 1.97e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2186289376   3 FSTVGCHPTRCDEFEKDSpdqyLAGLLHLAENnkGKVVAIGECGLDFDRLQFCPKDTQLKYFEKQFELSEQTKLPMFLHC 82
Cdd:pfam01026  56 YAAVGVHPHEADEASEDD----LEALEKLAEH--PKVVAIGEIGLDYYYVDESPKEAQEEVFRRQLELAKELGLPVVIHT 129
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2186289376  83 RNSHTEFLDIMRRNRDRCVGGVVHSFDGTKEAAAALIDLDLYIGFNGCSLKTEANL--EVLKSIPSEKLMIETDAPWCGv 160
Cdd:pfam01026 130 RDAEEDLLEILKEAGAPGARGVLHCFTGSVEEARKFLDLGFYISISGIVTFKNAKKlrEVAAAIPLDRLLVETDAPYLA- 208
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2186289376 161 ksthagskyiktafPTKKKweagcclKDRNEPCHIVQILEIMSAVREEDPLELANTLYNNTIKIF 225
Cdd:pfam01026 209 --------------PVPYR-------GKRNEPAYVPYVVEKLAELKGISPEEVAEITTENAERLF 252
TatD COG0084
3'->5' ssDNA/RNA exonuclease TatD [Cell motility];
3-225 2.33e-61

3'->5' ssDNA/RNA exonuclease TatD [Cell motility];


Pssm-ID: 439854 [Multi-domain]  Cd Length: 253  Bit Score: 192.19  E-value: 2.33e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2186289376   3 FSTVGCHPTRCDEFekdsPDQYLAGLLHLAENNKgkVVAIGECGLDFDRlQFCPKDTQLKYFEKQFELSEQTKLPMFLHC 82
Cdd:COG0084    56 YAAVGLHPHDAKEH----DEEDLAELEELAAHPK--VVAIGEIGLDYYR-DKSPREVQEEAFRAQLALAKELGLPVIIHS 128
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2186289376  83 RNSHTEFLDIMRRNRDRCVGGVVHSFDGTKEAAAALIDLDLYIGFNG-CSLKTEANL-EVLKSIPSEKLMIETDAPwcgv 160
Cdd:COG0084   129 RDAHDDTLEILKEEGAPALGGVFHCFSGSLEQAKRALDLGFYISFGGiVTFKNAKKLrEVAAAIPLDRLLLETDAP---- 204
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2186289376 161 ksthagskYIkTAFPTKKKweagcclkdRNEPCHIVQILEIMSAVREEDPLELANTLYNNTIKIF 225
Cdd:COG0084   205 --------YL-APVPFRGK---------RNEPAYVPHVAEKLAELRGISLEELAEATTANARRLF 251
TIGR00010 TIGR00010
hydrolase, TatD family; PSI-BLAST, starting with a urease alpha subunit, finds a large ...
1-227 1.34e-41

hydrolase, TatD family; PSI-BLAST, starting with a urease alpha subunit, finds a large superfamily of proteins, including a number of different enzymes that act as hydrolases at C-N bonds other than peptide bonds (EC 3.5.-.-), many uncharacterized proteins, and the members of this family. Several genomes have multiple paralogs related to this family. However, a set of 17 proteins can be found, one each from 17 of the first 20 genomes, such that each member forms a bidirectional best hit across genomes with all other members of the set. This core set (and one other near-perfect member), but not the other paralogs, form the seed for this model. Additionally, members of the seed alignment and all trusted hits, but not all paralogs, have a conserved motif DxHxH near the amino end. The member from E. coli was recently shown to have DNase activity. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 272852 [Multi-domain]  Cd Length: 252  Bit Score: 141.63  E-value: 1.34e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2186289376   1 MFFSTVGCHPTRCDEFEKDSPDQylagLLHLAenNKGKVVAIGECGLDFdRLQFCPKDTQLKYFEKQFELSEQTKLPMFL 80
Cdd:TIGR00010  54 NVYAAVGVHPLDVDDDTKEDIKE----LERLA--AHPKVVAIGETGLDY-YKADEYKRRQEEVFRAQLQLAEELNLPVII 126
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2186289376  81 HCRNSHTEFLDIMRRNRDRCvGGVVHSFDGTKEAAAALIDLDLYIGFNG-CSLKTEANL-EVLKSIPSEKLMIETDAPWC 158
Cdd:TIGR00010 127 HARDAEEDVLDILREEKPKV-GGVLHCFTGDAELAKKLLDLGFYISISGiVTFKNAKSLrEVVRKIPLERLLVETDSPYL 205
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2186289376 159 gvksthagskyikTAFPTKKKweagcclkdRNEPCHIVQILEIMSAVREEDPLELANTLYNNtIKIFFS 227
Cdd:TIGR00010 206 -------------APVPYRGK---------RNEPAFVRYTVEAIAEIKGIDVEELAQITTKN-AKRLFG 251
PRK10425 PRK10425
3'-5' ssDNA/RNA exonuclease TatD;
4-225 7.58e-41

3'-5' ssDNA/RNA exonuclease TatD;


Pssm-ID: 182449  Cd Length: 258  Bit Score: 140.19  E-value: 7.58e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2186289376   4 STVGCHPTRCDEFEKDSPDQylagLLHLAEnnKGKVVAIGECGLDFDRlQFCPKDTQLKYFEKQFELSEQTKLPMFLHCR 83
Cdd:PRK10425   57 STAGVHPHDSSQWQAATEEA----IIELAA--QPEVVAIGECGLDFNR-NFSTPEEQERAFVAQLAIAAELNMPVFMHCR 129
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2186289376  84 NSHTEFLDIMRRNRDRCVGGVVHSFDGTKEAAAALIDLDLYIGFNG--CSLKTEANL-EVLKSIPSEKLMIETDAPWCGV 160
Cdd:PRK10425  130 DAHERFMALLEPWLDKLPGAVLHCFTGTREEMQACLARGLYIGITGwvCDERRGLELrELLPLIPAERLLLETDAPYLLP 209
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2186289376 161 KSTHAGskyiktafPTKKkweagcclkdRNEPCHIVQILEIMSAVREEDPLELANTLYNNTIKIF 225
Cdd:PRK10425  210 RDLTPK--------PASR----------RNEPAFLPHILQRIAHWRGEDAAWLAATTDANARTLF 256
PRK11449 PRK11449
metal-dependent hydrolase;
2-225 8.98e-25

metal-dependent hydrolase;


Pssm-ID: 171118 [Multi-domain]  Cd Length: 258  Bit Score: 98.11  E-value: 8.98e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2186289376   2 FFSTVGCHPTRCDEFEKDSPDQYLAGLlhlaENNKGKVVAIGECGLDF--DRLQFcpkDTQLKYFEKQFELSEQTKLPMF 79
Cdd:PRK11449   59 LYAALGLHPGMLEKHSDVSLDQLQQAL----ERRPAKVVAVGEIGLDLfgDDPQF---ERQQWLLDEQLKLAKRYDLPVI 131
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2186289376  80 LHCRNSHTEFLDIMRRNRDRCVGgVVHSFDGTKEAAAALIDLDLYIGFNGCSLKTEAN--LEVLKSIPSEKLMIETDAPW 157
Cdd:PRK11449  132 LHSRRTHDKLAMHLKRHDLPRTG-VVHGFSGSLQQAERFVQLGYKIGVGGTITYPRASktRDVIAKLPLASLLLETDAPD 210
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2186289376 158 CGVKSTHAgskyiktafptkkkweagcclkDRNEPCHIVQILEIMSAVREEDPLELANTLYNNTIKIF 225
Cdd:PRK11449  211 MPLNGFQG----------------------QPNRPEQAARVFDVLCELRPEPADEIAEVLLNNTYTLF 256
PRK10812 PRK10812
putative DNAse; Provisional
7-157 1.45e-15

putative DNAse; Provisional


Pssm-ID: 236767 [Multi-domain]  Cd Length: 265  Bit Score: 73.25  E-value: 1.45e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2186289376   7 GCHPTRCDEfekdsPDQYlAGLLHLAENNKgkVVAIGECGLDFdrlqFCPKDT---QLKYFEKQFELSEQTKLPMFLHCR 83
Cdd:PRK10812   65 GVHPLNQDE-----PYDV-EELRRLAAEEG--VVAMGETGLDY----YYTPETkvrQQESFRHHIQIGRELNKPVIVHTR 132
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2186289376  84 NSHTEFLDIMRRNRDRCVGGVVHSFDGTKEAAAALIDLDLYIGFNGcsLKTEANLEVLKS----IPSEKLMIETDAPW 157
Cdd:PRK10812  133 DARADTLAILREEKVTDCGGVLHCFTEDRETAGKLLDLGFYISFSG--IVTFRNAEQLRDaaryVPLDRLLVETDSPY 208
COG1099 COG1099
Predicted metal-dependent hydrolase, TIM-barrel fold [General function prediction only];
36-157 4.91e-05

Predicted metal-dependent hydrolase, TIM-barrel fold [General function prediction only];


Pssm-ID: 440716 [Multi-domain]  Cd Length: 260  Bit Score: 43.29  E-value: 4.91e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2186289376  36 KGKVVAIGECGLDFDRlqfcpkDTQLKYFEKQFELSEQTKLPMFLHC--RN--SHTE-FLDIMRR---NRDRCVggVVHs 107
Cdd:COG1099    98 KEGVVAIGEIGLDDQT------PEEEEVFREQLELARELDLPVLVHTphRDkkEGTRrILDVLREsglDPERVL--IDH- 168
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2186289376 108 fdGTKEAAAALIDLDLYIGFN---GCSLKTEANLEVLKSIPSEKLMIETDAPW 157
Cdd:COG1099   169 --NNEETVKLVLDTGFWAGFTiypSTKMSPERAVDILEEYGTERILVNSAADW 219
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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