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Conserved domains on  [gi|2170487616|ref|NP_001385778|]
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bcl-2-like protein 13 [Rattus norvegicus]

Protein Classification

Bcl-2 domain-containing protein( domain architecture ID 10452259)

Bcl-2 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Bcl-2 pfam00452
Apoptosis regulator proteins, Bcl-2 family;
104-200 6.23e-15

Apoptosis regulator proteins, Bcl-2 family;


:

Pssm-ID: 459816  Cd Length: 101  Bit Score: 70.37  E-value: 6.23e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2170487616 104 LAQLGERVSRDLSEPLQKALQMILSQPVT--YEAYRECTVETAvhASG---WNKILVPLVLLQQMLLELARRGQEPL-ST 177
Cdd:pfam00452   1 LRRLGDELERKHPELFQNMLNQLLLTPEDtaYELFREVADELF--SDGvinWGRVVALFAFAGALAVKLVRQGHPELvRR 78

                          90       100
                  ....*....|....*....|...
gi 2170487616 178 LLQFGVMYLEEHGAEFIIQQGGW 200
Cdd:pfam00452  79 LAEWLVDYLEERLADWIIQQGGW 101
 
Name Accession Description Interval E-value
Bcl-2 pfam00452
Apoptosis regulator proteins, Bcl-2 family;
104-200 6.23e-15

Apoptosis regulator proteins, Bcl-2 family;


Pssm-ID: 459816  Cd Length: 101  Bit Score: 70.37  E-value: 6.23e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2170487616 104 LAQLGERVSRDLSEPLQKALQMILSQPVT--YEAYRECTVETAvhASG---WNKILVPLVLLQQMLLELARRGQEPL-ST 177
Cdd:pfam00452   1 LRRLGDELERKHPELFQNMLNQLLLTPEDtaYELFREVADELF--SDGvinWGRVVALFAFAGALAVKLVRQGHPELvRR 78

                          90       100
                  ....*....|....*....|...
gi 2170487616 178 LLQFGVMYLEEHGAEFIIQQGGW 200
Cdd:pfam00452  79 LAEWLVDYLEERLADWIIQQGGW 101
BCL smart00337
BCL (B-Cell lymphoma); contains BH1, BH2 regions; (BH1, BH2, (BH3 (one helix only)) and not ...
 99-200 4.86e-03

BCL (B-Cell lymphoma); contains BH1, BH2 regions; (BH1, BH2, (BH3 (one helix only)) and not BH4(one helix only)). Involved in apoptosis regulation


Pssm-ID: 214626  Cd Length: 100  Bit Score: 36.53  E-value: 4.86e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2170487616   99 SVEDCLAQLGERVSRDLSEPLQkalqmiLSQPVTYEAYREctVETAVHASG---WNKILVPLVLLQQMLLELARRGQEPL 175
Cdd:smart00337   3 RVGDELNKRYERAFSSFSAQLH------VTPGTAIELFGE--VATELFSDGninWGRVVALLSFGGALAVKLVQKEDPDL 74

                           90       100
                   ....*....|....*....|....*.
gi 2170487616  176 -STLLQFGVMYLEEHGAEFIIQQGGW 200
Cdd:smart00337  75 vSRLASWLSEFLRETLRSWIRENGGW 100
bcl-2 TIGR00865
apoptosis regulator; The Bcl-2 (Bcl-2) Family (TC 1.A.21) The Bcl-2 family consists of the ...
 87-206 9.71e-03

apoptosis regulator; The Bcl-2 (Bcl-2) Family (TC 1.A.21) The Bcl-2 family consists of the apoptosis regulator, Bcl-X, and its homologues. Bcl-X is a dominant regulator of programmed cell death in mammalian cells. The long form (Bcl-X(L)) displays cell death repressor activity, but the short isoform (Bcl-X(S)) and the b-isoform (Bcl-Xb) promote cell death. Bcl-X(L), Bcl-X(S) and Bcl-Xb are three isoforms derived by alternative RNA splicing. Bcl-X(S) forms heterodimers with Bcl-2. Homologues of Bcl-X include the Bax (rat; 192 aas; spQ63690) and Bak (mouse; 208 aas; spO08734) proteins which also influence apoptosis. Using isolated mitochondria, recombinant Bax and Bak have been shown to induce Dy loss, swelling and cytochrome c release. All of these changes are dependent on Ca2+ and are prevented by cyclosporin A and bongkrekic acid, both of which are known to close permeability transition pores (megachannels). Coimmimoprecipitation studies revealed that Bax and Bak interact with VDAC to form permeability transition pores. Thus, even though they can form channels in artificial membranes at acidic pH, proapoptotic Bcl-2 family proteins (including Bax and Bak) probably induce the mitochondrial permeability transition and cytochrome c release by interacting with permeability transition pores, the most important component for pore fomation of which is VDAC. [Regulatory functions, Other]


Pssm-ID: 273308 [Multi-domain]  Cd Length: 213  Bit Score: 37.49  E-value: 9.71e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2170487616  87 TSPVFSPANPESSVEDCLAQLGERVSRDLSEPLQKALQMILSQ----PVT-YEAYRECTVETAVHASGWNKILVPLVLLQ 161
Cdd:TIGR00865  50 TGETPSEGPPQDPPPSAVHQALRRAGDEFERRYRRAFSDMTSQlhitPFTaRQSFFQVAAELFRDGVNWGRIVAFFSFGG 129

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 2170487616 162 QMLLELARRGQEPL-STLLQFGVMYLEEHGAEFIIQQGGWGTVFSL 206
Cdd:TIGR00865 130 ALCVESVNKEMSELvSRIAGWMTEYLNEHLHPWIQENGGWDGFVEL 175
 
Name Accession Description Interval E-value
Bcl-2 pfam00452
Apoptosis regulator proteins, Bcl-2 family;
104-200 6.23e-15

Apoptosis regulator proteins, Bcl-2 family;


Pssm-ID: 459816  Cd Length: 101  Bit Score: 70.37  E-value: 6.23e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2170487616 104 LAQLGERVSRDLSEPLQKALQMILSQPVT--YEAYRECTVETAvhASG---WNKILVPLVLLQQMLLELARRGQEPL-ST 177
Cdd:pfam00452   1 LRRLGDELERKHPELFQNMLNQLLLTPEDtaYELFREVADELF--SDGvinWGRVVALFAFAGALAVKLVRQGHPELvRR 78

                          90       100
                  ....*....|....*....|...
gi 2170487616 178 LLQFGVMYLEEHGAEFIIQQGGW 200
Cdd:pfam00452  79 LAEWLVDYLEERLADWIIQQGGW 101
BCL smart00337
BCL (B-Cell lymphoma); contains BH1, BH2 regions; (BH1, BH2, (BH3 (one helix only)) and not ...
 99-200 4.86e-03

BCL (B-Cell lymphoma); contains BH1, BH2 regions; (BH1, BH2, (BH3 (one helix only)) and not BH4(one helix only)). Involved in apoptosis regulation


Pssm-ID: 214626  Cd Length: 100  Bit Score: 36.53  E-value: 4.86e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2170487616   99 SVEDCLAQLGERVSRDLSEPLQkalqmiLSQPVTYEAYREctVETAVHASG---WNKILVPLVLLQQMLLELARRGQEPL 175
Cdd:smart00337   3 RVGDELNKRYERAFSSFSAQLH------VTPGTAIELFGE--VATELFSDGninWGRVVALLSFGGALAVKLVQKEDPDL 74

                           90       100
                   ....*....|....*....|....*.
gi 2170487616  176 -STLLQFGVMYLEEHGAEFIIQQGGW 200
Cdd:smart00337  75 vSRLASWLSEFLRETLRSWIRENGGW 100
bcl-2 TIGR00865
apoptosis regulator; The Bcl-2 (Bcl-2) Family (TC 1.A.21) The Bcl-2 family consists of the ...
 87-206 9.71e-03

apoptosis regulator; The Bcl-2 (Bcl-2) Family (TC 1.A.21) The Bcl-2 family consists of the apoptosis regulator, Bcl-X, and its homologues. Bcl-X is a dominant regulator of programmed cell death in mammalian cells. The long form (Bcl-X(L)) displays cell death repressor activity, but the short isoform (Bcl-X(S)) and the b-isoform (Bcl-Xb) promote cell death. Bcl-X(L), Bcl-X(S) and Bcl-Xb are three isoforms derived by alternative RNA splicing. Bcl-X(S) forms heterodimers with Bcl-2. Homologues of Bcl-X include the Bax (rat; 192 aas; spQ63690) and Bak (mouse; 208 aas; spO08734) proteins which also influence apoptosis. Using isolated mitochondria, recombinant Bax and Bak have been shown to induce Dy loss, swelling and cytochrome c release. All of these changes are dependent on Ca2+ and are prevented by cyclosporin A and bongkrekic acid, both of which are known to close permeability transition pores (megachannels). Coimmimoprecipitation studies revealed that Bax and Bak interact with VDAC to form permeability transition pores. Thus, even though they can form channels in artificial membranes at acidic pH, proapoptotic Bcl-2 family proteins (including Bax and Bak) probably induce the mitochondrial permeability transition and cytochrome c release by interacting with permeability transition pores, the most important component for pore fomation of which is VDAC. [Regulatory functions, Other]


Pssm-ID: 273308 [Multi-domain]  Cd Length: 213  Bit Score: 37.49  E-value: 9.71e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2170487616  87 TSPVFSPANPESSVEDCLAQLGERVSRDLSEPLQKALQMILSQ----PVT-YEAYRECTVETAVHASGWNKILVPLVLLQ 161
Cdd:TIGR00865  50 TGETPSEGPPQDPPPSAVHQALRRAGDEFERRYRRAFSDMTSQlhitPFTaRQSFFQVAAELFRDGVNWGRIVAFFSFGG 129

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 2170487616 162 QMLLELARRGQEPL-STLLQFGVMYLEEHGAEFIIQQGGWGTVFSL 206
Cdd:TIGR00865 130 ALCVESVNKEMSELvSRIAGWMTEYLNEHLHPWIQENGGWDGFVEL 175
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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