NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2172571293|ref|NP_001386111|]
View 

DNA-dependent metalloprotease SPRTN [Rattus norvegicus]

Protein Classification

DNA repair protein RAD18; RING-H2 finger protein( domain architecture ID 13923983)

DNA repair protein RAD18 is an E3 ubiquitin ligase that is involved in DNA damage repair| RING-H2 finger protein may act as an E3 ubiquitin ligase, mediating the ubiquitination of target proteins by bringing the ubiquitin-charged E2 ubiquitin-conjugating enzyme and the acceptor protein together to enable the direct transfer of ubiquitin; contains a galacturonan-binding domain

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
SprT smart00731
SprT homologues; Predicted to have roles in transcription elongation. Contains a conserved ...
 43-212 3.69e-47

SprT homologues; Predicted to have roles in transcription elongation. Contains a conserved HExxH motif, indicating a metalloprotease function.


:

Pssm-ID: 214794 [Multi-domain]  Cd Length: 146  Bit Score: 160.18  E-value: 3.69e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2172571293   43 PDLQALFLQFNDRFFWGQLEAVEVKWSVRMTLCAGICTYegrgGMCSIRLSEPLLKLRPRKDLVETLLHEMIHAYLFVTN 122
Cdd:smart00731   1 QELTQRLEDASLRVFGRKLPHPKVVWNKRLRKTGGRCLL----KSAEIRLNPKLLTENGRDRLRETLLHELCHAALYLFG 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2172571293  123 NDKdreGHGPEFCKHMHRINQLTGaniTVYHTFHDEVdeYRRHWWRCNGpCQHkqpYYGYVKRATNRapsahdyWWADHQ 202
Cdd:smart00731  77 RGY---GHGDEWKRWMRQVNGLFP---ERCHTFLIES--VKKYPYRCTG-CGQ---RYLRVRRSNNV-------SRYRCG 137

                          170
                   ....*....|
gi 2172571293  203 KtCGGTYIKI 212
Cdd:smart00731 138 K-CGGKLILI 146
ZnF_Rad18 smart00734
Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative ...
 461-484 1.03e-06

Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative DNA repair. This zinc finger is likely to bind nucleic-acids.


:

Pssm-ID: 128973 [Multi-domain]  Cd Length: 24  Bit Score: 44.91  E-value: 1.03e-06
                           10        20
                   ....*....|....*....|....
gi 2172571293  461 LVNCPVCQGVVLESQINEHLDRCL 484
Cdd:smart00734   1 LVQCPVCFREVPENLINSHLDSCL 24
rad18 super family cl36700
DNA repair protein rad18; All proteins in this family for which functions are known are ...
 375-484 1.72e-04

DNA repair protein rad18; All proteins in this family for which functions are known are involved in nucleotide excision repair.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


The actual alignment was detected with superfamily member TIGR00599:

Pssm-ID: 273165 [Multi-domain]  Cd Length: 397  Bit Score: 43.84  E-value: 1.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2172571293 375 SRASLRNSSKVTAPASATVTSAAGTSAA-----ISREESGSEDQfLNKRPRLEDRTALNNIKEQTQSGGDLEDSSRPTAI 449
Cdd:TIGR00599  91 LRPSLLEFLRIPKTTPVENPDLAGPENSskielIEESESDGVDA-EDEDLQRSATSSRALAARSTADILQLSSDPSKRND 169

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2172571293 450 STPRSSGGQRRLVNCPVCQGVVLESQINEHLD-RCL 484
Cdd:TIGR00599 170 ADYRSEPPNEGLVQCPICQQRMPEKAVERHLDsECL 205
 
Name Accession Description Interval E-value
SprT smart00731
SprT homologues; Predicted to have roles in transcription elongation. Contains a conserved ...
 43-212 3.69e-47

SprT homologues; Predicted to have roles in transcription elongation. Contains a conserved HExxH motif, indicating a metalloprotease function.


Pssm-ID: 214794 [Multi-domain]  Cd Length: 146  Bit Score: 160.18  E-value: 3.69e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2172571293   43 PDLQALFLQFNDRFFWGQLEAVEVKWSVRMTLCAGICTYegrgGMCSIRLSEPLLKLRPRKDLVETLLHEMIHAYLFVTN 122
Cdd:smart00731   1 QELTQRLEDASLRVFGRKLPHPKVVWNKRLRKTGGRCLL----KSAEIRLNPKLLTENGRDRLRETLLHELCHAALYLFG 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2172571293  123 NDKdreGHGPEFCKHMHRINQLTGaniTVYHTFHDEVdeYRRHWWRCNGpCQHkqpYYGYVKRATNRapsahdyWWADHQ 202
Cdd:smart00731  77 RGY---GHGDEWKRWMRQVNGLFP---ERCHTFLIES--VKKYPYRCTG-CGQ---RYLRVRRSNNV-------SRYRCG 137

                          170
                   ....*....|
gi 2172571293  203 KtCGGTYIKI 212
Cdd:smart00731 138 K-CGGKLILI 146
SprT-like pfam10263
SprT-like family; This family represents a domain found in eukaryotes and prokaryotes. The ...
 45-153 2.28e-42

SprT-like family; This family represents a domain found in eukaryotes and prokaryotes. The domain contains a characteriztic motif of the zinc metallopeptidases. This family includes the bacterial SprT protein.


Pssm-ID: 463033  Cd Length: 106  Bit Score: 146.26  E-value: 2.28e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2172571293  45 LQALFLQFNDRFFWGQL-EAVEVKWSVRMTLCAGICTYEGRggmCSIRLSEPLLKLRPRKDLVETLLHEMIHAYLFVTNN 123
Cdd:pfam10263   1 LEELFQQLNDEFFRGFLlPGVSVRWSKRLRTTAGRAHLKRK---NEIRLSEPLLDENPEEFLRETLLHEMIHAYLFVLFG 77

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2172571293 124 dkDREGHGPEFCKHMHRINQL-TGANITVYH 153
Cdd:pfam10263  78 --RRRGHGPEFKAWMERINEAqTGLPITTYH 106
ZnF_Rad18 smart00734
Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative ...
 461-484 1.03e-06

Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative DNA repair. This zinc finger is likely to bind nucleic-acids.


Pssm-ID: 128973 [Multi-domain]  Cd Length: 24  Bit Score: 44.91  E-value: 1.03e-06
                           10        20
                   ....*....|....*....|....
gi 2172571293  461 LVNCPVCQGVVLESQINEHLDRCL 484
Cdd:smart00734   1 LVQCPVCFREVPENLINSHLDSCL 24
rad18 TIGR00599
DNA repair protein rad18; All proteins in this family for which functions are known are ...
 375-484 1.72e-04

DNA repair protein rad18; All proteins in this family for which functions are known are involved in nucleotide excision repair.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273165 [Multi-domain]  Cd Length: 397  Bit Score: 43.84  E-value: 1.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2172571293 375 SRASLRNSSKVTAPASATVTSAAGTSAA-----ISREESGSEDQfLNKRPRLEDRTALNNIKEQTQSGGDLEDSSRPTAI 449
Cdd:TIGR00599  91 LRPSLLEFLRIPKTTPVENPDLAGPENSskielIEESESDGVDA-EDEDLQRSATSSRALAARSTADILQLSSDPSKRND 169

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2172571293 450 STPRSSGGQRRLVNCPVCQGVVLESQINEHLD-RCL 484
Cdd:TIGR00599 170 ADYRSEPPNEGLVQCPICQQRMPEKAVERHLDsECL 205
RAD18 COG5432
RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms];
417-484 3.09e-04

RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms];


Pssm-ID: 227719 [Multi-domain]  Cd Length: 391  Bit Score: 43.15  E-value: 3.09e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2172571293 417 KRPRLEDRTALNN-IKEQTQSGGDLED--------SSRPTAISTPRSSGGQRR--LVNCPVCQGVVLESQINEHLDRCL 484
Cdd:COG5432   105 PRPIKEERPCRWEtVIAQDSASGDEEWeddlasnsSPASIAKKTSRDSKKRKRedLVHCPACSNLVPHNQINQHLDSCL 183
SprT COG3091
Predicted Zn-dependent metalloprotease, SprT family [General function prediction only];
90-177 8.38e-04

Predicted Zn-dependent metalloprotease, SprT family [General function prediction only];


Pssm-ID: 442325  Cd Length: 159  Bit Score: 39.87  E-value: 8.38e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2172571293  90 IRLSEPLLKLRPRKDLVETLLHEMIHAYLFVtnndkdREG----HGPEFCKHMHRINqltGANITVYHTFHDEVDEYRRH 165
Cdd:COG3091    51 IRLNPKLLEENGEEFLIEVVPHELAHYHLYQ------EFGrvrpHGKEWRELMEKVG---GLPPRRTHRFDVSSVQGKRY 121

                          90
                  ....*....|..
gi 2172571293 166 WWRCNgpCQHKQ 177
Cdd:COG3091   122 LYRCA--CGQHQ 131
 
Name Accession Description Interval E-value
SprT smart00731
SprT homologues; Predicted to have roles in transcription elongation. Contains a conserved ...
 43-212 3.69e-47

SprT homologues; Predicted to have roles in transcription elongation. Contains a conserved HExxH motif, indicating a metalloprotease function.


Pssm-ID: 214794 [Multi-domain]  Cd Length: 146  Bit Score: 160.18  E-value: 3.69e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2172571293   43 PDLQALFLQFNDRFFWGQLEAVEVKWSVRMTLCAGICTYegrgGMCSIRLSEPLLKLRPRKDLVETLLHEMIHAYLFVTN 122
Cdd:smart00731   1 QELTQRLEDASLRVFGRKLPHPKVVWNKRLRKTGGRCLL----KSAEIRLNPKLLTENGRDRLRETLLHELCHAALYLFG 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2172571293  123 NDKdreGHGPEFCKHMHRINQLTGaniTVYHTFHDEVdeYRRHWWRCNGpCQHkqpYYGYVKRATNRapsahdyWWADHQ 202
Cdd:smart00731  77 RGY---GHGDEWKRWMRQVNGLFP---ERCHTFLIES--VKKYPYRCTG-CGQ---RYLRVRRSNNV-------SRYRCG 137

                          170
                   ....*....|
gi 2172571293  203 KtCGGTYIKI 212
Cdd:smart00731 138 K-CGGKLILI 146
SprT-like pfam10263
SprT-like family; This family represents a domain found in eukaryotes and prokaryotes. The ...
 45-153 2.28e-42

SprT-like family; This family represents a domain found in eukaryotes and prokaryotes. The domain contains a characteriztic motif of the zinc metallopeptidases. This family includes the bacterial SprT protein.


Pssm-ID: 463033  Cd Length: 106  Bit Score: 146.26  E-value: 2.28e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2172571293  45 LQALFLQFNDRFFWGQL-EAVEVKWSVRMTLCAGICTYEGRggmCSIRLSEPLLKLRPRKDLVETLLHEMIHAYLFVTNN 123
Cdd:pfam10263   1 LEELFQQLNDEFFRGFLlPGVSVRWSKRLRTTAGRAHLKRK---NEIRLSEPLLDENPEEFLRETLLHEMIHAYLFVLFG 77

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2172571293 124 dkDREGHGPEFCKHMHRINQL-TGANITVYH 153
Cdd:pfam10263  78 --RRRGHGPEFKAWMERINEAqTGLPITTYH 106
ZnF_Rad18 smart00734
Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative ...
 461-484 1.03e-06

Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative DNA repair. This zinc finger is likely to bind nucleic-acids.


Pssm-ID: 128973 [Multi-domain]  Cd Length: 24  Bit Score: 44.91  E-value: 1.03e-06
                           10        20
                   ....*....|....*....|....
gi 2172571293  461 LVNCPVCQGVVLESQINEHLDRCL 484
Cdd:smart00734   1 LVQCPVCFREVPENLINSHLDSCL 24
rad18 TIGR00599
DNA repair protein rad18; All proteins in this family for which functions are known are ...
 375-484 1.72e-04

DNA repair protein rad18; All proteins in this family for which functions are known are involved in nucleotide excision repair.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273165 [Multi-domain]  Cd Length: 397  Bit Score: 43.84  E-value: 1.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2172571293 375 SRASLRNSSKVTAPASATVTSAAGTSAA-----ISREESGSEDQfLNKRPRLEDRTALNNIKEQTQSGGDLEDSSRPTAI 449
Cdd:TIGR00599  91 LRPSLLEFLRIPKTTPVENPDLAGPENSskielIEESESDGVDA-EDEDLQRSATSSRALAARSTADILQLSSDPSKRND 169

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2172571293 450 STPRSSGGQRRLVNCPVCQGVVLESQINEHLD-RCL 484
Cdd:TIGR00599 170 ADYRSEPPNEGLVQCPICQQRMPEKAVERHLDsECL 205
RAD18 COG5432
RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms];
417-484 3.09e-04

RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms];


Pssm-ID: 227719 [Multi-domain]  Cd Length: 391  Bit Score: 43.15  E-value: 3.09e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2172571293 417 KRPRLEDRTALNN-IKEQTQSGGDLED--------SSRPTAISTPRSSGGQRR--LVNCPVCQGVVLESQINEHLDRCL 484
Cdd:COG5432   105 PRPIKEERPCRWEtVIAQDSASGDEEWeddlasnsSPASIAKKTSRDSKKRKRedLVHCPACSNLVPHNQINQHLDSCL 183
SprT COG3091
Predicted Zn-dependent metalloprotease, SprT family [General function prediction only];
90-177 8.38e-04

Predicted Zn-dependent metalloprotease, SprT family [General function prediction only];


Pssm-ID: 442325  Cd Length: 159  Bit Score: 39.87  E-value: 8.38e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2172571293  90 IRLSEPLLKLRPRKDLVETLLHEMIHAYLFVtnndkdREG----HGPEFCKHMHRINqltGANITVYHTFHDEVDEYRRH 165
Cdd:COG3091    51 IRLNPKLLEENGEEFLIEVVPHELAHYHLYQ------EFGrvrpHGKEWRELMEKVG---GLPPRRTHRFDVSSVQGKRY 121

                          90
                  ....*....|..
gi 2172571293 166 WWRCNgpCQHKQ 177
Cdd:COG3091   122 LYRCA--CGQHQ 131
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH