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Conserved domains on  [gi|2026128528|ref|NP_001381276|]
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leucine-rich repeat-containing protein 23 [Rattus norvegicus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1903219)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 80-306 7.44e-18

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd21340:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 220  Bit Score: 80.99  E-value: 7.44e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026128528  80 DRDLTDISLLRSYIHLRYVDISENHITDMSPLNSLTHLLWLkadgnqlrsarlnelpYLQiasfsynqitdtegiihprl 159
Cdd:cd21340    11 DKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHL----------------YLQ-------------------- 54

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026128528 160 gsldlkGNRIhqvtgldpERLTNLHtlelranqlettigiNLPKLKNLYLAQNLLKKVEGLENLSNLTTLHL-------- 231
Cdd:cd21340    55 ------NNQI--------EKIENLE---------------NLVNLKKLYLGGNRISVVEGLENLTNLEELHIenqrlppg 105

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026128528 232 ----------------------RDNQIETLDGFSKeMKSLQYLNLRSNMISDLGELAK-LRDLPKLRALVLLDNPCADET 288
Cdd:cd21340   106 ekltfdprslaalsnslrvlniSGNNIDSLEPLAP-LRNLEQLDASNNQISDLEELLDlLSSWPSLRELDLTGNPVCKKP 184

                         250
                  ....*....|....*...
gi 2026128528 289 DYRQEALVQMAHLERLDK 306
Cdd:cd21340   185 KYRDKIILASKSLEVLDG 202
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 80-306 7.44e-18

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 80.99  E-value: 7.44e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026128528  80 DRDLTDISLLRSYIHLRYVDISENHITDMSPLNSLTHLLWLkadgnqlrsarlnelpYLQiasfsynqitdtegiihprl 159
Cdd:cd21340    11 DKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHL----------------YLQ-------------------- 54

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026128528 160 gsldlkGNRIhqvtgldpERLTNLHtlelranqlettigiNLPKLKNLYLAQNLLKKVEGLENLSNLTTLHL-------- 231
Cdd:cd21340    55 ------NNQI--------EKIENLE---------------NLVNLKKLYLGGNRISVVEGLENLTNLEELHIenqrlppg 105

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026128528 232 ----------------------RDNQIETLDGFSKeMKSLQYLNLRSNMISDLGELAK-LRDLPKLRALVLLDNPCADET 288
Cdd:cd21340   106 ekltfdprslaalsnslrvlniSGNNIDSLEPLAP-LRNLEQLDASNNQISDLEELLDlLSSWPSLRELDLTGNPVCKKP 184

                         250
                  ....*....|....*...
gi 2026128528 289 DYRQEALVQMAHLERLDK 306
Cdd:cd21340   185 KYRDKIILASKSLEVLDG 202
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
75-282 9.77e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 80.75  E-value: 9.77e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026128528  75 KLEVKDRDLTDI-SLLRSYIHLRYVDISENHITDM-SPLNSLTHLLWLKADGNQLRS--ARLNELPYLQIASFSYNQITD 150
Cdd:COG4886   117 SLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLpEPLGNLTNLKSLDLSNNQLTDlpEELGNLTNLKELDLSNNQITD 196

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026128528 151 TEGIIH--PRLGSLDLKGNRIhqvTGLDPE--RLTNLHTLELRANQLETTIGI-NLPKLKNLYLAQNLLKKVEGLENLSN 225
Cdd:COG4886   197 LPEPLGnlTNLEELDLSGNQL---TDLPEPlaNLTNLETLDLSNNQLTDLPELgNLTNLEELDLSNNQLTDLPPLANLTN 273

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2026128528 226 LTTLHLRDNQIETLDGfsKEMKSLQYLNLRSNMISDLGELAKLRDLPKLRALVLLDN 282
Cdd:COG4886   274 LKTLDLSNNQLTDLKL--KELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLL 328
LRR_9 pfam14580
Leucine-rich repeat;
186-305 1.11e-09

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 56.70  E-value: 1.11e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026128528 186 LELRANQLE--TTIGINLPKLKNLYLAQNLLKKVEGLENLSNLTTLHLRDNQI-ETLDGFSKEMKSLQYLNLRSNMISDL 262
Cdd:pfam14580  24 LDLRGYKIPiiENLGATLDQFDTIDFSDNEIRKLDGFPLLRRLKTLLLNNNRIcRIGEGLGEALPNLTELILTNNNLQEL 103

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 2026128528 263 GELAKLRDLPKLRALVLLDNPCADETDYRQEALVQMAHLERLD 305
Cdd:pfam14580 104 GDLDPLASLKKLTFLSLLRNPVTNKPHYRLYVIYKVPQLRLLD 146
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 85-304 1.38e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 56.39  E-value: 1.38e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026128528  85 DISLLRSyiHLRYVDISENHITDMSPLNSLTHLLWLKADGNQLrSARLnelpYLQIASFSynqitdtegiihpRLGSLDL 164
Cdd:PLN00113  112 DIFTTSS--SLRYLNLSNNNFTGSIPRGSIPNLETLDLSNNML-SGEI----PNDIGSFS-------------SLKVLDL 171

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026128528 165 KGNRIhqvTGLDPERLTNLHTLE---LRANQLETTIGINLPKLKNL---YLAQNLL-----KKVEGLENLSNLTTLHlrD 233
Cdd:PLN00113  172 GGNVL---VGKIPNSLTNLTSLEfltLASNQLVGQIPRELGQMKSLkwiYLGYNNLsgeipYEIGGLTSLNHLDLVY--N 246

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2026128528 234 NQIETLDGFSKEMKSLQYLNLRSNMISdlGELAK-LRDLPKLRALVLLDNPCADETdyrQEALVQMAHLERL 304
Cdd:PLN00113  247 NLTGPIPSSLGNLKNLQYLFLYQNKLS--GPIPPsIFSLQKLISLDLSDNSLSGEI---PELVIQLQNLEIL 313
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 80-306 7.44e-18

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 80.99  E-value: 7.44e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026128528  80 DRDLTDISLLRSYIHLRYVDISENHITDMSPLNSLTHLLWLkadgnqlrsarlnelpYLQiasfsynqitdtegiihprl 159
Cdd:cd21340    11 DKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHL----------------YLQ-------------------- 54

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026128528 160 gsldlkGNRIhqvtgldpERLTNLHtlelranqlettigiNLPKLKNLYLAQNLLKKVEGLENLSNLTTLHL-------- 231
Cdd:cd21340    55 ------NNQI--------EKIENLE---------------NLVNLKKLYLGGNRISVVEGLENLTNLEELHIenqrlppg 105

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026128528 232 ----------------------RDNQIETLDGFSKeMKSLQYLNLRSNMISDLGELAK-LRDLPKLRALVLLDNPCADET 288
Cdd:cd21340   106 ekltfdprslaalsnslrvlniSGNNIDSLEPLAP-LRNLEQLDASNNQISDLEELLDlLSSWPSLRELDLTGNPVCKKP 184

                         250
                  ....*....|....*...
gi 2026128528 289 DYRQEALVQMAHLERLDK 306
Cdd:cd21340   185 KYRDKIILASKSLEVLDG 202
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
75-282 9.77e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 80.75  E-value: 9.77e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026128528  75 KLEVKDRDLTDI-SLLRSYIHLRYVDISENHITDM-SPLNSLTHLLWLKADGNQLRS--ARLNELPYLQIASFSYNQITD 150
Cdd:COG4886   117 SLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLpEPLGNLTNLKSLDLSNNQLTDlpEELGNLTNLKELDLSNNQITD 196

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026128528 151 TEGIIH--PRLGSLDLKGNRIhqvTGLDPE--RLTNLHTLELRANQLETTIGI-NLPKLKNLYLAQNLLKKVEGLENLSN 225
Cdd:COG4886   197 LPEPLGnlTNLEELDLSGNQL---TDLPEPlaNLTNLETLDLSNNQLTDLPELgNLTNLEELDLSNNQLTDLPPLANLTN 273

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2026128528 226 LTTLHLRDNQIETLDGfsKEMKSLQYLNLRSNMISDLGELAKLRDLPKLRALVLLDN 282
Cdd:COG4886   274 LKTLDLSNNQLTDLKL--KELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLL 328
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
100-282 4.63e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.44  E-value: 4.63e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026128528 100 ISENHITDMSPLNSLTHLLWLKADGNQLrsarLNELPYLQIASFSYNQITDTEGIIH--PRLGSLDLKGNRIhqvTGLDP 177
Cdd:COG4886    81 LLSLLLLGLTDLGDLTNLTELDLSGNEE----LSNLTNLESLDLSGNQLTDLPEELAnlTNLKELDLSNNQL---TDLPE 153

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026128528 178 E--RLTNLHTLELRANQLET---TIGiNLPKLKNLYLAQNLLKKV-EGLENLSNLTTLHLRDNQIETLDGFSKEMKSLQY 251
Cdd:COG4886   154 PlgNLTNLKSLDLSNNQLTDlpeELG-NLTNLKELDLSNNQITDLpEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLET 232

                         170       180       190
                  ....*....|....*....|....*....|.
gi 2026128528 252 LNLRSNMISDLGELAKlrdLPKLRALVLLDN 282
Cdd:COG4886   233 LDLSNNQLTDLPELGN---LTNLEELDLSNN 260
LRR_9 pfam14580
Leucine-rich repeat;
186-305 1.11e-09

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 56.70  E-value: 1.11e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026128528 186 LELRANQLE--TTIGINLPKLKNLYLAQNLLKKVEGLENLSNLTTLHLRDNQI-ETLDGFSKEMKSLQYLNLRSNMISDL 262
Cdd:pfam14580  24 LDLRGYKIPiiENLGATLDQFDTIDFSDNEIRKLDGFPLLRRLKTLLLNNNRIcRIGEGLGEALPNLTELILTNNNLQEL 103

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 2026128528 263 GELAKLRDLPKLRALVLLDNPCADETDYRQEALVQMAHLERLD 305
Cdd:pfam14580 104 GDLDPLASLKKLTFLSLLRNPVTNKPHYRLYVIYKVPQLRLLD 146
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
75-241 2.94e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 58.02  E-value: 2.94e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026128528  75 KLEVKDRDLTDISL-LRSYIHLRYVDISENHITDMS-PLNSLTHLLWLKADGNQLRS--ARLNELPYLQIASFSYNQITD 150
Cdd:COG4886   163 SLDLSNNQLTDLPEeLGNLTNLKELDLSNNQITDLPePLGNLTNLEELDLSGNQLTDlpEPLANLTNLETLDLSNNQLTD 242

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026128528 151 TEGIIH-PRLGSLDLKGNRIhqvTGLDPE-RLTNLHTLELRANQLETTIGINLPKLKNLYLAQNLLKKVEGLENLSNLTT 228
Cdd:COG4886   243 LPELGNlTNLEELDLSNNQL---TDLPPLaNLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLL 319

                         170
                  ....*....|...
gi 2026128528 229 LHLRDNQIETLDG 241
Cdd:COG4886   320 LTTLLLLLLLLKG 332
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 179-271 3.67e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 56.33  E-value: 3.67e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026128528 179 RLTNLHtleLRANQLETTIGINL-PKLKNLYLAQNLLKKVEGLENLSNLTTLHLRDNQIETLDGFSKeMKSLQYLNLRSN 257
Cdd:cd21340     3 RITHLY---LNDKNITKIDNLSLcKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLEN-LVNLKKLYLGGN 78

                          90
                  ....*....|....
gi 2026128528 258 MISDLGELAKLRDL 271
Cdd:cd21340    79 RISVVEGLENLTNL 92
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 94-308 5.72e-09

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 57.11  E-value: 5.72e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026128528  94 HLRYVDISENHITDMS--------PLNSLTHLLWLKADGNQLRSAR-----LNELPYLQIASFSYNQITDtEGII----- 155
Cdd:COG5238   181 SVETVYLGCNQIGDEGieelaealTQNTTVTTLWLKRNPIGDEGAEilaeaLKGNKSLTTLDLSNNQIGD-EGVIalaea 259

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026128528 156 --HPR-LGSLDLKGNRIhQVTGLDP-----ERLTNLHTLELRANQLETTIGINLPK-------LKNLYLAQNLLKKV--- 217
Cdd:COG5238   260 lkNNTtVETLYLSGNQI-GAEGAIAlakalQGNTTLTSLDLSVNRIGDEGAIALAEglqgnktLHTLNLAYNGIGAQgai 338

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026128528 218 ---EGLENLSNLTTLHLRDNQI-----ETLDGFSKEMKSLQYLNLRSNMISDLG--ELAKLRDLPKLRALVLLDNPCADE 287
Cdd:COG5238   339 alaKALQENTTLHSLDLSDNQIgdegaIALAKYLEGNTTLRELNLGKNNIGKQGaeALIDALQTNRLHTLILDGNLIGAE 418

                         250       260
                  ....*....|....*....|.
gi 2026128528 288 TDYRQEALvqmahLERLDKEY 308
Cdd:COG5238   419 AQQRLEQL-----LERIKSVY 434
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 85-304 1.38e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 56.39  E-value: 1.38e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026128528  85 DISLLRSyiHLRYVDISENHITDMSPLNSLTHLLWLKADGNQLrSARLnelpYLQIASFSynqitdtegiihpRLGSLDL 164
Cdd:PLN00113  112 DIFTTSS--SLRYLNLSNNNFTGSIPRGSIPNLETLDLSNNML-SGEI----PNDIGSFS-------------SLKVLDL 171

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026128528 165 KGNRIhqvTGLDPERLTNLHTLE---LRANQLETTIGINLPKLKNL---YLAQNLL-----KKVEGLENLSNLTTLHlrD 233
Cdd:PLN00113  172 GGNVL---VGKIPNSLTNLTSLEfltLASNQLVGQIPRELGQMKSLkwiYLGYNNLsgeipYEIGGLTSLNHLDLVY--N 246

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2026128528 234 NQIETLDGFSKEMKSLQYLNLRSNMISdlGELAK-LRDLPKLRALVLLDNPCADETdyrQEALVQMAHLERL 304
Cdd:PLN00113  247 NLTGPIPSSLGNLKNLQYLFLYQNKLS--GPIPPsIFSLQKLISLDLSDNSLSGEI---PELVIQLQNLEIL 313
LRR_8 pfam13855
Leucine rich repeat;
202-259 1.10e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.21  E-value: 1.10e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2026128528 202 PKLKNLYLAQNLLKKVEG--LENLSNLTTLHLRDNQIETLDG--FSKeMKSLQYLNLRSNMI 259
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDgaFKGLSNLKVLDLSNNLLTTLSPgaFSG-LPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
224-283 1.53e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.82  E-value: 1.53e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2026128528 224 SNLTTLHLRDNQIETL-DGFSKEMKSLQYLNLRSNMISDLGELAkLRDLPKLRALVLLDNP 283
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLSPGA-FSGLPSLRYLDLSGNR 60
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 202-244 2.49e-05

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 41.08  E-value: 2.49e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 2026128528 202 PKLKNLYLAQNLLKKVEGLENLSNLTTLHLRDN-QIETLDGFSK 244
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSGNnKITDLSDLAN 44
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 225-267 1.02e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 39.15  E-value: 1.02e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 2026128528 225 NLTTLHLRDNQIETLDGFSKeMKSLQYLNLRSN-MISDLGELAK 267
Cdd:pfam12799   2 NLEVLDLSNNQITDIPPLAK-LPNLETLDLSGNnKITDLSDLAN 44
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 95-165 1.85e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 42.08  E-value: 1.85e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026128528  95 LRYVDISENHITDMSPLNSLTHLLWLKADGNQLRSAR-----LNELPYLQIASFSYNQITDT----EGII--HPRLGSLD 163
Cdd:cd21340   122 LRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEelldlLSSWPSLRELDLTGNPVCKKpkyrDKIIlaSKSLEVLD 201


                  ..
gi 2026128528 164 LK 165
Cdd:cd21340   202 GK 203
LRR_8 pfam13855
Leucine rich repeat;
181-236 4.18e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.89  E-value: 4.18e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2026128528 181 TNLHTLELRANQL---ETTIGINLPKLKNLYLAQNLLKKVEG--LENLSNLTTLHLRDNQI 236
Cdd:pfam13855   1 PNLRSLDLSNNRLtslDDGAFKGLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
83-239 5.15e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 41.46  E-value: 5.15e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026128528  83 LTDISLLRSYIHLRYVDISENHITDMSPLNSLTHLLWLKADGNQLRSARLNELP-YLQIASFSYNQITDTEGIIHPRLGS 161
Cdd:COG4886   240 LTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELElLLGLNSLLLLLLLLNLLELLILLLL 319

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2026128528 162 LDLKGNRIHQVTGLDPERLTNLHTLELRANQLETTIGINLPKLKNLYLAQNLLKKVEGLENLSNLTTLHLRDNQIETL 239
Cdd:COG4886   320 LTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTT 397
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 179-287 5.71e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 41.19  E-value: 5.71e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026128528 179 RLTNLHTLELRANQLETTIGINL--------PKLKNLYLAQNLLKkVEGLENLSN-------LTTLHLRDNQIeTLDGFS 243
Cdd:cd00116   106 RSSSLQELKLNNNGLGDRGLRLLakglkdlpPALEKLVLGRNRLE-GASCEALAKalranrdLKELNLANNGI-GDAGIR 183

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2026128528 244 ------KEMKSLQYLNLRSNMISDLGELA---KLRDLPKLRALVLLDNPCADE 287
Cdd:cd00116   184 alaeglKANCNLEVLDLNNNGLTDEGASAlaeTLASLKSLEVLNLGDNNLTDA 236
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
180-305 6.93e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 37.99  E-value: 6.93e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026128528 180 LTNLHTLELRANQLETTIGINLPKLKNLYLAQNLLKKVEGLENLSNLTTLH-----------------LRDNQIETLDGF 242
Cdd:COG4886    52 LLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDlsgneelsnltnlesldLSGNQLTDLPEE 131

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2026128528 243 SKEMKSLQYLNLRSNMISDLGElaKLRDLPKLRALVLLDNPCADETdyrqEALVQMAHLERLD 305
Cdd:COG4886   132 LANLTNLKELDLSNNQLTDLPE--PLGNLTNLKSLDLSNNQLTDLP----EELGNLTNLKELD 188
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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